MCID: MNN013
MIFTS: 58

Meningitis malady

Neuronal diseases, Rare diseases, Infectious diseases categories

Aliases & Classifications for Meningitis

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Sources:
9Disease Ontology, 42NINDS, 11DISEASES, 43Novoseek, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 25ICD10
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Summaries for Meningitis

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MedlinePlus:32 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. there are several types of meningitis. the most common is viral meningitis, which you get when a virus enters the body through the nose or mouth and travels to the brain. bacterial meningitis is rare, but can be deadly. it usually starts with bacteria that cause a cold-like infection. it can block blood vessels in the brain and lead to stroke and brain damage. it can also harm other organs. pneumococcal infections and meningococcal infections can cause bacterial meningitis. anyone can get meningitis, but it is more common in people whose bodies have trouble fighting infections. meningitis can progress rapidly. you should seek medical care quickly if you have a sudden fever a severe headache a stiff neck early treatment can help prevent serious problems, including death. vaccines can prevent some of the bacterial infections that cause meningitis. parents of adolescents and students living in college dorms should talk to a doctor about the vaccination. nih: national institute of neurological disorders and stroke

MalaCards based summary: Meningitis is related to meningococcal meningitis and aseptic meningitis. An important gene associated with Meningitis is ADA (adenosine deaminase), and among its related pathways are Oxidative Stress and Detoxification of Reactive Oxygen Species. The compounds bucillamine and muramyl dipeptide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Disease Ontology:9 Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. it can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. meningitis is a diffuse infection caused by a variety of different agents.

CDC:3 Meningitis is a disease caused by the inflammation of the protective membranes covering the brain and spinal cord known as the meninges. The inflammation is usually caused by an infection of the fluid surrounding the brain and spinal cord.

NINDS:42 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

Wikipedia:63 Meningitis (from Greek ?????? m more...

Related Diseases for Meningitis

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Diseases in the Meningitis family:

Bacterial Meningitis Chronic Meningitis
Viral Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 765)
idRelated DiseaseScoreTop Affiliating Genes
1meningococcal meningitis32.2CFP, MBL2
2aseptic meningitis32.0GUSB, SOD2, ADA
3viral meningitis31.8ADA, IL8, CRP
4encephalitis31.2TLR2, IL1B, CAT
5influenza31.1MBL2, ADA, SOD2
6bacterial meningitis31.0TLR2, CFP, GUSB, SOD2, ADA, IL8
7arthritis30.9IL8, IL1B
8osteomyelitis30.8CRP, CAT
9otitis media30.8TLR2, IL1B, MBL2
10bacteremia30.7MBL2, CRP, CAT, GUSB
11complement deficiency30.6MBL2, CFP
12chronic granulomatous disease30.6CFP, ADA, CAT
13familial mediterranean fever, ar30.6IL1B, CRP
14hepatitis30.5CAT, SOD2, GUSB, TLR2
15herpes simplex30.5NTF3, SOD2, TLR2
16pneumonia30.5TLR2, IL10, IL8, IL1B, CRP, MBL2
17behcet's disease30.4ADA, IL8, CRP, MBL2
18common variable immunodeficiency30.4IL10, MBL2
19kawasaki disease30.4MMP9, CRP, MBL2
20malaria30.4IL1B, IL10
21sarcoma30.3LYZ, ADA, SOD2, GUSB
22eosinophilia30.3MBL2, IL8, IL10
23aspergillosis30.3TLR2, MBL2
24rheumatic fever30.2MBL2, CRP
25peritonitis30.2TLR2, ADA, IL1B, CRP
26glomerulonephritis30.2CFP, IL1B, CAT, MBL2
27neisseria meningitidis infection30.2TLR2, CFP, MBL2
28membranoproliferative glomerulonephritis30.2MBL2, CFP
29lymphopenia30.1CAT, IL10, ADA
30acute pancreatitis30.1IL10, IL8, CRP
31severe combined immunodeficiency, x-linked30.1CFP, ADA
32pancreatitis30.0SOD2, IL10, IL1B, CRP
33systemic lupus erythematosus30.0CRP, IL10, ADA, GUSB, CFP, TLR2
34tuberculosis30.0IL1B, CRP, MBL2, IL10, LYZ, TLR2
35alcoholic liver cirrhosis30.0SOD2, IL8, CAT
36keratitis29.9MMP9, TLR2
37periodontal disease29.8GUSB, LYZ, CRP
38colitis29.8IL1B, IL8, IL10, TLR2
39mastitis29.8TLR2, LYZ, IL8, IL1B
40adenocarcinoma29.7GUSB, SOD2, MMP9, ADA, NTF3
41hyperglycemia29.7TLR2, SOD2, CAT, CRP
42brain disease29.7CAT, IL1B, NTF3, SOD2
43hepatitis b29.7TLR2, IL10, CAT, MBL2
44periodontitis29.6TLR2, MMP9, IL8, IL1B
45leukemia29.5TLR2, GUSB, ADA, LYZ, NTF3, IL1B
46pulmonary tuberculosis29.5TLR2, GUSB, ADA, IL10, CAT, MBL2
47hepatitis c29.5TLR2, SOD2, IL10
48ulcerative colitis29.4TLR2, GUSB, IL10, IL8, IL1B, CRP
49viral infectious disease29.4TLR2, GUSB, IL10, IL8, IL1B, MBL2
50liver disease29.4CRP, CAT, IL1B, IL10, SOD2

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to meningitis

Symptoms for Meningitis

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Drugs & Therapeutics for Meningitis

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Drug clinical trials:

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Genetic Tests for Meningitis

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Anatomical Context for Meningitis

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MalaCards organs/tissues related to Meningitis:

31
Brain, Spinal cord, Testes, Bone, T cells, Pituitary, Neutrophil, Liver, B cells, Lung, Endothelial, Skin, Myeloid, Pineal, Cortex, Breast, Bone marrow, Eye, Prostate, Colon, Kidney, Monocytes, Temporal lobe, Medulla oblongata, Spleen, Heart, Thyroid, Adrenal gland, Cervix, Tonsil

Animal Models for Meningitis or affiliated genes

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MGI Mouse Phenotypes related to Meningitis:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4TLR2, GUSB, SOD2, MMP9, ADA, MBL2
2MP:00020068.1TLR2, SOD2, MMP9, IL10, IL1B, CAT
3MP:00028738.0TLR2, CFP, GUSB, ADA, NTF3, IL10
4MP:00053907.9TLR2, CFP, GUSB, MMP9, ADA, IL10
5MP:00053887.9TLR2, MMP9, ADA, NTF3, IL10
6MP:00053697.8IL10, NTF3, MMP9, SOD2, TLR2
7MP:00053847.7TLR2, GUSB, SOD2, MMP9, ADA, IL10
8MP:00053897.6GUSB, SOD2, MMP9, ADA, NTF3, IL10
9MP:00053977.3TLR2, GUSB, SOD2, MMP9, ADA, IL10
10MP:00053877.1MMP9, SOD2, CFP, TLR2, ADA, IL10
11MP:00053857.0TLR2, CFP, SOD2, MMP9, NTF3, IL10
12MP:00053786.9TLR2, GUSB, SOD2, MMP9, ADA, NTF3
13MP:00107686.4TLR2, CFP, GUSB, SOD2, MMP9, ADA
14MP:00053765.9MBL2, TLR2, CFP, GUSB, SOD2, MMP9

Publications for Meningitis

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Articles related to Meningitis:

(show top 50)    (show all 5135)
idTitleAuthorsYear
1
Chickenpox complicated by pneumococcal meningitis: A rare coinfection. (25282451)
2014
2
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. (24508198)
2014
3
Association of treatment for bacterial meningitis with the development of sequelae. (23537920)
2013
4
Aseptic meningitis. (23622323)
2013
5
Lumbar drainage for the treatment of severe bacterial meningitis. (23739926)
2013
6
The elusive diagnosis: recurrent benign lymphocytic meningitis. (24156176)
2013
7
Bacillus Calmette-GuAcrin is a preventive factor in mortality of childhood tuberculous meningitis. (24231588)
2013
8
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. (23445744)
2013
9
Cryptococcal meningitis occurring eight years before a diagnosis of lupus was made. (23973401)
2013
10
Recurrent case of ibuprofen-induced aseptic meningitis in mixed connective tissue disease. (23632618)
2013
11
Recurrent meningitis in children. (23894913)
2013
12
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
13
Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse. (23951382)
2013
14
Postoperative meningitis and epidural abscess due to extended-spectrum I^-lactamase-producing Klebsiella pneumoniae: a case report and a review of the literature. (22989843)
2012
15
Effect of vaccines on bacterial meningitis worldwide. (23141619)
2012
16
Treatment of Drug-resistant Pneumococcal Meningitis. (21308542)
2010
17
Etiology of aseptic meningitis, peripheral facial nerve palsy, and a combination of both in children. (19934789)
2010
18
Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis. (19681171)
2010
19
Rhabdoid meningioma presenting with subependymal and diffuse meningeal involvement but no mass lesion. (20800496)
2010
20
Shunting in hydrocephalus due to tuberculous meningitis. Cases presenting with high cerebrospinal fluid proteins in pediatric age. (19546843)
2009
21
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
22
Tuberculous meningitis presenting with unusual clinical features in Nigerians: Two case reports. (18816394)
2008
23
Bacterial meningitis score is valid in other populations of children. (18571557)
2008
24
Diagnosis of meningococcal meningitis in Brazil by use of PCR. (17366009)
2007
25
Endoscopic third ventriculostomy in prepontine-suprasellar tuberculoma with tuberculous meningitis hydrocephalus: a case report. (17190988)
2007
26
Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil. (17681359)
2007
27
Prophagic DNA fragments in Streptococcus agalactiae strains and association with neonatal meningitis. (16517893)
2006
28
Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. (16424233)
2006
29
Pneumococcal meningitis epidemics in Africa. (16912942)
2006
30
The changing epidemiology of pediatric aseptic meningitis in Daejeon, Korea from 1987 to 2003. (16262909)
2005
31
Cytokine profile in cerebrospinal fluid of children with echovirus type 4 meningitis. (14643393)
2003
32
The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. (11792470)
2002
33
Streptococcal meningitis in adults: therapeutic outcomes and prognostic factors. (11532551)
2001
34
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
35
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis. (9083551)
1997
36
Nosocomial bacterial and fungal meningitis in cancer patients. (8564349)
1995
37
Pseudogout mimicking meningitis. (8461939)
1993
38
C-reactive proteins, immunoglobulin profile and mycobacterial antigens in cerebrospinal fluid of patients with pyogenic and tuberculous meningitis. (1293215)
1992
39
Group C streptococcal meningitis with favorable recovery. A case report. (2246567)
1990
40
Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. (2373990)
1990
41
Molecular epidemiology of neonatal meningitis due to Citrobacter diversus: a study of isolates from hospitals in Maryland. (3734491)
1986
42
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
43
Evaluation of aztreonam in experimental bacterial meningitis and cerebritis. (6362552)
1983
44
Intrafamilial meningococcal meningitis. (7428775)
1980
45
An unusual case of meningococcal meningitis. (5539776)
1971
46
Viral meningitis. (13525934)
1958
47
Purulent neonatal meningitis; a study of forty-five cases. (13406691)
1957
48
Meningococcal meningitis. (13296658)
1956
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Lateral Sinus Thrombosis; Serous Meningitis; Recovery. (19977139)
1913

Variations for Meningitis

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Expression for genes affiliated with Meningitis

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Search GEO for disease gene expression data for Meningitis.

Pathways for genes affiliated with Meningitis

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Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SOD2, CAT
2
Show member pathways
9.7CAT, SOD2
39.7CAT, SOD2
49.7MMP9, IL8
5
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.6MBL2, CRP, CFP
69.5IL1B, IL10
79.5IL1B, IL10
89.5IL10, IL1B
99.4IL1B, IL8, TLR2
10
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4TLR2, IL8, IL1B
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.4TLR2, IL8, IL1B
129.4TLR2, IL8, IL1B
139.3IL1B, IL8, IL10
149.3IL10, IL8, IL1B
159.3IL10, IL8, IL1B
169.3IL1B, IL8, MMP9
17
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.2SOD2, IL10, CAT
189.2IL1B, IL10, TLR2
19
Show member pathways
IL27-mediated signaling events36
9.2TLR2, IL10, IL1B
20
Show member pathways
9.2TLR2, IL10, IL1B
21
Show member pathways
9.1IL1B, IL8, CFP, TLR2
22
Show member pathways
thioredoxin pathway36
9.1SOD2, IL1B, CAT, CRP
238.9IL1B, IL8, IL10, TLR2
248.9IL1B, IL8, IL10, TLR2
25
Show member pathways
8.9IL1B, NTF3, TLR2
26
Show member pathways
8.8IL1B, IL8, IL10, SOD2
27
Show member pathways
8.5NTF3, IL10, IL8, IL1B
28
Show member pathways
8.5NTF3, IL10, IL8, IL1B
29
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.4TLR2, MMP9, IL10, IL8, IL1B
30
Show member pathways
8.1TLR2, NTF3, IL10, IL8, IL1B

Compounds for genes affiliated with Meningitis

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Compounds related to Meningitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1bucillamine439.8IL1B, CRP, CAT
2muramyl dipeptide43 2810.6IL8, IL1B, TLR2
3echinacea439.6IL10, IL1B, IL8
4bifidobacterium439.6TLR2, GUSB, IL10
53-amino-1,2,4-triazole439.5CAT, SOD2, GUSB
6hbd2439.5IL1B, IL8, TLR2
7ulinastatin439.4IL8, IL10, GUSB
8etanercept43 49 1211.4IL10, CRP, IL1B, IL8
9diphenyleneiodonium439.3CAT, SOD2, IL8, IL1B
10gabexate mesilate439.3MMP9, IL10, CRP, IL8
11toxin-1439.3IL1B, IL8, IL10
12mip 1alpha439.3IL8, IL10, IL1B
13polyinosinic-polycytidylic acid439.3TLR2, IL8, IL10, IL1B
14il 10439.2IL10, IL1B, TLR2, IL8
15betacarotene439.1CRP, CAT, IL10, SOD2
16azithromycin43 1210.1CRP, IL8, IL10
17ribavirin43 49 1211.1ADA, MBL2, MMP9, IL10
188-isoprostane439.1IL10, CAT, MMP9, CRP, IL8
19polymyxin b439.0IL8, IL1B, IL10, MBL2, TLR2
20ivig439.0IL1B, IL10, MMP9, CRP
21lipoteichoic acid439.0IL10, TLR2, IL8, IL1B, MBL2
22peptidoglycan43 2810.0TLR2, IL10, IL8, IL1B, MBL2
23endotoxin439.0TLR2, IL10, IL1B, IL8, CRP
24leukotriene b443 59 2410.9GUSB, TLR2, IL1B, MMP9, IL8
25pdtc438.9SOD2, MMP9, IL8, CAT, IL1B
26simvastatin43 49 59 28 24 1213.9MMP9, TLR2, IL8, IL10, CRP
27neopterin438.9MBL2, ADA, IL1B, IL10, CRP, IL8
28curcumin438.9CAT, IL1B, SOD2, MMP9, IL8
29ccl343 289.8IL1B, IL8, IL10, MMP9, TLR2
304-hydroxynonenal43 249.8SOD2, IL10, GUSB, CAT
31cyclophosphamide43 49 1210.8MMP9, IL10, CRP, MBL2, SOD2
32n acetylcysteine438.7CAT, SOD2, MMP9, IL8, IL1B, CRP
33creatinine438.6GUSB, MBL2, CRP, SOD2, MMP9, ADA
34lactate438.5IL8, GUSB, CAT, ADA, MMP9, CRP
35methotrexate49 43 1210.5IL1B, IL10, ADA, MMP9, SOD2, CRP
36rantes438.4IL10, MMP9, TLR2, MBL2, IL1B, IL8
37cyclosporin a43 28 5910.4TLR2, SOD2, MMP9, IL10, ADA, IL8
38pge2438.3MMP9, GUSB, TLR2, IL1B, IL8, IL10
39sb 20358043 599.3IL1B, CAT, CRP, MMP9, IL10, TLR2
40genistein43 28 59 2 24 1213.0IL1B, NTF3, MMP9, SOD2, GUSB, IL8
41histamine43 28 249.9IL1B, IL8, GUSB, IL10, ADA, TLR2
42dexamethasone43 49 28 1210.8MMP9, SOD2, TLR2, ADA, IL10, IL1B
43actinomycin d437.8CAT, IL1B, IL8, NTF3, MMP9, SOD2
44ly294002437.6MMP9, SOD2, NTF3, CRP, IL1B, IL8
45aspartate437.4ADA, NTF3, IL10, MMP9, SOD2, GUSB
46nitric oxide43 24 129.4IL10, IL8, MBL2, CAT, IL1B, TLR2
47superoxide43 248.3CAT, IL1B, IL8, NTF3, SOD2, GUSB
48cysteine437.3MBL2, TLR2, CAT, SOD2, MMP9, NTF3
49cycloheximide437.0TLR2, SOD2, NTF3, IL10, IL1B, CAT
50vegf436.7MBL2, TLR2, SOD2, MMP9, ADA, NTF3

GO Terms for genes affiliated with Meningitis

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Cellular components related to Meningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.0MMP9, LYZ, NTF3, IL8, IL1B, CRP
2extracellular spaceGO:00056156.7MBL2, CFP, MMP9, ADA, LYZ, IL10

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin EGO:003319710.2CAT, ADA
2opsonizationGO:000822810.2CRP, MBL2
3embryonic digestive tract developmentGO:004856610.1IL8, ADA
4response to molecule of bacterial originGO:000223710.0IL8, IL10
5response to hyperoxiaGO:005509310.0CAT, SOD2
6defense response to Gram-positive bacteriumGO:00508309.8MBL2, CRP, TLR2
7positive regulation of NF-kappaB import into nucleusGO:00423469.8TLR2, IL1B
8negative regulation of interleukin-12 productionGO:00326959.8IL10, TLR2
9positive regulation of interleukin-8 productionGO:00327579.8IL1B, TLR2
10lipopolysaccharide-mediated signaling pathwayGO:00316639.7IL1B, TLR2
11positive regulation of cytokine secretionGO:00507159.6IL10, TLR2
12positive regulation of NF-kappaB transcription factor activityGO:00510929.6TLR2, IL1B, CAT
13negative regulation of growth of symbiont in hostGO:00441309.6MBL2, IL10, TLR2
14induction of positive chemotaxisGO:00509309.6IL8, NTF3
15positive regulation of nitric oxide biosynthetic processGO:00454299.6IL1B, SOD2, TLR2
16embryo implantationGO:00075669.5IL1B, MMP9
17immune responseGO:00069559.4IL1B, IL8, CFP, TLR2
18response to activityGO:00148239.4SOD2, IL10
19negative regulation of cell proliferationGO:00082859.2TLR2, SOD2, IL8, IL1B
20response to hypoxiaGO:00016669.2TLR2, SOD2, ADA, CAT, CRP
21defense response to bacteriumGO:00427429.0CFP, LYZ, IL10, MBL2
22cell-cell signalingGO:00072678.4IL1B, IL10, NTF3
23inflammatory responseGO:00069548.4CRP, IL1B, IL8, IL10, LYZ, TLR2

Products for genes affiliated with Meningitis

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Sources for Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet