MCID: MNN021
MIFTS: 39

Meningococcemia malady

Category: Rare diseases

Aliases & Classifications for Meningococcemia

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Aliases & Descriptions for Meningococcemia:

Name: Meningococcemia 48 50 68

Classifications:



Summaries for Meningococcemia

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Wikipedia:71 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

MalaCards based summary: Meningococcemia is related to c4b deficiency and pericarditis. An important gene associated with Meningococcemia is BPI (Bactericidal/Permeability-Increasing Protein), and among its related pathways are Cytokines and Inflammatory Response and Interleukin-1 processing. Affiliated tissues include skin, bone and testes, and related mouse phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system.

Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1c4b deficiency29.6CFP, MBL2
2pericarditis28.9F5, SERPINC1, SERPINE1, THBD
3myocardial infarction28.2CCL5, F5, IL1B, PROCR, SERPINC1, SERPINE1
4waterhouse-friderichsen syndrome11.2
5neutropenia10.3PROC, SERPINE1
6toxic optic neuropathy10.3IL1A, IL1B
7pseudoainhum10.3IL1B, MBL2
8deafness, autosomal dominant 4410.2CFP, MBL2
9gout susceptibility 410.2CFP, MBL2
10achard thiers syndrome10.2F5, MBL2
11microglandular adenosis of breast10.2CFP, IL1A
12absence of innominate vein10.2F5, SERPINE1
13meningitis10.2
14anal paget's disease10.2IL1A, IL1B
15aminoaciduria10.2F5, SERPINE1
16lubinsky syndrome10.2F5, SERPINE1
17hepatocellular carcinoma10.2IL1B, IL1RN
18egg allergy10.2IL1B, IL1RN
19warthin tumor10.2IL1B, IL1RN, MBL2
20oral cavity carcinoma in situ10.1IL1B, IL1RN, MBL2
21purpura10.1
22nephropathy familial with hyperuricemia10.1CFP, IL1RN, MBL2
23glossitis10.1IL1A, IL1B, IL1RN
24pulmonary eosinophilia10.1CFP, IL1B, MBL2
25autosomal recessive type iv ehlers-danlos syndrome10.1IL1A, IL1B, IL1RN
26testicular leydig cell tumor10.1IL1A, IL1B, IL1RN
27mixed epithelial tumor of ovary10.1PROC, SERPINC1
28skin conditions10.1IL1A, IL1B, IL1RN
29classic type lipoma10.1IL1A, IL1B, IL1RN
30haemophilus meningitis10.1CFP, MBL2
31brazilian hemorrhagic fever10.1SERPINC1, SERPINE1
32central congenital hypothyroidism10.1F5, PROC, SERPINE1
33bone angioendothelial sarcoma10.1IL1A, IL1B, IL1RN
34intracranial hemorrhage in brain cerebrovascular malformations10.1IL1A, IL1B, IL1RN
35histiocytosis10.1IL1A, IL1B, IL1RN
36intratubular embryonal carcinoma10.1IL1A, IL1B, IL1RN
37childhood type dermatomyositis10.1F5, IL1B, MBL2
38purpura fulminans10.1
39vascular erectile tumor10.1F5, SERPINC1
40motility-related diarrhea10.0IL1B, IL1RN, THBD
41pancreatic ductal carcinoma10.0F5, SERPINC1
42dmd-related dilated cardiomyopathy10.0PROC, PROCR, SERPINC1
43cataract10.0IL1B, SERPINC1
44disseminated intravascular coagulation10.0
45intracranial berry aneurysm10.0CFP, MBL2
46hypertrichosis10.0F5, SERPINC1
47midline cystocele10.0SERPINC1, SERPINE1
48ductal carcinoma in situ10.0PROC, SERPINC1, THBD
49stt3a-cdg and stt3b-cdg10.0F5, SERPINC1, SERPINE1
50alcoholic gastritis10.0F5, PROC, SERPINC1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to meningococcemia

Symptoms & Phenotypes for Meningococcemia

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GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00362-A8.5MBL2, PROC, SERPINC1, SERPINE1, THBD

MGI Mouse Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.1CFP, F5, IL1A, IL1B, IL1RN, PROC
2MP:00053976.9CCL5, IL1A, IL1B, IL1RN, MBL2, PROC
3MP:00053766.8CFP, F5, IL1A, IL1B, IL1RN, MBL2
4MP:00053876.4CCL5, CFP, IL1A, IL1B, IL1RN, MBL2

Drugs & Therapeutics for Meningococcemia

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Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 3, Phase 26611
2
Hydrocortisoneapproved, vet_approvedPhase 266750-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
3
Butyric AcidexperimentalPhase 2380107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
1-propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
Butyric acid
 
Butyricum acidum
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
N-butanoic acid
N-butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
4Hydrocortisone acetatePhase 2667
5Hydrocortisone-17-butyratePhase 2332
6Hydrocortisone 17-butyrate 21-propionatePhase 2667
7AntibodiesPhase 26394
8ImmunoglobulinsPhase 26394
9Cortisol succinatePhase 2667
10Anti-Inflammatory AgentsPhase 210729

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap VaccineCompletedNCT00777257Phase 4
2Immunology and Safety of Menactra® in Children in Saudi ArabiaCompletedNCT00539032Phase 3
3Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in AdolescentsCompletedNCT00777790Phase 2
4Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in ChildrenCompletedNCT00771849Phase 2
5Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26CompletedNCT00700713Phase 2
6Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate VaccineCompletedNCT00772070Phase 2
7Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot StudyCompletedNCT00732277Phase 2
8Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy AdultsTerminatedNCT00772629Phase 2
9Correlation Between Cytokines and the Severity of Meningococcal DiseaseCompletedNCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

36
Skin, Bone, Testes, Atrioventricular node, Endothelial, Colon, Heart

Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Late Sequel of Meningococcemia: Skeletal Dysplasia. (26960252)
2016
2
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. (27481255)
2016
3
Meningococcemia in Adults: A Review of the Literature. (26984070)
2016
4
Chronic meningococcemia in an immunocompetent child. (27535891)
2016
5
A rare case of chronic meningococcemia. (27728401)
2016
6
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. (25970111)
2015
7
Meningococcemia Presenting as a Myocardial Infarction. (26640720)
2015
8
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. (25825033)
2015
9
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. (25420647)
2015
10
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. (24577072)
2014
11
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. (24977653)
2014
12
Pathogenesis of meningococcemia. (23732856)
2013
13
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. (23950664)
2013
14
Purpura fulminans caused by meningococcemia in an infant. (23921694)
2013
15
Meningococcemia: the pediatric orthopedic sequelae. (23622829)
2013
16
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. (24047748)
2013
17
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. (23061921)
2013
18
Rash in meningococcemia. (22892518)
2012
19
Meningococcemia presenting as acute painful mononeuritis multiplex. (22100105)
2012
20
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. (23247497)
2012
21
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. (22635194)
2012
22
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. (22412064)
2012
23
A baby with meningococcemia and septic shock. (22689868)
2012
24
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. (21075588)
2011
25
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. (21459106)
2011
26
Fatal meningococcemia. (23882342)
2011
27
Clinical images: Purpura fulminans caused by meningococcemia. (19858241)
2010
28
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. (20841592)
2010
29
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. (20844162)
2010
30
Severe rhabdomyolysis associated in meningococcemia. (20927300)
2010
31
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. (19620896)
2009
32
Chronic meningococcemia in a 16-year-old boy: a case report. (19829911)
2009
33
Giant condyloma with demise secondary to meningococcemia in an infant boy. (19596116)
2009
34
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. (18657927)
2009
35
Meningococcemia without meningitis in Japan. (18758132)
2008
36
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. (18516063)
2008
37
Meningococcemia. (19384501)
2008
38
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. (18559767)
2008
39
Purpuric rash of meningococcemia. (18438796)
2008
40
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. (17697137)
2007
41
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. (17276846)
2007
42
Orchitis as a rare complication of meningococcemia in a young infant. (17387516)
2007
43
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. (17569089)
2007
44
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. (17065145)
2006
45
Anterior uveitis and meningococcemia: a case report. (16766405)
2006
46
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. (16864696)
2006
47
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia. (16510430)
2006
48
Evolution of thrombin formation and fibrinolysis markers, including thrombin-activatable fibrinolysis inhibitor, during severe meningococcemia. (16772741)
2005
49
Images in emergency medicine. Petechiae and purpura associated with meningococcemia. (15855959)
2005
50
Meningococcemia update vaccination and chemoprophylaxis. (16085964)
2005

Variations for Meningococcemia

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Expression for genes affiliated with Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.

Pathways for genes affiliated with Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL1A, IL1B
29.8IL1A, IL1B
39.5IL1A, IL1B, SERPINE1
49.4IL1A, IL1B, IL1RN
59.3IL1A, IL1B, THBD
6
Show member pathways
9.2PROC, PROCR, THBD
79.0CCL5, IL1A, IL1B
89.0CCL5, IL1A, IL1B
99.0IL1A, IL1B, SERPINE1, THBD
10
Show member pathways
8.6CCL5, CFP, IL1A, IL1B
118.6CCL5, IL1A, IL1B, IL1RN
12
Show member pathways
8.3CCL5, IL1A, IL1B, IL1RN, SERPINE1
13
Show member pathways
7.7F5, PROC, PROCR, SERPINC1, SERPINE1, THBD
14
Show member pathways
7.7F5, PROC, PROCR, SERPINC1, SERPINE1, THBD
15
Show member pathways
7.5F5, MBL2, PROC, PROCR, SERPINC1, SERPINE1

GO Terms for genes affiliated with Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.5CFP, F5, PROC, SERPINC1
2extracellular regionGO:00055766.2BPI, CCL5, CFP, F5, IL1A, IL1B
3extracellular spaceGO:00056155.4BPI, CCL5, CFP, F5, IL1A, IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.6IL1A, IL1B
2extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.6IL1A, IL1B
3fever generationGO:000166010.6IL1A, IL1B
4positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
5negative regulation of coagulationGO:005081910.3PROC, PROCR
6positive regulation of interleukin-8 productionGO:003275710.3IL1B, SERPINE1
7positive regulation of mitotic nuclear divisionGO:004584010.3IL1A, IL1B
8positive regulation of monocyte chemotactic protein-1 productionGO:007163910.3IL1A, IL1B
9positive regulation of phagocytosisGO:005076610.2IL1B, MBL2
10negative regulation of fibrinolysisGO:005191810.2SERPINE1, THBD
11positive regulation of angiogenesisGO:004576610.1IL1A, IL1B, SERPINE1
12negative regulation of blood coagulationGO:003019510.0PROC, SERPINE1, THBD
13positive regulation of vascular endothelial growth factor productionGO:00105759.8IL1A, IL1B
14positive regulation of monocyte chemotaxisGO:00900269.8CCL5, SERPINE1
15leukocyte migrationGO:00509009.5IL1B, PROC, PROCR, THBD
16inflammatory responseGO:00069549.3CCL5, IL1A, IL1B, IL1RN
17blood coagulationGO:00075968.8F5, PROC, PROCR, SERPINC1, THBD
18hemostasisGO:00075998.8F5, PROC, PROCR, SERPINC1, THBD
19immune responseGO:00069558.7BPI, CCL5, CFP, IL1A, IL1B, IL1RN

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.4IL1A, IL1B, IL1RN
2cytokine activityGO:00051258.9CCL5, IL1A, IL1B, IL1RN

Sources for Meningococcemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet