MCID: MNT063
MIFTS: 22

Mental Retardation, X-Linked malady

Neuronal diseases category

Summaries for Mental Retardation, X-Linked

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 X-linked intellectual disability (previously known as X-linked mental retardation) refers to forms of... more...

MalaCards: Mental Retardation, X-Linked is related to mental retardation, x-linked 17/31, microduplication and mental retardation x-linked with cerebellar hypoplasia and distinctive facial appearance. An important gene associated with Mental Retardation, X-Linked is ZNF81 (zinc finger protein 81), and among its related pathways is Rho GTPase cycle.

Description from OMIM:46 300495

Aliases & Classifications for Mental Retardation, X-Linked

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mental retardation, x-linked 46


Related Diseases for Mental Retardation, X-Linked

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Mental Retardation, X-Linked 3 family:

X-Linked Mental Retardation 21 Syp-Related X-Linked Mental Retardation
Znf711-Related X-Linked Mental Retardation Fgd1-Related X-Linked Mental Retardation
Kiaa2022-Related X-Linked Mental Retardation Znf674-Related X-Linked Mental Retardation
mental retardation, x-linked Mental Retardation, X-Linked 49
Mental Retardation, X-Linked 29 Mental Retardation, X-Linked 50
Mental Retardation, X-Linked 96 Mental Retardation, X-Linked 92
Mental Retardation, X-Linked 98 Mental Retardation, X-Linked 97
Mental Retardation, X-Linked 53 Mental Retardation, X-Linked 30/47
Mental Retardation, X-Linked 23 Mental Retardation, X-Linked 42

Diseases related to Mental Retardation, X-Linked via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation, x-linked 17/31, microduplication30.4HSD17B10, MRX31, MRX17
2mental retardation x-linked with cerebellar hypoplasia and distinctive facial appearance10.5
3ppm-x syndrome10.5
4x-linked disease10.5
5mental retardation, x-linked, syndromic, raymond type10.5
6mental retardation, x-linked, syndromic, nascimento type10.5
7mental retardation, x-linked, syndromic, turner type10.5
8snyder-robinson syndrome10.4
9christianson syndrome10.4
10fragile xe syndrome10.4
11mental retardation, x-linked, with growth hormone deficiency10.4
12mental retardation, x-linked, with short stature, small testes, muscle wasting, and tremor10.4
13mental retardation, x-linked, syndromic, martin-probst type10.4
14mental retardation, x-linked, syndromic 1510.4
15mental retardation, x-linked, with isolated growth hormone deficiency10.4
16alpha-thalassemia x-linked intellectual disability syndrome10.3
17x-linked creatine deficiency10.3
18dandy-walker malformation with mental retardation basal ganglia disease and seizures10.3
19hyde forster mccarthy berry syndrome10.3
20lujan fryns syndrome10.3
21miles-carpenter x-linked mental retardation syndrome10.3
22mental retardation x-linked borderline maoa metabolism anomaly10.3
23mental retardation x-linked dysmorphism10.3
24mental retardation x-linked, south african type10.3
25renpenning syndrome 110.3
26prieto x-linked mental retardation syndrome10.3
27partington x-linked mental retardation syndrome10.3
28wilson-turner x-linked mental retardation syndrome10.3
29x-linked mental retardation 2110.3
30mental retardation, x-linked 4910.3
31mental retardation, x-linked 2910.3
32mental retardation, x-linked 29 and others10.3
33mental retardation, x-linked syndromic, fried type10.3
34mental retardation, x-linked, syndromic 1710.3
35mental retardation, x-linked, syndromic, hedera type10.3
36mental retardation, x-linked 5010.3
37mental retardation, x-linked 9610.3
38mental retardation, x-linked 9210.3
39mental retardation, x-linked, syndromic 910.3
40mental retardation, x-linked 9810.3
41mental retardation, x-linked syndromic, abidi type10.3
42mental retardation, x-linked 9710.3
43mental retardation, x-linked, syndromic, chudley-schwartz type10.3
44mental retardation, x-linked 5310.3
45mental retardation, x-linked 30/4710.3
46mental retardation, x-linked 2310.3
47mental retardation, x-linked, with short stature10.3
48mental retardation, x-linked 4210.3
49mental retardation, x-linked syndromic, shashi type10.3
50mental retardation, x-linked, syndromic 3210.3

Graphical network of the top 20 diseases related to Mental Retardation, X-Linked:



Diseases related to mental retardation, x-linked

Clinical Features for Mental Retardation, X-Linked

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Sources:
46OMIM
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Clinical features from OMIM:

300495

Drugs & Therapeutics for Mental Retardation, X-Linked

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mental Retardation, X-Linked

Drug clinical trials:

Search ClinicalTrials for Mental Retardation, X-Linked

Search NIH Clinical Center for Mental Retardation, X-Linked

Search CenterWatch for Mental Retardation, X-Linked

Genetic Tests for Mental Retardation, X-Linked

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Anatomical Context for Mental Retardation, X-Linked

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Animal Models for Mental Retardation, X-Linked or affiliated genes

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Publications for Mental Retardation, X-Linked

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Genetic Variations for Mental Retardation, X-Linked

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Expression for genes affiliated with Mental Retardation, X-Linked

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mental Retardation, X-Linked

Search GEO for disease gene expression data for Mental Retardation, X-Linked.

Pathways for genes affiliated with Mental Retardation, X-Linked

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53Reactome
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Pathways related to Mental Retardation, X-Linked according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.5GDI1, ARHGEF6, OPHN1

Compounds for genes affiliated with Mental Retardation, X-Linked

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GO Terms for genes affiliated with Mental Retardation, X-Linked

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16Gene Ontology
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Biological processes related to Mental Retardation, X-Linked according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendrite developmentGO:01635810.5PAK3, MECP2
2regulation of small GTPase mediated signal transductionGO:05105610.2GDI1, ARHGEF6, OPHN1

Products for genes affiliated with Mental Retardation, X-Linked

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Mental Retardation, X-Linked

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet