Meningitis malady

MedlinePlus: Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. there are several types of meningitis. the most common is viral meningitis, which you get when a virus enters the body through the nose or mouth and travels to the brain. bacterial meningitis is rare, but can be deadly. it usually starts with bacteria that cause a cold-like infection. it can block blood vessels in the brain and lead to stroke and brain damage. it can also harm other organs. pneumococcal infections and meningococcal infections can cause bacterial meningitis. anyone can get meningitis, but it is more common in people whose bodies have trouble fighting infections. meningitis can progress rapidly. you should seek medical care quickly if you have a sudden fever a severe headache a stiff neck early treatment can help prevent serious problems, including death. vaccines can prevent some of the bacterial infections that cause meningitis. parents of adolescents and students living in college dorms should talk to a doctor about the vaccination. nih: national institute of neurological disorders and stroke²³

MalaCards: Meningitis is related to bacterial meningitis and tuberculous meningitis. An important gene associated with Meningitis is NF2 (neurofibromin 2 (merlin)), and among its related pathways are TRAF Pathway and STAT3 Pathway. The compounds atp and peptidoglycan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord, and related mouse phenotypes are respiratory system and mortality/aging.

Disease Ontology: Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. it can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. meningitis is a diffuse infection caused by a variety of different agents.⁶

NINDS: Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.³¹

Wikipedia: Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known...⁴⁴ more...

Aliases & Descriptions:

meningitis 6 31 8 32 23 43

Diseases related to meningitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1085)

id	Related Disease	Score	Top Affiliating Genes
1	bacterial meningitis	39.1	PIK3C2A, CKB, LBP, LACTB, CFP, MMP8
2	tuberculous meningitis	37.3	ZNF32, JTB, IL10, IL1B, IL8, MBL2
3	viral meningitis	35.9	CD14, GUSB, IL16, IL6, CCL5, NTF3
4	aseptic meningitis	35.6	CHKB, CD9, GUSB, IL1R1, CCL3, NLRP3
5	meninges hemangiopericytoma	34.2	NCAM1, RB1, VIM, MUC1, CDH1, IGF2
6	pneumonia	34.0	PIK3C2A, BTK, SELE, SELL, SERPINA1, VIM
7	hemangiopericytoma	33.9	NCAM1, RB1, VIM, VEGFA, MUC1, S100B
8	meningitis and encephalitis	33.3	CAT, NTF3, NTF4, CRP, SOD1, GDNF
9	encephalitis	33.1	PIK3CG, SELE, VEGFA, MYD88, BMP6, CHI3L1
10	eosinophilic meningitis	32.6	MMP9, IL10, IL2, IL4, IL5, CCL24
11	fungal meningitis	32.4	PIGK, ISYNA1, CCDC115, GPR180, IFNG, CYP20A1
12	tuberculosis	32.4	IL10, IL12B, IL1B, IL4, MBL2, CCL2
13	haemophilus influenzae	32.3	PIK3CG, VDAC1, CMAS, BAMBI, LBP, LACTB
14	meningococcal infection	32.1	CFP, GSR, IL10, IL1B, IL8, TNF
15	klebsiella	31.3	VDAC1, LACTB, MPO, CD79A, CD40LG, MMP9
16	immunodeficiency	31.0	BTK, SELL, VIP, MYD88, BMP6, PARP1
17	sepsis	30.9	SELE, SELL, VDAC1, MYD88, PAFAH1B1, LBP
18	lymphocytic choriomeningitis	30.9	MYD88, CD4, IL2, IL7, IFNA1, IFNG
19	meningoencephalitis	30.8	CIR1, CHKB, B2M, CD79A, CD4, CD40LG
20	neisseria meningitidis infection	30.6	LACTB, CFP, CD46, FCGR2A, IL1R1, MBL2
21	encephalomyelitis	30.4	VIP, VEGFA, BMP6, S100B, MPO, MPZ
22	mumps	30.1	CFB, CD79A, CD4, CD40LG, CD46, IL1B
23	adult t-cell leukemia	29.7	NCAM1, CD4, IL16, IL2, IL2RA, IL2RB
24	influenza	29.7	PIK3R5, PIK3C2A, PIK3CG, SELL, VDAC1, MYD88
25	parotitis	29.0	CD79A, MMP2, MMP9, HSF4, CRP, LTF
26	cryptococcosis	28.9	SELL, CIR1, CD4, CD40LG, FCGR2A, IL10
27	angiostrongyliasis	28.9	MMP9, IL13, IL2, IL4, IL5, CCL24
28	lymphopenia	28.8	SELL, B2M, CD4, CD55, GSR, IL10
29	t-cell leukemia	28.7	PIK3CG, CD4, IL16, IL1A, IL2, IL2RA
30	sarcoidosis	28.7	PIK3C2A, SELE, SELL, VIM, VEGFA, CHI3L1
31	chronic granulomatous disease	28.7	CFP, MPO, IFNG, CAT, G6PD, SOD1
32	neurologic diseases	28.6	PARP1, CKB, CHI3L1, XDH, B2M, MPZ
33	multiple sclerosis	28.6	NCAM1, PCNA, SELE, SELL, VIM, VIP
34	multidrug-resistant tuberculosis	28.6	INHA, IL10, IL1A, IL2, IL4, IL6
35	shigellosis	28.4	VDAC1, MPO, CD79A, CD248, IRAK4, IL1B
36	hemolytic anemia	28.3	LACTB, CD47, CD55, APOH, IFNA2, CR1
37	thrombocytopenia	28.1	PIK3C2A, NCAM1, SELE, SELL, BMP6, CFB
38	hepatitis	28.0	SERPINA1, XDH, GUSB, GSR, IL2RB, IFNA1
39	hypoglycemia	28.0	PIK3CG, PCNA, VIM, VEGFA, CKB, CHKB
40	acute lymphoblastic leukemia	28.0	BTK, RB1, SELL, MPO, CD9, GUSB
41	behcet's disease	28.0	SELE, SELL, IL2RA, IL8, APOH, MBL2
42	meningioma	27.9	PIK3CG, NCAM1, PCNA, RB1, SELE, VIM
43	tick-borne encephalitis	27.9	B2M, GSR, ENO2, CCL2, CCL3, IGHV4-39
44	neuritis	27.8	BMP6, MPO, MPZ, MOG, CD40LG, MMP9
45	convulsions	27.7	PIK3C2A, XDH, IL1B, IL1R1, IL6, APOE
46	central nervous system disease	27.4	CKB, MOG, IL17A, APP, MBP, CCL2
47	thrombocytosis	27.3	VEGFA, CD79A, CD40LG, IL1A, IL1B, IL4
48	vasculitis	27.2	SELE, SELL, SERPINA1, VEGFA, BMP6, SAA4
49	multiple myeloma	27.1	PIK3CG, NCAM1, PCNA, RB1, VEGFA, MYD88
50	purpura	26.9	SELE, VEGFA, BMP6, LACTB, CFB, CFI

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to meningitis:

²²

MGI Mouse Phenotypes related to meningitis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	INF	SELL, VANGL1, FST, CD14, FLNA, ARRB2
2	mortality/aging	MP:0010768	INF	PIK3C2A, NCAM1, BTK, RB1, SELE, VEGFA
3	hematopoietic system phenotype	MP:0005397	11.6	PCNA, BTK, MYD88, LGALS9, ZBTB17, LAMA2
4	craniofacial phenotype	MP:0005382	10.5	BAMBI, LAMA2, SATB2, FST, IRF6, FLNA
5	normal phenotype	MP:0002873	10.5	SELE, VIP, VEGFA, VANGL1, YWHAG, BAMBI
6	reproductive system phenotype	MP:0005389	10.2	VIP, VEGFA, VANGL1, PAFAH1B1, LAMA2, B2M
7	liver/biliary system phenotype	MP:0005370	9.9	VEGFA, LBP, FLNA, IL1R1, IL2, IL6
8	limbs/digits/tail phenotype	MP:0005371	9.7	BTK, RB1, VEGFA, VANGL1, CHKB, BAMBI
9	immune system phenotype	MP:0005387	9.5	PIK3R5, BTK, SELL, VIM, MYD88, LGALS9
10	skeleton phenotype	MP:0005390	9.1	PIK3CG, RB1, VEGFA, MYD88, BMP6, LGALS9
11	other phenotype	MP:0005395	8.8	LAMA2, LAMC2, CD40LG, FN1, IL13, IL2
12	tumorigenesis	MP:0002006	8.7	BTK, RB1, SELL, MYD88, MUC1, B2M
13	no phenotypic analysis	MP:0003012	8.0	PCNA, RB1, VEGFA, MYD88, PARP1, LGALS9
14	integument phenotype	MP:0010771	7.9	PIK3CG, BTK, RB1, PARP1, ZBTB17, MUC1
15	adipose tissue phenotype	MP:0005375	7.6	PIK3C2A, RB1, MYD88, XDH, CD14, GUSB
16	nervous system phenotype	MP:0003631	INF	RB1, VDAC1, VANGL1, MYD88, PAFAH1B1, PARP1
17	growth/size phenotype	MP:0005378	INF	PIK3C2A, PIK3CG, BTK, RB1, SELE, VDAC1
18	behavior/neurological phenotype	MP:0005386	INF	NCAM1, RB1, SELE, VIM, VIP, VDAC1
19	vision/eye phenotype	MP:0005391	INF	NCAM1, RB1, SELE, VIM, VEGFA, MYD88
20	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, RB1, SELE, SELL, VIM, VEGFA
21	endocrine/exocrine gland phenotype	MP:0005379	INF	SELL, PAFAH1B1, LAMA2, SATB2, XDH, CD40LG
22	hearing/vestibular/ear phenotype	MP:0005377	INF	RB1, VANGL1, MYD88, PARP1, LAMA2, LAMC2
23	digestive/alimentary phenotype	MP:0005381	INF	BTK, RB1, VEGFA, MUC1, LAMC2, SATB2
24	muscle phenotype	MP:0005369	INF	PIK3CG, RB1, VIM, VEGFA, CHKB, LAMA2
25	renal/urinary system phenotype	MP:0005367	INF	MYD88, LAMC2, CFB, CFI, AVP, CD55
26	cellular phenotype	MP:0005384	INF	PIK3R5, PIK3CG, NCAM1, PCNA, BTK, RB1
27	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PIK3CG, BTK, RB1, SELE, SELL

Articles related to meningitis:

(show top 50)    (show all 385)

id	Title	Authors	Year	Affiliating Genes
1	Extracellular loops of the Eschericia coli outer memb rane protein A contribute to the pathogenesis of meningitis. (21148506)	Maruvada R.... Kim K.S.	2011	PLA2G4A
2	Laboratory diagnosis of bacterial meningitis: useful ness of various tests for the determination of the etiological agent (19398286)	Carbonnelle E.	2009	CRP
3	Two cases of bacterial meningitis accompanied by thal idomide therapy in patients with multiple myeloma: is thalidomide associated wi th bacterial meningitis? (18621563)	Pasa S.... Ayyildiz O.	2009	TNF
4	Dexamethasone regulation of matrix metalloproteinase expression in experimental pneumococcal meningitis. (18374903)	Liu X.... Li Z.	2008	MMP9
5	C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. (18581011)	Hemmati F.... Pishva N.	2008	CRP
6	A case of Listeria meningitis associated with increased adenosine deaminase in cerebrospinal fluid. (17141462)	Nishida Y.... Mizusawa H.	2007	ADA
7	Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. (17381860)	Shih P.C.... Shiow S.J.	2007	MMP9
8	Differential diagnosis of bacterial and viral meningitis in childhood acute meningitis: a statistical model (17427553)	Celik N.... Zorlu P.	2007	CRP
9	Treatment of neoplastic meningitis with intrathecal 9 -nitro-camptothecin. (17062987)	Ochiai H.... Sampson J.H.	2006	TOP1
10	Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fluid cytokines. (17139119)	Nagafuchi M.... Ichiyama T.	2006	IL6
11	Total antioxidant/oxidant status in meningism and meningitis. (17138006)	Aycicek A.... Selek S.	2006	CAT, ALB, CP
12	Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4. (15520784)	Enders A.... Ehl S.	2004	IRAK4
13	Continuous occurrence of two cases of Haemophilus in fluenzae type b meningitis caused by different strains in a day nursery (14515758)	Hoshino T.... Kohno Y.	2003	LACTB
14	Transient elevation of interleukin-16 levels at the initial stage of meningitis in children. (12605702)	Suzuki T.... Shimbo T.	2003	IL16
15	Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. (11891827)	Koedel U.... Pfister H.W.	2002	CASP1
16	Levels of matrix metalloproteinase-9 within cerebrospinal fluid in a rabbit model of coccidioidal meningitis and vasculitis. (12447750)	Williams P.L.... Stevens D.A.	2002	MMP9
17	Does the estimation of acute phase protein concentrations in cerebrospinal fluid and/or in serum in patients with viral meningitis carry diagnostic importance? Part I. Lymphocytic meningitis caused by epidemic parotitis (12666587)	A8obos M.... Piatas S.	2002	CRP
18	Immunohistochemical and ultrastructural study of gap junction proteins connexin26 and 43 in human arachnoid villi and meningeal tumors. (12484567)	Arishima H.... Kubota T.	2002	GJA1, GJB2
19	Meningeal carcinomatosis from an ovarian primary with complete response to adjuvant chemotherapy after cranial irradiation. (11706787)	Ohta H.... Yonesaka A.	2001	MUC16
20	CSF interleukin-1 beta, tumor necrosis factor-alpha and free radicals production in relation to clinical outcome in acute bacterial meningitis. (10869140)	Jain M.... Randhava V.S.	2000	SOD1, PIK3C2A
21	Meningeal cells can communicate with astrocytes by calcium signaling. (10632097)	Grafstein B.... Nedergaard M.	2000	CANT1
22	Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis. (10641604)	Mizuno Y.... Hara T.	2000	NTF3
23	Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study. (9923556)	Nakagawa H.... Ikenaka K.	1999	RNGTT, TKT, TYMP
24	Mannose-binding protein B allele confers protection against tuberculous meningitis. (10203135)	Hoal-Van Helden E.G.... Van Helden P.D.	1999	MBL2
25	C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. (10356141)	Sormunen P.... Peltola H.	1999	CRP
26	Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis. (10224177)	Maffei F.A.... Carcillo J.A.	1999	LTF
27	In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors. (9524089)	Yamada M.... Ikenaka K.	1998	RNGTT, TKT, TYMP
28	A combination of thalidomide plus antibiotics protect s rabbits from mycobacterial meningitis-associated death. (9607834)	Tsenova L.... Kaplan G.	1998	TNF
29	Procalcitonin, C-reactive protein and interleukin 6 in bacterial and viral meningitis in children (9767794)	Gendrel D.... Bohuon C.	1998	IL6
30	Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis (9800479)	Shimetani N.... Ohtani H.	1998	CRP, SAA4
31	Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1. (9368600)	Lahrtz F.... Fontana A.	1997	CCL5, CXCR3, IL16
32	The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. (9396559)	Inaba Y.... Shimbo T.	1997	IL8, CCL3
33	Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis. (9223915)	Ceyhan M.... MA1ftA1oA9lu O.	1997	IL1B
34	Cytokine profiles in cerebrospinal fluid of human immunodeficiency virus-infected patients with cryptococcal meningitis: no leukocytosis despite high interleukin-8 levels. University of Zimbabwe Meningitis Group. (9395381)	Chaka W.... Hoepelman A.I.	1997	IL8
35	The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. (9351573)	Perry A.... Nascimento A.G.	1997	DES
36	Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis. (9029645)	Beratis N.G.... Syrogiannopoulos G.A.	1997	GUSB
37	Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis (9424322)	Kepa L.... Adamek B.	1997	CRP
38	The enzyme activity and pyruvate, lactate and 2,3-DPG levels in the erythrocytes of patients with severe forms of meningococcal infection and suppurative meningitis (8771662)	Martynov V.A.... Kolobaeva O.V.	1996	GSR, G6PD
39	The value of C-reactive protein for the differentiation of bacterial meningitis from viral meningitis (9524672)	Diculencu D.... Buiuc D.	1995	CRP
40	Tumor necrosis factor-alpha and interleukin-1 beta in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole. National Institute of Allergy and Infectious Diseases Mycoses Study Group. (7769317)	Ampel N.M.... Cloud G.A.	1995	IL1B
41	Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. (7756471)	LA^pez-CortAcs L.F.... Castillo J.	1995	ADA
42	C-reactive protein (CRP) and its significance in purulent meningitis (8584095)	PrzyjaA8kowski W.... Janeczko J.	1995	CRP
43	The use of cytokine and C-reactive protein measurements in cerebrospinal fluid during acute infective meningitis. (8067666)	Stearman M.... Southgate H.J.	1994	TNF, IL6, CRP
44	Meningeal carcinomatosis in patients with small cell lung cancer (8391093)	Ohnoshi T.... Kimura I.	1993	ENO2
45	Meningeal malignant melanoma in a child: immunocytolo gical diagnosis. (1621523)	Koyama T.... Murakami M.	1992	IFNB1
46	Tumor cell dissemination triggers an intrathecal immune response in neoplastic meningitis. (1371713)	Weller M.... WiethAPlter H.	1992	FN1, AFP, CEACAM3
47	Cerebrospinal fluid interleukin-6 and IgE in bacterial and viral meningitis. (1580206)	Perrella O.... Faella F.	1992	IL6
48	Barrier functions of the leptomeninges: a study of normal meninges and meningiomas in tissue culture. (1722030)	Feurer D.J.... Weller R.O.	1991	GLUL
49	Cefuroxime treatment failure of nontypable Haemophilus influenzae meningitis associated with alteration of penicillin-binding proteins. (2230238)	Mendelman P.M.... Rubin L.G.	1990	PKD1
50	Prognostic significance of cerebrospinal fluid adenosine deaminase in acute bacterial meningitis. (2332247)	da Cunha J.G.... da Costa R.C.	1990	ADA

Genes related to meningitis according to GeneCards:

(show top 50)    (show all 294)

id	Symbol	Description	Score	GeneCards Section Context
1	NF2	neurofibromin 2 (merlin)	11.1	Summaries, Publications
2	ADA	adenosine deaminase	11.0	Publications
3	CRP	C-reactive protein, pentraxin-related	11.0	Publications
4	IL8	interleukin 8	11.0	Publications
5	CFP	complement factor properdin	11.0	Publications
6	GUSB	glucuronidase, beta	11.0	Publications
7	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
8	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
9	IL10	interleukin 10	11.0	Publications
10	CAT	catalase	11.0	Publications
11	TNF	tumor necrosis factor	11.0	Publications
12	LACTB	lactamase, beta	11.0	Publications
13	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
14	IL1B	interleukin 1, beta	11.0	Publications
15	TLR2	toll-like receptor 2	11.0	Publications
16	IFNG	interferon, gamma	11.0	Publications
17	LYZ	lysozyme	11.0	Publications
18	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
19	NTF3	neurotrophin 3	11.0	Publications
20	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
21	SOD1	superoxide dismutase 1, soluble	11.0	Publications
22	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
23	GPR180	G protein-coupled receptor 180	11.0
24	CKB	creatine kinase, brain	11.0	Publications
25	CFI	complement factor I	11.0	Publications
26	IRAK4	interleukin-1 receptor-associated kinase 4	11.0	Publications
27	YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	11.0	Publications
28	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
29	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
30	NLRP3	NLR family, pyrin domain containing 3	11.0
31	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
32	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
33	SATB2	SATB homeobox 2	11.0
34	LBP	lipopolysaccharide binding protein	11.0	Publications
35	DES	desmin	11.0	Publications
36	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
37	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
38	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
39	GDNF	glial cell derived neurotrophic factor	11.0	Publications
40	S100B	S100 calcium binding protein B	11.0	Publications
41	VIM	vimentin	11.0	Publications
42	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
43	IL1R1	interleukin 1 receptor, type I	11.0	Publications
44	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
45	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
46	IL4	interleukin 4	11.0	Publications
47	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0	Publications
48	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
49	IGKV1-33	immunoglobulin kappa variable 1-33	11.0
50	CCDC115	coiled-coil domain containing 115	11.0

Pathways related to meningitis according to GeneDecks:

(show top 50)    (show all 118)

id	Pathway	Score	Top Affiliating Genes
1	TRAF Pathway36	11.7	MYD88, IRAK4, IL12B, IL1A, IL1B, IL1R1
2	STAT3 Pathway36	11.6	BTK, BMP6, CD4, IL10, IL12B, IL13
3	Akt Signaling36	11.5	PIK3CG, BTK, CD4, IL10, IL12B, IL16
4	Chemokine Signaling36	11.5	ARRB2, IL8, MAPK10, CCL8, CCL4, CCL2
5	Immune response_TLR signaling pathways41	11.4	MYD88, LBP, CD14, FN1, IRAK4, IL4
6	Complement and coagulation cascades20	11.3	SERPINA1, CFB, CFI, CD55, CD46, MBL2
7	PGC1Alpha Pathway36	11.3	BTK, BMP6, CD4, IL12B, IL13, IL16
8	Immune response Alternative complement pathway10	11.3	CFB, CFI, CFP, CD55, CD46, CR1
9	PEDF Induced Signaling36	11.3	BTK, BMP6, IL10, IL12B, IL13, IL16
10	RAR-Gamma-RXR-Alpha Degradation36	11.3	BTK, IL16, IL2, IL7, MAPK10, CCL8
11	Pertussis20	11.3	MYD88, CD14, IRAK4, IL10, IL12B, IL1A
12	IL-6 Pathway36	11.2	BTK, BMP6, IL10, IL12B, IL16, IL4
13	Immune response_Alternative complement pathway41	11.2	CFB, CFI, CFP, CD55, CD46, CR1
14	MIF Mediated Glucocorticoid Regulation36	11.2	BTK, BMP6, CD14, MIF, IL10, IL12B
15	Bacterial infections in CF airways41	11.2	MYD88, MUC1, LBP, IRAK4, IL1R1, TLR2
16	all-trans-Retinoic Acid Signaling in Brain36	11.1	BTK, BMP6, IL10, IL12B, IL13, IL16
17	Toll-like receptor signaling pathway20	11.0	PIK3R5, PIK3CG, MYD88, LBP, CD14, IRAK4
18	Regulation of eIF4 and p70S6K36	10.9	BTK, CD4, IL12B, IL13, IL16, IL1A
19	Glucocorticoid Receptor Signaling36	10.8	BTK, BMP6, CD4, IL10, IL12B, IL13
20	Rheumatoid arthritis20	10.7	VEGFA, MMP3, IL17A, IL1A, IL1B, IL6
21	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.7	MYD88, LBP, CD14, IRAK4, IL6, IFNB1
22	SOCS Pathway36	10.6	BTK, BMP6, CD4, IL10, IL12B, IL13
23	NFAT Signaling and Lymphocyte Interactions36	10.6	BTK, BMP6, CD4, IL12B, IL13, IL16
24	Cytokine Network36	10.6	IL10, IL12B, IL13, IL16, IL1A, IL1B
25	Tuberculosis20	10.5	MYD88, LBP, CD14, IRAK4, FCGR2A, IL10
26	Endothelin-1 Signaling Pathway36	10.5	BTK, BMP6, IL10, IL12B, IL13, IL16
27	Influenza A20	10.5	PIK3R5, PIK3CG, VDAC1, MYD88, IRAK4, IL12B
28	Rho Family GTPases36	10.4	BTK, VIM, BMP6, LAMA2, LAMC2, CDH1
29	MIF Regulation of Innate Immune Cells36	10.4	BTK, BMP6, CD14, MIF, IL10, IL12B
30	Immune response MIF in innate immunity response10	10.3	MYD88, LBP, CD14, IRAK4, MIF, IL1B
31	Immune response_MIF in innate immunity response41	10.3	MYD88, LBP, CD14, IRAK4, MIF, IL1B
32	PAK Pathway36	10.3	BTK, BMP6, IL10, IL12B, IL13, IL16
33	Hematopoietic cell lineage20	10.3	CD14, CD4, CD9, CD55, IL1A, IL1B
34	Antioxidant Action of Vitamin-C36	10.2	BTK, BMP6, CD4, FLNA, IL10, IL12B
35	Amoebiasis20	10.2	PIK3R5, LAMA2, LAMC2, CD14, FN1, IL12B
36	Malaria20	10.1	SELE, MYD88, CD40LG, IL10, IL1B, IL6
37	Tec Kinases Signaling36	10.0	BTK, MYD88, BMP6, CD4, IL10, IL13
38	NF-KappaB Family Pathway36	9.9	MYD88, BMP6, IRAK4, IL1A, IL1B, IL1R1
39	TGF-Beta Pathway36	9.9	BTK, BMP6, CD4, CDH1, IL10, IL12B
40	MAPK Family Pathway36	9.9	BTK, BMP6, CD4, IL10, IL12B, IL13
41	Chagas disease (American trypanosomiasis)20	9.8	PIK3R5, PIK3CG, MYD88, IRAK4, IL10, IL12B
42	Cytokine-cytokine receptor interaction20	9.7	VEGFA, CD40LG, IL10, IL12B, IL13, IL17A
43	Toxoplasmosis20	9.6	PIK3R5, PIK3CG, MYD88, LAMA2, LAMC2, CD40LG
44	JAK-STAT Pathway36	9.5	BTK, BMP6, CD4, IL10, IL12B, IL13
45	Measles20	9.4	PIK3R5, PIK3CG, MYD88, CD46, IRAK4, IL12B
46	p38 Signaling36	9.3	BTK, BMP6, CD4, IRAK4, IL10, IL12B
47	NF-KappaB (p50-p65) Pathway36	9.2	MYD88, BMP6, IRAK4, IL1A, IL1B, IL1R1
48	JNK Pathway36	9.2	BTK, BMP6, CD4, IL1R1, IL2, IL2RA
49	ERK Signaling36	9.1	BTK, BMP6, LAMA2, LAMC2, FN1, IL10
50	Molecular Mechanisms of Cancer36	9.0	PIK3CG, BTK, RB1, BMP6, LAMA2, CD4

Compounds related to meningitis according to GeneDecks:

(show top 50)    (show all 500)

id	Compound	Score	Top Affiliating Genes
1	atp32	12.2	PIK3C2A, NCAM1, BTK, RB1, VDAC1, MYD88
2	peptidoglycan32	11.9	VDAC1, MYD88, LBP, CD14, IL10, IL12B
3	oxygen32 18	12.6	PIK3C2A, RB1, SERPINA1, VDAC1, PARP1, CKB
4	fibrinogen32	11.6	PIK3C2A, BTK, SELE, SERPINA1, CHKB, LBP
5	leukotriene b432 42 18	13.5	SELL, PAFAH1B1, MPO, MMP9, FPR2, GUSB
6	superoxide32 18	12.4	PIK3C2A, RB1, SELL, CHKB, LBP, XDH
7	fmlp32	11.4	PIK3CG, SELL, VIM, MPO, CD14, CD47
8	nitric oxide32 9 18 9	14.3	NCAM1, RB1, SELE, SERPINA1, VDAC1, MYD88
9	cholesterol32 9 18 9	14.2	PIK3C2A, RB1, SELE, SERPINA1, CHKB, MUC1
10	thalidomide32 42 9 9	14.1	SELL, VEGFA, B2M, CD40LG, IL10, IL1B
11	nadph32 18	12.0	MYD88, FPR2, HTR2B, CYP20A1, KMO, G6PC
12	c2ceramide32	11.0	PIK3CG, PARP1, IL1B, CASP3, TNF, PTK2
13	cysteine32	11.0	PCNA, BTK, SERPINA1, VDAC1, PAFAH1B1, PARP1
14	2,5-oligoadenylate32	10.7	B2M, IL10, IL2, IL2RA, IL2RB, IL6
15	calcitriol32 42 9 18 9	14.7	RB1, BMP6, LBP, B2M, CFI, CD14
16	polyinosinic-polycytidylic acid32	10.7	SELE, LGALS9, IL10, IL12B, IL2, IL4
17	carbohydrates32	10.6	SELE, SELL, CFI, CEACAM5, CD14, CDH1
18	glycogen32 18	11.6	PIK3C2A, PIK3CG, VIM, VDAC1, CHKB, MUC1
19	gold32	10.6	PIK3C2A, VDAC1, MUC1, MUC16, LAMC2, CEACAM5
20	fluticasone propionate32 42 9 9	13.6	SELE, MPO, MMP9, IL13, IL16, IL1B
21	ribonucleic acid32	10.6	BMP6, MUC1, CEACAM5, FST, CD9, MMP2
22	doxycycline32 9 9	12.5	LACTB, CD79A, CD40LG, MMP2, MMP3, MMP8
23	citrate32	10.4	PIK3C2A, VDAC1, CHKB, CD79A, MKI67, GUSB
24	gnrh32	10.4	NCAM1, SELL, VIM, FST, MKI67, INHA
25	alpha tocopherol32	10.3	CHKB, SAA4, XDH, MMP9, GSR, IL13
26	agar32	10.3	RB1, VIM, VDAC1, MUC1, LACTB, CEACAM5
27	matrigel32	10.2	PIK3CG, NCAM1, RB1, SELE, VIM, VEGFA
28	pge232	10.1	SELE, VIP, FST, CD14, CD4, CDH1
29	creatinine32	10.1	NCAM1, PCNA, SELE, SELL, SERPINA1, VDAC1
30	erythromycin32 9 9	12.0	PIK3C2A, VIP, LACTB, MPO, CD40LG, MMP2
31	nifedipine32 9 9	12.0	PIK3CG, SELE, VIP, BMP6, B2M, MMP9
32	zidovudine32 9 9	11.9	B2M, CD4, CD9, GUSB, IL10, IL2
33	triptolide32	9.8	VEGFA, PARP1, CD14, MMP3, IL1B, IL2
34	parthenolide32	9.8	PIK3CG, MMP9, IL6, IL8, MAPK10, CCL2
35	choline32 9 18 9	12.5	PIK3C2A, VIM, VIP, CHKB, S100B, GRP
36	dopamine32 9 18 9	12.4	NCAM1, SELE, VIP, BMP6, CHKB, S100B
37	adriamycin32	9.4	RB1, VIM, MUC1, B2M, CEACAM5, CEACAM3
38	polysaccharide32	9.4	NCAM1, SELE, SELL, SERPINA1, VDAC1, BMP6
39	cytarabine32 34 9 9	12.3	PCNA, RB1, VIM, MUC1, MPO, MBP
40	thyroxine32 18	10.3	PIK3C2A, PCNA, VIP, CHKB, B2M, CFI
41	estradiol32 9 18 9	12.2	PCNA, RB1, VIM, CHKB, MUC1, CFI
42	mifepristone32 42 9 9	12.1	MUC1, MMP3, MKI67, IL1B, IL8, CCL2
43	bleomycin32 9 9	10.8	IL13, IL2RA, IL4, IL5, CCL2, CCL3
44	thapsigargin32 42	9.7	PIK3CG, PCNA, BTK, VIP, GRP, IL13
45	methotrexate32 34 42 9 9	12.4	PIK3C2A, PCNA, RB1, SELE, VIM, BMP6
46	geldanamycin32 9 9	10.2	PIK3CG, VEGFA, PARP1, CDH1, IL2RB, MAPK10
47	glutamine32	8.2	PIK3CG, NCAM1, PCNA, VIM, VIP, VDAC1
48	gemcitabine32 34 9 9	10.9	PCNA, VEGFA, PARP1, MUC1, MMP2, IL10
49	paraffin32	7.8	NCAM1, PCNA, RB1, SELL, SERPINA1, VIM
50	corticosterone32 18	INF	VIP, MPO, MIF, GRP, IL1A, IL1B

Cellular components related to meningitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.0	CR1, TNFSF10, TNFRSF13B, TNF, HLA-B, GJA1
2	external side of plasma membrane	GO:009897	10.9	ADA, SELL, NCAM1, B2M, CD79A, CD4
3	extracellular region	GO:005576	10.7	TGFB1, CASP1, F13A1, ALB, HTRA3, F5
4	cell surface	GO:009986	9.9	CR1, PLAU, TLR2, TIMP2, TGFB1, DPP4
5	extracellular space	GO:005615	9.5	AFP, HGF, TAC1, PVR, DPEP1, TGFB1
6	platelet alpha granule lumen	GO:031093	8.8	PPBP, EGF, TIMP1, TGFB1, HGF, F13A1
7	plasma membrane	GO:005886	8.5	AQP4, MOG, MPZ, MRGPRD, CEACAM7, CFB

Biological processes related to meningitis according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	11.9	C3AR1, CCL18, CCL24, CCL3, CCR8, CCL2
2	immune response	GO:006955	11.5	IL13, CD4, CFP, BMP6, C8B, C8A
3	complement activation, classical pathway	GO:006958	11.4	C8B, C8A, C5, C9, C6, CRP
4	innate immune response	GO:045087	11.4	NLRP3, CR1, HMGB1, CASP1, IFNB1, IFNA2
5	negative regulation of growth of symbiont in host	GO:044130	11.3	TIRAP, TLR2, TNF, IFNG, MBL2, IL12B
6	positive regulation of tumor necrosis factor production	GO:032760	11.3	LBP, CD14, IL12B, CCL3, IFNG, TLR2
7	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	11.2	GJA1, TNF, TNFSF10, LTBR, TLR4, TLR9
8	positive regulation of inflammatory response	GO:050729	11.2	WNT5A, PRKCA, TLR9, TLR4, TLR2, CCL24
9	positive regulation of interleukin-6 production	GO:032755	11.2	WNT5A, MYD88, LBP, IL1A, IL1B, IL6
10	defense response to Gram-positive bacterium	GO:050830	11.1	C5AR1, PGLYRP2, TIRAP, TLR2, TNF, MBL2
11	cell-cell signaling	GO:007267	11.0	CXCL5, CCL18, CCL24, CCL3, CCL4, CCL8
12	elevation of cytosolic calcium ion concentration	GO:007204	11.0	TAC1, CXCL13, CXCR3, C5AR1, C3AR1, TACR1
13	cellular response to interleukin-1	GO:071347	10.9	EDN1, ICAM1, CCL5, CCL3, CCL2, IL8
14	positive regulation of angiogenesis	GO:045766	10.9	C3AR1, C5, WNT5A, PRKCA, NOS3, CCL5
15	positive regulation of B cell proliferation	GO:030890	10.9	ADA, TIRAP, TLR4, TNFRSF13C, IL7, IL5
16	neutrophil chemotaxis	GO:030593	10.8	C5AR1, PRKCA, EDN1, IFNG, CCL3, CCL2
17	cellular response to lipopolysaccharide	GO:071222	10.8	ICAM1, TNFRSF1B, NOS2, TLR4, WNT5A, IFNG
18	inflammatory response	GO:006954	10.6	TACR1, TGFB1, TIRAP, TLR9, TLR2, NLRP3
19	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.6	TLR2, TLR4, TLR9, TIRAP, TGFB1, WNT5A
20	response to lipopolysaccharide	GO:032496	10.6	EDN1, TLR4, TIRAP, TAC1, CXCL10, LY96
21	positive regulation of chemokine biosynthetic process	GO:045080	10.5	WNT5A, TNF, IFNG, IL4, IL1B, MYD88
22	signal transduction	GO:007165	10.4	POMC, PGR, C5AR1, GDNF, CXCL5, CXCL13
23	lipopolysaccharide-mediated signaling pathway	GO:031663	10.3	LY96, TGFB1, TLR4, TLR2, NOS3, TNF
24	positive regulation of nitric oxide biosynthetic process	GO:045429	10.3	TLR4, TLR2, EGFR, EDN1, PTX3, TNF
25	cell adhesion	GO:007155	10.3	CCR8, F5, ICAM1, SRC, DPP4, PVR
26	cytokine-mediated signaling pathway	GO:019221	10.2	CCL2, IFNA2, IFNB1, IFNG, ICAM1, HLA-B
27	cellular response to interferon-gamma	GO:071346	10.2	WNT5A, NOS2, CCL5, CCL3, CCL2, AQP4
28	response to ethanol	GO:045471	10.2	TLR4, TACR1, PRF1, PRKCA, SOD1, NOS3
29	response to heat	GO:009408	10.2	SOD1, CXCL12, TACR1, NOS3, NOS1, PLA2G4A
30	cell surface receptor signaling pathway	GO:007166	10.0	IFNG, ERBB2, TNFRSF13B, EDN1, EGFR, TIRAP
31	anti-apoptosis	GO:006916	10.0	CCL2, TNF, NOS3, PROKR1, SOD1, HGF
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.9	HGF, RICTOR, CSPG4, TLR4, TP53, IGF2
33	response to hypoxia	GO:001666	9.8	SERPINA1, VEGFA, MMP9, IL1A, IL1B, MB
34	platelet degranulation	GO:002576	9.7	PPBP, EGF, TIMP1, TGFB1, SOD1, HGF
35	positive regulation of cell proliferation	GO:008284	9.1	TGFB1, TIMP1, EGFR, EGF, EDN1, DPP4
36	platelet activation	GO:030168	9.0	HGF, SOD1, PRKCA, TGFB1, ARRB2, FLNA
37	positive regulation of protein kinase B signaling cascade	GO:051897	8.8	TGFB1, EGFR, PTK2, TNF, IGF2, CCL3
38	positive regulation of MAP kinase activity	GO:043406	8.4	EDN1, EGF, EGFR, TGFB1, TNF, ERBB2
39	blood coagulation	GO:007596	7.3	NOS1, PLAU, PLA2G4A, PPBP, SRC, PTK2
40	negative regulation of apoptotic process	GO:043066	INF	TNF, PTEN, PTK2, EGFR, TIMP1, DPEP1
41	response to drug	GO:042493	INF	CASP1, TNF, CYP19A1, NOS3, COMT, EDN1
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	PKD1, NOS1, NTF3, SRF, TNF, TP53
43	negative regulation of cell proliferation	GO:008285	INF	PTEN, SRF, , NOS3, NF2, TIMP2

Molecular functions related to meningitis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.1	C5, IL8, CCL8, CCL4, CXCL5, CXCL2
2	cytokine activity	GO:005125	10.2	CSF2, CSF1, EDN1, LTB, TNFSF13B, TNFSF13
3	receptor binding	GO:005102	10.0	HLA-B, LBP, GJA1, CALCA, CAT, CCL2
4	protein homodimerization activity	GO:042803	9.6	CRP, PLOD1, NOS2, G6PD, TKT, TIRAP
5	growth factor activity	GO:008083	9.4	GDNF, HGF, CSF3, CSF2, CSF1, CXCL12
6	heparin binding	GO:008201	9.4	APP, CCL8, CCL2, CCL5, LTF, CXCL13
7	protein binding	GO:005515	INF	EPB41L3, HGF, E2F1, ADA, LY96, RICTOR