MCID: MSN001
MIFTS: 55

Mesangial Proliferative Glomerulonephritis malady

Rare diseases, Nephrological diseases categories

Summaries for Mesangial Proliferative Glomerulonephritis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

MalaCards: Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to proliferative glomerulonephritis and glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds shikonin and mdms have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and monocytes, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

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9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

mesangial proliferative glomerulonephritis 9 44 63
glomerulonephritis - mesangial proliferative 44
glomerulonephritis mesangial proliferative 46
mesangial proliferative gn 44
increased mesangial matrix 63


External Ids:

Disease Ontology9 DOID:4783
SNOMED-CT59 35546006
NCIt41 C35445

Related Diseases for Mesangial Proliferative Glomerulonephritis

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18GeneCards, 19GeneDecks
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Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative glomerulonephritis32.1CCL2, CD79A
2glomerulonephritis32.0CCL2, CCR5, AGTR1, CD79A
3nephritis30.7CD79A, THY1, CCL2
4acute poststreptococcal glomerulonephritis30.6CD79A
5connective tissue disease30.5CD79A, IL6, CCL2
6proteinuria30.3EDN1, CD79A, THY1, VEGFA, CCL2, AGTR1
7arthritis30.3AGTR1, CCR1, IL6, CCR5, CCL2, FGF2
8myeloma30.2CCR1, VEGFA, IL6, MAPK1, CD79A, FGF2
9nephrotic syndrome10.7
10hepatitis10.5
11familial mediterranean fever10.4
12castleman's disease10.4
13polymyositis10.4
14hepatitis c10.3
15cryoglobulinemia10.3
16legionnaires' disease10.3
17hepatitis a10.3
18mixed connective tissue disease10.3
19hellp syndrome10.3
20interstitial nephritis10.3
21leprosy10.3
22multiple myeloma10.3
23myasthenia gravis10.3
24psoriasis10.3
25urticaria10.3
26steroid-resistant nephrotic syndrome10.3
27c1q deficiency10.3
28hepatitis c virus10.3
29endotheliitis10.3
30sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.3
31familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.3
32idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation10.3
33diabetic macular edema10.1VEGFA
34low renin hypertension10.1EDN1
35central retinal vein occlusion10.1VEGFA
36syphilis10.1CD79A, CCR5
37raynaud disease10.1AGTR1, EDN1
38lipoid nephrosis10.1CCL2, CD79A
39focal segmental glomerulosclerosis10.1CD79A, AGTR1
40cor pulmonale10.1AGTR1, EDN1
41arteriosclerosis10.1CCL2, EDN1
42periapical granuloma10.1CCL2, CCR5
43polyclonal hypergammaglobulinemia10.1CD79A, IL6
44portal hypertension10.1EDN1, AGTR1
45membranous glomerulonephritis10.1CD79A, CCR5, CCL2
46lupus nephritis10.1CCL2, CCR5, CD79A
47type 1 diabetes mellitus10.0CD79A, AGTR1, CCR5
48encephalomyelitis10.0CCL2, CCR1, CCR5
49vascular cancer10.0VEGFA, FGF2
50pulmonary sarcoidosis10.0CCR5, CCL2

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to mesangial proliferative glomerulonephritis

Symptoms for Mesangial Proliferative Glomerulonephritis

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Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mesangial Proliferative Glomerulonephritis

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Anatomical Context for Mesangial Proliferative Glomerulonephritis

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34MalaCards
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MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

34
Brain, Lung, Monocytes, T cells, Endothelial

Animal Models for Mesangial Proliferative Glomerulonephritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4EDN1, VEGFA, CCR1, IL6, CD79A, AGTR1
2MP:00053918.3FGF2, IL6, CCR5, CCL2, VEGFA
3MP:00053708.2VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
4MP:00053818.1EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
5MP:00020068.1VEGFA, CCL2, CCR5, IL6, MAPK1, FGF2
6MP:00053887.8THY1, VEGFA, CCR1, IL6, MAPK1
7MP:00053697.7EDN1, VEGFA, CCL2, CCR5, IL6, MAPK1
8MP:00053877.6VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
9MP:00053977.5VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
10MP:00053867.5VEGFA, PTPRQ, CCL2, CCR5, IL6, MAPK1
11MP:00053847.4VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
12MP:00053857.2EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
13MP:00107687.0EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
14MP:00053766.9EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
15MP:00036316.7FGF2, EDN1, THY1, VEGFA, PTPRQ, CCL2

Publications for Mesangial Proliferative Glomerulonephritis

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53PubMed
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Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
2
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. (22607047)
2012
3
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. (21349934)
2011
4
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
5
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. (17717029)
2007
6
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. (15917985)
2006
7
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
8
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
9
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. (15947989)
2005
10
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
11
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. (14600028)
2003
12
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
13
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. (12375274)
2002
14
Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. (12028445)
2002
15
Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. (11982588)
2002
16
PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. (11260393)
2001
17
Morphometric comparison of the quantity of the mesangial deposits in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (11518047)
2001
18
Ambulatory blood pressure in patients with mesangial proliferative glomerulonephritis. (11688762)
2001
19
Localization in situ of type VI collagen protein and its mRNA in mesangial proliferative glomerulonephritis using renal biopsy sections. (9930877)
1999
20
Experimental mesangial proliferative glomerulonephritis (the anti-Thy-1.1 model). (10630692)
1999
21
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. (9809476)
1998
22
Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis. (9727007)
1998
23
Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. (9808091)
1998
24
Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis. (9773782)
1998
25
Mesangial proliferative glomerulonephritis in chronic obstructive pulmonary disease. (10218320)
1998
26
Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. (8651905)
1996
27
Mesangial proliferative glomerulonephritis and nephrotic syndrome with hepatitis A virus infection. (9141810)
1996
28
Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. (8755633)
1996
29
The novel regulatory mechanism of Fas system-mediated apoptosis in mesangial cells: implication to mesangial proliferative glomerulonephritis. (8619833)
1996
30
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
31
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
32
Mononuclear cell subsets in IgM mesangial proliferative glomerulonephritis. A comparative study with minimal change nephrotic syndrome and immunonegative mesangial proliferative glomerulonephritis. (8247183)
1993
33
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
34
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
35
IgM-associated primary diffuse mesangial proliferative glomerulonephritis: natural history and prognostic indicators. (1852859)
1991
36
Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition. (2044226)
1991
37
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
38
Involvement of IL-6 in mesangial proliferative glomerulonephritis. (2592764)
1989
39
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
40
Mesangial proliferative glomerulonephritis in a patient with hepatic hydatid cysts: a case report in an African male. (3232184)
1988
41
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
42
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
43
Mesangial proliferative glomerulonephritis with Legionnaires' disease. A case report. (3983750)
1985
44
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
45
Mesangial proliferative glomerulonephritis with IgM deposits. Clinicopathologic analysis and evidence for morphologic transitions. (6382035)
1984
46
Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. (6188567)
1983
47
Long term study of mesangial proliferative glomerulonephritis with IgM deposits. (7329978)
1981
48
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
49
Mesangial proliferative glomerulonephritis with irregular intramembranous deposits. Another variant of hypocoplementemic nephritis. (331950)
1977
50
Mesangial proliferative glomerulonephritis in childhood. (4536432)
1973

Variations for Mesangial Proliferative Glomerulonephritis

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Expression for genes affiliated with Mesangial Proliferative Glomerulonephritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for genes affiliated with Mesangial Proliferative Glomerulonephritis

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51PathCards, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 55R&D Systems, 56Reactome, 61Thomson Reuters, 54QIAGEN, 5Cell Signaling Technology, 58SinoBiological
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Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7AGTR1, MAPK1
2
Show member pathways
Peptide GPCRs39
9.7AGTR1, CCR5, CCR1
3
Show member pathways
9.6CCL2, CCR5, CCR1
49.6MAPK1, EDN1
59.5VEGFA, CCL2
69.5IL6, MAPK1
79.5IL6, MAPK1
89.4FGF2, VEGFA
9
Show member pathways
9.3AGTR1, EDN1, MAPK1
10
Show member pathways
9.2MAPK1, PDGFD, FGF2
11
Show member pathways
9.2CCR5, MAPK1, IL6
129.2EDN1, FGF2, MAPK1
13
Show member pathways
9.2CCL2, MAPK1, IL6
149.2MAPK1, IL6, CCL2
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1MAPK1, IL6, EDN1
16
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.1VEGFA, MAPK1, CD79A
17
Show member pathways
9.1CCR5, CCR1, CCL2, MAPK1
189.1VEGFA, IL6, CCL2
19
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.0AGTR1, CD79A, EDN1, MAPK1
20
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.0MAPK1, CCL2, VEGFA
21
Show member pathways
9.0MAPK1, EDN1, VEGFA
22
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.0MAPK1, VEGFA, EDN1
23
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9IL6, MAPK1, CD79A, CCR5
24
Show member pathways
8.9AGTR1, EDN1, CCR1, CCL2, CCR5
258.9FGF2, MAPK1, VEGFA
268.9FGF2, MAPK1, VEGFA
27
Show member pathways
Angiogenesis39
8.9VEGFA, MAPK1, FGF2
28
Show member pathways
8.9VEGFA, MAPK1, FGF2
298.9MAPK1, VEGFA, FGF2
30
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.9MAPK1, IL6, CCR5, CCL2
31
Show member pathways
8.8CD79A, IL6, FGF2, MAPK1
32
Show member pathways
8.8MAPK1, FGF2, IL6, CD79A
33
Show member pathways
8.8IL6, FGF2, MAPK1, CD79A
34
Show member pathways
8.8MAPK1, TGFB1I1, CCR5
358.8MAPK1, EDN1, IL6, CCL2
36
Show member pathways
8.7CCL2, IL6, CCR1, CCR5, FGF2
37
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
8.7TGFB1I1, MAPK1, IL6
38
Show member pathways
Signaling Pathways in Glioblastoma39
8.6VEGFA, MAPK1, FGF2, PDGFD
39
Show member pathways
8.6PDGFD, VEGFA, MAPK1, FGF2
40
Show member pathways
8.5MAPK1, CCR1, CCL2, CCR5, THY1
418.5MAPK1, EDN1, VEGFA, IL6
428.5VEGFA, IL6, MAPK1, FGF2
43
Show member pathways
8.5AGTR1, MAPK1, IL6, CCL2, FGF2
44
Show member pathways
8.5MAPK1, IL6, AGTR1, CCL2, FGF2
45
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.5IL6, MAPK1, AGTR1, FGF2, CCL2
468.1FGF2, MAPK1, VEGFA, IL6, PDGFD
47
Show member pathways
7.9CCL2, FGF2, IL6, CCR1, CCR5, PTPRQ
48
Show member pathways
7.6VEGFA, CCL2, IL6, CCR5, EDN1, CCR1
49
Show member pathways
7.4CCL2, CCR5, CCR1, IL6, MAPK1, FGF2
50
Show member pathways
7.1VEGFA, PDGFD, FGF2, AGTR1, CCL2, MAPK1

Compounds for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1shikonin4610.0CCR1, CCR5, CCL2
2mdms469.9CCR1, CCR5, CCL2
3valsartan46 62 30 1212.8CCL2, EDN1, AGTR1
4mip 1alpha469.8CCL2, IL6, CCR5
5irbesartan46 30 52 1212.7CCL2, EDN1, AGTR1
6gw966246 3010.7MAPK1, AGTR1, CCL2
7ccl346 3010.5CCL2, CCR5, CCR1, IL6
8hcec469.5MAPK1, IL6, CCL2
98-isoprostane469.4EDN1, CCL2, IL6, AGTR1
10tpck469.4MAPK1, IL6, CCL2
11verapamil46 30 52 25 1213.3FGF2, EDN1, AGTR1, CCL2
12ro 31 8220469.3CCL2, VEGFA, MAPK1
13candesartan46 52 30 1212.2CCL2, AGTR1, VEGFA
14vitamin d469.2CCR5, IL6, CD79A, AGTR1, CCL2
15carvedilol46 52 30 1212.2AGTR1, EDN1, VEGFA
16bucillamine469.2VEGFA, CD79A, FGF2, IL6
17norepinephrine46 25 1211.1CCL2, CD79A, AGTR1, IL6, EDN1
18rosiglitazone30 46 52 25 1213.1AGTR1, MAPK1, IL6, CCL2
19histamine46 30 2511.1CCR5, CD79A, EDN1, IL6, CCL2
20tgf beta1469.1IL6, AGTR1, CCL2, FGF2
21cytochalasin d46 6210.1FGF2, MAPK1, CCR5, CCL2
22atorvastatin46 52 30 25 1213.0CCL2, IL6, VEGFA, EDN1
23triptolide468.9MAPK1, IL6, CCL2, VEGFA
24isoproterenol46 129.9FGF2, AGTR1, MAPK1, CCL2, EDN1
25simvastatin46 52 62 30 25 1213.9AGTR1, IL6, VEGFA, CCL2, CCR5
26apocynin46 629.9VEGFA, EDN1, MAPK1
27gf 109203x46 629.8EDN1, VEGFA, FGF2, MAPK1
28prostacyclin468.8CCL2, AGTR1, FGF2, EDN1, VEGFA
29suramin46 30 1210.8FGF2, AGTR1, CD79A, MAPK1, VEGFA
30cyclosporin a46 30 6210.8FGF2, EDN1, CCR5, IL6, CD79A, AGTR1
31herbimycin a46 629.8MAPK1, FGF2, CCL2, EDN1, IL6
32ang ii468.8VEGFA, EDN1, AGTR1, CCL2, MAPK1
33heparin46 30 25 1211.8VEGFA, FGF2, AGTR1, CCR1, CD79A, CCR5
34pd 98,059468.7CCL2, FGF2, MAPK1, IL6, EDN1
35alanine468.6CCR5, CCR1, IL6, AGTR1, FGF2, CD79A
3615-deoxy-delta-12,14-prostaglandin j2468.6MAPK1, VEGFA, FGF2, CCL2, IL6
37phosphatidylinositol468.5CCR1, EDN1, MAPK1, CCL2, FGF2, AGTR1
38hyaluronic acid46 259.4VEGFA, IL6, CD79A, FGF2
39ly294002468.4MAPK1, CCL2, IL6, VEGFA, FGF2
40n acetylcysteine468.4IL6, AGTR1, CD79A, MAPK1, VEGFA, CCL2
41nitric oxide46 25 1210.4CCL2, EDN1, AGTR1, MAPK1, IL6, CCR1
42estrogen468.0VEGFA, CCR5, FGF2, CD79A, IL6, MAPK1
43sb 20358046 628.9IL6, VEGFA, CCL2, MAPK1, AGTR1, FGF2
44genistein46 30 62 3 25 1212.9CCL2, MAPK1, AGTR1, IL6, VEGFA, FGF2
45cycloheximide467.7AGTR1, FGF2, EDN1, VEGFA, CCL2, CCR1
46vegf467.6IL6, MAPK1, FGF2, AGTR1, CD79A, CCL2
47dexamethasone46 52 30 1210.5CCL2, CCR5, CCR1, IL6, FGF2, MAPK1
48pge2467.4CD79A, FGF2, MAPK1, IL6, CCR1, CCR5
49actinomycin d467.4CCL2, EDN1, VEGFA, CCR5, CCR1, IL6
50tyrosine466.7TGFB1I1, VEGFA, THY1, CCR5, CCR1, IL6

GO Terms for genes affiliated with Mesangial Proliferative Glomerulonephritis

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17Gene Ontology
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Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6THY1, CCR5, CCR1, IL6, CD79A
2extracellular spaceGO:0056158.3FGF2, EDN1, VEGFA, IL6, CCL2
3extracellular regionGO:0055767.6FGF2, VEGFA, PDGFD, EDN1, IL6, CCL2

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotaxisGO:09002610.3CCR1, CCR5
2dendritic cell chemotaxisGO:00240710.3CCR1, CCR5
3positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.2AGTR1, EDN1
4maternal process involved in parturitionGO:06013710.1EDN1, CCL2
5regulation of vasoconstrictionGO:01922910.1EDN1, AGTR1
6regulation of vascular endothelial growth factor productionGO:01057410.1IL6, CCL2
7chemokine-mediated signaling pathwayGO:07009810.0CCL2, CCR5, CCR1
8negative regulation of hormone secretionGO:04688810.0EDN1, IL6
9monocyte chemotaxisGO:00254810.0CCL2, IL6
10MAPK import into nucleusGO:00018910.0MAPK1, FGF2
11positive regulation of T cell activationGO:0508709.9THY1, CCL2
12calcium-mediated signalingGO:0197229.9AGTR1, CCR5, EDN1
13regulation of angiogenesisGO:0457659.9FGF2, IL6
14B cell receptor signaling pathwayGO:0508539.8CD79A, MAPK1
15lipopolysaccharide-mediated signaling pathwayGO:0316639.8MAPK1, CCL2
16cell migration involved in sprouting angiogenesisGO:0020429.8VEGFA, FGF2
17vascular endothelial growth factor receptor signaling pathwayGO:0480109.8CCL2, VEGFA
18positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, FGF2
19positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGF2, IL6, CCR1
20response to amino acidGO:0432009.7IL6, CCL2, EDN1
21positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, EDN1
22positive regulation of cytosolic calcium ion concentrationGO:0072049.7EDN1, CCR5, CCR1, AGTR1
23MAPK cascadeGO:0001659.7MAPK1, CCR5, CCL2
24response to antibioticGO:0466779.7IL6, CCL2
25positive chemotaxisGO:0509189.7VEGFA, FGF2
26cell surface receptor signaling pathwayGO:0071669.6CCR1, CCR5, CCL2, EDN1
27organ morphogenesisGO:0098879.6FGF2, MAPK1, CCL2
28cell-cell signalingGO:0072679.6CCR1, CCR5, EDN1
29G-protein coupled receptor signaling pathwayGO:0071869.6AGTR1, CCR5, CCL2, EDN1
30positive regulation of cell divisionGO:0517819.5FGF2, PDGFD, VEGFA
31inflammatory responseGO:0069549.5CCL2, CCR5, CCR1, IL6
32positive regulation of endothelial cell proliferationGO:0019389.5VEGFA, CCL2, FGF2
33cellular response to interleukin-1GO:0713479.5CCL2, EDN1
34regulation of cell shapeGO:0083609.4IL6, CCL2, VEGFA
35response to hypoxiaGO:0016669.4EDN1, VEGFA, CCL2
36cytokine-mediated signaling pathwayGO:0192219.3CCL2, CCR1, IL6
37positive regulation of cell migrationGO:0303359.3EDN1, VEGFA, MAPK1
38response to heatGO:0094089.3TGFB1I1, CCL2, IL6
39angiogenesisGO:0015259.2CCL2, VEGFA, THY1
40chemotaxisGO:0069359.1FGF2, MAPK1, CCR1, CCR5, CCL2
41platelet activationGO:0301689.0VEGFA, IL6, MAPK1
42positive regulation of transcription, DNA-templatedGO:0458938.5FGF2, MAPK1, IL6, TGFB1I1
43positive regulation of cell proliferationGO:0082848.5EDN1, VEGFA, IL6, MAPK1, FGF2

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:07179110.2CCR1, CCR5
2C-C chemokine bindingGO:01995710.1CCR1, CCR5
3C-C chemokine receptor activityGO:01649310.0CCR5, CCR1
4phosphatidylinositol phospholipase C activityGO:0044359.9CCR1, CCR5
5chemokine receptor activityGO:0049509.8CCR1, CCR5
6platelet-derived growth factor receptor bindingGO:0051619.6PDGFD, VEGFA
7chemoattractant activityGO:0420569.1FGF2, VEGFA
8heparin bindingGO:0082019.1VEGFA, CCL2, FGF2
9growth factor activityGO:0080838.9FGF2, PDGFD, IL6, VEGFA
10cytokine activityGO:0051258.8EDN1, VEGFA, IL6, FGF2
11protein bindingGO:0055156.1EDN1, THY1, VEGFA, TGFB1I1, CCR5, CCR1

Products for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Sources for Mesangial Proliferative Glomerulonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet