MCID: MSN004
MIFTS: 35

Mesenchymal Cell Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Cell Neoplasm

MalaCards integrated aliases for Mesenchymal Cell Neoplasm:

Name: Mesenchymal Cell Neoplasm 12 14 69
Benign Miscellaneous Mesenchymal Tumor 12
Mesenchymal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3350
NCIt 46 C6587 C7059

Summaries for Mesenchymal Cell Neoplasm

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

MalaCards based summary : Mesenchymal Cell Neoplasm, also known as benign miscellaneous mesenchymal tumor, is related to carney triad and malignant mesenchymoma. An important gene associated with Mesenchymal Cell Neoplasm is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include bone and liver, and related phenotype is neoplasm.

Related Diseases for Mesenchymal Cell Neoplasm

Diseases related to Mesenchymal Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 carney triad 32.0 KIT PDGFRA
2 malignant mesenchymoma 31.7 EWSR1 KIT MYOD1
3 gastrointestinal stromal tumor 31.5 CD34 KIT PDGFRA
4 gallbladder sarcoma 30.9 CD34 KIT MYOD1
5 inflammatory myofibroblastic tumor 30.7 ALK CLTC KIT RANBP2 TPM3 TPM4
6 congenital mesoblastic nephroma 30.0 KIT SMARCB1
7 rhabdomyosarcoma 29.4 ALK EWSR1 MYOD1
8 histiocytoma 28.8 ALK EWSR1 KIT MYOD1
9 mediastinal mesenchymal tumor 12.0
10 oncogenic osteomalacia 11.3
11 vaginal carcinosarcoma 11.1
12 ovarian carcinosarcoma 11.1
13 central nervous system mesenchymal non-meningothelial tumor 10.9
14 fetal lung interstitial tumor 10.9
15 paraganglioma and gastric stromal sarcoma 10.9
16 myoma 10.9
17 reticular perineurioma 10.5 KIT PDGFRA
18 sm-ahnmd 10.5 KIT PDGFRA
19 gastric leiomyosarcoma 10.5 KIT PDGFRA
20 desmoid tumor 10.4 KIT PDGFRA
21 hypereosinophilic syndrome, idiopathic 10.4 KIT PDGFRA
22 sarcomatoid renal cell carcinoma 10.4 KIT PDGFRA
23 pediatric fibrosarcoma 10.4 CLTC TPM3
24 endometrial small cell carcinoma 10.4 KIT PDGFRA
25 pulmonary vein stenosis 10.4 KIT PDGFRA
26 esophagus sarcoma 10.3 CREB3L2 KIT
27 lung adenoid cystic carcinoma 10.3 ALK KIT PDGFRA
28 neurilemmoma 10.3 KIT PDGFRA SMARCB1
29 pleomorphic carcinoma 10.3 ALK KIT
30 undifferentiated pleomorphic sarcoma 10.3 KIT PDGFRA
31 osteomalacia 10.3
32 kidney rhabdoid cancer 10.3 EWSR1 SMARCB1
33 chronic eosinophilic leukemia 10.3 KIT PDGFRA TPM3
34 senile angioma 10.3 HBA1 KIT
35 extraosseous chondrosarcoma 10.3 EWSR1 SMARCB1
36 prostate embryonal rhabdomyosarcoma 10.3 KIT MYOD1
37 prostate rhabdomyosarcoma 10.2 KIT MYOD1
38 neurofibromatosis, type i 10.2 KIT PDGFRA
39 heart sarcoma 10.1 CREB3L2 KIT PDGFRA
40 gallbladder leiomyoma 10.1 CD34 KIT
41 fibrosarcoma of bone 10.1 CREB3L2 KIT PDGFRA
42 lung leiomyosarcoma 10.1 CD34 KIT
43 liver leiomyoma 10.1 CD34 KIT
44 deep leiomyoma 10.1 CD34 KIT
45 ewing's family of tumors 10.1 EWSR1 KIT
46 extracutaneous mastocytoma 10.1 CD34 KIT
47 small intestine leiomyosarcoma 10.1 CD34 KIT
48 small intestinal sarcoma 10.1 CD34 KIT
49 prostate leiomyosarcoma 10.1 CD34 KIT
50 diffuse cutaneous mastocytosis 10.1 CD34 KIT

Graphical network of the top 20 diseases related to Mesenchymal Cell Neoplasm:



Diseases related to Mesenchymal Cell Neoplasm

Symptoms & Phenotypes for Mesenchymal Cell Neoplasm

MGI Mouse Phenotypes related to Mesenchymal Cell Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ALK CD34 KIT MYOD1 PDGFRA SMARCB1

Drugs & Therapeutics for Mesenchymal Cell Neoplasm

Drugs for Mesenchymal Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Adjuvants, Anesthesia Phase 3
4 Analgesics Phase 3
5 Analgesics, Opioid Phase 3
6 Anesthetics Phase 3,Phase 2
7 Anesthetics, General Phase 3
8 Anesthetics, Intravenous Phase 3
9 Central Nervous System Depressants Phase 3
10 Liver Extracts Phase 3
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Cola Nutraceutical Phase 3
14
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
15
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
16
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
17
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
18
Epirubicin Approved Phase 2 56420-45-2 41867
19
Etoposide Approved Phase 2 33419-42-0 36462
20
Ifosfamide Approved Phase 2 3778-73-2 3690
21
Lenograstim Approved, Investigational Phase 2 135968-09-1
22
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
23
ponatinib Approved, Investigational Phase 2 943319-70-8 24826799
24
Nintedanib Approved Phase 2 656247-17-5 56843413
25
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
26
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
27
Doxil Approved June 1999 Phase 2 31703
28 Anti-Bacterial Agents Phase 2
29 Antibiotics, Antitubercular Phase 2
30 Topoisomerase Inhibitors Phase 2
31 Alkylating Agents Phase 2
32 Anti-Infective Agents Phase 2,Phase 1
33 Antimitotic Agents Phase 2
34 Antineoplastic Agents, Phytogenic Phase 2
35 Antirheumatic Agents Phase 2
36 Etoposide phosphate Phase 2
37 Immunosuppressive Agents Phase 2,Phase 1
38 Isophosphamide mustard Phase 2 0
39 Nucleic Acid Synthesis Inhibitors Phase 2
40 Imatinib Mesylate Phase 2 123596
41 Protein Kinase Inhibitors Phase 2
42 PONATINIB  Phase 2
43 Antibodies Phase 1, Phase 2
44 Antibodies, Blocking Phase 1, Phase 2
45 Antimetabolites Phase 1, Phase 2
46 Antimetabolites, Antineoplastic Phase 1, Phase 2
47 Antiviral Agents Phase 1, Phase 2
48 Immunoglobulins Phase 1, Phase 2
49 Mitogens Phase 2
50 tyrosine Nutraceutical Phase 2

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Multicenter Trial With PegLiposomal Doxorubicin and Carboplatin Combination Chemotherapy in Gynecological Sarcomas and Mixed Epithelial-Mesenchymal Tumors Completed NCT00815945 Phase 2 PegLiposomal Doxorubicin;Carboplatin
3 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum Completed NCT00592345 Phase 1, Phase 2
5 Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST) Completed NCT01172548 Phase 2 imatinib mesylate
6 A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed NCT01874665 Phase 2 ponatinib
7 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
8 Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma Recruiting NCT03123276 Phase 1, Phase 2 Pembrolizumab;Gemcitabine
9 Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting NCT03109301 Phase 2 Selumetinib (AZD6244 hyd sulfate)
10 Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Active, not recruiting NCT02015065 Phase 2 Vandetanib
11 Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore) Withdrawn NCT02766842 Phase 2
12 Study of Donor Derived, Multi-virus-specific, Cytotoxic T-Lymphocytes for Relapsed/Refractory Neuroblastoma Completed NCT01460901 Phase 1
13 NHS-IL12 for Solid Tumors Recruiting NCT01417546 Phase 1 NHS-IL-12
14 68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia Unknown status NCT01524016 Early Phase 1 68Ga-DOTATATE
15 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
16 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Completed NCT02884154
17 the Laparoscopic and Endoscopic Cooperative Surgery of Gastrointestinal Stromal Tumor Recruiting NCT02763748
18 The Clinical Relevance of Immune Cells and CTC in HNSCC Patients Recruiting NCT02420600
19 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Recruiting NCT01660308
20 Doppler Ultrasound in Characterization of Superficial Soft Tissue Masses Not yet recruiting NCT03171857

Search NIH Clinical Center for Mesenchymal Cell Neoplasm

Genetic Tests for Mesenchymal Cell Neoplasm

Anatomical Context for Mesenchymal Cell Neoplasm

MalaCards organs/tissues related to Mesenchymal Cell Neoplasm:

38
Bone, Liver

Publications for Mesenchymal Cell Neoplasm

Articles related to Mesenchymal Cell Neoplasm:

# Title Authors Year
1
A spontaneous mesenchymal cell neoplasm in the adult newt, Diemictylus viridescens. ( 5104322 )
1971

Variations for Mesenchymal Cell Neoplasm

Expression for Mesenchymal Cell Neoplasm

Search GEO for disease gene expression data for Mesenchymal Cell Neoplasm.

Pathways for Mesenchymal Cell Neoplasm

GO Terms for Mesenchymal Cell Neoplasm

Cellular components related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle thin filament tropomyosin GO:0005862 8.62 TPM3 TPM4

Biological processes related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.5 FGF23 KIT PDGFRA
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 ALK KIT PDGFRA
3 phosphatidylinositol phosphorylation GO:0046854 9.33 FGF23 KIT PDGFRA
4 positive regulation of phospholipase C activity GO:0010863 8.96 KIT PDGFRA
5 peptidyl-tyrosine phosphorylation GO:0018108 8.92 ALK FGF23 KIT PDGFRA

Molecular functions related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 FGF23 KIT PDGFRA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF23 KIT PDGFRA
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ALK KIT PDGFRA
4 protein tyrosine kinase activity GO:0004713 8.92 ALK FGF23 KIT PDGFRA

Sources for Mesenchymal Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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