MCID: MSN005
MIFTS: 50

Mesenchymal Chondrosarcoma malady

Summaries for Mesenchymal Chondrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and osteosarcoma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Striated Muscle Contraction and Neural Crest Differentiation. The compounds orcein and creatinine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

mesenchymal chondrosarcoma 8 10
chondrosarcoma, mesenchymal 60
chondrosarcoma mesenchymal 44


External Ids:

Disease Ontology8 DOID:4545
MeSH34 D018211
SNOMED-CT56 56565002
NCIt39 C3737

Related Diseases for Mesenchymal Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.9MUC1, DES, SOX9, S100B, VIM
2osteosarcoma30.3MYOD1, SOX9
3sarcoma30.3VIM, S100B, SMARCB1, ACTC1, MUC1, MYOG
4hemangiopericytoma30.1VIM, S100B, DES, MUC1, ACTC1
5extraskeletal mesenchymal chondrosarcoma10.9
6intracranial chondrosarcoma10.7
7pediatric mesenchymal chondrosarcoma10.5
8adult mesenchymal chondrosarcoma10.5
9meningitis10.5
10cervicitis10.3
11osteomalacia10.2
12small cell sarcoma10.2
13chondroblastoma10.1
14fibrous dysplasia10.1
15meninges hemangiopericytoma10.1
16bone osteosarcoma10.1
17chondroma10.1
18extraosseous chondrosarcoma10.1
19keratoacanthoma10.1
20mesenchymal cell neoplasm10.1
21myxoid chondrosarcoma10.1
22periodontitis10.1
23thyroiditis10.1
24infantile myofibromatosis10.0DES
25fasciitis10.0ACTC1
26papilloma10.0ACTC1
27lymphangioleiomyomatosis10.0DES
28hemangioma10.0ACTC1
29alveolar soft part sarcoma10.0MYOD1
30atypical teratoid rhabdoid tumor10.0SMARCB1
31sertoli-leydig cell tumor10.0MUC1
32rhabdoid cancer10.0SMARCB1
33lipoma10.0DES
34gliosarcoma10.0GFAP
35giant cell glioblastoma10.0GFAP
36collecting duct carcinoma10.0SMARCB1
37pierre robin sequence10.0SOX9
38subependymal giant cell astrocytoma10.0GFAP
39cystadenocarcinoma10.0MUC1
40retroperitoneal leiomyosarcoma10.0SMARCB1
41malignant mesenchymoma10.0MYOD1, MYOG
42mixed glioma10.0GFAP
43histiocytosis10.0S100B
44fibrous meningioma10.0S100B, MUC1
45congenital mesoblastic nephroma10.0SMARCB1
46adenomatoid tumor10.0VIM
47myotonic dystrophy10.0MYOD1, MYOG
48desmoplastic small round cell tumor10.0MUC1, DES
49ganglioglioma10.0S100B, GFAP
50pineocytoma10.0GFAP, S100B

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Clinical Features for Mesenchymal Chondrosarcoma

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Drugs & Therapeutics for Mesenchymal Chondrosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mesenchymal Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Search CenterWatch for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

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Anatomical Context for Mesenchymal Chondrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

32
Bone, Lung, Kidney, Pancreas, Breast, Heart, Cerebellum, Thyroid, Spleen, Brain, Spinal cord, Skin

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1HEY1, SOX9, MYOD1, GFAP, ACTC1
2MP:00053818.6COL2A1, SOX9, MUC1, CDX1, GFAP, SMARCB1
3MP:00053918.3COL2A1, VIM, SOX9, MUC1, GFAP, SMARCB1
4MP:00053857.9COL2A1, VIM, HEY1, SOX9, DES, MYOD1
5MP:00053807.7COL2A1, VIM, HEY1, SOX9, NCOA2, MYOG
6MP:00053867.6COL2A1, VIM, S100B, SOX9, DES, NCOA2
7MP:00053767.4SOX9, DES, MYOD1, MYOG, MUC1, GFAP
8MP:00028737.4ACTC1, COL2A1, S100B, HEY1, SOX9, MYOD1
9MP:00107687.3SOX9, HEY1, VIM, COL2A1, DES, MYOD1
10MP:00053787.0COL2A1, VIM, HEY1, SOX9, NCOA2, MYOD1

Publications for Mesenchymal Chondrosarcoma

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50PubMed
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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 269)
idTitleAuthorsYear
1
Radiation Therapy Is Associated With Fewer Recurrences in Mesenchymal Chondrosarcoma. (23709273)
2013
2
Mesenchymal chondrosarcoma: a case report. (23966829)
2013
3
Primary extraskeletal mesenchymal chondrosarcoma of the vulva. (24328027)
2013
4
Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. (21615516)
2012
5
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. (23252872)
2012
6
Extraskeletal mesenchymal chondrosarcoma in the axillary region: reports of two cases. (23136576)
2012
7
Mesenchymal chondrosarcoma: clinicopathologic study of 20 cases. (22208489)
2012
8
A 71-year-old woman with an intracranial dural-based mesenchymal chondrosarcoma. (22658242)
2012
9
Extraskeletal intracranial mesenchymal chondrosarcoma: report of a rare case. (22234225)
2011
10
A fatal case of mesenchymal chondrosarcoma of the mandible. (21768711)
2011
11
Intracranial mesenchymal chondrosarcoma: report of two pediatric cases. (21125628)
2011
12
Maxillary radiolucency. Mesenchymal chondrosarcoma. (19903647)
2009
13
Congenital intracranial mesenchymal chondrosarcoma: case report and review of the literature in pediatric patients. (17990930)
2008
14
Mesenchymal chondrosarcoma of the talus: a case report. (17923063)
2007
15
Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. (17336849)
2007
16
Primary extraskeletal mesenchymal chondrosarcoma arising from the pancreas. (18071285)
2007
17
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
18
Extraskeletal mesenchymal chondrosarcoma of the kidney. (16643625)
2006
19
Intracranial extra-skeletal mesenchymal chondrosarcoma. (16977825)
2006
20
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. (15731776)
2005
21
Successful treatment of a chemoresistant tumor with temozolomide in an adult patient: report of a recurrent intracranial mesenchymal chondrosarcoma. (15735926)
2005
22
Intra-parenchymal mesenchymal chondrosarcoma of the cerebellum: case report and review of the literature. (16187026)
2005
23
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. (15203726)
2004
24
Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. (12792311)
2003
25
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. (12673561)
2003
26
Mesenchymal chondrosarcoma of the temporal bone. (12393044)
2002
27
Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. (12011263)
2002
28
A case of soft tissue mesenchymal chondrosarcoma metastatic to skin, clinically mimicking keratoacanthoma. (10446785)
1999
29
Mesenchymal chondrosarcoma associated with Goldenhar's syndrome. (10447638)
1999
30
Inhibitory effects of transforming growth factor-beta1 pretreatment on experimental pulmonary metastasis of MCS-1 Chinese hamster mesenchymal chondrosarcoma cells. (10458477)
1999
31
Mesenchymal chondrosarcoma and simulating lesions of the orbit. (10026739)
1999
32
Mesenchymal chondrosarcoma of the cerebellum. (8908319)
1996
33
Mesenchymal chondrosarcoma with secondary orbital invasion. (8541259)
1995
34
Mesenchymal chondrosarcoma of the maxilla. (7964146)
1994
35
Mesenchymal chondrosarcoma of the orbit. Report of three new cases and review of the literature. (8293407)
1994
36
Intracranial mesenchymal chondrosarcoma: a case report and literature review. (8252523)
1993
37
Mesenchymal chondrosarcoma arising in fibrous dysplasia of the femur. (8227418)
1993
38
Pathologic quiz case 2. Mesenchymal chondrosarcoma. (2306360)
1990
39
Extraskeletal mesenchymal chondrosarcoma in a cow. (2794151)
1989
40
Intracerebral mesenchymal chondrosarcoma. (2604377)
1989
41
Mesenchymal chondrosarcoma: report of a case. (3095275)
1986
42
Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. (3697943)
1986
43
Oncogenic osteomalacia associated with a mesenchymal chondrosarcoma. (6518684)
1984
44
A case of mesenchymal chondrosarcoma of the orbit. (7211271)
1980
45
Case report. Extraskeletal mesenchymal chondrosarcoma. (750463)
1978
46
Mesenchymal chondrosarcoma. A case report. (845214)
1977
47
A comparative ultrastructural study of mesenchymal chondrosarcoma and myxoid chondrosarcoma. (4834151)
1974
48
Mesenchymal chondrosarcoma. A study of the ultrastructure. (4356483)
1973
49
Extraskeletal mesenchymal chondrosarcoma. (4694076)
1973
50
Mesenchymal chondrosarcoma--observations on 30 new cases. (5096926)
1971

Genetic Variations for Mesenchymal Chondrosarcoma

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Expression for genes affiliated with Mesenchymal Chondrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Mesenchymal Chondrosarcoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1orcein449.8VIM, S100B, DES, ACTC1
2creatinine449.8MYOD1, GFAP, ACTC1
3procollagen449.7COL2A1, VIM, DES, ACTC1
4ganglioside449.7GFAP, DES, VIM
5biotin44 11 2411.7VIM, DES, MUC1, ACTC1
6eosin449.6GFAP, MUC1, S100B, VIM
7dbc-amp449.6VIM, S100B, GFAP
8acetylcholine44 49 28 11 2413.6MYOD1, MYOG, GFAP
9butyrate449.5GFAP, MYOG, MYOD1
10mucicarmine449.5VIM, S100B, DES, MUC1, ACTC1
11b 723449.5VIM, S100B, DES, MUC1, ACTC1
12matrigel449.4VIM, MUC1, GFAP, ACTC1
13chondroitin sulfate44 2410.4VIM, SOX9, GFAP
144-hydroxytamoxifen449.4NCOA2, S100B, VIM
15ribonucleic acid449.4SOX9, MYOG, MUC1, ACTC1
16ascorbic acid44 2410.3COL2A1, S100B, SOX9, MYOG
17ethanol44 49 11 2412.3GFAP, MUC1, DES, S100B
18iron44 2410.3VIM, S100B, DES, GFAP, ACTC1
19dihydrotestosterone44 28 11 2412.3MUC1, NCOA2, DES, VIM
20progestin449.3MUC1, DES, VIM
21methionine449.3GFAP, DES, S100B, VIM
22s 100449.2ACTC1, GFAP, MUC1, DES, S100B, VIM
23reticulin449.2VIM, S100B, DES, MUC1, GFAP, ACTC1
24hematoxylin449.1VIM, S100B, DES, MUC1, GFAP, ACTC1
25formaldehyde44 2410.1VIM, S100B, DES, MUC1, GFAP, ACTC1
26glycogen44 2410.1VIM, S100B, DES, MUC1, GFAP, ACTC1
27chloramphenicol44 2 1111.1COL2A1, VIM, S100B, MYOD1, MUC1
28forskolin44 49 1111.0GFAP, MUC1, MYOG, S100B, VIM
29adenylate449.0GFAP, MYOG, DES, S100B, VIM
3012-o-tetradecanoylphorbol 13-acetate448.9VIM, DES, MYOD1, MYOG, MUC1
31glutamine448.9VIM, S100B, SOX9, NCOA2, GFAP
32estradiol44 11 2410.9VIM, DES, NCOA2, MUC1, GFAP
33bromodeoxyuridine448.7VIM, S100B, DES, MYOD1, MYOG, GFAP
34lysine448.7COL2A1, VIM, DES, NCOA2, MYOD1
35steroid448.5SOX9, DES, NCOA2, MYOD1, MYOG, ACTC1
36progesterone44 59 28 11 2412.5VIM, S100B, DES, NCOA2, MUC1, GFAP
37zinc44 249.5COL2A1, S100B, SOX9, NCOA2, MYOD1, GFAP
38arginine448.2COL2A1, VIM, S100B, DES, NCOA2, MYOD1
39dexamethasone44 49 28 1111.2COL2A1, VIM, S100B, SOX9, NCOA2, MUC1
40paraffin448.2VIM, S100B, DES, MYOD1, MYOG, MUC1
41cysteine448.1COL2A1, VIM, S100B, DES, MYOD1, MYOG
42cyclic amp44 249.0VIM, S100B, SOX9, DES, NCOA2, MYOD1
43oxygen44 249.0COL2A1, S100B, SOX9, DES, MYOD1, MYOG
44vegf447.9VIM, S100B, SOX9, DES, MYOD1, MYOG
45glucose447.9S100B, DES, NCOA2, MYOD1, MYOG, MUC1
46serine447.8COL2A1, VIM, S100B, SOX9, DES, MYOD1
47tyrosine447.8S100B, DES, NCOA2, MYOD1, MYOG, MUC1
48estrogen447.5VIM, S100B, DES, NCOA2, MYOD1, MYOG
49testosterone44 59 11 2410.3VIM, S100B, SOX9, DES, NCOA2, MYOD1
50retinoic acid44 247.6COL2A1, VIM, S100B, SOX9, DES, NCOA2

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

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16Gene Ontology
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Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3GFAP, SYNM, DES, VIM

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.2SOX9, HEY1
2notochord developmentGO:03090310.1COL2A1, SOX9
3limb bud formationGO:06017410.0COL2A1, SOX9
4Bergmann glial cell differentiationGO:06002010.0VIM, GFAP
5tissue homeostasisGO:00189410.0SOX9, COL2A1
6astrocyte developmentGO:0140029.9GFAP, VIM
7muscle filament slidingGO:0300499.8ACTC1, DES, VIM
8intermediate filament organizationGO:0451099.8VIM, GFAP
9muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
10skeletal muscle fiber developmentGO:0487419.4MYOG, MYOD1
11cellular response to estradiol stimulusGO:0713929.2MYOG, MYOD1
12positive regulation of transcription from RNA polymerase II promoterGO:0459447.9SMARCB1, CDX1, MYOG, MYOD1, NCOA2, SOX9

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0GFAP, SYNM, DES, VIM
2protein bindingGO:0055155.9S100B, HEY1, SOX9, DES, NCOA2, SYNM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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Sources for Mesenchymal Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet