MCID: MNN024
MIFTS: 27

Meningitis and Encephalitis malady

Summaries for Meningitis and Encephalitis

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43NINDS, 32MalaCards
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NINDS:43 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

MalaCards: Meningitis and Encephalitis is related to encephalitis and meningitis. An important gene associated with Meningitis and Encephalitis is NTF4 (neurotrophin 4), and among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and p75(NTR)-mediated signaling. The compounds superoxide and bucillamine have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

Aliases & Classifications for Meningitis and Encephalitis

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43NINDS
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Aliases & Descriptions:

meningitis and encephalitis 43


Related Diseases for Meningitis and Encephalitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to meningitis and encephalitis

Clinical Features for Meningitis and Encephalitis

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Drugs & Therapeutics for Meningitis and Encephalitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meningitis and Encephalitis

Drug clinical trials:

Search ClinicalTrials for Meningitis and Encephalitis

Search NIH Clinical Center for Meningitis and Encephalitis

Search CenterWatch for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

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Anatomical Context for Meningitis and Encephalitis

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32MalaCards
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MalaCards organs/tissues related to Meningitis and Encephalitis:

32
Brain, Spinal cord

Animal Models for Meningitis and Encephalitis or affiliated genes

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Publications for Meningitis and Encephalitis

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Genetic Variations for Meningitis and Encephalitis

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Expression for genes affiliated with Meningitis and Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for genes affiliated with Meningitis and Encephalitis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Compounds for genes affiliated with Meningitis and Encephalitis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1superoxide44 2411.4NTF3
2bucillamine449.6CAT, CRP
3vitamin a44 11 2411.6CAT
4randox449.6SOD1, CRP
5fpl 55712449.5CAT, SOD1
6bathocuproine449.5SOD1, CAT
7nickel carbonate hydroxide449.5SOD1, CAT
8u 83836e449.5CAT, SOD1
91,3-dimethyl-2-thiourea449.5SOD1, CAT
10ionol449.5CAT, SOD1
11dmpo-oh449.4SOD1, CAT
12n-(2-mercaptopropionyl)glycine449.4SOD1, CAT
13alpha-phenyl-n-tert-butylnitrone449.4SOD1, CAT
14tempol449.4SOD1, CAT
15trimetazidine449.4CAT, SOD1
16zinc superoxide449.4SOD1, CAT
17pyrogallol449.4SOD1, CAT
18oxypurinol449.4SOD1, CAT
19d penicillamine449.4CAT, CRP
20propyl gallate449.4SOD1, CAT
21benzoate449.4CAT, SOD1
22diphenyliodonium449.4SOD1, CAT
23ptio449.4SOD1, CAT
24nacn449.4CAT, SOD1
25thiourea449.4SOD1, CAT
26rasagiline44 1110.3CAT, GDNF
27citrinin449.3SOD1, CAT
28dmpo449.3CAT, SOD1
29riluzole44 28 1111.3SOD1, GDNF
30guaiacol44 2410.3CAT, SOD1
31thiobarbituric acid449.3CAT, SOD1
32semiquinone449.3SOD1, CAT
333-amino-1,2,4-triazole449.3CAT, SOD1
34choline44 11 2411.2NTF3, GDNF, NTF4
35rutin44 1110.2CAT, SOD1
36citrate449.2NTF4, CRP, CAT
37sodium azide449.1SOD1, CAT
38antimycin a449.0SOD1, CAT
39acetylcholine44 49 28 11 2413.0GDNF, CRP, NTF4, NTF3
40vitamin-e449.0CAT, SOD1, NTF3
41selegiline44 1110.0CAT, SOD1, GDNF
428-isoprostane449.0SOD1, CAT, CRP
436-hydroxydopamine448.9SOD1, CAT, GDNF
44betacarotene448.9CAT, CRP, SOD1
45malondialdehyde448.9CRP, SOD1, CAT
46azide448.9CAT, SOD1
47uric acid44 249.9CRP, SOD1, CAT
48levodopa44 119.9GDNF, SOD1, CAT
49mannitol44 119.8SOD1, CRP, CAT
50iron44 249.4CAT, SOD1, CRP, GDNF

GO Terms for genes affiliated with Meningitis and Encephalitis

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16Gene Ontology
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Cellular components related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7GDNF, NTF3, NTF4, CRP, SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mechanoreceptor differentiationGO:0424909.6NTF3, NTF4
2adult locomotory behaviorGO:0083449.5GDNF, NTF4
3enteric nervous system developmentGO:0484849.2GDNF, NTF3
4negative regulation of neuron apoptotic processGO:0435248.6GDNF, NTF3, SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.9GDNF, NTF3, CAT
2growth factor activityGO:0080838.8NTF4, NTF3, GDNF
3protein homodimerization activityGO:0428037.9GDNF, CRP, SOD1, CAT

Products for genes affiliated with Meningitis and Encephalitis

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  • Antibodies
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Sources for Meningitis and Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet