MCID: MSN001
MIFTS: 49

Mesangial Proliferative Glomerulonephritis malady

Summaries for Mesangial Proliferative Glomerulonephritis

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64Wikipedia, 33MalaCards
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Wikipedia:64 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

MalaCards: Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to proliferative glomerulonephritis and nephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are p70S6K Signaling and TGF-Beta Pathway. The compounds estrogen and suramin have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and monocytes, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

mesangial proliferative glomerulonephritis 8 43 61
glomerulonephritis - mesangial proliferative 43
glomerulonephritis mesangial proliferative 45
mesangial proliferative gn 43
increased mesangial matrix 61


External Ids:

Disease Ontology8 DOID:4783
SNOMED-CT57 35546006
NCIt40 C35445

Related Diseases for Mesangial Proliferative Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative glomerulonephritis32.0CD79A, CCL2
2nephritis30.6CCL2, CD79A, THY1
3polymyositis30.6CCR5
4acute poststreptococcal glomerulonephritis30.4CD79A
5hepatitis c30.4CCR5
6pulmonary disease, chronic obstructive30.3IL6, CCL2, CCR5
7iga glomerulonephritis30.3CCR5, CCL2, AGTR1, CD79A, IL6
8arthritis30.3CCR5, CCL2, CCR1, AGTR1, FGF2, IL6
9n syndrome10.7
10acute proliferative glomerulonephritis10.6
11familial mediterranean fever10.4
12hellp syndrome10.3
13cryoglobulinemia10.3
14hepatitis e10.3
15mixed connective tissue disease10.3
16immune-complex glomerulonephritis10.3
17small cell carcinoma10.3
18legionnaires' disease10.3
19urticaria10.3
20castleman's disease10.3
21steroid-resistant nephrotic syndrome10.3
22c1q deficiency10.3
23hepatitis c virus10.3
24pertussis10.0CD79A
25purpura10.0CD79A
26sinusitis10.0CD79A
27dermatitis10.0CD79A
28prostatitis10.0CD79A
29thyroiditis10.0CD79A
30atopy10.0CD79A
31neuropathy10.0CD79A
32ankylosing spondylitis10.0CD79A
33nephrotic syndrome10.0CD79A
34herpes simplex10.0CD79A
35hyperglycemia10.0AGTR1
36rhinitis10.0CD79A
37acute leukemia10.0THY1
38reactive arthritis10.0CD79A
39tonsillitis10.0CD79A
40hepatitis b10.0CD79A
41human immunodeficiency virus infectious disease10.0CD79A
42conjunctivitis10.0CD79A
43celiac disease10.0CD79A
44infertility10.0CD79A
45vesicoureteral reflux10.0AGTR1
46lupus erythematosus10.0CD79A
47graves' disease10.0CCR5
48tetanus10.0CD79A
49polyneuropathy10.0CD79A
50sarcoma10.0THY1

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to mesangial proliferative glomerulonephritis

Clinical Features for Mesangial Proliferative Glomerulonephritis

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

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33MalaCards
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MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

33
Brain, Lung, Monocytes, T cells, Endothelial

Animal Models for Mesangial Proliferative Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mesangial Proliferative Glomerulonephritis

Sources:
51PubMed
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Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report. (22261745)
2013
2
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. (22607047)
2012
3
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis. (22286178)
2012
4
Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. (22576627)
2012
5
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. (21349934)
2011
6
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. (20110667)
2010
7
Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. (16860199)
2006
8
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
9
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. (15947989)
2005
10
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. (14600028)
2003
11
Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. (11982588)
2002
12
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. (12371966)
2002
13
Ambulatory blood pressure in patients with mesangial proliferative glomerulonephritis. (11688762)
2001
14
Caveolae in mesangial cells and caveolin expression in mesangial proliferative glomerulonephritis. (11168929)
2001
15
Mesangial proliferative glomerulonephritis with deposits of anti-nicotinic acetylcholine receptor antibody in a patient with myasthenia gravis. (11535018)
2001
16
Mesangial proliferative glomerulonephritis with predominant mesangial IgG deposition in renal allograft. (11096326)
2000
17
Role of matrix metalloproteinases in mesangial proliferative glomerulonephritis. (11031721)
2000
18
The effect of combination therapy with interferon and cryofiltration on mesangial proliferative glomerulonephritis originating from mixed cryoglobulinemia in chronic hepatitis C virus infection. (10608730)
1999
19
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. (9809476)
1998
20
Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis. (9773782)
1998
21
Mesangial proliferative glomerulonephritis in chronic obstructive pulmonary disease. (10218320)
1998
22
Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. (9848780)
1998
23
Role of thrombin in mesangial proliferative glomerulonephritis. (9844159)
1998
24
C3 mesangial proliferative glomerulonephritis--an evaluation of acute poststreptococcal glomerulonephritis? (9518184)
1997
25
Mesangial proliferative glomerulonephritis and nephrotic syndrome with hepatitis A virus infection. (9141810)
1996
26
Sequential expression of cellular fibronectin by platelets, macrophages, and mesangial cells in proliferative glomerulonephritis. (8080041)
1994
27
Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis. (8468929)
1993
28
Rat glomerular mesangial cells synthesize basic fibroblast growth factor. Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis. (1361494)
1992
29
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
30
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
31
Kynurenine and mesangial-proliferative glomerulonephritis. (1772101)
1991
32
Mesangial proliferative glomerulonephritis in southwestern American Indians. (2609403)
1989
33
Mesangial proliferative glomerulonephritis in a patient with hepatic hydatid cysts: a case report in an African male. (3232184)
1988
34
Pregnancy in women with diffuse mesangial proliferative glomerulonephritis. (3365864)
1988
35
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
36
IgM-associated mesangial proliferative glomerulonephritis and focal and segmental hyalinosis with nephrotic syndrome. (4083317)
1985
37
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
38
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
39
Mesangial proliferative glomerulonephritis with IgM deposits. Clinicopathologic analysis and evidence for morphologic transitions. (6382035)
1984
40
Acute renal failure and tubular necrosis associated with hematuria due to mesangial proliferative glomerulonephritis. (6525773)
1984
41
Proliferative glomerulonephritis in rats: evidence that mononuclear phagocytes infiltrating the glomeruli stimulate the proliferation of endothelial and mesangial cells. (6785101)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Mesangial proliferative glomerulonephritis in children. (452892)
1979
44
Mesangial proliferative glomerulonephritis. (355724)
1978
45
Mesangial proliferative glomerulonephritis with irregular intramembranous deposits. Another variant of hypocoplementemic nephritis. (331950)
1977
46
Electron microscope studies of mesangial proliferative glomerulonephritis. (952081)
1976
47
Nephritogenic glycoprotein. VI. Induction of proliferative glomerulonephritis with the immunofluorescent 'mesangial pattern' in rats by a single injection of soluble glycoprotein isolated from human urine. (797522)
1975
48
Nephritogenic glycoprotein. IV. Induction of proliferative glomerulonephritis with immunofluorescent "mesangial pattern" in rats by a single injection of heterologous renal glycoprotein. (4604811)
1974
49
Mesangial proliferative glomerulonephritis in childhood. (4536432)
1973
50
The role of the mesangial cell in proliferative glomerulonephritis. (4573358)
1973

Genetic Variations for Mesangial Proliferative Glomerulonephritis

Expression for genes affiliated with Mesangial Proliferative Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for genes affiliated with Mesangial Proliferative Glomerulonephritis

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 50PharmGKB, 56SinoBiological
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Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2AGTR1
2
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9.8AGTR1, CCL2
3
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9.7PDGFD, MAPK1
4
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9.7AGTR1, CCR1, CCR5
59.6CCR1, CCL2, CCR5
6
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9.6TGFB1I1, CCR5
7
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9.5MAPK1, CCR1, CCR5
89.5VEGFA, MAPK1
9
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9.5CD79A, MAPK1, CCR5
10
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9.3IL6, MAPK1, EDN1
11
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9.3CCR5, CCR1, MAPK1, PTPRQ
12
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9.2CCL2, MAPK1, IL6
139.2CCL2, MAPK1, IL6
149.2VEGFA, MAPK1, FGF2
15
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9.2FGF2, MAPK1, VEGFA
16
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.2CCL2, VEGFA, IL6
17
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.2EDN1, VEGFA, MAPK1
18
Hide members
9.1CCR5, CCL2, CCR1, MAPK1
19
Transcription Androgen Receptor nuclear signaling
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9.0TGFB1I1, IL6, MAPK1
20
Hide members
9.0AGTR1, EDN1, CCR1, CCL2, CCR5
21
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9.0IL6, MAPK1, CCL2, CCR5
228.9CCL2, EDN1, MAPK1, IL6
23
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8.9CCR5, CCL2, CCR1, FGF2, IL6
248.8VEGFA, MAPK1, FGF2, IL6
258.7EDN1, VEGFA, MAPK1, IL6
26
Development PDGF signaling via STATs and NF-kB
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8.6IL6, FGF2, MAPK1, AGTR1, CCL2
27
Hide members
8.6CCR5, CCL2, CCR1, MAPK1, THY1
288.5PDGFD, VEGFA, MAPK1, FGF2, IL6
29
Hide members
7.8CCR5, CCL2, CCR1, MAPK1, FGF2, IL6
30
Hide members
7.4CCR5, CCL2, CCR1, PDGFD, EDN1, AGTR1

Compounds for genes affiliated with Mesangial Proliferative Glomerulonephritis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6CD79A
2suramin45 29 1112.4MAPK1
3pge24510.4VEGFA
4[125i]ccl3 (human)2910.2CCR1, CCR5
5[125i]ccl8 (human)2910.2CCR1, CCR5
6flu-ccl32910.2CCR5, CCR1
7bp-ccl32910.2CCR1, CCR5
8ccl142910.1CCR1, CCR5
9shikonin4510.0CCR5, CCR1, CCL2
10cyclosporin a45 29 6012.0EDN1, FGF2, CD79A
11mdms4510.0CCR1, CCL2, CCR5
12rosiglitazone45 50 29 11 2413.9IL6, MAPK1
13valsartan45 60 29 1112.9AGTR1, CCL2, EDN1
14mip 1alpha459.8IL6, CCL2, CCR5
15gw966245 2910.8CCL2, MAPK1, AGTR1
16hcec459.6CCL2, MAPK1, IL6
17heparin45 29 11 2412.6CD79A, VEGFA, CCR1, CCR5
18candesartan45 29 1111.6CCL2, AGTR1, VEGFA
19ccl345 2910.6IL6, CCR1, CCL2, CCR5
20tpck459.6MAPK1, IL6, CCL2
21ro 31 8220459.5VEGFA, CCL2, MAPK1
228-isoprostane459.5EDN1, AGTR1, IL6, CCL2
23verapamil45 50 29 11 2413.5AGTR1, CCL2, EDN1, FGF2
24bucillamine459.4FGF2, CD79A, VEGFA, IL6
25carvedilol45 50 29 1112.4VEGFA, AGTR1, EDN1
26groalpha459.3IL6, CCL2, CCR5
27apocynin45 6010.3VEGFA, EDN1, MAPK1
28vitamin d459.2IL6, CD79A, AGTR1, CCR5, CCL2
29ciglitazone45 2910.2CCL2, MAPK1, IL6
30cytochalasin d45 6010.2MAPK1, CCL2, CCR5, FGF2
31histamine45 29 2411.2EDN1, CCR5, CCL2, IL6, CD79A
32atorvastatin45 50 29 11 2413.2VEGFA, EDN1, CCL2, IL6
33gf 109203x45 6010.2FGF2, EDN1, VEGFA, MAPK1
34triptolide459.1VEGFA, CCL2, IL6, MAPK1
35isoproterenol45 1110.1EDN1, FGF2, AGTR1, MAPK1, CCL2
36tgf beta1459.1AGTR1, IL6, FGF2, CCL2
37prostacyclin459.1CCL2, FGF2, VEGFA, AGTR1, EDN1
38simvastatin45 50 60 29 11 2414.0IL6, AGTR1, VEGFA, CCL2, CCR5
39ang ii459.0MAPK1, VEGFA, AGTR1, EDN1, CCL2
40pd 98,059458.9IL6, FGF2, MAPK1, EDN1, CCL2
4115-deoxy-delta-12,14-prostaglandin j2458.8IL6, FGF2, MAPK1, CCL2, VEGFA
42dexamethasone45 50 29 1111.7CD79A, MAPK1, VEGFA, CCR1, FGF2, IL6
43hyaluronic acid45 249.7VEGFA, CD79A, FGF2, IL6
44ly294002458.7CCL2, VEGFA, MAPK1, FGF2, IL6
45n acetylcysteine458.6CCL2, AGTR1, VEGFA, MAPK1, CD79A, IL6
46sb 20358045 609.2CCL2, AGTR1, VEGFA, MAPK1, FGF2, EDN1
47genistein45 29 60 2 11 2413.2AGTR1, IL6, MAPK1, VEGFA, EDN1, FGF2
48vegf458.0IL6, FGF2, MAPK1, VEGFA, AGTR1, EDN1
49actinomycin d457.7CCR5, CCL2, CCR1, EDN1, AGTR1, VEGFA
50tyrosine457.2VEGFA, AGTR1, CCR1, CCR5, IL6, MAPK1

GO Terms for genes affiliated with Mesangial Proliferative Glomerulonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8THY1, IL6, CD79A, CCR1, CCR5

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:00240710.1CCR5, CCR1
2MAPK import into nucleusGO:00018910.0FGF2, MAPK1
3elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.0EDN1, AGTR1
4maternal process involved in parturitionGO:06013710.0EDN1, CCL2
5regulation of vascular endothelial growth factor productionGO:01057410.0CCL2, IL6
6negative regulation of hormone secretionGO:04688810.0IL6, EDN1
7chemokine-mediated signaling pathwayGO:07009810.0CCR5, CCL2, CCR1
8calcium-mediated signalingGO:0197229.9CCR5, EDN1, AGTR1
9regulation of vasoconstrictionGO:0192299.9AGTR1, EDN1
10cell migration involved in sprouting angiogenesisGO:0020429.7VEGFA, FGF2
11positive regulation of ERK1 and ERK2 cascadeGO:0703749.7CCR1, FGF2, IL6
12elevation of cytosolic calcium ion concentrationGO:0072049.7CCR5, CCR1, EDN1, AGTR1
13response to amino acid stimulusGO:0432009.7IL6, EDN1, CCL2
14MAPK cascadeGO:0001659.7CCR5, CCL2, MAPK1
15positive regulation of cell divisionGO:0517819.7FGF2, VEGFA, PDGFD
16cell surface receptor signaling pathwayGO:0071669.6CCR5, CCL2, CCR1, EDN1
17monocyte chemotaxisGO:0025489.6IL6, CCL2
18positive regulation of T cell activationGO:0508709.6THY1, CCL2
19organ morphogenesisGO:0098879.6FGF2, MAPK1, CCL2
20positive regulation of endothelial cell proliferationGO:0019389.6FGF2, VEGFA, CCL2
21G-protein coupled receptor signaling pathwayGO:0071869.5CCR5, CCL2, EDN1, AGTR1
22response to heatGO:0094089.4TGFB1I1, IL6, CCL2
23regulation of cell shapeGO:0083609.4IL6, VEGFA, CCL2
24positive regulation of blood vessel endothelial cell migrationGO:0435369.3FGF2, VEGFA
25positive regulation of cell migrationGO:0303359.2EDN1, VEGFA, MAPK1
26chemotaxisGO:0069359.2FGF2, MAPK1, CCR1, CCL2, CCR5
27positive regulation of cell proliferationGO:0082848.8EDN1, VEGFA, MAPK1, FGF2, IL6
28inflammatory responseGO:0069548.7CCR5, CCL2, CCR1, NFKBID, IL6

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:07179110.1CCR1, CCR5
2C-C chemokine bindingGO:01995710.0CCR1, CCR5
3C-C chemokine receptor activityGO:0164939.9CCR5, CCR1
4platelet-derived growth factor receptor bindingGO:0051619.4VEGFA, PDGFD
5heparin bindingGO:0082019.3FGF2, VEGFA, CCL2
6growth factor activityGO:0080839.0IL6, FGF2, VEGFA, PDGFD
7cytokine activityGO:0051258.9EDN1, VEGFA, FGF2, IL6

Products for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Sources for Mesangial Proliferative Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet