MCID: MNN007
MIFTS: 38

Meningocele

Categories: Rare diseases, Fetal diseases, Neuronal diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 72 49 28 51 41 14 69
Congenital Meningocele 69
Spinal Meningocele 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 41 D008588

Summaries for Meningocele

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Spina bifida and Neural tube defects.

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to arachnoiditis and anus, imperforate. An important gene associated with Meningocele is NOTCH3 (Notch 3). Affiliated tissues include spinal cord, bone and skin, and related phenotypes are respiratory system and skeleton

Wikipedia : 72 Spina bifida is a birth defect where there is incomplete closing of the backbone and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 arachnoiditis 29.7 C2 MNX1
2 anus, imperforate 29.2 MNX1 SATB2
3 lateral meningocele syndrome 12.5
4 sacral defect with anterior meningocele 12.4
5 cranial meningocele 12.0
6 posterior meningocele 12.0
7 sacral meningocele conotruncal heart defects 12.0
8 neural tube defects 11.5
9 currarino syndrome 11.4
10 myelomeningocele 11.4
11 sacrococcygeal teratoma 11.2
12 curry-jones syndrome 10.9
13 neurofibromatosis, type iv, of riccardi 10.4
14 cervicitis 10.2
15 meningitis 10.2
16 meningoencephalocele 10.0
17 telecanthus 10.0 ADAMTS18 NOTCH3
18 marfan syndrome 10.0
19 ovarian cyst 10.0
20 encephalocele 10.0
21 cleft palate, isolated 10.0
22 dandy-walker syndrome 10.0
23 dermoid cyst 10.0
24 teratoma 9.9
25 meningioma, familial 9.9
26 episodic pain syndrome, familial, 1 9.9
27 cerebritis 9.9
28 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
29 diastematomyelia 9.8
30 hydrocephalus 9.8
31 bacterial meningitis 9.8
32 neurofibroma 9.8
33 arachnoid cysts 9.8
34 epidermoid cysts 9.7
35 lipomatosis, multiple 9.7
36 spinal intradural arachnoid cysts 9.7
37 neural tube defects, folate-sensitive 9.7
38 siderosis 9.7
39 klippel-feil syndrome 9.7
40 choroiditis 9.7
41 cauda equina syndrome 9.7
42 squamous cell carcinoma 9.7
43 constipation 9.7
44 pharyngitis 9.7
45 syringomyelia 9.7
46 intracranial hypotension 9.7
47 mediastinitis 9.7
48 amniotic band syndrome 9.7
49 cerebrospinal fluid leak 9.7
50 chiari malformation 9.7

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.35 MNX1 NF1 NOTCH3 SATB2 VANGL1
2 skeleton MP:0005390 9.02 MNX1 NF1 NOTCH3 SATB2 VANGL1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 28

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

38
Spinal Cord, Bone, Skin, Eye, Uterus, Heart

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 578)
# Title Authors Year
1
Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )
2018
2
Fungating Growth of Squamous Cell Carcinoma in Long-Standing Meningocele. ( 29393254 )
2018
3
Retained medullary cord extending to a sacral subcutaneous meningocele. ( 29101613 )
2018
4
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
5
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
6
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
7
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
8
Pulsatile Proptosis due to Intraorbital Meningocele. ( 28674516 )
2017
9
Imaging Findings of Jugular Foramen Meningocele in a Neurofibromatosis Type 1 Patient. ( 29435380 )
2017
10
Anterior sacral meningocele presenting as intracystic bleeding. ( 28523383 )
2017
11
Thalidomide Embryopathy as Possible Cause of Anterior Sacral Meningocele: A Case Report. ( 28990356 )
2017
12
Encephalocele development from a congenital meningocele: case report. ( 28885087 )
2017
13
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report. ( 28621617 )
2017
14
Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma - a case report. ( 29216848 )
2017
15
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. ( 28746249 )
2017
16
Meningocele manquAc. ( 28478392 )
2017
17
Multidisciplinary surgical treatment of presacral meningocele and teratoma in an adult with Currarino triad. ( 28584680 )
2017
18
Meningocele manquAc: a comprehensive review of this enigmatic finding in occult spinal dysraphism. ( 28620735 )
2017
19
Stabilization of Visual Function After Optic Nerve Sheath Fenestration for Optic Nerve Meningocele. ( 28538611 )
2017
20
Unusual Presentation of Intrasacral Meningocele: A Case Report and Overview. ( 28553381 )
2017
21
Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. ( 28247440 )
2017
22
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus. ( 29059790 )
2017
23
Differential diagnosis of anterior sacral meningocele during the evaluation of post-hysterectomy pelvic collections. ( 27403027 )
2016
24
OPTIC NERVE MENINGOCELE SIMULATING EXTRAOCULAR EXTENSION OF CHOROIDAL MELANOMA. ( 27617394 )
2016
25
Neurosurgical management in lateral meningocele syndrome: case report. ( 27911244 )
2016
26
Nasal meningocele. ( 28039144 )
2016
27
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
28
Thoracic meningocele in lumbo-costo-vertebral syndrome in a child: possible enlargement with repeated motion by anchoring to the diaphragm. ( 27058456 )
2016
29
Neck swelling due to skull base (pseudo)meningocele protruding through a congenital skull base bone defect: a case report. ( 27830332 )
2016
30
Correlation of Oxidative Damage with Pro-Inflammatory Markers (IL-6, TNF-I+) in Meningocele. ( 27042444 )
2016
31
Spina Bifida, Meningomyelocele, and Meningocele. ( 26725976 )
2016
32
Type I Cutaneous Meningioma (Rudimentary Meningocele) With Intradural Attachment to the Phylum Terminale. ( 27828803 )
2016
33
Successful management of a giant anterior sacral meningocele with an endoscopic cutting stapler: case report. ( 26745349 )
2016
34
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
35
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
36
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
37
Meningocele and Meningoencephalocele of the Lateral Wall of the Sphenoid Sinus. ( 26732955 )
2016
38
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
39
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
40
Dizziness caused by meningocele-associated intracranial hypotension in neurofibromatosis type 1. ( 27765822 )
2016
41
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
42
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
43
Lateral meningocele (Lehman) syndrome: A child with a novel NOTCH3 mutation. ( 26754023 )
2016
44
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016
45
Giant Intrathoracic Meningocele and Breast Cancer in a Neurofibromatosis Type I Patient. ( 27847582 )
2016
46
Squamous cell carcinoma arising from neglected meningocele. ( 28194302 )
2016
47
Currarino Syndrome and the Effect of a Large Anterior Sacral Meningocele on Distal Colostogram in an Anorectal Malformation. ( 27761181 )
2016
48
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
49
Anterior sacral meningocele presenting with purulent rectal discharge and altered mental status. ( 29443196 )
2015
50
Lateral meningocele with asymmetric canal stenosis: A case study. ( 25561891 )
2015

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pigmentation GO:0043473 9.16 NF1 VANGL1
2 eye development GO:0001654 8.96 ADAMTS18 HSF4
3 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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