MCID: MSN005
MIFTS: 53

Mesenchymal Chondrosarcoma malady

Cancer diseases category
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Summaries for Mesenchymal Chondrosarcoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and fibroma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Striated Muscle Contraction. The compounds orcein and biotin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are vision/eye and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mesenchymal chondrosarcoma 8 10
chondrosarcoma, mesenchymal 62
chondrosarcoma mesenchymal 45


External Ids:

Disease Ontology8 DOID:4545
NCIt40 C3737
SNOMED-CT58 56565002
MeSH35 D018211

Related Diseases for Mesenchymal Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.9S100B, MUC1, VIM, SOX9, DES
2fibroma30.2DES, VIM, ACTC1
3sarcoma30.1DES, SMARCB1, VIM, MYOD1, MYOG, MUC1
4hemangiopericytoma30.1DES, VIM, MUC1, ACTC1, S100B
5extraskeletal mesenchymal chondrosarcoma10.9
6meningitis10.5
7adult mesenchymal chondrosarcoma10.4
8pediatric mesenchymal chondrosarcoma10.3
9cervicitis10.3
10osteomalacia10.3
11osteosarcoma10.3
12infantile myofibromatosis10.1DES
13alveolar soft part sarcoma10.1MYOD1
14fasciitis10.1ACTC1
15chondroblastoma10.1
16small cell sarcoma10.1
17meninges hemangiopericytoma10.1
18fibrous dysplasia10.1
19chondroma10.1
20keratoacanthoma10.1
21myxoid chondrosarcoma10.1
22periodontitis10.1
23thyroiditis10.1
24aneurysmal bone cysts10.1
25oncogenic osteomalacia10.1
26aneurysm10.1
27chondromyxoid fibroma10.1
28hidradenoma10.1MUC1
29retroperitoneal leiomyosarcoma10.1SMARCB1
30subependymal giant cell astrocytoma10.1GFAP
31cystadenocarcinoma10.1MUC1
32giant cell glioblastoma10.1GFAP
33congenital mesoblastic nephroma10.1SMARCB1
34malignant mesenchymoma10.1MYOD1, MYOG
35mixed glioma10.1GFAP
36synovial sarcoma10.1SSX1
37desmoplastic small round cell tumor10.1MUC1, DES
38desmoid tumor10.1DES, ACTC1
39fibrous meningioma10.1S100B, MUC1
40histiocytosis10.1S100B
41adenosarcoma10.1ACTC1, DES
42alexander disease10.1DES, GFAP
43myopathy congenital10.1MYOG, DES
44alveolar rhabdomyosarcoma10.1DES, MYOD1, MYOG
45adenomatoid tumor10.1VIM
46pineocytoma10.1GFAP, S100B
47cutaneous fibrous histiocytoma10.1DES, ACTC1, S100B
48neurilemmoma10.1SMARCB1, GFAP
49ganglioglioma10.1S100B, GFAP
50myxopapillary ependymoma10.1S100B, GFAP

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Symptoms for Mesenchymal Chondrosarcoma

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Drugs & Therapeutics for Mesenchymal Chondrosarcoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

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Anatomical Context for Mesenchymal Chondrosarcoma

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33MalaCards
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MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

33
Bone, Lung, Kidney, Pancreas, Cerebellum, Heart, Spinal cord, Brain, Spleen, Thyroid, Breast, Skin

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5COL2A1, MUC1, VIM, SOX9, GFAP, SMARCB1
2MP:00053818.4SMARCB1, GFAP, SOX9, MUC1, COL2A1, CDX1
3MP:00053697.8DES, GFAP, SOX9, HEY1, VIM, MYOD1
4MP:00053857.6DES, SMARCB1, GFAP, SOX9, HEY1, VIM
5MP:00053807.5SMARCB1, SOX9, HEY1, VIM, MYOG, COL2A1
6MP:00028737.3CDX1, GFAP, SOX9, HEY1, MYOD1, MYOG
7MP:00053767.2DES, SMARCB1, GFAP, SOX9, VIM, MYOD1
8MP:00053867.1DES, GFAP, SOX9, VIM, MYOG, COL2A1
9MP:00107687.0SOX9, GFAP, SMARCB1, DES, HEY1, VIM
10MP:00053786.4SMARCB1, GFAP, SOX9, HEY1, VIM, MYOD1

Publications for Mesenchymal Chondrosarcoma

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52PubMed
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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
2
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. (24255641)
2013
3
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
4
Intraparenchymal mesenchymal chondrosarcoma in an unusual location. (22406804)
2012
5
Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. (21615516)
2012
6
Primary mesenchymal chondrosarcoma of the kidney with synchronous implant and infiltrating urothelial carcinoma of the ureter. (22999069)
2012
7
Mesenchymal chondrosarcoma of the orbit: CT and MRI findings. (22177886)
2012
8
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. (23252872)
2012
9
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature. (22535612)
2012
10
Extraskeletal intracranial mesenchymal chondrosarcoma: report of a rare case. (22234225)
2011
11
Intramuscular, extraskeletal mesenchymal chondrosarcoma. (23548257)
2011
12
Mesenchymal chondrosarcoma of the cervical spine: A case report. (23393533)
2011
13
Sacral mesenchymal chondrosarcoma in childhood: a case report and review of the literature. (20677924)
2010
14
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. (20138330)
2010
15
Primary orbital mesenchymal chondrosarcoma: a case report and literature review. (18188507)
2009
16
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. (20014564)
2009
17
Mesenchymal chondrosarcoma of the maxilla: case report and literature review. (17517320)
2007
18
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
19
Mesenchymal chondrosarcoma of the orbit. (16985424)
2006
20
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
21
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
22
Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. (15511276)
2004
23
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. (15203726)
2004
24
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. (12817616)
2003
25
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. (10626952)
2000
26
Mesenchymal chondrosarcoma of the maxilla: report of a case. (10368101)
1999
27
Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. (9635527)
1998
28
Mesenchymal chondrosarcoma of the jaws. Report of four cases. (9804199)
1998
29
Extraskeletal mesenchymal chondrosarcoma of the labium majus. (8774664)
1996
30
Mesenchymal chondrosarcoma of the maxilla. (7964146)
1994
31
Extraskeletal mesenchymal chondrosarcoma of the orbit. (8374880)
1993
32
A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region. (1487666)
1992
33
Mesenchymal chondrosarcoma of the maxilla. Report of a case. (2019783)
1991
34
Pathologic quiz case 2. Mesenchymal chondrosarcoma. (2306360)
1990
35
Mesenchymal chondrosarcoma of the maxilla: report of a case. (3049993)
1988
36
Case report 484: Mesenchymal chondrosarcoma of the left fifth rib. (3212495)
1988
37
Mesenchymal chondrosarcoma: a case report. (3467042)
1987
38
Mesenchymal chondrosarcoma: report of a case. (3095275)
1986
39
Mesenchymal chondrosarcoma of the kidney. (6498739)
1984
40
A rare cause of spinal cord compression in childhood from intraspinal mesenchymal chondrosarcoma. A report of two cases and review of the literature. (6462441)
1984
41
Preoperative Sterispon embolisation to facilitate wide excision of mesenchymal chondrosarcoma of the ribs. (6463923)
1984
42
Mesenchymal chondrosarcoma in the young. (6402853)
1983
43
Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. (6825046)
1983
44
Case report 134. Mesenchymal chondrosarcoma of the right side of the pelvis and thigh. (7466420)
1981
45
Case report. Extraskeletal mesenchymal chondrosarcoma. (750463)
1978
46
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. (753003)
1978
47
Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. (365318)
1978
48
Mesenchymal chondrosarcoma of the orbit. (4451652)
1974
49
Intracranial mesenchymal chondrosarcoma. (4699884)
1973
50
Mesenchymal chondrosarcoma. (5049459)
1972

Variations for Mesenchymal Chondrosarcoma

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Expression for genes affiliated with Mesenchymal Chondrosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 12EMD Millipore, 53QIAGEN
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Pathways related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.6COL2A1, CDX1, ACTC1
2
Show member pathways
9.6VIM, DES, ACTC1
39.5COL2A1, SOX9, GFAP
4
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2VIM, SYNM, DES, GFAP
59.1GFAP, SOX9, COL2A1, VIM
68.9MYOG, CDX1, NCOA2
7
Show member pathways
8.6DES, GFAP, SOX9, VIM, MUC1, COL2A1
8
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
8.5NCOA2, MYOD1, MYOG

Compounds for genes affiliated with Mesenchymal Chondrosarcoma

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1orcein459.7VIM, ACTC1, S100B, DES
2biotin45 24 1111.6MUC1, ACTC1, VIM, DES
3eosin459.6S100B, GFAP, MUC1, VIM
4procollagen459.6ACTC1, COL2A1, VIM, DES
5ganglioside459.5DES, GFAP, VIM
6chondroitin sulfate45 2410.5VIM, GFAP, SOX9
7mucicarmine459.4DES, VIM, MUC1, ACTC1, S100B
8b 723459.4ACTC1, DES, VIM, MUC1, S100B
9matrigel459.4ACTC1, GFAP, VIM, MUC1
10ribonucleic acid459.3ACTC1, MUC1, MYOG, SOX9
11dbc-amp459.3S100B, VIM, GFAP
12methionine459.2S100B, GFAP, DES, VIM
13iron45 2410.2VIM, DES, GFAP, S100B, ACTC1
14ascorbic acid45 2410.2S100B, COL2A1, SOX9, MYOG
15s 100459.1VIM, S100B, ACTC1, MUC1, DES, GFAP
16reticulin459.1VIM, MUC1, ACTC1, S100B, GFAP, DES
17hematoxylin459.1MUC1, S100B, GFAP, ACTC1, VIM, DES
184-hydroxytamoxifen459.1NCOA2, S100B, VIM
19formaldehyde45 2410.1VIM, ACTC1, S100B, GFAP, MUC1, DES
20dihydrotestosterone45 29 24 1112.0NCOA2, DES, VIM, MUC1
21glycogen45 2410.0S100B, ACTC1, MUC1, VIM, GFAP, DES
22ethanol45 51 24 1112.0MUC1, S100B, GFAP, DES
23forskolin45 51 1110.9MYOG, VIM, GFAP, S100B, MUC1
24adenylate458.9VIM, GFAP, DES, MYOG, S100B
25chloramphenicol45 3 51 1111.8COL2A1, VIM, MYOD1, MUC1, S100B
2612-o-tetradecanoylphorbol 13-acetate458.7DES, VIM, MYOG, MUC1, MYOD1
27estradiol45 24 1110.7GFAP, DES, VIM, MUC1, NCOA2
28butyrate458.6GFAP, MUC1, MYOG, VIM, MYOD1
29glutamine458.6SOX9, VIM, S100B, GFAP, NCOA2
30bromodeoxyuridine458.5MYOD1, VIM, DES, MYOG, S100B, GFAP
31acetylcholine45 51 29 24 1112.4DES, GFAP, MYOD1, MYOG, S100B, VIM
32lysine458.3NCOA2, COL2A1, MYOD1, DES, VIM
33progesterone45 29 61 24 1112.2ACTC1, NCOA2, DES, GFAP, VIM, S100B
34zinc45 249.0MYOD1, GFAP, S100B, SOX9, NCOA2, COL2A1
35paraffin457.9GFAP, VIM, MYOD1, MYOG, MUC1, S100B
36creatinine457.9ACTC1, S100B, MYOG, MYOD1, GFAP, DES
37dexamethasone45 51 29 1110.8COL2A1, SOX9, GFAP, ACTC1, S100B, MUC1
38steroid457.8MYOD1, NCOA2, S100B, ACTC1, MYOG, DES
39cysteine457.8MUC1, MYOD1, S100B, COL2A1, DES, GFAP
40calcium45 51 24 1110.8DES, ACTC1, GFAP, MYOD1, MUC1, COL2A1
41arginine457.7COL2A1, S100B, NCOA2, VIM, DES, GFAP
42oxygen45 248.7S100B, COL2A1, ACTC1, MUC1, MYOG, MYOD1
43vegf457.7MYOG, MYOD1, MUC1, ACTC1, S100B, VIM
44cyclic amp45 248.6MUC1, VIM, SOX9, GFAP, DES, S100B
45serine457.5MUC1, DES, GFAP, SOX9, VIM, MYOD1
46glucose457.5NCOA2, S100B, ACTC1, MYOG, MYOD1, GFAP
47tyrosine457.4ACTC1, S100B, NCOA2, MUC1, MYOG, MYOD1
48estrogen457.1ACTC1, MYOG, S100B, MUC1, NCOA2, VIM
49testosterone45 61 24 119.9DES, NCOA2, S100B, ACTC1, MUC1, MYOG
50retinoic acid45 247.3MUC1, ACTC1, COL2A1, S100B, NCOA2, CDX1

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

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16Gene Ontology
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Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1SYNM, VIM, GFAP, DES
2nucleoplasmGO:0056548.0HEY1, MYOD1, MYOG, NCOA2, SMARCB1
3nucleusGO:0056346.5SMARCB1, NUP107, SOX9, HEY1, MYOD1, MYOG

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.2SOX9, HEY1
2notochord developmentGO:03090310.1COL2A1, SOX9
3limb bud formationGO:06017410.1SOX9, COL2A1
4Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
5astrocyte developmentGO:01400210.0GFAP, VIM
6intermediate filament organizationGO:0451099.9VIM, GFAP
7tissue homeostasisGO:0018949.9SOX9, COL2A1
8muscle filament slidingGO:0300499.9ACTC1, VIM, DES
9cartilage condensationGO:0015029.8COL2A1, SOX9
10cellular response to glucocorticoid stimulusGO:0713859.8MYOD1, HEY1
11long-term synaptic potentiationGO:0602919.7S100B, GFAP
12negative regulation of neuron projection developmentGO:0109779.7VIM, GFAP
13muscle cell fate commitmentGO:0426939.6MYOG, MYOD1
14skeletal muscle fiber developmentGO:0487419.5MYOD1, MYOG
15cellular response to estradiol stimulusGO:0713929.4MYOG, MYOD1
16positive regulation of muscle cell differentiationGO:0511499.0MYOG, MYOD1
17positive regulation of transcription from RNA polymerase II promoterGO:0459447.8CDX1, SMARCB1, SOX9, HEY1, MYOD1, MYOG

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.4SYNM, VIM, GFAP, DES
2E-box bindingGO:0708889.3MYOG, MYOD1
3identical protein bindingGO:0428029.1DES, VIM, COL2A1, S100B
4chromatin DNA bindingGO:0314909.0MYOG, MYOD1
5nuclear hormone receptor bindingGO:0352579.0NCOA2, MYOD1
6protein bindingGO:0055156.1HEY1, SOX9, NUP107, SMARCB1, DES, VIM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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Sources for Mesenchymal Chondrosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet