MCID: MNT002
MIFTS: 28

Mental Depression malady

Neuronal diseases category

Summaries for Mental Depression

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Mental Depression is related to hypertension and perry syndrome. An important gene associated with Mental Depression is DPP4 (dipeptidyl-peptidase 4), and among its related pathways are Insulin Processing and Asparagine N-linked glycosylation. The compounds phosphoramidon and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and brain.

Aliases & Classifications for Mental Depression

About this section
Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mental depression 8 60


External Ids:

Disease Ontology8 DOID:1596
NCIt39 C2982
MeSH34 D003863

Related Diseases for Mental Depression

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mental Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension10.2
2perry syndrome10.1
3essential hypertension10.0
4chronic fatigue syndrome10.0POMC
5vitiligo10.0POMC
6schizophrenia10.0DPP4
7encephalomyelitis10.0DPP4
8skin disease10.0POMC
9multiple sclerosis10.0DPP4, POMC
10metabolic syndrome x10.0DPP4, POMC
11hypoglycemia10.0POMC, DPP4
12hyperglycemia10.0DPP4, POMC
13anorexia nervosa10.0DPP4, POMC
14parkinson's disease9.9
15crohn's disease9.9
16seasonal affective disorder9.9
17endogenous depression9.9
18heart cancer9.9
19sleep disorder9.9

Graphical network of diseases related to Mental Depression:



Diseases related to mental depression

Clinical Features for Mental Depression

About this section

Drugs & Therapeutics for Mental Depression

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mental Depression

Drug clinical trials:

Search ClinicalTrials for Mental Depression

Search NIH Clinical Center for Mental Depression

Search CenterWatch for Mental Depression

Genetic Tests for Mental Depression

About this section

Anatomical Context for Mental Depression

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mental Depression:

32
Heart, Eye, Brain, Liver

Animal Models for Mental Depression or affiliated genes

About this section

Publications for Mental Depression

About this section
Sources:
50PubMed
See all sources

Articles related to Mental Depression:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Self-harm in postpartum depression and referrals to a perinatal mental health team: an audit study. (23462983)
2013
2
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
3
Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease. (24163385)
2013
4
Receiving workplace mental health accommodations and the outcome of mental disorders in employees with a depressive and/or anxiety disorder. (24164769)
2013
5
Mentalizing in female inpatients with major depressive disorder. (23407204)
2013
6
Irritable mood in adult major depressive disorder: results from the world mental health surveys. (23364997)
2013
7
A meta-analysis of mental health treatments and cardiac rehabilitation for improving clinical outcomes and depression among patients with coronary heart disease. (23630306)
2013
8
Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece. (23963406)
2013
9
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. (22539853)
2012
10
Postpartum depression predicts offspring mental health problems in adolescence independently of parental lifetime psychopathology. (21930302)
2012
11
PTSD'S mediation of the relationships between trauma, depression, substance abuse, mental health, and physical health in individuals with severe mental illness: evaluating a comprehensive model. (22104139)
2012
12
Are mental health problems and depression associated with bruxism in children? (22049927)
2012
13
'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial. (23253305)
2012
14
Prenatal and postnatal growth retardation, depressed nasal tip, oligodactyly, and mental retardation. (19940764)
2010
15
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. (21384741)
2010
16
A Case of Treatment Resistant Depression and Alcohol Abuse in a Person with Mental Retardation: Response to Aripiprazole and Fluvoxamine Therapy upon Consideration of a Bipolar Diathesis after Repetitive Failure to Respond to Multiple Antidepressant Trials. (21274287)
2010
17
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. (19452408)
2009
18
Stigma towards mental illness: a concept analysis using postpartum depression as an exemplar. (18214776)
2008
19
A controlled study on treatment of mental depression by acupuncture plus TCM medication. (17955648)
2007
20
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. (16908410)
2006
21
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. (15119163)
2004
22
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. (15510791)
2004
23
DPP IV and mental depression in Crohn's disease. (12675254)
2003
24
Fructose malabsorption is associated with early signs of mental depression. (9620891)
1998
25
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. (9824144)
1998
26
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. (8801470)
1996
27
Mental health locus of control in agoraphobia and depression: a longitudinal study of inpatients. (1891526)
1991
28
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. (2594736)
1989
29
Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression. (3351130)
1988
30
Variations in serum vanadium levels during the treatment of mental depression. (3756279)
1986
31
Seasonal variation in mental depression and its correlation with occupation. (3726602)
1986
32
Platelet serotonin in essential hypertension and in mental depression. (2412030)
1985
33
Staff ratings of elderly at day care centers: mental status, hypochondriasis, depression. (10267681)
1982
34
Mental depression secondary to fluorouracil therapy for actinic keratoses. (7425651)
1980
35
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. (43704)
1979
36
Biochemistry of mental depression. (23214)
1977
37
Antinuclear factor-positive mental depression: a single disease entity? (1083254)
1976
38
Hereditary mental depression and Parkinsonism with taurine deficiency. (1122173)
1975
39
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4116150)
1972
40
Parkinsonism, L-dopa and mental depression. (5421784)
1970
41
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
42
Mental hospital admissions for rural districts of England and Wales (1950-60) for all diagnoses, manic depressive reaction and involutional melancholia. (6072053)
1967
43
Desipramine and nortriptyline in mental depression. (5325569)
1966
44
Psychopharmacological aspects of mental depression. (5328330)
1966
45
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. (13983943)
1963
46
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. (13616942)
1958
47
Mental depression in hypertensive patients treated for long periods with large doses of reserpine. (13214379)
1954
48
The effects of bilateral stellate ganglion block on mental depression; report of 3 cases. (20250097)
1947
49
Observations on changes in states of mental depression and tension following surgical section of certain frontal lobe pathways. (21003249)
1946
50
Royal Berkshire Hospital: Compound fracture of the femur-sudden death apparently caused by mental depression. (21379749)
1841

Genetic Variations for Mental Depression

About this section

Expression for genes affiliated with Mental Depression

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for genes affiliated with Mental Depression

About this section
Sources:
53Reactome
See all sources

Pathways related to Mental Depression according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3DPP4, POMC
2
Hide members
8.5DPP4, POMC, DCTN1

Compounds for genes affiliated with Mental Depression

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB
See all sources

Compounds related to Mental Depression according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphoramidon44 1110.3DPP4, POMC
2cyclosporin a44 28 5911.3DPP4, POMC
3metformin44 49 1111.2DPP4, POMC
4glycerol44 11 2411.0DPP4, POMC

GO Terms for genes affiliated with Mental Depression

About this section
Sources:
16Gene Ontology
See all sources

Molecular functions related to Mental Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3DPP4, POMC

Products for genes affiliated with Mental Depression

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mental Depression

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet