MCID: MNT002
MIFTS: 53

Mental Depression malady

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Mental Depression

Aliases & Descriptions for Mental Depression:

Name: Mental Depression 12 14 69
Depressive Disorder 69
Depression 42

Classifications:



External Ids:

Disease Ontology 12 DOID:1596
ICD10 33 F32.9 F33.9
MeSH 42 D003863
NCIt 47 C2982
UMLS 69 C0011570

Summaries for Mental Depression

MalaCards based summary : Mental Depression, also known as depressive disorder, is related to perry syndrome and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Mental Depression is IER3IP1 (Immediate Early Response 3 Interacting Protein 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Citalopram and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 perry syndrome 11.7
2 endogenous depression 10.7
3 major depressive disorder and accelerated response to antidepressant drug treatment 10.7
4 adult brainstem astrocytoma 10.3 HTR1A MAOA SLC6A4
5 pyromania 10.3 HTR2A MAOA SLC6A4
6 anodontia 10.3 HTR1A HTR2C SLC6A4
7 nephronophthisis 13 10.3 COMT HTR2A SLC6A4
8 apperceptive agnosia 10.2 COMT HTR1A SLC6A4
9 allergic hypersensitivity disease 10.2 HTR1A HTR2A HTR7
10 vascular cancer 10.2 HTR1A HTR2A HTR7
11 luxation of globe 10.2 HTR1A HTR7 SLC6A4
12 strongyloidiasis 10.2 COMT MAOA SLC6A4
13 kidney pelvis papillary carcinoma 10.2 HTR1A MAOA SLC6A2 SLC6A4
14 polyneuropathy 10.2 HTR1A HTR2A
15 waardenburg's syndrome 10.2 HTR1A HTR2A HTR2C SLC6A4
16 siberian tick typhus 10.2 BDNF HTR1A HTR7
17 mucinous adenocarcinoma 10.2 BDNF MAOA SLC6A4
18 autoimmune disease of endocrine system 10.2 CRH HTR7 POMC
19 abnormal pupillary function 10.2 HTR1A HTR7
20 chagas disease 10.2 BDNF COMT HTR2A SLC6A4
21 hypereosinophilic syndrome 10.2 BDNF MAOA POMC SLC6A4
22 hypoglycemia 10.2 BDNF CRH POMC SLC6A4
23 chronic cervicitis 10.2 CRH MAOA WASF1
24 nonparalytic poliomyelitis 10.2 CRH NR3C1 POMC
25 antisocial personality disorder 10.2 HTR1A HTR2A
26 deafness, autosomal recessive 20 10.2 CRH HTR7 SLC6A4 TPH1
27 tinea pedis 10.2 GATA3 HTR1A HTR7 MAOA SLC6A4
28 neurogenic bladder 10.2 GATA3 HTR2A HTR7 MAOA SLC6A4
29 epithelioid type angiomyolipoma 10.2 BDNF HTR2A IER3IP1 SLC6A2 SLC6A4
30 tuberculous peritonitis 10.2 CRH HTR7 SLC6A4 TPH1
31 merkel cell carcinoma 10.1 CRH NR3C1 POMC
32 conjunctival pigmentation 10.1 CRH GATA3 HTR7 MAOA SLC6A4
33 esophagus squamous cell papilloma 10.1 CRH NR3C1 POMC
34 dry eye syndrome 10.1 HTR1A HTR2A HTR2C HTR7 SLC6A4
35 cytomegalic congenital adrenal hypoplasia 10.1 BDNF COMT HTR2A MAOA SLC6A4
36 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.1 CRH NR3C1 POMC
37 astroblastoma 10.1 CRH OXT POMC
38 colorectal adenocarcinoma 10.1 COMT MAOA SLC6A2 SLC6A4 TPH2
39 aryepiglottic fold cancer 10.1 HTR1A HTR2A
40 sexual disorder 10.1 BDNF OXT SLC6A4
41 simultanagnosia 10.1 HTR7 IER3IP1 OXT POMC
42 cervical carcinosarcoma 10.1 HTR7 IER3IP1 OXT POMC
43 myopathy, distal, with early respiratory failure, autosomal dominant 10.1 COMT HTR7 POMC TPH1
44 anisometropia 10.1 CRH NR3C1 POMC
45 hepatitis b reinfection following liver transplantation 10.1 HTR1A HTR2A MAOA OXT SLC6A4
46 cholesteatoma 10.1 BDNF COMT HTR2C POMC SLC6A4
47 intrahepatic gall duct cancer 10.1 BDNF COMT HTR2A MAOA SLC6A4 TPH2
48 primary angle-closure glaucoma 10.1 BDNF COMT HTR1A HTR2A HTR2C SLC6A4
49 carotid stenosis 10.0 COMT MAOA POMC SLC6A4 TPH1
50 microcephaly 13, primary, autosomal recessive 10.0 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4

Graphical network of the top 20 diseases related to Mental Depression:



Diseases related to Mental Depression

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:


affective symptoms, behavioral symptoms, schizophrenic language, depressive symptoms, dejection emotional, depressed reaction, depression aggravated, depressed - symptom

MGI Mouse Phenotypes related to Mental Depression:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 HTR1A HTR2A HTR2C HTR7 MAOA NR3C1
2 homeostasis/metabolism MP:0005376 10.33 TPH1 TPH2 BDNF COMT CRH DPP4
3 growth/size/body region MP:0005378 10.25 SLC6A4 TPH1 TPH2 WASF1 BDNF CRH
4 cardiovascular system MP:0005385 10.22 COMT GATA3 HTR1A MAOA NR3C1 OXT
5 endocrine/exocrine gland MP:0005379 10.16 BDNF COMT CRH DPP4 GATA3 HTR2A
6 integument MP:0010771 10.15 BDNF CRH GATA3 HTR2C HTR7 NR3C1
7 mortality/aging MP:0010768 10.13 BDNF FKBP5 GATA3 HTR1A HTR2C HTR7
8 adipose tissue MP:0005375 10.11 CRH GATA3 HTR2C NR3C1 OXT POMC
9 nervous system MP:0003631 10.03 BDNF COMT CRH GATA3 HTR1A HTR2C
10 muscle MP:0005369 9.8 GATA3 HTR2A HTR2C NR3C1 SLC6A4 TPH1
11 no phenotypic analysis MP:0003012 9.5 BDNF CRH GATA3 HTR1A NR3C1 POMC
12 renal/urinary system MP:0005367 9.17 CRH FKBP5 GATA3 NR3C1 OXT POMC

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 817)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59729-33-8 2771
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
4
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34841-39-9, 34911-55-2 444
5
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79617-96-2 68617
6
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
7
Fluoxetine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54910-89-3 3386
8
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
9
Tranylcypromine Approved Phase 4,Phase 1,Phase 2,Early Phase 1 155-09-9 441233
10
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
11
Mianserin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 24219-97-4 4184
12
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85650-52-8, 61337-67-5 4205
13
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-23-7 5754 657311
14
Reboxetine Approved, Investigational Phase 4,Phase 2 98769-81-4, 71620-89-8 123628 65856
15
Fluvoxamine Approved, Investigational Phase 4,Phase 1 54739-18-3 3404 5324346
16
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
17
Trazodone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 19794-93-5 5533
18
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
19
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 132539-06-1 4585
20
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
21
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757 53477783
22
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 1 57-63-6 5991
23
Norethindrone Approved Phase 4 68-22-4 6230
24
Eszopiclone Approved Phase 4,Phase 3,Phase 2 138729-47-2 969472
25
Buspirone Approved, Investigational Phase 4,Phase 2 36505-84-7 2477
26
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
27
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1 50-48-6 2160
28
Nortriptyline Approved Phase 4,Phase 2,Phase 1 72-69-5 4543
29
Perphenazine Approved Phase 4,Phase 3,Phase 2,Phase 1 58-39-9 4748
30
Trimipramine Approved Phase 4 739-71-9 5584 4055
31
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
32
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
33
Lactulose Approved Phase 4 4618-18-2 11333
34
Tramadol Approved, Investigational Phase 4,Phase 2 27203-92-5 33741
35
Methyltestosterone Approved Phase 4,Phase 3,Phase 2 58-18-4 6010
36
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2 58-22-0 6013
37
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 2078-54-8 4943
38
Succinylcholine Approved Phase 4 306-40-1 5314
39
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Early Phase 1 616-91-1 12035
40
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
41
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
42
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
43
Rilpivirine Approved Phase 4 500287-72-9
44
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
45
Imipramine Approved Phase 4,Phase 2,Phase 1 50-49-7 3696
46
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
47
Clomipramine Approved, Vet_approved Phase 4,Phase 1 303-49-1 2801
48
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 106266-06-2 5073
49
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 99-66-1 3121
50
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 19982-08-2 4054

Interventional clinical trials:

(show top 50) (show all 5316)
id Name Status NCT ID Phase
1 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care Unknown status NCT00939250 Phase 4
2 The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients Unknown status NCT01278498 Phase 4
3 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4
4 Inflammatory Markers and Cognitive Function in Major Depression Unknown status NCT01391221 Phase 4
5 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4
6 Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients Unknown status NCT02213016 Phase 4
7 Depression Care Management for Depressed Elders in China Primary Care Unknown status NCT01287494 Phase 4
8 Desvenlafaxine vs. Placebo Treatment of Chronic Depression Unknown status NCT01537068 Phase 4
9 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4
10 Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression Unknown status NCT01390662 Phase 4
11 Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Unknown status NCT00442429 Phase 4
12 DECARD: Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4
13 Efficacy Study of Escitalopram for Depression in Patients With Diabetes Unknown status NCT00650897 Phase 4
14 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4
15 Lithium and Standard Therapy in Resistant Depression Unknown status NCT00927550 Phase 4
16 Duloxetine for Major Depression in Peri-/Postmenopausal Women Unknown status NCT00889369 Phase 4
17 Medications for the Treatment of Dysthymic Disorder and Double Depression Unknown status NCT00234312 Phase 4
18 Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4
19 Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder Unknown status NCT01699490 Phase 4
20 Diabetes and Depression in Hispanics and African Americans: Treatment of Depression With Sertraline and Its Effect on A1c and Quality of Life Unknown status NCT00624013 Phase 4
21 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4
22 Treatment of Mild and Subthreshold Depressive Disorders Unknown status NCT00226642 Phase 4
23 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy Unknown status NCT00150839 Phase 4
24 Estrogen and Perimenopausal Depression Unknown status NCT00229450 Phase 4
25 Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression Unknown status NCT00106197 Phase 4
26 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4
27 Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4
28 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
29 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4
30 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4
31 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4
32 Efficacy Study of Botox for Depression Unknown status NCT01556971 Phase 4
33 Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified(OL Study) Unknown status NCT02287259 Phase 4
34 Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4
35 Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales Unknown status NCT02210702 Phase 4
36 Effect of Antidepressants on White Matter Structure Unknown status NCT01492621 Phase 4
37 Benefits of Switching Antidepressants Following Early Nonresponse Unknown status NCT00519012 Phase 4
38 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4
39 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4
40 Major Depressive Disorder - Understanding The Link Between The Brain And The Heart Unknown status NCT01568307 Phase 4
41 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4
42 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4
43 Improving Sleep and Psychological Functioning in People With Depression and Insomnia Unknown status NCT00247624 Phase 4
44 Algorithm Guided Treatment Strategies for Bipolar Depression Unknown status NCT01938859 Phase 4
45 Clinical Pharmacogenomics of Antidepressant Response Unknown status NCT00269334 Phase 4
46 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4
47 Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder Unknown status NCT00209807 Phase 4
48 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4
49 Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Unknown status NCT02237937 Phase 4
50 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: depression

Genetic Tests for Mental Depression

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

39
Heart, Liver, Brain

Publications for Mental Depression

Articles related to Mental Depression:

(show top 50) (show all 55)
id Title Authors Year
1
Correlates of Mental Depression Among Female Sex Workers in Southern India. ( 26307144 )
2015
2
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. ( 21384741 )
2010
3
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. ( 19452408 )
2009
4
A controlled study on treatment of mental depression by acupuncture plus TCM medication. ( 17955648 )
2007
5
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. ( 16447661 )
2005
6
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. ( 15119163 )
2004
7
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. ( 15510791 )
2004
8
DPP IV and mental depression in Crohn's disease. ( 12675254 )
2003
9
Neopterin production, tryptophan degradation, and mental depression--what is the link? ( 12401473 )
2002
10
Carbohydrate malabsorption syndromes and early signs of mental depression in females. ( 10961700 )
2000
11
Fructose malabsorption is associated with early signs of mental depression. ( 9620891 )
1998
12
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. ( 9824144 )
1998
13
A heuristic model of mental depression derived from basic and applied research on thyrotropin-releasing hormone. ( 9827666 )
1998
14
Mental depression and death in elderly persons. ( 9465545 )
1997
15
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. ( 8801470 )
1996
16
Clinical observation on needling extrachannel points in treating mental depression. ( 8196410 )
1994
17
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. ( 1999695 )
1991
18
Nurses and shiftwork: effects on physical health and mental depression. ( 2394892 )
1990
19
Mental depression, acute infection and coma in a patient treated with interferon-alpha. ( 2501183 )
1989
20
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. ( 2594736 )
1989
21
Mental depression is associated with malnutrition in patients with head and neck cancer. ( 3190874 )
1988
22
Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression. ( 3351130 )
1988
23
Mental depression in untreated Parkinson's disease of recent onset. ( 3825724 )
1987
24
Seasonal variation in mental depression and its correlation with occupation. ( 3726602 )
1986
25
Mental depression and kundalini yoga. ( 22557558 )
1986
26
Variations in serum vanadium levels during the treatment of mental depression. ( 3756279 )
1986
27
Platelet serotonin in essential hypertension and in mental depression. ( 2412030 )
1985
28
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. ( 7266825 )
1981
29
Mental depression secondary to fluorouracil therapy for actinic keratoses. ( 7425651 )
1980
30
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. ( 43704 )
1979
31
Solvent exposure and mental depression. ( 509886 )
1979
32
Biochemistry of mental depression. ( 23214 )
1977
33
Pathways to the cure of mental depression. ( 243281 )
1977
34
Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). ( 320830 )
1977
35
Antinuclear factor-positive mental depression: a single disease entity? ( 1083254 )
1976
36
Hereditary mental depression and Parkinsonism with taurine deficiency. ( 1122173 )
1975
37
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4116150 )
1972
38
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4118700 )
1972
39
Chemotherapy of mental depression. ( 4913951 )
1970
40
Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics. ( 5457617 )
1970
41
Parkinsonism, L-dopa and mental depression. ( 5421784 )
1970
42
Vitamin D intoxication, with hypernatraemia, potassium and water depletion, and mental depression. ( 5723727 )
1968
43
Psychopharmacological aspects of mental depression. ( 5328330 )
1966
44
Desipramine and nortriptyline in mental depression. ( 5325569 )
1966
45
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. ( 5962034 )
1966
46
A CLINICAL EVALUATION OF PARGYLINE HYDROCHLORIDE (EUTONYL) IN THE MANAGEMENT OF MENTAL DEPRESSION. ( 14309088 )
1965
47
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. ( 13983943 )
1963
48
Treatment of recurrent mental depression with imipramine. ( 13862250 )
1961
49
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. ( 13616942 )
1958
50
Mental depression associated with hyperadrenocorticism. ( 13533641 )
1958

Variations for Mental Depression

Expression for Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 CRH HTR1A HTR2A HTR2C HTR7 NR3C1
2 12.39 COMT HTR1A POMC TPH1 TPH2
4
Show member pathways
11.82 HTR1A HTR2A HTR2C HTR7
5 11.82 BDNF GATA3 HTR1A HTR2A MAOA NR3C1
6 11.81 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
7 11.79 GATA3 MAOA POMC
8 11.54 FKBP5 GATA3 NR3C1 POMC
9
Show member pathways
11.35 COMT SLC6A2 SLC6A4
10
Show member pathways
11.19 MAOA SLC6A2 SLC6A4 TPH2
11
Show member pathways
11.04 COMT MAOA SLC6A4
12
Show member pathways
10.92 COMT MAOA TPH1
13 10.85 HTR7 NR3C1
14 10.68 COMT MAOA
15
Show member pathways
10.67 COMT MAOA
16 10.67 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
17 10.36 CRH POMC

GO Terms for Mental Depression

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.83 COMT CRH OXT
2 chemical synaptic transmission GO:0007268 9.8 CRH HTR2A HTR2C HTR7 SLC6A2
3 response to estrogen GO:0043627 9.79 CRH GATA3 TPH2
4 memory GO:0007613 9.79 HTR2A OXT SLC6A4
5 positive regulation of fat cell differentiation GO:0045600 9.73 HTR2A HTR2C TPH1
6 circadian rhythm GO:0007623 9.67 HTR7 SLC6A4 TPH1 TPH2
7 locomotory exploration behavior GO:0035641 9.65 CRH DPP4
8 sleep GO:0030431 9.65 HTR2A OXT
9 behavioral fear response GO:0001662 9.65 DPP4 HTR1A HTR2C
10 neurotransmitter catabolic process GO:0042135 9.64 COMT MAOA
11 catecholamine metabolic process GO:0006584 9.64 COMT MAOA
12 regulation of appetite GO:0032098 9.63 HTR2C POMC
13 regulation of behavior GO:0050795 9.63 HTR1A HTR2A
14 monoamine transport GO:0015844 9.62 SLC6A2 SLC6A4
15 dopamine catabolic process GO:0042420 9.61 COMT MAOA
16 aromatic amino acid family metabolic process GO:0009072 9.6 TPH1 TPH2
17 sperm ejaculation GO:0042713 9.58 OXT SLC6A4
18 regulation of hormone secretion GO:0046883 9.58 HTR1A HTR2A
19 dopamine uptake involved in synaptic transmission GO:0051583 9.57 SLC6A2 SLC6A4
20 indolalkylamine biosynthetic process GO:0046219 9.55 TPH1 TPH2
21 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.54 HTR1A HTR7
22 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.52 HTR2A HTR2C
23 response to ether GO:0045472 9.51 CRH OXT
24 response to pain GO:0048265 9.5 COMT CRH SLC6A2
25 serotonin biosynthetic process GO:0042427 9.49 TPH1 TPH2
26 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.46 HTR2A HTR2C
27 regulation of serotonin secretion GO:0014062 9.43 CRH HTR1A
28 vasoconstriction GO:0042310 9.43 HTR1A HTR7 SLC6A4
29 behavior GO:0007610 9.33 HTR1A HTR2A HTR2C
30 response to drug GO:0042493 9.17 COMT CRH GATA3 HTR2A HTR2C SLC6A2
31 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR2C
32 signal transduction GO:0007165 10.24 CRH GATA3 HTR1A HTR2A HTR2C HTR7

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.63 CRH OXT POMC
2 G-protein coupled serotonin receptor activity GO:0004993 9.46 HTR1A HTR2A HTR2C HTR7
3 monoamine transmembrane transporter activity GO:0008504 9.43 SLC6A2 SLC6A4
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 9.4 TPH1 TPH2
5 dopamine:sodium symporter activity GO:0005330 9.37 SLC6A2 SLC6A4
6 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.32 HTR2A HTR2C
7 tryptophan 5-monooxygenase activity GO:0004510 9.26 TPH1 TPH2
8 neurotransmitter receptor activity GO:0030594 9.26 HTR1A HTR2A HTR2C HTR7
9 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR2C HTR7

Sources for Mental Depression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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