MCID: MSN001
MIFTS: 43

Mesangial Proliferative Glomerulonephritis malady

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

Aliases & Descriptions for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 12 50 14 69
Glomerulonephritis - Mesangial Proliferative 50
Glomerulonephritis Mesangial Proliferative 52
Mesangial Proliferative Gn 50

Classifications:



External Ids:

Disease Ontology 12 DOID:4783
NCIt 47 C35445
SNOMED-CT 64 35546006
UMLS 69 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

MalaCards based summary : Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to c1q deficiency and glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Calcitriol and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and monocytes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

Related Diseases for Mesangial Proliferative Glomerulonephritis

Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 c1q deficiency 11.3
2 glomerulonephritis 10.9
3 proliferative glomerulonephritis 10.9
4 nephrotic syndrome 10.3
5 glomerulosclerosis, focal segmental, 4 10.3
6 focal segmental glomerulosclerosis 10.3
7 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.3
8 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.3
9 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 10.3
10 anal paget's disease 10.2 FGF2 IL6
11 schwannoma of ureter 10.2 CCL2 IL6
12 bipolar i disorder 10.2 FGF2 IL6
13 neuroaxonal dystrophy 10.2 CCL2 IL6
14 esophagus lymphoma 10.2 EDN1 IL6
15 generalized atherosclerosis 10.1 CD79A IL6
16 pyriform sinus cancer 10.1 CCL2 FGF2 IL6
17 optic nerve hypoplasia 10.1 CCL2 FGF2 IL6
18 hepatitis 10.1
19 central nervous system lymphoma 10.1 CCL2 EDN1 IL6
20 nervous system cancer 10.1 CCL2 EDN1 IL6
21 myelophthisic anemia 10.1 CCL2 EDN1 IL6
22 blackwater fever 10.1 CD79A EDN1
23 clostridium difficile colitis 10.1 CD79A IL6
24 subcorneal pustular dermatosis 10.0 CCL2 EDN1 IL6
25 measles 10.0 IL6 MAPK1
26 angiokeratoma 10.0 CD79A FGF2
27 pyrimidine metabolic disorder 10.0 CCL2 EDN1 IL6
28 lateral cystocele 10.0 CCL2 CD79A IL6
29 immune-complex glomerulonephritis 10.0 CCL2 CD79A IL6
30 interstitial nephritis 10.0
31 polymyositis 10.0
32 breast apocrine carcinoma in situ 10.0 CCL2 CD79A IL6
33 bone angioendothelial sarcoma 10.0 CCL2 CD79A IL6
34 acute chest syndrome 10.0 CCL2 CD79A IL6
35 paranasal sinus sarcoma 10.0 CD79A EDN1 IL6
36 oppositional defiant disorder 10.0 CCL2 EDN1 FGF2 IL6
37 autoimmune-related retinopathy and optic neuropathy 9.9 CCL2 EDN1 IL6
38 chronic mucocutaneous candidiasis 9.9 CD79A GAS6
39 advanced sleep phase syndrome, familial, 1 9.9 CCL2 CCR1 IL6
40 uveitis 9.9 CCL2 CD79A
41 malaria 9.8
42 hepatitis c virus 9.8
43 leprosy 9.8
44 multiple myeloma 9.8
45 pityriasis rubra pilaris 9.8
46 arthritis 9.8
47 myasthenia gravis 9.8
48 hepatitis a 9.8
49 hemolytic-uremic syndrome 9.8
50 hellp syndrome 9.8

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to Mesangial Proliferative Glomerulonephritis

Symptoms & Phenotypes for Mesangial Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 AXL CCR1 EDN1 FGF2 GAS6 IL6
2 hematopoietic system MP:0005397 9.87 IL6 MAPK1 AXL CCR1 CD79A FGF2
3 homeostasis/metabolism MP:0005376 9.86 AXL CCR1 CD79A EDN1 FGF2 GAS6
4 immune system MP:0005387 9.7 AXL CCL2 CCR1 CD79A GAS6 IL6
5 liver/biliary system MP:0005370 9.35 AXL CCR1 CD79A IL6 MAPK1
6 renal/urinary system MP:0005367 9.02 CCR1 CD79A EDN1 GAS6 IL6

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
2 Trace Elements Phase 4,Phase 3
3 Vasoconstrictor Agents Phase 4
4 Vitamins Phase 4,Phase 3
5 Immunoglobulin A Phase 4,Phase 3
6 Immunoglobulins Phase 4,Phase 3
7 Antibodies Phase 4,Phase 3
8 Micronutrients Phase 4,Phase 3
9 Bone Density Conservation Agents Phase 4,Phase 3
10 Calcium, Dietary Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4
2 Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy Completed NCT00319761 Phase 4
3 Paricalcitol for the Treatment of Immunoglobulin A Nephropathy Withdrawn NCT00599963 Phase 3

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

39
Lung, T Cells, Monocytes, Endothelial, Kidney, Brain

Publications for Mesangial Proliferative Glomerulonephritis

Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50) (show all 142)
id Title Authors Year
1
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
2
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
3
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
4
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
5
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
6
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
7
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
8
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. ( 24649023 )
2013
9
Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report. ( 22261745 )
2013
10
Efficacy of antisense monocyte chemoattractant protein-1 (MCP-1) in a rat model of mesangial proliferative glomerulonephritis. ( 23991758 )
2013
11
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
12
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. ( 22641568 )
2013
13
Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. ( 22576627 )
2012
14
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. ( 22607047 )
2012
15
Successful treatment of a mesangial proliferative glomerulonephritis with interstitial nephritis associated with Castleman's disease by an anti-interleukin-6 receptor antibody (tocilizumab). ( 22687845 )
2012
16
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis. ( 22286178 )
2012
17
Protein kinase C I^ inhibition ameliorates experimental mesangial proliferative glomerulonephritis. ( 21575103 )
2011
18
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. ( 21349934 )
2011
19
Primary SjAPgren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child. ( 19902265 )
2010
20
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. ( 20110667 )
2010
21
Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. ( 20030533 )
2009
22
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. ( 19617668 )
2009
23
The relation of IgM deposition to clinical parameters and histomorphometry in childhood mesangial proliferative glomerulonephritis. ( 18093746 )
2008
24
Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis. ( 18497456 )
2008
25
Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. ( 18480612 )
2008
26
Mesangial proliferative glomerulonephritis with or without IgA deposits: the morphological characters in psoriasis vulgaris. ( 18332636 )
2008
27
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. ( 17717029 )
2007
28
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. ( 16541204 )
2007
29
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. ( 15917985 )
2006
30
The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. ( 16179805 )
2006
31
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. ( 16807544 )
2006
32
Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. ( 16860199 )
2006
33
Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature. ( 15971069 )
2005
34
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. ( 16092667 )
2005
35
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. ( 16247710 )
2005
36
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. ( 16334979 )
2005
37
All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. ( 15795517 )
2005
38
Effect of lipo-prostaglandin E1 on mesangial proliferative glomerulonephritis in rats. ( 16463661 )
2005
39
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. ( 15947989 )
2005
40
Gene expression profile in experimental mesangial proliferative glomerulonephritis. ( 15351794 )
2004
41
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. ( 17642763 )
2004
42
[Mesangial proliferative glomerulonephritis]. ( 15500128 )
2004
43
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. ( 14600028 )
2003
44
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. ( 11979343 )
2002
45
Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. ( 12028445 )
2002
46
Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. ( 11982588 )
2002
47
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. ( 12371966 )
2002
48
Mesangial proliferative glomerulonephritis triggered by spleno-renal shunt in a cirrhotic patient. ( 12038661 )
2002
49
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. ( 12375274 )
2002
50
PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. ( 11260393 )
2001

Variations for Mesangial Proliferative Glomerulonephritis

Expression for Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for Mesangial Proliferative Glomerulonephritis

Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 AXL CCL2 CCR1 FGF2 GAS6 IL6
2
Show member pathways
13.5 AXL CD79A FGF2 GAS6 IL6 MAPK1
3
Show member pathways
13.45 AXL CCL2 CCR1 EDN1 IL6 MAPK1
4
Show member pathways
13.35 AXL FGF2 GAS6 IL6 MAPK1 PDGFD
5
Show member pathways
13.29 AXL CCL2 FGF2 GAS6 IL6 MAPK1
6
Show member pathways
13.17 CCL2 CCR1 FGF2 IL6 MAPK1
7
Show member pathways
13.17 AXL CCL2 CCR1 FGF2 GAS6 IL6
8
Show member pathways
13.05 AXL FGF2 GAS6 IL6 MAPK1 PDGFD
9
Show member pathways
12.99 AXL CD79A FGF2 GAS6 IL6 MAPK1
10
Show member pathways
12.87 CCL2 CCR1 FGF2 GAS6 IL6 MAPK1
11
Show member pathways
12.82 CD79A FGF2 GAS6 IL6 MAPK1 PDGFD
12
Show member pathways
12.77 AXL FGF2 GAS6 IL6 MAPK1 PDGFD
13
Show member pathways
12.53 FGF2 GAS6 IL6 PDGFD
14 12.41 FGF2 IL6 MAPK1 PDGFD
15
Show member pathways
12.39 CCL2 FGF2 IL6 MAPK1
16
Show member pathways
12.16 CCL2 IL6 MAPK1
17
Show member pathways
12.05 AXL CCL2 FGF2 GAS6 IL6 MAPK1
18
Show member pathways
12 EDN1 FGF2 MAPK1
19 11.86 CCL2 IL6 MAPK1
20 11.84 CCR1 CD79A IL6
21 11.82 CCL2 FGF2 IL6
22 11.74 EDN1 IL6 MAPK1
23 11.71 CD79A FGF2 IL6
24 11.66 CCL2 EDN1 IL6 MAPK1
25 11.49 FGF2 GAS6 IL6 MAPK1 PDGFD
26 11.45 CCL2 EDN1 IL6 MAPK1
27 11.36 CCL2 CCR1 IL6
28 11.21 IL6 MAPK1
29 11.19 EDN1 MAPK1
30 11.19 CCL2 IL6
31 11.17 IL6 MAPK1
32
Show member pathways
11.12 EDN1 MAPK1
33 11.06 CCL2 EDN1 FGF2 IL6
34 11.03 EDN1 MAPK1
35 11.01 FGF2 MAPK1

GO Terms for Mesangial Proliferative Glomerulonephritis

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL2 EDN1 FGF2 GAS6 IL6 MAPK1
2 extracellular space GO:0005615 9.17 AXL CCL2 EDN1 FGF2 GAS6 IL6

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 46)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.94 AXL CCL2 CCR1 IL6
2 cell surface receptor signaling pathway GO:0007166 9.86 CCL2 CCR1 CD79A EDN1
3 positive regulation of cell proliferation GO:0008284 9.85 EDN1 FGF2 IL6 MAPK1 PDGFD
4 cytokine-mediated signaling pathway GO:0019221 9.84 CCL2 CCR1 IL6
5 cellular response to lipopolysaccharide GO:0071222 9.83 AXL CCL2 IL6
6 animal organ morphogenesis GO:0009887 9.82 CCL2 FGF2 MAPK1
7 cellular response to tumor necrosis factor GO:0071356 9.82 CCL2 EDN1 IL6
8 positive regulation of protein kinase B signaling GO:0051897 9.78 AXL GAS6 IL6
9 response to wounding GO:0009611 9.76 CCL2 CCR1 IL6
10 cellular response to interleukin-1 GO:0071347 9.75 CCL2 EDN1 IL6
11 response to lipopolysaccharide GO:0032496 9.73 CCL2 EDN1 IL6 MAPK1
12 cellular response to drug GO:0035690 9.72 CCL2 EDN1 GAS6
13 cellular response to dexamethasone stimulus GO:0071549 9.7 CCL2 IL6
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 EDN1 IL6 PDGFD
15 response to bacterium GO:0009617 9.69 CCL2 IL6
16 response to antibiotic GO:0046677 9.69 CCL2 IL6
17 regulation of angiogenesis GO:0045765 9.69 FGF2 IL6
18 cellular response to hydrogen peroxide GO:0070301 9.69 AXL IL6 PDGFD
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 CCL2 MAPK1
20 negative regulation of interferon-gamma production GO:0032689 9.68 AXL GAS6
21 cellular response to fatty acid GO:0071398 9.68 CCL2 EDN1
22 neural crest cell development GO:0014032 9.67 EDN1 MAPK1
23 cellular response to platelet-derived growth factor stimulus GO:0036120 9.67 CCL2 PDGFD
24 positive regulation of MAP kinase activity GO:0043406 9.67 EDN1 FGF2 PDGFD
25 positive regulation of cell migration GO:0030335 9.67 CCR1 EDN1 MAPK1 PDGFD
26 positive regulation of monocyte chemotaxis GO:0090026 9.66 CCL2 CCR1
27 apoptotic cell clearance GO:0043277 9.66 AXL GAS6
28 viral genome replication GO:0019079 9.65 CCL2 GAS6
29 animal organ regeneration GO:0031100 9.65 AXL CCL2 GAS6
30 dendritic cell differentiation GO:0097028 9.63 AXL GAS6
31 positive regulation of protein import into nucleus, translocation GO:0033160 9.63 IL6 MAPK1
32 enzyme linked receptor protein signaling pathway GO:0007167 9.62 AXL GAS6
33 negative regulation of hormone secretion GO:0046888 9.62 EDN1 IL6
34 maternal process involved in parturition GO:0060137 9.61 CCL2 EDN1
35 positive regulation of natural killer cell differentiation GO:0032825 9.6 AXL GAS6
36 cellular response to interferon-alpha GO:0035457 9.59 AXL GAS6
37 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.57 AXL GAS6
38 chemotaxis GO:0006935 9.56 CCL2 CCR1 FGF2 MAPK1
39 regulation of vascular endothelial growth factor production GO:0010574 9.54 CCL2 IL6
40 response to amino acid GO:0043200 9.5 CCL2 EDN1 IL6
41 negative regulation of dendritic cell apoptotic process GO:2000669 9.4 AXL GAS6
42 protein kinase B signaling GO:0043491 9.33 AXL CCL2 GAS6
43 platelet activation GO:0030168 9.26 AXL GAS6 IL6 MAPK1
44 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.1 CCL2 CCR1 FGF2 GAS6 IL6 PDGFD
45 signal transduction GO:0007165 10.16 AXL CCL2 CCR1 FGF2 GAS6 MAPK1
46 protein phosphorylation GO:0006468 10 AXL CCL2 GAS6 MAPK1

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 FGF2 IL6 PDGFD
2 receptor binding GO:0005102 9.26 CCL2 EDN1 GAS6 IL6
3 cytokine activity GO:0005125 8.92 CCL2 EDN1 FGF2 IL6

Sources for Mesangial Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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