MCID: MNN021
MIFTS: 38

Meningococcemia malady

Category: Rare diseases

Aliases & Classifications for Meningococcemia

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Aliases & Descriptions for Meningococcemia:

Name: Meningococcemia 48 50 68

Classifications:



Summaries for Meningococcemia

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Wikipedia:71 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to c4b deficiency and bacteremia. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways are Interleukin-1 processing and Cytokines and Inflammatory Response. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system.

Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1c4b deficiency30.1CFP, MBL2
2bacteremia29.7BPI, MBL2
3myocardial infarction26.5CCL5, F5, IL1B, PROCR, SERPINC1, SERPINE1
4diabetic cataract10.6IL1A, IL1B
5gout susceptibility 410.6CFP, MBL2
6rectosigmoid junction neoplasm10.5IL1A, IL1B
7atrial septal defect coronary sinus10.5IL1B, MBL2
8inflammatory breast carcinoma10.5CFP, MBL2
9hypercementosis10.4IL1A, IL1RN
10gastric cancer risk after h. pylori infection10.4IL1B, IL1RN
11silo filler's disease10.4IL1B, IL1RN
12periodic paralyses10.4IL1A, IL1B
13liver disease10.4IL1A, IL1B
14pseudoretinitis pigmentosa10.4IL1A, IL1B
15non-secretory myeloma10.4IL1B, IL1RN
16congenital granular cell tumor10.4CFP, IL1A, MBL2
17onychocytic matricoma10.4F5, MBL2
18congenital stenosis of the inferior vena cava10.3F5, SERPINE1
19ameloblastic carcinoma10.3F5, SERPINE1
20unicentric castleman disease10.3F5, SERPINE1
21peri-anal fistula10.3IL1A, IL1B, IL1RN
22anaerobic meningitis10.3IL1A, IL1B, IL1RN
23histiocytoid hemangioma10.3IL1A, IL1B, IL1RN
24dmd-related dilated cardiomyopathy10.3PROC, SERPINC1
25pharyngitis10.3IL1RN, MBL2
26sinusitis10.2IL1A, IL1B, IL1RN
27cartilage disease10.2IL1B, SERPINC1
28lymphangioma10.2IL1A, IL1B, IL1RN
29pleomorphic lipoma10.2IL1A, IL1B, IL1RN
30xanthomatosis10.2IL1A, IL1B, IL1RN
31west nile fever10.2F5, SERPINE1
32palmoplantar keratosis10.2IL1A, IL1B, IL1RN
33chronic rhinitis10.2IL1A, IL1B, IL1RN
34warm antibody hemolytic anemia10.2IL1B, IL1RN, MBL2
35venezuelan hemorrhagic fever10.2SERPINC1, SERPINE1
36cinca syndrome10.2IL1B, IL1RN
37retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.2F5, SERPINE1
38hypertensive heart disease10.2SERPINC1, SERPINE1
39meningitis10.2
40lateral cystocele10.2SERPINC1, SERPINE1
41posterolateral myocardial infarction10.2SERPINC1, SERPINE1
42purpura10.1
43chromophobe adenoma10.1SERPINE1, THBD
44catatrichy10.1F5, PROC, SERPINE1
45subcortical arteriosclerotic encephalopathy10.1F5, SERPINC1
46hepatic fibrosis renal cysts mental retardation10.1F5, SERPINC1
47charcot-marie-tooth disease10.1F5, IL1B, MBL2
48thrombophilia due to thrombin defect10.1F5, SERPINC1
49childhood central nervous system germinoma10.1F5, THBD
50purpura fulminans10.1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms & Phenotypes for Meningococcemia

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GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00362-A8.3MBL2, PROC, SERPINC1, SERPINE1, THBD

MGI Mouse Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.7CFP, F5, IL1A, IL1B, IL1RN, PROC
2MP:00053976.8CCL5, IL1A, IL1B, IL1RN, MBL2, PROC
3MP:00053766.8CFP, F5, IL1A, IL1B, IL1RN, MBL2
4MP:00053876.4CCL5, CFP, IL1A, IL1B, IL1RN, MBL2

Drugs & Therapeutics for Meningococcemia

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Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 3, Phase 26428
2
Hydrocortisoneapproved, vet_approvedPhase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
3
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
4Hydrocortisone acetatePhase 2640
5Hydrocortisone-17-butyratePhase 2318
6Hydrocortisone 17-butyrate 21-propionatePhase 2640
7AntibodiesPhase 26045
8ImmunoglobulinsPhase 26045
9Cortisol succinatePhase 2640
10Anti-Inflammatory AgentsPhase 210355

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap VaccineCompletedNCT00777257Phase 4
2Immunology and Safety of Menactra® in Children in Saudi ArabiaCompletedNCT00539032Phase 3
3Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in AdolescentsCompletedNCT00777790Phase 2
4Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in ChildrenCompletedNCT00771849Phase 2
5Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26CompletedNCT00700713Phase 2
6Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate VaccineCompletedNCT00772070Phase 2
7Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot StudyCompletedNCT00732277Phase 2
8Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy AdultsTerminatedNCT00772629Phase 2
9Correlation Between Cytokines and the Severity of Meningococcal DiseaseCompletedNCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

36
Skin, Bone, Testes, Atrioventricular node, Endothelial, Colon, Heart

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. (27481255)
2016
2
A rare case of chronic meningococcemia. (27728401)
2016
3
Meningococcemia in Adults: A Review of the Literature. (26984070)
2016
4
Chronic meningococcemia in an immunocompetent child. (27535891)
2016
5
Late Sequel of Meningococcemia: Skeletal Dysplasia. (26960252)
2016
6
Meningococcemia Presenting as a Myocardial Infarction. (26640720)
2015
7
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. (25970111)
2015
8
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. (25825033)
2015
9
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. (25420647)
2015
10
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. (24977653)
2014
11
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. (24577072)
2014
12
Meningococcemia: the pediatric orthopedic sequelae. (23622829)
2013
13
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. (23950664)
2013
14
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. (23061921)
2013
15
Purpura fulminans caused by meningococcemia in an infant. (23921694)
2013
16
Pathogenesis of meningococcemia. (23732856)
2013
17
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. (24047748)
2013
18
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. (23247497)
2012
19
Meningococcemia presenting as acute painful mononeuritis multiplex. (22100105)
2012
20
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. (22635194)
2012
21
A baby with meningococcemia and septic shock. (22689868)
2012
22
Rash in meningococcemia. (22892518)
2012
23
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. (22412064)
2012
24
Fatal meningococcemia. (23882342)
2011
25
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
26
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. (21075588)
2011
27
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. (20841592)
2010
28
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
29
Clinical images: Purpura fulminans caused by meningococcemia. (19858241)
2010
30
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. (20844162)
2010
31
Giant condyloma with demise secondary to meningococcemia in an infant boy. (19596116)
2009
32
Chronic meningococcemia in a 16-year-old boy: a case report. (19829911)
2009
33
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. (19620896)
2009
34
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. (18657927)
2009
35
Purpuric rash of meningococcemia. (18438796)
2008
36
Meningococcemia without meningitis in Japan. (18758132)
2008
37
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. (18559767)
2008
38
Meningococcemia. (19384501)
2008
39
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. (18516063)
2008
40
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
41
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. (17697137)
2007
42
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
43
Orchitis as a rare complication of meningococcemia in a young infant. (17387516)
2007
44
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
45
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
46
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. (17065145)
2006
47
Anterior uveitis and meningococcemia: a case report. (16766405)
2006
48
Diagnosing meningococcemia as a cause of sepsis. (15857559)
2005
49
Meningococcemia update vaccination and chemoprophylaxis. (16085964)
2005
50
Images in emergency medicine. Petechiae and purpura associated with meningococcemia. (15855959)
2005

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1A, IL1B
29.9IL1A, IL1B
39.5IL1A, IL1B, SERPINE1
49.5IL1A, IL1B, IL1RN
5
Show member pathways
9.5IL1A, IL1B, IL1RN
6
Show member pathways
9.2PROC, PROCR, THBD
79.0CCL5, IL1A, IL1B
89.0CCL5, IL1A, IL1B
99.0CCL5, IL1A, IL1B
109.0IL1A, IL1B, SERPINE1, THBD
11
Show member pathways
8.8CCL5, CFP, IL1A, IL1B
12
Show member pathways
8.5F5, PROC, SERPINC1, THBD
13
Show member pathways
7.7F5, PROC, PROCR, SERPINC1, SERPINE1, THBD
14
Show member pathways
7.3F5, MBL2, PROC, PROCR, SERPINC1, SERPINE1

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.5CCL5, CFP, F5, IL1A, IL1B, IL1RN
2extracellular spaceGO:00056155.4BPI, CCL5, CFP, F5, IL1A, IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.6IL1A, IL1B
2fever generationGO:000166010.6IL1A, IL1B
3positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
4positive regulation of mitotic nuclear divisionGO:004584010.3IL1A, IL1B
5negative regulation of coagulationGO:005081910.3PROC, PROCR
6positive regulation of monocyte chemotactic protein-1 productionGO:007163910.3IL1A, IL1B
7defense response to bacteriumGO:004274210.3BPI, CFP, MBL2
8positive regulation of interleukin-8 productionGO:003275710.3IL1B, SERPINE1
9negative regulation of fibrinolysisGO:005191810.2SERPINE1, THBD
10negative regulation of blood coagulationGO:00301959.9PROC, SERPINE1, THBD
11positive regulation of vascular endothelial growth factor productionGO:00105759.9IL1A, IL1B
12positive regulation of fever generationGO:00316229.9CCL5, IL1B
13positive regulation of monocyte chemotaxisGO:00900269.7CCL5, SERPINE1
14leukocyte migrationGO:00509009.5IL1B, PROC, PROCR, THBD
15immune responseGO:00069559.4BPI, CFP, IL1A, IL1RN, PROCR
16positive regulation of angiogenesisGO:00457669.2CCL5, IL1A, IL1B, SERPINE1
17blood coagulationGO:00075968.8F5, PROC, PROCR, SERPINC1, THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.9IL1A, IL1B
2cytokine activityGO:00051259.8IL1A, IL1B, IL1RN

Sources for Meningococcemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet