MCID: MNN013
MIFTS: 68

Meningitis malady

Neuronal diseases, Rare diseases, Infectious diseases, Respiratory diseases categories
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Summaries for Meningitis

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MedlinePlus:33 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. there are several types of meningitis. the most common is viral meningitis, which you get when a virus enters the body through the nose or mouth and travels to the brain. bacterial meningitis is rare, but can be deadly. it usually starts with bacteria that cause a cold-like infection. it can block blood vessels in the brain and lead to stroke and brain damage. it can also harm other organs. pneumococcal infections and meningococcal infections can cause bacterial meningitis. anyone can get meningitis, but it is more common in people whose bodies have trouble fighting infections. meningitis can progress rapidly. you should seek medical care quickly if you have a sudden fever a severe headache a stiff neck early treatment can help prevent serious problems, including death. vaccines can prevent some of the bacterial infections that cause meningitis. parents of adolescents and students living in college dorms should talk to a doctor about the vaccination. nih: national institute of neurological disorders and stroke

MalaCards based summary: Meningitis is related to meningococcal meningitis and aseptic meningitis. An important gene associated with Meningitis is ADA (adenosine deaminase), and among its related pathways are Oxidative Stress and Detoxification of Reactive Oxygen Species. The compounds bucillamine and muramyl dipeptide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Disease Ontology:8 Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. it can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. meningitis is a diffuse infection caused by a variety of different agents.

CDC:3 Meningitis is a disease caused by the inflammation of the protective membranes covering the brain and spinal cord known as the meninges. The inflammation is usually caused by an infection of the fluid surrounding the brain and spinal cord.

NINDS:43 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:65 Meningitis (from Greek ?????? m more...

Aliases & Classifications for Meningitis

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Related Diseases for Meningitis

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Diseases in the Viral Meningitis family:

Bacterial Meningitis Chronic Meningitis
meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 781)
idRelated DiseaseScoreTop Affiliating Genes
1meningococcal meningitis32.2CFP, MBL2
2aseptic meningitis32.0GUSB, SOD2, ADA
3viral meningitis31.8ADA, IL8, CRP
4encephalitis31.2TLR2, IL1B, CAT
5influenza31.1MBL2, ADA, SOD2
6bacterial meningitis31.0TLR2, CFP, GUSB, SOD2, ADA, IL8
7arthritis30.9IL8, IL1B
8osteomyelitis30.8CRP, CAT
9otitis media30.8TLR2, IL1B, MBL2
10bacteremia30.7MBL2, CRP, CAT, GUSB
11complement deficiency30.6MBL2, CFP
12hepatitis30.5CAT, SOD2, GUSB, TLR2
13herpes simplex30.5NTF3, SOD2, TLR2
14pneumonia30.5TLR2, IL10, IL8, IL1B, CRP, MBL2
15common variable immunodeficiency30.4IL10, MBL2
16malaria30.4TLR2, CFP, IL10
17behcet's disease30.4ADA, IL8, CRP, MBL2
18kawasaki disease30.4MMP9, CRP, MBL2
19neisseria meningitidis infection30.3TLR2, CFP, MBL2
20sarcoma30.3LYZ, ADA, SOD2, GUSB
21eosinophilia30.3MBL2, IL8, IL10
22aspergillosis30.3TLR2, MBL2
23chronic granulomatous disease30.3CFP, ADA, CAT
24rheumatic fever30.3MBL2, CRP
25peritonitis30.3TLR2, ADA, IL1B, CRP
26glomerulonephritis30.2CFP, IL1B, CAT, MBL2
27membranoproliferative glomerulonephritis30.2MBL2, CFP
28multiple sclerosis30.2MMP9, IL10, IL1B, MBL2
29lymphopenia30.2CAT, IL10, ADA
30familial mediterranean fever30.1IL1B, CRP
31lung adenocarcinoma30.1SOD2, MMP9, CAT
32sarcoidosis30.1IL1B, LYZ, ADA
33cerebral malaria30.1IL1B, IL10
34sepsis30.0TLR2, SOD2, IL10, IL8, IL1B, CRP
35tuberculosis30.0IL1B, CRP, MBL2, IL10, LYZ, TLR2
36systemic lupus erythematosus30.0CRP, IL10, ADA, GUSB, CFP, TLR2
37alcoholic liver cirrhosis30.0SOD2, IL8, CAT
38acute pancreatitis29.9IL10, IL8, CRP
39pancreatitis29.9SOD2, IL10, IL1B, CRP
40keratitis29.9MMP9, TLR2
41periodontal disease29.8GUSB, LYZ, CRP
42colitis29.8IL1B, IL8, IL10, TLR2
43mastitis29.8TLR2, LYZ, IL8, IL1B
44adenocarcinoma29.7GUSB, SOD2, MMP9, ADA, NTF3
45hyperglycemia29.7TLR2, SOD2, CAT, CRP
46adult respiratory distress syndrome29.7IL8, IL1B
47diabetes mellitus29.6CFP, SOD2, MMP9, IL1B, CAT, CRP
48periodontitis29.6TLR2, MMP9, IL8, IL1B
49leukemia29.5TLR2, GUSB, ADA, LYZ, NTF3, IL1B
50pulmonary tuberculosis29.5TLR2, GUSB, ADA, IL10, CAT, MBL2

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to meningitis

Symptoms for Meningitis

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Drugs & Therapeutics for Meningitis

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Drug clinical trials:

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Genetic Tests for Meningitis

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Anatomical Context for Meningitis

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MalaCards organs/tissues related to Meningitis:

32
Brain, Spinal cord, Testes, Bone, T cells, Pituitary, Neutrophil, Liver, B cells, Lung, Endothelial, Skin, Myeloid, Pineal, Cortex, Breast, Bone marrow, Eye, Prostate, Colon, Kidney, Monocytes, Medulla oblongata, Spleen, Heart, Thyroid, Adrenal gland, Cervix, Tonsil, Temporal lobe

Animal Models for Meningitis or affiliated genes

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MGI Mouse Phenotypes related to Meningitis:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4TLR2, GUSB, SOD2, MMP9, ADA, MBL2
2MP:00020068.1TLR2, SOD2, MMP9, IL10, IL1B, CAT
3MP:00028738.0TLR2, CFP, GUSB, ADA, NTF3, IL10
4MP:00053907.9TLR2, CFP, GUSB, MMP9, ADA, IL10
5MP:00053887.9TLR2, MMP9, ADA, NTF3, IL10
6MP:00053697.8IL10, NTF3, MMP9, SOD2, TLR2
7MP:00053847.7TLR2, GUSB, SOD2, MMP9, ADA, IL10
8MP:00053897.6GUSB, SOD2, MMP9, ADA, NTF3, IL10
9MP:00053977.3TLR2, GUSB, SOD2, MMP9, ADA, IL10
10MP:00053877.1MMP9, SOD2, CFP, TLR2, ADA, IL10
11MP:00053857.0TLR2, CFP, SOD2, MMP9, NTF3, IL10
12MP:00053786.9TLR2, GUSB, SOD2, MMP9, ADA, NTF3
13MP:00107686.4TLR2, CFP, GUSB, SOD2, MMP9, ADA
14MP:00053765.9MBL2, TLR2, CFP, GUSB, SOD2, MMP9

Publications for Meningitis

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Articles related to Meningitis:

(show top 50)    (show all 5009)
idTitleAuthorsYear
1
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. (24508198)
2014
2
Association of treatment for bacterial meningitis with the development of sequelae. (23537920)
2013
3
Aseptic meningitis. (23622323)
2013
4
Lumbar drainage for the treatment of severe bacterial meningitis. (23739926)
2013
5
The elusive diagnosis: recurrent benign lymphocytic meningitis. (24156176)
2013
6
Bacillus Calmette-GuAcrin is a preventive factor in mortality of childhood tuberculous meningitis. (24231588)
2013
7
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. (23445744)
2013
8
Cryptococcal meningitis occurring eight years before a diagnosis of lupus was made. (23973401)
2013
9
Recurrent case of ibuprofen-induced aseptic meningitis in mixed connective tissue disease. (23632618)
2013
10
Recurrent meningitis in children. (23894913)
2013
11
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
12
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
2013
13
Postoperative meningitis and epidural abscess due to extended-spectrum I^-lactamase-producing Klebsiella pneumoniae: a case report and a review of the literature. (22989843)
2012
14
Effect of vaccines on bacterial meningitis worldwide. (23141619)
2012
15
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
16
Etiology of aseptic meningitis, peripheral facial nerve palsy, and a combination of both in children. (19934789)
2010
17
Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis. (19681171)
2010
18
Rhabdoid meningioma presenting with subependymal and diffuse meningeal involvement but no mass lesion. (20800496)
2010
19
Shunting in hydrocephalus due to tuberculous meningitis. Cases presenting with high cerebrospinal fluid proteins in pediatric age. (19546843)
2009
20
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
21
Tuberculous meningitis presenting with unusual clinical features in Nigerians: Two case reports. (18816394)
2008
22
Bacterial meningitis score is valid in other populations of children. (18571557)
2008
23
Diagnosis of meningococcal meningitis in Brazil by use of PCR. (17366009)
2007
24
Endoscopic third ventriculostomy in prepontine-suprasellar tuberculoma with tuberculous meningitis hydrocephalus: a case report. (17190988)
2007
25
Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil. (17681359)
2007
26
Prophagic DNA fragments in Streptococcus agalactiae strains and association with neonatal meningitis. (16517893)
2006
27
Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. (16424233)
2006
28
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
29
The changing epidemiology of pediatric aseptic meningitis in Daejeon, Korea from 1987 to 2003. (16262909)
2005
30
Cytokine profile in cerebrospinal fluid of children with echovirus type 4 meningitis. (14643393)
2003
31
The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. (11792470)
2002
32
Streptococcal meningitis in adults: therapeutic outcomes and prognostic factors. (11532551)
2001
33
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
34
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
35
Nosocomial bacterial and fungal meningitis in cancer patients. (8564349)
1995
36
Pseudogout mimicking meningitis. (8461939)
1993
37
C-reactive proteins, immunoglobulin profile and mycobacterial antigens in cerebrospinal fluid of patients with pyogenic and tuberculous meningitis. (1293215)
1992
38
Group C streptococcal meningitis with favorable recovery. A case report. (2246567)
1990
39
Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. (2373990)
1990
40
Molecular epidemiology of neonatal meningitis due to Citrobacter diversus: a study of isolates from hospitals in Maryland. (3734491)
1986
41
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
42
Evaluation of aztreonam in experimental bacterial meningitis and cerebritis. (6362552)
1983
43
Intrafamilial meningococcal meningitis. (7428775)
1980
44
Meningococcal meningitis in northern Ghana: epidemiology and control measures. (889015)
1977
45
An unusual case of meningococcal meningitis. (5539776)
1971
46
Viral meningitis. (13525934)
1958
47
Purulent neonatal meningitis; a study of forty-five cases. (13406691)
1957
48
Meningococcal meningitis. (13296658)
1956
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Lateral Sinus Thrombosis; Serous Meningitis; Recovery. (19977139)
1913

Variations for Meningitis

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Expression for genes affiliated with Meningitis

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Expression patterns in normal tissues for genes affiliated with Meningitis

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Pathways for genes affiliated with Meningitis

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Pathways related to Meningitis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SOD2, CAT
2
Show member pathways
9.7CAT, SOD2
39.7CAT, SOD2
49.7MMP9, IL8
5
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6MBL2, CRP, CFP
69.5IL1B, IL10
79.5IL1B, IL10
89.5IL10, IL1B
99.4IL1B, IL8, TLR2
10
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4TLR2, IL8, IL1B
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.4TLR2, IL8, IL1B
129.4TLR2, IL8, IL1B
139.4TLR2, IL8, IL1B
149.3IL1B, IL8, IL10
159.3IL10, IL8, IL1B
169.3IL10, IL8, IL1B
179.3IL1B, IL8, MMP9
18
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.2SOD2, IL10, CAT
199.2IL1B, IL10, TLR2
20
Show member pathways
IL27-mediated signaling events37
9.2TLR2, IL10, IL1B
21
Show member pathways
9.2TLR2, IL10, IL1B
22
Show member pathways
9.1IL1B, IL8, CFP, TLR2
23
Show member pathways
thioredoxin pathway37
9.1SOD2, IL1B, CAT, CRP
248.9IL1B, IL8, IL10, TLR2
258.9IL1B, IL8, IL10, TLR2
26
Show member pathways
8.9IL1B, NTF3, TLR2
27
Show member pathways
8.8IL1B, IL8, IL10, SOD2
28
Show member pathways
8.5NTF3, IL10, IL8, IL1B
29
Show member pathways
8.5NTF3, IL10, IL8, IL1B
30
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.4TLR2, MMP9, IL10, IL8, IL1B
31
Show member pathways
8.1TLR2, NTF3, IL10, IL8, IL1B

Compounds for genes affiliated with Meningitis

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Compounds related to Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1bucillamine449.8IL1B, CRP, CAT
2muramyl dipeptide44 2810.6IL8, IL1B, TLR2
3echinacea449.6IL10, IL1B, IL8
4bifidobacterium449.6TLR2, GUSB, IL10
53-amino-1,2,4-triazole449.5CAT, SOD2, GUSB
6hbd2449.5IL1B, IL8, TLR2
7ulinastatin449.4IL8, IL10, GUSB
8etanercept44 50 1111.4IL10, CRP, IL1B, IL8
9diphenyleneiodonium449.3CAT, SOD2, IL8, IL1B
10gabexate mesilate449.3MMP9, IL10, CRP, IL8
11toxin-1449.3IL1B, IL8, IL10
12mip 1alpha449.3IL8, IL10, IL1B
13polyinosinic-polycytidylic acid449.3TLR2, IL8, IL10, IL1B
14il 10449.2IL10, IL1B, TLR2, IL8
15betacarotene449.1CRP, CAT, IL10, SOD2
16azithromycin44 1110.1CRP, IL8, IL10
17ribavirin44 50 1111.1ADA, MBL2, MMP9, IL10
188-isoprostane449.1IL10, CAT, MMP9, CRP, IL8
19polymyxin b449.0IL8, IL1B, IL10, MBL2, TLR2
20ivig449.0IL1B, IL10, MMP9, CRP
21lipoteichoic acid449.0IL10, TLR2, IL8, IL1B, MBL2
22peptidoglycan44 2810.0TLR2, IL10, IL8, IL1B, MBL2
23endotoxin449.0TLR2, IL10, IL1B, IL8, CRP
24leukotriene b444 61 2410.9GUSB, TLR2, IL1B, MMP9, IL8
25pdtc448.9SOD2, MMP9, IL8, CAT, IL1B
26simvastatin44 50 61 28 24 1113.9MMP9, TLR2, IL8, IL10, CRP
27neopterin448.9MBL2, ADA, IL1B, IL10, CRP, IL8
28curcumin448.9CAT, IL1B, SOD2, MMP9, IL8
29ccl344 289.8IL1B, IL8, IL10, MMP9, TLR2
304-hydroxynonenal44 249.8SOD2, IL10, GUSB, CAT
31cyclophosphamide44 50 1110.8MMP9, IL10, CRP, MBL2, SOD2
32n acetylcysteine448.7CAT, SOD2, MMP9, IL8, IL1B, CRP
33creatinine448.6GUSB, MBL2, CRP, SOD2, MMP9, ADA
34lactate448.5IL8, GUSB, CAT, ADA, MMP9, CRP
35methotrexate50 44 1110.5IL1B, IL10, ADA, MMP9, SOD2, CRP
36rantes448.4IL10, MMP9, TLR2, MBL2, IL1B, IL8
37cyclosporin a44 28 6110.4TLR2, SOD2, MMP9, IL10, ADA, IL8
38pge2448.3MMP9, GUSB, TLR2, IL1B, IL8, IL10
39sb 20358044 619.3IL1B, CAT, CRP, MMP9, IL10, TLR2
40genistein44 28 61 2 24 1113.0IL1B, NTF3, MMP9, SOD2, GUSB, IL8
41histamine44 28 249.9IL1B, IL8, GUSB, IL10, ADA, TLR2
42dexamethasone44 50 28 1110.8MMP9, SOD2, TLR2, ADA, IL10, IL1B
43actinomycin d447.8CAT, IL1B, IL8, NTF3, MMP9, SOD2
44ly294002447.6MMP9, SOD2, NTF3, CRP, IL1B, IL8
45aspartate447.4ADA, NTF3, IL10, MMP9, SOD2, GUSB
46nitric oxide44 24 119.4IL10, IL8, MBL2, CAT, IL1B, TLR2
47superoxide44 248.3CAT, IL1B, IL8, NTF3, SOD2, GUSB
48cysteine447.3MBL2, TLR2, CAT, SOD2, MMP9, NTF3
49cycloheximide447.0TLR2, SOD2, NTF3, IL10, IL1B, CAT
50vegf446.7MBL2, TLR2, SOD2, MMP9, ADA, NTF3

GO Terms for genes affiliated with Meningitis

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Cellular components related to Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.0MMP9, LYZ, NTF3, IL8, IL1B, CRP
2extracellular spaceGO:0056156.7MBL2, CFP, MMP9, ADA, LYZ, IL10

Biological processes related to Meningitis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin EGO:03319710.2CAT, ADA
2opsonizationGO:00822810.2CRP, MBL2
3embryonic digestive tract developmentGO:04856610.1IL8, ADA
4response to molecule of bacterial originGO:00223710.0IL8, IL10
5response to hyperoxiaGO:05509310.0CAT, SOD2
6defense response to Gram-positive bacteriumGO:0508309.8MBL2, CRP, TLR2
7positive regulation of NF-kappaB import into nucleusGO:0423469.8TLR2, IL1B
8negative regulation of interleukin-12 productionGO:0326959.8IL10, TLR2
9positive regulation of interleukin-8 productionGO:0327579.8IL1B, TLR2
10lipopolysaccharide-mediated signaling pathwayGO:0316639.7IL1B, TLR2
11positive regulation of cytokine secretionGO:0507159.6IL10, TLR2
12positive regulation of NF-kappaB transcription factor activityGO:0510929.6TLR2, IL1B, CAT
13negative regulation of growth of symbiont in hostGO:0441309.6MBL2, IL10, TLR2
14induction of positive chemotaxisGO:0509309.6IL8, NTF3
15positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, SOD2, TLR2
16embryo implantationGO:0075669.5IL1B, MMP9
17immune responseGO:0069559.4IL1B, IL8, CFP, TLR2
18response to activityGO:0148239.4SOD2, IL10
19negative regulation of cell proliferationGO:0082859.2TLR2, SOD2, IL8, IL1B
20response to hypoxiaGO:0016669.2TLR2, SOD2, ADA, CAT, CRP
21defense response to bacteriumGO:0427429.0CFP, LYZ, IL10, MBL2
22cell-cell signalingGO:0072678.4IL1B, IL10, NTF3
23inflammatory responseGO:0069548.4CRP, IL1B, IL8, IL10, LYZ, TLR2

Products for genes affiliated with Meningitis

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Sources for Meningitis

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
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40NDF-RT
43NINDS
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