MCID: MSN004
MIFTS: 34

Mesenchymal Cell Neoplasm malady

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Cell Neoplasm

Aliases & Descriptions for Mesenchymal Cell Neoplasm:

Name: Mesenchymal Cell Neoplasm 12 14 69
Benign Miscellaneous Mesenchymal Tumor 12
Mesenchymal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3350
NCIt 47 C6587 C7059

Summaries for Mesenchymal Cell Neoplasm

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

MalaCards based summary : Mesenchymal Cell Neoplasm, also known as benign miscellaneous mesenchymal tumor, is related to gastrointestinal stromal tumor and sarcoma. An important gene associated with Mesenchymal Cell Neoplasm is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Glioma and Pathways in cancer. The drugs Cyclophosphamide and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is neoplasm.

Related Diseases for Mesenchymal Cell Neoplasm

Diseases related to Mesenchymal Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 gastrointestinal stromal tumor 31.6 CD34 KIT PDGFRA
2 sarcoma 29.9 CREB3L2 KIT
3 mediastinal mesenchymal tumor 11.8
4 oncogenic osteomalacia 11.2
5 malignant mesenchymoma 11.1
6 vaginal carcinosarcoma 11.0
7 inflammatory myofibroblastic tumor 10.9
8 gallbladder sarcoma 10.8
9 central nervous system mesenchymal non-meningothelial tumor 10.8
10 ovarian carcinosarcoma 10.8
11 fetal lung interstitial tumor 10.8
12 myoma 10.8
13 invasive mole 10.3 KIT PDGFRA
14 ganglioneuroma 10.3 KIT PDGFRA
15 dfnb1 10.3 KIT PDGFRA
16 uremic neuropathy 10.2 KIT PDGFRA
17 kahrizi syndrome 10.2 KIT PDGFRA
18 kidney clear cell sarcoma 10.2 ALK KIT PDGFRA
19 amaurosis congenita, cone-rod type, with congenital hypertrichosis 10.2 KIT PDGFRA
20 osteomalacia 10.2
21 botryoid rhabdomyosarcoma 10.2 KIT MYOD1
22 c-p angle neurinoma 10.2 KIT PDGFRA SMARCB1
23 malignant epithelial mesothelioma 10.2 KIT PDGFRA
24 occlusion precerebral artery 10.2 KIT PDGFRA SMARCB1
25 hyperandrogenism due to cortisone reductase deficiency 10.2 KIT PDGFRA TPM3
26 neurofibroma of gallbladder 10.2 CD34 KIT
27 gallbladder leiomyosarcoma 10.2 CD34 KIT
28 speech disorder 10.2 CD34 KIT
29 leiomyomatosis 10.2 CD34 KIT
30 diarrhea, chronic, with villous atrophy 10.2 FGF23 HBA1 KIT
31 freemartinism 10.2 CD34 KIT
32 olfactory nerve disease 10.2 KIT PDGFRA
33 gastric leiomyosarcoma 10.2 CD34 KIT
34 prostate leiomyosarcoma 10.2 CD34 KIT
35 orbit embryonal rhabdomyosarcoma 10.2 KIT MYOD1
36 ectopic pregnancy 10.2 HBA1 MYOD1
37 uterus leiomyosarcoma 10.1 CD34 KIT
38 larynx leiomyosarcoma 10.1 KIT PDGFRA
39 pleomorphic adenoma 10.1 CD34 HBA1
40 rhabdoid cancer 10.1 CD34 KIT
41 basophil adenoma 10.1 CD34 HBA1
42 ovarian lymphoma 10.1 CD34 HBA1
43 dermoid cyst 10.1 CD34 HBA1
44 thyroid angiosarcoma 10.1 CD34 HBA1
45 cervix endometrial stromal tumor 10.1 CD34 HBA1
46 vulvar dystrophy 10.1 CD34 HBA1
47 hemopneumothorax 10.1 CD34 HBA1
48 choriocarcinoma of ovary 10.1 CD34 KIT
49 superior vena cava angiosarcoma 10.1 CD34 HBA1
50 lice infestation 10.1 CD34 KIT SMARCB1

Graphical network of the top 20 diseases related to Mesenchymal Cell Neoplasm:



Diseases related to Mesenchymal Cell Neoplasm

Symptoms & Phenotypes for Mesenchymal Cell Neoplasm

MGI Mouse Phenotypes related to Mesenchymal Cell Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ALK CD34 KIT MYOD1 PDGFRA SMARCB1

Drugs & Therapeutics for Mesenchymal Cell Neoplasm

Drugs for Mesenchymal Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 175)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3, Phase 1 50-18-0, 6055-19-2 2907
2
Ifosfamide Approved Phase 2, Phase 3,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved Phase 2, Phase 3,Phase 1 51-75-2 4033
4
Cisplatin Approved Phase 3,Phase 1,Phase 2 15663-27-1 84093 441203 2767
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
7
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
8
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
9
Capecitabine Approved, Investigational Phase 3,Phase 1 154361-50-9 60953
10
Fluorouracil Approved Phase 3 51-21-8 3385
11
Doxil Approved June 1999 Phase 2, Phase 3 31703
12 Alkylating Agents Phase 2, Phase 3, Phase 1, Early Phase 1
13 Antineoplastic Agents, Alkylating Phase 2, Phase 3, Phase 1, Early Phase 1
14 Antirheumatic Agents Phase 2, Phase 3, Phase 1, Early Phase 1
15 Immunosuppressive Agents Phase 2, Phase 3, Phase 1, Early Phase 1
16 Anesthetics Phase 3,Phase 2,Phase 1
17 Liver Extracts Phase 3,Phase 1,Phase 2
18 Anti-Bacterial Agents Phase 2, Phase 3, Phase 1
19 Isophosphamide mustard Phase 2, Phase 3,Phase 1
20 Antibodies Phase 3,Phase 1,Phase 2
21 Immunoglobulins Phase 3,Phase 1,Phase 2
22 Mitogens Phase 3,Phase 1,Phase 2
23 Adjuvants, Anesthesia Phase 3
24 Analgesics Phase 3,Phase 2,Phase 1
25 Analgesics, Opioid Phase 3
26 Anesthetics, General Phase 3
27 Anesthetics, Intravenous Phase 3
28 Central Nervous System Depressants Phase 3
29 Narcotics Phase 3
30 pancreatic polypeptide Phase 3
31 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
32 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 1
33 Gastrointestinal Agents Phase 2, Phase 3
34 Antibiotics, Antitubercular Phase 2, Phase 3, Phase 1
35 Topoisomerase Inhibitors Phase 2, Phase 3
36 Antimetabolites Phase 3,Phase 1,Phase 2,Early Phase 1
37 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2,Early Phase 1
38 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
39 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 1
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 1
41 Immunoglobulin G Phase 3,Phase 1
42 Antibodies, Monoclonal Phase 3,Phase 2
43 Cola Nutraceutical Phase 3,Phase 2
44
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
45
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
46
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
47
Cyclosporine Approved, Investigational, Vet_approved Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
48
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
49
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
50
Mesna Approved Phase 1, Phase 2 3375-50-6 598

Interventional clinical trials:

(show top 50) (show all 133)
id Name Status NCT ID Phase
1 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
2 MSC and Cyclophosphamide for Acute Graft-Versus-Host Disease (aGVHD) Prophylaxis Unknown status NCT02270307 Phase 2, Phase 3
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
4 Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease Completed NCT00366145 Phase 3
5 Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients With Hematological Malignancies Recruiting NCT03106662 Phase 3
6 A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis Recruiting NCT02809781 Phase 2, Phase 3
7 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
8 A Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients Who Have Failed to Respond to Steroid Treatment for Acute GVHD Recruiting NCT02336230 Phase 3
9 Evaluation of PROCHYMAL® Adult Human Stem Cells for Treatment-resistant Moderate-to-severe Crohn's Disease Active, not recruiting NCT00482092 Phase 3
10 P3 Study of Umbilical Cord Blood Cells Expanded With MPCs for Transplantation in Patients With Hematologic Malignancies Active, not recruiting NCT01854567 Phase 3
11 A Phase 3 Study of Rilotumumab (AMG 102) With Cisplatin and Capecitabine (CX) as First-line Therapy in Gastric Cancer Terminated NCT02137343 Phase 3
12 First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma Terminated NCT01697072 Phase 3
13 Using Mesenchymal Stem Cells to Fill Bone Void Defects in Patients With Benign Bone Lesions Withdrawn NCT00851162 Phase 2, Phase 3
14 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
15 Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold Unknown status NCT01958502 Phase 2
16 Mesenchymal Stem Cell Transplantation in Decompensated Cirrhosis Unknown status NCT00476060 Phase 2
17 Umbilical Cord Mesenchymal Stem Cells for Immune Reconstitution in HIV-infected Patients Unknown status NCT01213186 Phase 2
18 Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Myelodysplastic Syndromes Unknown status NCT01129739 Phase 2
19 Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma Unknown status NCT01534585 Phase 1, Phase 2
20 Phase I-II Trial of Sorafenib in Combination With Ifosfamide in Soft Tissue Sarcoma Unknown status NCT00541840 Phase 1, Phase 2
21 Multicenter Trial With PegLiposomal Doxorubicin and Carboplatin Combination Chemotherapy in Gynecological Sarcomas and Mixed Epithelial-Mesenchymal Tumors Completed NCT00815945 Phase 2
22 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
23 High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum Completed NCT00592345 Phase 1, Phase 2
24 Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST) Completed NCT01172548 Phase 2
25 A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed NCT01874665 Phase 2
26 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2
27 Safety and Efficacy of Repeated Infusion of CELYVIR in Children and Adults With Metastatic and Refractory Tumors. Completed NCT01844661 Phase 1, Phase 2
28 Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-versus-host Disease Completed NCT00504803 Phase 2
29 Mesenchymal Stemcells for Radiation Induced Xerostomia Completed NCT02513238 Phase 2
30 The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital Completed NCT01788059 Phase 2
31 Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute GVHD. Completed NCT00136903 Phase 2
32 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
33 Cell Transplant in Spinal Cord Injury Patients Completed NCT00816803 Phase 1, Phase 2
34 Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells From Adipose Tissue in Patients With Chronic Graft Versus Host Disease. Completed NCT01222039 Phase 1, Phase 2
35 A Study Assessing Efficacy and Safety of SAR125844 in NSCLC Patients With MET Amplification Completed NCT02435121 Phase 2
36 Lapatinib Ditosylate, Trastuzumab, Paclitaxel, and Surgery in Treating Patients With Breast Cancer Completed NCT01688609 Phase 2
37 Gemcitabine Plus Rapamycin Versus Gemcitabine to Treat Advanced Soft Tissue Sarcoma Completed NCT01684449 Phase 1, Phase 2
38 Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting NCT03109301 Phase 2
39 MV-NIS Infected Mesenchymal Stem Cells in Treating Patients With Recurrent Ovarian Cancer Recruiting NCT02068794 Phase 1, Phase 2
40 Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery Recruiting NCT02648386 Phase 1, Phase 2
41 Mesenchymal Stem Cells (MSCs) for Treatment of Acute Respiratory Distress Syndrome (ARD) in Stem Cell Transplant Patients Recruiting NCT02804945 Phase 2
42 Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Mesenchymal Stem Cells Recruiting NCT01092026 Phase 1, Phase 2
43 MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs Recruiting NCT02582775 Phase 2
44 Stem Cell Transplant for Epidermolysis Bullosa Recruiting NCT01033552 Phase 2
45 Mesenchymal Stem Cells as a Treatment for Oral Complications of Graft-versus-host Disease Recruiting NCT02055625 Phase 1, Phase 2
46 Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Women With Primary Ovarian Insufficiency (POI) Recruiting NCT03033277 Phase 1, Phase 2
47 Allogeneic Adipose Derived Stem Cells for Werdnig Hoffman Patients Recruiting NCT02855112 Phase 1, Phase 2
48 Phase 2 Study of MGCD265 in Patients With Non-Small Cell Lung Cancer With Activating Genetic Alterations in MET Recruiting NCT02544633 Phase 2
49 Umbilical Cord Derived Mesenchymal Stromal Cells For The Treatment of Severe Steroid-resistant Graft Versus Host Disease Recruiting NCT02032446 Phase 1, Phase 2
50 Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure Recruiting NCT01844063 Phase 1, Phase 2

Search NIH Clinical Center for Mesenchymal Cell Neoplasm

Genetic Tests for Mesenchymal Cell Neoplasm

Anatomical Context for Mesenchymal Cell Neoplasm

MalaCards organs/tissues related to Mesenchymal Cell Neoplasm:

39
Bone

Publications for Mesenchymal Cell Neoplasm

Articles related to Mesenchymal Cell Neoplasm:

id Title Authors Year
1
A spontaneous mesenchymal cell neoplasm in the adult newt, Diemictylus viridescens. ( 5104322 )
1971

Variations for Mesenchymal Cell Neoplasm

Expression for Mesenchymal Cell Neoplasm

Search GEO for disease gene expression data for Mesenchymal Cell Neoplasm.

Pathways for Mesenchymal Cell Neoplasm

GO Terms for Mesenchymal Cell Neoplasm

Cellular components related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle thin filament tropomyosin GO:0005862 8.62 TPM3 TPM4

Biological processes related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.54 ALK KIT PDGFRA
2 phosphatidylinositol-mediated signaling GO:0048015 9.5 FGF23 KIT PDGFRA
3 phosphatidylinositol phosphorylation GO:0046854 9.43 FGF23 KIT PDGFRA
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.33 FGF23 KIT PDGFRA
5 positive regulation of phospholipase C activity GO:0010863 8.96 KIT PDGFRA
6 peptidyl-tyrosine phosphorylation GO:0018108 8.92 ALK FGF23 KIT PDGFRA

Molecular functions related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 FGF23 KIT PDGFRA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF23 KIT PDGFRA
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ALK KIT PDGFRA
4 protein tyrosine kinase activity GO:0004713 8.92 ALK FGF23 KIT PDGFRA

Sources for Mesenchymal Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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