MR
MCID: MNT147
MIFTS: 35

Mental Retardation (MR) malady

Neuronal diseases category

Summaries for Mental Retardation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intellectual disability (ID) or general learning disability is a generalized disorder appearing before... more...

MalaCards: Mental Retardation, also known as MR, is related to microcephaly and fragile x syndrome. An important gene associated with Mental Retardation is AFF2 (AF4/FMR2 family, member 2), and among its related pathways is Rho GTPase cycle. The drugs buspirone and buspirone hydrochloride have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and nervous system.

Aliases & Classifications for Mental Retardation

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20GeneTests, 44Novoseek, 60UMLS, 38NCBI Bookshelf
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mental retardation 20 44 60
mr 38


Related Diseases for Mental Retardation

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17GeneCards, 18GeneDecks
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Diseases related to Mental Retardation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1865)
idRelated DiseaseScoreTop Affiliating Genes
1microcephaly31.2ATRX, MECP2, PQBP1
2fragile x syndrome31.0MECP2, FXR2, AFF2
3epilepsy syndrome30.7OPHN1, ARX, ATRX, CLN8, MECP2
4intellectual disability30.5TSPAN7, OPHN1, PAK3, ACSL4, ZNF81, FXR2
5autistic disorder30.5MECP2, ARX, IL1RAPL1
6schizophrenia30.5MECP2, ACSL4
7rett syndrome30.5MECP2
8ohtahara syndrome29.7PCDH19
9image syndrome10.6
10neuronitis10.6
11muscular dystrophy10.6
12cleft palate10.6
13non-specific x-linked mental retardation10.6
14thalassemia10.6
15alpha thalassemia10.6
16brachydactyly10.6
17obesity10.5
18wagr syndrome10.5
19cataract10.5
20cerebritis10.5
21aniridia10.5
22coloboma10.5
23hypogonadism10.5
24retinitis10.5
25syndactyly10.4
26congenital muscular dystrophy10.4
27cleft lip10.4
28blepharophimosis10.4
29cerebellar ataxia10.4
30hypertrichosis10.4
31partington x-linked mental retardation syndrome10.4
32birk-barel syndrome10.4
33pervasive developmental disorder10.4
34ppm-x syndrome10.4
35wilson-turner x-linked mental retardation syndrome10.4
36coffin-lowry syndrome10.4
37hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.4
38dandy-walker malformation with mental retardation basal ganglia disease and seizures10.4
39epilepsy, female restricted, with mental retardation10.4
40lubs x-linked mental retardation syndrome10.4
41prieto x-linked mental retardation syndrome10.4
42mental retardation, with or without nystagmus10.4
43encephalitis10.4
44wernicke encephalopathy10.4
45x-linked ichthyosis10.3
46congenital heart defect10.3
47gingivitis10.3
48alopecia contractures dwarfism mental retardation10.3
49parkinsonism, early onset with mental retardation10.3
50deafness onychodystrophy osteodystrophy and mental retardation syndrome10.3

Graphical network of the top 20 diseases related to Mental Retardation:



Diseases related to mental retardation

Clinical Features for Mental Retardation

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Drugs & Therapeutics for Mental Retardation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mental Retardation

Drug clinical trials:

Search ClinicalTrials for Mental Retardation

Search NIH Clinical Center for Mental Retardation

Search CenterWatch for Mental Retardation

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mental Retardation

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20GeneTests
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Genetic tests related to Mental Retardation:

id Genetic test Affiliating Genes
1 Mental Retardation20

Anatomical Context for Mental Retardation

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Animal Models for Mental Retardation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mental Retardation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538612.4SMS, CC2D1A, OPHN1, ARX, ARHGEF6, MECP2
2MP:000363112.2MECP2, ARHGEF6, ARX, OPHN1, CC2D1A, ATRX
3MP:000538911.7MECP2, ATRX, CLN8, FXR2, ACSL4, SMS

Publications for Mental Retardation

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Genetic Variations for Mental Retardation

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Expression for genes affiliated with Mental Retardation

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mental Retardation

Search GEO for disease gene expression data for Mental Retardation.

Pathways for genes affiliated with Mental Retardation

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53Reactome
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Pathways related to Mental Retardation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.0GDI1, ARHGEF6, OPHN1

Compounds for genes affiliated with Mental Retardation

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GO Terms for genes affiliated with Mental Retardation

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16Gene Ontology
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Biological processes related to Mental Retardation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendrite developmentGO:01635810.8PAK3, MECP2
2lipid biosynthetic processGO:00861010.7ACSL4, CLN8
3regulation of small GTPase mediated signal transductionGO:05105610.7GDI1, ARHGEF6, OPHN1

Products for genes affiliated with Mental Retardation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mental Retardation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet