MCID: MNN024
MIFTS: 26

Meningitis and Encephalitis

Aliases & Classifications for Meningitis and Encephalitis

MalaCards integrated aliases for Meningitis and Encephalitis:

Name: Meningitis and Encephalitis 50

Summaries for Meningitis and Encephalitis

NINDS : 50 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone can get encephalitis or meningitis.Inflammation from encephalitis and meningitis produce a wide range of symptoms.  Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Symptoms of meningitis, which may appear suddenly, often include high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, and vomiting. Changes in behavior such as confusion, sleepiness, and difficulty waking up may also occur. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head). Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately.

MalaCards based summary : Meningitis and Encephalitis is related to meningoencephalitis and encephalitis. An important gene associated with Meningitis and Encephalitis is ALB (Albumin), and among its related pathways/superpathways are Longevity regulating pathway and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cellular and neoplasm

Related Diseases for Meningitis and Encephalitis

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to Meningitis and Encephalitis

Symptoms & Phenotypes for Meningitis and Encephalitis

MGI Mouse Phenotypes related to Meningitis and Encephalitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.26 ALB CAT CP SOD1
2 neoplasm MP:0002006 8.8 ALB CAT SOD1

Drugs & Therapeutics for Meningitis and Encephalitis

Search Clinical Trials , NIH Clinical Center for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

Anatomical Context for Meningitis and Encephalitis

MalaCards organs/tissues related to Meningitis and Encephalitis:

38
Brain, Spinal Cord, Testes, B Cells

Publications for Meningitis and Encephalitis

Articles related to Meningitis and Encephalitis:

(show all 27)
# Title Authors Year
1
Evaluation of a Commercial Multiplex Molecular Panel For the Diagnosis of Infectious Meningitis and Encephalitis. ( 29436421 )
2018
2
Meningitis and encephalitis in Poland in 2015 ( 29415527 )
2017
3
Outcome of Patients with Meningitis and Encephalitis at Tertiary Care Hospital in Eastern Nepal. ( 29446361 )
2017
4
Emergency Neurologic Life Support: Meningitis and Encephalitis. ( 28916998 )
2017
5
Infectious Meningitis and Encephalitis. ( 27643906 )
2016
6
Viral meningitis and encephalitis. ( 23981453 )
2013
7
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. ( 22123531 )
2012
8
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. ( 23235298 )
2012
9
Establishing surveillance for acute meningitis and encephalitis syndromes through expansion of poliomyelitis and measles surveillance networks in Bangladesh,China and India, 2006a892008. ( 23311008 )
2012
10
Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab. ( 21622521 )
2011
11
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
12
Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. ( 18637823 )
2008
13
Etiology of aseptic meningitis and encephalitis in an adult population. ( 16401850 )
2006
14
Evaluation of antioxidant status in children with acute bacterial meningitis and encephalitis. ( 14585750 )
2003
15
Viral meningitis and encephalitis: traditional and emerging viral agents. ( 12881794 )
2003
16
Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis. ( 11018820 )
2000
17
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9705409 )
1998
18
[Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. ( 9424322 )
1997
19
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. ( 9041414 )
1997
20
Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9504768 )
1997
21
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. ( 8890768 )
1996
22
Viral meningitis and encephalitis. ( 1455104 )
1992
23
Viral meningitis and encephalitis in Saudi Arabia. ( 2585577 )
1989
24
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. ( 3135367 )
1988
25
Mumps virus meningitis and encephalitis without parotitis. ( 750438 )
1978
26
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. ( 5410113 )
1970
27
Acute serous meningitis and encephalitis complicating scarlet fever. ( 18118945 )
1949

Variations for Meningitis and Encephalitis

Expression for Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for Meningitis and Encephalitis

GO Terms for Meningitis and Encephalitis

Cellular components related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 ALB CAT CP SOD1
2 extracellular region GO:0005576 9.46 ALB CAT CP SOD1
3 blood microparticle GO:0072562 9.4 ALB CP
4 myelin sheath GO:0043209 9.37 ALB SOD1
5 peroxisome GO:0005777 9.26 CAT SOD1
6 mitochondrial intermembrane space GO:0005758 8.96 CAT SOD1
7 extracellular space GO:0005615 8.92 ALB CAT CP SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.61 CAT CP SOD1
2 cellular protein metabolic process GO:0044267 9.52 ALB CP
3 aging GO:0007568 9.51 CAT SOD1
4 negative regulation of apoptotic process GO:0043066 9.5 ALB CAT SOD1
5 response to oxidative stress GO:0006979 9.49 CAT SOD1
6 platelet degranulation GO:0002576 9.48 ALB SOD1
7 response to ethanol GO:0045471 9.46 CAT SOD1
8 cellular response to oxidative stress GO:0034599 9.4 CAT SOD1
9 cellular oxidant detoxification GO:0098869 9.37 ALB CAT
10 cellular iron ion homeostasis GO:0006879 9.26 CP SOD1
11 response to hydrogen peroxide GO:0042542 9.16 CAT SOD1
12 retina homeostasis GO:0001895 8.96 ALB SOD1
13 response to reactive oxygen species GO:0000302 8.62 CAT SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 CAT CP SOD1
2 chaperone binding GO:0051087 9.33 ALB CP SOD1
3 copper ion binding GO:0005507 9.13 ALB CP SOD1
4 antioxidant activity GO:0016209 8.8 ALB CAT SOD1

Sources for Meningitis and Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....