MCID: MNN009
MIFTS: 45

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
ICD10 33 A69.22 G04
MeSH 42 D008590
NCIt 47 C34813
SNOMED-CT 64 7125002
UMLS 69 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to transient hypogammaglobulinemia and viral meningitis. An important gene associated with Meningoencephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are NF-KappaB Family Pathway and Neuroscience. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and bone, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 72 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
id Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia 30.3 CD40LG CD79A
2 viral meningitis 30.2 CD40LG CD79A
3 endotheliitis 29.6 BDNF MBP
4 ulcerative colitis 29.3 BDNF IL6 MBP
5 indian tick typhus 29.3 CCL5 CD40LG
6 lymphoma 29.2 ALB CD40LG CD79A IL6 TLR9
7 systemic lupus erythematosus 28.1 ALB CCL5 CD40LG CD79A IL6 TLR9
8 asthma 26.2 BDNF CCL5 CD40LG CD79A IL6 NGF
9 primary amebic meningoencephalitis 12.3
10 lymphocytic choriomeningitis 11.6
11 encephalitis 11.1
12 tick-borne encephalitis 11.1
13 trichinosis 11.0
14 alcoholic neuropathy 10.9 CD40LG CD79A
15 calloso-genital dysplasia 10.9 CD40LG CD79A
16 atopic dermatitis 5 10.9 ALB CD79A
17 mu chain disease 10.9 CD40LG CD79A
18 middle ear carcinoma 10.9 ALB CD40LG
19 rabies 10.9 CD40LG CD79A
20 ovary transitional cell carcinoma 10.9 ALB CD79A
21 familial retinoblastoma 10.9 CD40LG CD79A
22 anti-basement membrane glomerulonephritis 10.9 CD40LG CD79A
23 fetal erythroblastosis 10.9 CD40LG CD79A
24 spinal canal and spinal cord meningioma 10.9 CD40LG CD79A
25 trichostrongyloidiasis 10.9 CD40LG CD79A
26 leukodystrophy 10.9 CD40LG CD79A
27 retinal microaneurysm 10.9 CD40LG CD79A
28 heart septal defect 10.9 CD40LG CD79A
29 cryptorchidism arachnodactyly mental retardation 10.9 CD40LG CD79A
30 acute kidney tubular necrosis 10.8 CD40LG CD79A
31 secretory meningioma 10.8 CD40LG CD79A
32 hodgkin's lymphoma, nodular sclerosis 10.8 CD40LG CD79A
33 imperforate oropharynx-costo vetebral anomalies 10.8 CD40LG CD79A
34 estrogen excess 10.8 ALB CD40LG
35 malignant otitis externa 10.8 CD40LG CD79A
36 benign epilepsy with centrotemporal spikes 10.8 CD40LG CD79A
37 tongue cancer 10.8 CD40LG CD79A
38 hydrops of gallbladder 10.8 CD40LG CD79A
39 gamma heavy chain disease 10.8 CD40LG CD79A
40 fragile x syndrome type 2 10.8 ALB CD40LG
41 diabetic angiopathy 10.8 CD40LG CD79A
42 rosacea conjunctivitis 10.8 CD40LG CD79A
43 cataract 25 10.8 ALB B2M
44 46 xy gonadal dysgenesis 10.8 B2M CD79A
45 heart fibrosarcoma 10.8 CD40LG CD79A
46 alopecia areata 10.8 CD40LG CD79A
47 kidney carcinoma in situ 10.8 CD40LG CD79A
48 cardiac tuberculosis 10.7 CD40LG CD79A
49 dumping syndrome 10.7 CD40LG CD79A
50 leiomyosarcoma 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 ALB APP B2M BDNF CARD9 CD40LG
2 cellular MP:0005384 10.17 IL6 MBP MECP2 SLC17A5 TLR9 ALB
3 hematopoietic system MP:0005397 10.06 CD40LG CD79A IL6 MBP TLR9 APP
4 immune system MP:0005387 10.02 APP B2M CARD9 CCL5 CD40LG CD79A
5 mortality/aging MP:0010768 9.9 ALB APP B2M BDNF CD40LG IL6
6 integument MP:0010771 9.86 APP B2M BDNF CD40LG IL6 MECP2
7 nervous system MP:0003631 9.65 MBP MECP2 NGF SLC17A5 APP B2M
8 normal MP:0002873 9.23 MBP MECP2 NGF TAC1 ALB APP

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 3,Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Antibodies Phase 3,Phase 1,Phase 2
5 Immunoglobulins Phase 3,Phase 1,Phase 2
6 Antidepressive Agents Phase 3
7 Antifungal Agents Phase 3,Phase 2
8 Anti-Infective Agents Phase 3,Phase 2
9 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
11 Hormone Antagonists Phase 3,Phase 2
12 Hormones Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Neurotransmitter Agents Phase 3
15 Neurotransmitter Uptake Inhibitors Phase 3
16 Psychotropic Drugs Phase 3
17
Serotonin Phase 3 50-67-9 5202
18 Serotonin Agents Phase 3
19 Serotonin Uptake Inhibitors Phase 3
20 Steroid Synthesis Inhibitors Phase 3,Phase 2
21 gamma-Globulins Phase 3
22 Immunoglobulins, Intravenous Phase 3
23 Rho(D) Immune Globulin Phase 3
24
Aluminum hydroxide Approved Phase 2 21645-51-2
25
Aluminum sulfate Approved Phase 2 10043-01-3
26
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
27
Tamoxifen Approved Phase 2 10540-29-1 2733526
28
Hydroxychloroquine Approved Phase 2 118-42-3 3652
29 Antibodies, Monoclonal Phase 1, Phase 2
30 Vaccines Phase 2,Phase 1
31 Adjuvants, Immunologic Phase 2
32 Antacids Phase 2
33 Anti-Ulcer Agents Phase 2
34 Gastrointestinal Agents Phase 2
35 Anti-Bacterial Agents Phase 2
36 Antiparasitic Agents Phase 2
37 Antiprotozoal Agents Phase 2
38 Antimalarials Phase 2
39 Antineoplastic Agents, Hormonal Phase 2
40 Bone Density Conservation Agents Phase 2
41 Cytochrome P-450 CYP3A Inhibitors Phase 2
42 Estrogen Antagonists Phase 2
43 Estrogen Receptor Modulators Phase 2
44 Estrogens Phase 2
45 Liposomal amphotericin B Phase 2
46 Selective Estrogen Receptor Modulators Phase 2
47 Antirheumatic Agents Phase 2
48
Ceftriaxone Approved 73384-59-5 5479530 5361919
49
Dopamine Approved 51-61-6, 62-31-7 681
50
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Cryptococcal Antigen Screening Plus Sertraline Recruiting NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
2 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
3 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
4 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
5 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 Study of Anti-Malarials in Incomplete Lupus Erythematosus Not yet recruiting NCT03030118 Phase 2 Hydroxychloroquine;Placebo Oral Capsule
8 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
9 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
10 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
11 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
12 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
13 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
14 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
15 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
16 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Recruiting NCT02868593
17 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
18 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
19 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Recruiting NCT02624453 Fluconazole;Antiretroviral therapy
20 EURopean Study on Encephalitis in Intensive CAre Recruiting NCT03144570
21 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
22 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
23 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

39
Brain, Pituitary, Bone, Skin, T Cells, Kidney, B Cells

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 764)
id Title Authors Year
1
Tuberculous meningoencephalitis associated with brain tuberculomas during pregnancy: a case report. ( 28659187 )
2017
2
Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4(+) Lymphopenia and Secondary Germline or Acquired Defects. ( 28638843 )
2017
3
Snowshoe Hare Virus Causing Meningoencephalitis in a Young Adult From Northern Manitoba, Canada. ( 28948178 )
2017
4
A novel cause of chronic viral meningoencephalitis: Cache Valley virus. ( 28628941 )
2017
5
Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. ( 28721353 )
2017
6
A case report: primary amoebic meningoencephalitis in a young Zambian adult. ( 28764655 )
2017
7
Zika Virus Meningoencephalitis. ( 28778266 )
2017
8
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
9
Primary Amebic Meningoencephalitis in Children: A Report ofA Two Fatal Cases and Review of the Literature. ( 28389055 )
2017
10
A newborn with hemorrhagic meningoencephalitis due to Proteus mirabilis. ( 27990007 )
2017
11
Naturally Acquired Canine Herpesvirus-Associated Meningoencephalitis. ( 28655291 )
2017
12
Septicemia and meningoencephalitis caused by Listeria monocytogenes in two neonatal llamas. ( 28677403 )
2017
13
Subarachnoid small vein occlusion due to inflammatory fibrosis-a possible mechanism for cerebellar infarction in cryptococcal meningoencephalitis: a case report. ( 28793877 )
2017
14
RETROSPECTIVE STUDY EVALUATING ASSOCIATIONS BETWEEN MIDLINE BRAIN SHIFT ON MAGNETIC RESONANCE IMAGING AND SURVIVAL IN DOGS DIAGNOSED WITH MENINGOENCEPHALITIS OF UNKNOWN ETIOLOGY. ( 27774741 )
2017
15
Case Report: Disseminated Shewanella algae Infection with Meningoencephalitis in a Traveler Secondary to Marine Injury in Madagascar. ( 28722617 )
2017
16
Choroid Plexitis and Ependymitis by Magnetic Resonance Imaging are Biomarkers of Neuronal Damage and Inflammation in HIV-negative Cryptococcal Meningoencephalitis. ( 28835663 )
2017
17
An adult case of group A streptococcus meningitis associated with steroid-responsive meningoencephalitis. ( 28804111 )
2017
18
Biofilm is associated with chronic streptococcal meningoencephalitis in fish. ( 27890651 )
2017
19
Case Report: Zika Virus Meningoencephalitis and Myelitis and Associated Magnetic Resonance Imaging Findings. ( 28829736 )
2017
20
Spontaneous rupture of a secondary pituitary abscess causing acute meningoencephalitis: Case report and literature review. ( 28868189 )
2017
21
A rare case of meningoencephalitis by Listeria monocytogenes in systemic lupus erythematosus: case report and review. ( 28785856 )
2017
22
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
23
Necrotizing meningoencephalitis caused by Sarcocystis falcatula in bare-faced ibis (Phimosus infuscatus). ( 27915419 )
2017
24
A rare case of fatal meningoencephalitis with septic thromboembolism due to otitis media: a forensic case and review of literature. ( 28739620 )
2017
25
Relapsing polychondritis with meningoencephalitis. ( 28207003 )
2017
26
Cryptococcal antigen negative meningoencephalitis in HIV/AIDS. ( 28784461 )
2017
27
InfluenzaA B meningoencephalitis. ( 28690035 )
2017
28
Henry II of France (1519-1559) and his death from meningoencephalitis following a cranial trauma. ( 28712901 )
2017
29
Identification of Naegleria fowleri Proteins Linked to Primary Amebic Meningoencephalitis. ( 28086072 )
2017
30
Primary amoebic meningoencephalitis in North Queensland - The diagnostic challenges of Naegleria fowleri. ( 27772819 )
2016
31
Enterovirus 71 Meningoencephalitis With Extensive White Matter Damage. ( 27753776 )
2016
32
The Rapid Effectiveness of Minocycline against Scrub Typhus Meningoencephalitis. ( 27041169 )
2016
33
Naegleria fowleri That Induces Primary Amoebic Meningoencephalitis: Rapid Diagnosis and Rare Case of Survival in a 12-Year-Old Caucasian Girl. ( 26984830 )
2016
34
Recovery from a possible cytomegalovirus meningoencephalitis-induced apparent brain stem death in an immunocompetent man: a case report. ( 27566463 )
2016
35
Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient without Known Immunosuppression. ( 27994109 )
2016
36
Isolation and genotyping of Acanthamoeba spp. from Acanthamoeba meningitis/ meningoencephalitis (AME) patients in India. ( 27507421 )
2016
37
Baylisascaris procyonis-Associated Meningoencephalitis in a Previously Healthy Adult, California, USA. ( 27434260 )
2016
38
Naegleria fowleri Meningoencephalitis Associated with Public Water Supply, Pakistan, 2014. ( 27648572 )
2016
39
WITHDRAWN: Clinical Signs, Neuroanatomical Distribution and Histopathological Characterisation of Meningoencephalitis in Wild Red Foxes (Vulpes vulpes) Associated with a Novel fox Circovirus. ( 27392422 )
2016
40
Late Ebola virus relapse causing meningoencephalitis: a case report. ( 27209148 )
2016
41
A rare cause of cerebral venous thrombosis: cryptococcal meningoencephalitis. ( 27025504 )
2016
42
Notes from the Field: Primary Amebic Meningoencephalitis Associated with Exposure to Swimming Pool Water Supplied by an Overland Pipe - Inyo County, California, 2015. ( 27123690 )
2016
43
Photo Quiz: An 8-Year-Old Boy with Meningoencephalitis. ( 27217384 )
2016
44
Ganciclovir and Foscarnet Therapy of Cytomegalovirus-Associated Meningoencephalitis in a Hemodialysis Patient With Liver Transplantation: Case Report. ( 27320588 )
2016
45
CD4 and CD8 T cells mediate distinct lethal meningoencephalitis in mice challenged with Tacaribe arenavirus. ( 27569560 )
2016
46
Meningoencephalitis due to the amoeboflagellate Naegleria fowleri in ruminants in Algeria. ( 26979770 )
2016
47
Rapid Fatal Outcome of Cryptococcal Meningoencephalitis in a Non-HIV Immunocompromised Patient with a Low Fluconazole Susceptibility Isolate: A Case Report from Madagascar. ( 28078149 )
2016
48
Clinical presentation, diagnostic findings and long-term survival in large breed dogs with meningoencephalitis of unknown aetiology. ( 27165997 )
2016
49
Neonatal Meningoencephalitis Caused by Streptococcus gallolyticus. ( 27071020 )
2016
50
Comparison of the clinical presentations of Naegleria fowleri primary amoebic meningoencephalitis with pneumococcal meningitis: a case-control study. ( 26922583 )
2016

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.72 APP BDNF NGF SLC17A5 TLR9
2 extracellular space GO:0005615 9.61 ALB APP B2M CCL5 CD40LG IL6
3 endoplasmic reticulum lumen GO:0005788 9.56 ALB APP B2M IL6
4 external side of plasma membrane GO:0009897 9.46 B2M CD40LG CD79A IL6
5 extracellular region GO:0005576 9.32 ALB APP B2M BDNF CCL5 CD40LG

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 B2M CCL5 CD40LG IL6 MBP
2 cell-cell signaling GO:0007267 9.81 BDNF CCL5 NGF TAC1
3 neuron projection development GO:0031175 9.72 APP IL6 MECP2
4 cellular protein metabolic process GO:0044267 9.71 ALB APP B2M IL6
5 positive regulation of chemokine production GO:0032722 9.54 IL6 TLR9
6 positive regulation of T cell proliferation GO:0042102 9.5 CCL5 CD40LG IL6
7 response to molecule of bacterial origin GO:0002237 9.49 B2M TLR9
8 positive regulation of acute inflammatory response GO:0002675 9.48 IL6 TAC1
9 positive regulation of JNK cascade GO:0046330 9.46 CARD9 TLR9
10 response to peptidoglycan GO:0032494 9.37 CARD9 IL6
11 inflammatory response GO:0006954 9.35 CCL5 CD40LG IL6 TAC1 TLR9
12 positive regulation of interleukin-6 production GO:0032755 9.33 CARD9 IL6 TLR9
13 positive regulation of receptor binding GO:1900122 9.26 B2M BDNF
14 positive regulation of T cell migration GO:2000406 9.22 CCL5
15 tumor necrosis factor production GO:0032640 8.32 TLR9

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 siRNA binding GO:0035197 8.62 MECP2 TLR9

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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