MCID: MNN021
MIFTS: 38

Meningococcemia malady

Category: Rare diseases

Aliases & Classifications for Meningococcemia

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Aliases & Descriptions for Meningococcemia:

Name: Meningococcemia 47 49 67

Classifications:



Summaries for Meningococcemia

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Wikipedia:70 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to c4b deficiency and bacteremia. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways are Interleukin-1 processing and Cytokines and Inflammatory Response. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1c4b deficiency30.1CFP, MBL2
2bacteremia29.7BPI, MBL2
3myocardial infarction26.5CCL5, F5, IL1B, PROCR, SERPINC1, SERPINE1
4diabetic cataract10.6IL1A, IL1B
5gout susceptibility 410.6CFP, MBL2
6rectosigmoid junction neoplasm10.5IL1A, IL1B
7atrial septal defect coronary sinus10.5IL1B, MBL2
8inflammatory breast carcinoma10.5CFP, MBL2
9hypercementosis10.4IL1A, IL1RN
10gastric cancer risk after h. pylori infection10.4IL1B, IL1RN
11silo filler's disease10.4IL1B, IL1RN
12periodic paralyses10.4IL1A, IL1B
13liver disease10.4IL1A, IL1B
14pseudoretinitis pigmentosa10.4IL1A, IL1B
15non-secretory myeloma10.4IL1B, IL1RN
16congenital granular cell tumor10.4CFP, IL1A, MBL2
17onychocytic matricoma10.4F5, MBL2
18congenital stenosis of the inferior vena cava10.3F5, SERPINE1
19ameloblastic carcinoma10.3F5, SERPINE1
20unicentric castleman disease10.3F5, SERPINE1
21peri-anal fistula10.3IL1A, IL1B, IL1RN
22anaerobic meningitis10.3IL1A, IL1B, IL1RN
23histiocytoid hemangioma10.3IL1A, IL1B, IL1RN
24dmd-related dilated cardiomyopathy10.3PROC, SERPINC1
25pharyngitis10.3IL1RN, MBL2
26sinusitis10.2IL1A, IL1B, IL1RN
27cartilage disease10.2IL1B, SERPINC1
28lymphangioma10.2IL1A, IL1B, IL1RN
29pleomorphic lipoma10.2IL1A, IL1B, IL1RN
30xanthomatosis10.2IL1A, IL1B, IL1RN
31west nile fever10.2F5, SERPINE1
32palmoplantar keratosis10.2IL1A, IL1B, IL1RN
33chronic rhinitis10.2IL1A, IL1B, IL1RN
34warm antibody hemolytic anemia10.2IL1B, IL1RN, MBL2
35venezuelan hemorrhagic fever10.2SERPINC1, SERPINE1
36cinca syndrome10.2IL1B, IL1RN
37retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.2F5, SERPINE1
38hypertensive heart disease10.2SERPINC1, SERPINE1
39meningitis10.2
40lateral cystocele10.2SERPINC1, SERPINE1
41posterolateral myocardial infarction10.2SERPINC1, SERPINE1
42purpura10.1
43chromophobe adenoma10.1SERPINE1, THBD
44catatrichy10.1F5, PROC, SERPINE1
45subcortical arteriosclerotic encephalopathy10.1F5, SERPINC1
46hepatic fibrosis renal cysts mental retardation10.1F5, SERPINC1
47charcot-marie-tooth disease10.1F5, IL1B, MBL2
48thrombophilia due to thrombin defect10.1F5, SERPINC1
49childhood central nervous system germinoma10.1F5, THBD
50purpura fulminans10.1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 3, Phase 26428
2
Hydrocortisoneapproved, vet_approvedPhase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
3
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
4Hydrocortisone acetatePhase 2640
5Hydrocortisone-17-butyratePhase 2318
6Hydrocortisone 17-butyrate 21-propionatePhase 2640
7AntibodiesPhase 26045
8ImmunoglobulinsPhase 26045
9Cortisol succinatePhase 2640
10Anti-Inflammatory AgentsPhase 210355

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap VaccineCompletedNCT00777257Phase 4
2Immunology and Safety of Menactra® in Children in Saudi ArabiaCompletedNCT00539032Phase 3
3Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in AdolescentsCompletedNCT00777790Phase 2
4Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in ChildrenCompletedNCT00771849Phase 2
5Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26CompletedNCT00700713Phase 2
6Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate VaccineCompletedNCT00772070Phase 2
7Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot StudyCompletedNCT00732277Phase 2
8Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy AdultsTerminatedNCT00772629Phase 2
9Correlation Between Cytokines and the Severity of Meningococcal DiseaseCompletedNCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

35
Skin, Bone, Testes, Atrioventricular node, Endothelial, Colon, Heart

Animal Models for Meningococcemia or affiliated genes

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MGI Mouse Phenotypes related to Meningococcemia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.7CFP, F5, IL1A, IL1B, IL1RN, PROC
2MP:00053976.8CCL5, IL1A, IL1B, IL1RN, MBL2, PROC
3MP:00053766.8CFP, F5, IL1A, IL1B, IL1RN, MBL2
4MP:00053876.4CCL5, CFP, IL1A, IL1B, IL1RN, MBL2

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. (24977653)
2014
2
Fatal meningococcemia. (23882342)
2011
3
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. (20841592)
2010
4
Giant condyloma with demise secondary to meningococcemia in an infant boy. (19596116)
2009
5
Purpuric rash of meningococcemia. (18438796)
2008
6
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
7
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. (17697137)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Diagnosing meningococcemia as a cause of sepsis. (15857559)
2005
11
Meningococcemia update vaccination and chemoprophylaxis. (16085964)
2005
12
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
13
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
14
Meningococcemia following tonsillectomy. (11868768)
2001
15
Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. (11445748)
2001
16
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
17
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
18
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
19
Meningococcemia with vitreous opacities: endophthalmitis or vitreous hemorrhage? (10037579)
1999
20
Acute meningococcemia. (9293739)
1997
21
Meningococcemia: heading off a killer. (20086968)
1996
22
Meningococcemia: recognizing and reducing complications in pediatric patients. (7780842)
1994
23
Chronic meningococcemia in an immunocompetent girl. (7928036)
1994
24
Fatal course in severe meningococcemia: clinical predictors and effect of transfusion therapy. (8222686)
1993
25
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
26
Orthopedic sequelae of meningococcemia. (2008386)
1991
27
Post-traumatic meningococcemia in a patient with deficiency of the C7 complement component. (2264845)
1990
28
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
29
Chronic meningococcemia. (3123131)
1987
30
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
31
Chronic meningococcemia. (6523901)
1984
32
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
33
Severe pulmonary edema in meningococcemia. (6839627)
1983
34
Chronic meningococcemia. (6772999)
1980
35
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
36
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
37
Staphylococcal septicemia and disseminated intravascular coagulation. Staphylococcus aureus endocarditis mimicking meningococcemia. (879923)
1977
38
Meningococcemia presenting as septic arthritis: case report. (4208724)
1974
39
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
40
Heparin therapy in fulminant meningococcemia. (5804192)
1969
41
Hypofibrinogenemia and thrombocytopenia with meningococcemia. (4225764)
1967
42
CHRONIC MENINGOCOCCEMIA. FURTHER COMMENTS ON THE PATHOGENESIS OF ASSOCIATED SKIN LESIONS. (14152125)
1964
43
Chronic meningococcemia. (13340577)
1956
44
Skin sloughs in patients with meningococcemia. (13245438)
1955
45
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
46
Generalized cutaneous herpes simplex; report of a case complicating meningococcemia. (14955744)
1952
47
Meningococcemia. (14782309)
1950
48
Meningococcemia. (20268800)
1947
49
Meningococcemia. (20278670)
1947
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1A, IL1B
29.9IL1A, IL1B
39.5IL1A, IL1B, SERPINE1
49.5IL1A, IL1B, IL1RN
5
Show member pathways
9.5IL1A, IL1B, IL1RN
6
Show member pathways
9.2PROC, PROCR, THBD
79.0CCL5, IL1A, IL1B
89.0CCL5, IL1A, IL1B
99.0CCL5, IL1A, IL1B
109.0IL1A, IL1B, SERPINE1, THBD
11
Show member pathways
8.8CCL5, CFP, IL1A, IL1B
12
Show member pathways
8.5F5, PROC, SERPINC1, THBD
13
Show member pathways
7.7F5, PROC, PROCR, SERPINC1, SERPINE1, THBD
14
Show member pathways
7.3F5, MBL2, PROC, PROCR, SERPINC1, SERPINE1

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055765.5CCL5, CFP, F5, IL1A, IL1B, IL1RN
2extracellular spaceGO:00056155.4BPI, CCL5, CFP, F5, IL1A, IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:000166010.5IL1A, IL1B
2positive regulation of monocyte chemotactic protein-1 productionGO:007163910.5IL1A, IL1B
3ectopic germ cell programmed cell deathGO:003523410.5IL1A, IL1B
4positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
5negative regulation of coagulationGO:005081910.4PROC, PROCR
6positive regulation of vascular endothelial growth factor productionGO:001057510.1IL1A, IL1B
7negative regulation of fibrinolysisGO:005191810.1SERPINE1, THBD
8positive regulation of interleukin-8 productionGO:003275710.0IL1B, SERPINE1
9defense response to bacteriumGO:00427429.9BPI, CFP, MBL2
10positive regulation of fever generationGO:00316229.9CCL5, IL1B
11positive regulation of mitotic nuclear divisionGO:00458409.9IL1A, IL1B
12negative regulation of blood coagulationGO:00301959.9PROC, SERPINE1, THBD
13positive regulation of monocyte chemotaxisGO:00900269.8CCL5, SERPINE1
14positive regulation of angiogenesisGO:00457668.9CCL5, IL1A, IL1B, SERPINE1
15leukocyte migrationGO:00509008.9IL1B, PROC, PROCR, THBD
16immune responseGO:00069558.7BPI, CFP, IL1A, IL1RN, PROCR
17blood coagulationGO:00075967.8F5, PROC, PROCR, SERPINC1, THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:000514910.4IL1A, IL1B
2cytokine activityGO:00051259.5IL1A, IL1B, IL1RN

Sources for Meningococcemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet