MCID: MNN024
MIFTS: 32

Meningitis and Encephalitis malady

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Summaries for Meningitis and Encephalitis

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NINDS:43 Meningitis and encephalitis are inflammatory diseases of the membranes that surround the brain and spinal cord and are caused by bacterial or viral infections. Viral meningitis is sometimes called aseptic meningitis to indicate it is not the result of bacterial infection and cannot be treated with antibiotics. Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

MalaCards based summary: Meningitis and Encephalitis is related to meningitis and encephalitis. An important gene associated with Meningitis and Encephalitis is CAT (catalase), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and Peroxisome. The compounds u 83836e and fpl 55712 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes.

Aliases & Classifications for Meningitis and Encephalitis

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Meningitis and Encephalitis, Aliases & Descriptions:

Name: Meningitis and Encephalitis 43


Related Diseases for Meningitis and Encephalitis

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Diseases related to Meningitis and Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.2CRP, CAT
2encephalitis10.8
3viral meningitis10.6
4aseptic meningitis10.5
5hypermethioninemia10.4SOD1
6diabetic cataract10.4CAT
7gastritis10.3CAT
8bacteriuria10.3CRP
9measles10.3
10poliomyelitis10.3
11systemic lupus erythematosus10.2CRP
12vascular disease10.2CAT
13pneumoconiosis10.1SOD1, CAT
14senile cataract10.1CAT, SOD1
15wilson disease10.1CAT, SOD1
16alcoholic liver cirrhosis10.1CAT, SOD1
17chronic granulomatous disease10.1SOD1, CAT
18relapsing polychondritis10.1
19mumps10.1
20meningoencephalitis10.1
21parotitis10.1
22scarlet fever10.1
23cerebritis10.1
24bacterial meningitis10.1
25herpes simplex10.1
26herpes simplex encephalitis10.1
27west nile virus10.1
28male infertility10.1CAT, SOD1
29vitiligo10.1SOD1, CAT
30cataract10.1SOD1, CAT
31tonsillitis10.0SOD1, CRP
32hyperhomocysteinemia10.0SOD1, CRP
33uremia10.0CRP, SOD1
34bacteremia10.0CRP, CAT
35acute pancreatitis10.0SOD1, CRP
36osteomyelitis10.0CAT, CRP
37cork-handlers' disease10.0SOD1, CAT
38pancreatitis10.0SOD1, CRP
39spiradenoma10.0CRP, CAT
40tuberculosis10.0CRP
41parkinson's disease10.0CAT, SOD1
42primary hyperoxaluria10.0CRP, CAT
43coronary artery anomaly9.9SOD1, CRP
44galactosemia9.9CRP, CAT
45pre-eclampsia9.9CAT, SOD1
46congenital heart disease9.9CAT, CRP
47acute myocardial infarction9.9CAT, CRP
48hyperglycemia9.8SOD1, CAT, CRP
49chronic kidney failure9.8SOD1, CRP, CAT
50type 2 diabetes mellitus9.8SOD1, CAT, CRP

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to meningitis and encephalitis

Symptoms for Meningitis and Encephalitis

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Drugs & Therapeutics for Meningitis and Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Meningitis and Encephalitis

Search NIH Clinical Center for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

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Anatomical Context for Meningitis and Encephalitis

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MalaCards organs/tissues related to Meningitis and Encephalitis:

32
Brain, Spinal cord, Testes, B cells

Animal Models for Meningitis and Encephalitis or affiliated genes

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Publications for Meningitis and Encephalitis

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Articles related to Meningitis and Encephalitis:

(show all 22)
idTitleAuthorsYear
1
Viral meningitis and encephalitis. (23981453)
2013
2
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. (23235298)
2012
3
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. (22123531)
2012
4
Establishing surveillance for acute meningitis and encephalitis syndromes through expansion of poliomyelitis and measles surveillance networks in Bangladesh,China and India, 2006a892008. (23311008)
2012
5
Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab. (21622521)
2011
6
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. (21292281)
2011
7
Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. (18637823)
2008
8
Etiology of aseptic meningitis and encephalitis in an adult population. (16401850)
2006
9
Evaluation of antioxidant status in children with acute bacterial meningitis and encephalitis. (14585750)
2003
10
Viral meningitis and encephalitis: traditional and emerging viral agents. (12881794)
2003
11
Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis. (11018820)
2000
12
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. (9705409)
1998
13
Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis. (9504768)
1997
14
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. (9041414)
1997
15
Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. (9424322)
1997
16
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. (8890768)
1996
17
Viral meningitis and encephalitis. (1455104)
1992
18
Viral meningitis and encephalitis in Saudi Arabia. (2585577)
1989
19
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. (3135367)
1988
20
Mumps virus meningitis and encephalitis without parotitis. (750438)
1978
21
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. (5410113)
1970
22
Acute serous meningitis and encephalitis complicating scarlet fever. (18118945)
1949

Variations for Meningitis and Encephalitis

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Expression for genes affiliated with Meningitis and Encephalitis

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Expression patterns in normal tissues for genes affiliated with Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for genes affiliated with Meningitis and Encephalitis

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Pathways related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.3SOD1, CAT
29.3SOD1, CAT
3
Show member pathways
9.3SOD1, CAT
49.3SOD1, CAT
5
Show member pathways
9.3SOD1, CAT
69.3SOD1, CAT
7
Show member pathways
9.3SOD1, CAT
8
Show member pathways
Vitamin B12 Metabolism37
9.3SOD1, CAT
9
Show member pathways
thioredoxin pathway37
8.5SOD1, CAT, CRP

Compounds for genes affiliated with Meningitis and Encephalitis

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Sources:
44Novoseek, 24HMDB, 11DrugBank
See all sources

Compounds related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1u 83836e449.8CAT, SOD1
2fpl 55712449.8CAT, SOD1
3bathocuproine449.8CAT, SOD1
4nickel carbonate hydroxide449.8SOD1, CAT
51,3-dimethyl-2-thiourea449.8SOD1, CAT
6ionol449.8SOD1, CAT
7n-(2-mercaptopropionyl)glycine449.8CAT, SOD1
8dmpo-oh449.7CAT, SOD1
9alpha-phenyl-n-tert-butylnitrone449.7SOD1, CAT
10trimetazidine449.7SOD1, CAT
11tempol449.7SOD1, CAT
12oxypurinol449.7SOD1, CAT
13pyrogallol449.7SOD1, CAT
14zinc superoxide449.7SOD1, CAT
15propyl gallate449.7CAT, SOD1
16benzoate449.7SOD1, CAT
17diphenyliodonium449.7SOD1, CAT
18nacn449.7CAT, SOD1
19ptio449.7SOD1, CAT
20citrinin449.7SOD1, CAT
21dmpo449.7SOD1, CAT
22thiourea449.7CAT, SOD1
23thiobarbituric acid449.7CAT, SOD1
24glutathion449.7CAT, SOD1
25semiquinone449.6SOD1, CAT
26guaiacol44 2410.6CAT, SOD1
273-amino-1,2,4-triazole449.6SOD1, CAT
28rutin44 1110.6SOD1, CAT
29sodium azide449.6CAT, SOD1
30randox449.5SOD1, CRP
31azide449.5CAT, SOD1
32fenton449.5SOD1, CAT
33ebselen449.5CAT, SOD1
34benzyl alcohol44 1110.4CAT, SOD1
35antimycin a449.4SOD1, CAT
36bucillamine449.4CAT, CRP
37dehydroascorbic acid44 1110.3SOD1, CAT
38trolox449.3SOD1, CAT
39d penicillamine449.3CAT, CRP
40dicoumarol449.2CAT, SOD1
41hocl449.0SOD1, CAT
428-isoprostane449.0CRP, SOD1, CAT
43betacarotene449.0CAT, CRP, SOD1
44malondialdehyde449.0SOD1, CAT, CRP
45uric acid44 249.9SOD1, CAT, CRP
46alpha tocopherol448.9CAT, SOD1, CRP
47mannitol44 119.9SOD1, CRP, CAT
48vitamin a44 24 1110.9SOD1, CAT, CRP
49n acetylcysteine448.8CRP, SOD1, CAT
50ascorbic acid44 249.8CRP, CAT, SOD1

GO Terms for genes affiliated with Meningitis and Encephalitis

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Cellular components related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.3CAT, SOD1
2mitochondrial intermembrane spaceGO:0057589.0CAT, SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.0CRP, CAT
2response to ethanolGO:0454718.8CRP, SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.5CRP, CAT, SOD1

Products for genes affiliated with Meningitis and Encephalitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Meningitis and Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet