MCID: MNT002
MIFTS: 28

Mental Depression malady

Neuronal diseases category

Summaries for Mental Depression

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32MalaCards
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MalaCards: Mental Depression is related to hypertension and perry syndrome. An important gene associated with Mental Depression is DPP4 (dipeptidyl-peptidase 4), and among its related pathways are Insulin Processing and Asparagine N-linked glycosylation. The compounds phosphoramidon and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain.

Aliases & Classifications for Mental Depression

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Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mental depression 8 60


External Ids:

Disease Ontology8 DOID:1596
NCIt39 C2982
MeSH34 D003863

Related Diseases for Mental Depression

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mental Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension10.2
2perry syndrome10.1
3essential hypertension10.0
4chronic fatigue syndrome10.0POMC
5vitiligo10.0POMC
6schizophrenia10.0DPP4
7encephalomyelitis10.0DPP4
8skin disease10.0POMC
9multiple sclerosis10.0DPP4, POMC
10metabolic syndrome x10.0DPP4, POMC
11hypoglycemia10.0POMC, DPP4
12hyperglycemia10.0DPP4, POMC
13anorexia nervosa10.0DPP4, POMC
14parkinson's disease9.9
15crohn's disease9.9
16seasonal affective disorder9.9
17endogenous depression9.9
18heart cancer9.9
19sleep disorder9.9

Graphical network of diseases related to Mental Depression:



Diseases related to mental depression

Clinical Features for Mental Depression

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Drugs & Therapeutics for Mental Depression

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mental Depression

Drug clinical trials:

Search ClinicalTrials for Mental Depression

Search NIH Clinical Center for Mental Depression

Search CenterWatch for Mental Depression

Genetic Tests for Mental Depression

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Anatomical Context for Mental Depression

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Sources:
32MalaCards
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MalaCards organs/tissues related to Mental Depression:

32
Heart, Liver, Brain, Eye

Animal Models for Mental Depression or affiliated genes

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Publications for Mental Depression

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Sources:
50PubMed
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Articles related to Mental Depression:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. (23960245)
2014
2
Stigmatizing attitudes differ across mental health disorders: a comparison of stigma across eating disorders, obesity, and major depressive disorder. (23538972)
2013
3
Receiving workplace mental health accommodations and the outcome of mental disorders in employees with a depressive and/or anxiety disorder. (24164769)
2013
4
A meta-analysis of mental health treatments and cardiac rehabilitation for improving clinical outcomes and depression among patients with coronary heart disease. (23630306)
2013
5
Understanding Mental and Physical Fatigue Complaints in Those With Depression and Insomnia. (24128300)
2013
6
Postpartum depression predicts offspring mental health problems in adolescence independently of parental lifetime psychopathology. (21930302)
2012
7
PTSD'S mediation of the relationships between trauma, depression, substance abuse, mental health, and physical health in individuals with severe mental illness: evaluating a comprehensive model. (22104139)
2012
8
'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial. (23253305)
2012
9
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
10
Identifying mothers with postpartum depression early: integrating perinatal mental health care into the obstetric setting. (21941662)
2011
11
Prenatal and postnatal growth retardation, depressed nasal tip, oligodactyly, and mental retardation. (19940764)
2010
12
Religious moral beliefs as mental health protective factor of war veterans suffering from PTSD, depressiveness, anxiety, tobacco and alcohol abuse in comorbidity. (20562748)
2010
13
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. (19452408)
2009
14
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
15
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. (17959805)
2007
16
Mental health and pregnancy. The link between prenatal and postpartum depression. (19998999)
2007
17
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. (16447661)
2005
18
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. (15119163)
2004
19
Neopterin production, tryptophan degradation, and mental depression--what is the link? (12401473)
2002
20
Carbohydrate malabsorption syndromes and early signs of mental depression in females. (10961700)
2000
21
A heuristic model of mental depression derived from basic and applied research on thyrotropin-releasing hormone. (9827666)
1998
22
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. (9824144)
1998
23
Mental depression and death in elderly persons. (9465545)
1997
24
Psychosocial characteristics of adolescents with a past history of dysthymic disorder: comparison with adolescents with past histories of major depressive and non-affective disorders, and never mentally ill controls. (9105954)
1997
25
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. (8801470)
1996
26
Clinical observation on needling extrachannel points in treating mental depression. (8196410)
1994
27
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. (1999695)
1991
28
Nurses and shiftwork: effects on physical health and mental depression. (2394892)
1990
29
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. (2594736)
1989
30
Mental depression, acute infection and coma in a patient treated with interferon-alpha. (2501183)
1989
31
Mental depression is associated with malnutrition in patients with head and neck cancer. (3190874)
1988
32
Variations in serum vanadium levels during the treatment of mental depression. (3756279)
1986
33
Mental depression and kundalini yoga. (22557558)
1986
34
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. (7266825)
1981
35
Pathways to the cure of mental depression. (243281)
1977
36
Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). (320830)
1977
37
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4118700)
1972
38
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4116150)
1972
39
Parkinsonism, L-dopa and mental depression. (5421784)
1970
40
Chemotherapy of mental depression. (4913951)
1970
41
Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics. (5457617)
1970
42
Vitamin D intoxication, with hypernatraemia, potassium and water depletion, and mental depression. (5723727)
1968
43
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
44
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. (5962034)
1966
45
A CLINICAL EVALUATION OF PARGYLINE HYDROCHLORIDE (EUTONYL) IN THE MANAGEMENT OF MENTAL DEPRESSION. (14309088)
1965
46
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. (13983943)
1963
47
Treatment of recurrent mental depression with imipramine. (13862250)
1961
48
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. (13616942)
1958
49
Mental depression associated with hyperadrenocorticism. (13533641)
1958
50
Treatment of mental depression. (18126036)
1949

Genetic Variations for Mental Depression

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Expression for genes affiliated with Mental Depression

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for genes affiliated with Mental Depression

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Sources:
53Reactome
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Pathways related to Mental Depression according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3DPP4, POMC
2
Hide members
8.5DPP4, POMC, DCTN1

Compounds for genes affiliated with Mental Depression

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Mental Depression according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphoramidon44 1110.3DPP4, POMC
2cyclosporin a44 28 5911.3DPP4, POMC
3metformin44 49 1111.2DPP4, POMC
4glycerol44 11 2411.0DPP4, POMC

GO Terms for genes affiliated with Mental Depression

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16Gene Ontology
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Molecular functions related to Mental Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3DPP4, POMC

Products for genes affiliated with Mental Depression

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mental Depression

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet