Aliases & Classifications for Meningococcemia

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
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Meningococcemia, Aliases & Descriptions:

Name: Meningococcemia 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Meningococcemia

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Wikipedia:63 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to purpura and complement deficiency. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cytokine Network. The compounds hirugen and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are embryogenesis and liver/biliary system.

Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.7SERPINC1
2complement deficiency30.5LIF, CFP
3arthritis30.3IL1A, IL1B
4thrombocytopenia30.2F5, IL1A, SERPINC1, THBD
5tuberculosis30.0IL1B, BPI
6disseminated intravascular coagulation29.9THBD, SERPINE1, SERPINC1, LIF, PROC, F5
7acute myocardial infarction29.8THBD, SERPINE1, SERPINC1, CCL5
8myocardial infarction29.6SERPINE1, SERPINC1, PROCR, CCL5, F5
9protein c deficiency29.1THBD, CFP, SERPINE1, SERPINC1, PROC, PROCR
10meningitis10.6
11central retinal vein occlusion10.5F5
12sneddon syndrome10.5SERPINC1
13branch retinal artery occlusion10.5F5
14mediterranean spotted fever10.5THBD
15factor xi deficiency, autosomal recessive10.5F5
16periapical granuloma10.5CCL5
17intervertebral disc disease10.5IL1B
18eclampsia10.4SERPINC1, THBD
19waterhouse-friderichsen syndrome10.4
20gastric cancer risk after h. pylori infection10.4IL1RN
21post-thrombotic syndrome10.4SERPINC1, F5
22legg-calve-perthes disease10.4SERPINC1, F5
23placental abruption10.4SERPINC1, F5
24hypoprothrombinemia10.4F5, SERPINC1
25meningococcal meningitis10.4
26sagittal sinus thrombosis10.4SERPINC1, F5
27budd-chiari syndrome10.4SERPINC1, F5
28retinal vein occlusion10.4F5, SERPINC1
29blood protein disease10.4SERPINC1, F5
30portal vein thrombosis10.4SERPINC1, F5
31thrombophilia due to antithrombin iii deficiency10.4SERPINC1, F5
32intracranial thrombosis10.4SERPINC1, F5
33factor xii deficiency10.4SERPINC1, F5
34mastitis10.3IL1B
35factor vii deficiency10.3SERPINC1, F5
36hemophilia a10.3SERPINC1, F5
37afibrinogenemia10.3CFP, F5
38otitis media10.3IL1B
39carotid artery thrombosis10.3SERPINE1
40dengue shock syndrome10.3IL1RN, THBD
41dysfibrinogenemia10.3THBD, SERPINC1, F5
42hemorrhagic disease10.3THBD, SERPINC1, F5
43idiopathic myopathy10.3CCL5, IL1A
44pulmonary embolism10.3SERPINC1, F5
45oral lichen planus10.3CCL5, IL1A
46polymyalgia rheumatica10.2CCL5, IL1RN
47homocystinuria10.2SERPINC1, F5
48alcoholic hepatitis10.2CCL5, IL1A
49skin disease10.2IL1A, IL1B
50bacterial meningitis10.2CFP, IL1B

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

31
Skin, Bone, Testes, Heart, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

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MGI Mouse Phenotypes related to Meningococcemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F5, PROCR, LIF, SERPINC1, THBD
2MP:00053707.9THBD, SERPINE1, SERPINC1, LIF, PROC, F5
3MP:00107717.6THBD, SERPINE1, LIF, IL1RN, F5
4MP:00053787.2THBD, SERPINE1, LIF, PROC, PROCR, IL1RN
5MP:00107686.2SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
6MP:00053976.1LIF, SERPINC1, SERPINE1, THBD, PROC, PROCR
7MP:00053856.0SERPINC1, SERPINE1, CFP, THBD, LIF, PROC
8MP:00053875.8IL1A, THBD, CFP, SERPINE1, SERPINC1, LIF
9MP:00053765.7SERPINC1, SERPINE1, CFP, THBD, LIF, PROC

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 283)
idTitleAuthorsYear
1
Fatal meningococcemia. (23882342)
2011
2
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
3
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
4
Purpuric rash of meningococcemia. (18438796)
2008
5
Meningococcemia without meningitis in Japan. (18758132)
2008
6
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
7
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
11
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
12
Meningococcemia following tonsillectomy. (11868768)
2001
13
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
14
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
15
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
16
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
17
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
18
Treatment of purpura fulminans in meningococcemia with protein C concentrate. (7699550)
1995
19
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
20
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. (8399877)
1993
21
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
22
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia. (2320962)
1990
23
Post-trauma meningococcemia in C7 deficiency. (2401619)
1990
24
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia. (2585216)
1989
25
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
26
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
27
Chronic meningococcemia. (3123131)
1987
28
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
29
Chronic meningococcemia. (6523901)
1984
30
Myocardial dysfunction in children with acute meningococcemia. (6481530)
1984
31
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
32
Fulminant meningococcemia. (6944045)
1981
33
Chronic meningococcemia. (6772999)
1980
34
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
35
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
36
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
37
Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. (4925594)
1971
38
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971
39
Severe temporary deterioration of renal transplant function following meningococcemia. (5002590)
1971
40
Chronic meningococcemia. (4993239)
1970
41
Heparin therapy in fulminant meningococcemia. (5804192)
1969
42
Consumptive coagulopathy in fulminant meningococcemia. (5694791)
1968
43
Intravascular coagulation in fulminant meningococcemia. (4962442)
1967
44
Chronic meningococcemia. Report of a case. (14497365)
1962
45
Clinical staff conference on meningococcemia. (13518486)
1958
46
Chronic meningococcemia. (13340577)
1956
47
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LIF, THBD
29.4IL1A, IL1B
39.4IL1A, IL1B
49.4IL1A, IL1B
59.2IL1B, CCL5, LIF
6
Show member pathways
9.1THBD, SERPINC1, PROC, F5
79.1IL1A, IL1B, CCL5
89.1CCL5, IL1B, IL1A
9
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8SERPINE1, CCL5, IL1B
108.8IL1A, IL1B, IL1RN
11
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
8.8IL1RN, IL1B, IL1A
12
Show member pathways
8.8IL1RN, IL1B, IL1A
13
Show member pathways
8.7IL1A, IL1B, CCL5, CFP
14
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
15
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
16
Show member pathways
8.7LIF, CCL5, IL1B, IL1A
178.6IL1A, IL1B, SERPINE1
18
Show member pathways
8.3F5, PROC, SERPINC1, SERPINE1, THBD
19
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.3THBD, SERPINE1, SERPINC1, PROC, F5
20
Show member pathways
8.3THBD, SERPINE1, SERPINC1, PROC, F5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.0IL1A, IL1B, IL1RN, SERPINE1

Compounds for genes affiliated with Meningococcemia

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Compounds related to Meningococcemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1hirugen439.9F5, SERPINC1, THBD
2ximelagatran43 1210.8THBD, SERPINC1, F5
3heparinoids439.8SERPINC1, F5, THBD
4fondaparinux439.7SERPINC1, THBD, F5
5gamma-carboxyglutamic acid439.6PROC, THBD, F5, PROCR
6bivalirudin43 1210.5F5, SERPINC1, THBD
7dermatan sulfate439.5THBD, CCL5, F5, SERPINC1
8warfarin43 49 24 1212.3SERPINC1, F5, PROC, THBD
9ancrod439.2THBD, SERPINE1, SERPINC1, F5
10desmopressin43 59 28 1212.1F5, THBD, SERPINE1, SERPINC1
11gm-csf43 2810.0CCL5, LIF, IL1A, IL1B
12raloxifene43 49 28 1212.0SERPINE1, THBD, F5, SERPINC1
13hirudin438.9SERPINE1, THBD, F5, PROCR, SERPINC1
14kininogen438.8THBD, SERPINC1, F5, SERPINE1
15polysaccharide438.8F5, BPI, LIF, SERPINC1, CFP, THBD
16polyethylene glycol438.8F5, IL1A, IL1RN, SERPINC1, THBD
17homocysteine43 249.8SERPINE1, F5, SERPINC1, THBD, CCL5
18pentoxifylline43 129.7IL1RN, THBD, IL1B, IL1A
19nacl438.7IL1RN, LIF, THBD, CCL5, F5
20calcitriol43 59 24 1211.6IL1A, IL1B, CCL5, THBD, LIF
21aprotinin43 129.6IL1A, SERPINC1, SERPINE1, THBD, F5
22neopterin438.5IL1RN, IL1A, IL1B, THBD
23lactate438.5LIF, BPI, CCL5, IL1RN, THBD, F5
24il 10438.4LIF, IL1RN, CCL5, IL1B, IL1A
25prostaglandin438.3IL1A, IL1B, IL1RN, LIF, CCL5
26pge1438.3IL1A, F5, IL1RN, SERPINE1, THBD
27fmlp438.2CCL5, IL1RN, BPI, LIF, IL1B, IL1A
28hydrocortisone43 2 59 1211.1LIF, IL1B, F5, IL1A, CCL5, IL1RN
29prostacyclin438.1SERPINC1, IL1B, F5, THBD, SERPINE1, IL1A
30pge2438.1IL1A, SERPINC1, LIF, CCL5, IL1RN, IL1B
31ascorbic acid43 249.0IL1RN, LIF, SERPINC1, CFP, THBD, IL1A
32simvastatin43 49 59 28 24 1213.0IL1A, IL1RN, CCL5, SERPINE1, THBD, F5
33actinomycin d437.9IL1B, IL1A, THBD, BPI, SERPINE1, LIF
34rantes437.9IL1B, IL1RN, CCL5, LIF, IL1A
35polymyxin b437.9BPI, IL1A, THBD, SERPINE1, IL1RN, IL1B
36cholesterol43 28 24 1210.7BPI, LIF, SERPINE1, THBD, CCL5, IL1RN
37aspirin43 49 28 2410.7F5, IL1B, IL1RN, CCL5, SERPINC1, SERPINE1
38sb 20358043 598.6IL1A, IL1B, IL1RN, LIF, SERPINE1, CCL5
39cysteine437.5IL1RN, CCL5, BPI, F5, CFP, LIF
40fibrinogen437.4SERPINE1, PROCR, F5, IL1RN, SERPINC1, LIF
41estrogen437.4THBD, CCL5, F5, SERPINC1, IL1RN, SERPINE1
42cycloheximide437.3IL1A, THBD, SERPINE1, LIF, CCL5, IL1RN
43dexamethasone43 49 28 1210.0IL1A, LIF, THBD, SERPINE1, IL1RN, SERPINC1
44creatinine437.0SERPINE1, F5, IL1RN, CCL5, BPI, IL1A
45retinoic acid43 247.7IL1A, THBD, SERPINE1, LIF, BPI, CCL5
46endotoxin436.5CCL5, IL1RN, THBD, F5, IL1A, IL1B
47nitric oxide43 24 128.5THBD, BPI, IL1RN, IL1B, IL1A, F5
48serine436.3THBD, F5, IL1A, SERPINC1, CCL5, BPI
49vegf436.2PROCR, LIF, SERPINC1, SERPINE1, THBD, BPI
50heparin43 28 24 129.2SERPINC1, LIF, PROC, BPI, CCL5, IL1RN

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.9SERPINE1, SERPINC1, PROC, CCL5, IL1B, IL1A
2extracellular spaceGO:00056155.6F5, THBD, CFP, SERPINE1, SERPINC1, LIF

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide-mediated signaling pathwayGO:00316639.8IL1B, CCL5
2protein kinase B signalingGO:00434919.7CCL5, IL1B
3ectopic germ cell programmed cell deathGO:00352349.7IL1B, IL1A
4positive regulation of interleukin-2 biosynthetic processGO:00450869.7IL1A, IL1B
5negative regulation of fibrinolysisGO:00519189.6SERPINE1, THBD
6cellular response to organic cyclic compoundGO:00714079.6CCL5, IL1B
7positive regulation vascular endothelial growth factor productionGO:00105759.6IL1B, IL1A
8positive regulation of monocyte chemotaxisGO:00900269.6SERPINE1, CCL5
9positive regulation of mitosisGO:00458409.6IL1A, IL1B
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.5IL1A, IL1B
11extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4IL1A, IL1B
12embryo implantationGO:00075669.4LIF, IL1B
13positive regulation of interleukin-8 productionGO:00327579.4SERPINE1, IL1B
14negative regulation of blood coagulationGO:00301959.3PROC, SERPINE1, THBD
15fever generationGO:00016609.1IL1A, IL1B, IL1RN
16positive regulation of angiogenesisGO:00457668.9IL1A, IL1B, SERPINE1
17blood coagulationGO:00075968.4THBD, SERPINE1, SERPINC1, PROC, PROCR, F5
18positive regulation of transcription from RNA polymerase II promoterGO:00459447.9IL1A, IL1B, LIF, SERPINE1
19immune responseGO:00069557.8IL1A, CFP, LIF, PROCR, BPI, IL1RN

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL1A, IL1B, LIF
2interleukin-1 receptor bindingGO:00051498.5IL1A, IL1B, IL1RN

Products for genes affiliated with Meningococcemia

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Sources for Meningococcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet