MCID: MSN001
MIFTS: 41

Mesangial Proliferative Glomerulonephritis malady

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

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Aliases & Descriptions for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 10 45 12 65
Glomerulonephritis - Mesangial Proliferative 45
 
Glomerulonephritis Mesangial Proliferative 47
Mesangial Proliferative Gn 45

Classifications:



External Ids:

Disease Ontology10 DOID:4783
SNOMED-CT59 35546006
NCIt42 C35445
UMLS65 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

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Wikipedia:68 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

MalaCards based summary: Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to crohn's disease and gestational diabetes. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and TNF signaling pathway. Affiliated tissues include prostate, breast and heart, and related mouse phenotypes are renal/urinary system and cellular.

Related Diseases for Mesangial Proliferative Glomerulonephritis

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Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease30.7EDN1, IL6
2gestational diabetes30.6CCL2, EDN1
3plasmacytoma30.5CD79A, IL6
4thyroid cancer30.3CCL2, EDN1, IL6
5systemic lupus erythematosus29.6CCL2, CD79A, GAS6, IL6
6c1q deficiency10.8
7sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.8
8familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.8
9idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation10.8
10mammary paget's disease10.4FGF2, IL6
11congenital dyserythropoietic anemia10.4CCL2, IL6
12residual stage angle-closure glaucoma10.4FGF2, IL6
13intermediate dend syndrome10.4EDN1, IL6
14eccrine sweat gland neoplasm10.4CCL2, IL6
15childhood kidney cell carcinoma10.4CCL2, IL6
16dyskinesia of esophagus10.3CCL2, IL6
17non-langerhans-cell histiocytosis10.3CCL2, CCR5
18melanoma10.3
19secretory diarrhea10.3CCL2, IL6
20amusia10.3CCR5, IL6
21brain ischemia10.3EDN1, IL6
22placental abruption10.3CCR5, IL6
23hypopharynx cancer10.2CCR5, IL6
24tracheal stenosis10.2EDN1, IL6
25plasma protein metabolism disease10.2CD79A, IL6
26hepatitis10.2
27leukemia10.2
28lymphoma10.2
29sensorineural hearing loss10.2
30goiter10.2
31ovarian cancer10.2
32interstitial lung disease10.2
33pancreatitis10.2
34pneumonia10.2
35thyroiditis10.2
36neuronitis10.2
37lung disease10.2
38lupus erythematosus10.2
39glomus tympanicum tumor10.2CCL2, CD79A
40protein-energy malnutrition10.2FGF2, IL6
41collagenous colitis10.2CD79A, IL6
42intestinal impaction10.2CD79A, IL6
43granulomatous amebic encephalitis10.2CD79A, IL6
44refractory plasma cell neoplasm10.2CD79A, IL6
45optic neuritis10.2CD79A, IL6
46cerebellopontine angle primitive neuroectodermal10.2CCR1, CCR5
47crescentic glomerulonephritis10.2CCL2, CD79A
48pyrimidine metabolic disorder10.2CCL2, IL6
49subacute glomerulonephritis10.2CD79A, FGF2
50narcissistic personality disorder10.2CD79A, IL6

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to mesangial proliferative glomerulonephritis

Symptoms for Mesangial Proliferative Glomerulonephritis

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Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

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Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Calcitriolapproved, nutraceuticalPhase 416132222-06-3134070, 5280453
Synonyms:
(1R,3S)-5-{2-[(1R,3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
(1S,3R,5Z,7e)-9,10-Secocholesta-5,7,10-triene-1,3,25-triol
(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(1alpha,3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol
(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol
(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol
(5Z,7e)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
1 alpha,25-Dihydroxyvitamin D3
1,25 (OH)2 D3
1,25 Dihydroxycholecalciferol
1,25(OH)2-20epi-D3
1,25(OH)2D3 & CD4
1,25(OH2)D3
1,25-(OH)2-D3
1,25-(OH)2D3
1,25-DHCC
1,25-DIHYDROXYCHOLECALCIFEROL
1,25-Dihydroxycholecalciferol
1,25-Dihydroxycholecaliferol
1,25-Dihydroxyvitamin D
1,25-Dihydroxyvitamin D3
1,25-dihydroxy vitamin D3
1,25-dihydroxy-20-epi-Vitamin D3
1,25-dihydroxycholecalciferol
1,25D3
1-alpha,-1,25-Dihydroxyvitamin D3
1-alpha,25-Dihydroxycholecalciferol
1-alpha,25-Dihydroxyvitamin D3
1-alpha-25-Dihydroxyvitamin D3
1-alpha-25-dihydroxyvitamin D3
1.Alpha.,25-Dihydroxy-26,27-hexadeuterovitamin D3
17936_FLUKA
17936_SIGMA
1a,25-(OH)2D3
1a,25-Dihydroxycholecalciferol
1a,25-Dihydroxyvitamin D3
1alpha,25(OH)2-D3
1alpha,25(OH)2D3
1alpha,25-Dihydroxycholecalciferol
1alpha,25-Dihydroxyvitamin D
1alpha,25-Dihydroxyvitamin D3
1db1
1α,25(OH)2D3
1α,25-dihydroxycholecalciferol
1α,25-dihydroxyvitamin D3
20-epi-1alpha,25-dihydroxycholecaliferol
25-Dihydroxycholecalciferol
32222-06-3
5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1.alpha.,3.beta,.5Z,7E)- & CD4
9,10-seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha, 3beta, 25-triol
AC-1859
AC1NQX1S
 
Ambap32222-06-3
Asentar
BCBcMAP01_000160
BML2-E03
BSPBio_001287
C01673
CCRIS 5522
CD-2027
CHEBI:17823
CHEMBL846
CID5280453
CPD000466393
Calcijex
Calcijex, Silkis, Rocaltrol, Topitriol, Cholecalciferol,Calcitriol
Calcitriol
Calcitriol (JAN/USAN/INN)
Calcitriol [USAN:INN:BAN:JAN]
Calcitriolum
Calcitriolum [INN-Latin]
D00129
D1530_SIGMA
DN 101
DN-101
Decostriol
Dihydroxyvitamin D3
EINECS 250-963-8
HMS1361A09
HMS1791A09
HMS1989A09
HMS2051F06
HMS2089N03
HSDB 3482
IDI1_033757
LMST03020258
LS-53093
MC-1288
MC1288
MLS000759536
MLS001424122
MolPort-002-045-698
NCGC00161327-01
NCGC00161327-04
Ro 21-5535
Ro 215535
Ro-21-5535
Rocaltrol
Rocaltrol (TN)
S1466_Selleck
SAM001246772
SMR000466393
Silkis
Soltriol
Spectrum5_002061
Topitriol
Toptriol
U 49562
Vectical
ZINC03924790
calcitriol
vit D
2MicronutrientsPhase 4, Phase 33901
3Trace ElementsPhase 4, Phase 33900
4Vasoconstrictor AgentsPhase 41303
5Immunologic FactorsPhase 4, Phase 318483
6VitaminsPhase 4, Phase 33857
7ImmunoglobulinsPhase 4, Phase 34477
8Bone Density Conservation AgentsPhase 4, Phase 32600
9Calcium, DietaryPhase 44678
10Immunoglobulin APhase 4, Phase 3110
11AntibodiesPhase 4, Phase 34477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Calcitriol in the Treatment of Immunoglobulin A (IgA) NephropathyCompletedNCT00319761Phase 4
2Calcitriol in the Treatment of Immunoglobulin A NephropathyRecruitingNCT00862693Phase 4
3Paricalcitol for the Treatment of Immunoglobulin A NephropathyWithdrawnNCT00599963Phase 3

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

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Anatomical Context for Mesangial Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

33
Prostate, Breast, Heart, Lung, Skin, Colon, Testes

Animal Models for Mesangial Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6CCR1, CD79A, EDN1, GAS6, IL6
2MP:00053847.6AXL, CCR1, CCR5, CD79A, FGF2, GAS6
3MP:00053977.4AXL, CCR1, CCR5, CD79A, FGF2, GAS6
4MP:00053857.2AXL, CCR1, CCR5, EDN1, FGF2, GAS6
5MP:00053877.1AXL, CCL2, CCR1, CCR5, CD79A, GAS6
6MP:00053767.0AXL, CCR1, CCR5, CD79A, EDN1, FGF2

Publications for Mesangial Proliferative Glomerulonephritis

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Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Coccidioidomycosis and the skin: a comprehensive review. (26560205)
2015
2
Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. (25889144)
2015
3
Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells. (23708664)
2014
4
One-Stage Surgical Correction of Congenital Tracheal Stenosis Complicated with Congenital Heart Disease in Infants and Young Children. (25109422)
2014
5
Maintenance of multipotency in human dermal fibroblasts treated with Xenopus laevis egg extract requires exogenous fibroblast growth factor-2. (24405062)
2014
6
The Effects of Mechanical Stimulation of the Feet on Gait and Cardiovascular Autonomic Control in Parkinson's Disease. (24436294)
2014
7
Drug discovery for autism spectrum disorder: challenges and opportunities. (24080699)
2013
8
OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. (23651028)
2013
9
Infantile hypertrophic pyloric stenosis (IHPS): it can take away your breath, alertness, wee and poo. (24259528)
2013
10
Lack of association between Bax promoter (-248G>A) single nucleotide polymorphism and susceptibility towards cancer: evidence from a meta-analysis. (24147019)
2013
11
Oxidative and antioxidative status of children with acute bronchiolitis. (23796358)
2013
12
Cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. (22637205)
2012
13
Juvenile xanthogranuloma presenting as bilateral non-infiltrative extraconal superior orbital tumour in a 27 year old nigerian woman: features, management and outcome. (23071425)
2012
14
Ischemic heart disease and stroke before and during endocrine treatment for prostate cancer in PCBaSe Sweden. (21387298)
2012
15
Acamprosate and Baclofen were Not Effective in the Treatment of Pathological Gambling: Preliminary Blind Rater Comparison Study. (21713109)
2011
16
Focal dystonia in musicians: phenomenology, pathophysiology, triggering factors, and treatment. (20795373)
2010
17
Survival and relapse in patients with thrombotic thrombocytopenic purpura. (20032506)
2010
18
Question: Can you identify this condition? Palmoplantar eccrine hidradenitis. (20631279)
2010
19
Mitotically active deep juvenile xanthogranuloma. (20123455)
2010
20
Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. (19210964)
2009
21
A novel connexin 50 (GJA8) mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract. (18334966)
2008
22
Induction therapy for poor-prognosis anal canal carcinoma: a phase II study of the cancer and Leukemia Group B (CALGB 9281). (18490648)
2008
23
Dermoscopy of trichostasis spinulosa. (18711103)
2008
24
Repression of p53-mediated transcription by adenovirus E1B 55-kDa does not require corepressor mSin3A and histone deacetylases. (17209038)
2007
25
Understanding ribonucleotide reductase inactivation by gemcitabine. (17636467)
2007
26
Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. (17095757)
2007
27
Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae. (17720143)
2007
28
Genetic changes in advanced gastrointestinal stromal tumor (GIST) patients during imatinib mesylate treatment. (17024483)
2006
29
Association analysis of apolipoprotein E genotype and risk of depressive symptoms in Alzheimer's disease. (15627763)
2005
30
INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (15525639)
2005
31
Further delineation of Al-Gazali syndrome (multiple skeletal abnormalities with anterior segment anomalies of the eye and early lethality) in a Malaysian family. (15602085)
2005
32
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients. (15121785)
2004
33
The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient. (12926841)
2003
34
Mutational analysis of MECP2 gene in Rett syndrome]. (12170461)
2002
35
The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders. (12020611)
2002
36
Novel germline RET mutation segregating with papillary thyroid carcinomas. (11746981)
2001
37
Eosinophilic cystitis presenting as urinary retention. (11150946)
2001
38
Development of resistance and cross-resistance in Pseudomonas aeruginosa exposed to subinhibitory antibiotic concentrations. (10379686)
1999
39
Removal and inactivation of hepatitis B virus from contaminated pooled plasma in a large-scale manufacturing process for factor VIII and human serum albumin. (10341335)
1999
40
Male breast cancer: Austrian experience. (7571664)
1995
41
Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors. (7794080)
1995
42
Plasma concentrations of prolactin, noradrenaline, vasopressin and oxytocin during and after a prolonged epileptic seizure. (7801741)
1994
43
IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. (8245471)
1993
44
Postnatal development of circulating cholecystokinin and secretin, pancreatic growth, and exocrine function in guinea pigs. (7681093)
1993
45
Role of peripherally infused angiotensin II on the human hypothalamic-pituitary-adrenal axis. (1645236)
1991
46
The role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (2412354)
1985
47
Acute non-tuberculous empyema in children. A 25-year review. (6715963)
1984
48
The primary structure of the human epsilon-globin gene. (6254663)
1980
49
50

Variations for Mesangial Proliferative Glomerulonephritis

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Expression for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.5CD79A, FGF2, IL6
29.4CCL2, EDN1, IL6
39.4CCL2, EDN1, IL6
49.3CCR1, CD79A, IL6
5
Show member pathways
9.2CCL2, CCR1, CCR5
6
Show member pathways
8.5FGF2, GAS6, IL6, PDGFD
7
Show member pathways
8.1CD79A, FGF2, GAS6, IL6, PDGFD
8
Show member pathways
7.8AXL, FGF2, GAS6, IL6, PDGFD
9
Show member pathways
7.5AXL, CD79A, FGF2, GAS6, IL6, PDGFD
10
Show member pathways
7.5AXL, CCL2, FGF2, GAS6, IL6, PDGFD
11
Show member pathways
7.5AXL, CCL2, FGF2, GAS6, IL6, PDGFD
12
Show member pathways
7.1CCL2, CCR1, CCR5, FGF2, GAS6, IL6
13
Show member pathways
6.5AXL, CCL2, CCR1, CCR5, FGF2, GAS6
14
Show member pathways
6.5AXL, CCL2, CCR1, CCR5, FGF2, GAS6

GO Terms for genes affiliated with Mesangial Proliferative Glomerulonephritis

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Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:004667710.5CCL2, IL6
2positive regulation of nitric oxide biosynthetic processGO:004542910.4EDN1, IL6
3positive regulation of endothelial cell migrationGO:001059510.3EDN1, FGF2
4maternal process involved in parturitionGO:006013710.3CCL2, EDN1
5negative regulation of hormone secretionGO:004688810.3EDN1, IL6
6regulation of angiogenesisGO:004576510.3FGF2, IL6
7response to amino acidGO:004320010.3EDN1, IL6
8cellular response to drugGO:003569010.2CCL2, EDN1
9cell growthGO:001604910.2EDN1, IL6
10viral genome replicationGO:001907910.2CCL2, GAS6
11response to bacteriumGO:000961710.2CCL2, IL6
12organ regenerationGO:003110010.1CCL2, GAS6
13positive regulation of monocyte chemotaxisGO:009002610.1CCL2, CCR1
14cellular response to interferon-gammaGO:007134610.0CCL2, EDN1
15cellular response to dexamethasone stimulusGO:007154910.0CCL2, IL6
16apoptotic cell clearanceGO:004327710.0AXL, GAS6
17negative regulation of dendritic cell apoptotic processGO:200066910.0AXL, GAS6
18chemokine-mediated signaling pathwayGO:00700989.9CCL2, CCR5
19negative regulation of interferon-gamma productionGO:00326899.9AXL, GAS6
20positive regulation of natural killer cell differentiationGO:00328259.9AXL, GAS6
21viral entry into host cellGO:00467189.8CCR5, GAS6
22dendritic cell differentiationGO:00970289.8AXL, GAS6
23cytokine-mediated signaling pathwayGO:00192219.8CCL2, CCR1, IL6
24cellular response to interleukin-1GO:00713479.8CCL2, EDN1, IL6
25positive regulation of cell divisionGO:00517819.8FGF2, PDGFD
26response to woundingGO:00096119.8CCL2, CCR1, IL6
27cellular response to transforming growth factor beta stimulusGO:00715609.8EDN1, PDGFD
28positive regulation of protein kinase B signalingGO:00518979.7FGF2, GAS6, IL6
29enzyme linked receptor protein signaling pathwayGO:00071679.7AXL, GAS6
30phagocytosisGO:00069099.7AXL, GAS6
31MAPK cascadeGO:00001659.6CCL2, CCR5, FGF2
32response to heatGO:00094089.5CCL2, IL6
33positive regulation of MAP kinase activityGO:00434069.4EDN1, FGF2, PDGFD
34immune responseGO:00069559.4CCL2, CCR1, IL6
35chemotaxisGO:00069359.3CCL2, CCR1, FGF2
36cell-cell signalingGO:00072679.3CCR1, CCR5, EDN1
37positive regulation of gene expressionGO:00106289.3FGF2, GAS6, IL6
38cellular response to lipopolysaccharideGO:00712229.2AXL, CCL2, IL6
39positive regulation of smooth muscle cell proliferationGO:00486619.0EDN1, FGF2, IL6, PDGFD
40positive regulation of ERK1 and ERK2 cascadeGO:00703748.8CCL2, CCR1, FGF2, GAS6, IL6

Sources for Mesangial Proliferative Glomerulonephritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet