MCID: MNN021
MIFTS: 48

Meningococcemia malady

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Summaries for Meningococcemia

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Wikipedia:65 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to purpura and complement deficiency. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Cytokine Network. The compounds hirugen and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are embryogenesis and liver/biliary system.

Aliases & Classifications for Meningococcemia

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Meningococcemia, Aliases & Descriptions:

Name: Meningococcemia 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.6SERPINC1
2complement deficiency30.5LIF, CFP
3arthritis30.3IL1A, IL1B
4thrombocytopenia30.2SERPINC1, THBD, IL1A, F5
5neisseria meningitidis infection30.2CFP, IL1RN
6tuberculosis30.0IL1B, BPI
7disseminated intravascular coagulation29.9PROC, THBD, SERPINE1, LIF, F5, SERPINC1
8acute myocardial infarction29.8SERPINC1, SERPINE1, CCL5, THBD
9myocardial infarction29.6SERPINE1, SERPINC1, CCL5, F5, PROCR
10sepsis28.3IL1B, BPI, PROCR, PROC, SERPINC1, SERPINE1
11septic shock28.2F5, THBD, IL1B, IL1A, CFP, SERPINE1
12meningitis10.6
13central retinal vein occlusion10.5F5
14sneddon syndrome10.5SERPINC1
15mediterranean spotted fever10.5THBD
16branch retinal artery occlusion10.5F5
17factor xi deficiency10.5F5
18degenerative disc disease10.5IL1B
19periapical granuloma10.5CCL5
20eclampsia10.4THBD, SERPINC1
21waterhouse-friderichsen syndrome10.4
22gastric cancer risk after h. pylori infection10.4IL1RN
23post-thrombotic syndrome10.4F5, SERPINC1
24legg-calve-perthes disease10.4F5, SERPINC1
25placental abruption10.4SERPINC1, F5
26prothrombin deficiency10.4F5, SERPINC1
27sagittal sinus thrombosis10.4F5, SERPINC1
28hepatic vein thrombosis10.4SERPINC1, F5
29retinal vein occlusion10.4F5, SERPINC1
30meningococcal meningitis10.4
31blood protein disease10.4SERPINC1, F5
32intracranial thrombosis10.4F5, SERPINC1
33portal vein thrombosis10.4SERPINC1, F5
34antithrombin iii deficiency10.4F5, SERPINC1
35factor xii deficiency10.4F5, SERPINC1
36mastitis10.3IL1B
37factor vii deficiency10.3SERPINC1, F5
38factor viii deficiency10.3F5, SERPINC1
39otitis media10.3IL1B
40afibrinogenemia10.3CFP, F5
41carotid artery thrombosis10.3SERPINE1
42dengue shock syndrome10.3IL1RN, THBD
43dysfibrinogenemia10.3THBD, F5, SERPINC1
44hemorrhagic disease10.3THBD, SERPINC1, F5
45pulmonary embolism10.3SERPINC1, F5
46idiopathic myopathy10.3IL1A, CCL5
47oral lichen planus10.3IL1A, CCL5
48polymyalgia rheumatica10.2CCL5, IL1RN
49alcoholic hepatitis10.2IL1A, CCL5
50homocystinuria10.2F5, SERPINC1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

32
Skin, Bone, Testes, Heart, Endothelial, Atrioventricular node

Animal Models for Meningococcemia or affiliated genes

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MGI Mouse Phenotypes related to Meningococcemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F5, THBD, SERPINC1, LIF, PROCR
2MP:00053707.9F5, THBD, SERPINE1, SERPINC1, LIF, PROC
3MP:00107717.6F5, SERPINE1, LIF, IL1RN, THBD
4MP:00053787.2F5, THBD, SERPINE1, LIF, PROC, PROCR
5MP:00107686.2SERPINC1, CFP, SERPINE1, LIF, THBD, PROC
6MP:00053976.1SERPINC1, IL1B, THBD, IL1A, SERPINE1, PROC
7MP:00053856.0SERPINC1, F5, THBD, SERPINE1, LIF, PROC
8MP:00053875.8IL1B, CFP, SERPINE1, SERPINC1, LIF, THBD
9MP:00053765.7IL1RN, PROC, LIF, SERPINC1, SERPINE1, CFP

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Fatal meningococcemia. (23882342)
2011
2
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
3
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
4
Purpuric rash of meningococcemia. (18438796)
2008
5
Meningococcemia without meningitis in Japan. (18758132)
2008
6
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
7
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
8
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
9
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
10
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
11
Outcome in meningococcemia: a relationship between quantity and quality? (11588489)
2001
12
Meningococcemia following tonsillectomy. (11868768)
2001
13
Do new strategies in meningococcemia produce better outcomes? (11007200)
2000
14
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. (11090052)
2000
15
Abdominal pain and fever--an unusual presentation of meningococcemia. (10451180)
1999
16
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
17
Three phase bone imaging in a patient with fulminant meningococcemia. (9554208)
1998
18
Treatment of purpura fulminans in meningococcemia with protein C concentrate. (7699550)
1995
19
Assistive algorithms for exposure management--Part II: Mycobacterium tuberculosis, meningococcemia, and measles. (10135441)
1994
20
Purpura fulminans and adrenal hemorrhage due to group Y meningococcemia in an elderly woman. (1901668)
1991
21
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia. (2320962)
1990
22
Post-trauma meningococcemia in C7 deficiency. (2401619)
1990
23
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia. (2585216)
1989
24
Ultrasound diagnosis of adrenal hemorrhage in meningococcemia. (3050849)
1988
25
Once daily ceftriaxone for meningococcemia and meningococcal meningitis. (3054778)
1988
26
Chronic meningococcemia. (3123131)
1987
27
Benign meningococcemia with IgG and IgM antimeningococcal antibodies measured by ELISA. (3126548)
1987
28
Chronic meningococcemia. (6523901)
1984
29
Myocardial dysfunction in children with acute meningococcemia. (6481530)
1984
30
Amputation following meningococcemia. A sequela to purpura fulminans. (6705382)
1984
31
Fulminant meningococcemia. (6944045)
1981
32
Chronic meningococcemia. (6772999)
1980
33
Neonatal meningococcal meningitis and meningococcemia. (443224)
1979
34
Benign meningococcemia in childhood. A report of five cases with clinical and diagnostic remarks. (97774)
1978
35
Meningococcemia presenting as septic arthritis: case report. (4208724)
1974
36
Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. (4623015)
1972
37
Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. (4925594)
1971
38
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971
39
Severe temporary deterioration of renal transplant function following meningococcemia. (5002590)
1971
40
Chronic meningococcemia. (4993239)
1970
41
Heparin therapy in fulminant meningococcemia. (5804192)
1969
42
Consumptive coagulopathy in fulminant meningococcemia. (5694791)
1968
43
Intravascular coagulation in fulminant meningococcemia. (4962442)
1967
44
Chronic meningococcemia. Report of a case. (14497365)
1962
45
Clinical staff conference on meningococcemia. (13518486)
1958
46
Chronic meningococcemia. (13340577)
1956
47
Fulminating meningococcemia and meningitis with vascular collapse; report of a case of Waterhouse-Friderichsen syndrome with recovery. (14397040)
1955
48
Meningococcal infections; with particular reference to fulminating meningococcemia (Waterhouse-Friderichsen syndrome) treated with cortisone and norepinephrine. (13202023)
1954
49
Epidemic meningitis and meningococcemia treated with penicillin. (21012527)
1946
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Expression patterns in normal tissues for genes affiliated with Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LIF, THBD
29.4IL1B, IL1A
39.4IL1A, IL1B
49.4IL1B, IL1A
59.2CCL5, LIF, IL1B
6
Show member pathways
9.1F5, PROC, SERPINC1, THBD
79.1IL1B, CCL5, IL1A
89.1IL1B, IL1A, CCL5
9
Show member pathways
8.8IL1B, IL1RN, IL1A
10
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8SERPINE1, IL1B, CCL5
118.8IL1A, IL1RN, IL1B
12
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
8.8IL1A, IL1RN, IL1B
13
Show member pathways
8.7CFP, IL1B, CCL5, IL1A
14
Show member pathways
8.7IL1B, IL1A, LIF, CCL5
15
Show member pathways
8.7IL1A, IL1B, CCL5, LIF
16
Show member pathways
8.7LIF, IL1B, IL1A, CCL5
178.6SERPINE1, IL1B, IL1A
18
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.3PROC, F5, SERPINC1, SERPINE1, THBD
19
Show member pathways
8.3PROC, F5, THBD, SERPINE1, SERPINC1
20
Show member pathways
8.3THBD, SERPINE1, SERPINC1, PROC, F5
21
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.0SERPINE1, IL1RN, IL1A, IL1B

Compounds for genes affiliated with Meningococcemia

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Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1hirugen449.9F5, SERPINC1, THBD
2ximelagatran44 1110.8THBD, SERPINC1, F5
3heparinoids449.8SERPINC1, F5, THBD
4fondaparinux449.7SERPINC1, THBD, F5
5gamma-carboxyglutamic acid449.6PROC, THBD, F5, PROCR
6bivalirudin44 1110.5F5, SERPINC1, THBD
7dermatan sulfate449.5THBD, CCL5, F5, SERPINC1
8warfarin44 50 24 1112.3SERPINC1, F5, PROC, THBD
9ancrod449.2THBD, SERPINE1, SERPINC1, F5
10desmopressin44 61 28 1112.1F5, THBD, SERPINE1, SERPINC1
11gm-csf44 2810.0CCL5, LIF, IL1A, IL1B
12raloxifene44 50 28 1112.0SERPINE1, THBD, F5, SERPINC1
13hirudin448.9SERPINE1, THBD, F5, PROCR, SERPINC1
14kininogen448.8THBD, SERPINC1, F5, SERPINE1
15polysaccharide448.8F5, BPI, LIF, SERPINC1, CFP, THBD
16polyethylene glycol448.8F5, IL1A, IL1RN, SERPINC1, THBD
17homocysteine44 249.8SERPINE1, F5, SERPINC1, THBD, CCL5
18pentoxifylline44 119.7IL1RN, THBD, IL1B, IL1A
19nacl448.7IL1RN, LIF, THBD, CCL5, F5
20calcitriol44 61 24 1111.6IL1A, IL1B, CCL5, THBD, LIF
21aprotinin44 119.6IL1A, SERPINC1, SERPINE1, THBD, F5
22neopterin448.5IL1RN, IL1A, IL1B, THBD
23lactate448.5LIF, BPI, CCL5, IL1RN, THBD, F5
24il 10448.4LIF, IL1RN, CCL5, IL1B, IL1A
25prostaglandin448.3IL1A, IL1B, IL1RN, LIF, CCL5
26pge1448.3IL1A, F5, IL1RN, SERPINE1, THBD
27fmlp448.2CCL5, IL1RN, BPI, LIF, IL1B, IL1A
28hydrocortisone44 2 61 1111.1LIF, IL1B, F5, IL1A, CCL5, IL1RN
29prostacyclin448.1SERPINC1, IL1B, F5, THBD, SERPINE1, IL1A
30pge2448.1IL1A, SERPINC1, LIF, CCL5, IL1RN, IL1B
31ascorbic acid44 249.0IL1RN, LIF, SERPINC1, CFP, THBD, IL1A
32simvastatin44 50 61 28 24 1113.0IL1A, IL1RN, CCL5, SERPINE1, THBD, F5
33actinomycin d447.9IL1B, IL1A, THBD, BPI, SERPINE1, LIF
34rantes447.9IL1B, IL1RN, CCL5, LIF, IL1A
35polymyxin b447.9BPI, IL1A, THBD, SERPINE1, IL1RN, IL1B
36cholesterol44 28 24 1110.7BPI, LIF, SERPINE1, THBD, CCL5, IL1RN
37aspirin44 50 28 2410.7F5, IL1B, IL1RN, CCL5, SERPINC1, SERPINE1
38sb 20358044 618.6IL1A, IL1B, IL1RN, LIF, SERPINE1, CCL5
39cysteine447.5IL1RN, CCL5, BPI, F5, CFP, LIF
40fibrinogen447.4SERPINE1, PROCR, F5, IL1RN, SERPINC1, LIF
41estrogen447.4THBD, CCL5, F5, SERPINC1, IL1RN, SERPINE1
42cycloheximide447.3IL1A, THBD, SERPINE1, LIF, CCL5, IL1RN
43dexamethasone44 50 28 1110.0IL1A, LIF, THBD, SERPINE1, IL1RN, SERPINC1
44creatinine447.0SERPINE1, F5, IL1RN, CCL5, BPI, IL1A
45retinoic acid44 247.7IL1A, THBD, SERPINE1, LIF, BPI, CCL5
46endotoxin446.5CCL5, IL1RN, THBD, F5, IL1A, IL1B
47nitric oxide44 24 118.5THBD, BPI, IL1RN, IL1B, IL1A, F5
48serine446.3THBD, F5, IL1A, SERPINC1, CCL5, BPI
49vegf446.2PROCR, LIF, SERPINC1, SERPINE1, THBD, BPI
50heparin44 28 24 119.2SERPINC1, LIF, PROC, BPI, CCL5, IL1RN

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.9CFP, SERPINE1, SERPINC1, PROC, CCL5, IL1B
2extracellular spaceGO:0056155.6THBD, CFP, SERPINE1, SERPINC1, LIF, CCL5

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL5, IL1B
2protein kinase B signalingGO:0434919.7IL1B, CCL5
3ectopic germ cell programmed cell deathGO:0352349.7IL1B, IL1A
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7IL1A, IL1B
5positive regulation vascular endothelial growth factor productionGO:0105759.7IL1A, IL1B
6negative regulation of fibrinolysisGO:0519189.6THBD, SERPINE1
7positive regulation of monocyte chemotaxisGO:0900269.6CCL5, SERPINE1
8positive regulation of mitosisGO:0458409.6IL1B, IL1A
9cellular response to organic cyclic compoundGO:0714079.5IL1B, CCL5
10embryo implantationGO:0075669.5IL1B, LIF
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1A, IL1B
12extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4IL1A, IL1B
13positive regulation of interleukin-8 productionGO:0327579.3SERPINE1, IL1B
14negative regulation of blood coagulationGO:0301959.3THBD, SERPINE1, PROC
15fever generationGO:0016609.1IL1A, IL1RN, IL1B
16positive regulation of angiogenesisGO:0457668.9IL1A, IL1B, SERPINE1
17blood coagulationGO:0075968.4THBD, SERPINE1, SERPINC1, PROC, PROCR, F5
18positive regulation of transcription from RNA polymerase II promoterGO:0459447.9SERPINE1, LIF, IL1A, IL1B
19immune responseGO:0069557.8BPI, CFP, LIF, PROCR, IL1RN, IL1B

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1A, IL1B, LIF
2interleukin-1 receptor bindingGO:0051498.5IL1A, IL1B, IL1RN

Products for genes affiliated with Meningococcemia

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  • Antibodies
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Sources for Meningococcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet