MCID: MNN020
MIFTS: 47

Meningococcal Infection malady

Infectious category

Summaries for Meningococcal Infection

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Meningococci are a type of bacteria that cause serious infections. the most common infection is meningitis, which is an inflammation of the thin tissue that surrounds the brain and spinal cord. meningococci can also cause other problems, including a serious bloodstream infection called sepsis. meningococcal infections can spread from person to person. risk factors include age - it is more common in infants, teens, and young adults living in close quarters, such as in college dorms or military settings certain medical conditions, such as not having a spleen travel to areas where meningococcal disease is common in its early stages, you may have flu-like symptoms and a stiff neck. but the disease can progress quickly and can be fatal. early diagnosis and treatment are extremely important. lab tests on your blood and cerebrospinal fluid can tell if you have it. treatment is with antibiotics. since the infection spreads from person to person, family members may also need to be treated. a vaccine can prevent meningococcal infections.

MalaCards: Meningococcal Infection, also known as meningococcal infections, is related to neisseria meningitidis infection and septic shock. An important gene associated with Meningococcal Infection is CFP (complement factor properdin), and among its related pathways are Renin-angiotensin system and Activation of C3 and C5. The compounds pge2 and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and cortex, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Wikipedia:64 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Aliases & Classifications for Meningococcal Infection

Sources:
43NIH Rare Diseases, 34MedlinePlus, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

meningococcal infection 43
meningococcal infections 34 61


External Ids:

ICD1025 A39

Related Diseases for Meningococcal Infection

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Meningococcal Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1neisseria meningitidis infection30.8TLR4, IL1RN, ROM1, CFP
2septic shock30.2TLR4, TNFRSF1B, IL18R1, IL1RN, CFP, ADRB2
3thrombocytopenia30.0TLR4, CFH
4hepatitis c30.0GSR, TNFRSF1B, TLR4
5arthritis30.0TLR4, TNFRSF1B, AGTR1, IL18R1, IL1RN, ADRB2
6systemic lupus erythematosus30.0TLR4, TNFRSF1B, IL1RN, CFH, CFP, ADRB1
7meningococcal meningitis10.5
8waterhouse-friderichsen syndrome10.3
9waterhouse–friderichsen syndrome10.3
10complement component deficiency10.3
11bacterial meningitis10.2
12meningococcemia10.2
13properdin deficiency10.2
14complement factor i deficiency10.0
15acquired immunodeficiency syndrome10.0
16septic arthritis10.0
17cerebral malaria10.0
18n syndrome10.0
19complement factor h deficiency10.0
20complement factor d deficiency10.0
21meningitis10.0CFP
22lupus erythematosus10.0CFP
23complement deficiency10.0CFP
24thromboembolism10.0G6PD
25amyotrophic lateral sclerosis10.0GSR
26peritonitis10.0IL18R1
27vasculitis10.0TNFRSF1B
28periodontitis10.0TLR4
29pulmonary disease, chronic obstructive10.0ADRB2
30hepatitis10.0TTR
31mitral valve prolapse10.0AGTR1
32viral hepatitis10.0G6PD
33neuropathy10.0TTR
34nephrotic syndrome10.0AGT
35hyperhomocysteinemia10.0TTR
36friedreich ataxia10.0GSR
37age related macular degeneration10.0CFH
38adult-onset still's disease10.0TNFRSF1B
39blindness10.0CFH
40bronchiolitis10.0TLR4
41nephritis10.0IL1RN, CFP
42wilson disease10.0G6PD
43guillain-barre syndrome10.0TNFRSF1B
44dilated cardiomyopathy10.0ADRB2, ADRB1
45ankylosing spondylitis10.0TNFRSF1B
46chagas disease10.0GSR, ADRB1
47ovarian cancer10.0AGTR1
48hepatitis b10.0TLR4, GSR
49myocarditis10.0ADRB1, TNFRSF1B
50mastitis10.0TLR4

Graphical network of the top 20 diseases related to Meningococcal Infection:



Diseases related to meningococcal infection

Clinical Features for Meningococcal Infection

Drugs & Therapeutics for Meningococcal Infection

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Meningococcal Infection

Drug clinical trials:

Search ClinicalTrials for Meningococcal Infection

Search NIH Clinical Center for Meningococcal Infection

Search CenterWatch for Meningococcal Infection

Genetic Tests for Meningococcal Infection

Anatomical Context for Meningococcal Infection

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Meningococcal Infection:

33
Spleen, Brain, Cortex, Spinal cord, Thyroid, Skin, Monocytes, T cells, B cells, Adrenal cortex

Animal Models for Meningococcal Infection or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Meningococcal Infection

Sources:
51PubMed
See all sources

Articles related to Meningococcal Infection:

(show top 50)    (show all 241)
idTitleAuthorsYear
1
Severe meningococcal infection: a review of epidemiology, diagnosis, and management. (23830646)
2013
2
Patterns of meningococcal infection in Sudan with emergence of Neisseria meningitidis serogroup W135. (24313147)
2013
3
Bilateral facial palsy in a young patient after meningococcal meningitis, associated to herpetic infection. (19722059)
2009
4
Risk of transmitting meningococcal infection by transient contact on aircraft and other transport. (19296869)
2009
5
Prognostic utility of the semi-quantitative procalcitonin test, neutrophil count and C-reactive protein in meningococcal infection in children. (16249930)
2006
6
Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections. (16527897)
2006
7
Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock. (15193387)
2004
8
Unusual sequelae of meningococcal infection: a case report of hepatic dysfunction, protracted neurological complications and late cutaneous manifestations associated with serogroup y. (12643869)
2003
9
Outbreak of group C meningococcal infection affecting two preschool nurseries. (11014030)
2000
10
Lack of immunity in university students before an outbreak of serogroup C meningococcal infection. (10720549)
2000
11
Risk of meningococcal infection in college students. (10349894)
1999
12
Plasma patterns of tumor necrosis factor-alpha (TNF) and TNF soluble receptors during acute meningococcal infections and the effect of plasma exchange. (9564476)
1998
13
Changing patterns of antibiotic sensitivity and resistance during an outbreak of meningococcal infection in Jos, Nigeria. (9819486)
1998
14
Meningococcal infection in Scotland, 1995 to 1997. (12631797)
1997
15
Clinical predictors of epidemic outcome in meningococcal infection in Jos, Nigeria. (9491173)
1997
16
A college outbreak of group C meningococcal infection: how widely should investigation and prophylaxis extend? (9029871)
1997
17
Meningococcal infection in Africa. (8680504)
1996
18
Meningococcal infection. (8682637)
1996
19
The enzyme activity and pyruvate, lactate and 2,3-DPG levels in the erythrocytes of patients with severe forms of meningococcal infection and suppurative meningitis]. (8771662)
1996
20
Community-sampling of blood in suspected meningococcal infection. (8874480)
1996
21
Initial management of suspected meningococcal infection. Parenteral benzylpenicillin is vital. (7819968)
1994
22
Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections. (8277177)
1994
23
Disseminated meningococcal infection in HIV-seropositive patients. (8442922)
1993
24
Chemoprophylaxis against meningococcal infection. (8336592)
1993
25
Disseminated gonococcal infection vs. meningococcal infection. (8342473)
1993
26
Meningococcal infection: diagnostic and therapeutic pitfalls. (1530701)
1992
27
Amputation for gangrene of the limbs following severe meningococcal infection. (1377255)
1992
28
Fatal intrauterine meningococcal infection. (1749700)
1991
29
Preventing meningococcal infection. (2131249)
1990
30
A case of indolent meningococcal infection. (2721093)
1989
31
Monoclonal antibodies to the rough lipopolysaccharide of Neisseria meningitidis protect infant rats from meningococcal infection. (3134492)
1988
32
Meningococcal infection in children. (3170153)
1988
33
Group B meningococcal infection in children during an epidemic in Cape Town, South Africa. (2439004)
1987
34
Deaths from meningococcal infection in Lanarkshire 1984-1986. (3122262)
1987
35
Control of meningococcal infection. (3786647)
1986
36
Gangrene requiring amputation in meningococcal infection. (3972544)
1985
37
Role of electroencephalography in assessment of patients after meningococcal infection. (6521867)
1984
38
Experimental meningococcal infection in neonatal mice: differences in virulence between strains isolated from human cases and carriers. (6437654)
1984
39
Recurrent meningococcal infections associated with a functional deficiency of the C8 component of human complement. (6771072)
1980
40
Letter: Concomitant hepatitis B and meningococcal infection. (946197)
1976
41
Letter: Chemophrophylaxis of meningococcal infection. (46003)
1975
42
Immunoprophylaxis of meningococcal infection. (4204814)
1974
43
Disseminated intravascular coagulation in meningococcal infection. (5023490)
1972
44
Thrombocytopenia and bleeding complications in severe cases of meningococcal infection treated with heparin, dextran 70 and chlorpromazine. (4485601)
1972
45
Attempted prophylaxis against meningococcal infection using intramuscular penicillin. (4965740)
1967
46
Immunity in experimental meningococcal infection. (4957891)
1966
47
Meningococcemia and meningococcal infections: review of 45 cases. (13945640)
1963
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Pathological changes in adrenal cortex of mouse during experimental meningococcal infection. (14844310)
1951
50
INVESTIGATIONS OF MENINGOCOCCAL INFECTION. II. IMMUNOLOGICAL ASPECTS. (16695016)
1943

Genetic Variations for Meningococcal Infection

Expression for genes affiliated with Meningococcal Infection

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Meningococcal Infection

Search GEO for disease gene expression data for Meningococcal Infection.

Pathways for genes affiliated with Meningococcal Infection

Sources:
30KEGG, 54Reactome, 52QIAGEN, 56SinoBiological, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Meningococcal Infection

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Meningococcal Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1pge24510.6ADRB2
2norepinephrine45 11 2412.4TTR, ADRB1
3nadph45 2411.3TLR4, G6PD
4uric acid45 2411.2G6PD, TTR
5Pirbuterol1110.2ADRB2, ADRB1
6Levobunolol1110.1ADRB2, ADRB1
7Metipranolol1110.1ADRB2, ADRB1
8lk 204-5452910.0ADRB1, ADRB2
9nip2910.0ADRB1, ADRB2
10pcbs4510.0IL18R1, CPB2, TTR
11glutamate4510.0AGTR1, ADRB2, ADRB1
12nihp299.9ADRB1, ADRB2
13polyethylene glycol459.8TNFRSF1B, IL18R1, IL1RN, G6PD
14atenolol45 29 50 11 2413.8ADRB2, ADRB1, AGT, AGTR1
15infliximab45 50 1111.7IL1RN, TLR4, TNFRSF1B, IL18R1
16aspartate459.7ADRB2, ADRB1, TTR, G6PD
17cicloprolol299.7ADRB1, ADRB2
18neopterin459.7IL1RN, IL18R1, TNFRSF1B, TTR
19heparin45 29 11 2412.6CFP, IL18R1, AGT, CPB2, IL1RN
20cyclosporin a45 29 6011.6TTR, CFH, TNFRSF1B, IL18R1
21chloroquine45 2 50 29 1113.6GSR, IL1RN, TLR4, TNFRSF1B, G6PD
22superoxide45 2410.6CFP, AGT, G6PD, TNFRSF1B, AGTR1
23oxygen45 2410.5IL18R1, ADRB2, ADRB1, AGT, TNFRSF1B
24ascorbic acid45 2410.5GSR, CFP, IL1RN, G6PD, TTR
25n acetylcysteine459.3G6PD, TLR4, AGTR1, AGT, GSR
26vitamin-e459.3TTR, GSR, TNFRSF1B, IL1RN, AGTR1, G6PD
27dexamethasone45 50 29 1112.2CFH, ADRB1, CFD, TNFRSF1B, TLR4, AGT
28lactate459.2TLR4, G6PD, TTR, ADRB2, GSR, IL1RN
29aspirin45 50 29 2412.2TLR4, G6PD, IL1RN, ADRB2, AGTR1, TTR
30sodium45 2410.1TLR4, ADD1, AGT, TNFRSF1B, ADRB1, AGTR1
31cisplatin45 50 60 1111.9IL18R1, G6PD, GSR, CFH, TNFRSF1B, AGTR1
32h2o2458.9G6PD, IL1RN, GSR, AGTR1, AGT, TNFRSF1B
33epinephrine45 11 2410.8IL1RN, TTR, ADRB1, GSR, ADRB2, AGT
34glucose458.7ADD1, ADRB1, CFD, IL18R1, AGT, AGTR1
35estrogen458.7TNFRSF1B, AGTR1, IL18R1, IL1RN, TTR, ADRB2
36vegf458.6TNFRSF1B, CFD, TLR4, AGT, IL1RN, AGTR1
37retinoic acid45 249.6CFD, IL1RN, IL18R1, TNFRSF1B, TLR4, CFH
38creatinine458.6G6PD, AGTR1, AGT, IL1RN, CFD, ADRB2
39zinc45 249.5TLR4, CFH, TTR, ADRB2, CPB2, IL18R1
40adenylate458.5IL1RN, AGT, IL18R1, GSR, G6PD, TTR
41arginine458.5ADRB1, CPB2, GSR, ADRB2, TTR, IL18R1
42nitric oxide45 11 2410.4ADD1, ADRB1, IL18R1, AGT, AGTR1, TNFRSF1B
43fibrinogen458.4TLR4, IL1RN, TNFRSF1B, AGTR1, AGT, CPB2
44alanine458.3GSR, IL1RN, AGTR1, TLR4, IL18R1, TTR
45serine458.2ADD1, TLR4, ADRB2, ADRB1, IL1RN, IL18R1
46calcium45 50 11 2411.1TNFRSF1B, IL1RN, IL18R1, ADD1, AGT, AGTR1
47cholesterol45 29 11 2411.0CFH, TTR, CPB2, ADD1, ROM1, IL1RN
48tyrosine458.0AGTR1, TNFRSF1B, AGT, IL18R1, IL1RN, CFH
49lipid457.9G6PD, AGTR1, AGT, IL18R1, IL1RN, GSR
50cysteine457.6IL18R1, IL1RN, ROM1, TTR, CFH, TLR4

GO Terms for genes affiliated with Meningococcal Infection

Sources:
16Gene Ontology
See all sources

Cellular components related to Meningococcal Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane attack complexGO:0055799.6C8A, C8B, C7
2extracellular regionGO:0055768.2CFP, CFH, CFD, TTR, AGT, TNFRSF1B
3extracellular spaceGO:0056158.1C8A, CPB2, CFP, CFH, CFD, TTR

Biological processes related to Meningococcal Infection according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1heat generationGO:03164910.3ADRB1, ADRB2
2vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.3ADRB1, ADRB2
3cytolysisGO:01983510.3C7, C8B, C8A
4negative regulation of smooth muscle contractionGO:04598610.2ADRB1, ADRB2
5diet induced thermogenesisGO:00202410.1ADRB1, ADRB2
6positive regulation of NAD(P)H oxidase activityGO:03386410.1AGTR1, AGT
7complement activation, classical pathwayGO:00695810.1C7, C8B, C8A
8regulation of blood vessel size by renin-angiotensinGO:00203410.1AGTR1, AGT
9regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
10renin-angiotensin regulation of aldosterone productionGO:00201810.0AGTR1, AGT
11regulation of vasodilationGO:04231210.0AGTR1, ADRB2
12response to coldGO:00940910.0ADRB2, ADRB1, AGT
13positive regulation of cholesterol esterificationGO:01087310.0AGTR1, AGT
14low-density lipoprotein particle remodelingGO:0343749.8AGTR1, AGT
15positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
16negative regulation of multicellular organism growthGO:0400159.7ADRB2, ADRB1
17regulation of complement activationGO:0304499.7C8A, C8B, CFH, CFP, C7
18positive regulation of cellular protein metabolic processGO:0322709.7AGT, AGTR1
19positive regulation of inflammatory responseGO:0507299.7AGT, AGTR1, TLR4
20complement activation, alternative pathwayGO:0069579.6C7, CFP, CFH, CFD, C8B, C8A
21complement activationGO:0069569.5C8A, C8B, CFD, CFH, CFP, C7
22innate immune responseGO:0450879.2TLR4, C8A, C8B, CFD, CFH, CFP
23immune responseGO:0069559.2TLR4, C8A, C8B, TNFRSF1B, IL18R1, IL1RN

Molecular functions related to Meningococcal Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1norepinephrine bindingGO:05138010.0ADRB2, ADRB1
2acetyltransferase activator activityGO:0106989.5AGT, AGTR1

Products for genes affiliated with Meningococcal Infection

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningococcal Infection

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet