MCID: MNN009
MIFTS: 46

Meningoencephalitis malady

Neuronal diseases category
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Summaries for Meningoencephalitis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Meningoencephalitis (/m??n????.?n?s?f??la?t?s/; from Greek: meninges- membranes; enkephalos brain; and... more...

MalaCards: Meningoencephalitis is related to encephalitis and myositis. An important gene associated with Meningoencephalitis is C9 (complement component 9), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds ptca and cerivastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and skin, and related mouse phenotype immune system.

Disease Ontology:8 A central nervous system disease that involves encephalitis which occurs along with meningitis.

Aliases & Classifications for Meningoencephalitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

meningoencephalitis 8 10 45 62


External Ids:

Disease Ontology8 DOID:10554
NCIt40 C34813
SNOMED-CT58 7125002
MeSH35 D008590

Related Diseases for Meningoencephalitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to meningoencephalitis

Symptoms for Meningoencephalitis

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Drugs & Therapeutics for Meningoencephalitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Meningoencephalitis

Search NIH Clinical Center for Meningoencephalitis

Genetic Tests for Meningoencephalitis

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Anatomical Context for Meningoencephalitis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Meningoencephalitis:

33
Brain, Pituitary, Skin, Kidney, T cells, Testes, B cells, Thyroid, Spinal cord, Endothelial

Animal Models for Meningoencephalitis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Meningoencephalitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1C5, CCL5, APP, DARC

Publications for Meningoencephalitis

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Sources:
52PubMed
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Articles related to Meningoencephalitis:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Acute phenytoin intoxication in a 4-year-old mimicking viral meningoencephalitis. (23814089)
2013
2
Establishment of a model of Streptococcus iniae meningoencephalitis in Nile tilapia (Oreochromis niloticus). (23218409)
2013
3
Retrospective study of Mycoplasma gallisepticum meningoencephalitis in six turkey flocks in western France. (22878056)
2013
4
Aseptic meningoencephalitis mimicking transient ischaemic attacks. (23325395)
2013
5
Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. (23599314)
2013
6
Complete genome sequence of Streptococcus agalactiae strain SA20-06, a fish pathogen associated to meningoencephalitis outbreaks. (23991251)
2013
7
Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis. (23025483)
2012
8
Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta). (23114049)
2012
9
Pituitary tumor apoplexy presenting as infective meningoencephalitis. (21630035)
2012
10
Long-term immunosuppressive therapy with cyclosporine plus prednisolone for necrotizing meningoencephalitis in a Pekingese dog. (22214856)
2012
11
HHV6 meningoencephalitis sequelae in previously healthy children. (22802100)
2012
12
A rare case of survival from primary amebic meningoencephalitis. (22557831)
2012
13
Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage. (21975129)
2011
14
Tick-borne meningoencephalitis in a 4.5-month-old infant. (20814849)
2011
15
Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. (22051026)
2011
16
Thrombotic thrombocytopenic purpura mimicking an acute meningoencephalitis. (21485766)
2011
17
Onset of meningoencephalitis: disseminated candidiasis. (22181574)
2011
18
Meningoencephalitis associated with hepatitis A infection: a case report and review of literature. (20555050)
2010
19
Pathology in practice. Necrotizing pyogranulomatous meningoencephalitis with intralesional fungal hyphae, consistent with Cladophialophora bantiana. (20113240)
2010
20
Primary amoebic meningoencephalitis: first reported case from Rohtak, North India. (20191204)
2009
21
The rationale for integrated childhood meningoencephalitis surveillance: a case study from Cambodia. (19551241)
2009
22
Update on emerging infections: News from the Centers for Disease Control and Prevention. Primary amebic meningoencephalitis-Arizona, Florida, and Texas, 2007. (19708086)
2009
23
A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant. (18463893)
2009
24
Cogan's syndrome: a rare cause of meningoencephalitis. (19491118)
2009
25
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs. (19645838)
2009
26
Treatment of meningoencephalitis of unknown origin in a dog. (19448257)
2009
27
Necrotizing meningoencephalitis in five Chihuahua dogs. (18487490)
2008
28
Meningoencephalitis associated with human parvovirus B19. (19076847)
2008
29
Meningoencephalitis due to Toscana virus in a French traveler returning from central Italy. (19006512)
2008
30
sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis. (18813709)
2008
31
Regression of white matter MRI abnormalities in nonvasculitic autoimmune inflammatory meningoencephalitis following intravenous immunoglobulin. (17389804)
2007
32
Anthrax meningoencephalitis successfully treated. (17661992)
2007
33
Non-suppurative meningoencephalitis of unknown origin in cats and dogs: an immunohistochemical study. (17275833)
2007
34
Virological and immunological characteristics of fatal Epstein-Barr virus mononucleosis in a 17-year-old Caucasian male presenting with meningoencephalitis and hemophagocytic syndrome. (17849323)
2007
35
Ventricular pneumocephalus and septic meningoencephalitis secondary to dorsal rhinotomy and nasal polypectomy in a dog. (16842045)
2006
36
Acute meningoencephalitis caused by adenovirus serotype 26. (16877305)
2006
37
Meningoencephalitis associated with Staphylococcus warneri in a dog. (17004952)
2006
38
Tickborne meningoencephalitis, first case after 19 years in northeastern Germany. (15834983)
2005
39
Pyogranulomatous meningoencephalitis in a goat due to Corynebacterium ulcerans. (15786922)
2005
40
Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. (15862291)
2005
41
Pathologic quiz case: headache in an 8-year-old child. Primary amebic meningoencephalitis due to Naegleria fowleri. (14736265)
2004
42
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. (12805119)
2003
43
Primary amebic meningoencephalitis--Georgia, 2002. (14534512)
2003
44
Intrathecal humoral immune response in pediatric patients with meningoencephalitis due to Coxsackie B5]. (10363312)
1999
45
From the Centers for Disease Control. Primary amebic meningoencephalitis--North Carolina, 1991. (1640602)
1992
46
Herpes zoster ophthalmicus with delayed cerebral infarction and meningoencephalitis. (3311326)
1987
47
Coxsackievirus B3 producing fatal meningoencephalitis in a patient with X-linked agammaglobulinemia. (6293302)
1983
48
Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. (1259085)
1976
49
Primary amebic meningoencephalitis. (4620947)
1972
50
Mumps meningoencephalitis with and without parotitis. (18147966)
1949

Variations for Meningoencephalitis

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Expression for genes affiliated with Meningoencephalitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for genes affiliated with Meningoencephalitis

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 60Thomson Reuters, 57SinoBiological
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Pathways related to Meningoencephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CCL5, APP
2
Show member pathways
9.5CCL5, APP
3
Show member pathways
9.4CCL5, DARC
4
Show member pathways
9.2C9, C5
5
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.2C5, C9
6
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.2C5, C9
78.8C9, CCL5, C5
8
Show member pathways
8.7C9, APP, C5
9
Show member pathways
8.1C5, CCL5, APP, DARC
10
Show member pathways
8.1C5, DARC, APP, CCL5

Compounds for genes affiliated with Meningoencephalitis

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Meningoencephalitis according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1ptca459.8CCL5, CHKB
2cerivastatin51 45 29 1112.8CHKB, CCL5
3propranolol45 29 51 24 1113.8CCL5, APP
4risperidone45 51 29 61 24 1114.8APP, CHKB
5azathioprine45 3 51 1112.7CHKB, CCL5
6lead459.7CCL5, CHKB
7lovastatin45 51 61 29 1113.7APP, CHKB
8gf 109203x45 6110.6APP, CCL5
9egcg459.6APP, CCL5
10anaphylatoxin459.5CCL5, C5
11choline45 24 1111.4CHKB, APP
12endotoxin459.4CHKB, CCL5
13simvastatin45 51 61 29 24 1114.4CCL5, CHKB, APP
14tacrolimus45 51 1111.4APP, CHKB, CCL5
15aspirin45 51 29 2412.3CCL5, CHKB, APP
16methotrexate51 45 1111.3CCL5, CHKB, APP
17epinephrine45 24 1111.3CHKB, APP, CCL5
18cyclosporin a45 29 6111.3APP, CHKB, CCL5
19creatinine459.3APP, CHKB, CCL5
20heparin45 29 24 1112.3APP, CHKB, CCL5
21h2o2459.3CHKB, CCL5, APP
22cholesterol45 29 24 1112.2APP, CHKB, CCL5
23dexamethasone45 51 29 1112.2CCL5, CHKB, APP
24folate459.2APP, CCL5
25vegf459.2CCL5, CHKB, APP
26glutamate459.1APP, CCL5, CHKB
27cysteine459.0CCL5, APP, CHKB
28alanine458.7DARC, APP, CHKB, CCL5

GO Terms for genes affiliated with Meningoencephalitis

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16Gene Ontology
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Cellular components related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane attack complexGO:0055798.9C5, C9
2extracellular regionGO:0055768.3C5, CCL5, C9, APP

Biological processes related to Meningoencephalitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:0700989.5DARC, CCL5
2complement activation, alternative pathwayGO:0069579.4C9, C5
3regulation of complement activationGO:0304499.4C9, C5
4complement activation, classical pathwayGO:0069589.2C9, C5
5chemotaxisGO:0069359.2CCL5, C5
6cellular calcium ion homeostasisGO:0068749.1CCL5, C5
7inflammatory responseGO:0069548.6DARC, CCL5, C5
8innate immune responseGO:0450878.4C5, C9, APP

Molecular functions related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.2C5, CCL5

Products for genes affiliated with Meningoencephalitis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Meningoencephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet