MCID: MNN021
MIFTS: 42

Meningococcemia malady

Summaries for Meningococcemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards: Meningococcemia is related to purpura fulminans and vasculitis. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Platelet activation, signaling and aggregation and Senescence and Autophagy. The compounds hydrocortisone and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and skin, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Aliases & Classifications for Meningococcemia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Aliases & Descriptions:

meningococcemia 43 45 61


Related Diseases for Meningococcemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1purpura fulminans30.6F5, PROCR, PROC, SERPINC1
2vasculitis30.1THBD, BPI
3thrombocytopenia30.0F5, IL1A, THBD, SERPINC1
4arthritis30.0IL1B, IL1A
5sepsis30.0SERPINC1, SERPINE1, THBD, BPI, F5, PROCR
6septic shock30.0BPI, F5, LIF, IL1RN, IL1A, IL1B
7leukopenia29.8BPI
8uveitis29.8IL1A
9neisseria meningitidis infection29.8IL1RN, CFP
10tuberculosis29.8BPI, IL1B
11protein s deficiency29.8SERPINC1, SERPINE1, F5
12acute myocardial infarction29.8CCL5, THBD, SERPINE1, SERPINC1
13protein c deficiency29.8F5, PROCR, PROC, CFP, THBD, SERPINE1
14waterhouse-friderichsen syndrome10.4
15waterhouse–friderichsen syndrome10.4
16complement component deficiency10.3
17meningococcal meningitis10.3
18meningococcal infection10.1
19osteonecrosis10.1
20septic arthritis10.1
21adult syndrome10.1
22shwartzman phenomenon10.1
23n syndrome10.1
24properdin deficiency10.1
25cystic fibrosis10.0BPI
26purpura10.0SERPINC1
27hemolytic-uremic syndrome10.0THBD
28nephrotic syndrome10.0SERPINC1
29polycythemia vera10.0THBD
30wegener's granulomatosis10.0BPI
31liver cirrhosis10.0SERPINC1
32herpes simplex10.0CCL5
33atopy10.0CCL5
34hepatocellular carcinoma10.0CCL5
35allergic rhinitis10.0CCL5
36ovarian hyperstimulation syndrome10.0F5
37rhinitis10.0CCL5
38central retinal vein occlusion10.0F5
39primary pulmonary hypertension10.0THBD
40bronchiolitis10.0CCL5
41branch retinal artery occlusion10.0F5
42sneddon syndrome10.0SERPINC1
43retinal vascular occlusion10.0F5
44infertility10.0LIF
45otitis media10.0IL1B
46influenza10.0CCL5
47pancreatitis10.0IL1B
48familial mediterranean fever10.0IL1B
49factor xi deficiency10.0F5
50mastitis10.0IL1B

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Clinical Features for Meningococcemia

Drugs & Therapeutics for Meningococcemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Meningococcemia

Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Search CenterWatch for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Meningococcemia:

33
Heart, Skeletal muscle, Skin, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Meningococcemia

Sources:
51PubMed
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Articles related to Meningococcemia:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. (23247497)
2012
2
Fatal meningococcemia. (23882342)
2011
3
Diagnosing meningococcemia as a cause of sepsis. (15857559)
2005
4
Images in emergency medicine. Petechiae and purpura associated with meningococcemia. (15855959)
2005
5
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
6
Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. (11445748)
2001
7
Oral antibiotics and outcome in meningococcemia. (10904473)
2000
8
Meningococcemia in a patient coinfected with hepatitis C virus and HIV. (11076725)
2000
9
Nosocomial meningococcemia in a physician. (10466560)
1999
10
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
11
Inducement of Neisseria meningitidis resistance to ampicillin and penicillin in a patient with meningococcemia treated with high doses of ampicillin. (9524869)
1998
12
Chronic meningococcemia in childhood: case report and review of the literature. (8987058)
1996
13
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
14
Circulating leukemia inhibitory factor levels correlate with disease severity in meningococcemia. (7963717)
1994
15
Could natural inhibitors of tumor necrosis factor-alpha modify the clinical course of fulminant meningococcemia? (8396525)
1993
16
Case 1: Chronic meningococcemia. (1620670)
1992
17
Meningococcemia: an undescribed cause of community-acquired bacteremia in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. (2106784)
1990
18
Plasmapheresis for fulminant meningococcemia. (2501752)
1989
19
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
20
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
21
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
22
Tenosynovitis in meningococcemia. (3103633)
1987
23
Meningococcemia in a patient with acquired complement deficiency and myeloma. (6493297)
1984
24
Gastrointestinal disease associated with meningococcemia. (6428281)
1984
25
Recurrent meningococcemia associated with IgG2-subclass deficiency. (6877301)
1983
26
Mycoplasma infection simulating acute meningococcemia. (6614967)
1983
27
Meningococcemia caused by serogroup W135. Association with hypogammaglobulinemia. (6784688)
1981
28
Chronic meningococcemia. (6772999)
1980
29
Fulminant gonococcemia of fulminant meningococcemia? (6777027)
1980
30
Fulminant meningococcemia in a child with hereditary deficiency of the seventh component of complement and proteinuria. (7446104)
1980
31
Staphylococcal septicemia and disseminated intravascular coagulation. Staphylococcus aureus endocarditis mimicking meningococcemia. (879923)
1977
32
Meningococcemia in a newborn infant whose mother had meningococcal vaginitis. (4627520)
1972
33
Fulminant meningococcemia. Heparin therapy and survival rate. (5123803)
1971
34
Chronic meningococcemia. (4993239)
1970
35
Immunoglobulin M in meningococcemia. (5267662)
1970
36
Fulminant meningococcemia and disseminated intravascular coagulation. (5791486)
1969
37
Meningococcemia and intravascular clotting: the use of heparin in management. (5681136)
1968
38
Prolonged mild meningococcemia in an infant. (6018223)
1967
39
Meningococcemia. (6080757)
1967
40
CHRONIC MENINGOCOCCEMIA. FURTHER COMMENTS ON THE PATHOGENESIS OF ASSOCIATED SKIN LESIONS. (14152125)
1964
41
Gangrenous purpura associated with meningococcemia. (13585645)
1958
42
ECHO virus type 9 associated with three cases simulating meningococcemia. (13578088)
1958
43
Acute meningococcemia with vascular collapse: an analysis of 10 recently treated cases. (13372539)
1956
44
Adrenal steroids in meningococcemia. (14368486)
1955
45
Fulminating meningococcemia with bilateral adrenal hemorrhage. (13192390)
1954
46
Meningococcemia with meningitis accompanied by bilateral gangrene of the lower extremities (Water-house-Friderichsen syndrome). (18131836)
1949
47
Meningococcemia without meningitis; a review of five cases. (20272362)
1947
48
Fulminating meningococcemia with gangrene. (20269248)
1947
49
Meningococcemia; a description of the clinical picture and a comparison of the efficacy of sulfadiazine and penicillin in the treatment of 30 cases. (21025278)
1946
50
Meningococcemia with four case reports. (21004914)
1945

Genetic Variations for Meningococcemia

Expression for genes affiliated with Meningococcemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2THBD
29.7SERPINE1
39.6IL1A, CCL5
49.4IL1B, IL1A
59.2CCL5, LIF, IL1B
6
Hide members
9.1F5, PROC, THBD, SERPINC1
78.8IL1B, IL1A, IL1RN
8
Hide members
8.8IL1RN, IL1A, IL1B
9
Immune response Bacterial infections in normal airways
Hide members
8.8IL1B, IL1A, IL1RN
10
Hide members
8.8IL1RN, IL1A, IL1B
11
Hide members
8.7CCL5, IL1A, IL1B, CFP
12
Hide members
8.6IL1A, IL1B, SERPINE1
13
Hide members
8.3F5, PROC, THBD, SERPINE1, SERPINC1
14
Hide members
8.3SERPINC1, SERPINE1, THBD, PROC, F5
15
Hide members
8.3F5, PROC, THBD, SERPINE1, SERPINC1

