MCID: MSN005
MIFTS: 50

Mesenchymal Chondrosarcoma malady

Summaries for Mesenchymal Chondrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and osteosarcoma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Striated Muscle Contraction and Neural Crest Differentiation. The compounds orcein and creatinine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

mesenchymal chondrosarcoma 8 10
chondrosarcoma, mesenchymal 60
chondrosarcoma mesenchymal 44


External Ids:

Disease Ontology8 DOID:4545
MeSH34 D018211
SNOMED-CT56 56565002
NCIt39 C3737

Related Diseases for Mesenchymal Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.9MUC1, DES, SOX9, S100B, VIM
2osteosarcoma30.3MYOD1, SOX9
3sarcoma30.3VIM, S100B, SMARCB1, ACTC1, MUC1, MYOG
4hemangiopericytoma30.1VIM, S100B, DES, MUC1, ACTC1
5extraskeletal mesenchymal chondrosarcoma10.9
6intracranial chondrosarcoma10.7
7pediatric mesenchymal chondrosarcoma10.5
8adult mesenchymal chondrosarcoma10.5
9meningitis10.5
10cervicitis10.3
11osteomalacia10.2
12small cell sarcoma10.2
13chondroblastoma10.1
14fibrous dysplasia10.1
15meninges hemangiopericytoma10.1
16bone osteosarcoma10.1
17chondroma10.1
18extraosseous chondrosarcoma10.1
19keratoacanthoma10.1
20mesenchymal cell neoplasm10.1
21myxoid chondrosarcoma10.1
22periodontitis10.1
23thyroiditis10.1
24infantile myofibromatosis10.0DES
25fasciitis10.0ACTC1
26papilloma10.0ACTC1
27lymphangioleiomyomatosis10.0DES
28hemangioma10.0ACTC1
29alveolar soft part sarcoma10.0MYOD1
30atypical teratoid rhabdoid tumor10.0SMARCB1
31sertoli-leydig cell tumor10.0MUC1
32rhabdoid cancer10.0SMARCB1
33lipoma10.0DES
34gliosarcoma10.0GFAP
35giant cell glioblastoma10.0GFAP
36collecting duct carcinoma10.0SMARCB1
37pierre robin sequence10.0SOX9
38subependymal giant cell astrocytoma10.0GFAP
39cystadenocarcinoma10.0MUC1
40retroperitoneal leiomyosarcoma10.0SMARCB1
41malignant mesenchymoma10.0MYOD1, MYOG
42mixed glioma10.0GFAP
43histiocytosis10.0S100B
44fibrous meningioma10.0S100B, MUC1
45congenital mesoblastic nephroma10.0SMARCB1
46adenomatoid tumor10.0VIM
47myotonic dystrophy10.0MYOD1, MYOG
48desmoplastic small round cell tumor10.0MUC1, DES
49ganglioglioma10.0S100B, GFAP
50pineocytoma10.0GFAP, S100B

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Clinical Features for Mesenchymal Chondrosarcoma

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Drugs & Therapeutics for Mesenchymal Chondrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mesenchymal Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Search CenterWatch for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

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Anatomical Context for Mesenchymal Chondrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

32
Bone, Lung, Kidney, Pancreas, Cerebellum, Heart, Breast, Spinal cord, Brain, Spleen, Thyroid, Skin

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1HEY1, SOX9, MYOD1, GFAP, ACTC1
2MP:00053818.6COL2A1, SOX9, MUC1, CDX1, GFAP, SMARCB1
3MP:00053918.3COL2A1, VIM, SOX9, MUC1, GFAP, SMARCB1
4MP:00053857.9COL2A1, VIM, HEY1, SOX9, DES, MYOD1
5MP:00053807.7COL2A1, VIM, HEY1, SOX9, NCOA2, MYOG
6MP:00053867.6COL2A1, VIM, S100B, SOX9, DES, NCOA2
7MP:00053767.4SOX9, DES, MYOD1, MYOG, MUC1, GFAP
8MP:00028737.4ACTC1, COL2A1, S100B, HEY1, SOX9, MYOD1
9MP:00107687.3SOX9, HEY1, VIM, COL2A1, DES, MYOD1
10MP:00053787.0COL2A1, VIM, HEY1, SOX9, NCOA2, MYOD1

Publications for Mesenchymal Chondrosarcoma

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50PubMed
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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 269)
idTitleAuthorsYear
1
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
2
Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma. (23185413)
2012
3
Mesenchymal chondrosarcoma of the orbit. (22489856)
2012
4
Mesenchymal chondrosarcoma of the orbit--case report. (23095269)
2012
5
Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. (22726976)
2012
6
Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. (22034177)
2012
7
Intramuscular, extraskeletal mesenchymal chondrosarcoma. (23548257)
2011
8
Mesenchymal chondrosarcoma of the cervical spine: A case report. (23393533)
2011
9
Primary spinal dumbbell-shaped mesenchymal chondrosarcoma located intradurally and extradurally. (22259697)
2011
10
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. (21598255)
2011
11
Case report: Mesenchymal chondrosarcoma of the lumbar spine in a child. (20300902)
2010
12
Mesenchymal chondrosarcoma of the orbit: an unusual site for a rare tumour. (19686354)
2010
13
An unusual case of primary mesenchymal chondrosarcoma in orbit with intracranial extension. (20813303)
2010
14
Primary mesenchymal chondrosarcoma of the breast. (19136810)
2009
15
Mesenchymal chondrosarcoma of the orbit: a unique radiologic-pathologic correlation. (19454935)
2009
16
Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma. (20847886)
2009
17
Primary spinal intradural mesenchymal chondrosarcoma. A pediatric case report. (18243318)
2008
18
Mesenchymal chondrosarcoma of the lung]. (18727434)
2008
19
Mesenchymal chondrosarcoma of the maxilla: case report and literature review. (17517320)
2007
20
Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. (18038872)
2007
21
Primary intradural mesenchymal chondrosarcoma of the spine in a child. (17849111)
2007
22
Extraskeletal mesenchymal chondrosarcoma of the heart responded to systemic chemotherapy: a case report. (19746223)
2007
23
Desmin and myogenin reactivity in mesenchymal chondrosarcoma: a potential diagnostic pitfall. (16405671)
2006
24
Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat. (15842543)
2005
25
Extraskeletal intracranial mesenchymal chondrosarcoma: case report and literature review. (15233236)
2004
26
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. (12817616)
2003
27
Mesenchymal chondrosarcoma of the sellar region. (12910404)
2003
28
Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case. (12700920)
2003
29
Pathology quiz case 1. Mesenchymal chondrosarcoma of the left maxillary sinus. (12365899)
2002
30
Mesenchymal chondrosarcoma of the maxilla. (12239076)
2002
31
Mesenchymal chondrosarcoma of the vagus nerve. (12389698)
2002
32
Mesenchymal chondrosarcoma of the orbit: a clinicopathological study. (12045935)
2001
33
Mesenchymal chondrosarcoma of the sacrum: a case report and review of the literature. (10778771)
2000
34
Mesenchymal chondrosarcoma of the maxilla: report of a case. (10368101)
1999
35
"Mesenchymal chondrosarcoma of the retroperitoneum". (9434834)
1998
36
Mesenchymal chondrosarcoma of the jaw--report of a case and review of 41 cases in the literature. (8407320)
1993
37
Case report 788: Mesenchymal chondrosarcoma of the soft tissue of the left foot. (8316876)
1993
38
Mesenchymal chondrosarcoma--a case report. (1512724)
1992
39
Case report: primary mesenchymal chondrosarcoma of the brain. (1606805)
1992
40
View from beneath--pathology in focus. Primary intracranial mesenchymal chondrosarcoma. (2754330)
1989
41
Mesenchymal chondrosarcoma. (3104490)
1987
42
Mesenchymal chondrosarcoma in the young. (6402853)
1983
43
Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. (6825046)
1983
44
Mesenchymal chondrosarcoma: a report of 17 cases. (7273513)
1981
45
Mesenchymal chondrosarcoma of the soft tissues. (7347729)
1981
46
Primary meningeal mesenchymal chondrosarcoma. (582258)
1979
47
Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. (365318)
1978
48
Mesenchymal chondrosarcoma of the rectus sheath case report with ultrasonic findings. (144144)
1977
49
Mesenchymal chondrosarcoma--report of four cases. (1184071)
1975
50
MESENCHYMAL CHONDROSARCOMA. (14161087)
1964

Genetic Variations for Mesenchymal Chondrosarcoma

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Expression for genes affiliated with Mesenchymal Chondrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Mesenchymal Chondrosarcoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1orcein449.8VIM, ACTC1, DES, S100B
2creatinine449.8GFAP, MYOD1, ACTC1
3procollagen449.7COL2A1, VIM, DES, ACTC1
4ganglioside449.7DES, GFAP, VIM
5biotin44 11 2411.7VIM, MUC1, ACTC1, DES
6eosin449.6VIM, GFAP, MUC1, S100B
7dbc-amp449.6VIM, GFAP, S100B
8acetylcholine44 49 28 11 2413.6MYOG, MYOD1, GFAP
9butyrate449.5MYOG, GFAP, MYOD1
10mucicarmine449.5ACTC1, VIM, MUC1, DES, S100B
11b 723449.5S100B, VIM, DES, MUC1, ACTC1
12matrigel449.4GFAP, ACTC1, MUC1, VIM
13chondroitin sulfate44 2410.4SOX9, VIM, GFAP
144-hydroxytamoxifen449.4NCOA2, S100B, VIM
15ribonucleic acid449.4SOX9, MYOG, MUC1, ACTC1
16ascorbic acid44 2410.3S100B, MYOG, COL2A1, SOX9
17ethanol44 49 11 2412.3GFAP, MUC1, DES, S100B
18iron44 2410.3GFAP, ACTC1, DES, S100B, VIM
19dihydrotestosterone44 28 11 2412.3NCOA2, DES, MUC1, VIM
20progestin449.3DES, MUC1, VIM
21methionine449.3VIM, DES, S100B, GFAP
22s 100449.2S100B, DES, MUC1, GFAP, ACTC1, VIM
23reticulin449.2MUC1, ACTC1, GFAP, DES, S100B, VIM
24hematoxylin449.1MUC1, DES, ACTC1, VIM, S100B, GFAP
25formaldehyde44 2410.1S100B, ACTC1, GFAP, MUC1, DES, VIM
26glycogen44 2410.1GFAP, VIM, S100B, DES, MUC1, ACTC1
27chloramphenicol44 2 1111.1MYOD1, COL2A1, VIM, MUC1, S100B
28forskolin44 49 1111.0S100B, GFAP, MUC1, VIM, MYOG
29adenylate449.0GFAP, MYOG, DES, VIM, S100B
3012-o-tetradecanoylphorbol 13-acetate448.9MYOG, MUC1, VIM, MYOD1, DES
31glutamine448.9VIM, S100B, SOX9, NCOA2, GFAP
32estradiol44 11 2410.9NCOA2, GFAP, VIM, DES, MUC1
33bromodeoxyuridine448.7MYOG, GFAP, DES, S100B, VIM, MYOD1
34lysine448.7COL2A1, VIM, DES, NCOA2, MYOD1
35steroid448.5NCOA2, SOX9, MYOD1, MYOG, ACTC1, DES
36progesterone44 59 28 11 2412.5NCOA2, S100B, GFAP, ACTC1, VIM, DES
37zinc44 249.5SOX9, S100B, NCOA2, MYOD1, COL2A1, GFAP
38arginine448.2S100B, GFAP, VIM, NCOA2, MYOD1, COL2A1
39dexamethasone44 49 28 1111.2ACTC1, GFAP, MUC1, NCOA2, SOX9, VIM
40paraffin448.2S100B, VIM, MYOD1, MYOG, MUC1, GFAP
41cysteine448.1COL2A1, VIM, MYOG, DES, MUC1, GFAP
42cyclic amp44 249.0GFAP, MUC1, MYOD1, NCOA2, DES, SOX9
43oxygen44 249.0ACTC1, GFAP, MUC1, MYOG, MYOD1, DES
44vegf447.9GFAP, MYOD1, MYOG, MUC1, ACTC1, DES
45glucose447.9DES, MYOG, S100B, NCOA2, MYOD1, GFAP
46serine447.8VIM, DES, SOX9, S100B, GFAP, MUC1
47tyrosine447.8GFAP, MYOD1, DES, S100B, MUC1, MYOG
48estrogen447.5S100B, VIM, DES, MYOD1, NCOA2, MYOG
49testosterone44 59 11 2410.3ACTC1, SOX9, VIM, S100B, DES, NCOA2
50retinoic acid44 247.6COL2A1, VIM, S100B, SOX9, DES, MYOG

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

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16Gene Ontology
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Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3GFAP, SYNM, DES, VIM

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.2SOX9, HEY1
2notochord developmentGO:03090310.1COL2A1, SOX9
3limb bud formationGO:06017410.0COL2A1, SOX9
4Bergmann glial cell differentiationGO:06002010.0VIM, GFAP
5tissue homeostasisGO:00189410.0SOX9, COL2A1
6astrocyte developmentGO:0140029.9GFAP, VIM
7muscle filament slidingGO:0300499.8ACTC1, DES, VIM
8intermediate filament organizationGO:0451099.8VIM, GFAP
9muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
10skeletal muscle fiber developmentGO:0487419.4MYOG, MYOD1
11cellular response to estradiol stimulusGO:0713929.2MYOG, MYOD1
12positive regulation of transcription from RNA polymerase II promoterGO:0459447.9SMARCB1, CDX1, MYOG, MYOD1, NCOA2, SOX9

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0GFAP, SYNM, DES, VIM
2protein bindingGO:0055155.9S100B, HEY1, SOX9, DES, NCOA2, SYNM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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Sources for Mesenchymal Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet