MCID: MNN009
MIFTS: 47

Meningoencephalitis malady

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

Aliases & Descriptions for Meningoencephalitis:

Name: Meningoencephalitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
ICD10 33 A69.22 G04
MeSH 42 D008590
NCIt 47 C34813
SNOMED-CT 64 7125002
UMLS 69 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to cholera and choroiditis. An important gene associated with Meningoencephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and t cells, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 71 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtᵻs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
id Related Disease Score Top Affiliating Genes
1 cholera 29.3 CD79A IL1B IL6
2 choroiditis 29.3 ALB IL1B IL6
3 tuberculosis 29.3 CD40LG IL1B IL6
4 measles 29.3 GDNF IL1B IL6
5 stiff-person syndrome 29.2 CCL5 CD40LG IL6
6 rheumatoid arthritis 28.7 CCL5 CD40LG CD79A IL1B IL6
7 status epilepticus 28.7 CCL5 IL1B MBP
8 primary amebic meningoencephalitis 12.3
9 lymphocytic choriomeningitis 11.6
10 listeriosis 11.1
11 encephalitis 11.1
12 tick-borne encephalitis 11.1
13 west nile fever 10.7
14 tick infestation 10.7
15 amoebiasis due to free-living amoebae 10.7
16 parenchymatous neurosyphilis 10.7
17 atopic dermatitis 6 10.4 ALB CD79A
18 alcoholic neuropathy 10.4 CD40LG CD79A
19 camptodactyly vertebral fusion 10.4 CD40LG CD79A
20 rabies 10.3 CD40LG CD79A
21 unilateral retinoblastoma 10.3 CD40LG CD79A
22 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
23 delta chain disease 10.3 CD40LG CD79A
24 bile duct adenocarcinoma 10.3 ALB CD40LG
25 discitis 10.3 CD40LG CD79A
26 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
27 trichostrongyloidiasis 10.3 CD40LG CD79A
28 schneiderian carcinoma 10.3 ALB CD79A
29 heart septal defect 10.3 CD40LG CD79A
30 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
31 mild pre-eclampsia 10.3 CD40LG CD79A
32 retinal microaneurysm 10.3 CD40LG CD79A
33 gilles de la tourette syndrome 10.3 ALB B2M
34 malignant renovascular hypertension 10.3 CD79A NGF
35 generalized atherosclerosis 10.3 CD40LG CD79A IL6
36 colloid adenoma 10.3 ALB CD40LG CD79A
37 pediatric meningioma 10.3 CD40LG CD79A
38 striatonigral degeneration 10.3 ALB CD40LG CD79A
39 retinal degeneration 10.3 CD40LG CD79A IL6
40 lateral cystocele 10.3 CD40LG CD79A IL6
41 tonsil cancer 10.3 CD40LG CD79A
42 coronary artery dissection, spontaneous 10.3 ALB CD40LG CD79A
43 bladder sarcoma 10.3 ALB CD79A IL6
44 estrogen excess 10.3 ALB CD40LG
45 inner ear disease 10.3 ALB CD40LG IL6
46 dermatomycosis 10.3 ALB CD40LG CD79A
47 indomethacin antenatal infection 10.3 CD40LG CD79A
48 disease of mental health 10.3 CD40LG CD79A IL6
49 spastic entropion 10.3 ALB CD40LG CD79A
50 autonomic peripheral neuropathy 10.3 ALB CD40LG CD79A

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CD79A CREBBP IL1B IL6 MBP MECP2
2 immune system MP:0005387 10.22 C5 CARD9 CCL5 CD40LG CD79A CREBBP
3 hematopoietic system MP:0005397 10.2 APP B2M CARD9 CCL5 CD40LG CD79A
4 cellular MP:0005384 10.18 MECP2 ALB APP B2M CD40LG CD79A
5 cardiovascular system MP:0005385 10.15 B2M C5 CD40LG CREBBP GDNF IL1B
6 mortality/aging MP:0010768 10.03 ALB APP B2M C5 CD40LG CREBBP
7 integument MP:0010771 9.97 APP B2M CD40LG CREBBP IL1B IL6
8 liver/biliary system MP:0005370 9.8 ALB B2M CD79A CREBBP IL6 MECP2
9 nervous system MP:0003631 9.73 APP B2M C5 CD40LG CD79A CREBBP
10 neoplasm MP:0002006 9.63 ALB B2M CD79A CREBBP IL1B IL6
11 normal MP:0002873 9.23 ALB APP C5 CD79A CREBBP MBP

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 3,Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Antibodies Phase 3,Phase 1,Phase 2
5 gamma-Globulins Phase 3
6 Immunoglobulins Phase 3,Phase 1,Phase 2
7 Immunoglobulins, Intravenous Phase 3
8 Rho(D) Immune Globulin Phase 3
9 Antifungal Agents Phase 3,Phase 2
10 Anti-Infective Agents Phase 3,Phase 2
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
12 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Neurotransmitter Agents Phase 3
17 Steroid Synthesis Inhibitors Phase 3,Phase 2
18 Antidepressive Agents Phase 3
19 Neurotransmitter Uptake Inhibitors Phase 3
20 Psychotropic Drugs Phase 3
21
Serotonin Phase 3 50-67-9 5202
22 Serotonin Agents Phase 3
23 Serotonin Uptake Inhibitors Phase 3
24
Aluminum hydroxide Approved Phase 2 21645-51-2
25
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
26
Tamoxifen Approved Phase 2 10540-29-1 2733526
27
Hydroxychloroquine Approved Phase 2 118-42-3 3652
28 Vaccines Phase 2,Phase 1
29 Adjuvants, Immunologic Phase 2
30 Aluminum sulfate Phase 2
31 Antacids Phase 2
32 Anti-Ulcer Agents Phase 2
33 Gastrointestinal Agents Phase 2
34 Antibodies, Monoclonal Phase 1, Phase 2
35 Anti-Bacterial Agents Phase 2
36 Antiparasitic Agents Phase 2
37 Antiprotozoal Agents Phase 2
38 Antimalarials Phase 2
39 Antineoplastic Agents, Hormonal Phase 2
40 Bone Density Conservation Agents Phase 2
41 Cytochrome P-450 CYP3A Inhibitors Phase 2
42 Estrogen Antagonists Phase 2
43 Estrogen Receptor Modulators Phase 2
44 Estrogens Phase 2
45 Liposomal amphotericin B Phase 2
46 Selective Estrogen Receptor Modulators Phase 2
47 Antirheumatic Agents Phase 2
48
Acetaminophen Approved 103-90-2 1983
49
Ceftriaxone Approved 73384-59-5 5479530 5361919
50
Dopamine Approved 51-61-6, 62-31-7 681

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Recruiting NCT02308982 Phase 3
2 Cryptococcal Antigen Screening Plus Sertraline Not yet recruiting NCT03002012 Phase 3
3 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
4 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
5 Phase Ib Study of SC Milatuzumab in SLE Recruiting NCT01845740 Phase 1, Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2
7 Study of Anti-Malarials in Incomplete Lupus Erythematosus Not yet recruiting NCT03030118 Phase 2
8 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
9 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
10 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1
11 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1
12 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
13 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
14 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
15 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
16 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Recruiting NCT02868593
17 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469
18 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Recruiting NCT02624453
19 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
20 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
21 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

39
Brain, Pituitary, T Cells, Skin, B Cells, Kidney, Testes

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 741)
id Title Authors Year
1
Identification of Naegleria fowleri Proteins Linked to Primary Amebic Meningoencephalitis. ( 28086072 )
2017
2
Necrotizing meningoencephalitis caused by Sarcocystis falcatula in bare-faced ibis (Phimosus infuscatus). ( 27915419 )
2017
3
Biofilm is associated with chronic streptococcal meningoencephalitis in fish. ( 27890651 )
2017
4
RETROSPECTIVE STUDY EVALUATING ASSOCIATIONS BETWEEN MIDLINE BRAIN SHIFT ON MAGNETIC RESONANCE IMAGING AND SURVIVAL IN DOGS DIAGNOSED WITH MENINGOENCEPHALITIS OF UNKNOWN ETIOLOGY. ( 27774741 )
2017
5
Relapsing polychondritis with meningoencephalitis. ( 28207003 )
2017
6
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
7
A newborn with hemorrhagic meningoencephalitis due to Proteus mirabilis. ( 27990007 )
2017
8
Magnetic resonance imaging and magnetic resonance spectroscopy in Salmonella meningoencephalitis. ( 27195046 )
2016
9
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
10
Recovery from a possible cytomegalovirus meningoencephalitis-induced apparent brain stem death in an immunocompetent man: a case report. ( 27566463 )
2016
11
Brucellar Aortitis and Meningoencephalitis in an Adolescent. ( 27832029 )
2016
12
Neuroglucopenia and Metabolic Distress in Two Patients with Viral Meningoencephalitis: A Microdialysis Study. ( 27112148 )
2016
13
Baylisascaris procyonis-Associated Meningoencephalitis in a Previously Healthy Adult, California, USA. ( 27434260 )
2016
14
Severe West Nile virus meningoencephalitis in a pediatric renal transplant recipient: successful recovery and long-term neuropsychological outcome. ( 27470315 )
2016
15
Integrated analysis neurimmiRs of tilapia (Oreochromis niloticus) involved in immune response to Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts. ( 27956091 )
2016
16
Enterovirus 71 Meningoencephalitis With Extensive White Matter Damage. ( 27753776 )
2016
17
Naegleria fowleri Meningoencephalitis Associated with Public Water Supply, Pakistan, 2014. ( 27648572 )
2016
18
Meningoencephalitis, myositis, and rash-neurological presentation of Indian tick typhus. ( 27365979 )
2016
19
Birds of a feather: an uncommon cause of pneumonia and meningoencephalitis. ( 27620382 )
2016
20
Prognostic factors for 1-week survival in dogs diagnosed with meningoencephalitis of unknown aetiology. ( 27387733 )
2016
21
Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5). ( 27477504 )
2016
22
CD4 and CD8 T cells mediate distinct lethal meningoencephalitis in mice challenged with Tacaribe arenavirus. ( 27569560 )
2016
23
Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla. ( 27111012 )
2016
24
A rare cause of cerebral venous thrombosis: cryptococcal meningoencephalitis. ( 27025504 )
2016
25
Blood-CSF-barrier dysfunction is a marker for encephalitic involvement in patients with aseptic meningitis/meningoencephalitis. ( 27736668 )
2016
26
Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli. ( 27030919 )
2016
27
Autoimmune meningoencephalitis in a melanoma patient treated with ipilimumab. ( 27605066 )
2016
28
Primary Amebic Meningoencephalitis as Cause of Headache and Fever. ( 27175836 )
2016
29
Isolation and genotyping of Acanthamoeba spp. from Acanthamoeba meningitis/ meningoencephalitis (AME) patients in India. ( 27507421 )
2016
30
Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report. ( 27043004 )
2016
31
Unusual magnetic resonance imaging presentation of post-BMT cerebral toxoplasmosis masquerading as meningoencephalitis and ventriculitis. ( 27348541 )
2016
32
The Rapid Effectiveness of Minocycline against Scrub Typhus Meningoencephalitis. ( 27041169 )
2016
33
Late Ebola virus relapse causing meningoencephalitis: a case report. ( 27209148 )
2016
34
Delayed Diagnosis of Disseminated Cryptococcosis with Associated Meningoencephalitis in an Immunocompetent Septuagenarian Host. ( 27566500 )
2016
35
Aspergillus meningoencephalitis in a patient with human immunodeficiency virus infection: Normal cerebrospinal fluid does not mean absence of meningitis. ( 27890955 )
2016
36
Clinical presentation, diagnostic findings and long-term survival in large breed dogs with meningoencephalitis of unknown aetiology. ( 27165997 )
2016
37
Corticosteroids for the management of severe intracranial hypertension in meningoencephalitis caused by Cryptococcus gattii: A case report and review. ( 27818191 )
2016
38
Neonatal Meningoencephalitis Caused by Streptococcus gallolyticus. ( 27071020 )
2016
39
Fatal meningoencephalitis secondary to nematode Halicephalobus gingivalis infection in a human. ( 27772835 )
2016
40
Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient without Known Immunosuppression. ( 27994109 )
2016
41
Primary amoebic meningoencephalitis in North Queensland - The diagnostic challenges of Naegleria fowleri. ( 27772819 )
2016
42
Ganciclovir and Foscarnet Therapy of Cytomegalovirus-Associated Meningoencephalitis in a Hemodialysis Patient With Liver Transplantation: Case Report. ( 27320588 )
2016
43
Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5A Years? ( 27614893 )
2016
44
Notes from the Field: Primary Amebic Meningoencephalitis Associated with Exposure to Swimming Pool Water Supplied by an Overland Pipe - Inyo County, California, 2015. ( 27123690 )
2016
45
Cross-reactivity of the 31 kDa antigen of Angiostrongylus cantonensis - Dealing with the immunodiagnosis of meningoencephalitis. ( 27866477 )
2016
46
Platelet Activating Factor (PAF) Receptor Deletion or Antagonism Attenuates Severe HSV-1 Meningoencephalitis. ( 27193134 )
2016
47
Comparison of the clinical presentations of Naegleria fowleri primary amoebic meningoencephalitis with pneumococcal meningitis: a case-control study. ( 26922583 )
2016
48
Acute West Nile virus meningoencephalitis diagnosed via metagenomic deep sequencing of cerebrospinal fluid in a renal transplant patient. ( 27647685 )
2016
49
Primary amebic meningoencephalitis: Summarization on cases with early diagnosis by identification of amebae trophozoite in the cerebrospinal fluid. ( 27195047 )
2016
50
Rapid Fatal Outcome of Cryptococcal Meningoencephalitis in a Non-HIV Immunocompromised Patient with a Low Fluconazole Susceptibility Isolate: A Case Report from Madagascar. ( 28078149 )
2016

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 APP B2M C5 CARD9 CCL5 CD40LG
2
Show member pathways
13.15 CCL5 CD40LG CREBBP IL1B IL6 NGF
3
Show member pathways
12.85 CARD9 CCL5 CREBBP IL1B IL6
4
Show member pathways
12.65 C5 CCL5 CREBBP IL1B IL6
5
Show member pathways
12.59 B2M C5 CD40LG GDNF IL1B IL6
6
Show member pathways
12.56 APP CCL5 CREBBP IL1B IL6
7
Show member pathways
12.51 CD40LG CREBBP IL1B IL6 NGF
8 12.42 APP MBP MECP2 NGF
9
Show member pathways
12.18 ALB CCL5 IL1B IL6
10 12.13 B2M CARD9 CCL5 CD40LG CD79A IL1B
11 12.03 CARD9 CREBBP IL1B IL6
12 11.87 CREBBP IL1B IL6 MECP2 NGF
13 11.81 CCL5 IL1B IL6
14 11.71 CCL5 IL1B IL6
15
Show member pathways
11.68 APP CD40LG NGF
16 11.62 C5 IL1B IL6
17
Show member pathways
11.51 CD40LG IL1B IL6
18 11.43 C5 GDNF IL1B IL6 MBP
19 11.42 CCL5 IL1B IL6 MECP2
20 11.32 CCL5 IL1B IL6
21 11.3 CD40LG IL1B IL6
22 11.04 CCL5 CD40LG IL1B IL6
23 10.77 IL1B IL6
24 10.47 C5 CCL5 IL1B IL6

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB APP B2M C5 CCL5 CD40LG
2 endoplasmic reticulum lumen GO:0005788 9.56 ALB APP B2M IL6
3 external side of plasma membrane GO:0009897 9.46 B2M CD40LG CD79A IL6
4 extracellular space GO:0005615 9.28 ALB APP B2M C5 CCL5 CD40LG

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 ALB CD40LG GDNF IL6 NGF
2 positive regulation of gene expression GO:0010628 9.81 APP IL1B IL6 NGF
3 MAPK cascade GO:0000165 9.8 CCL5 GDNF IL1B MBP
4 cellular protein metabolic process GO:0044267 9.73 ALB APP B2M IL6
5 inflammatory response GO:0006954 9.72 C5 CCL5 CD40LG IL1B IL6
6 defense response to Gram-positive bacterium GO:0050830 9.65 B2M CARD9 IL6
7 adult locomotory behavior GO:0008344 9.54 APP GDNF MECP2
8 neuron projection development GO:0031175 9.46 APP GDNF IL6 MECP2
9 positive regulation of interleukin-6 production GO:0032755 9.43 CARD9 IL1B IL6
10 immune response GO:0006955 9.43 B2M CCL5 CD40LG IL1B IL6 MBP
11 response to peptidoglycan GO:0032494 9.4 CARD9 IL6
12 positive regulation of T cell proliferation GO:0042102 8.92 CCL5 CD40LG IL1B IL6

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL5 CD40LG IL1B IL6
2 receptor binding GO:0005102 9.02 APP C5 GDNF IL6 NGF
3 protein binding GO:0005515 10 ALB APP B2M C5 CARD9 CCL5

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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