MCID: MNT002
MIFTS: 28

Mental Depression malady

Neuronal diseases category

Summaries for Mental Depression

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32MalaCards
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MalaCards: Mental Depression is related to hypertension and perry syndrome. An important gene associated with Mental Depression is DPP4 (dipeptidyl-peptidase 4), and among its related pathways are Insulin Processing and Asparagine N-linked glycosylation. The compounds phosphoramidon and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and brain.

Aliases & Classifications for Mental Depression

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Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mental depression 8 60


External Ids:

Disease Ontology8 DOID:1596
NCIt39 C2982
MeSH34 D003863

Related Diseases for Mental Depression

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mental Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension10.2
2perry syndrome10.1
3essential hypertension10.0
4chronic fatigue syndrome10.0POMC
5vitiligo10.0POMC
6schizophrenia10.0DPP4
7encephalomyelitis10.0DPP4
8skin disease10.0POMC
9multiple sclerosis10.0DPP4, POMC
10metabolic syndrome x10.0DPP4, POMC
11hypoglycemia10.0POMC, DPP4
12hyperglycemia10.0DPP4, POMC
13anorexia nervosa10.0DPP4, POMC
14parkinson's disease9.9
15crohn's disease9.9
16seasonal affective disorder9.9
17endogenous depression9.9
18heart cancer9.9
19sleep disorder9.9

Graphical network of diseases related to Mental Depression:



Diseases related to mental depression

Clinical Features for Mental Depression

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Drugs & Therapeutics for Mental Depression

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mental Depression

Drug clinical trials:

Search ClinicalTrials for Mental Depression

Search NIH Clinical Center for Mental Depression

Search CenterWatch for Mental Depression

Genetic Tests for Mental Depression

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Anatomical Context for Mental Depression

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Sources:
32MalaCards
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MalaCards organs/tissues related to Mental Depression:

32
Heart, Eye, Brain, Liver

Animal Models for Mental Depression or affiliated genes

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Publications for Mental Depression

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Sources:
50PubMed
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Articles related to Mental Depression:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Self-harm in postpartum depression and referrals to a perinatal mental health team: an audit study. (23462983)
2013
2
Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease. (24163385)
2013
3
Receiving workplace mental health accommodations and the outcome of mental disorders in employees with a depressive and/or anxiety disorder. (24164769)
2013
4
Mentalizing in female inpatients with major depressive disorder. (23407204)
2013
5
A meta-analysis of mental health treatments and cardiac rehabilitation for improving clinical outcomes and depression among patients with coronary heart disease. (23630306)
2013
6
Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece. (23963406)
2013
7
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. (22539853)
2012
8
Postpartum depression predicts offspring mental health problems in adolescence independently of parental lifetime psychopathology. (21930302)
2012
9
PTSD'S mediation of the relationships between trauma, depression, substance abuse, mental health, and physical health in individuals with severe mental illness: evaluating a comprehensive model. (22104139)
2012
10
'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial. (23253305)
2012
11
Prenatal and postnatal growth retardation, depressed nasal tip, oligodactyly, and mental retardation. (19940764)
2010
12
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. (21384741)
2010
13
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. (19452408)
2009
14
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
15
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. (17959805)
2007
16
A controlled study on treatment of mental depression by acupuncture plus TCM medication. (17955648)
2007
17
Mental health and pregnancy. The link between prenatal and postpartum depression. (19998999)
2007
18
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. (16908410)
2006
19
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. (16447661)
2005
20
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. (15119163)
2004
21
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. (15510791)
2004
22
DPP IV and mental depression in Crohn's disease. (12675254)
2003
23
Neopterin production, tryptophan degradation, and mental depression--what is the link? (12401473)
2002
24
Carbohydrate malabsorption syndromes and early signs of mental depression in females. (10961700)
2000
25
A heuristic model of mental depression derived from basic and applied research on thyrotropin-releasing hormone. (9827666)
1998
26
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. (9824144)
1998
27
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. (8801470)
1996
28
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. (1999695)
1991
29
Mental health locus of control in agoraphobia and depression: a longitudinal study of inpatients. (1891526)
1991
30
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. (2594736)
1989
31
Mental depression, acute infection and coma in a patient treated with interferon-alpha. (2501183)
1989
32
Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression. (3351130)
1988
33
Variations in serum vanadium levels during the treatment of mental depression. (3756279)
1986
34
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. (7266825)
1981
35
Biochemistry of mental depression. (23214)
1977
36
Hereditary mental depression and Parkinsonism with taurine deficiency. (1122173)
1975
37
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4118700)
1972
38
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. (4116150)
1972
39
Parkinsonism, L-dopa and mental depression. (5421784)
1970
40
Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics. (5457617)
1970
41
Mental hospital admissions in England and Wales 1950-60 for all diagnoses, manic depressive reaction and involutional melancholia. (6072175)
1967
42
Mental hospital admissions for rural districts of England and Wales (1950-60) for all diagnoses, manic depressive reaction and involutional melancholia. (6072053)
1967
43
Desipramine and nortriptyline in mental depression. (5325569)
1966
44
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. (5962034)
1966
45
A CLINICAL EVALUATION OF PARGYLINE HYDROCHLORIDE (EUTONYL) IN THE MANAGEMENT OF MENTAL DEPRESSION. (14309088)
1965
46
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. (13983943)
1963
47
Treatment of recurrent mental depression with imipramine. (13862250)
1961
48
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression. (13616942)
1958
49
The effects of bilateral stellate ganglion block on mental depression; report of 3 cases. (20250097)
1947
50
Royal Berkshire Hospital: Compound fracture of the femur-sudden death apparently caused by mental depression. (21379749)
1841

Genetic Variations for Mental Depression

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Expression for genes affiliated with Mental Depression

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for genes affiliated with Mental Depression

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Sources:
53Reactome
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Pathways related to Mental Depression according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3DPP4, POMC
2
Hide members
8.5DPP4, POMC, DCTN1

Compounds for genes affiliated with Mental Depression

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Mental Depression according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphoramidon44 1110.3DPP4, POMC
2cyclosporin a44 28 5911.3DPP4, POMC
3metformin44 49 1111.2DPP4, POMC
4glycerol44 11 2411.0DPP4, POMC

GO Terms for genes affiliated with Mental Depression

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16Gene Ontology
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Molecular functions related to Mental Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3DPP4, POMC

Products for genes affiliated with Mental Depression

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mental Depression

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet