MCID: MNN021
MIFTS: 32

Meningococcemia malady

Summaries for Meningococcemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards: Meningococcemia is related to meningitis and purpura. An important gene associated with Meningococcemia is PROCR (protein C receptor, endothelial), and among its related pathways are Platelet activation, signaling and aggregation and Senescence and Autophagy. The compounds hydrocortisone and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and liver/biliary system.

Aliases & Classifications for Meningococcemia

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

meningococcemia 42 44 60


Related Diseases for Meningococcemia

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17GeneCards, 18GeneDecks
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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis30.7IL1B, CFP
2purpura30.7SERPINC1
3complement deficiency30.5CFP, LIF
4disseminated intravascular coagulation30.5PROC, SERPINE1, THBD, F5, SERPINC1, LIF
5protein c deficiency30.1F5, PROCR, PROC, THBD, SERPINE1, SERPINC1
6herpes simplex30.0CCL5
7vasculitis30.0THBD, BPI
8thrombocytopenia30.0F5, THBD, SERPINC1, IL1A
9protein s deficiency30.0F5, SERPINE1, SERPINC1
10arthritis30.0IL1B, IL1A
11influenza29.8CCL5
12uveitis29.8IL1A
13proteinuria29.8CFP, CCL5
14antithrombin iii deficiency29.8F5, SERPINC1
15peritonitis29.8LIF, IL1B
16myeloma29.8IL1B, LIF
17neisseria meningitidis infection29.8CFP, IL1RN
18tuberculosis29.8IL1B, BPI
19leukemia29.8IL1B, LIF, IL1A
20acute myocardial infarction29.8SERPINC1, THBD, CCL5, SERPINE1
21myocardial infarction29.8CCL5, F5, SERPINC1, PROCR, SERPINE1
22waterhouse-friderichsen syndrome10.3
23myocarditis10.1
24osteonecrosis10.0
25septic arthritis10.0
26adult syndrome10.0
27hepatitis10.0
28ischemia10.0
29cystic fibrosis10.0BPI
30hemolytic-uremic syndrome10.0THBD
31nephrotic syndrome10.0SERPINC1
32polycythemia vera10.0THBD
33wegener's granulomatosis10.0BPI
34liver cirrhosis10.0SERPINC1
35atopy10.0CCL5
36hepatocellular carcinoma10.0CCL5
37allergic rhinitis10.0CCL5
38ovarian hyperstimulation syndrome10.0F5
39rhinitis10.0CCL5
40central retinal vein occlusion10.0F5
41primary pulmonary hypertension10.0THBD
42leukopenia10.0BPI
43bronchiolitis10.0CCL5
44branch retinal artery occlusion10.0F5
45sneddon syndrome10.0SERPINC1
46retinal vascular occlusion10.0F5
47infertility10.0LIF
48otitis media10.0IL1B
49pancreatitis10.0IL1B
50familial mediterranean fever10.0IL1B

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Clinical Features for Meningococcemia

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Drugs & Therapeutics for Meningococcemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Meningococcemia

Drug clinical trials:

Search ClinicalTrials for Meningococcemia

Search NIH Clinical Center for Meningococcemia

Search CenterWatch for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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Animal Models for Meningococcemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Meningococcemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0LIF, IL1RN, IL1A, IL1B, CFP
2MP:00053707.9PROC, LIF, THBD, SERPINE1, SERPINC1, F5
3MP:00053976.4CCL5, PROCR, PROC, LIF, IL1RN, IL1A
4MP:00107685.8F5, PROCR, PROC, LIF, IL1RN, IL1B
5MP:00053875.7SERPINC1, CCL5, PROCR, PROC, LIF, IL1RN
6MP:00053765.6F5, PROCR, PROC, LIF, IL1RN, IL1A

Publications for Meningococcemia

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Genetic Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 52R&D Systems
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Pathways related to Meningococcemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2THBD
29.7SERPINE1
39.6IL1A, CCL5
49.4IL1B, IL1A
59.2CCL5, LIF, IL1B
6
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9.1F5, PROC, THBD, SERPINC1
78.8IL1B, IL1A, IL1RN
8
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8.8IL1RN, IL1A, IL1B
9
Immune response Bacterial infections in normal airways
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8.8IL1B, IL1A, IL1RN
10
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8.8IL1RN, IL1A, IL1B
11
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8.7CCL5, IL1A, IL1B, CFP
12
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8.6IL1A, IL1B, SERPINE1
13
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8.3F5, PROC, THBD, SERPINE1, SERPINC1
14
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8.3SERPINC1, SERPINE1, THBD, PROC, F5
15
Hide members
8.3F5, PROC, THBD, SERPINE1, SERPINC1

Compounds for genes affiliated with Meningococcemia

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Meningococcemia according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.4LIF
2dexamethasone44 49 28 1113.1CCL5, LIF
3gm-csf44 2811.0CCL5, LIF
4warfarin44 49 11 2412.9PROC, SERPINC1
5hirugen449.9THBD, F5, SERPINC1
6ximelagatran44 1110.9SERPINC1, THBD, F5
7heparinoids449.9F5, SERPINC1, THBD
8fondaparinux449.8SERPINC1, F5, THBD
9bivalirudin44 1110.7F5, THBD, SERPINC1
10gamma-carboxyglutamic acid449.6THBD, F5, PROC, PROCR
11argatroban44 1110.5SERPINC1, THBD, F5
12dermatan sulfate449.5F5, SERPINC1, THBD, CCL5
13raloxifene44 28 49 1112.3SERPINE1, SERPINC1, F5
14Drotrecogin alfa119.2F5, SERPINE1, PROCR, THBD
15kininogen449.2F5, SERPINC1, SERPINE1
16ancrod449.2SERPINE1, THBD, SERPINC1, F5
17aprotinin44 1110.1SERPINC1, THBD, F5, SERPINE1
18prostaglandin449.1IL1B, IL1RN, IL1A
19desmopressin44 59 28 1112.1F5, SERPINE1, SERPINC1, THBD
20nacl449.0LIF, THBD, IL1RN, F5
21hirudin448.9THBD, SERPINE1, SERPINC1, F5, PROCR
22creatinine448.9THBD, IL1RN, F5, BPI, IL1A
23rantes448.9LIF, IL1B, IL1A
24thalidomide44 49 59 1111.8THBD, IL1A, CCL5, IL1B
25polysaccharide448.8LIF, BPI, F5, THBD, SERPINC1, CFP
26polyethylene glycol448.8THBD, IL1RN, IL1A, F5, SERPINC1
27pentoxifylline44 119.8IL1A, IL1B, IL1RN, THBD
28homocysteine44 249.8SERPINC1, SERPINE1, THBD, F5, CCL5
29serine448.7LIF, PROCR, IL1A, IL1RN, CCL5
30calcitriol44 59 11 2411.6IL1A, LIF, IL1B, THBD, CCL5
31neopterin448.6IL1B, THBD, IL1A, IL1RN
32endotoxin448.5SERPINE1, PROCR, THBD, F5, BPI, LIF
33il 10448.4IL1RN, IL1B, IL1A, CCL5, LIF
34lactate448.4THBD, IL1RN, CCL5, BPI, LIF, F5
35heparin44 28 11 2411.4CCL5, BPI, LIF, IL1RN, IL1A, CFP
36pge1448.3F5, THBD, SERPINE1, IL1RN, IL1A
37fmlp448.2IL1RN, IL1A, IL1B, LIF, CCL5, BPI
38prostacyclin448.1THBD, F5, IL1A, SERPINC1, SERPINE1, IL1B
39ascorbic acid44 249.0SERPINC1, F5, IL1RN, IL1A, CFP, THBD
40simvastatin44 49 59 28 11 2413.0IL1A, IL1RN, SERPINE1, THBD, F5, CCL5
41actinomycin d447.9IL1A, IL1B, THBD, BPI, SERPINE1, LIF
42polymyxin b447.9IL1A, BPI, IL1RN, IL1B, THBD, SERPINE1
43ribonucleic acid447.7CCL5, LIF, IL1RN, IL1B, IL1A
44cholesterol44 28 11 2410.7THBD, LIF, SERPINE1, BPI, CCL5, F5
45aspirin44 49 28 2410.7CCL5, SERPINC1, IL1RN, IL1B, THBD, SERPINE1
46sb 20358044 598.6SERPINE1, CCL5, IL1B, IL1A, IL1RN, LIF
47fibrinogen447.4PROC, IL1RN, LIF, SERPINE1, SERPINC1, THBD
48retinoic acid44 247.7LIF, IL1RN, BPI, SERPINE1, IL1A, F5
49nitric oxide44 11 248.5IL1A, IL1RN, PROCR, F5, CCL5, SERPINE1
50vegf446.2CCL5, BPI, SERPINE1, F5, PROCR, LIF

GO Terms for genes affiliated with Meningococcemia

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16Gene Ontology
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Cellular components related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.6CCL5, F5, PROC, IL1A, IL1B, CFP
2extracellular spaceGO:0056155.9SERPINC1, CCL5, F5, LIF, IL1RN, IL1A

Biological processes related to Meningococcemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.6IL1A, IL1B
2negative regulation of fibrinolysisGO:0519189.5SERPINE1, THBD
3positive regulation of interleukin-2 biosynthetic processGO:0450869.4IL1A, IL1B
4negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, IL1A
5positive regulation of monocyte chemotaxisGO:0900269.4SERPINE1, CCL5
6positive regulation vascular endothelial growth factor productionGO:0105759.3IL1B, IL1A
7negative regulation of blood coagulationGO:0301959.2SERPINE1, THBD, PROC
8positive regulation of interleukin-8 productionGO:0327578.8SERPINE1, IL1B
9positive regulation of angiogenesisGO:0457668.8SERPINE1, IL1B, IL1A
10blood coagulationGO:0075968.3F5, PROCR, PROC, THBD, SERPINE1, SERPINC1
11immune responseGO:0069557.7CFP, BPI, PROCR, LIF, IL1RN, IL1A

Molecular functions related to Meningococcemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL1B, IL1A, LIF
2interleukin-1 receptor bindingGO:0051498.5IL1B, IL1A, IL1RN

Products for genes affiliated with Meningococcemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Meningococcemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet