MCID: MSN001
MIFTS: 46

Mesangial Proliferative Glomerulonephritis malady

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

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Aliases & Descriptions for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 10 45 12 65
Glomerulonephritis - Mesangial Proliferative 45
 
Glomerulonephritis Mesangial Proliferative 47
Mesangial Proliferative Gn 45

Classifications:



External Ids:

Disease Ontology10 DOID:4783
SNOMED-CT59 35546006
NCIt42 C35445
UMLS65 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

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Wikipedia:68 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

MalaCards based summary: Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to glomerulonephritis and proliferative glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and TNF signaling pathway. Affiliated tissues include lung, prostate and colon, and related mouse phenotypes are renal/urinary system and cellular.

Related Diseases for Mesangial Proliferative Glomerulonephritis

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Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis11.0
2proliferative glomerulonephritis11.0
3mammary paget's disease10.6FGF2, IL6
4congenital dyserythropoietic anemia10.6CCL2, IL6
5residual stage angle-closure glaucoma10.6FGF2, IL6
6intermediate dend syndrome10.6EDN1, IL6
7crohn's disease10.6EDN1, IL6
8eccrine sweat gland neoplasm10.6CCL2, IL6
9childhood kidney cell carcinoma10.6CCL2, IL6
10dyskinesia of esophagus10.5CCL2, IL6
11non-langerhans-cell histiocytosis10.5CCL2, CCR5
12secretory diarrhea10.5CCL2, IL6
13amusia10.5CCR5, IL6
14gestational diabetes10.4CCL2, EDN1
15c1q deficiency10.4
16sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.4
17familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.4
18idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation10.4
19nephrotic syndrome10.4
20brain ischemia10.4EDN1, IL6
21placental abruption10.4CCR5, IL6
22hypopharynx cancer10.4CCR5, IL6
23plasmacytoma10.4CD79A, IL6
24tracheal stenosis10.4EDN1, IL6
25plasma protein metabolism disease10.4CD79A, IL6
26glomus tympanicum tumor10.3CCL2, CD79A
27protein-energy malnutrition10.3FGF2, IL6
28collagenous colitis10.3CD79A, IL6
29intestinal impaction10.3CD79A, IL6
30granulomatous amebic encephalitis10.3CD79A, IL6
31refractory plasma cell neoplasm10.3CD79A, IL6
32optic neuritis10.3CD79A, IL6
33cerebellopontine angle primitive neuroectodermal10.3CCR1, CCR5
34crescentic glomerulonephritis10.3CCL2, CD79A
35pyrimidine metabolic disorder10.3CCL2, IL6
36subacute glomerulonephritis10.3CD79A, FGF2
37narcissistic personality disorder10.3CD79A, IL6
38foveal hypoplasia 110.3CCL2, FGF2, IL6
39scrotum squamous cell carcinoma10.3CD79A, IL6
40diffuse intraductal papillomatosis10.3CD79A, IL6
41blue toe syndrome10.3CD79A, IL6
42acute diffuse nephritis10.3CD79A, EDN1
43lateral sclerosis10.3CCL2, IL6
44cystic echinococcosis10.2CD79A, IL6
45gingival overgrowth10.2CCL2, EDN1, IL6
46overnutrition10.2CD79A, IL6
47colonic benign neoplasm10.2CCL2, EDN1, IL6
48pericardium disease10.2CCL2, EDN1, IL6
49hepatitis10.2
50suppurative uveitis10.2CCL2, CCR5

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to mesangial proliferative glomerulonephritis

Symptoms for Mesangial Proliferative Glomerulonephritis

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Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

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Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Calcitriolapproved, nutraceuticalPhase 416132222-06-3134070, 5280453
Synonyms:
(1R,3S)-5-{2-[(1R,3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
(1S,3R,5Z,7e)-9,10-Secocholesta-5,7,10-triene-1,3,25-triol
(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(1alpha,3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol
(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol
(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol
(5Z,7e)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
1 alpha,25-Dihydroxyvitamin D3
1,25 (OH)2 D3
1,25 Dihydroxycholecalciferol
1,25(OH)2-20epi-D3
1,25(OH)2D3 & CD4
1,25(OH2)D3
1,25-(OH)2-D3
1,25-(OH)2D3
1,25-DHCC
1,25-DIHYDROXYCHOLECALCIFEROL
1,25-Dihydroxycholecalciferol
1,25-Dihydroxycholecaliferol
1,25-Dihydroxyvitamin D
1,25-Dihydroxyvitamin D3
1,25-dihydroxy vitamin D3
1,25-dihydroxy-20-epi-Vitamin D3
1,25-dihydroxycholecalciferol
1,25D3
1-alpha,-1,25-Dihydroxyvitamin D3
1-alpha,25-Dihydroxycholecalciferol
1-alpha,25-Dihydroxyvitamin D3
1-alpha-25-Dihydroxyvitamin D3
1-alpha-25-dihydroxyvitamin D3
1.Alpha.,25-Dihydroxy-26,27-hexadeuterovitamin D3
17936_FLUKA
17936_SIGMA
1a,25-(OH)2D3
1a,25-Dihydroxycholecalciferol
1a,25-Dihydroxyvitamin D3
1alpha,25(OH)2-D3
1alpha,25(OH)2D3
1alpha,25-Dihydroxycholecalciferol
1alpha,25-Dihydroxyvitamin D
1alpha,25-Dihydroxyvitamin D3
1db1
1α,25(OH)2D3
1α,25-dihydroxycholecalciferol
1α,25-dihydroxyvitamin D3
20-epi-1alpha,25-dihydroxycholecaliferol
25-Dihydroxycholecalciferol
32222-06-3
5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1.alpha.,3.beta,.5Z,7E)- & CD4
9,10-seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha, 3beta, 25-triol
AC-1859
AC1NQX1S
 
Ambap32222-06-3
Asentar
BCBcMAP01_000160
BML2-E03
BSPBio_001287
C01673
CCRIS 5522
CD-2027
CHEBI:17823
CHEMBL846
CID5280453
CPD000466393
Calcijex
Calcijex, Silkis, Rocaltrol, Topitriol, Cholecalciferol,Calcitriol
Calcitriol
Calcitriol (JAN/USAN/INN)
Calcitriol [USAN:INN:BAN:JAN]
Calcitriolum
Calcitriolum [INN-Latin]
D00129
D1530_SIGMA
DN 101
DN-101
Decostriol
Dihydroxyvitamin D3
EINECS 250-963-8
HMS1361A09
HMS1791A09
HMS1989A09
HMS2051F06
HMS2089N03
HSDB 3482
IDI1_033757
LMST03020258
LS-53093
MC-1288
MC1288
MLS000759536
MLS001424122
MolPort-002-045-698
NCGC00161327-01
NCGC00161327-04
Ro 21-5535
Ro 215535
Ro-21-5535
Rocaltrol
Rocaltrol (TN)
S1466_Selleck
SAM001246772
SMR000466393
Silkis
Soltriol
Spectrum5_002061
Topitriol
Toptriol
U 49562
Vectical
ZINC03924790
calcitriol
vit D
2MicronutrientsPhase 4, Phase 33901
3Trace ElementsPhase 4, Phase 33900
4Vasoconstrictor AgentsPhase 41303
5Immunologic FactorsPhase 4, Phase 318483
6VitaminsPhase 4, Phase 33857
7ImmunoglobulinsPhase 4, Phase 34477
8Bone Density Conservation AgentsPhase 4, Phase 32600
9Calcium, DietaryPhase 44678
10Immunoglobulin APhase 4, Phase 3110
11AntibodiesPhase 4, Phase 34477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Calcitriol in the Treatment of Immunoglobulin A (IgA) NephropathyCompletedNCT00319761Phase 4
2Calcitriol in the Treatment of Immunoglobulin A NephropathyRecruitingNCT00862693Phase 4
3Paricalcitol for the Treatment of Immunoglobulin A NephropathyWithdrawnNCT00599963Phase 3

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

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Anatomical Context for Mesangial Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

33
Lung, Prostate, Colon, Breast, Pituitary, B cells, Thyroid

Animal Models for Mesangial Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6CCR1, CD79A, EDN1, GAS6, IL6
2MP:00053847.6AXL, CCR1, CCR5, CD79A, FGF2, GAS6
3MP:00053977.4AXL, CCR1, CCR5, CD79A, FGF2, GAS6
4MP:00053857.2AXL, CCR1, CCR5, EDN1, FGF2, GAS6
5MP:00053877.1AXL, CCL2, CCR1, CCR5, CD79A, GAS6
6MP:00053767.0AXL, CCR1, CCR5, CD79A, EDN1, FGF2

Publications for Mesangial Proliferative Glomerulonephritis

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Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. (25932265)
2015
2
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. (24701045)
2014
3
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. (24858931)
2014
4
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
5
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. (24649023)
2013
6
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. (22607047)
2012
7
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. (21349934)
2011
8
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
9
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. (17717029)
2007
10
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
11
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
12
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. (15947989)
2005
13
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
14
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
15
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. (12375274)
2002
16
Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. (12028445)
2002
17
PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. (11260393)
2001
18
Morphometric comparison of the quantity of the mesangial deposits in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (11518047)
2001
19
Localization in situ of type VI collagen protein and its mRNA in mesangial proliferative glomerulonephritis using renal biopsy sections. (9930877)
1999
20
Experimental mesangial proliferative glomerulonephritis (the anti-Thy-1.1 model). (10630692)
1999
21
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. (9809476)
1998
22
Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis. (9727007)
1998
23
Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. (9808091)
1998
24
Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis. (9773782)
1998
25
Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. (8651905)
1996
26
Mesangial proliferative glomerulonephritis and nephrotic syndrome with hepatitis A virus infection. (9141810)
1996
27
Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. (8755633)
1996
28
The novel regulatory mechanism of Fas system-mediated apoptosis in mesangial cells: implication to mesangial proliferative glomerulonephritis. (8619833)
1996
29
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
30
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
31
Mononuclear cell subsets in IgM mesangial proliferative glomerulonephritis. A comparative study with minimal change nephrotic syndrome and immunonegative mesangial proliferative glomerulonephritis. (8247183)
1993
32
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
33
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
34
IgM-associated primary diffuse mesangial proliferative glomerulonephritis: natural history and prognostic indicators. (1852859)
1991
35
Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition. (2044226)
1991
36
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
37
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
38
Mesangial proliferative glomerulonephritis in a patient with hepatic hydatid cysts: a case report in an African male. (3232184)
1988
39
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
40
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
41
Mesangial proliferative glomerulonephritis with Legionnaires' disease. A case report. (3983750)
1985
42
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
43
Mesangial proliferative glomerulonephritis with IgM deposits. Clinicopathologic analysis and evidence for morphologic transitions. (6382035)
1984
44
Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. (6188567)
1983
45
Long term study of mesangial proliferative glomerulonephritis with IgM deposits. (7329978)
1981
46
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
47
Mesangial proliferative glomerulonephritis with irregular intramembranous deposits. Another variant of hypocoplementemic nephritis. (331950)
1977
48
Mesangial proliferative glomerulonephritis in childhood. (4536432)
1973
49
50

Variations for Mesangial Proliferative Glomerulonephritis

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Expression for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.5CD79A, FGF2, IL6
29.4CCL2, EDN1, IL6
39.4CCL2, EDN1, IL6
49.3CCR1, CD79A, IL6
5
Show member pathways
9.2CCL2, CCR1, CCR5
6
Show member pathways
8.5FGF2, GAS6, IL6, PDGFD
7
Show member pathways
8.1CD79A, FGF2, GAS6, IL6, PDGFD
8
Show member pathways
7.8AXL, FGF2, GAS6, IL6, PDGFD
9
Show member pathways
7.5AXL, CD79A, FGF2, GAS6, IL6, PDGFD
10
Show member pathways
7.5AXL, CCL2, FGF2, GAS6, IL6, PDGFD
11
Show member pathways
7.5AXL, CCL2, FGF2, GAS6, IL6, PDGFD
12
Show member pathways
7.1CCL2, CCR1, CCR5, FGF2, GAS6, IL6
13
Show member pathways
6.5AXL, CCL2, CCR1, CCR5, FGF2, GAS6
14
Show member pathways
6.5AXL, CCL2, CCR1, CCR5, FGF2, GAS6

GO Terms for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:004667710.5CCL2, IL6
2positive regulation of nitric oxide biosynthetic processGO:004542910.4EDN1, IL6
3positive regulation of endothelial cell migrationGO:001059510.3EDN1, FGF2
4maternal process involved in parturitionGO:006013710.3CCL2, EDN1
5negative regulation of hormone secretionGO:004688810.3EDN1, IL6
6regulation of angiogenesisGO:004576510.3FGF2, IL6
7response to amino acidGO:004320010.3EDN1, IL6
8cellular response to drugGO:003569010.2CCL2, EDN1
9cell growthGO:001604910.2EDN1, IL6
10viral genome replicationGO:001907910.2CCL2, GAS6
11response to bacteriumGO:000961710.2CCL2, IL6
12organ regenerationGO:003110010.1CCL2, GAS6
13positive regulation of monocyte chemotaxisGO:009002610.1CCL2, CCR1
14cellular response to interferon-gammaGO:007134610.0CCL2, EDN1
15cellular response to dexamethasone stimulusGO:007154910.0CCL2, IL6
16apoptotic cell clearanceGO:004327710.0AXL, GAS6
17negative regulation of dendritic cell apoptotic processGO:200066910.0AXL, GAS6
18chemokine-mediated signaling pathwayGO:00700989.9CCL2, CCR5
19negative regulation of interferon-gamma productionGO:00326899.9AXL, GAS6
20positive regulation of natural killer cell differentiationGO:00328259.9AXL, GAS6
21viral entry into host cellGO:00467189.8CCR5, GAS6
22dendritic cell differentiationGO:00970289.8AXL, GAS6
23cytokine-mediated signaling pathwayGO:00192219.8CCL2, CCR1, IL6
24cellular response to interleukin-1GO:00713479.8CCL2, EDN1, IL6
25positive regulation of cell divisionGO:00517819.8FGF2, PDGFD
26response to woundingGO:00096119.8CCL2, CCR1, IL6
27cellular response to transforming growth factor beta stimulusGO:00715609.8EDN1, PDGFD
28positive regulation of protein kinase B signalingGO:00518979.7FGF2, GAS6, IL6
29enzyme linked receptor protein signaling pathwayGO:00071679.7AXL, GAS6
30phagocytosisGO:00069099.7AXL, GAS6
31MAPK cascadeGO:00001659.6CCL2, CCR5, FGF2
32response to heatGO:00094089.5CCL2, IL6
33positive regulation of MAP kinase activityGO:00434069.4EDN1, FGF2, PDGFD
34immune responseGO:00069559.4CCL2, CCR1, IL6
35chemotaxisGO:00069359.3CCL2, CCR1, FGF2
36cell-cell signalingGO:00072679.3CCR1, CCR5, EDN1
37positive regulation of gene expressionGO:00106289.3FGF2, GAS6, IL6
38cellular response to lipopolysaccharideGO:00712229.2AXL, CCL2, IL6
39positive regulation of smooth muscle cell proliferationGO:00486619.0EDN1, FGF2, IL6, PDGFD
40positive regulation of ERK1 and ERK2 cascadeGO:00703748.8CCL2, CCR1, FGF2, GAS6, IL6

Sources for Mesangial Proliferative Glomerulonephritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet