MCID: MNN021
MIFTS: 48

Meningococcemia malady

Rare diseases category

Summaries for Meningococcemia

About this section


Wikipedia:64 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to purpura and complement deficiency. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cytokine Network. The compounds hirugen and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are embryogenesis and liver/biliary system.

Aliases & Classifications for Meningococcemia

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Meningococcemia, Aliases & Descriptions:

Name: Meningococcemia 42 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Meningococcemia

About this section

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.6SERPINC1
2complement deficiency30.5LIF, CFP
3arthritis30.3IL1A, IL1B
4thrombocytopenia30.2F5, IL1A, SERPINC1, THBD
5neisseria meningitidis infection30.2CFP, IL1RN
6tuberculosis30.0IL1B, BPI
7disseminated intravascular coagulation30.0THBD, SERPINE1, SERPINC1, LIF, PROC, F5
8acute myocardial infarction29.8THBD, SERPINE1, SERPINC1, CCL5
9myocardial infarction29.6SERPINE1, SERPINC1, PROCR, CCL5, F5
10sepsis28.3THBD, SERPINE1, SERPINC1, PROC, PROCR, BPI
11septic shock28.2THBD, CFP, SERPINE1, SERPINC1, LIF, BPI
12meningitis10.6
13central retinal vein occlusion10.5F5
14sneddon syndrome10.5SERPINC1
15branch retinal artery occlusion10.5F5
16mediterranean spotted fever10.5THBD
17factor xi deficiency10.5F5
18periapical granuloma10.5CCL5
19degenerative disc disease10.5IL1B
20eclampsia10.4SERPINC1, THBD
21waterhouse-friderichsen syndrome10.4
22gastric cancer risk after h. pylori infection10.4IL1RN
23post-thrombotic syndrome10.4SERPINC1, F5
24legg-calve-perthes disease10.4SERPINC1, F5
25placental abruption10.4SERPINC1, F5
26prothrombin deficiency10.4F5, SERPINC1
27sagittal sinus thrombosis10.4SERPINC1, F5
28hepatic vein thrombosis10.4SERPINC1, F5
29retinal vein occlusion10.4F5, SERPINC1
30meningococcal meningitis10.4
31blood protein disease10.4SERPINC1, F5
32portal vein thrombosis10.4SERPINC1, F5
33antithrombin iii deficiency10.4SERPINC1, F5
34intracranial thrombosis10.4SERPINC1, F5
35factor xii deficiency10.4SERPINC1, F5
36mastitis10.3IL1B
37factor vii deficiency10.3SERPINC1, F5
38factor viii deficiency10.3SERPINC1, F5
39afibrinogenemia10.3CFP, F5
40otitis media10.3IL1B
41carotid artery thrombosis10.3SERPINE1
42dengue shock syndrome10.3IL1RN, THBD
43dysfibrinogenemia10.3THBD, SERPINC1, F5
44hemorrhagic disease10.3THBD, SERPINC1, F5
45idiopathic myopathy10.3CCL5, IL1A
46pulmonary embolism10.3SERPINC1, F5
47oral lichen planus10.3CCL5, IL1A
48polymyalgia rheumatica10.2CCL5, IL1RN
49homocystinuria10.2SERPINC1, F5
50alcoholic hepatitis10.2CCL5, IL1A

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

About this section

Drugs & Therapeutics for Meningococcemia

About this section

Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

About this section

Anatomical Context for Meningococcemia

About this section

MalaCards organs/tissues related to Meningococcemia:

32
Skin, Bone, Testes, Heart, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Meningococcemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F5, PROCR, LIF, SERPINC1, THBD
2MP:00053707.9THBD, SERPINE1, SERPINC1, LIF, PROC, F5
3MP:00107717.6THBD, SERPINE1, LIF, IL1RN, F5
4MP:00053787.2THBD, SERPINE1, LIF, PROC, PROCR, IL1RN
5MP:00107686.2SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
6MP:00053976.1LIF, SERPINC1, SERPINE1, THBD, PROC, PROCR
7MP:00053856.0SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
8MP:00053875.8IL1A, THBD, CFP, SERPINE1, SERPINC1, LIF
9MP:00053765.7SERPINC1, SERPINE1, CFP, THBD, LIF, PROC

Publications for Meningococcemia

About this section

Articles related to Meningococcemia:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Fatal meningococcemia. (23882342)
2011
2
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
3
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
4
Purpuric rash of meningococcemia. (18438796)
2008
5
Meningococcemia without meningitis in Japan. (18758132)
2008
6
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
7
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
11
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
12
Meningococcemia following tonsillectomy. (11868768)
2001
13
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
14
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
15
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
16
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
17
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
18
Treatment of purpura fulminans in meningococcemia with protein C concentrate. (7699550)
1995
19
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
20
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
21
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia. (2320962)
1990
22
Post-trauma meningococcemia in C7 deficiency. (2401619)
1990
23
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia. (2585216)
1989
24
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
25
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
26
Chronic meningococcemia. (3123131)
1987
27
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
28
Chronic meningococcemia. (6523901)
1984
29
Myocardial dysfunction in children with acute meningococcemia. (6481530)
1984
30
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
31
Fulminant meningococcemia. (6944045)
1981
32
Chronic meningococcemia. (6772999)
1980
33
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
34
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
35
Meningococcemia presenting as septic arthritis: case report. (4208724)
1974
36
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
37
Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. (4925594)
1971
38
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971
39
Severe temporary deterioration of renal transplant function following meningococcemia. (5002590)
1971
40
Chronic meningococcemia. (4993239)
1970
41
Heparin therapy in fulminant meningococcemia. (5804192)
1969
42
Consumptive coagulopathy in fulminant meningococcemia. (5694791)
1968
43
Intravascular coagulation in fulminant meningococcemia. (4962442)
1967
44
Chronic meningococcemia. Report of a case. (14497365)
1962
45
Clinical staff conference on meningococcemia. (13518486)
1958
46
Chronic meningococcemia. (13340577)
1956
47
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

About this section

Expression for genes affiliated with Meningococcemia

About this section
Expression patterns in normal tissues for genes affiliated with Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

About this section

Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LIF, THBD
29.4IL1A, IL1B
39.4IL1A, IL1B
49.4IL1A, IL1B
59.2IL1B, CCL5, LIF
6
Show member pathways
9.1THBD, SERPINC1, PROC, F5
79.1IL1A, IL1B, CCL5
89.1CCL5, IL1B, IL1A
9
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8SERPINE1, CCL5, IL1B
108.8IL1A, IL1B, IL1RN
11
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
8.8IL1RN, IL1B, IL1A
12
Show member pathways
8.8IL1RN, IL1B, IL1A
13
Show member pathways
8.7IL1A, IL1B, CCL5, CFP
14
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
15
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
16
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
178.6IL1A, IL1B, SERPINE1
18
Show member pathways
8.3F5, PROC, SERPINC1, SERPINE1, THBD
19
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.3THBD, SERPINE1, SERPINC1, PROC, F5
20
Show member pathways
8.3THBD, SERPINE1, SERPINC1, PROC, F5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.0IL1A, IL1B, IL1RN, SERPINE1

Compounds for genes affiliated with Meningococcemia

About this section

Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1hirugen449.9F5, SERPINC1, THBD
2ximelagatran44 1210.8THBD, SERPINC1, F5
3heparinoids449.8SERPINC1, F5, THBD
4fondaparinux449.7SERPINC1, THBD, F5
5gamma-carboxyglutamic acid449.6PROC, THBD, F5, PROCR
6bivalirudin44 1210.5F5, SERPINC1, THBD
7dermatan sulfate449.5THBD, CCL5, F5, SERPINC1
8warfarin44 50 25 1212.3SERPINC1, F5, PROC, THBD
9ancrod449.2THBD, SERPINE1, SERPINC1, F5
10desmopressin44 60 29 1212.1F5, THBD, SERPINE1, SERPINC1
11gm-csf44 2910.0CCL5, LIF, IL1A, IL1B
12raloxifene44 50 29 1212.0SERPINE1, THBD, F5, SERPINC1
13hirudin448.9SERPINE1, THBD, F5, PROCR, SERPINC1
14kininogen448.8THBD, SERPINC1, F5, SERPINE1
15polysaccharide448.8F5, BPI, LIF, SERPINC1, CFP, THBD
16polyethylene glycol448.8F5, IL1A, IL1RN, SERPINC1, THBD
17homocysteine44 259.8SERPINE1, F5, SERPINC1, THBD, CCL5
18pentoxifylline44 129.7IL1RN, THBD, IL1B, IL1A
19nacl448.7IL1RN, LIF, THBD, CCL5, F5
20calcitriol44 60 25 1211.6IL1A, IL1B, CCL5, THBD, LIF
21aprotinin44 129.6IL1A, SERPINC1, SERPINE1, THBD, F5
22neopterin448.5IL1RN, IL1A, IL1B, THBD
23lactate448.5LIF, BPI, CCL5, IL1RN, THBD, F5
24il 10448.4LIF, IL1RN, CCL5, IL1B, IL1A
25prostaglandin448.3IL1A, IL1B, IL1RN, LIF, CCL5
26pge1448.3IL1A, F5, IL1RN, SERPINE1, THBD
27fmlp448.2CCL5, IL1RN, BPI, LIF, IL1B, IL1A
28hydrocortisone44 3 60 1211.1LIF, IL1B, F5, IL1A, CCL5, IL1RN
29prostacyclin448.1SERPINC1, IL1B, F5, THBD, SERPINE1, IL1A
30pge2448.1IL1A, SERPINC1, LIF, CCL5, IL1RN, IL1B
31ascorbic acid44 259.0IL1RN, LIF, SERPINC1, CFP, THBD, IL1A
32simvastatin44 50 60 29 25 1213.0IL1A, IL1RN, CCL5, SERPINE1, THBD, F5
33actinomycin d447.9IL1B, IL1A, THBD, BPI, SERPINE1, LIF
34rantes447.9IL1B, IL1RN, CCL5, LIF, IL1A
35polymyxin b447.9BPI, IL1A, THBD, SERPINE1, IL1RN, IL1B
36cholesterol44 29 25 1210.7BPI, LIF, SERPINE1, THBD, CCL5, IL1RN
37aspirin44 50 29 2510.7F5, IL1B, IL1RN, CCL5, SERPINC1, SERPINE1
38sb 20358044 608.6IL1A, IL1B, IL1RN, LIF, SERPINE1, CCL5
39cysteine447.5IL1RN, CCL5, BPI, F5, CFP, LIF
40fibrinogen447.4SERPINE1, PROCR, F5, IL1RN, SERPINC1, LIF
41estrogen447.4THBD, CCL5, F5, SERPINC1, IL1RN, SERPINE1
42cycloheximide447.3IL1A, THBD, SERPINE1, LIF, CCL5, IL1RN
43dexamethasone44 50 29 1210.0IL1A, LIF, THBD, SERPINE1, IL1RN, SERPINC1
44creatinine447.0SERPINE1, F5, IL1RN, CCL5, BPI, IL1A
45retinoic acid44 257.7IL1A, THBD, SERPINE1, LIF, BPI, CCL5
46endotoxin446.5CCL5, IL1RN, THBD, F5, IL1A, IL1B
47nitric oxide44 25 128.5THBD, BPI, IL1RN, IL1B, IL1A, F5
48serine446.3THBD, F5, IL1A, SERPINC1, CCL5, BPI
49vegf446.2PROCR, LIF, SERPINC1, SERPINE1, THBD, BPI
50heparin44 29 25 129.2SERPINC1, LIF, PROC, BPI, CCL5, IL1RN

GO Terms for genes affiliated with Meningococcemia

About this section

Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.9SERPINE1, SERPINC1, PROC, CCL5, IL1B, IL1A
2extracellular spaceGO:0056155.6F5, THBD, CFP, SERPINE1, SERPINC1, LIF

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL1B, CCL5
2protein kinase B signalingGO:0434919.7CCL5, IL1B
3ectopic germ cell programmed cell deathGO:0352349.7IL1B, IL1A
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7IL1A, IL1B
5negative regulation of fibrinolysisGO:0519189.6SERPINE1, THBD
6cellular response to organic cyclic compoundGO:0714079.6CCL5, IL1B
7positive regulation vascular endothelial growth factor productionGO:0105759.6IL1B, IL1A
8positive regulation of monocyte chemotaxisGO:0900269.6SERPINE1, CCL5
9positive regulation of mitosisGO:0458409.6IL1A, IL1B
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1A, IL1B
11extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4IL1A, IL1B
12embryo implantationGO:0075669.4LIF, IL1B
13positive regulation of interleukin-8 productionGO:0327579.4SERPINE1, IL1B
14negative regulation of blood coagulationGO:0301959.3PROC, SERPINE1, THBD
15fever generationGO:0016609.1IL1A, IL1B, IL1RN
16positive regulation of angiogenesisGO:0457668.9IL1A, IL1B, SERPINE1
17blood coagulationGO:0075968.4THBD, SERPINE1, SERPINC1, PROC, PROCR, F5
18positive regulation of transcription from RNA polymerase II promoterGO:0459447.9IL1A, IL1B, LIF, SERPINE1
19immune responseGO:0069557.8IL1A, CFP, LIF, PROCR, BPI, IL1RN

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1A, IL1B, LIF
2interleukin-1 receptor bindingGO:0051498.5IL1A, IL1B, IL1RN

Products for genes affiliated with Meningococcemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Meningococcemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet