MCID: MNN021
MIFTS: 48

Meningococcemia malady

Rare diseases category

Summaries for Meningococcemia

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Wikipedia:65 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to purpura and disseminated intravascular coagulation. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cytokine Network. The compounds hirugen and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are embryogenesis and liver/biliary system.

Aliases & Classifications for Meningococcemia

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Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Meningococcemia, Aliases & Descriptions:

Name: Meningococcemia 43 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1purpura30.9SERPINC1
2disseminated intravascular coagulation30.5PROC, THBD, SERPINE1, LIF, F5, SERPINC1
3complement deficiency30.2LIF, CFP
4arthritis30.1IL1A, IL1B
5thrombocytopenia30.1SERPINC1, THBD, IL1A, F5
6tuberculosis29.9IL1B, BPI
7acute myocardial infarction29.9SERPINC1, SERPINE1, CCL5, THBD
8myocardial infarction29.9SERPINE1, SERPINC1, CCL5, F5, PROCR
9protein c deficiency29.8SERPINE1, CFP, THBD, F5, PROC, PROCR
10meningitis10.6
11waterhouse-friderichsen syndrome10.4
12meningococcal meningitis10.4
13myocarditis10.2
14c7 deficiency10.1
15hepatitis10.1
16osteonecrosis10.1
17septic arthritis10.1
18herpes simplex10.1
19ischemia10.1
20vasculitis10.1
21meningococcal infection10.1
22properdin deficiency10.1
23central retinal vein occlusion10.1F5
24sneddon syndrome10.1SERPINC1
25mediterranean spotted fever10.1THBD
26branch retinal artery occlusion10.1F5
27factor xi deficiency, autosomal recessive10.1F5
28intervertebral disc disease10.1IL1B
29periapical granuloma10.1CCL5
30eclampsia10.1THBD, SERPINC1
31gastric cancer risk after h. pylori infection10.0IL1RN
32post-thrombotic syndrome10.0F5, SERPINC1
33legg-calve-perthes disease10.0F5, SERPINC1
34placental abruption10.0SERPINC1, F5
35hypoprothrombinemia10.0F5, SERPINC1
36sagittal sinus thrombosis10.0F5, SERPINC1
37budd-chiari syndrome10.0SERPINC1, F5
38retinal vein occlusion10.0F5, SERPINC1
39blood protein disease10.0SERPINC1, F5
40intracranial thrombosis10.0F5, SERPINC1
41portal vein thrombosis10.0SERPINC1, F5
42thrombophilia due to antithrombin iii deficiency10.0F5, SERPINC1
43factor xii deficiency10.0F5, SERPINC1
44mastitis10.0IL1B
45factor vii deficiency10.0SERPINC1, F5
46hemophilia a10.0F5, SERPINC1
47otitis media10.0IL1B
48afibrinogenemia10.0CFP, F5
49carotid artery thrombosis10.0SERPINE1
50dengue shock syndrome10.0IL1RN, THBD

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

33
Skin, Bone, Testes, Heart, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

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MGI Mouse Phenotypes related to Meningococcemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F5, PROCR, LIF, SERPINC1, THBD
2MP:00053707.9THBD, SERPINE1, SERPINC1, LIF, PROC, F5
3MP:00107717.6THBD, SERPINE1, LIF, IL1RN, F5
4MP:00053787.2THBD, SERPINE1, LIF, PROC, PROCR, IL1RN
5MP:00107686.2SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
6MP:00053976.1LIF, SERPINC1, SERPINE1, THBD, PROC, PROCR
7MP:00053856.0SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
8MP:00053875.8IL1A, THBD, CFP, SERPINE1, SERPINC1, LIF
9MP:00053765.7SERPINC1, SERPINE1, CFP, THBD, LIF, PROC

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 283)
idTitleAuthorsYear
1
Fatal meningococcemia. (23882342)
2011
2
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
3
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
4
Purpuric rash of meningococcemia. (18438796)
2008
5
Meningococcemia without meningitis in Japan. (18758132)
2008
6
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
7
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
11
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
12
Meningococcemia following tonsillectomy. (11868768)
2001
13
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
14
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
15
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
16
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
17
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
18
Treatment of purpura fulminans in meningococcemia with protein C concentrate. (7699550)
1995
19
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
20
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. (8399877)
1993
21
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
22
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia. (2320962)
1990
23
Post-trauma meningococcemia in C7 deficiency. (2401619)
1990
24
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia. (2585216)
1989
25
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
26
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
27
Chronic meningococcemia. (3123131)
1987
28
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
29
Chronic meningococcemia. (6523901)
1984
30
Myocardial dysfunction in children with acute meningococcemia. (6481530)
1984
31
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
32
Fulminant meningococcemia. (6944045)
1981
33
Chronic meningococcemia. (6772999)
1980
34
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
35
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
36
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
37
Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. (4925594)
1971
38
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971
39
Severe temporary deterioration of renal transplant function following meningococcemia. (5002590)
1971
40
Chronic meningococcemia. (4993239)
1970
41
Heparin therapy in fulminant meningococcemia. (5804192)
1969
42
Consumptive coagulopathy in fulminant meningococcemia. (5694791)
1968
43
Intravascular coagulation in fulminant meningococcemia. (4962442)
1967
44
Chronic meningococcemia. Report of a case. (14497365)
1962
45
Clinical staff conference on meningococcemia. (13518486)
1958
46
Chronic meningococcemia. (13340577)
1956
47
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LIF, THBD
29.4IL1A, IL1B
39.4IL1A, IL1B
49.4IL1A, IL1B
59.2IL1B, CCL5, LIF
6
Show member pathways
9.1THBD, SERPINC1, PROC, F5
79.1IL1A, IL1B, CCL5
89.1CCL5, IL1B, IL1A
9
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8SERPINE1, CCL5, IL1B
108.8IL1A, IL1B, IL1RN
11
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
8.8IL1RN, IL1B, IL1A
12
Show member pathways
8.8IL1RN, IL1B, IL1A
13
Show member pathways
8.7IL1A, IL1B, CCL5, CFP
14
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
15
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
16
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
178.6IL1A, IL1B, SERPINE1
18
Show member pathways
8.3F5, PROC, SERPINC1, SERPINE1, THBD
19
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.3THBD, SERPINE1, SERPINC1, PROC, F5
20
Show member pathways
8.3THBD, SERPINE1, SERPINC1, PROC, F5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.0IL1A, IL1B, IL1RN, SERPINE1

Compounds for genes affiliated with Meningococcemia

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Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1hirugen459.9F5, SERPINC1, THBD
2ximelagatran45 1310.8THBD, SERPINC1, F5
3heparinoids459.8SERPINC1, F5, THBD
4fondaparinux459.7SERPINC1, THBD, F5
5gamma-carboxyglutamic acid459.6PROC, THBD, F5, PROCR
6bivalirudin45 1310.5F5, SERPINC1, THBD
7dermatan sulfate459.5THBD, CCL5, F5, SERPINC1
8warfarin45 51 26 1312.3SERPINC1, F5, PROC, THBD
9ancrod459.2THBD, SERPINE1, SERPINC1, F5
10desmopressin45 61 30 1312.1F5, THBD, SERPINE1, SERPINC1
11gm-csf45 3010.0CCL5, LIF, IL1A, IL1B
12raloxifene45 51 30 1312.0SERPINE1, THBD, F5, SERPINC1
13hirudin458.9SERPINE1, THBD, F5, PROCR, SERPINC1
14kininogen458.8THBD, SERPINC1, F5, SERPINE1
15polysaccharide458.8F5, BPI, LIF, SERPINC1, CFP, THBD
16polyethylene glycol458.8F5, IL1A, IL1RN, SERPINC1, THBD
17homocysteine45 269.8SERPINE1, F5, SERPINC1, THBD, CCL5
18pentoxifylline45 139.7IL1RN, THBD, IL1B, IL1A
19nacl458.7IL1RN, LIF, THBD, CCL5, F5
20calcitriol45 61 26 1311.6IL1A, IL1B, CCL5, THBD, LIF
21aprotinin45 139.6IL1A, SERPINC1, SERPINE1, THBD, F5
22neopterin458.5IL1RN, IL1A, IL1B, THBD
23lactate458.5LIF, BPI, CCL5, IL1RN, THBD, F5
24il 10458.4LIF, IL1RN, CCL5, IL1B, IL1A
25prostaglandin458.3IL1A, IL1B, IL1RN, LIF, CCL5
26pge1458.3IL1A, F5, IL1RN, SERPINE1, THBD
27fmlp458.2CCL5, IL1RN, BPI, LIF, IL1B, IL1A
28hydrocortisone45 3 61 1311.1LIF, IL1B, F5, IL1A, CCL5, IL1RN
29prostacyclin458.1SERPINC1, IL1B, F5, THBD, SERPINE1, IL1A
30pge2458.1IL1A, SERPINC1, LIF, CCL5, IL1RN, IL1B
31ascorbic acid45 269.0IL1RN, LIF, SERPINC1, CFP, THBD, IL1A
32simvastatin45 51 61 30 26 1313.0IL1A, IL1RN, CCL5, SERPINE1, THBD, F5
33actinomycin d457.9IL1B, IL1A, THBD, BPI, SERPINE1, LIF
34rantes457.9IL1B, IL1RN, CCL5, LIF, IL1A
35polymyxin b457.9BPI, IL1A, THBD, SERPINE1, IL1RN, IL1B
36cholesterol45 30 26 1310.7BPI, LIF, SERPINE1, THBD, CCL5, IL1RN
37aspirin45 51 30 2610.7F5, IL1B, IL1RN, CCL5, SERPINC1, SERPINE1
38sb 20358045 618.6IL1A, IL1B, IL1RN, LIF, SERPINE1, CCL5
39cysteine457.5IL1RN, CCL5, BPI, F5, CFP, LIF
40fibrinogen457.4SERPINE1, PROCR, F5, IL1RN, SERPINC1, LIF
41estrogen457.4THBD, CCL5, F5, SERPINC1, IL1RN, SERPINE1
42cycloheximide457.3IL1A, THBD, SERPINE1, LIF, CCL5, IL1RN
43dexamethasone45 51 30 1310.0IL1A, LIF, THBD, SERPINE1, IL1RN, SERPINC1
44creatinine457.0SERPINE1, F5, IL1RN, CCL5, BPI, IL1A
45retinoic acid45 267.7IL1A, THBD, SERPINE1, LIF, BPI, CCL5
46endotoxin456.5CCL5, IL1RN, THBD, F5, IL1A, IL1B
47nitric oxide45 26 138.5THBD, BPI, IL1RN, IL1B, IL1A, F5
48serine456.3THBD, F5, IL1A, SERPINC1, CCL5, BPI
49vegf456.2PROCR, LIF, SERPINC1, SERPINE1, THBD, BPI
50heparin45 30 26 139.2SERPINC1, LIF, PROC, BPI, CCL5, IL1RN

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.9SERPINE1, SERPINC1, PROC, CCL5, IL1B, IL1A
2extracellular spaceGO:00056155.6F5, THBD, CFP, SERPINE1, SERPINC1, LIF

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide-mediated signaling pathwayGO:00316639.8IL1B, CCL5
2protein kinase B signalingGO:00434919.7CCL5, IL1B
3ectopic germ cell programmed cell deathGO:00352349.7IL1B, IL1A
4positive regulation of interleukin-2 biosynthetic processGO:00450869.7IL1A, IL1B
5negative regulation of fibrinolysisGO:00519189.6SERPINE1, THBD
6cellular response to organic cyclic compoundGO:00714079.6CCL5, IL1B
7positive regulation vascular endothelial growth factor productionGO:00105759.6IL1B, IL1A
8positive regulation of monocyte chemotaxisGO:00900269.6SERPINE1, CCL5
9positive regulation of mitosisGO:00458409.6IL1A, IL1B
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.5IL1A, IL1B
11extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4IL1A, IL1B
12embryo implantationGO:00075669.4LIF, IL1B
13positive regulation of interleukin-8 productionGO:00327579.4SERPINE1, IL1B
14negative regulation of blood coagulationGO:00301959.3PROC, SERPINE1, THBD
15fever generationGO:00016609.1IL1A, IL1B, IL1RN
16positive regulation of angiogenesisGO:00457668.9IL1A, IL1B, SERPINE1
17blood coagulationGO:00075968.4THBD, SERPINE1, SERPINC1, PROC, PROCR, F5
18positive regulation of transcription from RNA polymerase II promoterGO:00459447.9IL1A, IL1B, LIF, SERPINE1
19immune responseGO:00069557.8IL1A, CFP, LIF, PROCR, BPI, IL1RN

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL1A, IL1B, LIF
2interleukin-1 receptor bindingGO:00051498.5IL1A, IL1B, IL1RN

Products for genes affiliated with Meningococcemia

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Sources for Meningococcemia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet