MCID: MNN009
MIFTS: 50

Meningoencephalitis malady

Summaries for Meningoencephalitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Meningoencephalitis (/mɛˌnɪŋɡɵ.ɛnˌsɛfəˈlaɪtɨs/; from Greek: meninges- membranes; enkephalos... more...

MalaCards: Meningoencephalitis is related to pneumonia and meningitis. An important gene associated with Meningoencephalitis is C9 (complement component 9), and among its related pathways are Terminal pathway of complement and Prion diseases. The compounds pge2 and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and skin, and related mouse phenotypes are skeleton and immune system.

Disease Ontology:8 A central nervous system disease that involves encephalitis which occurs along with meningitis.

Aliases & Classifications for Meningoencephalitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

meningoencephalitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:10554
NCIt39 C34813
SNOMED-CT56 7125002
MeSH34 D008590

Related Diseases for Meningoencephalitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 255)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.6HSPG2, CCL5, CD79A, CXCL2, C5AR1
2meningitis30.6CD79A
3mumps30.5CD79A
4herpes simplex30.5CCL5, CD79A, DARC
5lupus erythematosus30.3CD40LG, CD79A
6agammaglobulinemia30.3CD40LG, CD79A
7hepatitis30.2GPT, SLC17A5
8scrub typhus30.2SLC17A5, GPT, CD40LG
9systemic lupus erythematosus30.2HSPG2, CCL5, CD40LG, CD79A, C5AR1
10neuritis30.0MBP, CCL5
11influenza30.0CCL5, CD79A
12encephalitis30.0CCL5, MBP, APP, DARC, C5AR1
13dementia29.9APP
14myocarditis29.9CHKB
15optic neuritis29.9MBP
16hypertension29.9CD79A
17thyroiditis29.9CD79A
18neuropathy29.9MBP, CD79A
19multiple sclerosis29.9MBP, CCL5, HSPG2
20vasculitis29.9CD79A, CD40LG
21sarcoidosis29.9TACR1, CCL5
22alzheimer's disease29.9HSPG2, APP, CHKB, TACR1, C5AR1
23leukemia29.9MBP, CD40LG, CD79A, CXCL2, C5AR1
24inflammatory bowel disease29.7CD79A
25otitis media29.7CD79A
26candidiasis29.7CD79A
27peritonitis29.7CXCL2, C5AR1
28kawasaki disease29.7GPT
29rhinitis29.7CD79A, CCL5
30dermatomyositis29.7CHKB, HSPG2
31amyloidosis29.7APP, CD79A
32encephalomyelitis29.7C5AR1, CXCL2, MBP
33rubella29.7CD40LG, CD79A
34purpura29.7CD79A, HSPG2
35guillain-barre syndrome29.7CD40LG, MBP
36viral hepatitis29.7SLC17A5, GPT
37arthritis29.7CCL5, CXCL2, TACR1, C5AR1
38cholera29.7HSPG2, CD79A, C5AR1
39tuberculosis29.7C5AR1, CD79A, MBP
40infectious mononucleosis29.7CD79A, CD40LG
41myopathy29.7APP, CHKB, GPT, SLC17A5
42measles29.7TACR1, CD79A, CD40LG, MBP
43asthma29.7CCL5, MBP, CHKB, CD79A, TACR1, C5AR1
44primary amebic meningoencephalitis10.7
45hydrocephalus10.3
46cerebritis10.3
47parotitis10.2
48herpes zoster10.2
49typhus10.2
50acquired immunodeficiency syndrome10.2

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to meningoencephalitis

Clinical Features for Meningoencephalitis

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Drugs & Therapeutics for Meningoencephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Meningoencephalitis

Drug clinical trials:

Search ClinicalTrials for Meningoencephalitis

Search NIH Clinical Center for Meningoencephalitis

Search CenterWatch for Meningoencephalitis

Genetic Tests for Meningoencephalitis

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Anatomical Context for Meningoencephalitis

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32MalaCards
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MalaCards organs/tissues related to Meningoencephalitis:

32
Brain, Pituitary, Skin, Kidney, T cells, B cells, Thyroid, Testes, Spinal cord, Endothelial

Animal Models for Meningoencephalitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Meningoencephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.6CD40LG, TACR1, C5AR1, C5, CHKB
2MP:00053878.4C5, HSPG2, CCL5, MBP, APP, ATG9A
3MP:00053768.3CHKB, APP, MBP, HSPG2, CD40LG, CD79A

Publications for Meningoencephalitis

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Sources:
50PubMed
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Articles related to Meningoencephalitis:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. (23953389)
2013
2
Granulomatous amoebic meningoencephalitis. (24262461)
2013
3
Malignant catatonia secondary to viral meningoencephalitis in a young man with bipolar disorder. (23857838)
2013
4
Progressive meningoencephalitis due to neurosarcoidosis. (22841014)
2013
5
Balamuthia Mandrillaris Meningoencephalitis associated with Solid Organ Transplantation - Review of Cases. (24421953)
2013
6
Autoimmune-induced focal meningoencephalitis. (21907463)
2013
7
Photo Quiz. Primary amebic meningoencephalitis. (23166205)
2012
8
Primary amoebic meningoencephalitis in an Iranian infant. (22899941)
2012
9
Measurement of antifungal drug levels in cerebrospinal fluid for cryptococcal meningoencephalitis. (22318291)
2012
10
Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis. (22686439)
2012
11
Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency. (20842068)
2011
12
Stiff-person syndrome following tick-borne meningoencephalitis. (22283113)
2011
13
Levofloxacin for the treatment of Mycoplasma pneumoniae-associated meningoencephalitis in childhood. (21377335)
2011
14
Best cases from the AFIP: Balamuthia mandrillaris amebic meningoencephalitis. (21257931)
2011
15
Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis. (22567472)
2011
16
A case of meningoencephalitis caused by Listeria monocytogenes in a healthy child. (21189933)
2010
17
Primary amoebic meningoencephalitis: first reported case from Rohtak, North India. (20191204)
2009
18
A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant. (18463893)
2009
19
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs. (19645838)
2009
20
Septic shock, necrotizing pneumonitis, and meningoencephalitis caused by Mycoplasma pneumoniae in a child: a case report. (19023109)
2009
21
Coxsackie B meningoencephalitis in a patient with acquired immunodeficiency syndrome and a multiple sclerosis-like illness. (19444695)
2009
22
Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. (19014875)
2009
23
White matter damage in neonatal enterovirus meningoencephalitis. (18695167)
2008
24
Liposomal amphotericin B for a case of intractable cryptococcal meningoencephalitis and immune reconstitution syndrome. (18797146)
2008
25
Primary amoebic meningoencephalitis: a new case from Venezuela. (18820207)
2008
26
Loa loa meningoencephalitis in Southwestern Nigeria. (17939321)
2007
27
Relapsing polychondritis presenting as meningoencephalitis with valvular abnormality: a case report. (17404785)
2007
28
BK virus associated meningoencephalitis in an AIDS patient treated with HAART. (17559655)
2007
29
Acute meningoencephalitis caused by adenovirus serotype 26. (16877305)
2006
30
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
31
Communicating hydrocephalus as a complication of eosinophilic meningoencephalitis. (16881436)
2006
32
Elsberg syndrome with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis. (17170511)
2006
33
Syndrome of inappropriate antidiuretic hormone secretion in a patient with cryptococcal meningoencephalitis: a hidden mediastinal small cell carcinoma. (16702802)
2006
34
Tickborne meningoencephalitis, first case after 19 years in northeastern Germany. (15834983)
2005
35
Toxoplasmic meningoencephalitis in an immunocompetent host. (16111730)
2005
36
Cerebral infarction and meningoencephalitis following hot-iron disbudding of goat kids. (16220135)
2005
37
Polyarteritis nodosa with central nervous system involvement mimicking meningoencephalitis. (15115570)
2004
38
Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs. (15521442)
2004
39
Pathologic quiz case. Progressive fatal encephalopathy in an immunosuppressed patient with a history of discoid lupus erythematosus. Subacute granulomatous meningoencephalitis (Acanthamoeba culbertsoni). (15335263)
2004
40
Primary amebic meningoencephalitis--Georgia, 2002. (14534512)
2003
41
Tuberculous meningoencephalitis in Baghdad, 1993-99: a clinical study of 224 cases. (15339121)
2002
42
Enteroviral meningoencephalitis in X-linked agammaglobulinemia: intensive immunoglobulin therapy and sequential viral detection in cerebrospinal fluid by polymerase chain reaction. (11099099)
2000
43
Borna disease in a dog with lethal meningoencephalitis. (9650982)
1998
44
Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. (1315948)
1992
45
Vogt-Koyanagi-Harada disease presenting meningoencephalitis. Report of a case with magnetic resonance imaging. (1373385)
1992
46
Successful treatment of primary amebic meningoencephalitis. (7054710)
1982
47
Primary amebic meningoencephalitis. (7413046)
1980
48
Clinical-pathological conference. Primary amebic meningoencephalitis in a healthy 7-year-old boy. (4604236)
1974
49
Primary amebic meningoencephalitis in California. (5039810)
1972
50
Primary amebic meningoencephalitis. (5410785)
1970

Genetic Variations for Meningoencephalitis

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Expression for genes affiliated with Meningoencephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for genes affiliated with Meningoencephalitis

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Meningoencephalitis

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44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Meningoencephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1pge24410.7CXCL2
2alpha-hydroxybutyrate4410.4GPT, SLC17A5, CHKB
3endotoxin4410.3SLC17A5, CHKB, CXCL2
4lactulose4410.2CD79A, GPT, SLC17A5
5risperidone28 44 49 59 11 2415.2SLC17A5, CHKB, GPT, APP
6valproate4410.1SLC17A5, GPT, APP, CD79A, CD40LG
7tacrolimus44 49 1112.1GPT, CD79A, CHKB, SLC17A5, CCL5
8rantes4410.1CD40LG, DARC, C5AR1, CXCL2
9phenytoin44 49 28 1113.1CD79A, CD40LG, CHKB, SLC17A5
10neopterin4410.0SLC17A5, CD79A, CD40LG, CHKB, GPT
11pneumococcal4410.0SLC17A5, CD79A, CD40LG
12fenofibrate44 49 1112.0SLC17A5, CCL5, CD40LG, GPT
13polyethylene glycol4410.0SLC17A5, CD79A, CD40LG, CHKB, MBP
14methacholine44 1111.0CD79A, MBP, TACR1, CCL5
15simvastatin44 49 59 28 11 2415.0GPT, CHKB, APP, CCL5, HSPG2, SLC17A5
16cocaine44 1111.0SLC17A5, CD40LG, CHKB, MBP, GPT
17aspirin44 49 28 2413.0CCL5, CD40LG, CD79A, CHKB, APP, HSPG2
18thyroxine44 2410.9SLC17A5, GPT, CHKB, CD79A, CD40LG
19ivig449.9GPT, CD79A, CD40LG, MBP
20acetylcholine44 49 28 11 2413.9MBP, HSPG2, CD40LG, APP, TACR1
21choline44 11 2411.9APP, MBP, GPT, HSPG2, TACR1, CHKB
22formaldehyde44 2410.9MBP, APP, CD40LG, TACR1, CD79A
23hyaluronic acid44 2410.9CD79A, CXCL2, SLC17A5, GPT, CD40LG
24dexamethasone44 49 28 1112.8TACR1, CXCL2, CD40LG, APP, CD79A, CCL5
25indomethacin44 59 28 1112.8HSPG2, CCL5, MBP, CD79A, CD40LG, TACR1
26folate449.8CD79A, SLC17A5, CD40LG, APP, CCL5
27methotrexate44 49 1111.8GPT, SLC17A5, CD79A, CHKB, APP, MBP
28prednisolone44 28 1111.8CHKB, MBP, CD79A, GPT, SLC17A5, C5AR1
29ccl444 2810.8CCL5, CXCL2, GPT, SLC17A5
30malondialdehyde449.8GPT, SLC17A5, CXCL2, CHKB
31epinephrine44 11 2411.8MBP, CCL5, CHKB, CD40LG, SLC17A5, CD79A
32heparin44 28 11 2412.8APP, CD40LG, HSPG2, CCL5, CHKB, CD79A
33histamine44 28 2411.7CD79A, HSPG2, CCL5, CD40LG, TACR1, C5AR1
34norepinephrine44 11 2411.7MBP, SLC17A5, APP, CHKB, CD40LG, TACR1
35vitamin b12449.7GPT, SLC17A5, CD40LG, CD79A
36glutamine449.7HSPG2, MBP, SLC17A5, APP, CHKB, GPT
37ethanol44 49 11 2412.7CXCL2, TACR1, CCL5, SLC17A5, GPT, C5AR1
38adenylate449.7HSPG2, GPT, APP, TACR1, CD40LG, CHKB
39aspartate449.7C5AR1, APP, CHKB, TACR1, SLC17A5, CD40LG
40cyclosporin a44 28 5911.6SLC17A5, GPT, CD79A, CD40LG, CHKB, CCL5
41h2o2449.6CHKB, C5AR1, SLC17A5, HSPG2, CXCL2, MBP
42fibrinogen449.6SLC17A5, CXCL2, C5AR1, GPT, CD40LG, CD79A
43n acetylcysteine449.6CD40LG, SLC17A5, GPT, CXCL2, CD79A, CHKB
44lactate449.5MBP, CCL5, SLC17A5, CXCL2, CHKB, CD40LG
45vegf449.5APP, C5AR1, CXCL2, CD79A, CD40LG, CCL5
46creatinine449.4MBP, APP, CHKB, CD40LG, CD79A, C5AR1
47glutamate449.3CCL5, GPT, APP, SLC17A5, CD79A, MBP
48phosphatidylserine44 28 1111.2MBP, CD40LG, C5AR1, CD79A, HSPG2
49lipid449.2C5AR1, SLC17A5, GPT, TACR1, APP, CXCL2
50alanine448.9C5AR1, HSPG2, CCL5, MBP, APP, CHKB

GO Terms for genes affiliated with Meningoencephalitis

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16Gene Ontology
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Cellular components related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane attack complexGO:0055799.9C5, C9
2integral to plasma membraneGO:0058879.4C5AR1, SLC17A5, TACR1, CD40LG, C9, APP

Biological processes related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.2C5, C9
2B cell proliferationGO:0421009.8CD79A, CD40LG
3chemotaxisGO:0069359.6CCL5, CXCL2, C5AR1, C5
4inflammatory responseGO:0069549.2C5, C5AR1, DARC, TACR1, CXCL2, CD40LG

Molecular functions related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.0C5, CXCL2, CCL5

Products for genes affiliated with Meningoencephalitis

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  • Antibodies
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Sources for Meningoencephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet