MCID: MSN005
MIFTS: 54

Mesenchymal Chondrosarcoma malady

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Summaries for Mesenchymal Chondrosarcoma

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Wikipedia:65 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards based summary: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and fibroma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Striated Muscle Contraction. The compounds orcein and biotin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are vision/eye and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Mesenchymal Chondrosarcoma, Aliases & Descriptions:

Name: Mesenchymal Chondrosarcoma 8 10
Chondrosarcoma, Mesenchymal 62
 
Chondrosarcoma Mesenchymal 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4545
NCIt39 C3737
SNOMED-CT57 56565002
MeSH34 D018211

Related Diseases for Mesenchymal Chondrosarcoma

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Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.7S100B, MUC1, VIM, SOX9, DES
2fibroma30.3DES, VIM, ACTC1
3hemangiopericytoma29.8DES, VIM, MUC1, ACTC1, S100B
4sarcoma29.3DES, SMARCB1, VIM, MYOD1, MYOG, MUC1
5extraskeletal mesenchymal chondrosarcoma10.9
6infantile myofibromatosis10.6DES
7alveolar soft part sarcoma10.5MYOD1
8meningitis10.5
9fasciitis10.5ACTC1
10hidradenoma10.5MUC1
11retroperitoneal leiomyosarcoma10.4SMARCB1
12subependymal giant cell astrocytoma10.4GFAP
13cystadenocarcinoma10.4MUC1
14giant cell glioblastoma10.4GFAP
15congenital mesoblastic nephroma10.4SMARCB1
16adult mesenchymal chondrosarcoma10.4
17myoma10.4DES, MYOG
18malignant mesenchymoma10.4MYOD1, MYOG
19mixed glioma10.4GFAP
20synovial sarcoma10.4SSX1
21desmoplastic small round cell tumor10.4MUC1, DES
22desmoid tumor10.4DES, ACTC1
23fibrous meningioma10.4S100B, MUC1
24pediatric mesenchymal chondrosarcoma10.4
25cervicitis10.4
26histiocytosis10.4S100B
27adenosarcoma10.4ACTC1, DES
28alexander disease10.3DES, GFAP
29myopathy congenital10.3MYOG, DES
30alveolar rhabdomyosarcoma10.3DES, MYOD1, MYOG
31adenomatoid tumor10.3VIM
32pineocytoma10.3GFAP, S100B
33osteomalacia10.3
34osteosarcoma10.3
35cutaneous fibrous histiocytoma10.3DES, ACTC1, S100B
36neurilemmoma10.3SMARCB1, GFAP
37ganglioglioma10.3S100B, GFAP
38myxopapillary ependymoma10.3S100B, GFAP
39papillary ependymoma10.2S100B, GFAP
40choroid plexus carcinoma10.2S100B, GFAP
41gemistocytic astrocytoma10.2GFAP, S100B
42neuroendocrine carcinoma10.2S100B, SYNM, MUC1
43tubular adenocarcinoma10.2ACTC1, MUC1
44embryonal rhabdomyosarcoma10.2ACTC1, MYOG, MYOD1, DES
45myopathy10.2DES, MYOD1, MYOG, SYNM
46campomelic dysplasia10.2COL2A1, SOX9
47syringoma10.2S100B, MUC1, GFAP
48achondroplasia10.2COL2A1, SOX9
49mucoepidermoid carcinoma10.1MUC1, ACTC1
50clear cell ependymoma10.1MUC1, VIM

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Symptoms for Mesenchymal Chondrosarcoma

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Drugs & Therapeutics for Mesenchymal Chondrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

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Anatomical Context for Mesenchymal Chondrosarcoma

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MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

32
Bone, Kidney, Lung, Pancreas, Cerebellum, Heart, Spleen, Brain, Spinal cord, Thyroid, Breast, Skin, Uterus

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5COL2A1, MUC1, VIM, SOX9, GFAP, SMARCB1
2MP:00053818.4SMARCB1, GFAP, SOX9, MUC1, COL2A1, CDX1
3MP:00053697.8DES, GFAP, SOX9, HEY1, VIM, MYOD1
4MP:00053857.6DES, SMARCB1, GFAP, SOX9, HEY1, VIM
5MP:00053807.5SMARCB1, SOX9, HEY1, VIM, MYOG, COL2A1
6MP:00028737.3CDX1, GFAP, SOX9, HEY1, MYOD1, MYOG
7MP:00053767.2DES, SMARCB1, GFAP, SOX9, VIM, MYOD1
8MP:00053867.1DES, GFAP, SOX9, VIM, MYOG, COL2A1
9MP:00107687.0SOX9, GFAP, SMARCB1, DES, HEY1, VIM
10MP:00053786.4SMARCB1, GFAP, SOX9, HEY1, VIM, MYOD1

Publications for Mesenchymal Chondrosarcoma

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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
2
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. (24255641)
2013
3
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
4
Intraparenchymal mesenchymal chondrosarcoma in an unusual location. (22406804)
2012
5
Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. (21615516)
2012
6
Primary mesenchymal chondrosarcoma of the kidney with synchronous implant and infiltrating urothelial carcinoma of the ureter. (22999069)
2012
7
Mesenchymal chondrosarcoma of the orbit: CT and MRI findings. (22177886)
2012
8
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. (23252872)
2012
9
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature. (22535612)
2012
10
Extraskeletal intracranial mesenchymal chondrosarcoma: report of a rare case. (22234225)
2011
11
Intramuscular, extraskeletal mesenchymal chondrosarcoma. (23548257)
2011
12
Mesenchymal chondrosarcoma of the cervical spine: A case report. (23393533)
2011
13
Sacral mesenchymal chondrosarcoma in childhood: a case report and review of the literature. (20677924)
2010
14
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. (20138330)
2010
15
Primary orbital mesenchymal chondrosarcoma: a case report and literature review. (18188507)
2009
16
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. (20014564)
2009
17
Mesenchymal chondrosarcoma of the maxilla: case report and literature review. (17517320)
2007
18
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
19
Mesenchymal chondrosarcoma of the orbit. (16985424)
2006
20
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
21
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
22
Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. (15511276)
2004
23
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. (15203726)
2004
24
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. (12817616)
2003
25
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. (10626952)
2000
26
Mesenchymal chondrosarcoma of the maxilla: report of a case. (10368101)
1999
27
Mesenchymal chondrosarcoma of the jaw bones: clinicopathologic study of 19 cases. (9635527)
1998
28
Mesenchymal chondrosarcoma of the jaws. Report of four cases. (9804199)
1998
29
Extraskeletal mesenchymal chondrosarcoma of the labium majus. (8774664)
1996
30
Mesenchymal chondrosarcoma of the maxilla. (7964146)
1994
31
Extraskeletal mesenchymal chondrosarcoma of the orbit. (8374880)
1993
32
A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region. (1487666)
1992
33
Mesenchymal chondrosarcoma of the maxilla. Report of a case. (2019783)
1991
34
Pathologic quiz case 2. Mesenchymal chondrosarcoma. (2306360)
1990
35
Mesenchymal chondrosarcoma of the maxilla: report of a case. (3049993)
1988
36
Case report 484: Mesenchymal chondrosarcoma of the left fifth rib. (3212495)
1988
37
Mesenchymal chondrosarcoma: a case report. (3467042)
1987
38
Mesenchymal chondrosarcoma: report of a case. (3095275)
1986
39
Mesenchymal chondrosarcoma of the kidney. (6498739)
1984
40
A rare cause of spinal cord compression in childhood from intraspinal mesenchymal chondrosarcoma. A report of two cases and review of the literature. (6462441)
1984
41
Preoperative Sterispon embolisation to facilitate wide excision of mesenchymal chondrosarcoma of the ribs. (6463923)
1984
42
Mesenchymal chondrosarcoma in the young. (6402853)
1983
43
Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. (6825046)
1983
44
Case report 134. Mesenchymal chondrosarcoma of the right side of the pelvis and thigh. (7466420)
1981
45
Case report. Extraskeletal mesenchymal chondrosarcoma. (750463)
1978
46
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. (753003)
1978
47
Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. (365318)
1978
48
Mesenchymal chondrosarcoma of the orbit. (4451652)
1974
49
Intracranial mesenchymal chondrosarcoma. (4699884)
1973
50
Mesenchymal chondrosarcoma. (5049459)
1972

Variations for Mesenchymal Chondrosarcoma

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Expression for genes affiliated with Mesenchymal Chondrosarcoma

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Expression patterns in normal tissues for genes affiliated with Mesenchymal Chondrosarcoma

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Pathways for genes affiliated with Mesenchymal Chondrosarcoma

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Pathways related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.6CDX1, COL2A1, ACTC1
2
Show member pathways
9.6ACTC1, VIM, DES
39.5COL2A1, SOX9, GFAP
4
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2SYNM, VIM, GFAP, DES
59.1GFAP, SOX9, VIM, COL2A1
68.9CDX1, NCOA2, MYOG
7
Show member pathways
8.6DES, GFAP, SOX9, VIM, MUC1, COL2A1
8
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
8.5MYOD1, MYOG, NCOA2

Compounds for genes affiliated with Mesenchymal Chondrosarcoma

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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1orcein449.7DES, VIM, ACTC1, S100B
2biotin44 24 1111.6DES, VIM, MUC1, ACTC1
3eosin449.6GFAP, VIM, MUC1, S100B
4procollagen449.6DES, VIM, ACTC1, COL2A1
5ganglioside449.5VIM, GFAP, DES
6chondroitin sulfate44 2410.5VIM, SOX9, GFAP
7mucicarmine449.4DES, VIM, MUC1, ACTC1, S100B
8b 723449.4S100B, ACTC1, MUC1, VIM, DES
9matrigel449.4GFAP, VIM, MUC1, ACTC1
10ribonucleic acid449.3SOX9, MYOG, MUC1, ACTC1
11dbc-amp449.3GFAP, VIM, S100B
12methionine449.2S100B, VIM, GFAP, DES
13iron44 2410.2S100B, ACTC1, VIM, GFAP, DES
14ascorbic acid44 2410.2S100B, COL2A1, MYOG, SOX9
15s 100449.1S100B, ACTC1, MUC1, VIM, GFAP, DES
16reticulin449.1DES, GFAP, VIM, MUC1, ACTC1, S100B
17hematoxylin449.1DES, GFAP, VIM, MUC1, ACTC1, S100B
184-hydroxytamoxifen449.1VIM, S100B, NCOA2
19formaldehyde44 2410.1DES, GFAP, VIM, MUC1, ACTC1, S100B
20dihydrotestosterone44 28 24 1112.0NCOA2, MUC1, VIM, DES
21glycogen44 2410.0DES, GFAP, VIM, MUC1, ACTC1, S100B
22ethanol44 50 24 1112.0S100B, MUC1, GFAP, DES
23forskolin44 50 1110.9GFAP, VIM, MYOG, MUC1, S100B
24adenylate448.9DES, GFAP, VIM, MYOG, S100B
25chloramphenicol44 2 50 1111.8VIM, MYOD1, MUC1, COL2A1, S100B
2612-o-tetradecanoylphorbol 13-acetate448.7MUC1, MYOG, MYOD1, VIM, DES
27estradiol44 24 1110.7DES, GFAP, VIM, MUC1, NCOA2
28butyrate448.6GFAP, VIM, MYOD1, MYOG, MUC1
29glutamine448.6GFAP, SOX9, VIM, S100B, NCOA2
30bromodeoxyuridine448.5DES, GFAP, VIM, MYOD1, MYOG, S100B
31acetylcholine44 50 28 24 1112.4DES, GFAP, VIM, MYOD1, MYOG, S100B
32lysine448.3DES, VIM, MYOD1, COL2A1, NCOA2
33progesterone44 28 61 24 1112.2DES, GFAP, VIM, MUC1, ACTC1, S100B
34zinc44 249.0GFAP, SOX9, MYOD1, COL2A1, S100B, NCOA2
35paraffin447.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
36creatinine447.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
37dexamethasone44 50 28 1110.8GFAP, SOX9, VIM, MUC1, ACTC1, COL2A1
38steroid447.8DES, SOX9, MYOD1, MYOG, ACTC1, S100B
39cysteine447.8DES, GFAP, VIM, MYOD1, MYOG, MUC1
40calcium44 50 24 1110.8DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
41arginine447.7DES, GFAP, VIM, MYOD1, COL2A1, S100B
42oxygen44 248.7DES, GFAP, SOX9, MYOD1, MYOG, MUC1
43vegf447.7DES, GFAP, SOX9, VIM, MYOD1, MYOG
44cyclic amp44 248.6DES, GFAP, SOX9, VIM, MYOD1, MUC1
45serine447.5DES, GFAP, SOX9, VIM, MYOD1, MYOG
46glucose447.5DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
47tyrosine447.4DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
48estrogen447.1DES, GFAP, VIM, MYOD1, MYOG, MUC1
49testosterone44 61 24 119.9DES, GFAP, SOX9, VIM, MYOD1, MYOG
50retinoic acid44 247.3DES, GFAP, SOX9, VIM, MYOD1, MYOG

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

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Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1SYNM, VIM, GFAP, DES
2nucleoplasmGO:0056548.0HEY1, MYOD1, MYOG, NCOA2, SMARCB1
3nucleusGO:0056346.5SMARCB1, NUP107, SOX9, HEY1, MYOD1, MYOG

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.2SOX9, HEY1
2notochord developmentGO:03090310.1COL2A1, SOX9
3limb bud formationGO:06017410.1SOX9, COL2A1
4Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
5astrocyte developmentGO:01400210.0GFAP, VIM
6intermediate filament organizationGO:0451099.9VIM, GFAP
7tissue homeostasisGO:0018949.9SOX9, COL2A1
8muscle filament slidingGO:0300499.9ACTC1, VIM, DES
9cartilage condensationGO:0015029.8COL2A1, SOX9
10cellular response to glucocorticoid stimulusGO:0713859.8MYOD1, HEY1
11long-term synaptic potentiationGO:0602919.7S100B, GFAP
12negative regulation of neuron projection developmentGO:0109779.7VIM, GFAP
13muscle cell fate commitmentGO:0426939.6MYOG, MYOD1
14skeletal muscle fiber developmentGO:0487419.5MYOD1, MYOG
15cellular response to estradiol stimulusGO:0713929.4MYOG, MYOD1
16positive regulation of muscle cell differentiationGO:0511499.0MYOG, MYOD1
17positive regulation of transcription from RNA polymerase II promoterGO:0459447.8CDX1, SMARCB1, SOX9, HEY1, MYOD1, MYOG

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.4SYNM, VIM, GFAP, DES
2E-box bindingGO:0708889.3MYOG, MYOD1
3identical protein bindingGO:0428029.1DES, VIM, COL2A1, S100B
4chromatin DNA bindingGO:0314909.0MYOG, MYOD1
5nuclear hormone receptor bindingGO:0352579.0NCOA2, MYOD1
6protein bindingGO:0055156.1HEY1, SOX9, NUP107, SMARCB1, DES, VIM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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Sources for Mesenchymal Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet