Aliases & Classifications for Mercury Poisoning

Aliases & Descriptions for Mercury Poisoning:

Name: Mercury Poisoning 50 56
Mercury Intoxication 56
Mercury Toxicity 50
Mercurialism 56
Hydrargyria 56

Characteristics:

Orphanet epidemiological data:

56
mercury poisoning
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Orphanet 56 ORPHA330021
ICD10 via Orphanet 34 T56.1

Summaries for Mercury Poisoning

NIH Rare Diseases : 50 mercury poisoning is a condition that occurs in people who are exposed to toxic levels of the element, mercury. there are three different forms of mercury that can cause health problems:elemental mercury (also known as liquid mercury or quicksilver) can be found in glass thermometers, electrical switches, dental fillings and fluorescent light bulbs. this form of mercury is generally only harmful when small droplets become airborne and are inhaled. if this occurs, signs and symptoms of poisoning may include metallic taste, vomiting, difficulty breathing, coughing, and/or swollen, bleeding gums. in severe cases, long-term brain damage, permanent lung damage and even death may occur. inorganic mercury is found in batteries, chemistry labs, and some disinfectants. this form of mercury is harmful when swallowed. signs and symptoms of inorganic mercury poisoning vary based on the amount consumed, but may include burning in the stomach and throat; vomiting; and/or bloody diarrhea. inorganic mercury can also affect the kidneys and brain if it enters the blood stream. organic mercury can be found in fish. some organisms convert fumes from burning coal into organic mercury. this form of mercury is harmful if inhaled, eaten, or placed on the skin for long periods of time. long-term exposure to organic mercury may result in skin numbness or pain; tremor; inability to walk well; blindness; double vision; memory problems; seizures; or even death. treatment is generally supportive and based on the signs and symptoms present in each person. medications called chelators, which remove mercury and heavy metals from the body, are generally prescribed. last updated: 2/5/2016

MalaCards based summary : Mercury Poisoning, also known as mercury intoxication, is related to infantile mercury poisoning and fetal methyl mercury syndrome, and has symptoms including seizures, tremor and nausea. An important gene associated with Mercury Poisoning is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Immune response IFN alpha/beta signaling pathway. The drugs Tolvaptan and Succimer have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and brain, and related phenotypes are Negative genetic interaction between PTTG1-/- and PTTG1+/+ and cellular

Wikipedia : 71 Mercury poisoning is a type of metal poisoning, due to mercury exposure. Symptoms depend upon the type,... more...

Related Diseases for Mercury Poisoning

Diseases in the Mercury Poisoning family:

Infantile Mercury Poisoning

Diseases related to Mercury Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 infantile mercury poisoning 12.0
2 fetal methyl mercury syndrome 12.0
3 erythromelalgia 11.0
4 omphalocele 10.1
5 glucose intolerance 10.1 B2M IL18
6 idiopathic juvenile osteoporosis 10.1 B2M IL18
7 luminal breast carcinoma 10.1 IL13 IL18
8 lymphocytic gastritis 10.0 IL13 IL18
9 acute lymphoblastic leukemia, childhood 10.0 B2M IL18
10 peritonitis 10.0
11 hepatitis 10.0
12 nephrotic syndrome 10.0
13 immunodeficiency 32a, mycobacteriosis, autosomal dominant 10.0 PLAT THBD
14 enamel hypoplasia cataract hydrocephaly 10.0 PLAT THBD
15 ductal carcinoma in situ 10.0 PLAT THBD
16 eagle syndrome 10.0 PLAT THBD
17 bare lymphocyte syndrome, type i 10.0 IL13 IL18
18 septic myocarditis 10.0 PLAT THBD
19 zika virus congenital syndrome 9.9 PLAT THBD
20 pregnancy loss, recurrent 1 9.9 PLAT THBD
21 hereditary ataxia 9.9 B2M IL18
22 brill-zinsser disease 9.9 PLAT THBD
23 immunodeficiency, common variable, 6 9.9 PLAT THBD
24 sertoli-leydig cell tumor 9.9 PLAT THBD
25 mental retardation, autosomal dominant 18 9.9 IL13 IL18
26 congenital chloride diarrhea 9.9 PLAT THBD
27 bone development disease 9.9 PLAT THBD
28 hepatitis b 9.9
29 neuronitis 9.9
30 gangliosidosis gm2 9.9 IL13 IL18
31 glucocorticoid resistance 9.8 IL13 IL18
32 pheochromocytoma 9.7
33 myocardial infarction 9.7
34 pemphigus 9.7
35 creutzfeldt-jakob disease 9.7
36 intracranial hypertension 9.7
37 periostitis 9.7
38 pemphigus foliaceus 9.7
39 birth defects 9.7
40 renal tubular acidosis 9.7
41 thrombocytopenia 9.7
42 heavy metal poisoning 9.7
43 myoclonus 9.7
44 brucellosis 9.7
45 toxic shock syndrome 9.7
46 vaginitis 9.7
47 anuria 9.7
48 hyperthyroidism 9.7
49 immunodeficiency due to defect in mapbp-interacting protein 9.7 IL13 IL18 THBD
50 metaphyseal chondrodysplasia with cone-shaped epiphyses, normal hair, and normal hands 9.4 B2M IL13 IL18 PLAT THBD

Graphical network of the top 20 diseases related to Mercury Poisoning:



Diseases related to Mercury Poisoning

Symptoms & Phenotypes for Mercury Poisoning

Human phenotypes related to Mercury Poisoning:

56 32 (show all 21)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 56 32 Frequent (79-30%) HP:0001250
2 tremor 56 32 Frequent (79-30%) HP:0001337
3 nausea 56 32 Frequent (79-30%) HP:0002018
4 respiratory distress 56 32 Frequent (79-30%) HP:0002098
5 dystonia 56 32 Frequent (79-30%) HP:0001332
6 generalized muscle weakness 56 32 Frequent (79-30%) HP:0003324
7 hypertension 56 32 Frequent (79-30%) HP:0000822
8 hypotension 56 32 Frequent (79-30%) HP:0002615
9 hypokalemia 56 32 Frequent (79-30%) HP:0002900
10 anorexia 56 32 Frequent (79-30%) HP:0002039
11 respiratory failure 56 32 Frequent (79-30%) HP:0002878
12 episodic abdominal pain 56 32 Frequent (79-30%) HP:0002574
13 insomnia 56 32 Frequent (79-30%) HP:0100785
14 acute kidney injury 56 32 Frequent (79-30%) HP:0001919
15 tachycardia 56 32 Frequent (79-30%) HP:0001649
16 confusion 56 32 Frequent (79-30%) HP:0001289
17 loss of consciousness 56 32 Frequent (79-30%) HP:0007185
18 interstitial pneumonitis 56 32 Frequent (79-30%) HP:0006515
19 abnormality of the cerebral white matter 56 32 Frequent (79-30%) HP:0002500
20 episodic vomiting 56 32 Frequent (79-30%) HP:0002572
21 dyspnea 56 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mercury Poisoning according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.8 B2M IL13 THBD

MGI Mouse Phenotypes related to Mercury Poisoning:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 B2M IL13 IL18 PLAT THBD
2 digestive/alimentary MP:0005381 9.83 B2M IL13 IL18 PLAT THBD
3 growth/size/body region MP:0005378 9.8 B2M IL13 IL18 PLAT THBD
4 hematopoietic system MP:0005397 9.77 B2M IL13 IL18 PLAT THBD
5 homeostasis/metabolism MP:0005376 9.72 B2M IL13 IL18 PLAT THBD
6 immune system MP:0005387 9.65 B2M IL13 IL18 PLAT THBD
7 integument MP:0010771 9.46 B2M IL13 IL18 THBD
8 mortality/aging MP:0010768 9.35 B2M IL13 IL18 PLAT THBD
9 reproductive system MP:0005389 8.92 B2M IL13 PLAT THBD

Drugs & Therapeutics for Mercury Poisoning

Drugs for Mercury Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 3 150683-30-0 216237
2
Succimer Approved Phase 3,Phase 1,Phase 2 304-55-2 9354
3 Chelating Agents Phase 3,Phase 2,Phase 1
4 Natriuretic Agents Phase 3
5 Hormones Phase 3
6 Vasopressins Phase 3
7 Protective Agents Phase 3,Phase 1,Phase 2
8 Antidotes Phase 3,Phase 1,Phase 2
9 Arginine Vasopressin Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment of Lead-Exposed Children Trial Completed NCT00342849 Phase 3
2 “SALT Trial” Study of Ascending Levels of Tolvaptan in Hyponatremia Completed NCT00072683 Phase 3
3 Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication Completed NCT02486289 Phase 2
4 Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2
5 Environmental Contaminants and Infant Development Completed NCT00013858

Search NIH Clinical Center for Mercury Poisoning

Genetic Tests for Mercury Poisoning

Anatomical Context for Mercury Poisoning

MalaCards organs/tissues related to Mercury Poisoning:

39
Kidney, Skin, Brain, Lung, Liver, Skeletal Muscle, Cortex

Publications for Mercury Poisoning

Articles related to Mercury Poisoning:

(show top 50) (show all 335)
id Title Authors Year
1
Mercury poisoning caused by Chinese folk prescription (CFP): A case report and analysis of both CFP and quackery. ( 27858849 )
2016
2
The interwoven history of mercury poisoning in Ontario and Japan. ( 27920011 )
2016
3
Mercury Poisoning in Operational Settings among Gilders. ( 27651086 )
2016
4
Acute Mercury Poisoning in a Group of School Children. ( 27977534 )
2016
5
Saint Ioannis Lampadistis, the first possible case of blindness due to organic mercury poisoning in history. ( 27686425 )
2016
6
Occupational Metallic Mercury Poisoning in Gilders. ( 27112720 )
2016
7
Mercury poisoning in two 13-year-old twin sisters. ( 26109979 )
2015
8
Mercury poisoning presenting as sporadic creutzfeldt-jakob disease: a case report. ( 25775335 )
2015
9
Notes from the Field: Acute Mercury Poisoning After Home Gold and Silver Smelting--Iowa, 2014. ( 26678598 )
2015
10
Acute mercury poisoning presenting as fever of unknown origin in an adult woman: a case report. ( 25084829 )
2014
11
Mercury poisoning dentistry: high-level indoor air mercury contamination at selected dental sites. ( 24552960 )
2014
12
Current approaches of the management of mercury poisoning: need of the hour. ( 24888360 )
2014
13
Mercury Poisoning as a Cause of Intracranial Hypertension. ( 25122110 )
2014
14
Subacute motor neuron hyperexcitability with mercury poisoning: a case series and literature review. ( 25227723 )
2014
15
Mercury poisoning: a case of a complex neuropsychiatric illness. ( 25756767 )
2014
16
Ophthalmic findings in acute mercury poisoning in adults: A case series study. ( 23524881 )
2013
17
The role of chelation in the treatment of arsenic and mercury poisoning. ( 24178900 )
2013
18
Acute mercury poisoning among children in two provinces of Turkey. ( 23411638 )
2013
19
Mercury poisoning from home gold amalgam extraction. ( 23879513 )
2013
20
Public health department response to mercury poisoning: the importance of biomarkers and risks and benefits analysis for chelation therapy. ( 24197663 )
2013
21
Not all that glitters: mercury poisoning in Colombia. ( 22509527 )
2012
22
Chronic methyl mercury poisoning may trigger endemic pemphigus foliaceus "fogo selvagem". ( 22000710 )
2012
23
Mercury poisoning: a diagnostic challenge. ( 23128656 )
2012
24
Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran. ( 21803782 )
2012
25
Elemental mercury poisoning presenting as hypertension in a young child. ( 22863825 )
2012
26
Assessment and management of mercury poisoning with an unusual abdominal x-ray! ( 23087291 )
2012
27
Inorganic mercury poisoning associated with skin-lightening cosmetic products. ( 22070559 )
2011
28
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. ( 20810785 )
2011
29
Re: Care of patients who are worried about mercury poisoning from dental fillings. ( 21737774 )
2011
30
Pediatric mercury poisoning, brain MRI, and white matter hyperintensities. ( 21340488 )
2011
31
Acute mercury poisoning: a case report. ( 20302609 )
2010
32
Chronic mercury poisoning: Report of two siblings. ( 20808663 )
2010
33
Care of patients who are worried about mercury poisoning from dental fillings. ( 21057078 )
2010
34
Elemental mercury poisoning caused by subcutaneous and intravenous injection: An unusual self-injury. ( 20607031 )
2010
35
Images in radiology. An element of surprise. Mercury poisoning. ( 20920692 )
2010
36
Fatal mercury poisoning and chelating agents. ( 20537473 )
2010
37
Mercury poisoning in a free-living northern river otter (Lontra canadensis). ( 20688719 )
2010
38
Mercury poisoning: a rare but treatable cause of failure to thrive and developmental regression in an infant. ( 19197099 )
2009
39
Mercury poisoning in a German shepherd dog. ( 19820261 )
2009
40
Fish faddism causing low-level mercury poisoning in the Caribbean: two case reports. ( 20126317 )
2009
41
Elemental mercury poisoning probably causes cortical myoclonus. ( 17708573 )
2007
42
Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning. ( 17681548 )
2007
43
A Child with elemental mercury poisoning and unusual brain MRI findings. ( 16496500 )
2006
44
I love canned tuna, but I've heard that eating too much increases your risk of mercury poisoning. Is this true? ( 16489293 )
2006
45
Ethyl mercury poisoning during a protein A immunoadsorption treatment. ( 16431248 )
2006
46
Diet-related mercury poisoning resulting in visual loss. ( 17057175 )
2006
47
Mercury exposure: evaluation and intervention the inappropriate use of chelating agents in the diagnosis and treatment of putative mercury poisoning. ( 16009427 )
2005
48
[Effects of chronic mercury poisoning on blood coagulation and fibrinolysis systems]. ( 16405768 )
2005
49
Wide use of merthiolate may cause mercury poisoning in Mexico. ( 15669718 )
2004
50
Metallic and inorganic mercury poisoning. ( 12733281 )
2003

Variations for Mercury Poisoning

Expression for Mercury Poisoning

Search GEO for disease gene expression data for Mercury Poisoning.

Pathways for Mercury Poisoning

GO Terms for Mercury Poisoning

Cellular components related to Mercury Poisoning according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 B2M PLAT THBD
2 extracellular space GO:0005615 9.02 B2M IL13 IL18 PLAT THBD

Biological processes related to Mercury Poisoning according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.13 B2M IL13 IL18
2 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 IL13 IL18

Molecular functions related to Mercury Poisoning according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glycoprotein binding GO:0001948 8.62 B2M PLAT

Sources for Mercury Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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