Mental Retardation, X-linked Syndromic malady

MalaCards: Mental Retardation, X-linked Syndromic, also known as mental retardation, is related to mental retardation syndrome and mental retardation, x-linked, syndromic 12. An important gene associated with Mental Retardation, X-linked Syndromic is MRXS12 (Mental retardation, X-linked, syndromic 12), and among its related pathways is Ubiquitin mediated proteolysis. The drugs buspirone hydrochloride and buspirone have been mentioned in the context of this disorder.

mental retardation, x-linked syndromic 33 mental retardation 43

Disease types for mental retardation, x-linked syndromic family:

mental retardation x-linked syndromic 11	mental retardation x-linked syndromic 7
mental retardation, x-linked, syndromic 14	x-linked syndromic mental retardation 10
mental retardation, x-linked, syndromic 12	mental retardation, x-linked syndromic 16
mental retardation, x-linked, syndromic 15 (cabezas type)

Diseases related to mental retardation, x-linked syndromic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 705)

id	Related Disease	Score	Top Affiliating Genes
1	mental retardation syndrome	32.9	KDM5C, FGD1, MECP2, HSD17B10
2	mental retardation, x-linked, syndromic 12	32.0	MRXS12, S12
3	x-linked syndromic mental retardation 10	31.2	HSD17B10, MRX17, MRX31
4	x inactivation	30.5	KDM5C, MECP2, HSD17B10
5	mental retardation, x-linked 17/31, microduplication	29.0	MRX31, MRX17, HSD17B10
6	seizures	28.9	CUL4B, MECP2, MRXS5, UBE2A, KDM5C
7	intellectual disability	25.5	SLC9A6, CUL4B, HSD17B10, MECP2, UBE2A, KDM5C
8	mental retardation, x-linked	22.0	MRX17, MRXSCS, MRXS5, MRXS7, MRXS12, MRX31
9	17-beta-hydroxysteroid dehydrogenase x deficiency	12.4	HSD17B10, MRX17, MRX31
10	microcephaly	9.4
11	muscular dystrophy	9.3
12	fragile x syndrome	9.2
13	mental retardation x-linked syndromic 7	9.2
14	wagr syndrome	9.2
15	neuronitis	9.0
16	mental retardation x-linked syndromic 11	8.8
17	mental retardation, x-linked, syndromic 14	8.8
18	mental retardation, x-linked, syndromic, nascimento type	8.8
19	mental retardation, x-linked, syndromic, turner type	8.8
20	ppm-x syndrome	8.8
21	congenital muscular dystrophy	8.8
22	mental retardation epilepsy	8.7
23	alpha-thalassemia/mental retardation syndrome	8.6
24	ataxia	8.6
25	mental retardation, x-linked, nonspecific	8.6
26	x-linked mental retardation 9	8.6
27	x-linked mental retardation with epilepsy	8.5
28	alpha thalassemia	8.4
29	short stature	8.4
30	thalassemia	8.4
31	x-linked mental retardation 58	8.4
32	x-linked mental retardation 63	8.4
33	x-linked mental retardation 89	8.4
34	mental retardation, x-linked, syndromic, raymond type	8.3
35	mental retardation, x-linked syndromic 16	8.3
36	mental retardation, x-linked, syndromic-5, with dandy-walker malformation, basal ganglia disease, and seizures	8.3
37	mental retardation, x-linked, syndromic-4, with congenital contractures and low fingertip arches	8.3
38	mental retardation, x-linked, syndromic, jarid1c-related	8.3
39	mental retardation, x-linked, syndromic 15 (cabezas type)	8.3
40	mental retardation, x-linked, syndromic 6, with gynecomastia and obesity	8.3
41	mental retardation, x-linked, syndromic-2, with dysmorphism and cerebral atrophy	8.3
42	mental retardation, x-linked, syndromic, martin-probst type	8.3
43	renpenning syndrome 1	8.3
44	christianson syndrome	8.3
45	lubs x-linked mental retardation syndrome	8.3
46	mental retardation x-linked with cerebellar hypoplasia and distinctive facial appearance	8.3
47	x-linked mental retardation 30	8.3
48	x-linked mental retardation 54	8.3
49	coffin-lowry syndrome	8.1
50	hypogonadism	8.1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 buspirone, buspirone hydrochloride

Genes related to mental retardation, x-linked syndromic according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	MRXS12	Mental retardation, X-linked, syndromic 12	11.1	Aliases & Descriptions
2	MRXS7	mental retardation, X-linked, syndromic 7	11.1	Aliases & Descriptions
3	MRXS5	mental retardation, X-linked, syndromic 5	11.1	Aliases & Descriptions
4	MRXS11	mental retardation, X-linked, syndromic 11	11.1	Aliases & Descriptions
5	HSD17B10	hydroxysteroid (17-beta) dehydrogenase 10	11.1	Aliases & Descriptions
6	MRXS17	Mental retardation, X-linked, syndromic 17	11.1	Aliases & Descriptions
7	MRXSCS	Mental retardation, X-linked, syndromic, Chudley-Schwartz type	11.1	Aliases & Descriptions
8	PRS	Prieto X-linked mental retardation syndrome	11.1
9	S12	surface antigen (X-linked) 3	11.1
10	WTS	Wilson-Turner X-linked mental retardation syndrome	11.1
11	MCS	Miles-Carpenter X-linked mental retardation syndrome	11.1
12	UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	11.1
13	SLC9A6	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	11.1
14	FGD1	FYVE, RhoGEF and PH domain containing 1	11.1
15	CUL4B	cullin 4B	11.1
16	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	11.1
17	MRX17	mental retardation, X-linked 17	11.1
18	MRX31	mental retardation, X-linked 31	11.1
19	UBE2A	ubiquitin-conjugating enzyme E2A	11.1
20	KDM5C	lysine (K)-specific demethylase 5C	11.1
21	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.1

Pathways related to mental retardation, x-linked syndromic according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Ubiquitin mediated proteolysis20	9.1	UBE2A, HUWE1, CUL4B