MCID: MSN001
MIFTS: 41

Mesangial Proliferative Glomerulonephritis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

MalaCards integrated aliases for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 12 50 14 69
Glomerulonephritis - Mesangial Proliferative 50
Glomerulonephritis Mesangial Proliferative 52
Mesangioproliferative Glomerulonephritis 50
Mesangial Proliferative Gn 50

Classifications:



External Ids:

Disease Ontology 12 DOID:4783
NCIt 47 C35445
SNOMED-CT 64 35546006
UMLS 69 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

NIH Rare Diseases : 50 mesangial proliferative glomerulonephritis (mpgn) is a condition that affects the kidneys. many experts consider it a variant of minimal change disease, but some experts believe it is a separate condition. it may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. it can also present with blood in the urine (hematuria). mpgn is characterized by an increased number of mesangial cells in the glomeruli in the kidneys and damage to the glomeruli. glomeruli are the structures that help filter wastes and fluids. mpgn may occur in several renal diseases such as iga nephropathy (commonly), igm nephropathy, lupus nephritis, and c1q nephropathy. however, in some cases, the underlying cause of mpgn remains unclear. treatment may depend on the cause (if known) and may include steroids, mycophenolate mofetil, and/or cyclophosphamide, and other therapies to treat specific symptoms. most people with mpgn have a good prognosis, but some may develop chronic kidney disease, which can progress to end stage renal failure. last updated: 7/13/2017

MalaCards based summary : Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to c1q deficiency and glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Losartan and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related phenotype is renal/urinary system.

Wikipedia : 72 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

Related Diseases for Mesangial Proliferative Glomerulonephritis

Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 c1q deficiency 11.3
2 glomerulonephritis 10.9
3 proliferative glomerulonephritis 10.9
4 scrotal carcinoma 10.6 FGF2 IL6
5 schwannoma of ureter 10.6 CCL2 IL6
6 antigen-peptide-transporter 2 deficiency 10.6 CCL2 IL6
7 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.6 CCL2 IL6
8 islet cell tumor 10.6 CCL2 IL6
9 pasteurellosis 10.5 EDN1 IL6
10 neuroaxonal dystrophy 10.5 CCL2 IL6
11 hyperaldosteronism 10.5 CCL2 IL6
12 myofascial pain syndrome 10.5 CCL2 IL6
13 cranial nerve malignant neoplasm 10.5 CCL2 FGF2
14 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.5 CCL2 IL6
15 allergic bronchopulmonary aspergillosis 10.5 CCL2 IL6
16 ovarian mucinous adenofibroma 10.4 CCL2 IL6
17 ostertagiasis 10.4 CCL2 IL6
18 peripheral retinal degeneration 10.4 AXL IL6
19 pneumoconiosis 10.4 CCL2 IL6
20 generalized atherosclerosis 10.4 CD79A IL6
21 neonatal diabetes mellitus 10.3 CCL2 EDN1
22 lymphocytic colitis 10.3 CD79A IL6
23 indolent myeloma 10.3 CD79A IL6
24 immune-complex glomerulonephritis 10.3 CD79A FGF2
25 bullous retinoschisis 10.3 CD79A IL6
26 osmotic diarrhea 10.3 CCL2 IL6
27 ariboflavinosis 10.3 CD79A IL6
28 philophthalmiasis 10.3 CD79A IL6
29 nephrotic syndrome 10.3
30 lichen planus 10.3 CCL2 FGF2 IL6
31 focal dystonia 10.3 CCL2 FGF2 IL6
32 uveitis 10.3 CCL2 CD79A
33 hypogonadotropism 10.3 CD79A IL6
34 silver-russell syndrome due to 11p15 microduplication 10.3 EDN1 FGF2
35 optic nerve hypoplasia 10.3 CCL2 FGF2 IL6
36 glomerulosclerosis, focal segmental, 4 10.3
37 focal segmental glomerulosclerosis 10.3
38 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.3
39 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.3
40 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 10.3
41 blackwater fever 10.3 CD79A EDN1
42 lateral cystocele 10.3 CD79A IL6
43 renal fibrosis 10.3 EDN1 FGF2 IL6
44 angiomatous meningioma 10.2 CD79A IL6
45 high pressure neurological syndrome 10.2 CCL2 EDN1 IL6
46 granulomatous orchitis 10.2 CCL2 EDN1 IL6
47 cholera 10.2 CD79A IL6
48 myelophthisic anemia 10.2 CCL2 EDN1 IL6
49 foodborne botulism 10.2 CD79A IL6
50 peripheral artery disease 10.2 CCL2 EDN1 IL6

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to Mesangial Proliferative Glomerulonephritis

Symptoms & Phenotypes for Mesangial Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 CCR1 CD79A EDN1 GAS6 IL6

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Ramipril Approved Phase 4 87333-19-5 5362129
3
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
4 Angiotensin II Type 1 Receptor Blockers Phase 4
5 Angiotensin Receptor Antagonists Phase 4
6 Angiotensin-Converting Enzyme Inhibitors Phase 4
7 Angiotensinogen Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Antihypertensive Agents Phase 4
10 HIV Protease Inhibitors Phase 4
11 Immunoglobulin A Phase 4
12
protease inhibitors Phase 4
13 Serine Proteinase Inhibitors Phase 4
14 Vasoconstrictor Agents Phase 4
15 serine Nutraceutical Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
2 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

39
Kidney, Endothelial, T Cells, Lung, Brain, Monocytes

Publications for Mesangial Proliferative Glomerulonephritis

Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50) (show all 143)
id Title Authors Year
1
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
2
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
3
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
4
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
5
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
6
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
7
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
8
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
9
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. ( 22641568 )
2013
10
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
11
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. ( 24649023 )
2013
12
Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report. ( 22261745 )
2013
13
Efficacy of antisense monocyte chemoattractant protein-1 (MCP-1) in a rat model of mesangial proliferative glomerulonephritis. ( 23991758 )
2013
14
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis. ( 22286178 )
2012
15
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. ( 22607047 )
2012
16
Successful treatment of a mesangial proliferative glomerulonephritis with interstitial nephritis associated with Castleman's disease by an anti-interleukin-6 receptor antibody (tocilizumab). ( 22687845 )
2012
17
Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. ( 22576627 )
2012
18
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. ( 21349934 )
2011
19
Protein kinase C I^ inhibition ameliorates experimental mesangial proliferative glomerulonephritis. ( 21575103 )
2011
20
Primary SjAPgren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child. ( 19902265 )
2010
21
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. ( 20110667 )
2010
22
Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. ( 20030533 )
2009
23
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. ( 19617668 )
2009
24
Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. ( 18480612 )
2008
25
The relation of IgM deposition to clinical parameters and histomorphometry in childhood mesangial proliferative glomerulonephritis. ( 18093746 )
2008
26
Mesangial proliferative glomerulonephritis with or without IgA deposits: the morphological characters in psoriasis vulgaris. ( 18332636 )
2008
27
Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis. ( 18497456 )
2008
28
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. ( 16541204 )
2007
29
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. ( 17717029 )
2007
30
The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. ( 16179805 )
2006
31
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. ( 16807544 )
2006
32
Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. ( 16860199 )
2006
33
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. ( 15917985 )
2006
34
Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature. ( 15971069 )
2005
35
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. ( 16334979 )
2005
36
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. ( 16092667 )
2005
37
All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. ( 15795517 )
2005
38
Effect of lipo-prostaglandin E1 on mesangial proliferative glomerulonephritis in rats. ( 16463661 )
2005
39
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. ( 15947989 )
2005
40
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. ( 16247710 )
2005
41
Gene expression profile in experimental mesangial proliferative glomerulonephritis. ( 15351794 )
2004
42
[Mesangial proliferative glomerulonephritis]. ( 15500128 )
2004
43
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. ( 17642763 )
2004
44
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. ( 14600028 )
2003
45
Mesangial proliferative glomerulonephritis triggered by spleno-renal shunt in a cirrhotic patient. ( 12038661 )
2002
46
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. ( 12371966 )
2002
47
Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. ( 11982588 )
2002
48
Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. ( 12028445 )
2002
49
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. ( 11979343 )
2002
50
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. ( 12375274 )
2002

Variations for Mesangial Proliferative Glomerulonephritis

Expression for Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for Mesangial Proliferative Glomerulonephritis

Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 AXL CCL2 CCR1 FGF2 GAS6 IL6
2
Show member pathways
13.27 AXL CCL2 FGF2 GAS6 IL6 PDGFD
3
Show member pathways
13.02 AXL FGF2 GAS6 IL6 PDGFD
4
Show member pathways
12.95 AXL CCL2 CCR1 FGF2 GAS6 IL6
5
Show member pathways
12.93 AXL CD79A FGF2 GAS6 IL6 PDGFD
6
Show member pathways
12.75 CD79A FGF2 GAS6 IL6 PDGFD
7
Show member pathways
12.56 CCL2 CCR1 FGF2 GAS6 IL6 PDGFD
8
Show member pathways
12.51 AXL CCL2 FGF2 GAS6 IL6 PDGFD
9
Show member pathways
12.47 FGF2 GAS6 IL6 PDGFD
10
Show member pathways
12.29 AXL FGF2 GAS6 IL6 PDGFD
11 11.77 CCR1 CD79A IL6
12 11.74 CCL2 FGF2 IL6
13 11.7 CCL2 EDN1 IL6
14 11.65 CCL2 EDN1 IL6
15 11.59 CD79A FGF2 IL6
16 11.4 FGF2 GAS6 IL6 PDGFD
17 11.19 CCL2 CCR1 IL6
18 11.12 CCL2 IL6
19 10.72 CCL2 EDN1 FGF2 IL6

GO Terms for Mesangial Proliferative Glomerulonephritis

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 AXL CCL2 EDN1 FGF2 GAS6 IL6

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 43)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.97 CCL2 CCR1 GAS6 PTPRQ
2 positive regulation of cell proliferation GO:0008284 9.96 EDN1 FGF2 IL6 PDGFD
3 inflammatory response GO:0006954 9.91 AXL CCL2 CCR1 IL6
4 positive regulation of cell migration GO:0030335 9.85 CCR1 EDN1 PDGFD
5 response to lipopolysaccharide GO:0032496 9.84 CCL2 EDN1 IL6
6 chemotaxis GO:0006935 9.83 CCL2 CCR1 FGF2
7 cytokine-mediated signaling pathway GO:0019221 9.82 CCL2 CCR1 IL6
8 cellular response to lipopolysaccharide GO:0071222 9.8 AXL CCL2 IL6
9 cellular response to tumor necrosis factor GO:0071356 9.8 CCL2 EDN1 IL6
10 cell surface receptor signaling pathway GO:0007166 9.8 CCL2 CCR1 CD79A EDN1
11 platelet activation GO:0030168 9.78 AXL GAS6 IL6
12 positive regulation of protein kinase B signaling GO:0051897 9.74 AXL GAS6 IL6
13 response to wounding GO:0009611 9.7 CCL2 CCR1 IL6
14 negative regulation of tumor necrosis factor production GO:0032720 9.69 AXL GAS6
15 cellular response to estradiol stimulus GO:0071392 9.69 CCL2 IL6
16 cellular response to interleukin-1 GO:0071347 9.69 CCL2 EDN1 IL6
17 regulation of angiogenesis GO:0045765 9.68 FGF2 IL6
18 response to antibiotic GO:0046677 9.68 CCL2 IL6
19 cellular response to dexamethasone stimulus GO:0071549 9.68 CCL2 IL6
20 response to bacterium GO:0009617 9.68 CCL2 IL6
21 negative regulation of interferon-gamma production GO:0032689 9.66 AXL GAS6
22 cellular response to fatty acid GO:0071398 9.66 CCL2 EDN1
23 cellular response to platelet-derived growth factor stimulus GO:0036120 9.65 CCL2 PDGFD
24 cellular response to drug GO:0035690 9.65 CCL2 EDN1 GAS6
25 positive regulation of monocyte chemotaxis GO:0090026 9.64 CCL2 CCR1
26 apoptotic cell clearance GO:0043277 9.63 AXL GAS6
27 cellular response to hydrogen peroxide GO:0070301 9.63 AXL IL6 PDGFD
28 viral genome replication GO:0019079 9.62 CCL2 GAS6
29 positive regulation of MAP kinase activity GO:0043406 9.61 EDN1 FGF2 PDGFD
30 dendritic cell differentiation GO:0097028 9.6 AXL GAS6
31 negative regulation of hormone secretion GO:0046888 9.59 EDN1 IL6
32 enzyme linked receptor protein signaling pathway GO:0007167 9.58 AXL GAS6
33 cellular response to interferon-alpha GO:0035457 9.58 AXL GAS6
34 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 EDN1 IL6 PDGFD
35 maternal process involved in parturition GO:0060137 9.56 CCL2 EDN1
36 positive regulation of natural killer cell differentiation GO:0032825 9.55 AXL GAS6
37 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.54 AXL GAS6
38 animal organ regeneration GO:0031100 9.5 AXL CCL2 GAS6
39 regulation of vascular endothelial growth factor production GO:0010574 9.37 CCL2 IL6
40 protein kinase B signaling GO:0043491 9.33 AXL CCL2 GAS6
41 negative regulation of dendritic cell apoptotic process GO:2000669 9.26 AXL GAS6
42 response to amino acid GO:0043200 9.13 CCL2 EDN1 IL6
43 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.1 CCL2 CCR1 FGF2 GAS6 IL6 PDGFD

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 FGF2 IL6 PDGFD
2 phosphatidylserine binding GO:0001786 9.26 AXL GAS6
3 receptor binding GO:0005102 9.26 CCL2 EDN1 GAS6 IL6
4 cytokine activity GO:0005125 8.92 CCL2 EDN1 FGF2 IL6

Sources for Mesangial Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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