MCID: MNT002
MIFTS: 21

Mental Depression malady

Summaries for Mental Depression

Sources:
33MalaCards
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MalaCards: Mental Depression is related to perry syndrome and chronic fatigue syndrome. An important gene associated with Mental Depression is DPP4 (dipeptidyl-peptidase 4), and among its related pathways are Insulin Processing and Asparagine N-linked glycosylation. The compounds phosphoramidon and cyclosporin a have been mentioned in the context of this disorder.

Aliases & Classifications for Mental Depression

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

mental depression 8 61


External Ids:

Disease Ontology8 DOID:1596
NCIt40 C2982
MeSH35 D003863

Related Diseases for Mental Depression

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mental Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1perry syndrome10.2
2chronic fatigue syndrome10.0POMC
3vitiligo10.0POMC
4schizophrenia10.0DPP4
5encephalomyelitis10.0DPP4
6skin disease10.0POMC
7multiple sclerosis10.0DPP4, POMC
8metabolic syndrome x10.0POMC, DPP4
9hypoglycemia10.0POMC, DPP4
10hyperglycemia10.0POMC, DPP4
11anorexia nervosa10.0DPP4, POMC
12seasonal affective disorder9.9
13sleep disorder9.9

Graphical network of diseases related to Mental Depression:



Diseases related to mental depression

Clinical Features for Mental Depression

Drugs & Therapeutics for Mental Depression

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mental Depression

Drug clinical trials:

Search ClinicalTrials for Mental Depression

Search NIH Clinical Center for Mental Depression

Search CenterWatch for Mental Depression

Genetic Tests for Mental Depression

Anatomical Context for Mental Depression

Animal Models for Mental Depression or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mental Depression

Sources:
51PubMed
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Articles related to Mental Depression:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
2
Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece. (23963406)
2013
3
Service use and barriers to mental health care among adults with major depression and comorbid substance dependence. (23728427)
2013
4
Understanding Mental and Physical Fatigue Complaints in Those With Depression and Insomnia. (24128300)
2013
5
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. (22539853)
2012
6
Postpartum depression predicts offspring mental health problems in adolescence independently of parental lifetime psychopathology. (21930302)
2012
7
PTSD'S mediation of the relationships between trauma, depression, substance abuse, mental health, and physical health in individuals with severe mental illness: evaluating a comprehensive model. (22104139)
2012
8
Are mental health problems and depression associated with bruxism in children? (22049927)
2012
9
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
10
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. (21384741)
2010
11
A Case of Treatment Resistant Depression and Alcohol Abuse in a Person with Mental Retardation: Response to Aripiprazole and Fluvoxamine Therapy upon Consideration of a Bipolar Diathesis after Repetitive Failure to Respond to Multiple Antidepressant Trials. (21274287)
2010
12
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. (19452408)
2009
13
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. (17959805)
2007
14
A controlled study on treatment of mental depression by acupuncture plus TCM medication. (17955648)
2007
15
Mental health and pregnancy. The link between prenatal and postpartum depression. (19998999)
2007
16
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. (16447661)
2005
17
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. (15119163)
2004
18
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. (15510791)
2004
19
DPP IV and mental depression in Crohn's disease. (12675254)
2003
20
Neopterin production, tryptophan degradation, and mental depression--what is the link? (12401473)
2002
21
Carbohydrate malabsorption syndromes and early signs of mental depression in females. (10961700)
2000
22
Fructose malabsorption is associated with early signs of mental depression. (9620891)
1998
23
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. (9824144)
1998
24
Mental depression and death in elderly persons. (9465545)
1997
25
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. (8801470)
1996
26
Clinical observation on needling extrachannel points in treating mental depression. (8196410)
1994
27
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. (1999695)
1991
28
Mental health locus of control in agoraphobia and depression: a longitudinal study of inpatients. (1891526)
1991
29
Nurses and shiftwork: effects on physical health and mental depression. (2394892)
1990
30
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. (2594736)
1989
31
Variations in serum vanadium levels during the treatment of mental depression. (3756279)
1986
32
Platelet serotonin in essential hypertension and in mental depression. (2412030)
1985
33
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. (7266825)
1981
34
Mental depression secondary to fluorouracil therapy for actinic keratoses. (7425651)
1980
35
Solvent exposure and mental depression. (509886)
1979
36
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. (43704)
1979
37
Biochemistry of mental depression. (23214)
1977
38
Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). (320830)
1977
39
Antinuclear factor-positive mental depression: a single disease entity? (1083254)
1976
40
Hereditary mental depression and Parkinsonism with taurine deficiency. (1122173)
1975
41
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4118700)
1972
42
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4116150)
1972
43
Parkinsonism, L-dopa and mental depression. (5421784)
1970
44
Vitamin D intoxication, with hypernatraemia, potassium and water depletion, and mental depression. (5723727)
1968
45
Psychopharmacological aspects of mental depression. (5328330)
1966
46
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. (13616942)
1958
47
Treatment of mental depression. (18126036)
1949
48
The effects of bilateral stellate ganglion block on mental depression; report of 3 cases. (20250097)
1947
49
Observations on changes in states of mental depression and tension following surgical section of certain frontal lobe pathways. (21003249)
1946
50
Royal Berkshire Hospital: Compound fracture of the femur-sudden death apparently caused by mental depression. (21379749)
1841

Genetic Variations for Mental Depression

Expression for genes affiliated with Mental Depression

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for genes affiliated with Mental Depression

Sources:
54Reactome
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Pathways related to Mental Depression according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3DPP4, POMC
2
Hide members
8.5DPP4, POMC, DCTN1

Compounds for genes affiliated with Mental Depression

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Mental Depression according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphoramidon45 1110.3DPP4, POMC
2cyclosporin a45 29 6011.3DPP4, POMC
3metformin45 50 1111.2DPP4, POMC
4glycerol45 11 2411.0DPP4, POMC

GO Terms for genes affiliated with Mental Depression

Sources:
16Gene Ontology
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Molecular functions related to Mental Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3DPP4, POMC

Products for genes affiliated with Mental Depression

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mental Depression

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet