MCID: MSN001
MIFTS: 56

Mesangial Proliferative Glomerulonephritis malady

Rare diseases, Nephrological diseases categories
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Summaries for Mesangial Proliferative Glomerulonephritis

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Wikipedia:65 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

MalaCards based summary: Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to proliferative glomerulonephritis and glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds shikonin and mdms have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lung, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

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Mesangial Proliferative Glomerulonephritis, Aliases & Descriptions:

Name: Mesangial Proliferative Glomerulonephritis 8 42 62
Glomerulonephritis - Mesangial Proliferative 42
Glomerulonephritis Mesangial Proliferative 44
 
Mesangial Proliferative Gn 42
Increased Mesangial Matrix 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:4783
SNOMED-CT57 35546006
NCIt39 C35445

Related Diseases for Mesangial Proliferative Glomerulonephritis

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Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative glomerulonephritis32.6CCL2, CD79A
2glomerulonephritis32.2CCL2, CCR5, AGTR1, CD79A
3nephritis31.2CD79A, THY1, CCL2
4connective tissue disease30.6CD79A, IL6, CCL2
5chronic obstructive pulmonary disease30.5CCL2, CCR5, IL6
6proteinuria30.0EDN1, CD79A, THY1, VEGFA, CCL2, AGTR1
7arthritis29.9AGTR1, CCR1, IL6, CCR5, CCL2, FGF2
8myeloma29.5CCR1, VEGFA, IL6, MAPK1, CD79A, FGF2
9nephrotic syndrome10.7
10acute poststreptococcal glomerulonephritis10.6CD79A
11hepatitis10.5
12diabetic macular edema10.5VEGFA
13familial mediterranean fever10.4
14interstitial nephritis10.4
15castleman's disease10.4
16polymyositis10.4
17low renin hypertension10.4EDN1
18central retinal vein occlusion10.4VEGFA
19syphilis10.4CD79A, CCR5
20focal segmental glomerulosclerosis10.3CD79A, AGTR1
21lipoid nephrosis10.3CCL2, CD79A
22raynaud disease10.3AGTR1, EDN1
23cor pulmonale10.3AGTR1, EDN1
24arteriosclerosis10.3CCL2, EDN1
25multiple myeloma10.3
26myasthenia gravis10.3
27cryoglobulinemia10.3
28hepatitis c10.3
29hellp syndrome10.3
30hepatitis a10.3
31legionnaires' disease10.3
32mixed connective tissue disease10.3
33influenza10.3
34leprosy10.3
35psoriasis10.3
36urticaria10.3
37steroid-resistant nephrotic syndrome10.3
38c1q deficiency10.3
39hepatitis c virus10.3
40endotheliitis10.3
41sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.3
42familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.3
43idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation10.3
44periapical granuloma10.3CCL2, CCR5
45polyclonal hypergammaglobulinemia10.3CD79A, IL6
46portal hypertension10.3EDN1, AGTR1
47membranous glomerulonephritis10.2CD79A, CCR5, CCL2
48lupus nephritis10.2CCL2, CCR5, CD79A
49chronic myocardial ischemia10.2FGF2, VEGFA
50type 1 diabetes mellitus10.2CD79A, AGTR1, CCR5

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to mesangial proliferative glomerulonephritis

Symptoms for Mesangial Proliferative Glomerulonephritis

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Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

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Drug clinical trials:

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Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

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Anatomical Context for Mesangial Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

32
Brain, Kidney, Lung, Monocytes, T cells, Endothelial

Animal Models for Mesangial Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4EDN1, VEGFA, CCR1, IL6, CD79A, AGTR1
2MP:00053918.3FGF2, IL6, CCR5, CCL2, VEGFA
3MP:00053708.2VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
4MP:00053818.1EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
5MP:00020068.1VEGFA, CCL2, CCR5, IL6, MAPK1, FGF2
6MP:00053887.8THY1, VEGFA, CCR1, IL6, MAPK1
7MP:00053697.7EDN1, VEGFA, CCL2, CCR5, IL6, MAPK1
8MP:00053877.6VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
9MP:00053977.5VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
10MP:00053867.5VEGFA, PTPRQ, CCL2, CCR5, IL6, MAPK1
11MP:00053847.4VEGFA, CCL2, CCR5, CCR1, IL6, MAPK1
12MP:00053857.2EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
13MP:00107687.0EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
14MP:00053766.9EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
15MP:00036316.7FGF2, EDN1, THY1, VEGFA, PTPRQ, CCL2

Publications for Mesangial Proliferative Glomerulonephritis

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Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. (24701045)
2014
2
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. (24858931)
2014
3
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
4
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. (24649023)
2013
5
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. (22607047)
2012
6
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. (21349934)
2011
7
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
8
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. (17717029)
2007
9
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. (15917985)
2006
10
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
11
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
12
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. (15947989)
2005
13
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
14
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. (14600028)
2003
15
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
16
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. (12375274)
2002
17
Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. (12028445)
2002
18
PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. (11260393)
2001
19
Morphometric comparison of the quantity of the mesangial deposits in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (11518047)
2001
20
Localization in situ of type VI collagen protein and its mRNA in mesangial proliferative glomerulonephritis using renal biopsy sections. (9930877)
1999
21
Experimental mesangial proliferative glomerulonephritis (the anti-Thy-1.1 model). (10630692)
1999
22
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. (9809476)
1998
23
Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis. (9727007)
1998
24
Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. (9808091)
1998
25
Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis. (9773782)
1998
26
Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. (8651905)
1996
27
Mesangial proliferative glomerulonephritis and nephrotic syndrome with hepatitis A virus infection. (9141810)
1996
28
Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. (8755633)
1996
29
The novel regulatory mechanism of Fas system-mediated apoptosis in mesangial cells: implication to mesangial proliferative glomerulonephritis. (8619833)
1996
30
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
31
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
32
Mononuclear cell subsets in IgM mesangial proliferative glomerulonephritis. A comparative study with minimal change nephrotic syndrome and immunonegative mesangial proliferative glomerulonephritis. (8247183)
1993
33
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
34
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
35
IgM-associated primary diffuse mesangial proliferative glomerulonephritis: natural history and prognostic indicators. (1852859)
1991
36
Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition. (2044226)
1991
37
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
38
Involvement of IL-6 in mesangial proliferative glomerulonephritis. (2592764)
1989
39
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
40
Mesangial proliferative glomerulonephritis in a patient with hepatic hydatid cysts: a case report in an African male. (3232184)
1988
41
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
42
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
43
Mesangial proliferative glomerulonephritis with Legionnaires' disease. A case report. (3983750)
1985
44
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
45
Mesangial proliferative glomerulonephritis with IgM deposits. Clinicopathologic analysis and evidence for morphologic transitions. (6382035)
1984
46
Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. (6188567)
1983
47
Long term study of mesangial proliferative glomerulonephritis with IgM deposits. (7329978)
1981
48
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
49
Mesangial proliferative glomerulonephritis with irregular intramembranous deposits. Another variant of hypocoplementemic nephritis. (331950)
1977
50
Mesangial proliferative glomerulonephritis in childhood. (4536432)
1973

Variations for Mesangial Proliferative Glomerulonephritis

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Expression for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Expression patterns in normal tissues for genes affiliated with Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7AGTR1, MAPK1
2
Show member pathways
Peptide GPCRs37
9.7AGTR1, CCR1, CCR5
3
Show member pathways
9.6CCL2, CCR5, CCR1
49.6EDN1, MAPK1
59.5VEGFA, CCL2
69.5MAPK1, IL6
79.5MAPK1, IL6
89.4FGF2, VEGFA
9
Show member pathways
9.3EDN1, MAPK1, AGTR1
10
Show member pathways
9.2FGF2, PDGFD, MAPK1
11
Show member pathways
9.2MAPK1, IL6, CCR5
129.2EDN1, MAPK1, FGF2
13
Show member pathways
9.2CCL2, IL6, MAPK1
149.2MAPK1, IL6, CCL2
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1EDN1, IL6, MAPK1
16
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.1VEGFA, MAPK1, CD79A
17
Show member pathways
9.1MAPK1, CCR1, CCR5, CCL2
189.1VEGFA, CCL2, IL6
19
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0AGTR1, CD79A, MAPK1, EDN1
20
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.0VEGFA, CCL2, MAPK1
21
Show member pathways
9.0MAPK1, VEGFA, EDN1
22
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.0MAPK1, VEGFA, EDN1
23
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9CCR5, IL6, MAPK1, CD79A
24
Show member pathways
8.9EDN1, CCL2, CCR5, CCR1, AGTR1
25
Show member pathways
Angiogenesis37
8.9FGF2, MAPK1, VEGFA
26
Show member pathways
8.9FGF2, MAPK1, VEGFA
278.9VEGFA, MAPK1, FGF2
288.9VEGFA, MAPK1, FGF2
298.9VEGFA, MAPK1, FGF2
30
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9CCL2, CCR5, IL6, MAPK1
31
Show member pathways
8.8IL6, MAPK1, CD79A, FGF2
32
Show member pathways
8.8FGF2, CD79A, MAPK1, IL6
33
Show member pathways
8.8FGF2, CD79A, MAPK1, IL6
34
Show member pathways
8.8TGFB1I1, CCR5, MAPK1
358.8EDN1, CCL2, IL6, MAPK1
36
Show member pathways
8.7CCL2, CCR5, CCR1, IL6, FGF2
37
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
8.7MAPK1, IL6, TGFB1I1
38
Show member pathways
Signaling Pathways in Glioblastoma37
8.6FGF2, PDGFD, MAPK1, VEGFA
39
Show member pathways
8.6VEGFA, MAPK1, PDGFD, FGF2
40
Show member pathways
8.5THY1, CCL2, CCR5, CCR1, MAPK1
418.5EDN1, VEGFA, IL6, MAPK1
428.5VEGFA, IL6, MAPK1, FGF2
43
Show member pathways
8.5CCL2, IL6, MAPK1, AGTR1, FGF2
44
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5CCL2, IL6, MAPK1, AGTR1, FGF2
45
Show member pathways
8.5FGF2, AGTR1, MAPK1, IL6, CCL2
468.1VEGFA, IL6, MAPK1, PDGFD, FGF2
47
Show member pathways
7.9FGF2, MAPK1, IL6, CCR1, CCR5, CCL2
48
Show member pathways
7.6EDN1, VEGFA, CCL2, CCR5, CCR1, IL6
49
Show member pathways
7.4TGFB1I1, CCL2, CCR5, CCR1, IL6, MAPK1
50
Show member pathways
7.1EDN1, VEGFA, CCL2, CCR5, CCR1, MAPK1

Compounds for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Compounds related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1shikonin4410.0CCR1, CCR5, CCL2
2mdms449.9CCR1, CCR5, CCL2
3valsartan44 61 28 1112.8CCL2, EDN1, AGTR1
4mip 1alpha449.8CCL2, IL6, CCR5
5irbesartan44 28 50 1112.7CCL2, EDN1, AGTR1
6gw966244 2810.7MAPK1, AGTR1, CCL2
7ccl344 2810.5CCL2, CCR5, CCR1, IL6
8hcec449.5MAPK1, IL6, CCL2
98-isoprostane449.4EDN1, CCL2, IL6, AGTR1
10tpck449.4MAPK1, IL6, CCL2
11verapamil44 28 50 24 1113.3FGF2, EDN1, AGTR1, CCL2
12ro 31 8220449.3CCL2, VEGFA, MAPK1
13candesartan44 50 28 1112.2CCL2, AGTR1, VEGFA
14vitamin d449.2CCR5, IL6, CD79A, AGTR1, CCL2
15carvedilol44 50 28 1112.2AGTR1, EDN1, VEGFA
16bucillamine449.2VEGFA, CD79A, FGF2, IL6
17norepinephrine44 24 1111.1CCL2, CD79A, AGTR1, IL6, EDN1
18rosiglitazone28 44 50 24 1113.1AGTR1, MAPK1, IL6, CCL2
19histamine44 28 2411.1CCR5, CD79A, EDN1, IL6, CCL2
20tgf beta1449.1IL6, AGTR1, CCL2, FGF2
21cytochalasin d44 6110.1FGF2, MAPK1, CCR5, CCL2
22atorvastatin44 50 28 24 1113.0CCL2, IL6, VEGFA, EDN1
23triptolide448.9MAPK1, IL6, CCL2, VEGFA
24isoproterenol44 119.9FGF2, AGTR1, MAPK1, CCL2, EDN1
25simvastatin44 50 61 28 24 1113.9AGTR1, IL6, VEGFA, CCL2, CCR5
26apocynin44 619.9VEGFA, EDN1, MAPK1
27gf 109203x44 619.8EDN1, VEGFA, FGF2, MAPK1
28prostacyclin448.8CCL2, AGTR1, FGF2, EDN1, VEGFA
29suramin44 28 1110.8FGF2, AGTR1, CD79A, MAPK1, VEGFA
30cyclosporin a44 28 6110.8FGF2, EDN1, CCR5, IL6, CD79A, AGTR1
31herbimycin a44 619.8MAPK1, FGF2, CCL2, EDN1, IL6
32ang ii448.8VEGFA, EDN1, AGTR1, CCL2, MAPK1
33heparin44 28 24 1111.8VEGFA, FGF2, AGTR1, CCR1, CD79A, CCR5
34pd 98,059448.7CCL2, FGF2, MAPK1, IL6, EDN1
35alanine448.6CCR5, CCR1, IL6, AGTR1, FGF2, CD79A
3615-deoxy-delta-12,14-prostaglandin j2448.6MAPK1, VEGFA, FGF2, CCL2, IL6
37phosphatidylinositol448.5CCR1, EDN1, MAPK1, CCL2, FGF2, AGTR1
38hyaluronic acid44 249.4VEGFA, IL6, CD79A, FGF2
39ly294002448.4MAPK1, CCL2, IL6, VEGFA, FGF2
40n acetylcysteine448.4IL6, AGTR1, CD79A, MAPK1, VEGFA, CCL2
41nitric oxide44 24 1110.4CCL2, EDN1, AGTR1, MAPK1, IL6, CCR1
42estrogen448.0VEGFA, CCR5, FGF2, CD79A, IL6, MAPK1
43sb 20358044 618.9IL6, VEGFA, CCL2, MAPK1, AGTR1, FGF2
44genistein44 28 61 2 24 1112.9CCL2, MAPK1, AGTR1, IL6, VEGFA, FGF2
45cycloheximide447.7AGTR1, FGF2, EDN1, VEGFA, CCL2, CCR1
46vegf447.6IL6, MAPK1, FGF2, AGTR1, CD79A, CCL2
47dexamethasone44 50 28 1110.5CCL2, CCR5, CCR1, IL6, FGF2, MAPK1
48pge2447.4CD79A, FGF2, MAPK1, IL6, CCR1, CCR5
49actinomycin d447.4CCL2, EDN1, VEGFA, CCR5, CCR1, IL6
50tyrosine446.7TGFB1I1, VEGFA, THY1, CCR5, CCR1, IL6

GO Terms for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CD79A, IL6, CCR1, CCR5, THY1
2extracellular spaceGO:0056158.3FGF2, IL6, CCL2, VEGFA, EDN1
3extracellular regionGO:0055767.6EDN1, VEGFA, CCL2, IL6, PDGFD, FGF2

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotaxisGO:09002610.3CCR1, CCR5
2dendritic cell chemotaxisGO:00240710.3CCR1, CCR5
3positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.2AGTR1, EDN1
4maternal process involved in parturitionGO:06013710.1EDN1, CCL2
5regulation of vasoconstrictionGO:01922910.1EDN1, AGTR1
6regulation of vascular endothelial growth factor productionGO:01057410.1IL6, CCL2
7chemokine-mediated signaling pathwayGO:07009810.0CCL2, CCR5, CCR1
8negative regulation of hormone secretionGO:04688810.0EDN1, IL6
9monocyte chemotaxisGO:00254810.0CCL2, IL6
10MAPK import into nucleusGO:00018910.0MAPK1, FGF2
11positive regulation of T cell activationGO:0508709.9THY1, CCL2
12calcium-mediated signalingGO:0197229.9AGTR1, CCR5, EDN1
13regulation of angiogenesisGO:0457659.9FGF2, IL6
14B cell receptor signaling pathwayGO:0508539.8CD79A, MAPK1
15lipopolysaccharide-mediated signaling pathwayGO:0316639.8MAPK1, CCL2
16cell migration involved in sprouting angiogenesisGO:0020429.8VEGFA, FGF2
17vascular endothelial growth factor receptor signaling pathwayGO:0480109.8CCL2, VEGFA
18positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, FGF2
19positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGF2, IL6, CCR1
20response to amino acidGO:0432009.7IL6, CCL2, EDN1
21positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, EDN1
22positive regulation of cytosolic calcium ion concentrationGO:0072049.7EDN1, CCR5, CCR1, AGTR1
23MAPK cascadeGO:0001659.7MAPK1, CCR5, CCL2
24response to antibioticGO:0466779.7IL6, CCL2
25positive chemotaxisGO:0509189.7VEGFA, FGF2
26cell surface receptor signaling pathwayGO:0071669.6CCR1, CCR5, CCL2, EDN1
27organ morphogenesisGO:0098879.6FGF2, MAPK1, CCL2
28cell-cell signalingGO:0072679.6CCR1, CCR5, EDN1
29G-protein coupled receptor signaling pathwayGO:0071869.6AGTR1, CCR5, CCL2, EDN1
30positive regulation of cell divisionGO:0517819.5FGF2, PDGFD, VEGFA
31inflammatory responseGO:0069549.5CCL2, CCR5, CCR1, IL6
32positive regulation of endothelial cell proliferationGO:0019389.5VEGFA, CCL2, FGF2
33cellular response to interleukin-1GO:0713479.5CCL2, EDN1
34regulation of cell shapeGO:0083609.4IL6, CCL2, VEGFA
35response to hypoxiaGO:0016669.4EDN1, VEGFA, CCL2
36cytokine-mediated signaling pathwayGO:0192219.3CCL2, CCR1, IL6
37positive regulation of cell migrationGO:0303359.3EDN1, VEGFA, MAPK1
38response to heatGO:0094089.3TGFB1I1, CCL2, IL6
39angiogenesisGO:0015259.2CCL2, VEGFA, THY1
40chemotaxisGO:0069359.1FGF2, MAPK1, CCR1, CCR5, CCL2
41platelet activationGO:0301689.0VEGFA, IL6, MAPK1
42positive regulation of transcription, DNA-templatedGO:0458938.5FGF2, MAPK1, IL6, TGFB1I1
43positive regulation of cell proliferationGO:0082848.5EDN1, VEGFA, IL6, MAPK1, FGF2

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:07179110.2CCR1, CCR5
2C-C chemokine bindingGO:01995710.1CCR1, CCR5
3C-C chemokine receptor activityGO:01649310.0CCR5, CCR1
4phosphatidylinositol phospholipase C activityGO:0044359.9CCR1, CCR5
5chemokine receptor activityGO:0049509.8CCR1, CCR5
6platelet-derived growth factor receptor bindingGO:0051619.6PDGFD, VEGFA
7chemoattractant activityGO:0420569.1FGF2, VEGFA
8heparin bindingGO:0082019.1VEGFA, CCL2, FGF2
9growth factor activityGO:0080838.9FGF2, PDGFD, IL6, VEGFA
10cytokine activityGO:0051258.8EDN1, VEGFA, IL6, FGF2
11protein bindingGO:0055156.1EDN1, THY1, VEGFA, TGFB1I1, CCR5, CCR1

Products for genes affiliated with Mesangial Proliferative Glomerulonephritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Mesangial Proliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet