Aliases & Classifications for Meningococcemia

MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 49 51 69

Classifications:



External Ids:

UMLS 69 C0025306

Summaries for Meningococcemia

MalaCards based summary : Meningococcemia is related to meningococcal meningitis and meningitis. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-Like receptor Signaling Pathways. The drugs Vaccines and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 72 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Related Diseases for Meningococcemia

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 meningococcal meningitis 32.5 CFP MBL2
2 meningitis 30.8 CFP IL1B MBL2
3 purpura fulminans 30.2 PROC PROCR SERPINC1
4 bacteremia 2 30.0 BPI MBL2
5 purpura 29.7 PROC PROCR SERPINC1 THBD
6 disseminated intravascular coagulation 29.3 F5 SERPINC1 SERPINE1 THBD
7 shwartzman phenomenon 29.3 SERPINE1 THBD
8 protein c deficiency 28.7 F5 PROC SERPINC1 THBD
9 myocardial infarction 27.1 CCL5 F5 IL1B PROCR SERPINC1 SERPINE1
10 dengue disease 10.9
11 chronic follicular conjunctivitis 10.5 IL1A IL1B
12 scabies 10.4 IL1A MBL2
13 prosthetic joint infection 10.4 IL1B MBL2
14 mannose-binding lectin deficiency 10.4 CFP MBL2
15 neonatal stroke 10.4 PROC SERPINE1
16 irritant dermatitis 10.4 IL1A IL1B
17 limbal stem cell deficiency 10.3 IL1A IL1B
18 gastric cancer, hereditary diffuse 10.3 IL1B IL1RN
19 schnitzler syndrome 10.3 IL1B IL1RN
20 cerebral artery occlusion 10.3 IL1B IL1RN
21 osteosclerotic myeloma 10.3 IL1B IL1RN
22 acanthamoeba keratitis 10.3 F5 MBL2
23 inferior vena cava interruption 10.3 F5 SERPINE1
24 mevalonic aciduria 10.3 IL1B IL1RN
25 amaurosis fugax 10.2 F5 SERPINE1
26 livedoid vasculopathy 10.2 F5 SERPINE1
27 blood protein disease 10.2 PROC SERPINC1
28 root resorption 10.2 IL1A IL1B IL1RN
29 fibrinolytic defect 10.2 SERPINC1 SERPINE1
30 neisseria meningitidis infection 10.2 CFP IL1RN MBL2
31 cryptogenic cirrhosis 10.2 F5 SERPINE1
32 somatoform disorder 10.2 IL1A IL1B IL1RN
33 aggressive periodontitis 10.2 IL1A IL1B IL1RN
34 silicosis 10.2 IL1A IL1B IL1RN
35 osteomyelitis 10.2 IL1A IL1B IL1RN
36 bone inflammation disease 10.2 IL1A IL1B IL1RN
37 burns 10.2 IL1B SERPINC1
38 alopecia areata 10.2 IL1A IL1B IL1RN
39 vulvar vestibulitis syndrome 10.2 IL1B IL1RN MBL2
40 argentine hemorrhagic fever 10.2 SERPINC1 SERPINE1
41 vulvovaginal candidiasis 10.2 IL1RN MBL2
42 periodontal disease 10.1 IL1A IL1B IL1RN
43 blue toe syndrome 10.1 SERPINC1 SERPINE1
44 angina pectoris 10.1 SERPINC1 SERPINE1
45 quebec platelet disorder 10.1 F5 SERPINE1
46 subendocardial myocardial infarction 10.1 SERPINC1 SERPINE1
47 factor xiii deficiency 10.1 F5 SERPINE1
48 catastrophic antiphospholipid syndrome 10.1 F5 PROC SERPINE1
49 waterhouse-friderichsen syndrome 10.1
50 spinal cord infarction 10.1 F5 SERPINC1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia

Symptoms & Phenotypes for Meningococcemia

GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PROC SERPINC1 SERPINE1 THBD MBL2

MGI Mouse Phenotypes related to Meningococcemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 CFP F5 IL1A IL1B IL1RN PROC
2 hematopoietic system MP:0005397 9.85 THBD CCL5 IL1A IL1B IL1RN MBL2
3 homeostasis/metabolism MP:0005376 9.7 CFP F5 IL1A IL1B IL1RN MBL2
4 immune system MP:0005387 9.36 CFP IL1A IL1B IL1RN MBL2 PROC

Drugs & Therapeutics for Meningococcemia

Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
3
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
4 Cortisol succinate Phase 2
5 Hydrocortisone 17-butyrate 21-propionate Phase 2
6 Hydrocortisone acetate Phase 2
7 Hydrocortisone-17-butyrate Phase 2
8 Immunoglobulins Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Antibodies Phase 2
11
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
12 Calcitonin Gene-Related Peptide
13 calcitonin
14 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
2 Immunology and Safety of Menactra® in Children in Saudi Arabia Completed NCT00539032 Phase 3
3 Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents Completed NCT00777790 Phase 2
4 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children Completed NCT00771849 Phase 2
5 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
6 Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate Vaccine Completed NCT00772070 Phase 2
7 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study Completed NCT00732277 Phase 2 hydrocortisone
8 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Terminated NCT00772629 Phase 2
9 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
10 Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA. Recruiting NCT03378258

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

MalaCards organs/tissues related to Meningococcemia:

38
Bone, Testes, Skin, Atrioventricular Node, Endothelial, Heart, Colon

Publications for Meningococcemia

Articles related to Meningococcemia:

(show top 50) (show all 300)
# Title Authors Year
1
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
2
Fulminant meningococcemia. ( 28271045 )
2017
3
Fatal meningococcemia mimicking intra-abdominal emergency. ( 29260273 )
2017
4
Meningococcemia in vaccinated patient under treatment with eculizumab. ( 26994815 )
2017
5
No Neck Pain: Meningococcemia. ( 28821376 )
2017
6
A Case of Fulminant Meningococcemia: It Is All in the Complement. ( 28808592 )
2017
7
Purpura Fulminans in Acute Meningococcemia. ( 28236134 )
2017
8
Chronic meningococcemia in an immunocompetent child. ( 27535891 )
2016
9
Meningococcemia in Adults: A Review of the Literature. ( 26984070 )
2016
10
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. ( 27481255 )
2016
11
A rare case of chronic meningococcemia. ( 27728401 )
2016
12
Late Sequel of Meningococcemia: Skeletal Dysplasia. ( 26960252 )
2016
13
Meningococcemia Presenting as a Myocardial Infarction. ( 26640720 )
2015
14
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. ( 25970111 )
2015
15
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. ( 25825033 )
2015
16
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. ( 25420647 )
2015
17
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. ( 24977653 )
2014
18
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. ( 24577072 )
2014
19
Purpura fulminans caused by meningococcemia in an infant. ( 23921694 )
2013
20
Pathogenesis of meningococcemia. ( 23732856 )
2013
21
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. ( 24047748 )
2013
22
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. ( 23950664 )
2013
23
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. ( 23061921 )
2013
24
Meningococcemia: the pediatric orthopedic sequelae. ( 23622829 )
2013
25
Rash in meningococcemia. ( 22892518 )
2012
26
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. ( 23247497 )
2012
27
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. ( 22412064 )
2012
28
Meningococcemia presenting as acute painful mononeuritis multiplex. ( 22100105 )
2012
29
A baby with meningococcemia and septic shock. ( 22689868 )
2012
30
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. ( 22635194 )
2012
31
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. ( 21075588 )
2011
32
Fatal meningococcemia. ( 23882342 )
2011
33
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. ( 21459106 )
2011
34
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. ( 20844162 )
2010
35
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. ( 20841592 )
2010
36
Severe rhabdomyolysis associated in meningococcemia. ( 20927300 )
2010
37
Clinical images: Purpura fulminans caused by meningococcemia. ( 19858241 )
2010
38
Chronic meningococcemia in a 16-year-old boy: a case report. ( 19829911 )
2009
39
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. ( 19620896 )
2009
40
Giant condyloma with demise secondary to meningococcemia in an infant boy. ( 19596116 )
2009
41
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. ( 18657927 )
2009
42
Purpuric rash of meningococcemia. ( 18438796 )
2008
43
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
44
Meningococcemia without meningitis in Japan. ( 18758132 )
2008
45
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. ( 18559767 )
2008
46
Meningococcemia. ( 19384501 )
2008
47
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. ( 17276846 )
2007
48
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. ( 17697137 )
2007
49
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. ( 17569089 )
2007
50
Orchitis as a rare complication of meningococcemia in a young infant. ( 17387516 )
2007

Variations for Meningococcemia

Expression for Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for Meningococcemia

Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 F5 PROC PROCR SERPINC1 SERPINE1 THBD
2
Show member pathways
12.66 CCL5 IL1A IL1B IL1RN SERPINE1
3
Show member pathways
12.52 CCL5 CFP IL1A IL1B
4
Show member pathways
11.97 PROC PROCR THBD
5 11.9 IL1A IL1B IL1RN
6 11.81 IL1A IL1B THBD
7 11.68 IL1A IL1B SERPINE1
8
Show member pathways
11.63 F5 PROC PROCR SERPINC1 SERPINE1 THBD
9 11.55 IL1A IL1B SERPINE1 THBD
10 11.53 CCL5 IL1A IL1B
11 11.31 F5 MBL2 PROC PROCR SERPINC1 SERPINE1
12 11.15 CCL5 IL1A IL1B IL1RN
13 11.04 CCL5 IL1A IL1B
14 11.02 IL1A IL1B
15 10.21 IL1A IL1B

GO Terms for Meningococcemia

Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BPI CCL5 CFP F5 IL1A IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 CFP F5 PROC SERPINC1
3 extracellular space GO:0005615 9.4 BPI CCL5 CFP F5 IL1A IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 CCL5 IL1A IL1B IL1RN
2 immune response GO:0006955 9.8 BPI CCL5 CFP IL1A IL1B IL1RN
3 regulation of receptor activity GO:0010469 9.77 CCL5 IL1A IL1B IL1RN SERPINE1
4 positive regulation of angiogenesis GO:0045766 9.72 IL1A IL1B SERPINE1
5 leukocyte migration GO:0050900 9.71 IL1B PROC PROCR THBD
6 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B SERPINE1
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.57 IL1A IL1B
8 positive regulation of mitotic nuclear division GO:0045840 9.56 IL1A IL1B
9 blood coagulation GO:0007596 9.55 F5 PROC PROCR SERPINC1 THBD
10 positive regulation of monocyte chemotaxis GO:0090026 9.52 CCL5 SERPINE1
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.51 IL1A IL1B
12 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.49 IL1A IL1B
13 negative regulation of fibrinolysis GO:0051918 9.48 SERPINE1 THBD
14 negative regulation of coagulation GO:0050819 9.46 PROC PROCR
15 ectopic germ cell programmed cell death GO:0035234 9.43 IL1A IL1B
16 negative regulation of blood coagulation GO:0030195 9.43 PROC SERPINE1 THBD
17 fever generation GO:0001660 9.13 IL1A IL1B IL1RN
18 hemostasis GO:0007599 9.02 F5 PROC PROCR SERPINC1 THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CCL5 CFP F5 IL1A IL1B IL1RN
2 cytokine activity GO:0005125 9.26 CCL5 IL1A IL1B IL1RN
3 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN

Sources for Meningococcemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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