MCID: MNN013
MIFTS: 67

Meningitis malady

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Meningitis

Summaries for Meningitis

MedlinePlus : 41 meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. there are several types of meningitis. the most common is viral meningitis. you get it when a virus enters the body through the nose or mouth and travels to the brain. bacterial meningitis is rare, but can be deadly. it usually starts with bacteria that cause a cold-like infection. it can cause stroke, hearing loss, and brain damage. it can also harm other organs. pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. anyone can get meningitis, but it is more common in people with weak immune systems. meningitis can get serious very quickly. you should get medical care right away if you have a sudden high fever a severe headache a stiff neck nausea or vomiting early treatment can help prevent serious problems, including death. tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. antibiotics can treat bacterial meningitis. antiviral medicines may help some types of viral meningitis. other medicines can help treat symptoms. there are vaccines to prevent some of the bacterial infections that cause meningitis. nih: national institute of neurological disorders and stroke

MalaCards based summary : Meningitis is related to haemophilus meningitis and bacterial meningitis, and has symptoms including back pain, fever and headache. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

CDC : 3 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

NINDS : 51 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone can get encephalitis or meningitis.Inflammation from encephalitis and meningitis produce a wide range of symptoms.  Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia : 71 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 999)
id Related Disease Score Top Affiliating Genes
1 haemophilus meningitis 33.6 CFP MBL2 TLR9
2 bacterial meningitis 33.6 ALB CD40LG CRP IL6 TNF
3 measles 30.3 IL1B IL6 TNF
4 tuberculosis 30.2 CD40LG IL10 IL1B IL6 TLR9 TNF
5 hepatitis 30.2 IFNG IL10 IL6 TNF
6 labyrinthitis 30.1 CXCL8 IL10 IL1B IL6 TNF
7 cryptococcosis 30.0 CD40LG IL10 TNF
8 central nervous system lymphoma 29.8 IL10 IL1B IL6 TNF
9 status epilepticus 29.8 IFNG IL1B TNF
10 choroiditis 29.8 ALB CRP CXCL8 IL10 IL1B IL6
11 neuropathy 29.8 CRP CXCL8 IL1B IL6 TNF
12 astrocytoma 29.7 CD40LG IL10 TNF
13 chondroma 29.6 CRP IL6 TNF
14 uveitis 29.5 CD40LG LYZ TNF
15 spotted fever 29.5 CD40LG TLR2 TNF
16 proctitis 29.4 ALB IL6 MMP9 TLR9
17 chronic lymphocytic leukemia 29.4 IFNG IL1B TLR9 TNF
18 histiocytoma 29.4 CXCL8 MMP9 TNF
19 histiocytosis 29.3 CRP CXCL8 IL1B IL6 MMP9 TLR2
20 oculomotor nerve paralysis 29.3 CXCL8 IL1B IL6
21 migraine with aura 29.3 IL1B IL6 TNF
22 chorioretinitis 29.3 CD40LG IFNG IL10 TNF
23 hemolytic-uremic syndrome 29.3 ALB IFNG TNF
24 burns 29.3 CXCL8 IFNG IL10 IL6 MMP9 TNF
25 cataract 29.3 ALB CRP IL1B TNF
26 splenic marginal zone lymphoma 29.3 CXCL8 IL6 MMP9 TNF
27 fasciitis 29.2 CXCL8 MBL2 TLR2 TNF
28 microcephaly 29.2 IFNG IL10 TLR2 TNF
29 tularemia 29.2 CD40LG IFNG IL10 TLR9 TNF
30 causalgia 29.2 IFNG IL10 IL6 MMP9
31 pulmonary tuberculosis 29.2 CD40LG CXCL8 IFNG IL10 IL6 TNF
32 nasopharyngitis 29.2 CXCL8 IFNG IL1B IL6 TLR9 TNF
33 urticaria 29.2 ADA ALB CRP IL1B TNF
34 granulomatous hepatitis 29.1 CRP IL1B IL6
35 acute cholangitis 29.1 ALB CD40LG TNF
36 rheumatoid arthritis 28.9 CD40LG CRP CXCL1 CXCL8 IFNG IL10
37 myocardial infarction 28.9 ALB CRP IL10 IL1B IL6 MMP9
38 colon adenocarcinoma 28.7 ALB CRP CXCL8 IL10 IL1B IL6
39 membranoproliferative glomerulonephritis 28.7 ALB CD40LG CRP IL10 IL6 TLR9
40 aseptic meningitis 12.3
41 tuberculous meningitis 12.3
42 viral meningitis 12.3
43 meningococcal meningitis 12.2
44 fungal meningitis 12.1
45 mollaret meningitis 12.1
46 neonatal meningitis 12.1
47 cryptococcal meningitis 12.1
48 meningitis and encephalitis 12.0
49 syphilitic aseptic meningitis 12.0
50 pneumococcal meningitis 12.0

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:


back pain, fever, headache, hemiplegia, meningism, pain, pruritus, sciatica, seizures, syncope, tremor, chronic pain, hyperexplexia, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Meningitis:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ADA ALB CD40LG CFP CRP IFNG
2 immune system MP:0005387 10.36 TLR9 TNF ADA CD40LG CFP CRP
3 hematopoietic system MP:0005397 10.34 ADA CD40LG IFNG IL10 IL1B IL6
4 cardiovascular system MP:0005385 10.33 TLR2 TNF ADA CD40LG CFP CRP
5 cellular MP:0005384 10.28 ALB CD40LG IFNG IL10 IL6 IRAK4
6 digestive/alimentary MP:0005381 10.22 ADA ALB IFNG IL10 IL6 LYZ
7 endocrine/exocrine gland MP:0005379 10.21 ALB CD40LG IFNG IL10 IL6 LYZ
8 mortality/aging MP:0010768 10.21 IL1B IL6 LYZ MMP9 PTGDS TLR2
9 integument MP:0010771 10.13 CD40LG IFNG IL10 IL1B IL6 LYZ
10 liver/biliary system MP:0005370 10.01 ADA ALB IFNG IL10 IL6 LYZ
11 neoplasm MP:0002006 9.96 TNF ALB IFNG IL10 IL1B IL6
12 muscle MP:0005369 9.92 MMP9 TLR2 TNF ADA ALB IFNG
13 renal/urinary system MP:0005367 9.85 ADA ALB CD40LG IFNG IL6 LYZ
14 respiratory system MP:0005388 9.56 ADA IFNG IL10 IL6 LYZ MMP9
15 skeleton MP:0005390 9.4 IFNG IL10 IL1B IL6 LYZ MMP9

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 339)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 1 147-94-4 6253
3
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
4
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3 154598-52-4 64139
5
Zidovudine Approved Phase 4 30516-87-1 35370
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
7
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 14956 5280965
8
Fluconazole Approved Phase 4,Phase 3,Phase 2,Phase 1 86386-73-4 3365
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
11
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
12
Azathioprine Approved Phase 4 446-86-6 2265
13
Ceftriaxone Approved Phase 4,Phase 1 73384-59-5 5479530 5361919
14
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
15
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
16
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
17
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
18
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
19
Cosyntropin Approved Phase 4 16960-16-0 16129617
20
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
21
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
23 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
24 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Sodium Channel Blockers Phase 4
26 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 Gentamicins Phase 4,Phase 2,Phase 3
28 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
29 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
31 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
33 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
34 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
35 Hormones Phase 4,Phase 2,Phase 3,Phase 1
36 Diuretics, Potassium Sparing Phase 4
37 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
40 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
42 Anti-HIV Agents Phase 4,Phase 2,Phase 3
43 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
44 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Anticonvulsants Phase 4
46 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
49 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3
50 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 426)
id Name Status NCT ID Phase
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4
2 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
3 Determination of Gentamicin Dosing in Neonatal Patients Unknown status NCT00198601 Phase 4
4 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4
5 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4
6 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
7 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4
8 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4
9 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4
10 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
11 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4
12 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Completed NCT01119482 Phase 4
13 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
14 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
15 Descriptive, Post-marketing, Surveillance Safety Study of Menactra Vaccine Completed NCT00254995 Phase 4
16 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
17 Effect of Meningococcal Conjugate Vaccine on Meningococcal Carriage Completed NCT00119080 Phase 4
18 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
19 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
20 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
21 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
22 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4
23 Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
24 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
25 A Phase IV Study to Evaluate the Immunogenicity and Safety in UK Laboratory Workers of Menitorix Completed NCT00503165 Phase 4
26 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
27 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
28 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
29 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
30 Safety and Local Tolerability of Prevenar in Indian Children Completed NCT00488800 Phase 4
31 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
32 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
33 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
34 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
35 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4
36 Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time Completed NCT00581035 Phase 4
37 Evaluation of Meningococcal C Vaccine Programmes in Canadian Children Completed NCT00936962 Phase 4
38 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
39 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
40 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
41 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4
42 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Recruiting NCT02864927 Phase 4
43 Ciprofloxacin for the Prevention of Meningococcal Meningitis Active, not recruiting NCT02724046 Phase 4
44 Investigating the Immune Response to 4CMenB in Infants Active, not recruiting NCT02080559 Phase 4
45 Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients Active, not recruiting NCT01781871 Phase 4
46 A Study of the Interaction Between BCG And MenC Immunisation: BAM Active, not recruiting NCT02002156 Phase 4
47 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Active, not recruiting NCT02145624 Phase 4
48 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Not yet recruiting NCT02686853 Phase 4
49 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4
50 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Not yet recruiting NCT03087890 Phase 4

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Genetic Tests for Meningitis

Genetic tests related to Meningitis:

id Genetic test Affiliating Genes
1 Meningitis 29

Anatomical Context for Meningitis

MalaCards organs/tissues related to Meningitis:

39
Brain, Spinal Cord, Testes, T Cells, Bone, Pituitary, Neutrophil

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 5678)
id Title Authors Year
1
Recurrent meningitis with unusually delayed cerebrospinal fluid leak detected by magnetic resonance cisternography. ( 28084280 )
2017
2
An L-2-Hydroxyglutaric Aciduria Case Presented With Acute Bacterial Meningitis. ( 28141777 )
2017
3
Indocyanine green visualization of middle meningeal artery before craniotomy during surgical revascularization for moyamoya disease. ( 28050720 )
2017
4
Aseptic meningitis in relapsing polychondritis: a case report and literature review. ( 28361234 )
2017
5
The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host. ( 28042367 )
2017
6
Scrub typhus meningitis in a renal transplant recipient. ( 28356672 )
2017
7
Staphylococcus schleiferi Meningitis in an Infant. ( 28079841 )
2017
8
Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. ( 27886201 )
2017
9
Could the RTS,S/AS01 meningitis safety signal really be a protective effect of rabies vaccine? ( 28065475 )
2017
10
Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study. ( 28068915 )
2017
11
Corticosteroid-induced cryptococcal meningitis in patient without HIV. ( 28052943 )
2017
12
The use of mannitol in HIV-infected patients with symptomatic cryptococcal meningitis. ( 27725572 )
2017
13
Community-acquired bacterial meningitis. ( 27828810 )
2017
14
The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis. ( 27803171 )
2017
15
Emergence and control of epidemic meningococcal meningitis in sub-Saharan Africa. ( 28081671 )
2017
16
Surgical Resection during Chemotherapy of Pulmonary Cryptococcoma in a Patient with Cryptococcal Meningitis. ( 28050006 )
2017
17
Bacterial meningitis in alcoholic patients: A population-based prospective study. ( 28065808 )
2017
18
Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. ( 28049382 )
2017
19
Cerebrospinal fluid lens-free microscopy: a new tool for the laboratory diagnosis of meningitis. ( 28045084 )
2017
20
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 28086930 )
2017
21
Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. ( 28063937 )
2017
22
Recent advances in the diagnosis and management of tuberculous meningitis. ( 27798497 )
2017
23
Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. ( 28077083 )
2017
24
Can We Rule Out Meningitis from Negative Jolt Accentuation? A Retrospective Cohort Study. ( 28055104 )
2017
25
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
26
Increased activity of the complement system in cerebrospinal fluid of the patients with Non-HIV Cryptococcal meningitis. ( 28052761 )
2017
27
Tuberculous meningitis and hydrocephalus in Filippino de' Medici. ( 28504108 )
2017
28
Salmonella Enterica Serotype Enteritidis Vertebral Osteomyelitis and Epidural Abscess Complicated with Meningitis. ( 27628612 )
2016
29
Successful treatment of refractory listeria meningitis and bacteremia with trimethoprim-sulfamethoxazole in an immunocompetent child. ( 27976567 )
2016
30
Investigation of the Selection and Timing of Pharmacological Therapy in Community-Acquired Bacterial Meningitis. ( 27408520 )
2016
31
Multitargeted loop-mediated isothermal amplification for rapid diagnosis of tuberculous meningitis. ( 27084816 )
2016
32
Fatal Meningitis in a 14-Month-Old with Currarino Triad. ( 27597920 )
2016
33
Outbreak of Elizabethkingia meningoseptica sepsis with meningitis in a well-baby nursery. ( 28077242 )
2016
34
Pneumococcal meningitis outbreaks in sub-Saharan Africa. ( 27305709 )
2016
35
Repeated therapeutic lumbar punctures in cryptococcal meningitis - necessity and/or opportunity? ( 27607912 )
2016
36
Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature. ( 26927892 )
2016
37
Neisseria meningitidis and Streptococcus pneumoniae as leading causes of pediatric bacterial meningitis in nine Mexican hospitals following 3 years of active surveillance. ( 27551428 )
2016
38
Hyponatremia in children with tuberculous meningitis: A hospital-based cohort study. ( 27857783 )
2016
39
Occipital dermoid cyst associated with dermal sinus complicated with meningitis: A case report. ( 26724977 )
2016
40
Hydrocephalus in tuberculous meningitis - how late can it present? ( 27417414 )
2016
41
Surgically Cured, Relapsed Pneumococcal Meningitis Due to Bone Defects, Non-invasively Identified by Three-dimensional Multi-detector Computed Tomography. ( 27980270 )
2016
42
Eosinophilic meningitis triggered by implanted Gliadel wafers: case report. ( 27285546 )
2016
43
Callosal disconnection syndrome after ischemic stroke of the corpus callosum due to meningococcal meningitis: A case report. ( 27653875 )
2016
44
Mycobacterium abscessus as a Cause of Chronic Meningitis: A Rare Clinical Entity. ( 27079354 )
2016
45
Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein. ( 26986770 )
2016
46
Diarrhea-associated pneumococcal meningitis with complicating hydrocephalus in a child in a resource-limited setting. ( 27580337 )
2016
47
Prognostic Modeling of Bacterial Meningitis: The Search for More Precision. ( 27927862 )
2016
48
Laboratory diagnosis and genetic analysis of a family clustering outbreak of aseptic meningitis due to echovirus 30. ( 27646838 )
2016
49
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. ( 27350332 )
2016
50
Fulminant bacterial meningitis due to Neisseria meningitidis with no pleocytosis on lumbar puncture. ( 27567424 )
2016

Variations for Meningitis

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CD40LG CFP CRP CXCL1 CXCL8 IFNG
2
Show member pathways
13.54 CD40LG CXCL1 CXCL8 IL10 IL1B IL6
3
Show member pathways
13.49 CD40LG CXCL1 CXCL8 IFNG IL10 IL1B
4
Show member pathways
13.35 CD40LG CXCL1 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.12 CXCL1 CXCL8 IL1B IL6 IRAK4 TLR2
6
Show member pathways
12.98 CD40LG CXCL8 IFNG IL10 IL1B IL6
7
Show member pathways
12.92 CFP CXCL8 IFNG IL1B IL6 IRAK4
8
Show member pathways
12.84 CD40LG IL1B IL6 IRAK4 TLR2 TLR9
9
Show member pathways
12.84 CXCL8 IFNG IL10 IL1B IL6 IRAK4
10
Show member pathways
12.77 CXCL8 IFNG IL1B IL6 TNF
11
Show member pathways
12.72 CD40LG IL1B IRAK4 TLR2 TLR9 TNF
12
Show member pathways
12.72 IFNG IL10 IL1B IL6 TLR2 TNF
13
Show member pathways
12.71 CXCL1 IFNG IL10 IL1B IL6 TNF
14 12.68 CD40LG IFNG IL10 IL1B IRAK4 TLR2
15
Show member pathways
12.58 CD40LG IFNG IL10 IL1B IL6 TNF
16
Show member pathways
12.47 ALB CRP IFNG IL1B IL6 TNF
17
Show member pathways
12.44 CXCL1 CXCL8 IFNG IL1B IL6 MMP9
18
Show member pathways
12.41 CXCL8 IL6 IRAK4 TLR2 TLR9 TNF
19
Show member pathways
12.41 CXCL8 IFNG IL1B IL6 IRAK4 TNF
20
Show member pathways
12.41 CD40LG IFNG IL10 IL1B IRAK4 TLR2
21 12.33 IFNG IL6 MMP9 TLR2 TLR9 TNF
22 12.31 CXCL8 IL10 IL1B IL6 TNF
23 12.31 IFNG IL10 IL1B IL6 IRAK4 TLR2
24
Show member pathways
12.3 CXCL8 IFNG IL10 IL1B IL6 TNF
25
Show member pathways
12.22 CXCL8 IFNG IL1B IL6 IRAK4 TLR2
26 12.17 IFNG IL1B MMP9 TNF
27 12.16 CXCL1 CXCL8 IFNG IL1B IL6 MMP9
28 12.14 CXCL8 IL10 IL1B IL6 MMP9 TNF
29 12.11 CXCL1 IL1B IL6 MMP9 TNF
30 12.1 CXCL1 CXCL8 IFNG IL1B IL6
31 12.09 IFNG IL10 IL6 TNF
32
Show member pathways
12.07 IFNG IL1B IL6 TLR2 TLR9
33
Show member pathways
12.05 IFNG IL10 IL1B IL6 TLR2 TLR9
34 12.03 CD40LG CXCL8 IL1B IRAK4 TNF
35 12.01 CXCL8 IL1B IL6 TNF
36 11.98 CXCL1 CXCL8 IFNG IL1B IL6
37 11.93 IFNG IL10 IL1B IL6 TLR9 TNF
38 11.93 CXCL1 CXCL8 IFNG IL1B IL6 TLR2
39 11.92 CXCL8 IL10 IL1B IL6 IRAK4 TNF
40 11.91 IFNG IL10 IL1B TNF
41
Show member pathways
11.89 CD40LG CXCL8 IFNG TNF
42 11.87 CD40LG IL10 IL6 TLR2 TLR9 TNF
43 11.83 CXCL8 IL1B IL6 MMP9 TNF
44 11.74 IFNG IL10 IL6
45 11.74 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
46 11.72 CXCL8 IL6 MMP9
47 11.68 IFNG IL1B TLR2 TNF
48 11.66 CXCL1 CXCL8 IL10 IL1B IL6 TNF
49 11.65 CXCL8 IFNG IL6
50 11.65 IFNG IL1B IL6 TNF

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CD40LG CFP CRP CXCL1 CXCL8
2 external side of plasma membrane GO:0009897 9.65 ADA CD40LG IFNG IL6 TNF
3 extracellular space GO:0005615 9.58 ADA ALB CD40LG CFP CRP CXCL1
4 specific granule lumen GO:0035580 9.5 CFP CXCL1 LYZ
5 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 LYZ MMP9

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 IFNG IL1B MMP9 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.97 CXCL8 IFNG IL10 IL6 TNF
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.95 IL10 IL1B IL6 TNF
4 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
5 response to insulin GO:0032868 9.91 IL10 IL6 TLR2
6 regulation of insulin secretion GO:0050796 9.91 IFNG IL1B TNF
7 positive regulation of JNK cascade GO:0046330 9.9 IL1B TLR9 TNF
8 neutrophil chemotaxis GO:0030593 9.9 CXCL8 IFNG IL1B
9 positive regulation of T cell proliferation GO:0042102 9.9 CD40LG IFNG IL1B IL6
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 IL6 IRAK4 TNF
11 humoral immune response GO:0006959 9.89 IFNG IL6 TNF
12 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 MBL2 TLR2 TNF
13 positive regulation of tumor necrosis factor production GO:0032760 9.87 IFNG TLR2 TLR9
14 defense response to bacterium GO:0042742 9.87 CFP IFNG IL10 LYZ MBL2 TLR9
15 toll-like receptor signaling pathway GO:0002224 9.86 IRAK4 TLR2 TLR9
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IFNG IL1B IL6 TNF
17 acute-phase response GO:0006953 9.85 CRP IL6 MBL2
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 IRAK4 TLR2 TLR9
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 IL1B TLR2 TNF
20 positive regulation of phagocytosis GO:0050766 9.83 IL1B MBL2 TNF
21 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR9 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR9 TNF
23 positive regulation of interleukin-10 production GO:0032733 9.81 CD40LG TLR2 TLR9
24 positive regulation of interleukin-12 production GO:0032735 9.81 CD40LG IFNG TLR2 TLR9
25 defense response to protozoan GO:0042832 9.8 IFNG IL10 IL6
26 embryonic digestive tract development GO:0048566 9.79 ADA CXCL8 TNF
27 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.79 IL10 MMP9 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.78 IFNG IL1B TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL1B TLR2 TLR9 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.76 IFNG IL1B TNF
32 negative regulation of lipid storage GO:0010888 9.75 CRP IL6 TNF
33 neutrophil mediated immunity GO:0002446 9.74 IL6 IRAK4
34 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
35 opsonization GO:0008228 9.73 CRP MBL2
36 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR9 TNF
37 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.72 ADA PTGDS
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.72 IFNG IL1B
39 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
40 regulation of defense response to virus by host GO:0050691 9.72 IFNG IL1B
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IFNG IL10
42 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
44 negative regulation of growth of symbiont in host GO:0044130 9.71 IFNG IL10 MBL2 TNF
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.7 IL6 TNF
46 negative regulation of interleukin-8 production GO:0032717 9.7 IL10 TLR9
47 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 CD40LG IL1B IL6 IRAK4 TLR2 TLR9
48 positive regulation of fever generation GO:0031622 9.69 IL1B TNF
49 regulation of immunoglobulin secretion GO:0051023 9.69 CD40LG TNF
50 sequestering of triglyceride GO:0030730 9.68 IL1B TNF

Molecular functions related to Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CD40LG CXCL1 CXCL8 IFNG IL10 IL1B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1B IRAK4 TLR9

Sources for Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....