MCID: MNN021
MIFTS: 48

Meningococcemia malady

Rare diseases category

Summaries for Meningococcemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards: Meningococcemia is related to purpura and purpura fulminans. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cytokine Network. The compounds hirugen and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are embryogenesis and liver/biliary system.

Aliases & Classifications for Meningococcemia

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44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

meningococcemia 44 46 63


Related Diseases for Meningococcemia

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18GeneCards, 19GeneDecks
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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.0SERPINC1
2purpura fulminans30.7F5, PROCR, PROC, SERPINC1
3disseminated intravascular coagulation30.4THBD, SERPINE1, SERPINC1, LIF, PROC, F5
4complement deficiency30.2LIF, CFP
5arthritis30.1IL1A, IL1B
6thrombocytopenia30.1F5, IL1A, SERPINC1, THBD
7neisseria meningitidis infection29.9CFP, IL1RN
8tuberculosis29.9IL1B, BPI
9acute myocardial infarction29.8THBD, SERPINE1, SERPINC1, CCL5
10myocardial infarction29.8SERPINE1, SERPINC1, PROCR, CCL5, F5
11protein c deficiency29.7THBD, CFP, SERPINE1, SERPINC1, PROC, PROCR
12sepsis29.7THBD, SERPINE1, SERPINC1, PROC, PROCR, BPI
13septic shock29.6THBD, CFP, SERPINE1, SERPINC1, LIF, BPI
14meningitis10.5
15waterhouse-friderichsen syndrome10.4
16meningococcal meningitis10.3
17myocarditis10.1
18meningococcal infection10.1
19central retinal vein occlusion10.1F5
20sneddon syndrome10.1SERPINC1
21mediterranean spotted fever10.1THBD
22branch retinal artery occlusion10.1F5
23factor xi deficiency10.1F5
24periapical granuloma10.1CCL5
25degenerative disc disease10.1IL1B
26eclampsia10.1SERPINC1, THBD
27gastric cancer risk after h. pylori infection10.1IL1RN
28post-thrombotic syndrome10.1SERPINC1, F5
29legg-calve-perthes disease10.1SERPINC1, F5
30placental abruption10.1SERPINC1, F5
31prothrombin deficiency10.1F5, SERPINC1
32sagittal sinus thrombosis10.1SERPINC1, F5
33hepatic vein thrombosis10.1SERPINC1, F5
34retinal vein occlusion10.1F5, SERPINC1
35blood protein disease10.1SERPINC1, F5
36portal vein thrombosis10.1SERPINC1, F5
37antithrombin iii deficiency10.1SERPINC1, F5
38intracranial thrombosis10.1SERPINC1, F5
39factor xii deficiency10.1SERPINC1, F5
40mastitis10.1IL1B
41factor vii deficiency10.1SERPINC1, F5
42factor viii deficiency10.1SERPINC1, F5
43otitis media10.1IL1B
44afibrinogenemia10.1CFP, F5
45carotid artery thrombosis10.1SERPINE1
46dengue shock syndrome10.1IL1RN, THBD
47dysfibrinogenemia10.1THBD, SERPINC1, F5
48hemorrhagic disease10.1THBD, SERPINC1, F5
49pulmonary embolism10.1SERPINC1, F5
50idiopathic myopathy10.1CCL5, IL1A

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Meningococcemia

Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Search CenterWatch for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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34MalaCards
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MalaCards organs/tissues related to Meningococcemia:

34
Skin, Bone, Testes, Heart, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Meningococcemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F5, THBD, SERPINC1, LIF, PROCR
2MP:00053707.9F5, THBD, SERPINE1, SERPINC1, LIF, PROC
3MP:00107717.6F5, SERPINE1, LIF, IL1RN, THBD
4MP:00053787.2F5, THBD, SERPINE1, LIF, PROC, PROCR
5MP:00107686.2SERPINC1, CFP, SERPINE1, LIF, THBD, PROC
6MP:00053976.1SERPINC1, IL1B, THBD, IL1A, SERPINE1, PROC
7MP:00053856.0SERPINC1, F5, THBD, SERPINE1, LIF, PROC
8MP:00053875.8IL1B, CFP, SERPINE1, SERPINC1, LIF, THBD
9MP:00053765.7IL1RN, PROC, LIF, SERPINC1, SERPINE1, CFP

Publications for Meningococcemia

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Sources:
53PubMed
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Articles related to Meningococcemia:

(show top 50)    (show all 281)
idTitleAuthorsYear
1
Fatal meningococcemia. (23882342)
2011
2
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
3
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
4
Purpuric rash of meningococcemia. (18438796)
2008
5
Meningococcemia without meningitis in Japan. (18758132)
2008
6
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
7
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
11
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
12
Meningococcemia following tonsillectomy. (11868768)
2001
13
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
14
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
15
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
16
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
17
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
18
Treatment of purpura fulminans in meningococcemia with protein C concentrate. (7699550)
1995
19
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
20
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. (8399877)
1993
21
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
22
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia. (2320962)
1990
23
Post-trauma meningococcemia in C7 deficiency. (2401619)
1990
24
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia. (2585216)
1989
25
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
26
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
27
Chronic meningococcemia. (3123131)
1987
28
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
29
Chronic meningococcemia. (6523901)
1984
30
Myocardial dysfunction in children with acute meningococcemia. (6481530)
1984
31
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
32
Fulminant meningococcemia. (6944045)
1981
33
Chronic meningococcemia. (6772999)
1980
34
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
35
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
36
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
37
Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. (4925594)
1971
38
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971
39
Severe temporary deterioration of renal transplant function following meningococcemia. (5002590)
1971
40
Chronic meningococcemia. (4993239)
1970
41
Heparin therapy in fulminant meningococcemia. (5804192)
1969
42
Consumptive coagulopathy in fulminant meningococcemia. (5694791)
1968
43
Intravascular coagulation in fulminant meningococcemia. (4962442)
1967
44
Chronic meningococcemia. Report of a case. (14497365)
1962
45
Clinical staff conference on meningococcemia. (13518486)
1958
46
Chronic meningococcemia. (13340577)
1956
47
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 56Reactome, 55R&D Systems, 61Thomson Reuters
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Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LIF, THBD
29.4IL1B, IL1A
39.4IL1A, IL1B
49.4IL1B, IL1A
59.2CCL5, LIF, IL1B
6
Show member pathways
9.1F5, PROC, SERPINC1, THBD
79.1IL1B, CCL5, IL1A
89.1IL1B, IL1A, CCL5
9
Show member pathways
8.8IL1B, IL1RN, IL1A
10
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8SERPINE1, IL1B, CCL5
118.8IL1A, IL1RN, IL1B
12
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
8.8IL1A, IL1RN, IL1B
13
Show member pathways
8.7CFP, IL1B, CCL5, IL1A
14
Show member pathways
8.7IL1B, IL1A, LIF, CCL5
15
Show member pathways
8.7IL1A, IL1B, CCL5, LIF
16
Show member pathways
8.7LIF, IL1B, IL1A, CCL5
178.6SERPINE1, IL1B, IL1A
18
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.3PROC, F5, SERPINC1, SERPINE1, THBD
19
Show member pathways
8.3PROC, F5, THBD, SERPINE1, SERPINC1
20
Show member pathways
8.3THBD, SERPINE1, SERPINC1, PROC, F5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.0SERPINE1, IL1RN, IL1A, IL1B

Compounds for genes affiliated with Meningococcemia

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1hirugen469.9F5, SERPINC1, THBD
2ximelagatran46 1210.8THBD, SERPINC1, F5
3heparinoids469.8SERPINC1, F5, THBD
4fondaparinux469.7SERPINC1, THBD, F5
5gamma-carboxyglutamic acid469.6PROC, THBD, F5, PROCR
6bivalirudin46 1210.5F5, SERPINC1, THBD
7dermatan sulfate469.5THBD, CCL5, F5, SERPINC1
8warfarin46 52 25 1212.3SERPINC1, F5, PROC, THBD
9ancrod469.2THBD, SERPINE1, SERPINC1, F5
10desmopressin46 62 30 1212.1F5, THBD, SERPINE1, SERPINC1
11gm-csf46 3010.0CCL5, LIF, IL1A, IL1B
12raloxifene46 52 30 1212.0SERPINE1, THBD, F5, SERPINC1
13hirudin468.9SERPINE1, THBD, F5, PROCR, SERPINC1
14kininogen468.8THBD, SERPINC1, F5, SERPINE1
15polysaccharide468.8F5, BPI, LIF, SERPINC1, CFP, THBD
16polyethylene glycol468.8F5, IL1A, IL1RN, SERPINC1, THBD
17homocysteine46 259.8SERPINE1, F5, SERPINC1, THBD, CCL5
18pentoxifylline46 129.7IL1RN, THBD, IL1B, IL1A
19nacl468.7IL1RN, LIF, THBD, CCL5, F5
20calcitriol46 62 25 1211.6IL1A, IL1B, CCL5, THBD, LIF
21aprotinin46 129.6IL1A, SERPINC1, SERPINE1, THBD, F5
22neopterin468.5IL1RN, IL1A, IL1B, THBD
23lactate468.5LIF, BPI, CCL5, IL1RN, THBD, F5
24il 10468.4LIF, IL1RN, CCL5, IL1B, IL1A
25prostaglandin468.3IL1A, IL1B, IL1RN, LIF, CCL5
26pge1468.3IL1A, F5, IL1RN, SERPINE1, THBD
27fmlp468.2CCL5, IL1RN, BPI, LIF, IL1B, IL1A
28hydrocortisone46 3 62 1211.1LIF, IL1B, F5, IL1A, CCL5, IL1RN
29prostacyclin468.1SERPINC1, IL1B, F5, THBD, SERPINE1, IL1A
30pge2468.1IL1A, SERPINC1, LIF, CCL5, IL1RN, IL1B
31ascorbic acid46 259.0IL1RN, LIF, SERPINC1, CFP, THBD, IL1A
32simvastatin46 52 62 30 25 1213.0IL1A, IL1RN, CCL5, SERPINE1, THBD, F5
33actinomycin d467.9IL1B, IL1A, THBD, BPI, SERPINE1, LIF
34rantes467.9IL1B, IL1RN, CCL5, LIF, IL1A
35polymyxin b467.9BPI, IL1A, THBD, SERPINE1, IL1RN, IL1B
36cholesterol46 30 25 1210.7BPI, LIF, SERPINE1, THBD, CCL5, IL1RN
37aspirin46 52 30 2510.7F5, IL1B, IL1RN, CCL5, SERPINC1, SERPINE1
38sb 20358046 628.6IL1A, IL1B, IL1RN, LIF, SERPINE1, CCL5
39cysteine467.5IL1RN, CCL5, BPI, F5, CFP, LIF
40fibrinogen467.4SERPINE1, PROCR, F5, IL1RN, SERPINC1, LIF
41estrogen467.4THBD, CCL5, F5, SERPINC1, IL1RN, SERPINE1
42cycloheximide467.3IL1A, THBD, SERPINE1, LIF, CCL5, IL1RN
43dexamethasone46 52 30 1210.0IL1A, LIF, THBD, SERPINE1, IL1RN, SERPINC1
44creatinine467.0SERPINE1, F5, IL1RN, CCL5, BPI, IL1A
45retinoic acid46 257.7IL1A, THBD, SERPINE1, LIF, BPI, CCL5
46endotoxin466.5CCL5, IL1RN, THBD, F5, IL1A, IL1B
47nitric oxide46 25 128.5THBD, BPI, IL1RN, IL1B, IL1A, F5
48serine466.3THBD, F5, IL1A, SERPINC1, CCL5, BPI
49vegf466.2PROCR, LIF, SERPINC1, SERPINE1, THBD, BPI
50heparin46 30 25 129.2SERPINC1, LIF, PROC, BPI, CCL5, IL1RN

GO Terms for genes affiliated with Meningococcemia

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17Gene Ontology
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Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.9CFP, SERPINE1, SERPINC1, PROC, CCL5, IL1B
2extracellular spaceGO:0056155.6THBD, CFP, SERPINE1, SERPINC1, LIF, CCL5

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL5, IL1B
2protein kinase B signalingGO:0434919.7IL1B, CCL5
3ectopic germ cell programmed cell deathGO:0352349.7IL1B, IL1A
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7IL1A, IL1B
5positive regulation vascular endothelial growth factor productionGO:0105759.7IL1A, IL1B
6negative regulation of fibrinolysisGO:0519189.6THBD, SERPINE1
7positive regulation of monocyte chemotaxisGO:0900269.6CCL5, SERPINE1
8positive regulation of mitosisGO:0458409.6IL1B, IL1A
9cellular response to organic cyclic compoundGO:0714079.5IL1B, CCL5
10embryo implantationGO:0075669.5IL1B, LIF
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1A, IL1B
12extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4IL1A, IL1B
13positive regulation of interleukin-8 productionGO:0327579.3SERPINE1, IL1B
14negative regulation of blood coagulationGO:0301959.3THBD, SERPINE1, PROC
15fever generationGO:0016609.1IL1A, IL1RN, IL1B
16positive regulation of angiogenesisGO:0457668.9IL1A, IL1B, SERPINE1
17blood coagulationGO:0075968.4THBD, SERPINE1, SERPINC1, PROC, PROCR, F5
18positive regulation of transcription from RNA polymerase II promoterGO:0459447.9SERPINE1, LIF, IL1A, IL1B
19immune responseGO:0069557.8BPI, CFP, LIF, PROCR, IL1RN, IL1B

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1A, IL1B, LIF
2interleukin-1 receptor bindingGO:0051498.5IL1A, IL1B, IL1RN

Products for genes affiliated with Meningococcemia

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Meningococcemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet