MCID: MSN004
MIFTS: 35

Mesenchymal Cell Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Cell Neoplasm

MalaCards integrated aliases for Mesenchymal Cell Neoplasm:

Name: Mesenchymal Cell Neoplasm 12 14 69
Benign Miscellaneous Mesenchymal Tumor 12
Mesenchymal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3350
NCIt 47 C6587 C7059

Summaries for Mesenchymal Cell Neoplasm

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

MalaCards based summary : Mesenchymal Cell Neoplasm, also known as benign miscellaneous mesenchymal tumor, is related to gastrointestinal stromal tumor and sarcoma. An important gene associated with Mesenchymal Cell Neoplasm is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The drugs Fentanyl and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and bone marrow, and related phenotype is neoplasm.

Related Diseases for Mesenchymal Cell Neoplasm

Diseases related to Mesenchymal Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 gastrointestinal stromal tumor 31.4 CD34 KIT PDGFRA
2 sarcoma 30.6 CREB3L2 KIT
3 mediastinal mesenchymal tumor 11.8
4 oncogenic osteomalacia 11.2
5 vaginal carcinosarcoma 11.0
6 malignant mesenchymoma 11.0
7 inflammatory myofibroblastic tumor 10.9
8 gallbladder sarcoma 10.8
9 central nervous system mesenchymal non-meningothelial tumor 10.8
10 ovarian carcinosarcoma 10.8
11 fetal lung interstitial tumor 10.8
12 paraganglioma and gastric stromal sarcoma 10.8
13 carney triad 10.8
14 myoma 10.8
15 dedifferentiated liposarcoma 10.7 KIT PDGFRA
16 movement disease 10.7 KIT PDGFRA
17 retroperitoneal leiomyosarcoma 10.7 KIT PDGFRA
18 wilms tumor 6 10.7 KIT PDGFRA
19 desmoplastic small round cell tumor 10.7 KIT PDGFRA
20 mercaptolactate-cysteine disulfiduria 10.7 KIT PDGFRA
21 sarcomatoid mesothelioma 10.6 KIT PDGFRA
22 cerebral arterial disease 10.6 CLTC TPM3
23 thymus small cell carcinoma 10.6 KIT PDGFRA
24 punctate palmoplantar keratoderma type 2 10.6 KIT PDGFRA
25 breast adenoid cystic carcinoma 10.6 ALK KIT PDGFRA
26 lung benign neoplasm 10.5 EWSR1 SMARCB1
27 hypoglossal nerve neoplasm 10.5 KIT PDGFRA SMARCB1
28 thymus large cell carcinoma 10.5 EWSR1 SMARCB1
29 alopecia antibody deficiency 10.5 KIT PDGFRA TPM3
30 extragonadal nonseminomatous germ cell tumor 10.5 ALK KIT
31 alcohol-induced mental disorder 10.5 HBA1 KIT
32 bile duct rhabdomyosarcoma 10.4 KIT MYOD1
33 botryoid rhabdomyosarcoma 10.4 KIT MYOD1
34 multilocular clear cell renal cell carcinoma 10.3 ALK TPM3
35 lung leiomyosarcoma 10.3 CREB3L2 KIT PDGFRA
36 appendix leiomyoma 10.3 CD34 KIT
37 extraosseous osteosarcoma 10.3 CREB3L2 KIT PDGFRA
38 small intestine leiomyosarcoma 10.3 CD34 KIT
39 liver inflammatory pseudotumor 10.2 CD34 KIT
40 osteomalacia 10.2
41 anus leiomyoma 10.2 CD34 KIT
42 filamentary keratitis 10.2 CD34 KIT
43 malignant dermis tumor 10.2 CD34 KIT
44 gallbladder leiomyosarcoma 10.2 CD34 KIT
45 breast leiomyosarcoma 10.2 CD34 KIT
46 pericoronitis 10.2 CD34 KIT
47 fallopian tube squamous cell carcinoma 10.2 CD34 KIT
48 exertional headache 10.1 EWSR1 KIT
49 cholelithiasis 10.1 CREB3L2 HBA1
50 thyroid cancer, nonmedullary, 4 10.1 CREB3L2 EWSR1 SMARCB1

Graphical network of the top 20 diseases related to Mesenchymal Cell Neoplasm:



Diseases related to Mesenchymal Cell Neoplasm

Symptoms & Phenotypes for Mesenchymal Cell Neoplasm

MGI Mouse Phenotypes related to Mesenchymal Cell Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ALK CD34 KIT MYOD1 PDGFRA SMARCB1

Drugs & Therapeutics for Mesenchymal Cell Neoplasm

Drugs for Mesenchymal Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Anesthetics Phase 3,Phase 2,Phase 1
5 Liver Extracts Phase 3,Phase 1,Phase 2
6 Immunosuppressive Agents Phase 3,Phase 1,Phase 2,Early Phase 1
7 Adjuvants, Anesthesia Phase 3
8 Analgesics Phase 3,Phase 2,Phase 1
9 Analgesics, Opioid Phase 3
10 Anesthetics, General Phase 3
11 Anesthetics, Intravenous Phase 3
12 Central Nervous System Depressants Phase 3
13 Narcotics Phase 3
14 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
15 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
17 Cola Nutraceutical Phase 3
18
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
19
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
20
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
21
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
22
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
23
Dactinomycin Approved Phase 2 50-76-0 2019 457193
24
Epirubicin Approved Phase 2 56420-45-2 41867
25
Etoposide Approved Phase 2 33419-42-0 36462
26
Ifosfamide Approved Phase 2 3778-73-2 3690
27
Lenograstim Approved Phase 2,Phase 1 135968-09-1
28
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
29
ponatinib Approved Phase 2 943319-70-8 24826799
30
Nintedanib Approved Phase 2 656247-17-5 56843413
31
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Prednisone Approved, Vet_approved Phase 2,Phase 1 53-03-2 5865
34
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
35
Busulfan Approved, Investigational Phase 2,Phase 1 55-98-1 2478
36
Clofarabine Approved, Investigational Phase 2,Phase 1 123318-82-1 119182
37
Fludarabine Approved Phase 2,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
38
Melphalan Approved Phase 2,Phase 1,Early Phase 1 148-82-3 4053 460612
39
rituximab Approved Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
40
Vidarabine Approved Phase 2,Phase 1 24356-66-9 32326 21704
41
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
42
Mesna Approved Phase 2 3375-50-6 598
43
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
44
Pentostatin Approved, Investigational Phase 1, Phase 2 53910-25-1 40926 439693
45
Adefovir Dipivoxil Approved, Investigational Phase 1, Phase 2 142340-99-6 60871
46
Entecavir Approved, Investigational Phase 1, Phase 2 142217-69-4 153941
47
Lamivudine Approved, Investigational Phase 1, Phase 2 134678-17-4 60825
48
Amlodipine Approved Phase 2 88150-42-9 2162
49
Dalteparin Approved Phase 2 9005-49-6
50
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594

Interventional clinical trials:

(show top 50) (show all 87)

id Name Status NCT ID Phase Drugs
1 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease Completed NCT00366145 Phase 3
4 Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients With Hematological Malignancies Recruiting NCT03106662 Phase 3 cyclophosphamide administration
5 Evaluation of PROCHYMAL® Adult Human Stem Cells for Treatment-resistant Moderate-to-severe Crohn's Disease Active, not recruiting NCT00482092 Phase 3 adult human mesenchymal stem cells;Placebo
6 Using Mesenchymal Stem Cells to Fill Bone Void Defects in Patients With Benign Bone Lesions Withdrawn NCT00851162 Phase 2, Phase 3
7 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
8 Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold Unknown status NCT01958502 Phase 2
9 Mesenchymal Stem Cell Transplantation in Decompensated Cirrhosis Unknown status NCT00476060 Phase 2
10 Multicenter Trial With PegLiposomal Doxorubicin and Carboplatin Combination Chemotherapy in Gynecological Sarcomas and Mixed Epithelial-Mesenchymal Tumors Completed NCT00815945 Phase 2 PegLiposomal Doxorubicin;Carboplatin
11 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
12 High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum Completed NCT00592345 Phase 1, Phase 2
13 Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST) Completed NCT01172548 Phase 2 imatinib mesylate
14 A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed NCT01874665 Phase 2 ponatinib
15 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
16 Safety and Efficacy of Repeated Infusion of CELYVIR in Children and Adults With Metastatic and Refractory Tumors. Completed NCT01844661 Phase 1, Phase 2
17 Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-versus-host Disease Completed NCT00504803 Phase 2
18 Mesenchymal Stemcells for Radiation Induced Xerostomia Completed NCT02513238 Phase 2 Mesenchymal stem cell;Isotonic NaCl
19 The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital Completed NCT01788059 Phase 2
20 Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute GVHD. Completed NCT00136903 Phase 2 Prochymal - 2 million cells;Prochymal - 8 million cells
21 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
22 Cell Transplant in Spinal Cord Injury Patients Completed NCT00816803 Phase 1, Phase 2
23 Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells From Adipose Tissue in Patients With Chronic Graft Versus Host Disease. Completed NCT01222039 Phase 1, Phase 2
24 Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting NCT03109301 Phase 2 Selumetinib (AZD6244 hyd sulfate)
25 Mesenchymal Stem Cells (MSCs) for Treatment of Acute Respiratory Distress Syndrome (ARD) in Patients With Malignancies Recruiting NCT02804945 Phase 2
26 MV-NIS Infected Mesenchymal Stem Cells in Treating Patients With Recurrent Ovarian Cancer Recruiting NCT02068794 Phase 1, Phase 2
27 Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery Recruiting NCT02648386 Phase 1, Phase 2
28 Cord Blood (CB) Ex-vivo Mesenchymal Stem Cell (MSC) Expansion + Fucosylation Recruiting NCT03096782 Phase 2 Busulfan;Rituximab;ATG;Fludarabine;Clofarabine;Mycofenolate mofetil;Tacrolimus;G-CSF;Melphalan;Cyclophosphamide;Mesna
29 Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Mesenchymal Stem Cells Recruiting NCT01092026 Phase 1, Phase 2
30 MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs Recruiting NCT02582775 Phase 2 Thymoglobulin;Cyclophosphamide;Fludarabine;Tacrolimus;Mycophenolate Mofetil
31 Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease Recruiting NCT03299413 Phase 1, Phase 2
32 Stem Cell Transplant for Epidermolysis Bullosa Recruiting NCT01033552 Phase 2 Cyclophosphamide;Fludarabine;Anti-thymocyte globulin;Cyclosporine A;Mycophenolate mofetil
33 Mesenchymal Stem Cells as a Treatment for Oral Complications of Graft-versus-host Disease Recruiting NCT02055625 Phase 1, Phase 2
34 Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Women With Primary Ovarian Insufficiency (POI) Recruiting NCT03033277 Phase 1, Phase 2
35 Allogeneic Adipose Derived Stem Cells for Werdnig Hoffman Patients Recruiting NCT02855112 Phase 1, Phase 2
36 Phase 2 Study of MGCD265 in Patients With Non-Small Cell Lung Cancer With Activating Genetic Alterations in MET Recruiting NCT02544633 Phase 2 MGCD265
37 Umbilical Cord Derived Mesenchymal Stromal Cells For The Treatment of Severe Steroid-resistant Graft Versus Host Disease Recruiting NCT02032446 Phase 1, Phase 2
38 Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure Recruiting NCT01844063 Phase 1, Phase 2 Conventional treatment
39 Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Active, not recruiting NCT02015065 Phase 2 Vandetanib
40 Rituximab Combined With MSCs in the Treatment of PNS (3-4 Stage of CKD) Active, not recruiting NCT02966717 Phase 2 Rituximab;conventional therapy;Mesenchymal stem cells
41 Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study Enrolling by invitation NCT02806011 Phase 2
42 Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma Not yet recruiting NCT03123276 Phase 1, Phase 2 Pembrolizumab;Gemcitabine
43 Stem Cell Transplantation in Cirrhotic Patients Not yet recruiting NCT02943889 Phase 1, Phase 2
44 Targeted Stem Cells Expressing TRAIL as a Therapy for Lung Cancer Not yet recruiting NCT03298763 Phase 1, Phase 2 Placebo
45 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
46 Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore) Withdrawn NCT02766842 Phase 2
47 OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing Donor Peripheral Stem Cell Transplantation for Hematologic Malignancies Withdrawn NCT00081055 Phase 2 busulfan;cyclophosphamide;cyclosporine;methotrexate
48 Genetically Modified Mesenchymal Stem Cell Theraopeutic Against Head and Neck Cancer Unknown status NCT02079324 Phase 1
49 Safety Study of Filler Agent Composed of Autologous Mesenchymal Stem Cells and Hyaluronic Acid Unknown status NCT02034786 Phase 1
50 Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD) Unknown status NCT01764100 Phase 1

Search NIH Clinical Center for Mesenchymal Cell Neoplasm

Genetic Tests for Mesenchymal Cell Neoplasm

Anatomical Context for Mesenchymal Cell Neoplasm

MalaCards organs/tissues related to Mesenchymal Cell Neoplasm:

39
Bone, Liver, Bone Marrow, Lung, Prostate, Spinal Cord

Publications for Mesenchymal Cell Neoplasm

Articles related to Mesenchymal Cell Neoplasm:

id Title Authors Year
1
A spontaneous mesenchymal cell neoplasm in the adult newt, Diemictylus viridescens. ( 5104322 )
1971

Variations for Mesenchymal Cell Neoplasm

Expression for Mesenchymal Cell Neoplasm

Search GEO for disease gene expression data for Mesenchymal Cell Neoplasm.

Pathways for Mesenchymal Cell Neoplasm

GO Terms for Mesenchymal Cell Neoplasm

Cellular components related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle thin filament tropomyosin GO:0005862 8.62 TPM3 TPM4

Biological processes related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.54 ALK KIT PDGFRA
2 phosphatidylinositol-mediated signaling GO:0048015 9.5 FGF23 KIT PDGFRA
3 phosphatidylinositol phosphorylation GO:0046854 9.43 FGF23 KIT PDGFRA
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.33 FGF23 KIT PDGFRA
5 positive regulation of phospholipase C activity GO:0010863 8.96 KIT PDGFRA
6 peptidyl-tyrosine phosphorylation GO:0018108 8.92 ALK FGF23 KIT PDGFRA

Molecular functions related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 FGF23 KIT PDGFRA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF23 KIT PDGFRA
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ALK KIT PDGFRA
4 protein tyrosine kinase activity GO:0004713 8.92 ALK FGF23 KIT PDGFRA

Sources for Mesenchymal Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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