MCID: MNN009
MIFTS: 46

Meningoencephalitis malady

Neuronal diseases category

Summaries for Meningoencephalitis

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Meningoencephalitis (/m??n????.?n?s?f??la?t?s/; from Greek: meninges- membranes; enkephalos brain; and... more...

MalaCards: Meningoencephalitis is related to encephalitis and myositis. An important gene associated with Meningoencephalitis is C9 (complement component 9), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds ptca and cerivastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and skin, and related mouse phenotype immune system.

Disease Ontology:9 A central nervous system disease that involves encephalitis which occurs along with meningitis.

Aliases & Classifications for Meningoencephalitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

meningoencephalitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:10554
NCIt41 C34813
SNOMED-CT59 7125002
MeSH36 D008590

Related Diseases for Meningoencephalitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to meningoencephalitis

Symptoms for Meningoencephalitis

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Drugs & Therapeutics for Meningoencephalitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Meningoencephalitis

Drug clinical trials:

Search ClinicalTrials for Meningoencephalitis

Search NIH Clinical Center for Meningoencephalitis

Search CenterWatch for Meningoencephalitis

Genetic Tests for Meningoencephalitis

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Anatomical Context for Meningoencephalitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Meningoencephalitis:

34
Brain, Pituitary, Skin, Kidney, T cells, Testes, B cells, Thyroid, Spinal cord, Endothelial

Animal Models for Meningoencephalitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Meningoencephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1C5, CCL5, APP, DARC

Publications for Meningoencephalitis

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Sources:
53PubMed
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Articles related to Meningoencephalitis:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Acute phenytoin intoxication in a 4-year-old mimicking viral meningoencephalitis. (23814089)
2013
2
Establishment of a model of Streptococcus iniae meningoencephalitis in Nile tilapia (Oreochromis niloticus). (23218409)
2013
3
Retrospective study of Mycoplasma gallisepticum meningoencephalitis in six turkey flocks in western France. (22878056)
2013
4
Aseptic meningoencephalitis mimicking transient ischaemic attacks. (23325395)
2013
5
Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. (23599314)
2013
6
Complete genome sequence of Streptococcus agalactiae strain SA20-06, a fish pathogen associated to meningoencephalitis outbreaks. (23991251)
2013
7
Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis. (23025483)
2012
8
Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta). (23114049)
2012
9
Pituitary tumor apoplexy presenting as infective meningoencephalitis. (21630035)
2012
10
Long-term immunosuppressive therapy with cyclosporine plus prednisolone for necrotizing meningoencephalitis in a Pekingese dog. (22214856)
2012
11
HHV6 meningoencephalitis sequelae in previously healthy children. (22802100)
2012
12
A rare case of survival from primary amebic meningoencephalitis. (22557831)
2012
13
Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage. (21975129)
2011
14
Tick-borne meningoencephalitis in a 4.5-month-old infant. (20814849)
2011
15
Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. (22051026)
2011
16
Thrombotic thrombocytopenic purpura mimicking an acute meningoencephalitis. (21485766)
2011
17
Onset of meningoencephalitis: disseminated candidiasis. (22181574)
2011
18
Meningoencephalitis associated with hepatitis A infection: a case report and review of literature. (20555050)
2010
19
Pathology in practice. Necrotizing pyogranulomatous meningoencephalitis with intralesional fungal hyphae, consistent with Cladophialophora bantiana. (20113240)
2010
20
Primary amoebic meningoencephalitis: first reported case from Rohtak, North India. (20191204)
2009
21
The rationale for integrated childhood meningoencephalitis surveillance: a case study from Cambodia. (19551241)
2009
22
Update on emerging infections: News from the Centers for Disease Control and Prevention. Primary amebic meningoencephalitis-Arizona, Florida, and Texas, 2007. (19708086)
2009
23
A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant. (18463893)
2009
24
Cogan's syndrome: a rare cause of meningoencephalitis. (19491118)
2009
25
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs. (19645838)
2009
26
Treatment of meningoencephalitis of unknown origin in a dog. (19448257)
2009
27
Necrotizing meningoencephalitis in five Chihuahua dogs. (18487490)
2008
28
Meningoencephalitis associated with human parvovirus B19. (19076847)
2008
29
Meningoencephalitis due to Toscana virus in a French traveler returning from central Italy. (19006512)
2008
30
sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis. (18813709)
2008
31
Regression of white matter MRI abnormalities in nonvasculitic autoimmune inflammatory meningoencephalitis following intravenous immunoglobulin. (17389804)
2007
32
Anthrax meningoencephalitis successfully treated. (17661992)
2007
33
Non-suppurative meningoencephalitis of unknown origin in cats and dogs: an immunohistochemical study. (17275833)
2007
34
Virological and immunological characteristics of fatal Epstein-Barr virus mononucleosis in a 17-year-old Caucasian male presenting with meningoencephalitis and hemophagocytic syndrome. (17849323)
2007
35
Ventricular pneumocephalus and septic meningoencephalitis secondary to dorsal rhinotomy and nasal polypectomy in a dog. (16842045)
2006
36
Acute meningoencephalitis caused by adenovirus serotype 26. (16877305)
2006
37
Meningoencephalitis associated with Staphylococcus warneri in a dog. (17004952)
2006
38
Tickborne meningoencephalitis, first case after 19 years in northeastern Germany. (15834983)
2005
39
Pyogranulomatous meningoencephalitis in a goat due to Corynebacterium ulcerans. (15786922)
2005
40
Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. (15862291)
2005
41
Pathologic quiz case: headache in an 8-year-old child. Primary amebic meningoencephalitis due to Naegleria fowleri. (14736265)
2004
42
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. (12805119)
2003
43
Primary amebic meningoencephalitis--Georgia, 2002. (14534512)
2003
44
Intrathecal humoral immune response in pediatric patients with meningoencephalitis due to Coxsackie B5]. (10363312)
1999
45
From the Centers for Disease Control. Primary amebic meningoencephalitis--North Carolina, 1991. (1640602)
1992
46
Herpes zoster ophthalmicus with delayed cerebral infarction and meningoencephalitis. (3311326)
1987
47
Coxsackievirus B3 producing fatal meningoencephalitis in a patient with X-linked agammaglobulinemia. (6293302)
1983
48
Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. (1259085)
1976
49
Primary amebic meningoencephalitis. (4620947)
1972
50
Mumps meningoencephalitis with and without parotitis. (18147966)
1949

Variations for Meningoencephalitis

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Expression for genes affiliated with Meningoencephalitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for genes affiliated with Meningoencephalitis

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN, 61Thomson Reuters, 58SinoBiological
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Pathways related to Meningoencephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CCL5, APP
2
Show member pathways
9.5CCL5, APP
3
Show member pathways
9.4CCL5, DARC
4
Show member pathways
9.2C9, C5
5
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.2C5, C9
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.2C5, C9
78.8C9, CCL5, C5
8
Show member pathways
8.7C9, APP, C5
9
Show member pathways
8.1C5, CCL5, APP, DARC
10
Show member pathways
8.1C5, DARC, APP, CCL5

Compounds for genes affiliated with Meningoencephalitis

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Meningoencephalitis according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1ptca469.8CCL5, CHKB
2cerivastatin52 46 30 1212.8CHKB, CCL5
3propranolol46 30 52 25 1213.8CCL5, APP
4risperidone46 52 30 62 25 1214.8APP, CHKB
5azathioprine46 3 52 1212.7CHKB, CCL5
6lead469.7CCL5, CHKB
7lovastatin46 52 62 30 1213.7APP, CHKB
8gf 109203x46 6210.6APP, CCL5
9egcg469.6APP, CCL5
10anaphylatoxin469.5CCL5, C5
11choline46 25 1211.4CHKB, APP
12endotoxin469.4CHKB, CCL5
13simvastatin46 52 62 30 25 1214.4CCL5, CHKB, APP
14tacrolimus46 52 1211.4APP, CHKB, CCL5
15aspirin46 52 30 2512.3CCL5, CHKB, APP
16methotrexate52 46 1211.3CCL5, CHKB, APP
17epinephrine46 25 1211.3CHKB, APP, CCL5
18cyclosporin a46 30 6211.3APP, CHKB, CCL5
19creatinine469.3APP, CHKB, CCL5
20heparin46 30 25 1212.3APP, CHKB, CCL5
21h2o2469.3CHKB, CCL5, APP
22cholesterol46 30 25 1212.2APP, CHKB, CCL5
23dexamethasone46 52 30 1212.2CCL5, CHKB, APP
24folate469.2APP, CCL5
25vegf469.2CCL5, CHKB, APP
26glutamate469.1APP, CCL5, CHKB
27cysteine469.0CCL5, APP, CHKB
28alanine468.7DARC, APP, CHKB, CCL5

GO Terms for genes affiliated with Meningoencephalitis

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17Gene Ontology
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Cellular components related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane attack complexGO:0055798.9C5, C9
2extracellular regionGO:0055768.3C5, CCL5, C9, APP

Biological processes related to Meningoencephalitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:0700989.5DARC, CCL5
2complement activation, alternative pathwayGO:0069579.4C9, C5
3regulation of complement activationGO:0304499.4C9, C5
4complement activation, classical pathwayGO:0069589.2C9, C5
5chemotaxisGO:0069359.2CCL5, C5
6cellular calcium ion homeostasisGO:0068749.1CCL5, C5
7inflammatory responseGO:0069548.6DARC, CCL5, C5
8innate immune responseGO:0450878.4C5, C9, APP

Molecular functions related to Meningoencephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.2C5, CCL5

Products for genes affiliated with Meningoencephalitis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Meningoencephalitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet