MCID: MNN009
MIFTS: 49

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
ICD10 32 A69.22 G04
MeSH 41 D008590
NCIt 46 C34813
SNOMED-CT 64 7125002
UMLS 69 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to parotitis and meningitis. An important gene associated with Meningoencephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and NF-KappaB Family Pathway. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and bone, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 72 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
# Related Disease Score Top Affiliating Genes
1 parotitis 30.3 ALB CD79A
2 meningitis 30.1 ALB CD40LG IL6 TLR9
3 acquired immunodeficiency syndrome 29.8 ALB B2M CD40LG CD79A IL6
4 syphilis 29.8 B2M CD40LG CD79A
5 otitis media 29.8 ALB CD40LG CD79A IL6
6 chlamydia 29.8 CD40LG CD79A IL6
7 peritonitis 29.7 ALB B2M IL6
8 cd40 ligand deficiency 29.7 CD40LG CD79A
9 coccidioidomycosis 29.6 CARD9 CD40LG
10 pneumonia 29.5 CCL5 CD40LG IL6 TLR9
11 exanthem 29.4 CD40LG CD79A TLR9
12 progressive multifocal leukoencephalopathy 29.4 CD40LG MBP MECP2
13 guillain-barre syndrome 29.3 ALB CD40LG CD79A MBP
14 toxoplasmosis 29.2 CD40LG CD79A IL6 TLR9
15 chikungunya 29.2 CCL5 CD40LG IL6
16 common variable immunodeficiency 29.1 CD40LG CD79A IL6 TLR9
17 disease of mental health 29.0 APP BDNF MECP2
18 systemic lupus erythematosus 28.5 ALB CCL5 CD40LG CD79A IL6 TLR9
19 multiple sclerosis 28.0 BDNF CCL5 IL6 MBP TLR9
20 inflammatory bowel disease 27.9 ALB CCL5 CD79A IL6 TAC1 TLR9
21 asthma 27.4 BDNF CCL5 CD40LG CD79A IL6 TAC1
22 primary amebic meningoencephalitis 12.4
23 lymphocytic choriomeningitis 11.7
24 tick-borne encephalitis 11.2
25 trichinosis 11.2
26 parenchymatous neurosyphilis 10.9
27 tick infestation 10.9
28 amoebiasis due to free-living amoebae 10.9
29 selective igg deficiency disease 10.6 CD40LG CD79A
30 c1q nephropathy 10.6 CD40LG CD79A
31 ostertagiasis 10.6 ALB CD79A
32 alpha chain disease 10.6 CD40LG CD79A
33 brill-zinsser disease 10.6 CD40LG CD79A
34 exudative glomerulonephritis 10.6 CD40LG CD79A
35 dermatitis, atopic, 3 10.6 ALB CD79A
36 colorado tick fever 10.6 ALB CD40LG
37 salpingo-oophoritis 10.6 CD40LG CD79A
38 early yaws 10.6 CD40LG CD79A
39 ventilation pneumonitis 10.6 CD40LG CD79A
40 chronic interstitial cystitis 10.6 CD40LG CD79A
41 axillary adenitis 10.6 CD40LG CD79A
42 cryofibrinogenemia 10.6 CD40LG CD79A
43 trichostrongyloidiasis 10.6 CD40LG CD79A
44 subacute bacterial endocarditis 10.6 CD40LG CD79A
45 heterophyiasis 10.6 CD40LG CD79A
46 immunoglobulin g deficiency 10.6 CD40LG CD79A
47 plasmodium malariae malaria 10.6 ALB CD40LG
48 orbital granuloma 10.6 CD40LG CD79A
49 transient hypogammaglobulinemia of infancy 10.6 CD40LG CD79A
50 hyperglobulinemic purpura 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 MECP2 TLR9 MBP CD40LG ALB APP
2 homeostasis/metabolism MP:0005376 10.13 MECP2 TLR9 CD40LG ALB APP CD79A
3 hematopoietic system MP:0005397 10.07 TLR9 MBP CD40LG APP CD79A B2M
4 immune system MP:0005387 10 MECP2 TLR9 MBP CD40LG APP CD79A
5 integument MP:0010771 9.76 MECP2 TAC1 CD40LG APP B2M CREBBP
6 nervous system MP:0003631 9.65 MECP2 MBP CD40LG CD79A APP CHKB
7 normal MP:0002873 9.23 MECP2 TAC1 MBP ALB CD79A APP

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3,Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Antibodies Phase 3,Phase 1,Phase 2
5 Immunoglobulins Phase 3,Phase 1,Phase 2
6 Antidepressive Agents Phase 3
7 Antifungal Agents Phase 3,Phase 2
8 Anti-Infective Agents Phase 3,Phase 2
9 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
11 Hormone Antagonists Phase 3,Phase 2
12 Hormones Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Neurotransmitter Agents Phase 3
15 Neurotransmitter Uptake Inhibitors Phase 3
16 Psychotropic Drugs Phase 3
17
Serotonin Phase 3 50-67-9 5202
18 Serotonin Agents Phase 3
19 Serotonin Uptake Inhibitors Phase 3
20 Steroid Synthesis Inhibitors Phase 3,Phase 2
21 gamma-Globulins Phase 3
22 Immunoglobulins, Intravenous Phase 3
23 Rho(D) Immune Globulin Phase 3
24
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
25
Aluminum sulfate Approved Phase 2 10043-01-3
26
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
27
Tamoxifen Approved Phase 2 10540-29-1 2733526
28 Antibodies, Monoclonal Phase 1, Phase 2
29 Vaccines Phase 2,Phase 1
30 Adjuvants, Immunologic Phase 2
31 Antacids Phase 2
32 Anti-Ulcer Agents Phase 2
33 Gastrointestinal Agents Phase 2
34 Anti-Bacterial Agents Phase 2
35 Antiparasitic Agents Phase 2
36 Antiprotozoal Agents Phase 2
37 Antineoplastic Agents, Hormonal Phase 2
38 Bone Density Conservation Agents Phase 2
39 Cytochrome P-450 CYP3A Inhibitors Phase 2
40 Estrogen Antagonists Phase 2
41 Estrogen Receptor Modulators Phase 2
42 Estrogens Phase 2
43 Liposomal amphotericin B Phase 2
44 Selective Estrogen Receptor Modulators Phase 2
45
Ceftriaxone Approved 73384-59-5 5479530 5361919
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
48
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
49 Acyclovir
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Cryptococcal Antigen Screening Plus Sertraline Recruiting NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
2 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
3 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
4 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
5 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
8 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
9 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
10 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
11 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
12 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
13 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
14 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
15 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Recruiting NCT02868593
16 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
17 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
18 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Recruiting NCT02624453 Fluconazole;Antiretroviral therapy
19 EURopean Study on Encephalitis in Intensive CAre Recruiting NCT03144570
20 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
21 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
22 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
23 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Not yet recruiting NCT03378882

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

38
Brain, Pituitary, Bone, Skin, T Cells, Kidney, B Cells

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 785)
# Title Authors Year
1
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. ( 29366968 )
2018
2
Rheumatoid disease: an unusual cause of relapsing meningoencephalitis. ( 29330273 )
2018
3
Neospora caninum and Ehrlichia canis co-infection in a dog with meningoencephalitis. ( 29406569 )
2018
4
Chronic meningoencephalitis caused by Echo virusA 6 in aA patient with common variable immunodeficiency : Successful treatment with pleconaril. ( 29116409 )
2018
5
Pharmacodynamics of Flubendazole for Cryptococcal Meningoencephalitis: Repurposing and Reformulation of an Anti-Parasitic Agent for a Neglected Fungal Disease. ( 29311092 )
2018
6
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States<sup>1</sup>. ( 29260676 )
2018
7
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
8
Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9A month-old infant: a case report. ( 29390957 )
2018
9
<i>Mycoplasma pneumoniae</i> infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. ( 29326371 )
2018
10
Choroid Plexitis and Ependymitis by Magnetic Resonance Imaging are Biomarkers of Neuronal Damage and Inflammation in HIV-negative Cryptococcal Meningoencephalitis. ( 28835663 )
2017
11
A newborn with hemorrhagic meningoencephalitis due to Proteus mirabilis. ( 27990007 )
2017
12
Naturally Acquired Canine Herpesvirus-Associated Meningoencephalitis. ( 28655291 )
2017
13
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
14
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
15
SARCOCYSTIS NEURONA-ASSOCIATED MENINGOENCEPHALITIS IN A PACIFIC WALRUS ( ODOBENDUS ROSMARUS DIVERGENS). ( 29297810 )
2017
16
A novel cause of chronic viral meningoencephalitis: Cache Valley virus. ( 28628941 )
2017
17
Septicemia and meningoencephalitis caused by Listeria monocytogenes in two neonatal llamas. ( 28677403 )
2017
18
Optic Disc Edema in Glial Fibrillary Acidic Protein Autoantibody-Positive Meningoencephalitis. ( 29210929 )
2017
19
Cryptococcal Meningoencephalitis Complicated by Subdural Empyema in an 8-Year-Old Girl With Neonatal-Onset Multisystem Inflammatory Disease Syndrome: A Rare Sequela. ( 28992083 )
2017
20
Snowshoe Hare Virus Causing Meningoencephalitis in a Young Adult From Northern Manitoba, Canada. ( 28948178 )
2017
21
Pitfalls in the Diagnosis and Management of Invasive Pneumococcal Meningoencephalitis - What We Can Learn From a Case. ( 29104430 )
2017
22
CD4<sup>+</sup>T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during<i>Cryptococcus neoformans</i>Meningoencephalitis. ( 29162707 )
2017
23
Identification of Naegleria fowleri Proteins Linked to Primary Amebic Meningoencephalitis. ( 28086072 )
2017
24
An adult case of group A streptococcus meningitis associated with steroid-responsive meningoencephalitis. ( 28804111 )
2017
25
Case Report: Disseminated Shewanella algae Infection with Meningoencephalitis in a Traveler Secondary to Marine Injury in Madagascar. ( 28722617 )
2017
26
Spontaneous rupture of a secondary pituitary abscess causing acute meningoencephalitis: Case report and literature review. ( 28868189 )
2017
27
Ovarian Teratoma Associated with Coexisting anti-N-Methyl-D-Aspartate Receptor and Glial Fibrillary Acidic Protein Autoimmune Meningoencephalitis in an Adolescent Girl: A Case Report. ( 29294378 )
2017
28
A rare case of meningoencephalitis by Listeria monocytogenes in systemic lupus erythematosus: case report and review. ( 28785856 )
2017
29
Case Report: Zika Virus Meningoencephalitis and Myelitis and Associated Magnetic Resonance Imaging Findings. ( 28829736 )
2017
30
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). ( 29284029 )
2017
31
Predisposing Factors Responsible for the Occurrence of Bacterial Purulent Meningoencephalitis ( 29120154 )
2017
32
Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. ( 28721353 )
2017
33
Pathomorphological peculiarities of tuberculous meningoencephalitis associated with HIV infection. ( 29201438 )
2017
34
InfluenzaA B meningoencephalitis. ( 28690035 )
2017
35
Clinical Profile of Scrub Typhus Meningoencephalitis among South Indian Children. ( 29272545 )
2017
36
Cryptococcal antigen negative meningoencephalitis in HIV/AIDS. ( 28784461 )
2017
37
Meningoencephalitis in a Royal Marine after skinning reindeer in Norway. ( 29151040 )
2017
38
A case report: primary amoebic meningoencephalitis in a young Zambian adult. ( 28764655 )
2017
39
Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4(+) Lymphopenia and Secondary Germline or Acquired Defects. ( 28638843 )
2017
40
Tuberculous meningoencephalitis associated with brain tuberculomas during pregnancy: a case report. ( 28659187 )
2017
41
A rare case of fatal meningoencephalitis with septic thromboembolism due to otitis media: a forensic case and review of literature. ( 28739620 )
2017
42
Subarachnoid small vein occlusion due to inflammatory fibrosis-a possible mechanism for cerebellar infarction in cryptococcal meningoencephalitis: a case report. ( 28793877 )
2017
43
Relapsing polychondritis with meningoencephalitis. ( 28207003 )
2017
44
Necrotizing meningoencephalitis caused by Sarcocystis falcatula in bare-faced ibis (Phimosus infuscatus). ( 27915419 )
2017
45
RETROSPECTIVE STUDY EVALUATING ASSOCIATIONS BETWEEN MIDLINE BRAIN SHIFT ON MAGNETIC RESONANCE IMAGING AND SURVIVAL IN DOGS DIAGNOSED WITH MENINGOENCEPHALITIS OF UNKNOWN ETIOLOGY. ( 27774741 )
2017
46
Primary Amebic Meningoencephalitis in Children: A Report ofA Two Fatal Cases and Review of the Literature. ( 28389055 )
2017
47
Biofilm is associated with chronic streptococcal meningoencephalitis in fish. ( 27890651 )
2017
48
Zika Virus Meningoencephalitis. ( 28778266 )
2017
49
Henry II of France (1519-1559) and his death from meningoencephalitis following a cranial trauma. ( 28712901 )
2017
50
Fatal Cache Valley virus meningoencephalitis associated with rituximab maintenance therapy. ( 29282755 )
2017

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ALB APP B2M BDNF CCL5 CD40LG
2 endoplasmic reticulum lumen GO:0005788 9.46 ALB APP B2M IL6
3 extracellular space GO:0005615 9.28 ALB APP B2M CCL5 CD40LG IL6

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 B2M CCL5 CD40LG IL6 MBP
2 cellular protein metabolic process GO:0044267 9.71 ALB APP B2M IL6
3 positive regulation of JNK cascade GO:0046330 9.65 APP CARD9 TLR9
4 inflammatory response GO:0006954 9.55 CCL5 CD40LG IL6 TAC1 TLR9
5 positive regulation of JAK-STAT cascade GO:0046427 9.54 CCL5 IL6
6 positive regulation of T cell proliferation GO:0042102 9.54 CCL5 CD40LG IL6
7 positive regulation of T cell migration GO:2000406 9.52 APP CCL5
8 response to molecule of bacterial origin GO:0002237 9.51 B2M TLR9
9 positive regulation of acute inflammatory response GO:0002675 9.49 IL6 TAC1
10 response to peptidoglycan GO:0032494 9.43 CARD9 IL6
11 positive regulation of interleukin-6 production GO:0032755 9.43 CARD9 IL6 TLR9
12 positive regulation of receptor binding GO:1900122 9.32 B2M BDNF
13 tumor necrosis factor production GO:0032640 8.96 APP TLR9
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 APP CD40LG IL6 TLR9

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 siRNA binding GO:0035197 8.62 MECP2 TLR9

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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47 NDF-RT
50 NINDS
51 Novoseek
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54 OMIM via Orphanet
58 PubMed
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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