Compounds for genes affiliated with Meningococcemia

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1hydrocortisone45 2 60 1113.4LIF
2dexamethasone45 50 29 1113.1CCL5, LIF
3gm-csf45 2911.0CCL5, LIF
4warfarin45 50 11 2412.9PROC, SERPINC1
5hirugen459.9THBD, F5, SERPINC1
6ximelagatran45 1110.9SERPINC1, THBD, F5
7heparinoids459.9F5, SERPINC1, THBD
8fondaparinux459.8SERPINC1, F5, THBD
9bivalirudin45 1110.7F5, THBD, SERPINC1
10gamma-carboxyglutamic acid459.6THBD, F5, PROC, PROCR
11argatroban45 1110.5SERPINC1, THBD, F5
12dermatan sulfate459.5F5, SERPINC1, THBD, CCL5
13raloxifene45 29 50 1112.3SERPINE1, SERPINC1, F5
14Drotrecogin alfa119.2F5, SERPINE1, PROCR, THBD
15kininogen459.2F5, SERPINC1, SERPINE1
16ancrod459.2SERPINE1, THBD, SERPINC1, F5
17aprotinin45 1110.1SERPINC1, THBD, F5, SERPINE1
18prostaglandin459.1IL1B, IL1RN, IL1A
19desmopressin45 60 29 1112.1F5, SERPINE1, SERPINC1, THBD
20nacl459.0LIF, THBD, IL1RN, F5
21hirudin458.9THBD, SERPINE1, SERPINC1, F5, PROCR
22creatinine458.9THBD, IL1RN, F5, BPI, IL1A
23rantes458.9LIF, IL1B, IL1A
24thalidomide45 50 60 1111.8THBD, IL1A, CCL5, IL1B
25polysaccharide458.8LIF, BPI, F5, THBD, SERPINC1, CFP
26polyethylene glycol458.8THBD, IL1RN, IL1A, F5, SERPINC1
27pentoxifylline45 119.8IL1A, IL1B, IL1RN, THBD
28homocysteine45 249.8SERPINC1, SERPINE1, THBD, F5, CCL5
29serine458.7LIF, PROCR, IL1A, IL1RN, CCL5
30calcitriol45 60 11 2411.6IL1A, LIF, IL1B, THBD, CCL5
31neopterin458.6IL1B, THBD, IL1A, IL1RN
32endotoxin458.5SERPINE1, PROCR, THBD, F5, BPI, LIF
33il 10458.4IL1RN, IL1B, IL1A, CCL5, LIF
34lactate458.4THBD, IL1RN, CCL5, BPI, LIF, F5
35heparin45 29 11 2411.4CCL5, BPI, LIF, IL1RN, IL1A, CFP
36pge1458.3F5, THBD, SERPINE1, IL1RN, IL1A
37fmlp458.2IL1RN, IL1A, IL1B, LIF, CCL5, BPI
38prostacyclin458.1THBD, F5, IL1A, SERPINC1, SERPINE1, IL1B
39ascorbic acid45 249.0SERPINC1, F5, IL1RN, IL1A, CFP, THBD
40simvastatin45 50 60 29 11 2413.0IL1A, IL1RN, SERPINE1, THBD, F5, CCL5
41actinomycin d457.9IL1A, IL1B, THBD, BPI, SERPINE1, LIF
42polymyxin b457.9IL1A, BPI, IL1RN, IL1B, THBD, SERPINE1
43ribonucleic acid457.7CCL5, LIF, IL1RN, IL1B, IL1A
44cholesterol45 29 11 2410.7THBD, LIF, SERPINE1, BPI, CCL5, F5
45aspirin45 50 29 2410.7CCL5, SERPINC1, IL1RN, IL1B, THBD, SERPINE1
46sb 20358045 608.6SERPINE1, CCL5, IL1B, IL1A, IL1RN, LIF
47fibrinogen457.4PROC, IL1RN, LIF, SERPINE1, SERPINC1, THBD
48retinoic acid45 247.7LIF, IL1RN, BPI, SERPINE1, IL1A, F5
49nitric oxide45 11 248.5IL1A, IL1RN, PROCR, F5, CCL5, SERPINE1
50vegf456.2CCL5, BPI, SERPINE1, F5, PROCR, LIF

GO Terms for genes affiliated with Meningococcemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.6BPI, CCL5, F5, PROC, IL1A, IL1B
2extracellular spaceGO:0056155.9CCL5, F5, LIF, IL1RN, IL1A, IL1B

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.6IL1A, IL1B
2negative regulation of fibrinolysisGO:0519189.5SERPINE1, THBD
3positive regulation of interleukin-2 biosynthetic processGO:0450869.4IL1A, IL1B
4negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, IL1A
5positive regulation of monocyte chemotaxisGO:0900269.4SERPINE1, CCL5
6positive regulation vascular endothelial growth factor productionGO:0105759.3IL1B, IL1A
7negative regulation of blood coagulationGO:0301959.2SERPINE1, THBD, PROC
8positive regulation of interleukin-8 productionGO:0327578.8SERPINE1, IL1B
9positive regulation of angiogenesisGO:0457668.8SERPINE1, IL1B, IL1A
10blood coagulationGO:0075968.3F5, PROCR, PROC, THBD, SERPINE1, SERPINC1
11immune responseGO:0069557.7CFP, BPI, PROCR, LIF, IL1RN, IL1A

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1B, IL1A, LIF
2interleukin-1 receptor bindingGO:0051498.5IL1B, IL1A, IL1RN

Products for genes affiliated with Meningococcemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningococcemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet