MCID: MSN005
MIFTS: 45

Mesenchymal Chondrosarcoma malady

Summaries for Mesenchymal Chondrosarcoma

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Wikipedia:63 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards based summary: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and fibroma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Striated Muscle Contraction. The compounds orcein and biotin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are vision/eye and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
See all sources

Mesenchymal Chondrosarcoma, Aliases & Descriptions:

Name: Mesenchymal Chondrosarcoma 9 11
Chondrosarcoma, Mesenchymal 60
 
Chondrosarcoma Mesenchymal 43


External Ids:

Disease Ontology9 DOID:4545
NCIt38 C3737
SNOMED-CT55 56565002
MeSH33 D018211

Related Diseases for Mesenchymal Chondrosarcoma

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Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.7S100B, MUC1, VIM, SOX9, DES
2fibroma30.3DES, VIM, ACTC1
3ewing sarcoma29.9DES, VIM, MYOD1, MYOG, S100B
4hemangiopericytoma29.8DES, VIM, MUC1, ACTC1, S100B
5sarcoma29.3DES, SMARCB1, VIM, MYOD1, MYOG, MUC1
6extraskeletal mesenchymal chondrosarcoma11.0
7infantile myofibromatosis10.6DES
8alveolar soft-part sarcoma10.5MYOD1
9meningitis10.5
10fasciitis10.5ACTC1
11adult mesenchymal chondrosarcoma10.5
12hidradenoma10.4MUC1
13retroperitoneal leiomyosarcoma10.4SMARCB1
14subependymal giant cell astrocytoma10.4GFAP
15cystadenocarcinoma10.4MUC1
16pediatric mesenchymal chondrosarcoma10.4
17giant cell glioblastoma10.4GFAP
18congenital mesoblastic nephroma10.4SMARCB1
19myoma10.4DES, MYOG
20malignant mesenchymoma10.4MYOD1, MYOG
21mixed glioma10.4GFAP
22sarcoma, synovial10.4SSX1
23desmoplastic small round cell tumor10.4MUC1, DES
24cervicitis10.4
25desmoid disease, hereditary10.4DES, ACTC1
26fibrous meningioma10.4S100B, MUC1
27histiocytosis10.3S100B
28adenosarcoma10.3ACTC1, DES
29alexander disease10.3DES, GFAP
30myopathy congenital10.3MYOG, DES
31rhabdomyosarcoma 2, alveolar10.3DES, MYOD1, MYOG
32adenomatoid tumor10.3VIM
33osteomalacia10.3
34thyroiditis10.3
35pineocytoma10.3GFAP, S100B
36cutaneous fibrous histiocytoma10.3DES, ACTC1, S100B
37neurilemmoma10.3SMARCB1, GFAP
38ganglioglioma10.3S100B, GFAP
39myxopapillary ependymoma10.2S100B, GFAP
40papillary ependymoma10.2S100B, GFAP
41choroid plexus carcinoma10.2S100B, GFAP
42gemistocytic astrocytoma10.2GFAP, S100B
43neuroendocrine tumor10.2S100B, SYNM, MUC1
44tubular adenocarcinoma10.2ACTC1, MUC1
45embryonal rhabdomyosarcoma10.2ACTC1, MYOG, MYOD1, DES
46myopathy10.2DES, MYOD1, MYOG, SYNM
47campomelic dysplasia10.2COL2A1, SOX9
48syringoma10.1S100B, MUC1, GFAP
49achondroplasia10.1COL2A1, SOX9
50mucoepidermoid carcinoma10.1MUC1, ACTC1

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Symptoms for Mesenchymal Chondrosarcoma

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Drugs & Therapeutics for Mesenchymal Chondrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

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Anatomical Context for Mesenchymal Chondrosarcoma

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MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

31
Bone, Kidney, Lung, Pancreas, Cerebellum, Heart, Thyroid, Spleen, Brain, Spinal cord, Breast, Skin, Uterus

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5COL2A1, MUC1, VIM, SOX9, GFAP, SMARCB1
2MP:00053818.4SMARCB1, GFAP, SOX9, MUC1, COL2A1, CDX1
3MP:00053697.8DES, GFAP, SOX9, HEY1, VIM, MYOD1
4MP:00053857.6DES, SMARCB1, GFAP, SOX9, HEY1, VIM
5MP:00053807.5SMARCB1, SOX9, HEY1, VIM, MYOG, COL2A1
6MP:00028737.3CDX1, GFAP, SOX9, HEY1, MYOD1, MYOG
7MP:00053767.2DES, SMARCB1, GFAP, SOX9, VIM, MYOD1
8MP:00053867.1DES, GFAP, SOX9, VIM, MYOG, COL2A1
9MP:00107687.0SOX9, GFAP, SMARCB1, DES, HEY1, VIM
10MP:00053786.4SMARCB1, GFAP, SOX9, HEY1, VIM, MYOD1

Publications for Mesenchymal Chondrosarcoma

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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
Primary spinal intradural mesenchymal chondrosarcoma with detection of fusion gene HEY1-NCOA2: A paediatric case report and review of the literature. (25202377)
2014
2
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
3
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. (24255641)
2013
4
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
5
Intraparenchymal mesenchymal chondrosarcoma in an unusual location. (22406804)
2012
6
Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. (21615516)
2012
7
Primary mesenchymal chondrosarcoma of the kidney with synchronous implant and infiltrating urothelial carcinoma of the ureter. (22999069)
2012
8
Mesenchymal chondrosarcoma of the orbit: CT and MRI findings. (22177886)
2012
9
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. (23252872)
2012
10
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature. (22535612)
2012
11
Extraskeletal intracranial mesenchymal chondrosarcoma: report of a rare case. (22234225)
2011
12
Intramuscular, extraskeletal mesenchymal chondrosarcoma. (23548257)
2011
13
Mesenchymal chondrosarcoma of the cervical spine: A case report. (23393533)
2011
14
Sacral mesenchymal chondrosarcoma in childhood: a case report and review of the literature. (20677924)
2010
15
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. (20138330)
2010
16
Primary orbital mesenchymal chondrosarcoma: a case report and literature review. (18188507)
2009
17
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. (20014564)
2009
18
Mesenchymal chondrosarcoma mimicking apical periodontitis. (18928860)
2008
19
Mesenchymal chondrosarcoma of the maxilla: case report and literature review. (17517320)
2007
20
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
21
Mesenchymal chondrosarcoma of the orbit. (16985424)
2006
22
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
23
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
24
Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. (15511276)
2004
25
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. (15203726)
2004
26
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. (12817616)
2003
27
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. (10626952)
2000
28
Mesenchymal chondrosarcoma of the jaws. Report of four cases. (9804199)
1998
29
Extraskeletal mesenchymal chondrosarcoma of the labium majus. (8774664)
1996
30
Mesenchymal chondrosarcoma of the maxilla. (7964146)
1994
31
Extraskeletal mesenchymal chondrosarcoma of the orbit. (8374880)
1993
32
A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region. (1487666)
1992
33
Mesenchymal chondrosarcoma of the maxilla. Report of a case. (2019783)
1991
34
Pathologic quiz case 2. Mesenchymal chondrosarcoma. (2306360)
1990
35
Mesenchymal chondrosarcoma of the maxilla: report of a case. (3049993)
1988
36
Case report 484: Mesenchymal chondrosarcoma of the left fifth rib. (3212495)
1988
37
Mesenchymal chondrosarcoma: a case report. (3467042)
1987
38
Mesenchymal chondrosarcoma: report of a case. (3095275)
1986
39
Mesenchymal chondrosarcoma of the kidney. (6498739)
1984
40
A rare cause of spinal cord compression in childhood from intraspinal mesenchymal chondrosarcoma. A report of two cases and review of the literature. (6462441)
1984
41
Preoperative Sterispon embolisation to facilitate wide excision of mesenchymal chondrosarcoma of the ribs. (6463923)
1984
42
Mesenchymal chondrosarcoma in the young. (6402853)
1983
43
Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. (6825046)
1983
44
Case report 134. Mesenchymal chondrosarcoma of the right side of the pelvis and thigh. (7466420)
1981
45
Case report. Extraskeletal mesenchymal chondrosarcoma. (750463)
1978
46
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. (753003)
1978
47
Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. (365318)
1978
48
Mesenchymal chondrosarcoma of the orbit. (4451652)
1974
49
Intracranial mesenchymal chondrosarcoma. (4699884)
1973
50
Mesenchymal chondrosarcoma. (5049459)
1972

Variations for Mesenchymal Chondrosarcoma

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Expression for genes affiliated with Mesenchymal Chondrosarcoma

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Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

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Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.6CDX1, COL2A1, ACTC1
2
Show member pathways
9.6ACTC1, VIM, DES
39.5COL2A1, SOX9, GFAP
49.1GFAP, SOX9, VIM, COL2A1
58.9CDX1, NCOA2, MYOG
6
Show member pathways
8.6DES, GFAP, SOX9, VIM, MUC1, COL2A1
7
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis58
8.5MYOD1, MYOG, NCOA2

Compounds for genes affiliated with Mesenchymal Chondrosarcoma

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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1orcein439.7DES, VIM, ACTC1, S100B
2biotin43 24 1211.6DES, VIM, MUC1, ACTC1
3eosin439.6GFAP, VIM, MUC1, S100B
4procollagen439.6DES, VIM, ACTC1, COL2A1
5ganglioside439.5VIM, GFAP, DES
6chondroitin sulfate43 2410.5VIM, SOX9, GFAP
7mucicarmine439.4DES, VIM, MUC1, ACTC1, S100B
8b 723439.4S100B, ACTC1, MUC1, VIM, DES
9matrigel439.4GFAP, VIM, MUC1, ACTC1
10ribonucleic acid439.3SOX9, MYOG, MUC1, ACTC1
11dbc-amp439.3GFAP, VIM, S100B
12methionine439.2S100B, VIM, GFAP, DES
13iron43 2410.2S100B, ACTC1, VIM, GFAP, DES
14ascorbic acid43 2410.2S100B, COL2A1, MYOG, SOX9
15s 100439.1S100B, ACTC1, MUC1, VIM, GFAP, DES
16reticulin439.1DES, GFAP, VIM, MUC1, ACTC1, S100B
17hematoxylin439.1DES, GFAP, VIM, MUC1, ACTC1, S100B
184-hydroxytamoxifen439.1VIM, S100B, NCOA2
19formaldehyde43 2410.1DES, GFAP, VIM, MUC1, ACTC1, S100B
20dihydrotestosterone43 28 24 1212.0NCOA2, MUC1, VIM, DES
21glycogen43 2410.0DES, GFAP, VIM, MUC1, ACTC1, S100B
22ethanol43 49 24 1212.0S100B, MUC1, GFAP, DES
23forskolin43 49 1210.9GFAP, VIM, MYOG, MUC1, S100B
24adenylate438.9DES, GFAP, VIM, MYOG, S100B
25chloramphenicol43 2 49 1211.8VIM, MYOD1, MUC1, COL2A1, S100B
2612-o-tetradecanoylphorbol 13-acetate438.7MUC1, MYOG, MYOD1, VIM, DES
27estradiol43 24 1210.7DES, GFAP, VIM, MUC1, NCOA2
28butyrate438.6GFAP, VIM, MYOD1, MYOG, MUC1
29glutamine438.6GFAP, SOX9, VIM, S100B, NCOA2
30bromodeoxyuridine438.5DES, GFAP, VIM, MYOD1, MYOG, S100B
31acetylcholine43 49 28 24 1212.4DES, GFAP, VIM, MYOD1, MYOG, S100B
32lysine438.3DES, VIM, MYOD1, COL2A1, NCOA2
33progesterone43 28 59 24 1212.2DES, GFAP, VIM, MUC1, ACTC1, S100B
34zinc43 249.0GFAP, SOX9, MYOD1, COL2A1, S100B, NCOA2
35paraffin437.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
36creatinine437.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
37dexamethasone43 49 28 1210.8GFAP, SOX9, VIM, MUC1, ACTC1, COL2A1
38steroid437.8DES, SOX9, MYOD1, MYOG, ACTC1, S100B
39cysteine437.8DES, GFAP, VIM, MYOD1, MYOG, MUC1
40calcium43 49 24 1210.8DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
41arginine437.7DES, GFAP, VIM, MYOD1, COL2A1, S100B
42oxygen43 248.7DES, GFAP, SOX9, MYOD1, MYOG, MUC1
43vegf437.7DES, GFAP, SOX9, VIM, MYOD1, MYOG
44cyclic amp43 248.6DES, GFAP, SOX9, VIM, MYOD1, MUC1
45serine437.5DES, GFAP, SOX9, VIM, MYOD1, MYOG
46glucose437.5DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
47tyrosine437.4DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
48estrogen437.1DES, GFAP, VIM, MYOD1, MYOG, MUC1
49testosterone43 59 24 129.9DES, GFAP, SOX9, VIM, MYOD1, MYOG
50retinoic acid43 247.3DES, GFAP, SOX9, VIM, MYOD1, MYOG

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

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Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.1SYNM, VIM, GFAP, DES
2nucleoplasmGO:00056548.0HEY1, MYOD1, MYOG, NCOA2, SMARCB1
3nucleusGO:00056346.5SMARCB1, NUP107, SOX9, HEY1, MYOD1, MYOG

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:000320310.2SOX9, HEY1
2notochord developmentGO:003090310.1COL2A1, SOX9
3limb bud formationGO:006017410.1SOX9, COL2A1
4Bergmann glial cell differentiationGO:006002010.0GFAP, VIM
5astrocyte developmentGO:001400210.0GFAP, VIM
6intermediate filament organizationGO:00451099.9VIM, GFAP
7tissue homeostasisGO:00018949.9SOX9, COL2A1
8muscle filament slidingGO:00300499.9ACTC1, VIM, DES
9cartilage condensationGO:00015029.8COL2A1, SOX9
10cellular response to glucocorticoid stimulusGO:00713859.8MYOD1, HEY1
11long-term synaptic potentiationGO:00602919.7S100B, GFAP
12negative regulation of neuron projection developmentGO:00109779.7VIM, GFAP
13muscle cell fate commitmentGO:00426939.6MYOG, MYOD1
14skeletal muscle fiber developmentGO:00487419.5MYOD1, MYOG
15cellular response to estradiol stimulusGO:00713929.4MYOG, MYOD1
16positive regulation of muscle cell differentiationGO:00511499.0MYOG, MYOD1
17positive regulation of transcription from RNA polymerase II promoterGO:00459447.8CDX1, SMARCB1, SOX9, HEY1, MYOD1, MYOG

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.4SYNM, VIM, GFAP, DES
2E-box bindingGO:00708889.3MYOG, MYOD1
3identical protein bindingGO:00428029.1DES, VIM, COL2A1, S100B
4chromatin DNA bindingGO:00314909.0MYOG, MYOD1
5nuclear hormone receptor bindingGO:00352579.0NCOA2, MYOD1
6protein bindingGO:00055156.1HEY1, SOX9, NUP107, SMARCB1, DES, VIM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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Sources for Mesenchymal Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet