MCID: MNN020
MIFTS: 40

Meningococcal Infection malady

Infectious diseases category

Summaries for Meningococcal Infection

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Meningococci are a type of bacteria that cause serious infections. the most common infection is meningitis, which is an inflammation of the thin tissue that surrounds the brain and spinal cord. meningococci can also cause other problems, including a serious bloodstream infection called sepsis. meningococcal infections can spread from person to person. risk factors include age - it is more common in infants, teens, and young adults living in close quarters, such as in college dorms or military settings certain medical conditions, such as not having a spleen travel to areas where meningococcal disease is common in its early stages, you may have flu-like symptoms and a stiff neck. but the disease can progress quickly and can be fatal. early diagnosis and treatment are extremely important. lab tests on your blood and cerebrospinal fluid can tell if you have it. treatment is with antibiotics. since the infection spreads from person to person, family members may also need to be treated. a vaccine can prevent meningococcal infections.

MalaCards: Meningococcal Infection, also known as meningococcal infections, is related to meningitis and complement deficiency. An important gene associated with Meningococcal Infection is CFP (complement factor properdin), and among its related pathways are Renin-angiotensin system and Activation of C3 and C5. The compounds pge2 and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and spinal cord, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Wikipedia:63 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Aliases & Classifications for Meningococcal Infection

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

meningococcal infection 42
meningococcal infections 33 60


External Ids:

ICD1025 A39

Related Diseases for Meningococcal Infection

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Meningococcal Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis30.7CFP
2complement deficiency30.7CFP
3neisseria meningitidis infection30.3TLR4, IL1RN, ROM1, CFP
4hepatitis30.2TTR
5malaria30.2GSR, CFP, G6PD, IL18R1
6lupus erythematosus30.0CFP
7hepatitis b30.0GSR, TLR4
8myocarditis30.0TNFRSF1B, ADRB1
9thrombocytopenia30.0CFH, TLR4
10hypertension30.0AGTR1, AGT, ADRB2, ADD1, ADRB1
11arthritis29.9ADRB2, TLR4, TNFRSF1B, IL18R1, IL1RN, AGTR1
12systemic lupus erythematosus29.9CFH, IL1RN, TNFRSF1B, CFP, TLR4, ADRB1
13myocardial infarction29.9ADD1, ADRB2, ADRB1, CFH, GSR, AGTR1
14waterhouse-friderichsen syndrome10.3
15disseminated intravascular coagulation10.3
16pericarditis10.2
17bacterial meningitis10.1
18cerebritis10.0
19pharyngitis10.0
20acquired immunodeficiency syndrome10.0
21septic arthritis10.0
22cerebral malaria10.0
23hepatitis a10.0
24iridocyclitis10.0
25thyroiditis10.0
26waterhouse–friderichsen syndrome10.0
27complement factor h deficiency10.0
28meningococcal meningitis10.0
29thromboembolism10.0G6PD
30amyotrophic lateral sclerosis10.0GSR
31peritonitis10.0IL18R1
32vasculitis10.0TNFRSF1B
33periodontitis10.0TLR4
34pulmonary disease, chronic obstructive10.0ADRB2
35mitral valve prolapse10.0AGTR1
36viral hepatitis10.0G6PD
37neuropathy10.0TTR
38nephrotic syndrome10.0AGT
39hyperhomocysteinemia10.0TTR
40friedreich ataxia10.0GSR
41age related macular degeneration10.0CFH
42adult-onset still's disease10.0TNFRSF1B
43blindness10.0CFH
44bronchiolitis10.0TLR4
45nephritis10.0IL1RN, CFP
46wilson disease10.0G6PD
47guillain-barre syndrome10.0TNFRSF1B
48dilated cardiomyopathy10.0ADRB2, ADRB1
49ankylosing spondylitis10.0TNFRSF1B
50chagas disease10.0ADRB1, GSR

Graphical network of the top 20 diseases related to Meningococcal Infection:



Diseases related to meningococcal infection

Clinical Features for Meningococcal Infection

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Drugs & Therapeutics for Meningococcal Infection

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Meningococcal Infection

Drug clinical trials:

Search ClinicalTrials for Meningococcal Infection

Search NIH Clinical Center for Meningococcal Infection

Search CenterWatch for Meningococcal Infection

Genetic Tests for Meningococcal Infection

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Anatomical Context for Meningococcal Infection

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Sources:
32MalaCards
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MalaCards organs/tissues related to Meningococcal Infection:

32
Spleen, Brain, Spinal cord, Testes

Animal Models for Meningococcal Infection or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Meningococcal Infection:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3C8B, TNFRSF1B, G6PD, IL1RN, CFH, ADRB2
2MP:00053678.3TLR4, TNFRSF1B, AGTR1, AGT, CFH, CPB2
3MP:00053877.5TLR4, TNFRSF1B, AGTR1, AGT, IL18R1, IL1RN
4MP:00107687.4AGTR1, G6PD, TNFRSF1B, TLR4, AGT, IL1RN
5MP:00053857.4GSR, TLR4, TNFRSF1B, G6PD, AGTR1, AGT
6MP:00053767.0AGT, AGTR1, G6PD, TNFRSF1B, TLR4, IL1RN

Publications for Meningococcal Infection

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Genetic Variations for Meningococcal Infection

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Expression for genes affiliated with Meningococcal Infection

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningococcal Infection

Search GEO for disease gene expression data for Meningococcal Infection.

Pathways for genes affiliated with Meningococcal Infection

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 55SinoBiological, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Meningococcal Infection

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Meningococcal Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1pge24410.6ADRB2
2norepinephrine44 11 2412.4TTR, ADRB1
3nadph44 2411.3TLR4, G6PD
4uric acid44 2411.2G6PD, TTR
5Pirbuterol1110.2ADRB2, ADRB1
6Levobunolol1110.1ADRB2, ADRB1
7Metipranolol1110.1ADRB2, ADRB1
8lk 204-5452810.0ADRB1, ADRB2
9nip2810.0ADRB1, ADRB2
10pcbs4410.0IL18R1, CPB2, TTR
11glutamate4410.0AGTR1, ADRB2, ADRB1
12nihp289.9ADRB1, ADRB2
13polyethylene glycol449.8TNFRSF1B, IL18R1, IL1RN, G6PD
14atenolol44 28 49 11 2413.8ADRB2, ADRB1, AGT, AGTR1
15infliximab44 49 1111.7IL1RN, TLR4, TNFRSF1B, IL18R1
16aspartate449.7ADRB2, ADRB1, TTR, G6PD
17cicloprolol289.7ADRB1, ADRB2
18neopterin449.7IL1RN, IL18R1, TNFRSF1B, TTR
19heparin44 28 11 2412.6CFP, IL18R1, AGT, CPB2, IL1RN
20cyclosporin a44 28 5911.6TTR, CFH, TNFRSF1B, IL18R1
21chloroquine44 2 49 28 1113.6GSR, IL1RN, TLR4, TNFRSF1B, G6PD
22superoxide44 2410.6CFP, AGT, G6PD, TNFRSF1B, AGTR1
23oxygen44 2410.5IL18R1, ADRB2, ADRB1, AGT, TNFRSF1B
24ascorbic acid44 2410.5GSR, CFP, IL1RN, G6PD, TTR
25n acetylcysteine449.3G6PD, TLR4, AGTR1, AGT, GSR
26vitamin-e449.3TTR, GSR, TNFRSF1B, IL1RN, AGTR1, G6PD
27dexamethasone44 49 28 1112.2CFH, ADRB1, CFD, TNFRSF1B, TLR4, AGT
28lactate449.2TLR4, G6PD, TTR, ADRB2, GSR, IL1RN
29aspirin44 49 28 2412.2TLR4, G6PD, IL1RN, ADRB2, AGTR1, TTR
30sodium44 2410.1TLR4, ADD1, AGT, TNFRSF1B, ADRB1, AGTR1
31cisplatin44 49 59 1111.9IL18R1, G6PD, GSR, CFH, TNFRSF1B, AGTR1
32h2o2448.9G6PD, IL1RN, GSR, AGTR1, AGT, TNFRSF1B
33epinephrine44 11 2410.8IL1RN, TTR, ADRB1, GSR, ADRB2, AGT
34glucose448.7ADD1, ADRB1, CFD, IL18R1, AGT, AGTR1
35estrogen448.7TNFRSF1B, AGTR1, IL18R1, IL1RN, TTR, ADRB2
36vegf448.6TNFRSF1B, CFD, TLR4, AGT, IL1RN, AGTR1
37retinoic acid44 249.6CFD, IL1RN, IL18R1, TNFRSF1B, TLR4, CFH
38creatinine448.6G6PD, AGTR1, AGT, IL1RN, CFD, ADRB2
39zinc44 249.5TLR4, CFH, TTR, ADRB2, CPB2, IL18R1
40adenylate448.5IL1RN, AGT, IL18R1, GSR, G6PD, TTR
41arginine448.5ADRB1, CPB2, GSR, ADRB2, TTR, IL18R1
42nitric oxide44 11 2410.4ADD1, ADRB1, IL18R1, AGT, AGTR1, TNFRSF1B
43fibrinogen448.4TLR4, IL1RN, TNFRSF1B, AGTR1, AGT, CPB2
44alanine448.3GSR, IL1RN, AGTR1, TLR4, IL18R1, TTR
45serine448.2ADD1, TLR4, ADRB2, ADRB1, IL1RN, IL18R1
46calcium44 49 11 2411.1TNFRSF1B, IL1RN, IL18R1, ADD1, AGT, AGTR1
47cholesterol44 28 11 2411.0CFH, TTR, CPB2, ADD1, ROM1, IL1RN
48tyrosine448.0AGTR1, TNFRSF1B, AGT, IL18R1, IL1RN, CFH
49lipid447.9G6PD, AGTR1, AGT, IL18R1, IL1RN, GSR
50cysteine447.6IL18R1, IL1RN, ROM1, TTR, CFH, TLR4

GO Terms for genes affiliated with Meningococcal Infection

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16Gene Ontology
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Cellular components related to Meningococcal Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane attack complexGO:0055799.6C8A, C8B, C7
2extracellular regionGO:0055768.2C8B, TNFRSF1B, AGT, TTR, CFD, CFH
3extracellular spaceGO:0056158.1CPB2, C8A, C8B, AGT, IL1RN, TTR

Biological processes related to Meningococcal Infection according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1heat generationGO:03164910.3ADRB1, ADRB2
2vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.3ADRB1, ADRB2
3cytolysisGO:01983510.3C7, C8B, C8A
4negative regulation of smooth muscle contractionGO:04598610.2ADRB1, ADRB2
5diet induced thermogenesisGO:00202410.1ADRB1, ADRB2
6positive regulation of NAD(P)H oxidase activityGO:03386410.1AGTR1, AGT
7complement activation, classical pathwayGO:00695810.1C7, C8B, C8A
8regulation of blood vessel size by renin-angiotensinGO:00203410.1AGTR1, AGT
9regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
10renin-angiotensin regulation of aldosterone productionGO:00201810.0AGTR1, AGT
11regulation of vasodilationGO:04231210.0AGTR1, ADRB2
12response to coldGO:00940910.0ADRB2, ADRB1, AGT
13positive regulation of cholesterol esterificationGO:01087310.0AGTR1, AGT
14low-density lipoprotein particle remodelingGO:0343749.8AGTR1, AGT
15positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
16negative regulation of multicellular organism growthGO:0400159.7ADRB2, ADRB1
17regulation of complement activationGO:0304499.7C8A, C8B, CFH, CFP, C7
18positive regulation of cellular protein metabolic processGO:0322709.7AGT, AGTR1
19positive regulation of inflammatory responseGO:0507299.7AGT, AGTR1, TLR4
20complement activation, alternative pathwayGO:0069579.6C7, CFP, CFH, CFD, C8B, C8A
21complement activationGO:0069569.5C8A, C8B, CFD, CFH, CFP, C7
22innate immune responseGO:0450879.2TLR4, C8A, C8B, CFD, CFH, CFP
23immune responseGO:0069559.2TLR4, C8A, C8B, TNFRSF1B, IL18R1, IL1RN

Molecular functions related to Meningococcal Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1norepinephrine bindingGO:05138010.0ADRB2, ADRB1
2acetyltransferase activator activityGO:0106989.5AGT, AGTR1

Products for genes affiliated with Meningococcal Infection

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningococcal Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet