MCID: MRK001
MIFTS: 54

Merkel Cell Carcinoma malady

Cancer diseases category

Summaries for Merkel Cell Carcinoma

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Merkel cell carcinoma is a rare type of skin cancer that appears as a painless, hardened, red to purplish bump.  it occurs primarily in sun-exposed skin of the head and neck, though it can also occur on the skin of the arms, legs, and trunk.  it is considered fast-growing (aggressive), meaning that it can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body.  merkel cell carcinoma is diagnosed by biopsy, when some of the tissue is removed and examined under a microscope.  in 2007, approximately 1500 people in the united states were diagnosed with this type of cancer.  treatment depends on the size of the cancer and the extent to which it has spread as determined by imaging studies. last updated: 5/28/2011

MalaCards: Merkel Cell Carcinoma, also known as trabecular adenocarcinoma, is related to neuroendocrine carcinoma and squamous cell carcinoma. An important gene associated with Merkel Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Neuroscience and Transcription factors in neurogenesis. The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and thyroid, and related mouse phenotypes are no phenotypic analysis and cellular.

Wikipedia:63 Merkel cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by a... more...

Aliases & Classifications for Merkel Cell Carcinoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

merkel cell carcinoma 8 42 10 60
trabecular adenocarcinoma 8 60
carcinoma, merkel cell 42
carcinoma merkel cell 44
trabecular carcinoma 8
merkel cell cancer 42
merkle tumors 42


External Ids:

Disease Ontology8 DOID:3965
SNOMED-CT56 29792007
NCIt39 C4068

Related Diseases for Merkel Cell Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Merkel Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.2S100B, NKX2-1, SYP, KIT, KRT20, ASCL1
2squamous cell carcinoma30.9PIP, NKX2-1, SYP, CD151, EPCAM, KRT20
3large cell carcinoma30.8KRT20, SYP, NKX2-1
4melanoma30.7S100B, NKX2-1, POU3F2, CD151, EPCAM, KIT
5lung small cell carcinoma30.6NKX2-1, SYP, CD99, EPCAM, KIT, KRT20
6sarcoma30.6S100B, CD99, B3GAT1, KIT
7retinoblastoma30.6SYP, EPCAM
8neuroendocrine tumor30.4NKX2-1, SYP, KRT20, ASCL1
9paraganglioma30.2S100B, SYP, KIT
10neuroblastoma30.2SYP
11adenocarcinoma30.2PIP, NKX2-1, SYP, EPCAM, KRT20, ASCL1
12rhabdomyosarcoma30.2CD99, S100B
13pheochromocytoma30.2ASCL1, SYP
14kidney cancer30.2NKX2-1, EPCAM, KIT, KRT20
15small cell carcinoma10.7
16chronic lymphocytic leukemia10.5
17leukemia10.5
18basal cell carcinoma10.5
19in situ carcinoma10.5
20thyroiditis10.5
21renal cell carcinoma10.5
22bone carcinoma10.4
23pancreatitis10.4
24transitional cell carcinoma10.4
25dermatofibrosarcoma10.3
26lymphoepithelioma-like carcinoma10.3
27kaposi's sarcoma10.3
28adrenal carcinoma10.3
29epidermodysplasia verruciformis10.3
30myeloma10.3
31skin disease10.3
32merkel cell carcinoma, somatic10.3
33cutaneous neuroendocrine carcinoma10.3
34cardiac tamponade10.1
35pancreatic endocrine carcinoma10.1
36actinic keratosis10.1
37somatostatinoma10.1
38psoriatic arthritis10.1
39pancytopenia10.1
40penile neoplasm10.1
41adult xanthogranuloma10.1
42pityriasis rubra pilaris10.1
43skin glomus tumor10.1
44tonsillitis10.1
45differentiating neuroblastoma10.1
46duodenitis10.1
47sporotrichosis10.1
48insulinoma10.1
49retroperitoneum carcinoma10.1
50arthritis10.1

Graphical network of the top 20 diseases related to Merkel Cell Carcinoma:



Diseases related to merkel cell carcinoma

Clinical Features for Merkel Cell Carcinoma

About this section

Drugs & Therapeutics for Merkel Cell Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Merkel Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Merkel Cell Carcinoma

Search NIH Clinical Center for Merkel Cell Carcinoma

Search CenterWatch for Merkel Cell Carcinoma

Genetic Tests for Merkel Cell Carcinoma

About this section

Anatomical Context for Merkel Cell Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Merkel Cell Carcinoma:

32
Skin, Lymph node, Thyroid, Pancreas, Lung, Kidney, B cells, T cells, Breast, Bone marrow, Bone, Heart, Endothelial, Pituitary, Colon, Salivary gland, Adrenal gland, Tonsil

Animal Models for Merkel Cell Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Merkel Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.5ATOH1, NKX2-1, EPCAM, KIT, ASCL1, SYP
2MP:000538410.4TSPAN32, ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2
3MP:000363110.4B3GAT1, EPCAM, AXIN2, POU3F2, POU4F3, NKX2-1
4MP:000287310.3ASCL1, AXIN2, DNTT, S100B, POU4F3, SYP
5MP:000537910.1KIT, POU3F2, EPCAM, AXIN2, NKX2-1, ATOH1

Publications for Merkel Cell Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Merkel Cell Carcinoma:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I. (24432305)
2014
2
Clinical, dermoscopic and histological features of a Merkel cell carcinoma of the hand. (23580909)
2013
3
The Merkel cell carcinoma challenge: a review from the fine needle aspiration service. (23225406)
2013
4
The important role of radiation treatment in the management of Merkel cell carcinoma. (23898924)
2013
5
Merkel cell carcinoma: a primer for the radiologist. (23701052)
2013
6
A merkel cell carcinoma of the lacrimal gland. (21743373)
2012
7
The spectrum of Merkel cell polyomavirus expression in Merkel cell carcinoma, in a variety of cutaneous neoplasms, and in neuroendocrine carcinomas from different anatomical sites. (21940035)
2012
8
Radiotherapy for metastatic merkel cell carcinoma: a review of the literature. (22811917)
2012
9
Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma. (22072529)
2012
10
Expression of CXCR4, E-cadherin, Bcl-2, and survivin in Merkel cell carcinoma: an immunohistochemical study using a tissue microarray. (22814318)
2012
11
Clinical stage of Merkel cell carcinoma and survival are not associated with Breslow thickness of biopsied tumor. (22455371)
2012
12
Merkel cell carcinoma. (23116583)
2012
13
Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma. (22166964)
2012
14
Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study. (22467679)
2012
15
High levels of antibodies against merkel cell polyomavirus identify a subset of patients with merkel cell carcinoma with better clinical outcome. (21422439)
2011
16
Giant merkel cell carcinoma masquerading as a benign cyst on the buttock of an african american man. (22606448)
2011
17
Merkel cell carcinoma: banal-appearing, aggressive actor. (21720667)
2011
18
A review of the epidemiology and treatment of Merkel cell carcinoma. (22012057)
2011
19
Recent advances in the biology of Merkel cell carcinoma. (21641014)
2011
20
Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review. (20668913)
2011
21
A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331). (20019577)
2010
22
Complete spontaneous regression of metastatic merkel cell carcinoma: a case report and review of the literature. (20520522)
2010
23
Patients with clinically node negative extremity Merkel cell carcinoma: The importance of identifying and treating patients with microscopic nodal metastases. (21198525)
2010
24
Bilateral renal metastases in a case of Merkel cell carcinoma. (21119275)
2010
25
Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study. (20061203)
2010
26
Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patients. (20689250)
2010
27
Merkel cell carcinoma. Pathological and molecular aspects of diagnosis and clinical features. (21225493)
2010
28
Merkel cell carcinoma of the hand: case report and literature review. (20202882)
2010
29
Merkel cell carcinoma of the alveolar mucosa in a young adult: a rare case report. (19167791)
2010
30
Right atrial Merkel cell carcinoma metastasis. (20117465)
2010
31
Merkel cell carcinoma in a kidney transplant patient: Case report and update on management. (20877269)
2010
32
Merkel cell carcinoma of the vulva. (19417978)
2009
33
Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). (19396152)
2009
34
Merkel cell carcinoma: recent progress and current priorities on etiology, pathogenesis, and clinical management. (19597021)
2009
35
Merkel cell carcinoma associated with in situ and invasive squamous cell carcinoma. (19326009)
2009
36
Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma. (19709861)
2009
37
Merkel cell carcinoma: case report and literature review, from a remote region of France. (19206996)
2009
38
Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases. (18813128)
2009
39
Treatment of in-transit metastases from Merkel cell carcinoma with isolated hyperthermic limb infusion. (19097544)
2008
40
Case 19-2008: Merkel-cell carcinoma. (18843131)
2008
41
Expression of HuR in Merkel cell carcinoma and in normal skin. (18095988)
2008
42
An unusual presentation of merkel cell carcinoma of the eyelid. (18716977)
2008
43
Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung. (16625069)
2006
44
Cell cycle control by p21, p27 and p53 in Merkel cell carcinoma. (16821588)
2006
45
KIT receptor (CD117) expression in Merkel cell carcinoma. (14996126)
2004
46
MOC-31/Ep-CAM immunoreactivity in Merkel cells and Merkel cell carcinomas. (14636274)
2003
47
Intraepidermal Merkel cell carcinoma with no dermal involvement. (10698220)
2000
48
Status of cytokine and antigen presentation genes in Merkel cell carcinoma of the skin. (9479078)
1998
49
Selective lymphadenectomy in patients with Merkel cell (cutaneous neuroendocrine) carcinoma. (9259965)
1997
50
A case of Merkel cell carcinoma of the eyelid]. (2403049)
1990

Genetic Variations for Merkel Cell Carcinoma

About this section

Expression for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Merkel Cell Carcinoma

Search GEO for disease gene expression data for Merkel Cell Carcinoma.

Pathways for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
4Cell Signaling Technology, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5POU3F2, S100B, NKX2-1, SYP
210.4ATOH1, POU3F2, ASCL1
310.4KIT, DNTT, CD37

Compounds for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1mucicarmine4410.8S100B, PIP, NKX2-1, SYP, KRT20
2hematoxylin4410.8S100B, NKX2-1, SYP, KIT, KRT20
3b 7234410.7KRT20, SYP, NKX2-1, PIP, S100B
4formaldehyde44 2411.7S100B, NKX2-1, SYP, KIT, KRT20
5paraffin4410.7KRT20, S100B, PIP, NKX2-1, SYP, DNTT
6progesterone44 59 28 11 2414.7S100B, PIP, NKX2-1, SYP, B3GAT1, KIT
7l-amino acid4410.7S100B, SYP, POU3F2
8testosterone44 59 11 2413.7S100B, PIP, SYP, B3GAT1, KIT, KRT20
9steroid4410.7POU2F2, SYP, NKX2-1, PIP
10naphthol as-d chloroacetate4410.6DNTT, KIT
11serine4410.6S100B, NKX2-1, SYP, POU2F2, DNTT, AXIN2
12s 1004410.6SYP, S100B
13tyrosine4410.6S100B, NKX2-1, SYP, POU2F2, KIT, KRT20
14retinoic acid44 2411.5S100B, NKX2-1, SYP, DNTT, KIT, ASCL1
15glycogen44 2411.5KIT, AXIN2, SYP, S100B
16p0034410.5S100B, EPCAM, KIT
17reticulin4410.4SYP, S100B
18oligonucleotide4410.1NKX2-1, POU3F2, POU2F2, DNTT, KIT

GO Terms for genes affiliated with Merkel Cell Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.6ASCL1, NKX2-1
2negative regulation of myeloid dendritic cell activationGO:03088610.5CD37, TSPAN32
3cellular response to organic substanceGO:07131010.5POU3F2, SYP
4regulation of defense response to virusGO:05068810.5CD37, TSPAN32
5neuron migrationGO:00176410.4ASCL1, ATOH1, NKX2-1
6defense response to protozoanGO:04283210.1TSPAN32, CD37

Molecular functions related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.4ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2, ASCL1
2sequence-specific DNA bindingGO:04356510.1ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2, ASCL1

Products for genes affiliated with Merkel Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Merkel Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet