MCID: MSN005
MIFTS: 38

Mesenchymal Chondrosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

Aliases & Descriptions for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 14
Chondrosarcoma, Mesenchymal 42 69
Chondrosarcoma Mesenchymal 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 42 D018211
NCIt 47 C3737
SNOMED-CT 64 56565002
UMLS 69 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondroblastoma and adult mesenchymal chondrosarcoma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cellular and embryo

Wikipedia : 71 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 chondroblastoma 29.6 MUC1 VIM
2 adult mesenchymal chondrosarcoma 12.3
3 extraskeletal mesenchymal chondrosarcoma 12.2
4 pediatric mesenchymal chondrosarcoma 12.0
5 chondrosarcoma 10.9
6 vagina leiomyosarcoma 10.2 DES MUC1
7 invasive malignant thymoma 10.2 DES MUC1
8 ovarian cystadenoma 10.2 DES MUC1
9 episodic ataxia 10.2 DES MUC1
10 polydactyly cleft lip palate psychomotor retardation 10.2 DES MUC1
11 pseudohermaphrodism anorectal anomalies 10.2 DES MUC1
12 inflammatory linear verrucous epidermal nevus 10.2 DES VIM
13 lymphomatous thyroiditis 10.2 DES VIM
14 osteomyelitis 10.2 DES VIM
15 congenital myasthenic syndrome 10.2 DES VIM
16 malignant dermis tumor 10.2 DES VIM
17 urethral cancer 10.2 DES VIM
18 adult endodermal sinus tumor 10.2 DES VIM
19 biemond syndrome 10.1 DES VIM
20 liver angiosarcoma 10.1 DES VIM
21 intestinal obstruction 10.1 DES VIM
22 cavernous sinus meningioma 10.1 DES VIM
23 male reproductive system disease 10.1 DES VIM
24 male urethral cancer 10.1 DES VIM
25 dyslexia 10.1 DES VIM
26 immunodeficiency due to a classical component pathway complement deficiency 10.1 MUC1 VIM
27 glomangioma 10.1 DES VIM
28 autosomal recessive stickler syndrome 10.1 MUC1 VIM
29 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.1 MUC1 VIM
30 microinvasive cervical squamous cell carcinoma 10.1 MUC1 VIM
31 endometrial stromal sarcoma 10.1 MUC1 VIM
32 subglottis verrucous carcinoma 10.1 MUC1 VIM
33 bladder adenocarcinoma 10.1 MUC1 VIM
34 conjunctival cancer 10.1 MUC1 VIM
35 skin glomus tumor 10.1 DES VIM
36 clear cell ependymoma 10.1 MUC1 VIM
37 behcet's syndrome arthropathy 10.1 MUC1 VIM
38 sternum cancer 10.1 MUC1 VIM
39 avian influenza 10.1 MUC1 VIM
40 t-cell childhood lymphoblastic lymphoma 10.1 DES VIM
41 aneurysm of sinus of valsalva 10.1 MUC1 VIM
42 pilar sheath acanthoma 10.1 DES VIM
43 testicular granulosa cell tumor 10.1 MUC1 VIM
44 vulvar angiokeratoma 10.1 MUC1 VIM
45 lymphangiosarcoma 10.1 MUC1 VIM
46 enchondromatosis dwarfism deafness 10.1 DES VIM
47 progeria 10.1 MUC1 VIM
48 cauda equina intradural extramedullary astrocytoma 10.1 MUC1 VIM
49 fitz-hugh-curtis syndrome 10.1 DES VIM
50 gestational trophoblastic neoplasm 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX1 DES HEY1 NCOA2 SOX9 VIM
2 embryo MP:0005380 9.1 CDX1 HEY1 IRF2BP2 NCOA2 SOX9 VIM

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7 pancreatic polypeptide Phase 3
8 Analgesics Phase 3
9 Alkylating Agents Phase 2, Phase 3
10 Adjuvants, Anesthesia Phase 3
11 Narcotics Phase 3
12 Topoisomerase Inhibitors Phase 2, Phase 3
13 Analgesics, Opioid Phase 3
14 Anesthetics Phase 3
15 Anesthetics, General Phase 3
16 Anesthetics, Intravenous Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Anti-Bacterial Agents Phase 2, Phase 3
19 Isophosphamide mustard Phase 2, Phase 3
20 Liver Extracts Phase 3
21 Antibiotics, Antitubercular Phase 2, Phase 3
22 Antineoplastic Agents, Alkylating Phase 2, Phase 3
23 Central Nervous System Depressants Phase 3
24 Cola Nutraceutical Phase 3
25
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
26
Etoposide Approved Phase 2 33419-42-0 36462
27
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
28
Lenograstim Approved Phase 2 135968-09-1
29
Dactinomycin Approved Phase 2 50-76-0 2019 457193
30
Epirubicin Approved Phase 2 56420-45-2 41867
31
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
32
Everolimus Approved Phase 2 159351-69-6 6442177
33
Pembrolizumab Approved Phase 2 1374853-91-4
34
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
35 Nucleic Acid Synthesis Inhibitors Phase 2
36 Etoposide phosphate Phase 2
37 Anti-Infective Agents Phase 2
38 Immunosuppressive Agents Phase 2
39 Antimitotic Agents Phase 2
40 Antirheumatic Agents Phase 2
41 Antineoplastic Agents, Phytogenic Phase 2
42 Immunoglobulins Phase 2
43 Antifungal Agents Phase 2
44 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
3 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
4 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2
5 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2
6 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

39
Bone, Kidney, Lung, Pancreas, Heart, Thyroid, Cerebellum

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 300)
id Title Authors Year
1
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
2
CORR Insights(Ar): Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2016
3
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
4
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
5
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. ( 27617402 )
2016
6
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
7
Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 26975384 )
2016
8
Mesenchymal chondrosarcoma of mandible. ( 27721626 )
2016
9
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma. ( 28042016 )
2016
10
Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. ( 27544802 )
2016
11
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
12
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. ( 27487949 )
2016
13
Intraoperative high-field magnetic resonance imaging combined with neuronavigation-guided resection of intracranial mesenchymal chondrosarcoma in Broca's area: a rare case report and literature review. ( 26064406 )
2015
14
Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma. ( 26556438 )
2015
15
Intraparenchymal mesenchymal chondrosarcoma of the frontal lobe - a case report and molecular detection of specific gene fusions from archival FFPE sample. ( 25907264 )
2015
16
Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. ( 25849226 )
2015
17
Primary renal mesenchymal chondrosarcoma: a case report. ( 25733289 )
2015
18
Maxillary mesenchymal chondrosarcoma presenting with epistaxis in a child. ( 26629302 )
2015
19
A Case of Mesenchymal Chondrosarcoma Arising from the Femoral Vein with 8A Years of Follow-up. ( 26133997 )
2015
20
Primary mesenchymal chondrosarcoma with bilateral kidney invasion and calcification in renal pelvis: A case report and review of the literature. ( 26622628 )
2015
21
Imaging features of extraskeletal mesenchymal chondrosarcoma of the hand. ( 25797212 )
2015
22
A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. ( 25838713 )
2015
23
Mesenchymal chondrosarcoma: prognostic factors and outcome in 113 patients. A European Musculoskeletal Oncology Society study. ( 25529371 )
2015
24
Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review. ( 26146478 )
2015
25
An extraordinary case of mesenchymal chondrosarcoma metastasis in the thyroid. ( 25510635 )
2015
26
Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. ( 24839999 )
2014
27
A rare tentorial mesenchymal chondrosarcoma in posterior cranial fossa: case report. ( 25168329 )
2014
28
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. ( 24932271 )
2014
29
Mesenchymal chondrosarcoma of posterior maxilla: report of a case with brief literature review. ( 25031908 )
2014
30
Dumbbell mesenchymal chondrosarcoma: report of a rare case. ( 22828915 )
2014
31
Mesenchymal chondrosarcoma of the mandible: a rare malignant tumor. ( 25255353 )
2014
32
Chemotherapy improved prognosis of mesenchymal chondrosarcoma with rare metastasis to the pancreas. ( 24716041 )
2014
33
Extraskeletal intraspinal mesenchymal chondrosarcoma; 18F-FDG PET/CT finding. ( 23877507 )
2014
34
Mesenchymal chondrosarcoma of the uterus. ( 24471970 )
2014
35
Intravascular mesenchymal chondrosarcoma. ( 25457141 )
2014
36
Congenital sacral mesenchymal chondrosarcoma in a neonate: a case report and review of literature. ( 24647306 )
2014
37
Mesenchymal chondrosarcoma of mandible: A rare case report and review. ( 25364172 )
2014
38
Mesenchymal chondrosarcoma of kidney. ( 24744526 )
2014
39
Primary spinal intradural mesenchymal chondrosarcoma with detection of fusion gene HEY1-NCOA2: A paediatric case report and review of the literature. ( 25202377 )
2014
40
Mesenchymal chondrosarcoma of the right buccal region: A case report and review of the literature. ( 25364427 )
2014
41
Costal mesenchymal chondrosarcoma with diffuse pleural and pericardial explantation in a pygmy goat. ( 24791071 )
2014
42
Mesenchymal chondrosarcoma diagnosed on FISH for HEY1-NCOA2 fusion gene. ( 25336010 )
2014
43
Management of renal extraskeletal mesenchymal chondrosarcoma. ( 25511186 )
2014
44
Mesenchymal chondrosarcoma: a case report. ( 23966829 )
2013
45
Primary extraskeletal mesenchymal chondrosarcoma of the vulva. ( 24328027 )
2013
46
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. ( 24082926 )
2013
47
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. ( 24124145 )
2013
48
Extensive anterior skull-base mesenchymal chondrosarcoma: unusual cause of multiple indolent masses on the forehead. ( 23557906 )
2013
49
Radiation Therapy Is Associated With Fewer Recurrences in Mesenchymal Chondrosarcoma. ( 23709273 )
2013
50
Giant primary mesenchymal chondrosarcoma of the lung: case report and review of literature. ( 23196662 )
2013

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.81 DES MUC1 VIM
2 10.93 CDX1 SOX9 VIM
3
Show member pathways
10.61 DES VIM

GO Terms for Mesenchymal Chondrosarcoma

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.56 CDX1 HEY1 NCOA2 SOX9
2 muscle filament sliding GO:0030049 9.16 DES VIM
3 intermediate filament organization GO:0045109 8.96 DES VIM
4 endocardial cushion morphogenesis GO:0003203 8.62 HEY1 SOX9

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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