MCID: MNT002
MIFTS: 60

Mental Depression

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Name: Mental Depression 12 14 69
Depression 41 59 28
Depressive Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1596
ICD10 32 F32.9 F33.9
MeSH 41 D003863
NCIt 46 C2982

Summaries for Mental Depression

PubMed Health : 59
About depression: We all feel sad or lethargic every now and then. And we have all felt down or even desperate at some point in our lives. These phases are a normal part of life, and people usually feel better again after a while. Things are different for people who have depression. Their sadness and negative thoughts last longer and overshadow all of their thoughts and actions. Depression can arise without any triggering events or for no apparent reasons. People often feel like they are stuck in a black hole. They feel cheerless, lack motivation and self-confidence, and think of themselves as worthless. This can make it difficult to do everyday things like going to work or studying. Friends, family and hobbies are often neglected. They don't sleep well.Depression can also make family and friends feel worried, anxious and helpless. Often they want to help but don't know how. It's not always easy for them to tell whether it's a passing phase or a serious illness.

MalaCards based summary : Mental Depression, also known as depression, is related to major depressive disorder and endogenous depression, and has symptoms including depressed - symptom, depression aggravated and depressed reaction. An important gene associated with Mental Depression is IER3IP1 (Immediate Early Response 3 Interacting Protein 1), and among its related pathways/superpathways are Neuroscience and Circadian rythm related genes. The drugs Citalopram and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Depression is a state of low mood and aversion to activity that can affect a person\'s thoughts,... more...

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 major depressive disorder 31.5 BDNF COMT CRH FKBP5 GATA3 HTR1A
2 endogenous depression 30.9 BDNF CRH GATA3 HTR1A HTR2A IER3IP1
3 perry syndrome 11.8
4 alzheimer disease 5 10.5 HTR2A SLC6A4
5 schizophrenia 5 10.5 HTR1A HTR2A
6 schizoid personality disorder 10.5 HTR1A HTR2A
7 hypoactive sexual desire disorder 10.5 HTR1A HTR2A
8 substance-induced psychosis 10.5 HTR1A HTR2A
9 pathological gambling 10.4 HTR2A MAOA SLC6A4
10 rumination disorder 10.4 HTR1A HTR7
11 intermittent explosive disorder 10.4 HTR1A HTR7 SLC6A4
12 drug-induced mental disorder 10.4 HTR1A HTR2A HTR7
13 drug psychosis 10.4 HTR1A HTR2A HTR7
14 alexithymia 10.4 COMT HTR1A SLC6A4
15 phobia, specific 10.4 COMT MAOA
16 retrograde amnesia 10.3 POMC SLC6A4
17 irritable bowel syndrome 10.3 CRH HTR7 SLC6A4
18 hypothalamic disease 10.3 CRH POMC
19 antisocial personality disorder 10.3 COMT MAOA SLC6A4
20 conduct disorder 10.3 COMT MAOA SLC6A4
21 agoraphobia 10.3 HTR1A MAOA SLC6A2 SLC6A4
22 coronary artery vasospasm 10.3 HTR2A HTR7
23 glucose metabolism disease 10.3 DPP4 IER3IP1 POMC PSMD9
24 withdrawal disorder 10.3 CRH HTR7 POMC
25 periodic limb movement disorder 10.3 HTR1A HTR2A HTR2C SLC6A4
26 acquired metabolic disease 10.3 DPP4 IER3IP1 POMC PSMD9
27 acth deficiency, isolated 10.3 CRH POMC
28 pervasive developmental disorder 10.3 BDNF OXT SLC6A4
29 phobic disorder 10.3 COMT HTR1A MAOA SLC6A4
30 avoidant personality disorder 10.2 CRH MAOA WASF1
31 drug dependence 10.2 BDNF CRH POMC SLC6A4
32 substance dependence 10.2 BDNF MAOA POMC SLC6A4
33 schizoaffective disorder 10.2 BDNF COMT HTR2A SLC6A4
34 substance abuse 10.2 BDNF COMT MAOA SLC6A4
35 amnestic disorder 10.2 BDNF HTR1A HTR7 POMC
36 pituitary carcinoma 10.2 CRH POMC
37 premenstrual tension 10.2 CRH OXT POMC
38 premature ejaculation 10.2 COMT HTR1A HTR2C SLC6A4
39 central nervous system disease 10.2 BDNF HTR2A IER3IP1 SLC6A2 SLC6A4
40 kleine-levin hibernation syndrome 10.2 COMT HTR7 POMC
41 kleptomania 10.2 GATA3 HTR1A HTR7 MAOA SLC6A4
42 dysthymic disorder 10.2 GATA3 HTR2A HTR7 MAOA SLC6A4
43 atypical depressive disorder 10.2 CRH GATA3 HTR7 MAOA SLC6A4
44 childhood disintegrative disease 10.2 BDNF POMC
45 psychosexual disorder 10.1 HTR1A HTR2A HTR2C HTR7 SLC6A4
46 early-onset schizophrenia 10.1 BDNF COMT HTR2A MAOA SLC6A4
47 pain agnosia 10.1 HTR7 IER3IP1 OXT POMC
48 agnosia 10.1 HTR7 IER3IP1 OXT POMC
49 serotonin syndrome 10.1 HTR1A HTR2A MAOA OXT SLC6A4
50 melancholia 10.1 CRH IER3IP1

Graphical network of the top 20 diseases related to Mental Depression:



Diseases related to Mental Depression

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:


depressed - symptom, depression aggravated, depressed reaction, dejection emotional, depressive symptoms, schizophrenic language, behavioral symptoms, affective symptoms

MGI Mouse Phenotypes related to Mental Depression:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.27 SLC6A2 SLC6A4 TPH2 WASF1 POMC BDNF
2 homeostasis/metabolism MP:0005376 10.16 POMC SLC6A2 SLC6A4 TPH2 GATA3 BDNF
3 endocrine/exocrine gland MP:0005379 9.97 POMC SLC6A4 OXT GATA3 BDNF HTR2A
4 adipose tissue MP:0005375 9.88 POMC TPH2 OXT GATA3 HTR2C CRH
5 integument MP:0010771 9.85 POMC SLC6A2 SLC6A4 TPH2 OXT GATA3
6 mortality/aging MP:0010768 9.77 POMC SLC6A2 SLC6A4 TPH2 WASF1 OXT
7 nervous system MP:0003631 9.5 POMC SLC6A2 SLC6A4 TPH2 WASF1 BDNF

Drugs & Therapeutics for Mental Depression

PubMedHealth treatment related to Mental Depression: 59

Many people who have depression find it hard to accept that fact. One possible reason for this is that they are ashamed about having a mental health problem and don't want their friends, family and colleagues to find out. Some people don't want to have treatment as a result. But treatment can often shorten depressive episodes and relieve people's symptoms.There are various treatment options for depression. The main treatments are psychological treatment, such as cognitive behavioral therapy, and/or medication. Which type of treatment is the most appropriate, where it should take place and how long it lasts will depend on several factors, including how severe the person’s depression is, their personal circumstances, and how their symptoms develop over time. People can talk to a therapist about the advantages and disadvantages of the possible treatments, as well as what they expect from treatment and any fears they might have.

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1153)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59729-33-8 2771
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
4
Clonazepam Approved, Illicit Phase 4,Phase 3,Phase 2,Early Phase 1 1622-61-3 2802
5
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79617-96-2 68617
6
Tranylcypromine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 155-09-9 441233
7
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34911-55-2, 34841-39-9 444
8
Ropinirole Approved, Investigational Phase 4,Phase 3,Phase 2 91374-20-8, 91374-21-9 5095 497540
9
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-23-7 657311 5754
10
Copper Approved, Investigational Phase 4,Phase 3 7440-50-8 27099
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757
12
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 1 57-63-6 5991
13
Norethindrone Approved Phase 4 68-22-4 6230
14
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-45-6, 75614-87-8 774
15
Mianserin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24219-97-4 4184
16
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85650-52-8, 61337-67-5 4205
17
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
18
Buspirone Approved, Investigational Phase 4,Phase 3,Phase 2 36505-84-7 2477
19
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
20
Reboxetine Approved, Investigational Phase 4,Phase 3,Phase 2 71620-89-8, 98769-81-4 65856 123628
21
Eszopiclone Approved, Investigational Phase 4,Phase 3,Phase 2 138729-47-2 969472
22
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
23
Nortriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1 72-69-5 4543
24
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1 58-39-9 4748
25
Trimipramine Approved Phase 4,Phase 3 739-71-9 5584 4055
26
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
27
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54910-89-3 3386
28
Lactulose Approved Phase 4 4618-18-2 11333
29
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
30
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-73-1, 147-24-0 3100
31
Promethazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-87-7 4927
32
Suvorexant Approved, Investigational Phase 4 1030377-33-3
33
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
34
Methyltestosterone Approved Phase 4,Phase 3,Phase 2 58-18-4 6010
35
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2 58-22-0 6013
36
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 616-91-1 12035
37
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
38
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 2078-54-8 4943
39
Succinylcholine Approved Phase 4,Phase 3 306-40-1 5314
40
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
41
Fluvoxamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 54739-18-3 5324346 3404
42
Trazodone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 19794-93-5 5533
43
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
44
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
45
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
46
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
47
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
48
Rilpivirine Approved Phase 4 500287-72-9
49
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
50
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816

Interventional clinical trials:

(show top 50) (show all 10000)

# Name Status NCT ID Phase Drugs
1 The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
2 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care Unknown status NCT00939250 Phase 4
3 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
4 Inflammatory Markers and Cognitive Function in Major Depression Unknown status NCT01391221 Phase 4 Duloxetine
5 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4 Drug treatment with Cymbalta
6 Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression Unknown status NCT01390662 Phase 4
7 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
8 Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Unknown status NCT00442429 Phase 4
9 DECARD: Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
10 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
11 Lithium and Standard Therapy in Resistant Depression Unknown status NCT00927550 Phase 4 lithium;usual care
12 Efficacy Study of Escitalopram for Depression in Patients With Diabetes Unknown status NCT00650897 Phase 4 Escitalopram
13 Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4 Desvenlafaxine Succinate
14 Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
15 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4 Tranylcypromine
16 Depression Care Management for Depressed Elders in China Primary Care Unknown status NCT01287494 Phase 4 Sertraline
17 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
18 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
19 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
20 Medications for the Treatment of Dysthymic Disorder and Double Depression Unknown status NCT00234312 Phase 4 escitalopram and sertraline
21 Duloxetine for Major Depression in Peri-/Postmenopausal Women Unknown status NCT00889369 Phase 4 Duloxetine
22 Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression Unknown status NCT00106197 Phase 4 Bupropion
23 Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients Unknown status NCT02213016 Phase 4
24 Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales Unknown status NCT02210702 Phase 4 Ethinyl Estradiol 35mcg/Norethindrone 1mg;Ethinyl Estradiol 20mcg/Norethindrone 1mg
25 Estrogen and Perimenopausal Depression Unknown status NCT00229450 Phase 4 estrogen
26 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
27 Effect of Antidepressants on White Matter Structure Unknown status NCT01492621 Phase 4 Desvenlafaxine
28 Efficacy of MBI for Depressive Symptoms in Patients With MS Unknown status NCT02611401 Phase 4
29 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
30 Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
31 Efficacy Study of Botox for Depression Unknown status NCT01556971 Phase 4 Botox;Saline Solution
32 Treatment of Mild and Subthreshold Depressive Disorders Unknown status NCT00226642 Phase 4 Sertralin;Placebo
33 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
34 Benefits of Switching Antidepressants Following Early Nonresponse Unknown status NCT00519012 Phase 4 Sertraline to Paroxetine;Paroxetine to Sertraline
35 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
36 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
37 Clinical Pharmacogenomics of Antidepressant Response Unknown status NCT00269334 Phase 4 Using Citalopram(drug) or Paroxetine(drug)
38 Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Unknown status NCT02237937 Phase 4 Paroxetine;Sertraline;Citalopram;Venlafaxine;Amitriptyline;Escitalopram;Amitriptylinoxide;Nortriptyline;Trimipramine
39 Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
40 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
41 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
42 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN) Unknown status NCT02051413 Phase 4 Venlafaxine extended release
43 Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study Unknown status NCT00785603 Phase 4 Paroxetine;Paroxetin placebo;Tramadol
44 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
45 Agomelatine Treatment of Depression in Schizophrenia (AGOPSYCH) Unknown status NCT01822418 Phase 4 agomelatine
46 Aripiprazole (Abilify®) as an Adjunctive Treatment for Inadequate Response in Major Depressive Disorder Unknown status NCT01696617 Phase 4 Aripiprazole 6-week group;Aripiprazole 8-week group
47 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido
48 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
49 Paliperidone ER(Invega®) on Depressive Symptoms of Schizophrenia Patients Unknown status NCT01399450 Phase 4 paliperidone
50 Lexapro®'s Efficacy After Dose Escalation in Remission Study Unknown status NCT01594866 Phase 4 escitalopram;escitalopram

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: depression

Genetic Tests for Mental Depression

Genetic tests related to Mental Depression:

# Genetic test Affiliating Genes
1 Depression 28

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

38
Brain, Heart, Testes, Lung, Prostate, Spinal Cord, Bone

Publications for Mental Depression

Articles related to Mental Depression:

(show top 50) (show all 56)
# Title Authors Year
1
Social support and breast cancer: A comparatory study of breast cancer survivors, women with mental depression, women with hypertension and healthy female controls. ( 28667868 )
2017
2
Correlates of Mental Depression Among Female Sex Workers in Southern India. ( 26307144 )
2015
3
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. ( 21384741 )
2010
4
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. ( 19452408 )
2009
5
A controlled study on treatment of mental depression by acupuncture plus TCM medication. ( 17955648 )
2007
6
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. ( 16447661 )
2005
7
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. ( 15119163 )
2004
8
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. ( 15510791 )
2004
9
DPP IV and mental depression in Crohn's disease. ( 12675254 )
2003
10
Neopterin production, tryptophan degradation, and mental depression--what is the link? ( 12401473 )
2002
11
Carbohydrate malabsorption syndromes and early signs of mental depression in females. ( 10961700 )
2000
12
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. ( 9824144 )
1998
13
A heuristic model of mental depression derived from basic and applied research on thyrotropin-releasing hormone. ( 9827666 )
1998
14
Fructose malabsorption is associated with early signs of mental depression. ( 9620891 )
1998
15
Mental depression and death in elderly persons. ( 9465545 )
1997
16
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. ( 8801470 )
1996
17
Clinical observation on needling extrachannel points in treating mental depression. ( 8196410 )
1994
18
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. ( 1999695 )
1991
19
Nurses and shiftwork: effects on physical health and mental depression. ( 2394892 )
1990
20
Mental depression, acute infection and coma in a patient treated with interferon-alpha. ( 2501183 )
1989
21
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. ( 2594736 )
1989
22
Mental depression is associated with malnutrition in patients with head and neck cancer. ( 3190874 )
1988
23
Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression. ( 3351130 )
1988
24
Mental depression in untreated Parkinson's disease of recent onset. ( 3825724 )
1987
25
Variations in serum vanadium levels during the treatment of mental depression. ( 3756279 )
1986
26
Mental depression and kundalini yoga. ( 22557558 )
1986
27
Seasonal variation in mental depression and its correlation with occupation. ( 3726602 )
1986
28
Platelet serotonin in essential hypertension and in mental depression. ( 2412030 )
1985
29
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. ( 7266825 )
1981
30
Mental depression secondary to fluorouracil therapy for actinic keratoses. ( 7425651 )
1980
31
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. ( 43704 )
1979
32
Solvent exposure and mental depression. ( 509886 )
1979
33
Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). ( 320830 )
1977
34
Pathways to the cure of mental depression. ( 243281 )
1977
35
Biochemistry of mental depression. ( 23214 )
1977
36
Antinuclear factor-positive mental depression: a single disease entity? ( 1083254 )
1976
37
Hereditary mental depression and Parkinsonism with taurine deficiency. ( 1122173 )
1975
38
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4116150 )
1972
39
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4118700 )
1972
40
Parkinsonism, L-dopa and mental depression. ( 5421784 )
1970
41
Chemotherapy of mental depression. ( 4913951 )
1970
42
Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics. ( 5457617 )
1970
43
Vitamin D intoxication, with hypernatraemia, potassium and water depletion, and mental depression. ( 5723727 )
1968
44
Desipramine and nortriptyline in mental depression. ( 5325569 )
1966
45
Psychopharmacological aspects of mental depression. ( 5328330 )
1966
46
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. ( 5962034 )
1966
47
A CLINICAL EVALUATION OF PARGYLINE HYDROCHLORIDE (EUTONYL) IN THE MANAGEMENT OF MENTAL DEPRESSION. ( 14309088 )
1965
48
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. ( 13983943 )
1963
49
Treatment of recurrent mental depression with imipramine. ( 13862250 )
1961
50
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. ( 13616942 )
1958

Variations for Mental Depression

Expression for Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.33 COMT DCTN1 HTR1A POMC TPH2
3 11.91 BDNF GATA3 HTR1A HTR2A MAOA SLC6A4
4 11.77 GATA3 MAOA POMC
5
Show member pathways
11.73 HTR1A HTR2A HTR2C HTR7
6 11.58 FKBP5 GATA3 POMC
7
Show member pathways
11.55 COMT SLC6A2 SLC6A4
8 11.55 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
9
Show member pathways
11.19 MAOA SLC6A2 SLC6A4 TPH2
10
Show member pathways
10.91 COMT MAOA SLC6A4
11
Show member pathways
10.7 COMT MAOA
12 10.66 COMT MAOA
13 10.61 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
14 10.28 CRH POMC

GO Terms for Mental Depression

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.81 COMT CRH OXT
2 circadian rhythm GO:0007623 9.8 HTR7 SLC6A4 TPH2
3 chemical synaptic transmission GO:0007268 9.8 CRH HTR2A HTR2C HTR7 SLC6A2
4 memory GO:0007613 9.75 HTR2A OXT SLC6A4
5 behavioral fear response GO:0001662 9.65 DPP4 HTR1A HTR2C
6 locomotory exploration behavior GO:0035641 9.63 CRH DPP4
7 sleep GO:0030431 9.62 HTR2A OXT
8 neurotransmitter catabolic process GO:0042135 9.62 COMT MAOA
9 catecholamine metabolic process GO:0006584 9.61 COMT MAOA
10 regulation of appetite GO:0032098 9.61 HTR2C POMC
11 regulation of behavior GO:0050795 9.59 HTR1A HTR2A
12 monoamine transport GO:0015844 9.58 SLC6A2 SLC6A4
13 dopamine catabolic process GO:0042420 9.57 COMT MAOA
14 dopamine uptake involved in synaptic transmission GO:0051583 9.56 SLC6A2 SLC6A4
15 response to estrogen GO:0043627 9.56 COMT CRH GATA3 TPH2
16 sperm ejaculation GO:0042713 9.55 OXT SLC6A4
17 regulation of hormone secretion GO:0046883 9.54 HTR1A HTR2A
18 response to pain GO:0048265 9.54 COMT CRH SLC6A2
19 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.52 HTR2A HTR2C
20 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.51 HTR1A HTR7
21 vasoconstriction GO:0042310 9.5 HTR1A HTR7 SLC6A4
22 response to ether GO:0045472 9.49 CRH OXT
23 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.46 HTR2A HTR2C
24 regulation of serotonin secretion GO:0014062 9.43 CRH HTR1A
25 behavior GO:0007610 9.33 HTR1A HTR2A HTR2C
26 response to drug GO:0042493 9.17 COMT CRH GATA3 HTR2A HTR2C SLC6A2
27 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR2C
28 G-protein coupled receptor signaling pathway GO:0007186 10.14 CRH HTR1A HTR2A HTR2C HTR7 OXT

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 CRH OXT POMC
2 neuropeptide hormone activity GO:0005184 9.5 CRH OXT POMC
3 neurotransmitter receptor activity GO:0030594 9.46 HTR1A HTR2A HTR2C HTR7
4 monoamine transmembrane transporter activity GO:0008504 9.4 SLC6A2 SLC6A4
5 dopamine:sodium symporter activity GO:0005330 9.37 SLC6A2 SLC6A4
6 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.26 HTR2A HTR2C
7 G-protein coupled serotonin receptor activity GO:0004993 9.26 HTR1A HTR2A HTR2C HTR7
8 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR2C HTR7

Sources for Mental Depression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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50 NINDS
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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