Aliases & Classifications for Mercury Poisoning

MalaCards integrated aliases for Mercury Poisoning:

Name: Mercury Poisoning 49 55
Mercury Intoxication 55
Mercury Toxicity 49
Mercurialism 55
Hydrargyria 55

Characteristics:

Orphanet epidemiological data:

55
mercury poisoning
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Mercury Poisoning

NIH Rare Diseases : 49 Mercury poisoning is a condition that occurs in people who are exposed to toxic levels of the element, mercury. There are three different forms of mercury that can cause health problems:Elemental mercury (also known as liquid mercury or quicksilver) can be found in glass thermometers, electrical switches, dental fillings and fluorescent light bulbs. This form of mercury is generally only harmful when small droplets become airborne and are inhaled. If this occurs, signs and symptoms of poisoning may include metallic taste, vomiting, difficulty breathing, coughing, and/or swollen, bleeding gums. In severe cases, long-term brain damage, permanent lung damage and even death may occur. Inorganic mercury is found in batteries, chemistry labs, and some disinfectants. This form of mercury is harmful when swallowed. Signs and symptoms of inorganic mercury poisoning vary based on the amount consumed, but may include burning in the stomach and throat; vomiting; and/or bloody diarrhea. Inorganic mercury can also affect the kidneys and brain if it enters the blood stream. Organic mercury can be found in fish. Some organisms convert fumes from burning coal into organic mercury. This form of mercury is harmful if inhaled, eaten, or placed on the skin for long periods of time. Long-term exposure to organic mercury may result in skin numbness or pain; tremor; inability to walk well; blindness; double vision; memory problems; seizures; or even death. Treatment is generally supportive and based on the signs and symptoms present in each person. Medications called chelators, which remove mercury and heavy metals from the body, are generally prescribed. Last updated: 2/5/2016

MalaCards based summary : Mercury Poisoning, also known as mercury intoxication, is related to infantile mercury poisoning and erythromelalgia, and has symptoms including hypertension, seizures and confusion. An important gene associated with Mercury Poisoning is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Immune response IFN alpha/beta signaling pathway. The drug Chelating Agents has been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and brain, and related phenotypes are Negative genetic interaction between PTTG1-/- and PTTG1+/+ and cellular

Wikipedia : 72 Mercury poisoning is a type of metal poisoning due to mercury exposure. Symptoms depend upon the type,... more...

Related Diseases for Mercury Poisoning

Diseases in the Mercury Poisoning family:

Infantile Mercury Poisoning

Diseases related to Mercury Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 infantile mercury poisoning 12.3
2 erythromelalgia 11.1
3 fetal methylmercury syndrome 10.4
4 omphalocele 10.2
5 nephrotic syndrome 10.1
6 peritonitis 10.1
7 hepatitis 10.1
8 pleural tuberculosis 10.0 B2M IL18
9 acute kidney failure 10.0 B2M IL18
10 penicillin allergy 10.0 IL13 IL18
11 latex allergy 10.0 IL13 IL18
12 eosinophilic gastritis 10.0 IL13 IL18
13 blood group, i system 10.0
14 neuronitis 10.0
15 hepatitis b 10.0
16 autoinflammation, lipodystrophy, and dermatosis syndrome 9.9 IL13 IL18
17 hemophagocytic lymphohistiocytosis 9.9 B2M IL18
18 visceral leishmaniasis 9.9 IL13 IL18
19 postaxial acrofacial dysostosis 9.9 PLAT THBD
20 eisenmenger syndrome 9.9 PLAT THBD
21 marantic endocarditis 9.9 PLAT THBD
22 dysfibrinogenemia 9.8 PLAT THBD
23 hepatic veno-occlusive disease 9.8 PLAT THBD
24 thrombophilia due to activated protein c resistance 9.8 PLAT THBD
25 thrombocytopenia 9.8
26 heavy metal poisoning 9.8
27 myoclonus 9.8
28 brucellosis 9.8
29 blood group--diego system 9.8
30 toxic shock syndrome 9.8
31 creutzfeldt-jakob disease 9.8
32 thrombocytopenia due to platelet alloimmunization 9.8
33 pheochromocytoma 9.8
34 vaginitis 9.8
35 autism 9.8
36 anuria 9.8
37 aging 9.8
38 hyperthyroidism 9.8
39 myocardial infarction 9.8
40 episodic pain syndrome, familial, 1 9.8
41 polyarteritis nodosa, childhood-onset 9.8
42 pemphigus 9.8
43 intracranial hypertension 9.8
44 pemphigus foliaceus 9.8
45 periostitis 9.8
46 renal tubular acidosis 9.8
47 thrombophilia due to thrombin defect 9.8 PLAT THBD
48 disseminated intravascular coagulation 9.8 PLAT THBD
49 antiphospholipid syndrome 9.8 PLAT THBD
50 allergic rhinitis 9.8 IL13 IL18

Graphical network of the top 20 diseases related to Mercury Poisoning:



Diseases related to Mercury Poisoning

Symptoms & Phenotypes for Mercury Poisoning

Human phenotypes related to Mercury Poisoning:

55 31 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 55 31 frequent (33%) Frequent (79-30%) HP:0000822
2 seizures 55 31 frequent (33%) Frequent (79-30%) HP:0001250
3 confusion 55 31 frequent (33%) Frequent (79-30%) HP:0001289
4 dystonia 55 31 frequent (33%) Frequent (79-30%) HP:0001332
5 tremor 55 31 frequent (33%) Frequent (79-30%) HP:0001337
6 tachycardia 55 31 frequent (33%) Frequent (79-30%) HP:0001649
7 acute kidney injury 55 31 frequent (33%) Frequent (79-30%) HP:0001919
8 nausea 55 31 frequent (33%) Frequent (79-30%) HP:0002018
9 anorexia 55 31 frequent (33%) Frequent (79-30%) HP:0002039
10 respiratory distress 55 31 frequent (33%) Frequent (79-30%) HP:0002098
11 abnormality of the cerebral white matter 55 31 frequent (33%) Frequent (79-30%) HP:0002500
12 episodic vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002572
13 episodic abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002574
14 hypotension 55 31 frequent (33%) Frequent (79-30%) HP:0002615
15 respiratory failure 55 31 frequent (33%) Frequent (79-30%) HP:0002878
16 hypokalemia 55 31 frequent (33%) Frequent (79-30%) HP:0002900
17 generalized muscle weakness 55 31 frequent (33%) Frequent (79-30%) HP:0003324
18 interstitial pneumonitis 55 31 frequent (33%) Frequent (79-30%) HP:0006515
19 loss of consciousness 55 31 frequent (33%) Frequent (79-30%) HP:0007185
20 insomnia 55 31 frequent (33%) Frequent (79-30%) HP:0100785
21 dyspnea 55 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mercury Poisoning according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.8 B2M IL13 THBD

MGI Mouse Phenotypes related to Mercury Poisoning:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 B2M IL13 IL18 PLAT THBD
2 digestive/alimentary MP:0005381 9.83 B2M IL13 IL18 PLAT THBD
3 growth/size/body region MP:0005378 9.8 B2M IL13 IL18 PLAT THBD
4 hematopoietic system MP:0005397 9.77 B2M IL13 IL18 PLAT THBD
5 homeostasis/metabolism MP:0005376 9.72 THBD B2M IL13 IL18 PLAT
6 immune system MP:0005387 9.65 B2M IL13 IL18 PLAT THBD
7 integument MP:0010771 9.55 B2M IL13 IL18 PLAT THBD
8 mortality/aging MP:0010768 9.35 B2M IL13 IL18 PLAT THBD
9 reproductive system MP:0005389 8.92 B2M IL13 PLAT THBD

Drugs & Therapeutics for Mercury Poisoning

Drugs for Mercury Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chelating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication Completed NCT02486289 Phase 2 Emeramide;Placebo
2 Environmental Contaminants and Infant Development Completed NCT00013858

Search NIH Clinical Center for Mercury Poisoning

Genetic Tests for Mercury Poisoning

Anatomical Context for Mercury Poisoning

MalaCards organs/tissues related to Mercury Poisoning:

38
Kidney, Skin, Brain, Lung, Liver, Skeletal Muscle, Cortex

Publications for Mercury Poisoning

Articles related to Mercury Poisoning:

(show top 50) (show all 346)
# Title Authors Year
1
Mercury poisoning in a fisherman working on a pelagic fishing vessel due to excessive tuna consumption. ( 29093364 )
2018
2
Mercury Poisoning in a Toddler from Home Contamination due to Skin-Lightening Cream. ( 29395180 )
2018
3
Mercury poisoning through intravenous administration: Two case reports with literature review. ( 29145289 )
2017
4
Mercury poisoning in the Grassy Narrows First Nation: history not completed. ( 28584045 )
2017
5
An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function. ( 29033890 )
2017
6
MiR-92a and miR-486 are potential diagnostic biomarkers for mercury poisoning and jointly sustain NF-I_B activity in mercury toxicity. ( 29167424 )
2017
7
The interwoven history of mercury poisoning in Ontario and Japan. ( 28385869 )
2017
8
Mercury Poisoning at a Home Day Care Center - Hillsborough County, Florida, 2015. ( 28472024 )
2017
9
Assessment and management of elemental mercury poisoning-a case report. ( 28174636 )
2017
10
Cases of acute mercury poisoning by mercury vapor exposure during the demolition of a fluorescent lamp factory. ( 28649389 )
2017
11
Occupational Metallic Mercury Poisoning in Gilders. ( 27112720 )
2016
12
Mercury Poisoning in Operational Settings among Gilders. ( 27651086 )
2016
13
The interwoven history of mercury poisoning in Ontario and Japan. ( 27920011 )
2016
14
Saint Ioannis Lampadistis, the first possible case of blindness due to organic mercury poisoning in history. ( 27686425 )
2016
15
Acute Mercury Poisoning in a Group of School Children. ( 27977534 )
2016
16
Mercury poisoning caused by Chinese folk prescription (CFP): A case report and analysis of both CFP and quackery. ( 27858849 )
2016
17
Acute mercury poisoning from occult ritual use. ( 28913479 )
2016
18
Notes from the Field: Acute Mercury Poisoning After Home Gold and Silver Smelting--Iowa, 2014. ( 26678598 )
2015
19
Mercury poisoning presenting as sporadic creutzfeldt-jakob disease: a case report. ( 25775335 )
2015
20
Mercury poisoning in two 13-year-old twin sisters. ( 26109979 )
2015
21
Mercury poisoning: a case of a complex neuropsychiatric illness. ( 25756767 )
2014
22
Subacute motor neuron hyperexcitability with mercury poisoning: a case series and literature review. ( 25227723 )
2014
23
Mercury Poisoning as a Cause of Intracranial Hypertension. ( 25122110 )
2014
24
Acute mercury poisoning presenting as fever of unknown origin in an adult woman: a case report. ( 25084829 )
2014
25
Mercury poisoning dentistry: high-level indoor air mercury contamination at selected dental sites. ( 24552960 )
2014
26
Current approaches of the management of mercury poisoning: need of the hour. ( 24888360 )
2014
27
Public health department response to mercury poisoning: the importance of biomarkers and risks and benefits analysis for chelation therapy. ( 24197663 )
2013
28
Mercury poisoning from home gold amalgam extraction. ( 23879513 )
2013
29
Ophthalmic findings in acute mercury poisoning in adults: A case series study. ( 23524881 )
2013
30
The role of chelation in the treatment of arsenic and mercury poisoning. ( 24178900 )
2013
31
Acute mercury poisoning among children in two provinces of Turkey. ( 23411638 )
2013
32
Assessment and management of mercury poisoning with an unusual abdominal x-ray! ( 23087291 )
2012
33
Mercury poisoning: a diagnostic challenge. ( 23128656 )
2012
34
Chronic methyl mercury poisoning may trigger endemic pemphigus foliaceus "fogo selvagem". ( 22000710 )
2012
35
Elemental mercury poisoning presenting as hypertension in a young child. ( 22863825 )
2012
36
Not all that glitters: mercury poisoning in Colombia. ( 22509527 )
2012
37
Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran. ( 21803782 )
2012
38
Re: Care of patients who are worried about mercury poisoning from dental fillings. ( 21737774 )
2011
39
Inorganic mercury poisoning associated with skin-lightening cosmetic products. ( 22070559 )
2011
40
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. ( 20810785 )
2011
41
Pediatric mercury poisoning, brain MRI, and white matter hyperintensities. ( 21340488 )
2011
42
Elemental mercury poisoning caused by subcutaneous and intravenous injection: An unusual self-injury. ( 20607031 )
2010
43
Acute mercury poisoning: a case report. ( 20302609 )
2010
44
Fatal mercury poisoning and chelating agents. ( 20537473 )
2010
45
Care of patients who are worried about mercury poisoning from dental fillings. ( 21057078 )
2010
46
Images in radiology. An element of surprise. Mercury poisoning. ( 20920692 )
2010
47
Mercury poisoning in a free-living northern river otter (Lontra canadensis). ( 20688719 )
2010
48
Chronic mercury poisoning: Report of two siblings. ( 20808663 )
2010
49
Fish faddism causing low-level mercury poisoning in the Caribbean: two case reports. ( 20126317 )
2009
50
Mercury poisoning in a German shepherd dog. ( 19820261 )
2009

Variations for Mercury Poisoning

Expression for Mercury Poisoning

Search GEO for disease gene expression data for Mercury Poisoning.

Pathways for Mercury Poisoning

GO Terms for Mercury Poisoning

Cellular components related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 B2M PLAT THBD
2 extracellular space GO:0005615 9.02 B2M IL13 IL18 PLAT THBD

Biological processes related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 B2M IL13 IL18
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 IL13 IL18
3 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 IL13 IL18

Sources for Mercury Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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