MCID: MNN007
MIFTS: 36

Meningocele malady

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Meningocele

Aliases & Descriptions for Meningocele:

Name: Meningocele 12 50 29 52 42 14 69
Congenital Meningocele 69
Spinal Meningocele 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 42 D008588
UMLS 69 C0025299

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to neural tube defects and lateral meningocele syndrome. An important gene associated with Meningocele is MNX1 (Motor Neuron And Pancreas Homeobox 1). Affiliated tissues include spinal cord, bone and skin, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
id Related Disease Score Top Affiliating Genes
1 neural tube defects 31.8 MNX1 VANGL1
2 lateral meningocele syndrome 12.4
3 cranial meningocele 11.9
4 posterior meningocele 11.9
5 sacral meningocele conotruncal heart defects 11.9
6 caudal regression syndrome 11.7
7 currarino syndrome 11.1
8 currarino triad 11.1
9 sacrococcygeal teratoma 11.1
10 neurofibromatosis 10.3
11 cervicitis 10.1
12 meningitis 10.1
13 neurofibromatosis, type 1 10.1
14 ovarian cyst 9.9
15 marfan syndrome 9.9
16 fibrous dysplasia 9.9 MNX1 SATB2
17 dandy-walker syndrome 9.9
18 encephalocele 9.9
19 dermoid cyst 9.9
20 meningoencephalocele 9.9
21 mucositis 9.8 MNX1 SATB2
22 cerebritis 9.8
23 hemorrhagic destruction of the brain, subependymal calcification, and cataracts 9.7 ADAMTS18 SATB2
24 teratoma 9.7
25 bacterial meningitis 9.7
26 hydrocephalus 9.7
27 arachnoiditis 9.7
28 neurofibroma 9.7
29 myelomeningocele 9.7
30 arachnoid cysts 9.7
31 diastematomyelia 9.7
32 cauda equina syndrome 9.6
33 spinal intradural arachnoid cysts 9.6
34 amniotic band syndrome 9.6
35 intracranial hypotension 9.6
36 aneurysm 9.6
37 cerebrospinal fluid leak 9.6
38 chiari malformation 9.6
39 constipation 9.6
40 pharyngitis 9.6
41 syncope 9.6
42 klippel-feil syndrome 9.6
43 lipoma 9.6
44 imperforate anus 9.6
45 mediastinitis 9.6
46 choroiditis 9.6
47 syringomyelia 9.6
48 alopecia 9.5
49 teratocarcinoma 9.5
50 exophthalmos 9.5

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 MNX1 NF1 NOTCH3 SATB2 VANGL1
2 growth/size/body region MP:0005378 9.63 ADAMTS18 MNX1 NF1 NOTCH3 SATB2 VANGL1
3 respiratory system MP:0005388 9.35 NOTCH3 SATB2 VANGL1 MNX1 NF1
4 skeleton MP:0005390 9.1 ADAMTS18 MNX1 NF1 NOTCH3 SATB2 VANGL1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


id Name Status NCT ID Phase
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

id Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

39
Spinal Cord, Bone, Skin, Eye, Heart, Breast, Uterus

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 555)
id Title Authors Year
1
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
2
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
3
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
4
Meningocele and Meningoencephalocele of the Lateral Wall of the Sphenoid Sinus. ( 26732955 )
2016
5
Giant Intrathoracic Meningocele and Breast Cancer in a Neurofibromatosis Type I Patient. ( 27847582 )
2016
6
Spina Bifida, Meningomyelocele, and Meningocele. ( 26725976 )
2016
7
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016
8
Neurosurgical management in lateral meningocele syndrome: case report. ( 27911244 )
2016
9
Successful management of a giant anterior sacral meningocele with an endoscopic cutting stapler: case report. ( 26745349 )
2016
10
Differential diagnosis of anterior sacral meningocele during the evaluation of post-hysterectomy pelvic collections. ( 27403027 )
2016
11
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
12
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
13
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
14
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
15
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
16
Lateral meningocele (Lehman) syndrome: A child with a novel NOTCH3 mutation. ( 26754023 )
2016
17
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
18
Correlation of Oxidative Damage with Pro-Inflammatory Markers (IL-6, TNF-I+) in Meningocele. ( 27042444 )
2016
19
Nasal meningocele. ( 28039144 )
2016
20
Dizziness caused by meningocele-associated intracranial hypotension in neurofibromatosis type 1. ( 27765822 )
2016
21
Type I Cutaneous Meningioma (Rudimentary Meningocele) With Intradural Attachment to the Phylum Terminale. ( 27828803 )
2016
22
Currarino Syndrome and the Effect of a Large Anterior Sacral Meningocele on Distal Colostogram in an Anorectal Malformation. ( 27761181 )
2016
23
Neck swelling due to skull base (pseudo)meningocele protruding through a congenital skull base bone defect: a case report. ( 27830332 )
2016
24
Thoracic meningocele in lumbo-costo-vertebral syndrome in a child: possible enlargement with repeated motion by anchoring to the diaphragm. ( 27058456 )
2016
25
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
26
OPTIC NERVE MENINGOCELE SIMULATING EXTRAOCULAR EXTENSION OF CHOROIDAL MELANOMA. ( 27617394 )
2016
27
Congenital lordoscoliosis and stenosis of the external ostium of the foraminal canal induced by a nonsegmented transversal bony bar associated to rachischisis and meningocele. ( 26022674 )
2015
28
Lateral meningocele with asymmetric canal stenosis: A case study. ( 25561891 )
2015
29
Congenital Jejunal Tubular Duplication in a Patient with a Congenital Thoracic Meningocele. ( 26601745 )
2015
30
True Cervicothoracic Meningocele: A Rare and Benign Condition. ( 26788266 )
2015
31
Internal auditory canal meningocele-perilabyrinthine/translabyrinthine fistula: Case report and imaging. ( 26651061 )
2015
32
Congenital Jejunal Tubular Duplication in a Patient with a Congenital Thoracic Meningocele. ( 26350649 )
2015
33
Intramedullary spinal epidermoid presenting after thoracic meningocele repair: case report. ( 25815631 )
2015
34
Anterior Sacral Meningocele Masquerading as an Ovarian Cyst: A Rare Clinical Presentation Associated with Marfan Syndrome. ( 26236457 )
2015
35
Collaborative treatment of huge intrathoracic meningoceles associated with neurofibromatosis type 1: a case report. ( 26556010 )
2015
36
Neurosurgical management of a large meningocele in Jarcho-Levin syndrome: clinical and radiological pearls. ( 26199296 )
2015
37
Is repair of the protruded meninges sufficient for treatment of meningocele? ( 26298824 )
2015
38
IMAGES IN CLINICAL MEDICINE. Cervical Meningocele. ( 26200992 )
2015
39
Cervical vertebral fusion with anterior meningocele. ( 25923673 )
2015
40
Anesthetic management of a newborn with occipital meningocele for magnetic resonance imaging. ( 26417133 )
2015
41
Two cases of meningocele and meningoencephalocele in Jeju native pigs. ( 25889174 )
2015
42
Rare cause of trigeminal neuralgia: Meckel's cave meningocele. ( 25951909 )
2015
43
Massive spontaneous hemothorax, giant intrathoracic meningocele, and kyphoscoliosis in neurofibromatosis type 1. ( 25013551 )
2014
44
Midface anomaly in a neonate: nasal-ethmoidal meningocele. ( 24668833 )
2014
45
Unruptured translabyrinthine meningocele without CSF otorrhea. ( 24480122 )
2014
46
Truncating mutations in the last exon of NOTCH3 cause lateral meningocele syndrome. ( 25394726 )
2014
47
Case of rudimentary meningocele in identical twin sisters. ( 24612009 )
2014
48
Holocord syringomyelia secondary to tethered spinal cord associated with anterior sacral meningocele and tailgut cyst: case report and review of literature. ( 24562417 )
2014
49
Late diagnosis of lateral meningocele syndrome in a 55-year-old woman with symptoms of joint instability and chronic musculoskeletal pain. ( 24311540 )
2014
50
Endoscopic endonasal repair of spontaneous sphenoid sinus lateral wall meningocele presenting with cerebrospinal fluid leak. ( 24966559 )
2014

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.43 HSF4 MNX1 SATB2
2 pigmentation GO:0043473 9.16 NF1 VANGL1
3 eye development GO:0001654 8.96 ADAMTS18 HSF4
4 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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