Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 14
Chondrosarcoma, Mesenchymal 41 69
Chondrosarcoma Mesenchymal 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 41 D018211
NCIt 46 C3737
SNOMED-CT 64 56565002
UMLS 69 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to meninges hemangiopericytoma and hemangiopericytoma, malignant, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cellular and embryo

Wikipedia : 72 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 meninges hemangiopericytoma 29.5 HEY1 NCOA2 VIM
2 hemangiopericytoma, malignant 29.4 DES MUC1 VIM
3 chondromyxoid fibroma 29.4 DES SOX9 VIM
4 adult mesenchymal chondrosarcoma 12.4
5 extraskeletal mesenchymal chondrosarcoma 12.4
6 pediatric mesenchymal chondrosarcoma 12.2
7 chondrosarcoma 11.0
8 periosteal chondrosarcoma 10.3 HEY1 NCOA2
9 spindle cell thymoma 10.3 DES MUC1
10 myxofibrosarcoma 10.3 DES MUC1
11 ischemic fasciitis 10.3 DES MUC1
12 plasmablastic lymphoma 10.3 DES MUC1
13 proximal spinal muscular atrophy 10.3 DES MUC1
14 skin glomus tumor 10.2 DES VIM
15 infantile digital fibromatosis 10.2 DES VIM
16 lymphangiomatosis 10.2 DES VIM
17 angiolipoma 10.2 DES VIM
18 primitive neuroectodermal tumor of the cervix uteri 10.2 DES VIM
19 cutaneous leiomyosarcoma 10.2 DES VIM
20 spindle cell lipoma 10.2 DES VIM
21 epulis 10.2 DES VIM
22 epithelioid leiomyosarcoma 10.2 DES VIM
23 benign metastasizing leiomyoma 10.2 DES VIM
24 congenital fibrosarcoma 10.2 DES VIM
25 juvenile xanthogranuloma 10.2 DES VIM
26 cutaneous fibrous histiocytoma 10.2 DES VIM
27 pseudosarcomatous fibromatosis 10.1 DES VIM
28 glomus tumor 10.1 DES VIM
29 malignant peritoneal mesothelioma 10.1 MUC1 VIM
30 papillary tumor of the pineal region 10.1 MUC1 VIM
31 granular cell tumor 10.1 DES VIM
32 congenital epulis 10.1 DES VIM
33 fibrous meningioma 10.1 MUC1 VIM
34 chordoid meningioma 10.1 MUC1 VIM
35 malignant mixed mullerian tumor 10.1 MUC1 VIM
36 meningitis 10.1
37 nodular hidradenoma 10.1 MUC1 VIM
38 embryonal sarcoma 10.1 DES VIM
39 clear cell meningioma 10.1 MUC1 VIM
40 eccrine porocarcinoma 10.1 MUC1 VIM
41 infantile myofibromatosis 10.1 DES VIM
42 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
43 adenofibroma 10.1 MUC1 VIM
44 smooth muscle tumor 10.1 DES VIM
45 myxopapillary ependymoma 10.1 MUC1 VIM
46 monophasic synovial sarcoma 10.1 MUC1 VIM
47 sarcomatoid mesothelioma 10.1 MUC1 VIM
48 anaplastic ependymoma 10.1 MUC1 VIM
49 hidradenoma 10.1 MUC1 VIM
50 sertoli cell tumor 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX1 DES HEY1 NCOA2 SOX9 VIM
2 embryo MP:0005380 9.1 VIM CDX1 HEY1 IRF2BP2 NCOA2 SOX9

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Isophosphamide mustard Phase 2, Phase 3 0
10 Topoisomerase Inhibitors Phase 2, Phase 3
11
Everolimus Approved Phase 2 159351-69-6 6442177
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
14 Antifungal Agents Phase 2
15 Anti-Infective Agents Phase 2
16 Antirheumatic Agents Phase 2
17 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

38
Bone, Kidney, Lung, Pancreas, Thyroid, Heart, Spleen

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 317)
# Title Authors Year
1
18F-FDG PET/CT Findings of Mesenchymal Chondrosarcoma of the Orbit. ( 29215408 )
2018
2
Mesenchymal Chondrosarcoma of the Lacrimal Gland. ( 29342030 )
2018
3
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
4
Periosteal mesenchymal chondrosarcoma of the tibia. ( 29397433 )
2018
5
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
6
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review. ( 29143958 )
2017
7
Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. ( 29044531 )
2017
8
Extraskeletal orbital mesenchymal chondrosarcoma: surgical approach and mini review. ( 28258179 )
2017
9
Primary Spinal Intradural Mesenchymal Chondrosarcoma with Several Local Regrowths Treated with Osteoplastic Laminotomies: A Case Report. ( 28825035 )
2017
10
Extraskeletal mesenchymal chondrosarcoma at unusual location involving spleen and kidney with review of literature. ( 28631650 )
2017
11
Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Clinical Mimicry as Glomus Jugulare. ( 28867901 )
2017
12
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 28917072 )
2017
13
A Huge Mass in a Boy's Chest: An Unusual Case of Mesenchymal Chondrosarcoma. ( 29229475 )
2017
14
Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28352960 )
2017
15
Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. ( 28271053 )
2017
16
What Is Your Diagnosis? Extraskeletal mesenchymal chondrosarcoma. ( 28857701 )
2017
17
Mesenchymal chondrosarcoma of the orbit: A case report with 5A years of follow-up. ( 28812954 )
2017
18
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma. ( 28042016 )
2016
19
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
20
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case. ( 28164050 )
2016
21
Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. ( 27544802 )
2016
22
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. ( 27487949 )
2016
23
CORR Insights(Ar): Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2016
24
Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 26975384 )
2016
25
Mesenchymal chondrosarcoma of mandible. ( 27721626 )
2016
26
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
27
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. ( 27617402 )
2016
28
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
29
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
30
Maxillary mesenchymal chondrosarcoma presenting with epistaxis in a child. ( 26629302 )
2015
31
Intraoperative high-field magnetic resonance imaging combined with neuronavigation-guided resection of intracranial mesenchymal chondrosarcoma in Broca's area: a rare case report and literature review. ( 26064406 )
2015
32
Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma. ( 26556438 )
2015
33
A Case of Mesenchymal Chondrosarcoma Arising from the Femoral Vein with 8A Years of Follow-up. ( 26133997 )
2015
34
Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. ( 25849226 )
2015
35
Mesenchymal chondrosarcoma: prognostic factors and outcome in 113 patients. A European Musculoskeletal Oncology Society study. ( 25529371 )
2015
36
Primary renal mesenchymal chondrosarcoma: a case report. ( 25733289 )
2015
37
An extraordinary case of mesenchymal chondrosarcoma metastasis in the thyroid. ( 25510635 )
2015
38
Imaging features of extraskeletal mesenchymal chondrosarcoma of the hand. ( 25797212 )
2015
39
Primary mesenchymal chondrosarcoma with bilateral kidney invasion and calcification in renal pelvis: A case report and review of the literature. ( 26622628 )
2015
40
A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. ( 25838713 )
2015
41
Intraparenchymal mesenchymal chondrosarcoma of the frontal lobe - a case report and molecular detection of specific gene fusions from archival FFPE sample. ( 25907264 )
2015
42
Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review. ( 26146478 )
2015
43
Chemotherapy improved prognosis of mesenchymal chondrosarcoma with rare metastasis to the pancreas. ( 24716041 )
2014
44
Mesenchymal chondrosarcoma of the mandible: a rare malignant tumor. ( 25255353 )
2014
45
Mesenchymal chondrosarcoma diagnosed on FISH for HEY1-NCOA2 fusion gene. ( 25336010 )
2014
46
Mesenchymal chondrosarcoma of mandible: A rare case report and review. ( 25364172 )
2014
47
Extraskeletal intraspinal mesenchymal chondrosarcoma; 18F-FDG PET/CT finding. ( 23877507 )
2014
48
Mesenchymal chondrosarcoma of posterior maxilla: report of a case with brief literature review. ( 25031908 )
2014
49
Mesenchymal chondrosarcoma of the right buccal region: A case report and review of the literature. ( 25364427 )
2014
50
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. ( 24932271 )
2014

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 DES MUC1 VIM
2 11.11 DES VIM
3 10.92 CDX1 SOX9 VIM
4
Show member pathways
10.61 DES VIM

GO Terms for Mesenchymal Chondrosarcoma

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 CDX1 HEY1 NCOA2 SOX9
2 muscle filament sliding GO:0030049 9.16 DES VIM
3 intermediate filament organization GO:0045109 8.96 DES VIM
4 endocardial cushion morphogenesis GO:0003203 8.62 HEY1 SOX9

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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