MCID: MNN013
MIFTS: 71

Meningitis

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Meningitis

Summaries for Meningitis

NINDS : 50 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone can get encephalitis or meningitis.Inflammation from encephalitis and meningitis produce a wide range of symptoms.  Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Symptoms of meningitis, which may appear suddenly, often include high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, and vomiting. Changes in behavior such as confusion, sleepiness, and difficulty waking up may also occur. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head). Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately.

MalaCards based summary : Meningitis is related to viral meningitis and aseptic meningitis, and has symptoms including sleeplessness, vertigo/dizziness and hyperexplexia. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

MedlinePlus : 40 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

CDC : 3 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Wikipedia : 72 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1044)
# Related Disease Score Top Affiliating Genes
1 viral meningitis 34.2 ADA CRP CXCL8 IL6
2 aseptic meningitis 34.2 CXCL8 IL10 IL1B NLRP3 TNF
3 meningococcal meningitis 34.0 CFP MBL2 TLR9
4 chronic meningitis 34.0 CRP MMP9 NLRP3
5 tuberculous meningitis 33.5 ADA CXCL8 LYZ MMP9 TLR2 TNF
6 streptococcal meningitis 32.8 ADA CD40LG CFP CRP MBL2 TNF
7 listeriosis 32.6 IL10 IL6 MBL2 TNF
8 bacterial meningitis 32.4 ALB CFP CRP CXCL8 IL10 IL1B
9 meningococcemia 32.3 CFP IL1B MBL2
10 extrapulmonary tuberculosis 32.0 ADA IL10 IL1B TLR2
11 mannose-binding lectin deficiency 32.0 CFP IL6 MBL2
12 meningoencephalitis 31.9 ALB CD40LG IL6 TLR9
13 neisseria meningitidis infection 31.7 CFP LACTB MBL2 TLR2
14 tuberculous peritonitis 31.6 ADA ALB CRP TNF
15 cerebral palsy 31.5 IL1B IL6 MBL2 TNF
16 leptospirosis 30.9 CD40LG CRP CXCL8 IL10 IL1B IL6
17 haemophilus influenzae 30.9 CXCL8 IL1B TLR2 TNF
18 bacteremia 2 30.6 CRP LACTB MBL2
19 suppurative otitis media 30.3 CRP IL1B TLR2
20 mycobacterium fortuitum 30.3 CXCL8 LACTB
21 adult-onset still's disease 30.3 CRP IL1B IL6 TNF
22 lymphadenitis 30.3 CXCL8 IL10 IL1B TNF
23 osteomyelitis 30.2 CXCL8 IL10 IL1B IL6 TNF
24 brain edema 30.2 ALB IL1B IL6 MMP9
25 rubella 30.2 CD40LG IL10 TNF
26 pharyngitis 30.1 CRP CXCL8 IL1B
27 cellulitis 30.1 CRP LACTB TNF
28 hematopoietic stem cell transplantation 30.1 IL10 IL6 TNF
29 transverse myelitis 30.1 CXCL8 IL10 IL6 MMP9 TNF
30 behcet syndrome 30.1 ADA CD40LG CRP CXCL8 IL10 IL1B
31 arthritis 30.1 CXCL8 IL10 IL1B IL6 MMP9 TNF
32 viral encephalitis 30.1 CXCL8 IL10 IL1B IL6 TNF
33 purpura 30.0 CD40LG CRP TNF
34 vaginitis 30.0 CXCL8 IL1B IL6
35 infective endocarditis 30.0 CRP IL6 TLR2 TNF
36 burns 29.9 ALB IL1B TNF
37 familial mediterranean fever 29.9 CRP IL1B NLRP3 TNF
38 pericardial effusion 29.9 ADA CRP IL6
39 mixed connective tissue disease 29.9 CD40LG IL10 IL6 TNF
40 cystitis 29.9 CRP CXCL8 IL6 TNF
41 mycobacterium abscessus 29.9 CXCL8 NLRP3 TLR2 TNF
42 prostatitis 29.8 CXCL8 IL10 IL1B IL6 TNF
43 pertussis 29.8 IL10 IL1B IL6 TNF
44 acute pancreatitis 29.8 CRP CXCL8 IL10 IL6
45 genital herpes 29.8 IL10 TLR2 TLR9
46 mycobacterium chelonae 29.8 CXCL8 TLR2
47 diverticulitis 29.8 CRP MMP9 TNF
48 fasciitis 29.8 CXCL8 IL6 TNF
49 pericarditis 29.8 ADA CRP IL1B IL6 IRAK4 TNF
50 crohn's disease 29.7 CRP IL10 IL1B IL6 TLR9 TNF

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:


sleeplessness, vertigo/dizziness, hyperexplexia, chronic pain, tremor, syncope, seizures, sciatica, pruritus, pain, meningism, hemiplegia, headache, fever, back pain

MGI Mouse Phenotypes related to Meningitis:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ADA ALB CD40LG CFP CRP IL10
2 immune system MP:0005387 10.28 ADA CD40LG CFP CRP IL10 IL1B
3 cellular MP:0005384 10.27 LYZ MMP9 NLRP3 TLR2 TLR9 TNF
4 hematopoietic system MP:0005397 10.27 IRAK4 LYZ MBL2 MMP9 NLRP3 TLR2
5 cardiovascular system MP:0005385 10.25 ADA CD40LG CFP CRP IL10 IL1B
6 digestive/alimentary MP:0005381 10.18 IL6 LYZ MMP9 NLRP3 TLR2 TLR9
7 mortality/aging MP:0010768 10.07 ADA ALB CD40LG CFP IL10 IL1B
8 integument MP:0010771 10.02 CD40LG IL10 IL1B IL6 LYZ MMP9
9 liver/biliary system MP:0005370 9.92 TLR2 TNF ADA ALB IL10 IL6
10 neoplasm MP:0002006 9.76 ALB IL10 IL1B IL6 LYZ MMP9
11 renal/urinary system MP:0005367 9.65 ADA ALB CD40LG IL6 LYZ MBL2
12 skeleton MP:0005390 9.36 MMP9 NLRP3 TLR2 TNF ADA CD40LG

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 354)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 1 147-94-4 6253
3
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
4
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3 154598-52-4 64139
5
Zidovudine Approved Phase 4 30516-87-1 35370
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
7
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 5280965 14956
8
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 86386-73-4 3365
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
11
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
12
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
13
Azathioprine Approved Phase 4 446-86-6 2265
14
Ceftriaxone Approved Phase 4,Phase 3,Phase 1 73384-59-5 5479530 5361919
15
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
16
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
17
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
18
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 5742673 456256
19
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
20
Cosyntropin Approved Phase 4 16960-16-0 16129617
21
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
23
Lactitol Investigational Phase 4,Phase 2,Phase 3 585-86-4 3871
24
BCG vaccine Investigational Phase 4,Phase 2
25 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
26 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3
27 Sodium Channel Blockers Phase 4
28 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Gentamicins Phase 4,Phase 2,Phase 3
30 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
31 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
32 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
33 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
36 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
38 Diuretics, Potassium Sparing Phase 4
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Antibodies, Monoclonal Phase 4,Phase 1,Phase 2
41 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Anticonvulsants Phase 4
43 Anti-HIV Agents Phase 4,Phase 2,Phase 3
44 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
47 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
49 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 453)

# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
3 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
4 Determination of Gentamicin Dosing in Neonatal Patients Unknown status NCT00198601 Phase 4 Gentamicin in Uniject Pre-filled syringe
5 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
6 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
7 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
8 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
9 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
10 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4 Ceftriaxone treatment
11 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
12 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
13 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
14 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Completed NCT01119482 Phase 4
15 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
16 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
17 Descriptive, Post-marketing, Surveillance Safety Study of Menactra Vaccine Completed NCT00254995 Phase 4
18 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
19 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
20 Effect of Meningococcal Conjugate Vaccine on Meningococcal Carriage Completed NCT00119080 Phase 4
21 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
22 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
23 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
24 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
25 Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
26 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
27 A Phase IV Study to Evaluate the Immunogenicity and Safety in UK Laboratory Workers of Menitorix Completed NCT00503165 Phase 4
28 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
29 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
30 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
31 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
32 Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients Completed NCT01781871 Phase 4
33 Safety and Local Tolerability of Prevenar in Indian Children Completed NCT00488800 Phase 4
34 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
35 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
36 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
37 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Completed NCT02145624 Phase 4 Repevax;Boostrix-IPV
38 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
39 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
40 Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time Completed NCT00581035 Phase 4
41 Evaluation of Meningococcal C Vaccine Programmes in Canadian Children Completed NCT00936962 Phase 4
42 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
43 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
44 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
45 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4
46 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
47 Investigating the Immune Response to 4CMenB in Infants Active, not recruiting NCT02080559 Phase 4
48 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Active, not recruiting NCT02864927 Phase 4
49 A Study of the Interaction Between BCG And MenC Immunisation: BAM Active, not recruiting NCT02002156 Phase 4
50 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Genetic Tests for Meningitis

Genetic tests related to Meningitis:

# Genetic test Affiliating Genes
1 Meningitis 28

Anatomical Context for Meningitis

MalaCards organs/tissues related to Meningitis:

38
Brain, Spinal Cord, Testes, Bone, B Cells, T Cells, Pituitary

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 5983)
# Title Authors Year
1
Streptococcus salivarius meningitis: a spontaneous case in a 74-year-old man. ( 29423872 )
2018
2
Osmotic therapies added to antibiotics for acute bacterial meningitis. ( 29405037 )
2018
3
Diffuse Leptomeningeal Glioneural Tumour Simulating Tuberculous Meningitis in a 13-Year-Old Girl. ( 29301133 )
2018
4
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. ( 29366968 )
2018
5
Diagnosing and Understanding Angiostrongyliasis, A Zoonotic Cause of Meningitis. ( 29411969 )
2018
6
Drug-induced aseptic meningitis: A possible T-cell-mediated hypersensitivity. ( 29310902 )
2018
7
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
8
Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland. ( 29384979 )
2018
9
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia. ( 29444749 )
2018
10
Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India. ( 29332649 )
2018
11
Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis. ( 29379704 )
2018
12
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
13
Unexpected Ventriculitis Complication of Neonatal Meningitis Caused by Streptococcus gallolyticus Subsp. pasteurianus: a Case Report. ( 29279439 )
2018
14
Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana. ( 29371015 )
2018
15
Elevations of novel cytokines in bacterial meningitis in infants. ( 29394248 )
2018
16
The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report. ( 29429850 )
2018
17
Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited Setting. ( 29390160 )
2018
18
Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study. ( 29427117 )
2018
19
Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted time-series analysis. ( 29351491 )
2018
20
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
21
Management of suspected paediatric meningitis: a multicentre prospective cohort study. ( 29436406 )
2018
22
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
23
Community-Acquired Meningitis in HIV-Infected Patients in the United States. ( 29432047 )
2018
24
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
25
Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29188363 )
2018
26
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
27
Rapid Reversal of Complete Binocular Blindness With High-Dose Corticosteroids and Lumbar Drain in a Solid Organ Transplant Recipient With Cryptococcal Meningitis and Immune Reconstitution Syndrome: First Case Study and Literature Review. ( 29423423 )
2018
28
Adult Patients with Pneumococcal Meningitis at a Neurosurgical Neurologic Center: Different Predisposing Conditions? ( 29170119 )
2018
29
Current status of cerebrospinal meningitis and impact of the 2015 meningococcal C vaccination in Kebbi, Northwest Nigeria. ( 29426659 )
2018
30
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
31
The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: A clinical comparison with Ps. aeruginosa meningitis. ( 29310816 )
2018
32
Correction to: Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29322336 )
2018
33
Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis. ( 29402222 )
2018
34
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
35
Could omics unlock the secret of surviving tuberculous meningitis? ( 29398390 )
2018
36
Analysis of enterovirus types in patients with symptoms of aseptic meningitis in 2014 in Shandong, China. ( 29407377 )
2018
37
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
38
Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. ( 29297432 )
2018
39
Anaerobic bacterial meningitis in adults. ( 29396061 )
2018
40
Meningeal marginal zone B-cell lymphoma: The meningioma trap. ( 29331570 )
2018
41
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. ( 29394269 )
2018
42
Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. ( 29352446 )
2018
43
Acral-accentuated exanthem in an infant with parechovirus meningitis. ( 29205494 )
2018
44
Evaluation of a Commercial Multiplex Molecular Panel For the Diagnosis of Infectious Meningitis and Encephalitis. ( 29436421 )
2018
45
Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Meditated Isothermal Amplification (TEC-LAMP) Assay for the Detection of Bacterial Meningitis Pathogens. ( 29425124 )
2018
46
Ectopic Prolactinoma Presenting as Bacterial Meningitis: A Diagnostic Conundrum. ( 29378345 )
2018
47
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
48
Novel and preclinical treatment strategies in pneumococcal meningitis. ( 29095719 )
2018
49
Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. ( 29374632 )
2018
50
Focal Encephalitis, Meningitis and Acute Respiratory Distress Syndrome Associated with Influenza A Infection. ( 29402867 )
2018

Variations for Meningitis

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL4 CD40LG CFP CRP CXCL1 CXCL8
2
Show member pathways
13.51 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
3
Show member pathways
13.47 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
4
Show member pathways
13.37 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
5
Show member pathways
13.09 CXCL1 CXCL8 IL1B IL6 IRAK4 NLRP3
6
Show member pathways
12.93 CD40LG CXCL8 IL10 IL1B IL6 TNF
7
Show member pathways
12.88 CFP CXCL8 IL1B IL6 IRAK4 NLRP3
8
Show member pathways
12.83 CD40LG IL1B IL6 IRAK4 TLR2 TLR9
9
Show member pathways
12.76 CCL4 CXCL8 IL1B IL6 TNF
10
Show member pathways
12.7 CD40LG IL1B IRAK4 TLR2 TLR9 TNF
11 12.69 CD40LG IL10 IL1B IRAK4 TLR2 TLR9
12
Show member pathways
12.68 CXCL1 CXCL8 IL6 MMP9 TLR2 TNF
13
Show member pathways
12.66 IL10 IL1B IL6 TLR2 TNF
14
Show member pathways
12.65 CXCL1 IL10 IL1B IL6 TNF
15
Show member pathways
12.51 CD40LG IL10 IL1B IL6 TNF
16
Show member pathways
12.47 CXCL1 CXCL8 IL1B IL6 MMP9 TLR2
17
Show member pathways
12.46 CCL4 CXCL8 IL10 IL1B IL6 IRAK4
18
Show member pathways
12.42 ALB CRP IL1B IL6 TNF
19
Show member pathways
12.41 CXCL8 IL6 IRAK4 TLR2 TLR9 TNF
20
Show member pathways
12.4 CD40LG IL10 IL1B IRAK4 TLR2 TNF
21
Show member pathways
12.38 CXCL8 IL1B IL6 IRAK4 TNF
22 12.34 IL10 IL1B IL6 IRAK4 TLR2 TLR9
23 12.29 IL6 MMP9 TLR2 TLR9 TNF
24 12.29 CXCL8 IL10 IL1B IL6 TNF
25
Show member pathways
12.29 CXCL8 IL1B IL6 IRAK4 TLR2 TLR9
26
Show member pathways
12.28 CXCL8 IL10 IL1B IL6 TNF
27 12.16 CXCL1 CXCL8 IL1B IL6 MMP9 TNF
28 12.13 CXCL8 IL10 IL1B IL6 MMP9 TNF
29 12.1 CXCL1 IL1B IL6 MMP9 TNF
30
Show member pathways
12.08 IL10 IL1B IL6 TLR2 TLR9 TNF
31 12.03 CCL4 CD40LG CXCL8 IL1B IRAK4 TNF
32 12.02 CXCL1 CXCL8 IL1B IL6
33 12 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
34 11.99 CXCL8 IL1B IL6 TNF
35 11.99 CCL4 CXCL1 CXCL8 IL1B IL6
36
Show member pathways
11.95 IL1B IL6 TLR2 TLR9
37 11.9 IL10 IL1B IL6 TLR9 TNF
38 11.81 IL10 IL1B TNF
39
Show member pathways
11.79 CD40LG CXCL8 TNF
40 11.78 CXCL1 CXCL8 IL10 IL1B IL6 TLR2
41 11.77 CD40LG IL10 IL6 TLR2 TLR9 TNF
42 11.73 CCL4 CXCL8 IL1B IL6 MMP9 TNF
43 11.71 CXCL8 IL6 MMP9
44
Show member pathways
11.71 CD40LG CXCL8 IL1B IL6 MMP9 TNF
45 11.62 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
46 11.58 IL6 MMP9 TNF
47 11.58 IL1B TLR2 TNF
48 11.58 CXCL8 IL10 IL1B IL6 IRAK4 NLRP3
49 11.55 IL1B IL6 TNF
50 11.5 IL10 IL1B IL6 TNF

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL4 CD40LG CFP CRP CXCL1
2 extracellular space GO:0005615 9.55 ADA ALB CCL4 CD40LG CFP CRP
3 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 LYZ MMP9
4 specific granule lumen GO:0035580 9.43 CFP CXCL1 LYZ

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B IRAK4 TLR9 TNF
2 defense response GO:0006952 9.97 CXCL1 CXCL8 NLRP3 TNF
3 defense response to bacterium GO:0042742 9.97 CFP IL10 LYZ MBL2 TLR9 TNF
4 immune response GO:0006955 9.96 CCL4 CD40LG CFP CXCL1 CXCL8 IL10
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.91 IL10 IL1B IL6 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL10 IL6 NLRP3 TNF
7 defense response to Gram-negative bacterium GO:0050829 9.9 IL6 LYZ TLR9
8 chemokine-mediated signaling pathway GO:0070098 9.9 CCL4 CXCL1 CXCL8
9 positive regulation of JNK cascade GO:0046330 9.9 IL1B TLR9 TNF
10 neutrophil chemotaxis GO:0030593 9.89 CCL4 CXCL8 IL1B
11 response to glucocorticoid GO:0051384 9.89 IL10 IL6 TNF
12 positive regulation of T cell proliferation GO:0042102 9.88 CD40LG IL1B IL6
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 IL6 IRAK4 TNF
14 toll-like receptor signaling pathway GO:0002224 9.85 IRAK4 TLR2 TLR9
15 acute-phase response GO:0006953 9.83 CRP IL6 MBL2
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 IRAK4 TLR2 TLR9
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR2 TNF
18 positive regulation of phagocytosis GO:0050766 9.79 IL1B MBL2 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.78 IL10 TLR9 TNF
20 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR2 TLR9 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.77 CD40LG TLR2 TLR9
22 positive regulation of interleukin-10 production GO:0032733 9.77 CD40LG TLR2 TLR9
23 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL6 TLR2 TLR9 TNF
24 positive regulation of NF-kappaB import into nucleus GO:0042346 9.76 IL1B TLR2 TLR9 TNF
25 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.75 IL10 MMP9 TNF
26 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
27 embryonic digestive tract development GO:0048566 9.73 ADA CXCL8 TNF
28 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR9 TNF
29 neutrophil mediated immunity GO:0002446 9.72 IL6 IRAK4
30 opsonization GO:0008228 9.72 CRP MBL2
31 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 MBL2 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 IL10 TNF
37 negative regulation of lipid storage GO:0010888 9.7 CRP IL6 TNF
38 defense response to Gram-positive bacterium GO:0050830 9.7 CRP IL6 LYZ MBL2 NLRP3 TLR2
39 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.69 IL6 NLRP3
40 negative regulation of interleukin-8 production GO:0032717 9.69 IL10 TLR9
41 interleukin-1 beta production GO:0032611 9.68 IL1B NLRP3
42 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
43 regulation of immunoglobulin secretion GO:0051023 9.68 CD40LG TNF
44 sequestering of triglyceride GO:0030730 9.67 IL1B TNF
45 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9
46 tumor necrosis factor production GO:0032640 9.66 TLR2 TLR9
47 positive regulation of toll-like receptor signaling pathway GO:0034123 9.66 TLR2 TLR9
48 receptor biosynthetic process GO:0032800 9.64 IL10 TNF
49 cytokine secretion involved in immune response GO:0002374 9.64 NLRP3 TLR2
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF

Molecular functions related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.76 ALB CCL4 CRP LACTB LYZ MMP9
2 chemokine activity GO:0008009 9.43 CCL4 CXCL1 CXCL8
3 cytokine activity GO:0005125 9.23 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
4 interleukin-1 receptor binding GO:0005149 9.13 IL1B IRAK4 TLR9

Sources for Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....