MCID: MNN021
MIFTS: 39

Meningococcemia malady

Categories: Rare diseases

Aliases & Classifications for Meningococcemia

Aliases & Descriptions for Meningococcemia:

Name: Meningococcemia 50 52 69

Classifications:



Summaries for Meningococcemia

MalaCards based summary : Meningococcemia is related to c4b deficiency and pericarditis. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-Like receptor Signaling Pathways. The drugs Vaccines and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 71 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Related Diseases for Meningococcemia

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
id Related Disease Score Top Affiliating Genes
1 c4b deficiency 29.6 CFP MBL2
2 pericarditis 28.9 F5 SERPINC1 SERPINE1 THBD
3 myocardial infarction 28.2 CCL5 F5 IL1B PROCR SERPINC1 SERPINE1
4 waterhouse-friderichsen syndrome 11.2
5 neutropenia 10.3 PROC SERPINE1
6 toxic optic neuropathy 10.3 IL1A IL1B
7 pseudoainhum 10.3 IL1B MBL2
8 deafness, autosomal dominant 44 10.2 CFP MBL2
9 gout susceptibility 4 10.2 CFP MBL2
10 achard thiers syndrome 10.2 F5 MBL2
11 microglandular adenosis of breast 10.2 CFP IL1A
12 absence of innominate vein 10.2 F5 SERPINE1
13 meningitis 10.2
14 anal paget's disease 10.2 IL1A IL1B
15 aminoaciduria 10.2 F5 SERPINE1
16 lubinsky syndrome 10.2 F5 SERPINE1
17 hepatocellular carcinoma 10.2 IL1B IL1RN
18 egg allergy 10.2 IL1B IL1RN
19 warthin tumor 10.2 IL1B IL1RN MBL2
20 oral cavity carcinoma in situ 10.1 IL1B IL1RN MBL2
21 purpura 10.1
22 nephropathy familial with hyperuricemia 10.1 CFP IL1RN MBL2
23 glossitis 10.1 IL1A IL1B IL1RN
24 pulmonary eosinophilia 10.1 CFP IL1B MBL2
25 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1A IL1B IL1RN
26 testicular leydig cell tumor 10.1 IL1A IL1B IL1RN
27 mixed epithelial tumor of ovary 10.1 PROC SERPINC1
28 skin conditions 10.1 IL1A IL1B IL1RN
29 classic type lipoma 10.1 IL1A IL1B IL1RN
30 haemophilus meningitis 10.1 CFP MBL2
31 brazilian hemorrhagic fever 10.1 SERPINC1 SERPINE1
32 central congenital hypothyroidism 10.1 F5 PROC SERPINE1
33 bone angioendothelial sarcoma 10.1 IL1A IL1B IL1RN
34 intracranial hemorrhage in brain cerebrovascular malformations 10.1 IL1A IL1B IL1RN
35 histiocytosis 10.1 IL1A IL1B IL1RN
36 intratubular embryonal carcinoma 10.1 IL1A IL1B IL1RN
37 childhood type dermatomyositis 10.1 F5 IL1B MBL2
38 purpura fulminans 10.1
39 vascular erectile tumor 10.1 F5 SERPINC1
40 motility-related diarrhea 10.0 IL1B IL1RN THBD
41 pancreatic ductal carcinoma 10.0 F5 SERPINC1
42 dmd-related dilated cardiomyopathy 10.0 PROC PROCR SERPINC1
43 cataract 10.0 IL1B SERPINC1
44 disseminated intravascular coagulation 10.0
45 intracranial berry aneurysm 10.0 CFP MBL2
46 hypertrichosis 10.0 F5 SERPINC1
47 midline cystocele 10.0 SERPINC1 SERPINE1
48 ductal carcinoma in situ 10.0 PROC SERPINC1 THBD
49 stt3a-cdg and stt3b-cdg 10.0 F5 SERPINC1 SERPINE1
50 alcoholic gastritis 10.0 F5 PROC SERPINC1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia

Symptoms & Phenotypes for Meningococcemia

GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 MBL2 PROC SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Meningococcemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 CFP F5 IL1A IL1B IL1RN PROC
2 hematopoietic system MP:0005397 9.85 SERPINC1 SERPINE1 THBD CCL5 IL1A IL1B
3 homeostasis/metabolism MP:0005376 9.7 CFP F5 IL1A IL1B IL1RN MBL2
4 immune system MP:0005387 9.36 CCL5 CFP IL1A IL1B IL1RN MBL2

Drugs & Therapeutics for Meningococcemia

Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
3
Butyric Acid Experimental Phase 2 107-92-6 264
4 Cortisol succinate Phase 2
5 Hydrocortisone 17-butyrate 21-propionate Phase 2
6 Hydrocortisone acetate Phase 2
7 Hydrocortisone-17-butyrate Phase 2
8 Immunoglobulins Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
2 Immunology and Safety of Menactra® in Children in Saudi Arabia Completed NCT00539032 Phase 3
3 Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents Completed NCT00777790 Phase 2
4 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children Completed NCT00771849 Phase 2
5 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
6 Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate Vaccine Completed NCT00772070 Phase 2
7 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study Completed NCT00732277 Phase 2
8 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Terminated NCT00772629 Phase 2
9 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

MalaCards organs/tissues related to Meningococcemia:

39
Skin, Bone, Testes, Heart, Endothelial, Colon, Atrioventricular Node

Publications for Meningococcemia

Articles related to Meningococcemia:

(show top 50) (show all 293)
id Title Authors Year
1
Late Sequel of Meningococcemia: Skeletal Dysplasia. ( 26960252 )
2016
2
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. ( 27481255 )
2016
3
Meningococcemia in Adults: A Review of the Literature. ( 26984070 )
2016
4
Chronic meningococcemia in an immunocompetent child. ( 27535891 )
2016
5
A rare case of chronic meningococcemia. ( 27728401 )
2016
6
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. ( 25970111 )
2015
7
Meningococcemia Presenting as a Myocardial Infarction. ( 26640720 )
2015
8
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. ( 25825033 )
2015
9
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. ( 25420647 )
2015
10
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. ( 24577072 )
2014
11
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. ( 24977653 )
2014
12
Pathogenesis of meningococcemia. ( 23732856 )
2013
13
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. ( 23950664 )
2013
14
Purpura fulminans caused by meningococcemia in an infant. ( 23921694 )
2013
15
Meningococcemia: the pediatric orthopedic sequelae. ( 23622829 )
2013
16
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. ( 24047748 )
2013
17
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. ( 23061921 )
2013
18
Rash in meningococcemia. ( 22892518 )
2012
19
Meningococcemia presenting as acute painful mononeuritis multiplex. ( 22100105 )
2012
20
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. ( 23247497 )
2012
21
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. ( 22635194 )
2012
22
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. ( 22412064 )
2012
23
A baby with meningococcemia and septic shock. ( 22689868 )
2012
24
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. ( 21075588 )
2011
25
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. ( 21459106 )
2011
26
Fatal meningococcemia. ( 23882342 )
2011
27
Clinical images: Purpura fulminans caused by meningococcemia. ( 19858241 )
2010
28
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. ( 20841592 )
2010
29
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. ( 20844162 )
2010
30
Severe rhabdomyolysis associated in meningococcemia. ( 20927300 )
2010
31
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. ( 19620896 )
2009
32
Chronic meningococcemia in a 16-year-old boy: a case report. ( 19829911 )
2009
33
Giant condyloma with demise secondary to meningococcemia in an infant boy. ( 19596116 )
2009
34
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. ( 18657927 )
2009
35
Meningococcemia without meningitis in Japan. ( 18758132 )
2008
36
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
37
Meningococcemia. ( 19384501 )
2008
38
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. ( 18559767 )
2008
39
Purpuric rash of meningococcemia. ( 18438796 )
2008
40
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. ( 17697137 )
2007
41
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. ( 17276846 )
2007
42
Orchitis as a rare complication of meningococcemia in a young infant. ( 17387516 )
2007
43
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. ( 17569089 )
2007
44
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. ( 17065145 )
2006
45
Anterior uveitis and meningococcemia: a case report. ( 16766405 )
2006
46
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. ( 16864696 )
2006
47
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. ( 16510430 )
2006
48
Evolution of thrombin formation and fibrinolysis markers, including thrombin-activatable fibrinolysis inhibitor, during severe meningococcemia. ( 16772741 )
2005
49
Images in emergency medicine. Petechiae and purpura associated with meningococcemia. ( 15855959 )
2005
50
Meningococcemia update vaccination and chemoprophylaxis. ( 16085964 )
2005

Variations for Meningococcemia

Expression for Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for Meningococcemia

Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 F5 PROC PROCR SERPINC1 SERPINE1 THBD
2
Show member pathways
12.69 CCL5 IL1A IL1B IL1RN SERPINE1
3
Show member pathways
12.53 CCL5 CFP IL1A IL1B
4
Show member pathways
11.95 PROC PROCR THBD
5 11.9 IL1A IL1B IL1RN
6 11.81 IL1A IL1B THBD
7 11.68 IL1A IL1B SERPINE1
8
Show member pathways
11.64 F5 PROC PROCR SERPINC1 SERPINE1 THBD
9 11.55 IL1A IL1B SERPINE1 THBD
10 11.53 CCL5 IL1A IL1B
11 11.31 F5 MBL2 PROC PROCR SERPINC1 SERPINE1
12 11.15 CCL5 IL1A IL1B IL1RN
13 11.04 CCL5 IL1A IL1B
14 11.02 IL1A IL1B
15 10.21 IL1A IL1B

GO Terms for Meningococcemia

Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BPI CCL5 CFP F5 IL1A IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 CFP F5 PROC SERPINC1
3 extracellular space GO:0005615 9.4 BPI CCL5 CFP F5 IL1A IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 CCL5 IL1A IL1B IL1RN
2 immune response GO:0006955 9.73 BPI CCL5 CFP IL1A IL1B IL1RN
3 leukocyte migration GO:0050900 9.71 IL1B PROC PROCR THBD
4 positive regulation of angiogenesis GO:0045766 9.69 IL1A IL1B SERPINE1
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.58 IL1A IL1B
6 positive regulation of phagocytosis GO:0050766 9.58 IL1B MBL2
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.57 IL1A IL1B
8 positive regulation of mitotic nuclear division GO:0045840 9.56 IL1A IL1B
9 positive regulation of interleukin-8 production GO:0032757 9.55 IL1B SERPINE1
10 positive regulation of monocyte chemotaxis GO:0090026 9.52 CCL5 SERPINE1
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.49 IL1A IL1B
12 negative regulation of fibrinolysis GO:0051918 9.48 SERPINE1 THBD
13 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.46 IL1A IL1B
14 ectopic germ cell programmed cell death GO:0035234 9.43 IL1A IL1B
15 negative regulation of coagulation GO:0050819 9.37 PROC PROCR
16 blood coagulation GO:0007596 9.35 F5 PROC PROCR SERPINC1 THBD
17 negative regulation of blood coagulation GO:0030195 9.33 PROC SERPINE1 THBD
18 fever generation GO:0001660 9.32 IL1A IL1B
19 hemostasis GO:0007599 9.02 F5 PROC PROCR SERPINC1 THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL5 IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN

Sources for Meningococcemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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