MCID: MNN024
MIFTS: 31

Meningitis and Encephalitis malady

Summaries for Meningitis and Encephalitis

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45NINDS, 34MalaCards
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NINDS:45 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

MalaCards: Meningitis and Encephalitis is related to meningitis and encephalitis. An important gene associated with Meningitis and Encephalitis is CAT (catalase), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and Peroxisome. The compounds u 83836e and fpl 55712 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes.

Aliases & Classifications for Meningitis and Encephalitis

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45NINDS
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Aliases & Descriptions:

meningitis and encephalitis 45


Related Diseases for Meningitis and Encephalitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Meningitis and Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.1CRP, CAT
2encephalitis10.8
3viral meningitis10.5
4aseptic meningitis10.5
5measles10.3
6poliomyelitis10.3
7relapsing polychondritis10.1
8meningoencephalitis10.1
9parotitis10.1
10scarlet fever10.1
11mumps10.1
12cerebritis10.1
13bacterial meningitis10.1
14herpes simplex10.1
15herpes simplex encephalitis10.1
16west nile virus10.1
17hypermethioninemia10.1SOD1
18diabetic cataract10.1CAT
19gastritis10.1CAT
20bacteriuria10.1CRP
21systemic lupus erythematosus10.0CRP
22vascular disease10.0CAT
23pneumoconiosis10.0SOD1, CAT
24senile cataract10.0CAT, SOD1
25wilson disease10.0CAT, SOD1
26alcoholic liver cirrhosis10.0CAT, SOD1
27chronic granulomatous disease10.0SOD1, CAT
28male infertility10.0CAT, SOD1
29vitiligo10.0SOD1, CAT
30cataract10.0SOD1, CAT
31tonsillitis10.0SOD1, CRP
32hyperhomocysteinemia10.0SOD1, CRP
33uremia10.0CRP, SOD1
34bacteremia10.0CRP, CAT
35acute pancreatitis10.0SOD1, CRP
36osteomyelitis10.0CAT, CRP
37cork-handlers' disease10.0SOD1, CAT
38pancreatitis10.0SOD1, CRP
39eye disease10.0CRP, CAT
40tuberculosis10.0CRP
41parkinson's disease10.0CAT, SOD1
42primary hyperoxaluria10.0CRP, CAT
43coronary artery disease10.0SOD1, CRP
44galactosemia10.0CRP, CAT
45pre-eclampsia10.0CAT, SOD1
46congenital heart disease10.0CAT, CRP
47acute myocardial infarction10.0CAT, CRP
48hyperglycemia9.9SOD1, CAT, CRP
49chronic kidney failure9.9SOD1, CRP, CAT
50type 2 diabetes mellitus9.9SOD1, CAT, CRP

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to meningitis and encephalitis

Symptoms for Meningitis and Encephalitis

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Drugs & Therapeutics for Meningitis and Encephalitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Meningitis and Encephalitis

Drug clinical trials:

Search ClinicalTrials for Meningitis and Encephalitis

Search NIH Clinical Center for Meningitis and Encephalitis

Search CenterWatch for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

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Anatomical Context for Meningitis and Encephalitis

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34MalaCards
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MalaCards organs/tissues related to Meningitis and Encephalitis:

34
Brain, Spinal cord, Testes, B cells

Animal Models for Meningitis and Encephalitis or affiliated genes

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Publications for Meningitis and Encephalitis

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53PubMed
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Articles related to Meningitis and Encephalitis:

(show all 21)
idTitleAuthorsYear
1
Viral meningitis and encephalitis. (23981453)
2013
2
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. (23235298)
2012
3
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. (22123531)
2012
4
Establishing surveillance for acute meningitis and encephalitis syndromes through expansion of poliomyelitis and measles surveillance networks in Bangladesh,China and India, 2006a892008. (23311008)
2012
5
Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab. (21622521)
2011
6
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. (21292281)
2011
7
Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. (18637823)
2008
8
Etiology of aseptic meningitis and encephalitis in an adult population. (16401850)
2006
9
Evaluation of antioxidant status in children with acute bacterial meningitis and encephalitis. (14585750)
2003
10
Viral meningitis and encephalitis: traditional and emerging viral agents. (12881794)
2003
11
Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis. (11018820)
2000
12
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
13
Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis. (9504768)
1997
14
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. (9041414)
1997
15
Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. (9424322)
1997
16
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. (8890768)
1996
17
Viral meningitis and encephalitis. (1455104)
1992
18
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. (3135367)
1988
19
Mumps virus meningitis and encephalitis without parotitis. (750438)
1978
20
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. (5410113)
1970
21
Acute serous meningitis and encephalitis complicating scarlet fever. (18118945)
1949

Variations for Meningitis and Encephalitis

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Expression for genes affiliated with Meningitis and Encephalitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for genes affiliated with Meningitis and Encephalitis

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB
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Pathways related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.3SOD1, CAT
29.3SOD1, CAT
3
Show member pathways
9.3SOD1, CAT
49.3SOD1, CAT
5
Show member pathways
9.3SOD1, CAT
69.3SOD1, CAT
7
Show member pathways
9.3SOD1, CAT
8
Show member pathways
Vitamin B12 Metabolism39
9.3SOD1, CAT
9
Show member pathways
thioredoxin pathway39
8.5SOD1, CAT, CRP

Compounds for genes affiliated with Meningitis and Encephalitis

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Sources:
46Novoseek, 25HMDB, 12DrugBank
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Compounds related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1u 83836e469.8SOD1, CAT
2fpl 55712469.8SOD1, CAT
3nickel carbonate hydroxide469.8SOD1, CAT
4bathocuproine469.8SOD1, CAT
51,3-dimethyl-2-thiourea469.8CAT, SOD1
6alpha-phenyl-n-tert-butylnitrone469.8SOD1, CAT
7dmpo-oh469.8SOD1, CAT
8ionol469.7SOD1, CAT
9n-(2-mercaptopropionyl)glycine469.7SOD1, CAT
10tempol469.7SOD1, CAT
11trimetazidine469.7SOD1, CAT
12pyrogallol469.7SOD1, CAT
13zinc superoxide469.7SOD1, CAT
14oxypurinol469.7SOD1, CAT
15benzoate469.7CAT, SOD1
16propyl gallate469.7CAT, SOD1
17diphenyliodonium469.7SOD1, CAT
18ptio469.7SOD1, CAT
19nacn469.7SOD1, CAT
20dmpo469.7SOD1, CAT
21citrinin469.7SOD1, CAT
22thiourea469.7SOD1, CAT
23guaiacol46 2510.7SOD1, CAT
24semiquinone469.7SOD1, CAT
25glutathion469.6SOD1, CAT
26thiobarbituric acid469.6SOD1, CAT
273-amino-1,2,4-triazole469.6CAT, SOD1
28rutin46 1210.6CAT, SOD1
29sodium azide469.6CAT, SOD1
30randox469.5SOD1, CRP
31azide469.5SOD1, CAT
32fenton469.5CAT, SOD1
33ebselen469.5SOD1, CAT
34antimycin a469.4SOD1, CAT
35benzyl alcohol46 1210.4SOD1, CAT
36bucillamine469.4CAT, CRP
37dicoumarol469.3SOD1, CAT
38trolox469.3CAT, SOD1
39d penicillamine469.3CAT, CRP
40hocl469.2SOD1, CAT
41dehydroascorbic acid46 1210.0SOD1, CAT
428-isoprostane469.0CRP, CAT, SOD1
43betacarotene469.0CRP, CAT, SOD1
44malondialdehyde469.0SOD1, CAT, CRP
45uric acid46 259.9SOD1, CAT, CRP
46alpha tocopherol468.9CRP, CAT, SOD1
47mannitol46 129.9SOD1, CAT, CRP
48vitamin a46 25 1210.9SOD1, CAT, CRP
49n acetylcysteine468.8CRP, CAT, SOD1
50ascorbic acid46 259.8SOD1, CAT, CRP

GO Terms for genes affiliated with Meningitis and Encephalitis

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17Gene Ontology
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Cellular components related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.3CAT, SOD1
2mitochondrial intermembrane spaceGO:0057589.0CAT, SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.0CRP, CAT
2response to ethanolGO:0454718.8CRP, SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.5CRP, CAT, SOD1

Products for genes affiliated with Meningitis and Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningitis and Encephalitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet