MCID: MNN007
MIFTS: 35

Meningocele

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 50 29 52 42 14 69
Congenital Meningocele 69
Spinal Meningocele 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 42 D008588
UMLS 69 C0025299

Summaries for Meningocele

NIH Rare Diseases : 50 this condition doesn't have a summary yet. please see our page(s) on spina bifida and neural tube defects.

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to caudal regression syndrome and lateral meningocele syndrome. An important gene associated with Meningocele is NOTCH3 (Notch 3). Affiliated tissues include spinal cord, bone and eye, and related phenotypes are respiratory system and skeleton

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 caudal regression syndrome 32.6 MNX1 VANGL1
2 lateral meningocele syndrome 12.4
3 cranial meningocele 11.9
4 posterior meningocele 11.9
5 sacral meningocele conotruncal heart defects 11.8
6 currarino syndrome 11.3
7 neural tube defects 11.1
8 sacrococcygeal teratoma 11.1
9 curry-jones syndrome, somatic mosaic 10.8
10 cervicitis 10.1
11 meningitis 10.1
12 neurofibromatosis, type 1 10.1
13 pseudoretinitis pigmentosa 10.0 C2 MNX1
14 ovarian cyst 9.9
15 marfan syndrome 9.9
16 encephalocele 9.9
17 meningoencephalocele 9.9
18 dandy-walker syndrome 9.9
19 dermoid cyst 9.9
20 teratoma 9.8
21 cerebritis 9.8
22 macrotrabecular hepatoblastoma 9.8 C2 HSF4
23 arachnoiditis 9.7
24 neurofibroma 9.7
25 myelomeningocele 9.7
26 arachnoid cysts 9.7
27 diastematomyelia 9.7
28 hydrocephalus 9.7
29 bacterial meningitis 9.7
30 tethered cord syndrome 9.6
31 amniotic band syndrome 9.6
32 aneurysm 9.6
33 intracranial hypotension 9.6
34 cerebrospinal fluid leak 9.6
35 chiari malformation 9.6
36 syncope 9.6
37 constipation 9.6
38 klippel-feil syndrome 9.6
39 pharyngitis 9.6
40 imperforate anus 9.6
41 mediastinitis 9.6
42 choroiditis 9.6
43 spinal intradural arachnoid cysts 9.6
44 cauda equina syndrome 9.6
45 syringomyelia 9.6
46 shwachman-diamond type metaphyseal dysplasia 9.6 MNX1 SATB2
47 hepatic veno-occlusive disease 9.5 MNX1 SATB2
48 hajdu-cheney syndrome 9.5
49 mononeuropathy 9.5
50 tarlov cysts 9.5

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.35 MNX1 NF1 NOTCH3 SATB2 VANGL1
2 skeleton MP:0005390 9.02 MNX1 NF1 NOTCH3 SATB2 VANGL1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

id Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

39
Spinal Cord, Bone, Eye, Skin, Uterus, Heart, Breast

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 568)
id Title Authors Year
1
Stabilization of Visual Function After Optic Nerve Sheath Fenestration for Optic Nerve Meningocele. ( 28538611 )
2017
2
Pulsatile Proptosis due to Intraorbital Meningocele. ( 28674516 )
2017
3
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. ( 28746249 )
2017
4
Anterior sacral meningocele presenting as intracystic bleeding. ( 28523383 )
2017
5
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
6
Encephalocele development from a congenital meningocele: case report. ( 28885087 )
2017
7
Meningocele manquAc: a comprehensive review of this enigmatic finding in occult spinal dysraphism. ( 28620735 )
2017
8
Multidisciplinary surgical treatment of presacral meningocele and teratoma in an adult with Currarino triad. ( 28584680 )
2017
9
Unusual Presentation of Intrasacral Meningocele: A Case Report and Overview. ( 28553381 )
2017
10
Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. ( 28247440 )
2017
11
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report. ( 28621617 )
2017
12
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
13
Meningocele manquAc. ( 28478392 )
2017
14
Correlation of Oxidative Damage with Pro-Inflammatory Markers (IL-6, TNF-I+) in Meningocele. ( 27042444 )
2016
15
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
16
Squamous cell carcinoma arising from neglected meningocele. ( 28194302 )
2016
17
OPTIC NERVE MENINGOCELE SIMULATING EXTRAOCULAR EXTENSION OF CHOROIDAL MELANOMA. ( 27617394 )
2016
18
Differential diagnosis of anterior sacral meningocele during the evaluation of post-hysterectomy pelvic collections. ( 27403027 )
2016
19
Neck swelling due to skull base (pseudo)meningocele protruding through a congenital skull base bone defect: a case report. ( 27830332 )
2016
20
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
21
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
22
Neurosurgical management in lateral meningocele syndrome: case report. ( 27911244 )
2016
23
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016
24
Nasal meningocele. ( 28039144 )
2016
25
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
26
Spina Bifida, Meningomyelocele, and Meningocele. ( 26725976 )
2016
27
Meningocele and Meningoencephalocele of the Lateral Wall of the Sphenoid Sinus. ( 26732955 )
2016
28
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
29
Type I Cutaneous Meningioma (Rudimentary Meningocele) With Intradural Attachment to the Phylum Terminale. ( 27828803 )
2016
30
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
31
Giant Intrathoracic Meningocele and Breast Cancer in a Neurofibromatosis Type I Patient. ( 27847582 )
2016
32
Currarino Syndrome and the Effect of a Large Anterior Sacral Meningocele on Distal Colostogram in an Anorectal Malformation. ( 27761181 )
2016
33
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
34
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
35
Dizziness caused by meningocele-associated intracranial hypotension in neurofibromatosis type 1. ( 27765822 )
2016
36
Thoracic meningocele in lumbo-costo-vertebral syndrome in a child: possible enlargement with repeated motion by anchoring to the diaphragm. ( 27058456 )
2016
37
Lateral meningocele (Lehman) syndrome: A child with a novel NOTCH3 mutation. ( 26754023 )
2016
38
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
39
Successful management of a giant anterior sacral meningocele with an endoscopic cutting stapler: case report. ( 26745349 )
2016
40
Congenital Jejunal Tubular Duplication in a Patient with a Congenital Thoracic Meningocele. ( 26601745 )
2015
41
Cervical vertebral fusion with anterior meningocele. ( 25923673 )
2015
42
Anesthetic management of a newborn with occipital meningocele for magnetic resonance imaging. ( 26417133 )
2015
43
Collaborative treatment of huge intrathoracic meningoceles associated with neurofibromatosis type 1: a case report. ( 26556010 )
2015
44
Two cases of meningocele and meningoencephalocele in Jeju native pigs. ( 25889174 )
2015
45
IMAGES IN CLINICAL MEDICINE. Cervical Meningocele. ( 26200992 )
2015
46
Anterior Sacral Meningocele Masquerading as an Ovarian Cyst: A Rare Clinical Presentation Associated with Marfan Syndrome. ( 26236457 )
2015
47
Is repair of the protruded meninges sufficient for treatment of meningocele? ( 26298824 )
2015
48
Congenital Jejunal Tubular Duplication in a Patient with a Congenital Thoracic Meningocele. ( 26350649 )
2015
49
True Cervicothoracic Meningocele: A Rare and Benign Condition. ( 26788266 )
2015
50
Lateral meningocele with asymmetric canal stenosis: A case study. ( 25561891 )
2015

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.43 HSF4 MNX1 SATB2
2 pigmentation GO:0043473 9.16 NF1 VANGL1
3 eye development GO:0001654 8.96 ADAMTS18 HSF4
4 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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