MCID: MRK001
MIFTS: 54

Merkel Cell Carcinoma malady

Cancer diseases category

Summaries for Merkel Cell Carcinoma

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Merkel cell carcinoma is a rare type of skin cancer that appears as a painless, hardened, red to purplish bump.  it occurs primarily in sun-exposed skin of the head and neck, though it can also occur on the skin of the arms, legs, and trunk.  it is considered fast-growing (aggressive), meaning that it can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body.  merkel cell carcinoma is diagnosed by biopsy, when some of the tissue is removed and examined under a microscope.  in 2007, approximately 1500 people in the united states were diagnosed with this type of cancer.  treatment depends on the size of the cancer and the extent to which it has spread as determined by imaging studies. last updated: 5/28/2011

MalaCards: Merkel Cell Carcinoma, also known as trabecular adenocarcinoma, is related to neuroendocrine carcinoma and squamous cell carcinoma. An important gene associated with Merkel Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Neuroscience and Transcription factors in neurogenesis. The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and thyroid, and related mouse phenotypes are no phenotypic analysis and cellular.

Wikipedia:63 Merkel cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by a... more...

Aliases & Classifications for Merkel Cell Carcinoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

merkel cell carcinoma 8 42 10 60
trabecular adenocarcinoma 8 60
carcinoma, merkel cell 42
carcinoma merkel cell 44
trabecular carcinoma 8
merkel cell cancer 42
merkle tumors 42


External Ids:

Disease Ontology8 DOID:3965
SNOMED-CT56 29792007
NCIt39 C4068

Related Diseases for Merkel Cell Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Merkel Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.2S100B, NKX2-1, SYP, KIT, KRT20, ASCL1
2squamous cell carcinoma30.9PIP, NKX2-1, SYP, CD151, EPCAM, KRT20
3large cell carcinoma30.8KRT20, SYP, NKX2-1
4melanoma30.7S100B, NKX2-1, POU3F2, CD151, EPCAM, KIT
5lung small cell carcinoma30.6NKX2-1, SYP, CD99, EPCAM, KIT, KRT20
6sarcoma30.6S100B, CD99, B3GAT1, KIT
7retinoblastoma30.6SYP, EPCAM
8neuroendocrine tumor30.4NKX2-1, SYP, KRT20, ASCL1
9paraganglioma30.2S100B, SYP, KIT
10neuroblastoma30.2SYP
11adenocarcinoma30.2PIP, NKX2-1, SYP, EPCAM, KRT20, ASCL1
12rhabdomyosarcoma30.2CD99, S100B
13pheochromocytoma30.2ASCL1, SYP
14kidney cancer30.2NKX2-1, EPCAM, KIT, KRT20
15small cell carcinoma10.7
16chronic lymphocytic leukemia10.5
17leukemia10.5
18basal cell carcinoma10.5
19in situ carcinoma10.5
20thyroiditis10.5
21renal cell carcinoma10.5
22bone carcinoma10.4
23pancreatitis10.4
24transitional cell carcinoma10.4
25dermatofibrosarcoma10.3
26lymphoepithelioma-like carcinoma10.3
27kaposi's sarcoma10.3
28adrenal carcinoma10.3
29epidermodysplasia verruciformis10.3
30myeloma10.3
31skin disease10.3
32merkel cell carcinoma, somatic10.3
33cutaneous neuroendocrine carcinoma10.3
34cardiac tamponade10.1
35pancreatic endocrine carcinoma10.1
36actinic keratosis10.1
37somatostatinoma10.1
38psoriatic arthritis10.1
39pancytopenia10.1
40penile neoplasm10.1
41adult xanthogranuloma10.1
42pityriasis rubra pilaris10.1
43skin glomus tumor10.1
44tonsillitis10.1
45differentiating neuroblastoma10.1
46duodenitis10.1
47sporotrichosis10.1
48insulinoma10.1
49retroperitoneum carcinoma10.1
50arthritis10.1

Graphical network of the top 20 diseases related to Merkel Cell Carcinoma:



Diseases related to merkel cell carcinoma

Clinical Features for Merkel Cell Carcinoma

About this section

Drugs & Therapeutics for Merkel Cell Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Merkel Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Merkel Cell Carcinoma

Search NIH Clinical Center for Merkel Cell Carcinoma

Search CenterWatch for Merkel Cell Carcinoma

Genetic Tests for Merkel Cell Carcinoma

About this section

Anatomical Context for Merkel Cell Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Merkel Cell Carcinoma:

32
Skin, Lymph node, Thyroid, Pancreas, Lung, Kidney, Bone, B cells, T cells, Breast, Bone marrow, Heart, Endothelial, Tonsil, Adrenal gland, Salivary gland, Colon, Pituitary

Animal Models for Merkel Cell Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Merkel Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.5ASCL1, KIT, EPCAM, SYP, NKX2-1, ATOH1
2MP:000538410.4TSPAN32, ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2
3MP:000363110.4POU4F3, SYP, NKX2-1, ATOH1, POU3F2, AXIN2
4MP:000287310.3S100B, ATOH1, SYP, POU4F3, DNTT, AXIN2
5MP:000537910.1ATOH1, NKX2-1, POU3F2, AXIN2, EPCAM, KIT

Publications for Merkel Cell Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Merkel Cell Carcinoma:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
Outcome of patients with microscopic and macroscopic metastatic nodal merkel cell carcinoma: an Australian experience. (24320201)
2014
2
Merkel cell polyomavirus and extrapulmonary small cell carcinoma. (24137462)
2013
3
Primary cutaneous neuroendocrine carcinoma, Merkel cell carcinoma. Case series 1991-2012. (24094946)
2013
4
Expression of activation-induced cytidine deaminase in Merkel cell carcinoma with lymph-node metastasis. (24001680)
2013
5
Expression of anaplastic lymphoma kinase in Merkel cell carcinomas. (23574788)
2013
6
PD-L1 expression in the Merkel cell carcinoma microenvironment: Association with inflammation, Merkel cell polyomavirus and overall survival. (24416729)
2013
7
Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region. (24294181)
2013
8
Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma. (23907948)
2013
9
Effect of radiation therapy on survival in patients with resected Merkel cell carcinoma: a propensity score surveillance, epidemiology, and end results database analysis. (23864085)
2013
10
Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma. (23353989)
2013
11
Orbital metastasis secondary to merkel cell carcinoma: case report and literature review. (23662641)
2013
12
Merkel cell carcinoma: a systematic review of ENT presentations. (23192664)
2013
13
Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma. (24034376)
2013
14
Merkel cell carcinoma of left groin: a case report and literature review. (23762689)
2013
15
Merkel cell carcinoma: a retrospective study on 48 cases and review of literature. (23024654)
2012
16
Primary tumor thickness as a prognostic factor in Merkel cell carcinoma: the next big thing? (22825775)
2012
17
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of merkel cell carcinoma metastatic to the pancreas. (22730170)
2012
18
Cutaneous Merkel cell carcinoma. (21696854)
2012
19
The role of free tissue transfer in merkel cell carcinoma of the head and neck. (22934186)
2012
20
Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes. (22415238)
2012
21
Sentinel lymph node biopsy in patients with Merkel cell carcinoma: an emerging role and the Westmead hospital experience. (22309327)
2012
22
Radiotherapy is associated with significant improvement in local and regional control in Merkel cell carcinoma. (23075308)
2012
23
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. (21413015)
2012
24
Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas. (21765392)
2011
25
Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States. (21514002)
2011
26
Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients. (21385344)
2011
27
Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin. (20696637)
2010
28
Clinical recognition, diagnosis, and staging of merkel cell carcinoma, and the role of the multidisciplinary management team. (20371073)
2010
29
Merkel cell carcinoma of the eyelid: a report of 2 cases. (20130724)
2010
30
Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors. (19615033)
2010
31
Merkel cell carcinoma: case report. (21305745)
2010
32
PET/CT imaging of metastatic Merkel cell carcinoma to the adrenal glands. (22789832)
2010
33
Merkel cell carcinoma of the face: follow-up report of 10 cases in Germany. (19683371)
2010
34
Multimodality management for 145 cases of Merkel cell carcinoma. (19949898)
2010
35
Patients with Merkel cell carcinoma tumors < or = 1.0 cm in diameter are unlikely to harbor regional lymph node metastasis. (19581538)
2009
36
Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinoma. (19013049)
2009
37
Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma. (19564526)
2009
38
Merkel cell carcinoma: a review of current advances. (19401065)
2009
39
Giant Merkel cell carcinoma of the left arm. Case report. (20476686)
2009
40
Frequent occurrence of RASSF1A promoter hypermethylation and Merkel cell polyomavirus in Merkel cell carcinoma. (19326371)
2009
41
A violaceous nodule on the knee. Merkel cell carcinoma (MCC). (19528432)
2009
42
Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. (18425079)
2008
43
Collision tumor composed of Merkel cell carcinoma and lentigo maligna melanoma. (18190446)
2008
44
Merkel cell carcinoma: an unusual indication for isolated limb perfusion. (18718190)
2008
45
Increased warfarin sensitivity complicated by retroperitoneal haemorrhage in a patient with merkel cell carcinoma. (23340927)
2003
46
Primary undifferentiated small cell carcinoma (Merkel cell carcinoma) in a patient after heart transplantation--case report. (12476622)
2002
47
Merkel cell carcinoma, Kaposi's sarcoma, basal cell carcinoma and keratoacanthoma: multiple association in a patient with chronic lymphatic leukaemia. (12410728)
2002
48
Differentiation between merkel cell carcinoma and malignant melanoma: An immunohistochemical study. (11053914)
2000
49
Gingival metastasis of merkel cell carcinoma: a case report. (8850357)
1996
50
Multiple hamartoma syndrome (Cowden's disease) associated with renal cell carcinoma and primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma). (1575215)
1992

Genetic Variations for Merkel Cell Carcinoma

About this section

Expression for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Merkel Cell Carcinoma

Search GEO for disease gene expression data for Merkel Cell Carcinoma.

Pathways for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
4Cell Signaling Technology, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5S100B, NKX2-1, SYP, POU3F2
210.4ASCL1, POU3F2, ATOH1
310.4KIT, CD37, DNTT

Compounds for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1mucicarmine4410.8S100B, PIP, NKX2-1, SYP, KRT20
2hematoxylin4410.8S100B, NKX2-1, SYP, KIT, KRT20
3b 7234410.7KRT20, SYP, NKX2-1, PIP, S100B
4formaldehyde44 2411.7S100B, NKX2-1, SYP, KIT, KRT20
5paraffin4410.7KRT20, S100B, PIP, NKX2-1, SYP, DNTT
6progesterone44 59 28 11 2414.7S100B, PIP, NKX2-1, SYP, B3GAT1, KIT
7l-amino acid4410.7S100B, SYP, POU3F2
8testosterone44 59 11 2413.7S100B, PIP, SYP, B3GAT1, KIT, KRT20
9steroid4410.7POU2F2, SYP, NKX2-1, PIP
10naphthol as-d chloroacetate4410.6DNTT, KIT
11serine4410.6S100B, NKX2-1, SYP, POU2F2, DNTT, AXIN2
12s 1004410.6SYP, S100B
13tyrosine4410.6S100B, NKX2-1, SYP, POU2F2, KIT, KRT20
14retinoic acid44 2411.5S100B, NKX2-1, SYP, DNTT, KIT, ASCL1
15glycogen44 2411.5KIT, AXIN2, SYP, S100B
16p0034410.5S100B, EPCAM, KIT
17reticulin4410.4SYP, S100B
18oligonucleotide4410.1NKX2-1, POU3F2, POU2F2, DNTT, KIT

GO Terms for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.6ASCL1, NKX2-1
2negative regulation of myeloid dendritic cell activationGO:03088610.5TSPAN32, CD37
3cellular response to organic substanceGO:07131010.5POU3F2, SYP
4regulation of defense response to virusGO:05068810.5TSPAN32, CD37
5neuron migrationGO:00176410.4ATOH1, NKX2-1, ASCL1
6defense response to protozoanGO:04283210.1TSPAN32, CD37

Molecular functions related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.4NKX2-1, POU4F3, POU3F2, POU2F2, ASCL1, ATOH1
2sequence-specific DNA bindingGO:04356510.1ASCL1, POU2F2, POU3F2, POU4F3, NKX2-1, ATOH1

Products for genes affiliated with Merkel Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Merkel Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet