Mental Retardation, X-linked malady

Wikipedia: X-linked mental retardation (also known as X-linked intellectual disability) refers to forms of mental...⁴⁴ more...

MalaCards: Mental Retardation, X-linked, also known as mental retardation, is related to mental retardation, x-linked, nonspecific and mental retardation x-linked with cerebellar hypoplasia and distinctive facial appearance. An important gene associated with Mental Retardation, X-linked is ZNF81 (zinc finger protein 81). The drugs buspirone hydrochloride and buspirone have been mentioned in the context of this disorder.

OMIM: 300495

mental retardation, x-linked 17 33 mental retardation 43

Disease types for mental retardation, x-linked family:

mental retardation, x-linked 14	x-linked mental retardation 17
x-linked mental retardation 19	x-linked mental retardation 30
x-linked mental retardation 41	x-linked mental retardation 45
x-linked mental retardation 46	x-linked mental retardation 54
x-linked mental retardation 58	x-linked mental retardation 59
x-linked mental retardation 63	x-linked mental retardation 72
x-linked mental retardation 88	x-linked mental retardation 89
x-linked mental retardation 9	x-linked mental retardation 90
x-linked mental retardation 91	x-linked mental retardation 93
x-linked mental retardation 94	x-linked mental retardation 95
mental retardation, x-linked-92	mental retardation, x-linked 84
mental retardation, x-linked-49	mental retardation, x-linked 20
mental retardation, x-linked, 1	mental retardation, x-linked 82
mental retardation, x-linked, 2	mental retardation, x-linked 81
mental retardation, x-linked 77	mental retardation, x-linked 78
mental retardation, x-linked 52	mental retardation, x-linked-53
mental retardation, x-linked 36/43/54	mental retardation, x-linked, 21/34

Diseases related to mental retardation, x-linked by text searches and GeneDecks gene sharing:

(show top 50)    (show all 708)

id	Related Disease	Score	Top Affiliating Genes
1	mental retardation, x-linked, nonspecific	35.9	GDI1, ACSL4, RPS6KA3, ARHGEF6, MRX42, MRX50
2	mental retardation x-linked with cerebellar hypoplasia and distinctive facial appearance	34.9	HN1, OPHN1
3	mental retardation x-linked syndromic 11	33.8	S11, MRXS11
4	x-linked syndromic mental retardation 10	33.5	HSD17B10, MRX17, MRX31
5	x-linked mental retardation with epilepsy	33.1	OPHN1, ARX, ATP6AP2
6	mental retardation, x-linked, 1	32.9	IQSEC2, MRX1
7	mental retardation, x-linked 17/31, microduplication	32.8	HSD17B10, MRX17, MRX31
8	mental retardation, x-linked 23, nonspecific	32.7	MRX23, MRX35, MRX27, MRX80
9	mental retardation syndrome	32.6	AFF2, ZDHHC9, UPF3B, KDM5C, UBE2A, ATRX
10	mental retardation, x-linked, fraxe type	32.0	FRAXE, AFF2
11	mental retardation, x-linked, syndromic 12	31.8	S12, MRXS12
12	mental retardation epilepsy	31.8	SLC9A6, OPHN1, SRPX2, ARX, ATP6AP2, ATRX
13	seizures	31.2	OPHN1, SYP, CUL4B, SRPX2, GRIA3, MECP2
14	x inactivation	31.0	SLC16A2, STS, HSD17B10, MECP2, IQSEC2, ATRX
15	spasticity	30.9	SLC16A2, OPHN1, TSPAN7, HSD17B10, MECP2, ARX
16	rett syndrome	30.9	GDI1, SOX3, GRIA3, MECP2, ATRX
17	mental retardation, x-linked syndromic	30.7	SLC9A6, PRS, WTS, CUL4B, HSD17B10, HUWE1
18	cerebellar hypoplasia	30.6	OPHN1, HN1, CASK, ARX, PAK3
19	fragile x syndrome	30.4	AFF2, DLG3, MECP2, FRAXE, FTSJ1
20	short stature	30.3	SOX3, STS, PQBP1, CUL4B, DLG3, FGD1
21	hypotonia	29.3	MRX15, MECP2, AP1S2, CASK, SMS, ACSL4
22	x-linked ichthyosis	29.1	STS, NLGN4X, VCX3B, VCX3A, VCX2
23	partington syndrome	28.5	RPS6KA3, DLG3, ARX
24	fg syndrome	28.4	RPS6KA3, DLG3, CASK
25	microcephaly	28.2	SLC9A6, SOX3, PQBP1, DLG3, CASK, MECP2
26	borjeson-forssman-lehmann syndrome	28.1	SOX3, DLG3, ARHGEF6
27	spastic diplegia	27.7	PQBP1, HSD17B10, ATRX
28	autism spectrum disorder	27.1	OPHN1, TSPAN7, ACSL4, NLGN4X, DLG3, IL1RAPL1
29	kallmann syndrome	25.9	STS, NLGN4X, VCX3B, VCX3A, VCX2
30	intellectual disability	20.5	STS, TSPAN7, AGTR2, ACSL4, NLGN4X, RPS6KA3
31	17-beta-hydroxysteroid dehydrogenase x deficiency	13.9	HSD17B10, MRX17, MRX31
32	growth mental deficiency syndrome of myhre	13.7	ACSL4, IL1RAPL1, MECP2, ARX, ARHGEF6, PAK3
33	autistic disorder	13.1	NLGN4X, DLG3, IL1RAPL1, MECP2, ARX, UPF3B
34	ocular albinism	11.8	VCX2, VCX3A, VCX3B, NLGN4X, STS
35	x-linked mental retardation 54	9.8
36	x-linked mental retardation 9	9.6
37	x-linked mental retardation 30	9.4
38	x-linked mental retardation 58	9.4
39	x-linked mental retardation 63	9.4
40	muscular dystrophy	9.3
41	wagr syndrome	9.2
42	renpenning syndrome 1	9.1
43	x-linked mental retardation 89	9.1
44	neuronitis	9.0
45	mental retardation x-linked syndromic 7	8.9
46	mental retardation, x-linked 14	8.9
47	x-linked mental retardation 17	8.9
48	x-linked mental retardation 45	8.9
49	x-linked mental retardation 46	8.9
50	x-linked mental retardation 59	8.9

Clinical features from OMIM: 300495

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 buspirone, buspirone hydrochloride

Articles related to mental retardation, x-linked:

id	Title	Authors	Year	Affiliating Genes
1	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis. (18076704)	Cuevas-Covarrubias S.A.... Gonzalez-Huerta L.M.	2008	STS, VCX3A, VCX2
2	Alpha thalassaemia-mental retardation, X linked. (16722615)	Gibbons R.	2006	ATRX

Genes related to mental retardation, x-linked according to GeneCards:

(show top 50)    (show all 118)

id	Symbol	Description	Score	GeneCards Section Context
1	ZNF81	zinc finger protein 81	11.1	Summaries, Aliases & Descriptions
2	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	11.1	Aliases & Descriptions, Summaries
3	ARX	aristaless related homeobox	11.1	Aliases & Descriptions
4	ACSL4	acyl-CoA synthetase long-chain family member 4	11.1	Aliases & Descriptions
5	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.1	Aliases & Descriptions
6	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	11.1	Aliases & Descriptions
7	MRXS11	mental retardation, X-linked, syndromic 11	11.1	Aliases & Descriptions
8	MRX17	mental retardation, X-linked 17	11.1	Aliases & Descriptions
9	MRX31	mental retardation, X-linked 31	11.1	Aliases & Descriptions
10	HSD17B10	hydroxysteroid (17-beta) dehydrogenase 10	11.1	Aliases & Descriptions
11	BRWD3	bromodomain and WD repeat domain containing 3	11.1	Summaries
12	MRXS12	Mental retardation, X-linked, syndromic 12	11.1	Aliases & Descriptions
13	MRX50	mental retardation, X-linked 50	11.1	Aliases & Descriptions
14	MRXS5	mental retardation, X-linked, syndromic 5	11.1	Aliases & Descriptions
15	MRXS7	mental retardation, X-linked, syndromic 7	11.1	Aliases & Descriptions
16	MRX42	mental retardation, X-linked 42	11.1	Aliases & Descriptions
17	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	11.1	Aliases & Descriptions
18	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	11.1	Aliases & Descriptions
19	MRX1	mental retardation, X-linked 1 (non-dysmorphic)	11.1	Aliases & Descriptions
20	MRX14	mental retardation, X-linked 14	11.1	Aliases & Descriptions
21	MRX27	mental retardation, X-linked 27	11.1	Aliases & Descriptions
22	MRX35	mental retardation, X-linked 35	11.1	Aliases & Descriptions
23	MRX20	mental retardation, X-linked 20	11.1	Aliases & Descriptions
24	MRX23	mental retardation, X-linked 23	11.1	Aliases & Descriptions
25	MRSS	Mental retardation, X-linked, with short stature	11.1	Aliases & Descriptions
26	MRX80	mental retardation, X-linked 80	11.1	Aliases & Descriptions
27	MRX53	mental retardation, X-linked 53	11.1	Aliases & Descriptions
28	MRX81	mental retardation, X-linked 81	11.1	Aliases & Descriptions
29	MRX82	mental retardation, X-linked 82	11.1	Aliases & Descriptions
30	MRX52	mental retardation, X-linked 52	11.1	Aliases & Descriptions
31	MRX77	mental retardation, X-linked 77	11.1	Aliases & Descriptions
32	MRX84	mental retardation, X-linked 84	11.1	Aliases & Descriptions
33	MRX49	mental retardation, X-linked 49	11.1	Aliases & Descriptions
34	MRX2	mental retardation, X-linked 2 (non-dysmorphic)	11.1	Aliases & Descriptions
35	MRX78	mental retardation, X-linked 78	11.1	Aliases & Descriptions
36	FTSJ1	FtsJ RNA methyltransferase homolog 1 (E. coli)	11.1	Aliases & Descriptions
37	MAGT1	magnesium transporter 1	11.1	Summaries
38	GDI1	GDP dissociation inhibitor 1	11.1	Aliases & Descriptions
39	OPHN1	oligophrenin 1	11.1	Aliases & Descriptions
40	MRXS17	Mental retardation, X-linked, syndromic 17	11.1	Aliases & Descriptions
41	MRXSCS	Mental retardation, X-linked, syndromic, Chudley-Schwartz type	11.1	Aliases & Descriptions
42	AP1S2	adaptor-related protein complex 1, sigma 2 subunit	11.1	Aliases & Descriptions
43	TSPAN7	tetraspanin 7	11.1	Aliases & Descriptions
44	MRX71	mental retardation, X-linked 71	11.1	Aliases & Descriptions
45	MRX62	mental retardation, X-linked 62	11.1	Aliases & Descriptions
46	MRX61	mental retardation, X-linked 61	11.1	Aliases & Descriptions
47	MRX74	mental retardation, X-linked 74	11.1	Aliases & Descriptions
48	MRX70	mental retardation, X-linked 70	11.1	Aliases & Descriptions
49	MRX69	mental retardation, X-linked 69	11.1	Aliases & Descriptions
50	MRX67	mental retardation, X-linked 67	11.1	Aliases & Descriptions

Biological processes related to mental retardation, x-linked according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	synapse organization	GO:050808	10.0	RAB39B, PAK3, NLGN4X