MCID: MRR006
MIFTS: 12

Merrf/melas Overlap Syndrome malady

Summaries for Merrf/melas Overlap Syndrome

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33MalaCards
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MalaCards: Merrf/melas Overlap Syndrome is related to merrf syndrome and melas syndrome. An important gene associated with Merrf/melas Overlap Syndrome is MT-TH (mitochondrially encoded tRNA histidine), and among its related pathways is tRNA Aminoacylation.

Aliases & Classifications for Merrf/melas Overlap Syndrome

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20GeneTests, 22GTR
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Aliases & Descriptions:

merrf/melas overlap syndrome 20 22


Related Diseases for Merrf/melas Overlap Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Merrf/melas Overlap Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1merrf syndrome10.8
2melas syndrome10.8
33-m syndrome10.5
4mitochondrial dna-associated leigh syndrome and narp10.0MT-TK, MT-TL1
5mitochondrial disorders10.0MT-TH, MT-TK, MT-TL1

Graphical network of diseases related to Merrf/melas Overlap Syndrome:



Diseases related to merrf/melas overlap syndrome

Clinical Features for Merrf/melas Overlap Syndrome

Drugs & Therapeutics for Merrf/melas Overlap Syndrome

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Merrf/melas Overlap Syndrome

Drug clinical trials:

Search ClinicalTrials for Merrf/melas Overlap Syndrome

Search NIH Clinical Center for Merrf/melas Overlap Syndrome

Search CenterWatch for Merrf/melas Overlap Syndrome

Genetic Tests for Merrf/melas Overlap Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Merrf/melas Overlap Syndrome:

id Genetic test Affiliating Genes
1 Merrf/melas Overlap Syndrome20 22 MT-TH

Anatomical Context for Merrf/melas Overlap Syndrome

Animal Models for Merrf/melas Overlap Syndrome or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Merrf/melas Overlap Syndrome

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51PubMed
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Articles related to Merrf/melas Overlap Syndrome:

idTitleAuthorsYear
1
MERRF/MELAS overlap syndrome due to the m.3291T>C mutation. (24338029)
2013
2
MERRF/MELAS overlap syndrome: a double pathogenic mutation in mitochondrial tRNA genes. (20610441)
2010
3
MERRF/MELAS overlap syndrome in a family with A3243G mtDNA mutation. (12005255)
2002
4
Sporadic MERRF/MELAS overlap syndrome associated with the 3243 tRNA(Leu(UUR)) mutation of mitochondrial DNA. (8559168)
1996
5
A novel point mutation in the mitochondrial tRNA(Ser(UCN)) gene detected in a family with MERRF/MELAS overlap syndrome. (7669057)
1995
6
A MERRF/MELAS overlap syndrome associated with a new point mutation in the mitochondrial DNA tRNA(Lys) gene. (8069654)
1993

Genetic Variations for Merrf/melas Overlap Syndrome

Expression for genes affiliated with Merrf/melas Overlap Syndrome

Sources:
15Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Merrf/melas Overlap Syndrome.

Pathways for genes affiliated with Merrf/melas Overlap Syndrome

Sources:
54Reactome, 30KEGG
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Pathways related to Merrf/melas Overlap Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.5MT-TH, MT-TK, MT-TL1

Compounds for genes affiliated with Merrf/melas Overlap Syndrome

GO Terms for genes affiliated with Merrf/melas Overlap Syndrome

Products for genes affiliated with Merrf/melas Overlap Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Merrf/melas Overlap Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet