MCID: MRK001
MIFTS: 52

Merkel Cell Carcinoma malady

Cancer category

Summaries for Merkel Cell Carcinoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Merkel cell carcinoma is a rare type of skin cancer that appears as a painless, hardened, red to purplish bump.  it occurs primarily in sun-exposed skin of the head and neck, though it can also occur on the skin of the arms, legs, and trunk.  it is considered fast-growing (aggressive), meaning that it can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body.  merkel cell carcinoma is diagnosed by biopsy, when some of the tissue is removed and examined under a microscope.  in 2007, approximately 1500 people in the united states were diagnosed with this type of cancer.  treatment depends on the size of the cancer and the extent to which it has spread as determined by imaging studies. last updated: 5/28/2011

MalaCards: Merkel Cell Carcinoma, also known as trabecular adenocarcinoma, is related to neuroendocrine carcinoma and squamous cell carcinoma. An important gene associated with Merkel Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Neuroscience and Transcription factors in neurogenesis. The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are no phenotypic analysis and cellular.

Wikipedia:64 Merkel cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by a... more...

Aliases & Classifications for Merkel Cell Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 45Novoseek, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

merkel cell carcinoma 8 43 10 61
trabecular adenocarcinoma 8 61
carcinoma, merkel cell 43
carcinoma merkel cell 45
trabecular carcinoma 8
merkel cell cancer 43
merkle tumors 43


External Ids:

Disease Ontology8 DOID:3965
SNOMED-CT57 29792007
NCIt40 C4068

Related Diseases for Merkel Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Merkel Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.2S100B, NKX2-1, SYP, KIT, KRT20, ASCL1
2squamous cell carcinoma31.0PIP, NKX2-1, SYP, CD151, EPCAM, KRT20
3large cell carcinoma30.9KRT20, SYP, NKX2-1
4paraganglioma30.2S100B, SYP, KIT
5adenocarcinoma30.2PIP, NKX2-1, SYP, EPCAM, KRT20, ASCL1
6pheochromocytoma30.2ASCL1, SYP
7small cell carcinoma10.8
8eye carcinoma10.7
9eyelid carcinoma10.7
10cutaneous neuroendocrine carcinoma10.7
11basal cell carcinoma10.5
12leukemia, b-cell, chronic10.4
13b-cell chronic lymphocytic leukemia10.4
14bone carcinoma10.4
15kaposi's sarcoma10.4
16t-cell leukemia10.4
17leukemia, t-cell, chronic10.4
18dermatofibrosarcoma10.3
19adrenal carcinoma10.3
20epidermodysplasia verruciformis10.3
21basal cell carcinoma, multiple10.3
22dermatofibrosarcoma protuberans10.3
23merkel cell carcinoma, somatic10.3
24cardiac tamponade10.1
25squamous cell papilloma10.1
26pancreatic endocrine carcinoma10.1
27actinic keratosis10.1
28somatostatinoma10.1
29anal carcinoma in situ10.1
30psoriatic arthritis10.1
31pancytopenia10.1
32penile neoplasm10.1
33adult xanthogranuloma10.1
34pityriasis rubra pilaris10.1
35skin glomus tumor10.1
36cowden disease10.1
37differentiating neuroblastoma10.1
38sporotrichosis10.1
39insulinoma10.1
40n syndrome10.1
41retroperitoneum carcinoma10.1
42arthritis10.1
43skin squamous cell carcinoma10.1
44t cell deficiency10.1
45vulvar disease10.1
46b-cell lymphomas10.1
47lentigo maligna melanoma10.1
48kid syndrome10.1
49warfarin sensitivity10.1
50somatostatin analog10.1

Graphical network of the top 20 diseases related to Merkel Cell Carcinoma:



Diseases related to merkel cell carcinoma

Clinical Features for Merkel Cell Carcinoma

Drugs & Therapeutics for Merkel Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Merkel Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Merkel Cell Carcinoma

Search NIH Clinical Center for Merkel Cell Carcinoma

Search CenterWatch for Merkel Cell Carcinoma

Genetic Tests for Merkel Cell Carcinoma

Anatomical Context for Merkel Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Merkel Cell Carcinoma:

33
Bone marrow, Whole blood, Lymph node, Heart, Colon, Kidney, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Tonsil, T cells, B cells, Endothelial, Pituitary

Animal Models for Merkel Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Merkel Cell Carcinoma

Sources:
51PubMed
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Articles related to Merkel Cell Carcinoma:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
A practical update of surgical management of merkel cell carcinoma of the skin. (23431473)
2013
2
Successful local control of cutaneous Merkel cell carcinoma on the eyelid with CyberKnife radiosurgery. (24063985)
2013
3
Imaging in patients with merkel cell carcinoma. (23476783)
2013
4
Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype. (23672777)
2013
5
Secondary merkel cell carcinoma manifested in the parotid. (24377051)
2013
6
Merkel cell carcinoma: complete clinical remission associated with disease progression. (23715411)
2013
7
The prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinoma. (23517683)
2013
8
Merkel cell carcinoma of the upper eyelid: presentation and management. (23219709)
2013
9
Commentary: Merkel cell carcinoma: bridging the gap. (23387357)
2013
10
Merkel cell polyomavirus-positive Merkel cell carcinoma cells do not require expression of the viral small T antigen. (23439392)
2013
11
Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus. (22976527)
2012
12
Merkel cell carcinoma in a patient with noninvasive vulvar Paget's disease. (22503648)
2012
13
Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status. (22649735)
2012
14
Unusual Merkel cell carcinoma of the eyelid. (22681577)
2012
15
Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based study. (22331952)
2012
16
Prevalence of human polyomaviruses in common and rare types of non-Merkel cell carcinoma skin cancer. (22803598)
2012
17
68Ga-DOTATATE-PET/CT positive metastatic lymph node in a 69-year-old woman with Merkel cell carcinoma. (22996252)
2012
18
Association of Merkel cell polyomavirus infection with clinicopathological differences in Merkel cell carcinoma. (22795182)
2012
19
Merkel cell carcinoma presenting in a young patient as a forme fruste of variant epidermodysplasia verruciformis. (21839331)
2011
20
Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors. (21887929)
2011
21
P53 mutation is a rare event in Merkel cell carcinoma of the head and neck. (21331782)
2011
22
Use of interferon-alpha in two patients with Merkel cell carcinoma positive for Merkel cell polyomavirus. (20825355)
2011
23
Abscopal effect in a patient with metastatic Merkel cell carcinoma following radiation therapy: potential role of induced antitumor immunity. (21768497)
2011
24
In-transit Merkel cell carcinoma treated with isolated limb perfusion or isolated limb infusion: a case series of 12 patients. (21324044)
2011
25
Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma. (20949558)
2011
26
Detection of Merkel cell polyomavirus in cutaneous squamous cell carcinoma before occurrence of Merkel cell carcinoma. (22000888)
2011
27
The etiology and epidemiology of merkel cell carcinoma. (20371072)
2010
28
Merkel cell carcinoma of the breast: CT-scan and histologic finding. (20459435)
2010
29
Spontaneous regression of advanced merkel-cell-like small cell carcinoma of the parotid gland. (19619917)
2010
30
Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression. (20118909)
2010
31
Merkel cell carcinoma of the inguinal lymph node with an unknown primary site. (19335694)
2009
32
Reactivation and mutation of newly discovered WU, KI, and Merkel cell carcinoma polyomaviruses in immunosuppressed individuals. (19090778)
2009
33
G3139 (Genasense) in patients with advanced merkel cell carcinoma. (19307957)
2009
34
Merkel cell carcinoma with an unusual immunohistochemical profile. (22073365)
2009
35
Remission of extensive merkel cell carcinoma after electrochemotherapy. (19380682)
2009
36
A Merkel cell carcinoma treatment algorithm. (19528393)
2009
37
Single-institution series of early-stage Merkel cell carcinoma: long-term outcomes in 95 patients managed with surgery alone. (19609619)
2009
38
Merkel cell carcinoma metastasis and dermatofibrosarcoma protuberans presenting as a collision tumour: a case report and review of the literature. (19830210)
2009
39
Merkel cell carcinoma in situ arising in a trichilemmal cyst: a case report and literature review. (18806489)
2008
40
Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience. (18767173)
2008
41
Merkel cell carcinoma: molecular pathogenesis, clinical features and therapy. (19000060)
2008
42
Short German guidelines: Merkel cell carcinoma. (18801136)
2008
43
p63 expression as a new prognostic marker in Merkel cell carcinoma. (17599745)
2007
44
Expression of vascular endothelial growth factor receptor-2 in Merkel cell carcinoma. (17695419)
2007
45
Feline cutaneous neuroendocrine carcinoma (Merkel cell tumour): clinical and pathological findings. (12662269)
2003
46
Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas). (12834484)
2003
47
Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. (10027519)
1999
48
Neuroendocrine carcinoma of the breast with Merkel cell carcinoma-like features. (9701020)
1998
49
Mixed Merkel cell carcinoma and squamous cell carcinoma of the skin. (9810922)
1998
50
Aberrant FHIT transcripts in Merkel cell carcinoma. (8653678)
1996

Genetic Variations for Merkel Cell Carcinoma

Expression for genes affiliated with Merkel Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Merkel Cell Carcinoma

Search GEO for disease gene expression data for Merkel Cell Carcinoma.

Pathways for genes affiliated with Merkel Cell Carcinoma

Sources:
4Cell Signaling Technology, 12EMD Millipore, 30KEGG
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Pathways related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5S100B, NKX2-1, SYP, POU3F2
210.4ASCL1, POU3F2, ATOH1
310.4KIT, CD37, DNTT

Compounds for genes affiliated with Merkel Cell Carcinoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank
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Compounds related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1mucicarmine4510.8S100B, PIP, NKX2-1, SYP, KRT20
2hematoxylin4510.8S100B, NKX2-1, SYP, KIT, KRT20
3b 7234510.7KRT20, SYP, NKX2-1, PIP, S100B
4formaldehyde45 2411.7S100B, NKX2-1, SYP, KIT, KRT20
5paraffin4510.7KRT20, S100B, PIP, NKX2-1, SYP, DNTT
6progesterone45 60 29 11 2414.7S100B, PIP, NKX2-1, SYP, B3GAT1, KIT
7l-amino acid4510.7S100B, SYP, POU3F2
8testosterone45 60 11 2413.7S100B, PIP, SYP, B3GAT1, KIT, KRT20
9steroid4510.7POU2F2, SYP, NKX2-1, PIP
10naphthol as-d chloroacetate4510.6DNTT, KIT
11serine4510.6S100B, NKX2-1, SYP, POU2F2, DNTT, AXIN2
12s 1004510.6SYP, S100B
13tyrosine4510.6S100B, NKX2-1, SYP, POU2F2, KIT, KRT20
14retinoic acid45 2411.5S100B, NKX2-1, SYP, DNTT, KIT, ASCL1
15glycogen45 2411.5KIT, AXIN2, SYP, S100B
16p0034510.5S100B, EPCAM, KIT
17reticulin4510.4SYP, S100B
18oligonucleotide4510.1NKX2-1, POU3F2, POU2F2, DNTT, KIT

GO Terms for genes affiliated with Merkel Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.6ASCL1, NKX2-1
2negative regulation of myeloid dendritic cell activationGO:03088610.5TSPAN32, CD37
3cellular response to organic substanceGO:07131010.5POU3F2, SYP
4regulation of defense response to virusGO:05068810.5TSPAN32, CD37
5neuron migrationGO:00176410.4ATOH1, NKX2-1, ASCL1
6defense response to protozoanGO:04283210.1TSPAN32, CD37

Molecular functions related to Merkel Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.4ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2, ASCL1
2sequence-specific DNA bindingGO:04356510.1ATOH1, NKX2-1, POU4F3, POU3F2, POU2F2, ASCL1

Products for genes affiliated with Merkel Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Merkel Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet