MCID: MNN024
MIFTS: 30

Meningitis and Encephalitis malady

Aliases & Classifications for Meningitis and Encephalitis

Aliases & Descriptions for Meningitis and Encephalitis:

Name: Meningitis and Encephalitis 51

Summaries for Meningitis and Encephalitis

NINDS : 51 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone can get encephalitis or meningitis.Inflammation from encephalitis and meningitis produce a wide range of symptoms.  Symptoms of encephalitis include sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, and irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia.

MalaCards based summary : Meningitis and Encephalitis is related to meningoencephalitis and meningitis. An important gene associated with Meningitis and Encephalitis is ALB (Albumin), and among its related pathways/superpathways are Longevity regulating pathway and Amyotrophic lateral sclerosis (ALS). The drugs Heptavalent Pneumococcal Conjugate Vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cellular and neoplasm

Related Diseases for Meningitis and Encephalitis

Diseases related to Meningitis and Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 meningoencephalitis 10.9
2 meningitis 10.3
3 encephalitis 10.3
4 tenosynovitis 10.1 ALB SOD1
5 viral meningitis 10.0
6 stickler sydrome, type i, nonsyndromic ocular 10.0 CAT SOD1
7 myositis fibrosa 10.0 CAT SOD1
8 sacrococcygeal teratoma 10.0 CAT SOD1
9 histiocytoid hemangioma 10.0 ALB SOD1
10 aseptic meningitis 10.0
11 pseudo-gaucher disease 10.0 CAT SOD1
12 cerebral folate receptor alpha deficiency 10.0 CP SOD1
13 rosacea 10.0 ALB CP
14 chronic tic disorder 10.0 ALB SOD1
15 ectodermal dysplasia bartalos type 9.9 CP SOD1
16 isolated growth hormone deficiency 9.9 ALB CP
17 bladder sarcoma 9.9 ALB CP
18 choroiditis 9.9 ALB CP
19 chronic myocardial ischemia 9.9 ALB SOD1
20 mucinous ovarian cystadenoma 9.9 CAT SOD1
21 episcleritis periodica fugax 9.9 CAT CP
22 paragonimiasis 9.9 ALB CP
23 central nervous system leiomyoma 9.9 ALB CP
24 pericarditis 9.8 ALB CAT SOD1
25 substance-induced psychosis 9.8 ALB SOD1
26 poliomyelitis 9.7
27 measles 9.7
28 baritosis 9.7 CAT CP SOD1
29 auditory neuropathy, autosomal dominant, 1 9.7 ALB CAT CP
30 neuronal ceroid-lipofuscinoses 9.7 ALB CAT CP
31 relapsing polychondritis 9.6
32 cerebritis 9.6
33 herpes simplex 9.6
34 scarlet fever 9.6
35 bacterial meningitis 9.6
36 herpes simplex encephalitis 9.6
37 west nile virus 9.6
38 mumps 9.6
39 parotitis 9.6
40 neurological manifestations of pompe disease 9.5 ALB CAT CP SOD1

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to Meningitis and Encephalitis

Symptoms & Phenotypes for Meningitis and Encephalitis

MGI Mouse Phenotypes related to Meningitis and Encephalitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.26 CP SOD1 ALB CAT
2 neoplasm MP:0002006 8.8 SOD1 ALB CAT

Drugs & Therapeutics for Meningitis and Encephalitis

Drugs for Meningitis and Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3
2 Vaccines Phase 4,Phase 3
3 Neuromuscular Blocking Agents Phase 4
4
Menthol Approved Phase 3 2216-51-5 16666
5
Lactitol Phase 3 585-86-4 3871
6
Fluconazole Approved Phase 2 86386-73-4 3365
7
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
8
Tamoxifen Approved Phase 2 10540-29-1 2733526
9
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
10
Hydroxychloroquine Approved Phase 2 118-42-3 3652
11 Steroid Synthesis Inhibitors Phase 2
12 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
13 Cytochrome P-450 Enzyme Inhibitors Phase 2
14 Hormone Antagonists Phase 2
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Anti-Bacterial Agents Phase 2
18 Immunoglobulins Phase 1, Phase 2
19 Anti-Infective Agents Phase 2
20 Antibodies, Monoclonal Phase 1, Phase 2
21 Antifungal Agents Phase 2
22 Antimalarials Phase 2
23 Antibodies Phase 1, Phase 2
24 Antiparasitic Agents Phase 2
25 Antiprotozoal Agents Phase 2
26 Selective Estrogen Receptor Modulators Phase 2
27 Cytochrome P-450 CYP3A Inhibitors Phase 2
28 Estrogen Antagonists Phase 2
29 Estrogen Receptor Modulators Phase 2
30 Estrogens Phase 2
31 Liposomal amphotericin B Phase 2
32 Antirheumatic Agents Phase 2
33 Antineoplastic Agents, Hormonal Phase 2
34 Bone Density Conservation Agents Phase 2
35
Dopamine Approved 51-61-6, 62-31-7 681
36
Acetaminophen Approved 103-90-2 1983
37
Ceftriaxone Approved 73384-59-5 5479530 5361919
38
Fosfomycin Approved 23155-02-4 446987
39
Granisetron Approved, Investigational 109889-09-0 3510
40
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
41
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
42 Acyclovir
43 dipyrone
44 Gastrointestinal Agents
45 Neurotransmitter Agents
46 Peripheral Nervous System Agents
47 Dopamine Agents
48 Dopamine Antagonists
49 Antiemetics
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
2 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
3 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
4 Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults Completed NCT00492557 Phase 3
5 The NEUROlogically-impaired Extubation Timing Trial Recruiting NCT02920580 Phase 3
6 Phase Ib Study of SC Milatuzumab in SLE Recruiting NCT01845740 Phase 1, Phase 2
7 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2
8 Study of Anti-Malarials in Incomplete Lupus Erythematosus Not yet recruiting NCT03030118 Phase 2
9 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
10 Side Effects of Bone Marrow Derived CD133 Transplantation in Cerebral Palsy Completed NCT01404663 Phase 1
11 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1
12 Long Term Outcomes of EV71 CNS Infection Unknown status NCT00172393
13 Nervous System Infections Among Patients With Febrile Seizure Completed NCT01694524
14 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
15 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
16 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
17 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Recruiting NCT02868593
18 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469
19 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Recruiting NCT02624453
20 Tick-borne Encephalitis and Positive Borrelial Antibodies Recruiting NCT02463942
21 Fosfomycin i.v. for Treatment of Severely Infected Patients Recruiting NCT02979951
22 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
23 Singapore Neurologic Infections Program Active, not recruiting NCT02017665
24 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
25 Genetic Susceptibility and Biomarkers in Listeriosis (MONALISA-GENBIO) Enrolling by invitation NCT02924220
26 Epidemiology and Prognosis of Encephalitis in Intensive Care Not yet recruiting NCT02906631
27 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504
28 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

Anatomical Context for Meningitis and Encephalitis

MalaCards organs/tissues related to Meningitis and Encephalitis:

39
Brain, Spinal Cord, Testes, B Cells

Publications for Meningitis and Encephalitis

Articles related to Meningitis and Encephalitis:

(show all 23)
id Title Authors Year
1
Infectious Meningitis and Encephalitis. ( 27643906 )
2016
2
Viral meningitis and encephalitis. ( 23981453 )
2013
3
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. ( 23235298 )
2012
4
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. ( 22123531 )
2012
5
Establishing surveillance for acute meningitis and encephalitis syndromes through expansion of poliomyelitis and measles surveillance networks in Bangladesh,China and India, 2006a892008. ( 23311008 )
2012
6
Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab. ( 21622521 )
2011
7
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
8
Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. ( 18637823 )
2008
9
Etiology of aseptic meningitis and encephalitis in an adult population. ( 16401850 )
2006
10
Viral meningitis and encephalitis: traditional and emerging viral agents. ( 12881794 )
2003
11
Evaluation of antioxidant status in children with acute bacterial meningitis and encephalitis. ( 14585750 )
2003
12
Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis. ( 11018820 )
2000
13
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9705409 )
1998
14
Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9504768 )
1997
15
[Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. ( 9424322 )
1997
16
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. ( 9041414 )
1997
17
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. ( 8890768 )
1996
18
Viral meningitis and encephalitis. ( 1455104 )
1992
19
Viral meningitis and encephalitis in Saudi Arabia. ( 2585577 )
1989
20
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. ( 3135367 )
1988
21
Mumps virus meningitis and encephalitis without parotitis. ( 750438 )
1978
22
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. ( 5410113 )
1970
23
Acute serous meningitis and encephalitis complicating scarlet fever. ( 18118945 )
1949

Variations for Meningitis and Encephalitis

Expression for Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for Meningitis and Encephalitis

GO Terms for Meningitis and Encephalitis

Cellular components related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 ALB CAT CP SOD1
2 extracellular region GO:0005576 9.46 ALB CAT CP SOD1
3 blood microparticle GO:0072562 9.4 ALB CP
4 myelin sheath GO:0043209 9.37 ALB SOD1
5 peroxisome GO:0005777 9.26 CAT SOD1
6 mitochondrial intermembrane space GO:0005758 8.96 CAT SOD1
7 extracellular space GO:0005615 8.92 ALB CAT CP SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.61 CAT CP SOD1
2 aging GO:0007568 9.51 CAT SOD1
3 negative regulation of apoptotic process GO:0043066 9.5 ALB CAT SOD1
4 response to oxidative stress GO:0006979 9.49 CAT SOD1
5 platelet degranulation GO:0002576 9.48 ALB SOD1
6 response to ethanol GO:0045471 9.46 CAT SOD1
7 cellular response to oxidative stress GO:0034599 9.4 CAT SOD1
8 cellular oxidant detoxification GO:0098869 9.37 ALB CAT
9 response to hydrogen peroxide GO:0042542 9.26 CAT SOD1
10 cellular iron ion homeostasis GO:0006879 9.16 CP SOD1
11 retina homeostasis GO:0001895 8.96 ALB SOD1
12 response to reactive oxygen species GO:0000302 8.62 CAT SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 CAT CP SOD1
2 chaperone binding GO:0051087 9.33 ALB CP SOD1
3 copper ion binding GO:0005507 9.13 ALB CP SOD1
4 antioxidant activity GO:0016209 8.8 ALB CAT SOD1

Sources for Meningitis and Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....