Aliases & Classifications for Meningococcemia

MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 50 52 69

Classifications:



Summaries for Meningococcemia

MalaCards based summary : Meningococcemia is related to c4b deficiency and pericarditis. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-Like receptor Signaling Pathways. The drugs Vaccines and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 72 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Related Diseases for Meningococcemia

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
id Related Disease Score Top Affiliating Genes
1 c4b deficiency 30.2 CFP MBL2
2 pericarditis 28.2 F5 SERPINC1 SERPINE1 THBD
3 myocardial infarction 26.1 CCL5 F5 IL1B PROCR SERPINC1 SERPINE1
4 waterhouse-friderichsen syndrome 11.2
5 dengue disease 10.8
6 toxic optic neuropathy 10.7 IL1A IL1B
7 gout susceptibility 4 10.7 CFP MBL2
8 lymph node palisaded myofibroblastoma 10.6 IL1A MBL2
9 scrotal carcinoma 10.6 IL1A IL1B
10 prothrombin thrombophilia 10.6 IL1B MBL2
11 neuromyelitis optica 10.6 PROC SERPINE1
12 gliosarcoma 10.6 IL1A IL1B
13 mucositis 10.6 CFP MBL2
14 lung sarcoma 10.6 IL1A IL1B
15 gastric cancer risk after h. pylori infection 10.5 IL1B IL1RN
16 liver disease 10.5 IL1A IL1B
17 milk allergy 10.5 IL1B IL1RN
18 adams-oliver syndrome 10.5 CFP MBL2
19 accessory deep peroneal nerve 10.4 F5 MBL2
20 gastric cardia carcinoma 10.4 CFP MBL2
21 coronary sinus stenosis 10.4 F5 SERPINE1
22 indolent myeloma 10.4 IL1B IL1RN
23 amelogenesis imperfecta hypomaturation type 10.4 F5 SERPINE1
24 lockwood feingold syndrome 10.4 F5 SERPINE1
25 pulmonary embolism 10.4 CFP IL1B MBL2
26 glossitis 10.3 IL1A IL1B IL1RN
27 neonatal meningitis 10.3 CFP IL1RN MBL2
28 placenta accreta 10.3 IL1A IL1B IL1RN
29 sinusitis 10.3 IL1A IL1B IL1RN
30 autosomal recessive type iv ehlers-danlos syndrome 10.3 IL1A IL1B IL1RN
31 pleomorphic lipoma 10.3 IL1A IL1B IL1RN
32 mesenchymal cell neoplasm 10.3 IL1A IL1B IL1RN
33 cataract 10.3 IL1B SERPINC1
34 walker dyson syndrome 10.3 IL1B IL1RN MBL2
35 kaposi sarcoma 10.3 IL1A IL1B IL1RN
36 venezuelan hemorrhagic fever 10.3 SERPINC1 SERPINE1
37 inappropriate adh syndrome 10.3 IL1A IL1B IL1RN
38 midline cystocele 10.2 SERPINC1 SERPINE1
39 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.2 F5 SERPINE1
40 chronic diarrhea due to guanylate cyclase 2c overactivity 10.2 SERPINC1 SERPINE1
41 inferolateral myocardial infarct 10.2 SERPINC1 SERPINE1
42 meningitis 10.2
43 cavernous lymphangioma 10.2 F5 PROC SERPINE1
44 purpura 10.2
45 syncope 10.1 F5 SERPINC1
46 superior limbic keratoconjunctivitis 10.1 F5 SERPINC1
47 charcot-marie-tooth disease 10.1 F5 IL1B MBL2
48 testicular gonadoblastoma 10.1 F5 SERPINC1
49 osmotic diarrhea 10.1 IL1B IL1RN THBD
50 purpura fulminans 10.1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia

Symptoms & Phenotypes for Meningococcemia

GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 MBL2 PROC SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Meningococcemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 PROCR SERPINC1 SERPINE1 THBD CFP F5
2 hematopoietic system MP:0005397 9.85 CCL5 IL1A IL1B IL1RN MBL2 PROC
3 homeostasis/metabolism MP:0005376 9.7 CFP F5 IL1A IL1B IL1RN MBL2
4 immune system MP:0005387 9.36 CCL5 CFP IL1A IL1B IL1RN MBL2

Drugs & Therapeutics for Meningococcemia

Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
3
Butyric Acid Experimental Phase 2 107-92-6 264
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Anti-Inflammatory Agents Phase 2
7 Cortisol succinate Phase 2
8 Hydrocortisone 17-butyrate 21-propionate Phase 2
9 Hydrocortisone acetate Phase 2
10 Hydrocortisone-17-butyrate Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
2 Immunology and Safety of Menactra® in Children in Saudi Arabia Completed NCT00539032 Phase 3
3 Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents Completed NCT00777790 Phase 2
4 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children Completed NCT00771849 Phase 2
5 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
6 Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate Vaccine Completed NCT00772070 Phase 2
7 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study Completed NCT00732277 Phase 2 hydrocortisone
8 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Terminated NCT00772629 Phase 2
9 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

MalaCards organs/tissues related to Meningococcemia:

39
Skin, Bone, Testes, Atrioventricular Node, Endothelial, Colon, Heart

Publications for Meningococcemia

Articles related to Meningococcemia:

(show top 50) (show all 298)
id Title Authors Year
1
Meningococcemia in vaccinated patient under treatment with eculizumab. ( 26994815 )
2017
2
Purpura Fulminans in Acute Meningococcemia. ( 28236134 )
2017
3
A Case of Fulminant Meningococcemia: It Is All in the Complement. ( 28808592 )
2017
4
Fulminant meningococcemia. ( 28271045 )
2017
5
No Neck Pain: Meningococcemia. ( 28821376 )
2017
6
Chronic meningococcemia in an immunocompetent child. ( 27535891 )
2016
7
Meningococcemia in Adults: A Review of the Literature. ( 26984070 )
2016
8
A rare case of chronic meningococcemia. ( 27728401 )
2016
9
Late Sequel of Meningococcemia: Skeletal Dysplasia. ( 26960252 )
2016
10
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. ( 27481255 )
2016
11
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. ( 25970111 )
2015
12
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. ( 25420647 )
2015
13
Meningococcemia Presenting as a Myocardial Infarction. ( 26640720 )
2015
14
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. ( 25825033 )
2015
15
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. ( 24577072 )
2014
16
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. ( 24977653 )
2014
17
Meningococcemia: the pediatric orthopedic sequelae. ( 23622829 )
2013
18
Purpura fulminans caused by meningococcemia in an infant. ( 23921694 )
2013
19
Pathogenesis of meningococcemia. ( 23732856 )
2013
20
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. ( 23061921 )
2013
21
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. ( 23950664 )
2013
22
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. ( 24047748 )
2013
23
Meningococcemia presenting as acute painful mononeuritis multiplex. ( 22100105 )
2012
24
A baby with meningococcemia and septic shock. ( 22689868 )
2012
25
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. ( 23247497 )
2012
26
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. ( 22635194 )
2012
27
Rash in meningococcemia. ( 22892518 )
2012
28
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. ( 22412064 )
2012
29
Fatal meningococcemia. ( 23882342 )
2011
30
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. ( 21459106 )
2011
31
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. ( 21075588 )
2011
32
Clinical images: Purpura fulminans caused by meningococcemia. ( 19858241 )
2010
33
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. ( 20844162 )
2010
34
Severe rhabdomyolysis associated in meningococcemia. ( 20927300 )
2010
35
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. ( 20841592 )
2010
36
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. ( 18657927 )
2009
37
Chronic meningococcemia in a 16-year-old boy: a case report. ( 19829911 )
2009
38
Giant condyloma with demise secondary to meningococcemia in an infant boy. ( 19596116 )
2009
39
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. ( 19620896 )
2009
40
Purpuric rash of meningococcemia. ( 18438796 )
2008
41
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
42
Meningococcemia without meningitis in Japan. ( 18758132 )
2008
43
Meningococcemia. ( 19384501 )
2008
44
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. ( 18559767 )
2008
45
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. ( 17569089 )
2007
46
Orchitis as a rare complication of meningococcemia in a young infant. ( 17387516 )
2007
47
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. ( 17697137 )
2007
48
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. ( 17276846 )
2007
49
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. ( 17065145 )
2006
50
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. ( 16864696 )
2006

Variations for Meningococcemia

Expression for Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for Meningococcemia

Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 F5 PROC PROCR SERPINC1 SERPINE1 THBD
2
Show member pathways
12.67 CCL5 IL1A IL1B IL1RN SERPINE1
3
Show member pathways
12.59 CCL5 IL1B MBL2 SERPINE1
4
Show member pathways
12.53 CCL5 CFP IL1A IL1B
5
Show member pathways
11.98 PROC PROCR THBD
6 11.91 IL1A IL1B IL1RN
7 11.81 IL1A IL1B THBD
8 11.68 IL1A IL1B SERPINE1
9
Show member pathways
11.64 F5 PROC PROCR SERPINC1 SERPINE1 THBD
10 11.55 IL1A IL1B SERPINE1 THBD
11 11.53 CCL5 IL1A IL1B
12 11.31 F5 MBL2 PROC PROCR SERPINC1 SERPINE1
13 11.15 CCL5 IL1A IL1B IL1RN
14 11.04 CCL5 IL1A IL1B
15 11.03 IL1A IL1B
16 10.21 IL1A IL1B

GO Terms for Meningococcemia

Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BPI CCL5 CFP F5 IL1A IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 CFP F5 PROC SERPINC1
3 extracellular space GO:0005615 9.4 BPI CCL5 CFP F5 IL1A IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.83 CCL5 IL1A IL1B IL1RN
2 immune response GO:0006955 9.8 BPI CCL5 CFP IL1A IL1B IL1RN
3 positive regulation of angiogenesis GO:0045766 9.69 IL1A IL1B SERPINE1
4 leukocyte migration GO:0050900 9.67 IL1B PROC PROCR THBD
5 positive regulation of phagocytosis GO:0050766 9.58 IL1B MBL2
6 positive regulation of interleukin-8 production GO:0032757 9.57 IL1B SERPINE1
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.56 IL1A IL1B
8 positive regulation of mitotic nuclear division GO:0045840 9.55 IL1A IL1B
9 blood coagulation GO:0007596 9.55 F5 PROC PROCR SERPINC1 THBD
10 positive regulation of monocyte chemotaxis GO:0090026 9.54 CCL5 SERPINE1
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.49 IL1A IL1B
12 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.48 IL1A IL1B
13 negative regulation of fibrinolysis GO:0051918 9.46 SERPINE1 THBD
14 ectopic germ cell programmed cell death GO:0035234 9.43 IL1A IL1B
15 negative regulation of blood coagulation GO:0030195 9.43 PROC SERPINE1 THBD
16 negative regulation of coagulation GO:0050819 9.4 PROC PROCR
17 hemostasis GO:0007599 9.02 F5 PROC PROCR SERPINC1 THBD
18 fever generation GO:0001660 8.96 IL1A IL1B

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL5 IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN

Sources for Meningococcemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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