MCID: MSN005
MIFTS: 42

Mesenchymal Chondrosarcoma malady

Summaries for Mesenchymal Chondrosarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to extraskeletal mesenchymal chondrosarcoma and intracranial chondrosarcoma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Striated Muscle Contraction and Neural Crest Differentiation. The compounds orcein and creatinine have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

mesenchymal chondrosarcoma 8 10
chondrosarcoma, mesenchymal 61
chondrosarcoma mesenchymal 45


External Ids:

Disease Ontology8 DOID:4545
MeSH35 D018211
SNOMED-CT57 56565002
NCIt40 C3737

Related Diseases for Mesenchymal Chondrosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Mesenchymal Chondrosarcoma family:

adult mesenchymal chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1extraskeletal mesenchymal chondrosarcoma10.9
2intracranial chondrosarcoma10.8
3pediatric mesenchymal chondrosarcoma10.6
4adult mesenchymal chondrosarcoma10.5
5osteomalacia10.3
6small cell sarcoma10.3
7goldenhar syndrome10.1
8chondroblastoma10.1
9fibrous dysplasia10.1
10bone osteosarcoma10.1
11aneurysmal bone cysts10.1
12oncogenic osteomalacia10.1
13osteomalacia, tumor-induced10.1
14infantile myofibromatosis10.0DES
15fasciitis10.0ACTC1
16papilloma10.0ACTC1
17lymphangioleiomyomatosis10.0DES
18hemangioma10.0ACTC1
19alveolar soft part sarcoma10.0MYOD1
20atypical teratoid rhabdoid tumor10.0SMARCB1
21sertoli-leydig cell tumor10.0MUC1
22rhabdoid cancer10.0SMARCB1
23lipoma10.0DES
24gliosarcoma10.0GFAP
25giant cell glioblastoma10.0GFAP
26collecting duct carcinoma10.0SMARCB1
27pierre robin sequence10.0SOX9
28subependymal giant cell astrocytoma10.0GFAP
29cystadenocarcinoma10.0MUC1
30retroperitoneal leiomyosarcoma10.0SMARCB1
31malignant mesenchymoma10.0MYOG, MYOD1
32mixed glioma10.0GFAP
33osteosarcoma10.0SOX9, MYOD1
34histiocytosis10.0S100B
35fibrous meningioma10.0MUC1, S100B
36congenital mesoblastic nephroma10.0SMARCB1
37adenomatoid tumor10.0VIM
38myotonic dystrophy10.0MYOG, MYOD1
39desmoplastic small round cell tumor10.0DES, MUC1
40ganglioglioma10.0GFAP, S100B
41pineocytoma10.0S100B, GFAP
42neurilemmoma10.0SMARCB1, GFAP
43paraganglioma10.0S100B, GFAP
44adenosarcoma10.0ACTC1, DES
45myxopapillary ependymoma10.0S100B, GFAP
46cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES
47papillary ependymoma10.0S100B, GFAP
48hidradenoma10.0MUC1
49alveolar rhabdomyosarcoma10.0MYOG, MYOD1, DES
50choroid plexus carcinoma10.0GFAP, S100B

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Clinical Features for Mesenchymal Chondrosarcoma

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mesenchymal Chondrosarcoma

Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Search CenterWatch for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mesenchymal Chondrosarcoma

Sources:
51PubMed
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Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
Extraskeletal intraspinal mesenchymal chondrosarcoma; 18F-FDG PET/CT finding. (23877507)
2014
2
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
3
Intraparenchymal mesenchymal chondrosarcoma in an unusual location. (22406804)
2012
4
Primary orbital mesenchymal chondrosarcoma: case report and review of the literature. (22761622)
2012
5
Extraskeletal mesenchymal chondrosarcoma of the pleura: report of a rare case. (21393900)
2011
6
Invasion of lung mesenchymal chondrosarcoma into the left atrium via the pulmonary vein detected on transoesophageal echocardiography. (21642279)
2011
7
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. (20138330)
2010
8
Primary orbital mesenchymal chondrosarcoma: a case report and literature review. (18188507)
2009
9
Mesenchymal chondrosarcoma mimicking apical periodontitis. (18928860)
2008
10
Retroperitoneal mesenchymal chondrosarcoma mimicking a large retroperitoneal sacral schwannoma. (17912561)
2008
11
Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model. (18974149)
2008
12
Mesenchymal chondrosarcoma of the left coronoid process: report of a unique case with clinical, histopathologic, and immunohistochemical findings, and a review of the literature. (17432791)
2007
13
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
14
Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue]. (17068623)
2006
15
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
16
Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. (15511276)
2004
17
Imprint cytology of extraskeletal mesenchymal chondrosarcoma of the perineum: a case report. (15471258)
2004
18
Extraskeletal mesenchymal chondrosarcoma: case report. (12727057)
2003
19
Mesenchymal chondrosarcoma presenting as an external auditory canal mass. (12621355)
2003
20
Spinal meningeal mesenchymal chondrosarcoma. Report of a new case and review of the literature. (14618139)
2003
21
Mesenchymal chondrosarcoma of soft tissues of the calf. (11334455)
2001
22
Mesenchymal chondrosarcoma of the kidney. (11696762)
2001
23
Primary intracerebral mesenchymal chondrosarcoma with rhabdomyosarcomatous differentiation: case report and literature review. (11708546)
2001
24
Overexpression of p53 and rare genetic mutation in mesenchymal chondrosarcoma. (10948336)
2000
25
Mutational alterations of the p16CDKN2A tumor suppressor gene have low incidence in mesenchymal chondrosarcoma. (11061340)
2000
26
Tumor-induced osteomalacia and symptomatic looser zones secondary to mesenchymal chondrosarcoma. (10362094)
1999
27
Mesenchymal chondrosarcoma of the mandible: case report and review of the literature. (9437988)
1998
28
Mesenchymal chondrosarcoma of the cervical spine in a child. (9113295)
1997
29
Mesenchymal chondrosarcoma of the maxilla. A case report. (9180232)
1997
30
Mesenchymal chondrosarcoma of the foot, an unusual location: case report and review of the literature. (8531853)
1996
31
Mesenchymal chondrosarcoma in anterior skull base: case report. (8916127)
1996
32
Mesenchymal chondrosarcoma. A cytogenetic, immunohistochemical and ultrastructural study. (7656206)
1995
33
Extraskeletal mesenchymal chondrosarcoma of the orbit. (8374880)
1993
34
A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region. (1487666)
1992
35
Extraosseus uptake with bone scintigraphy. Renal mesenchymal chondrosarcoma with metastasis. (2054997)
1991
36
Retroperitoneal mesenchymal chondrosarcoma. Report of a case diagnosed by fine needle aspiration cytology. (2375221)
1990
37
Extraskeletal mesenchymal chondrosarcoma of the mediastinum. (2242853)
1990
38
Mesenchymal chondrosarcoma of the ethmoid sinus. (2594337)
1989
39
Case report 517. Mesenchymal chondrosarcoma of the femur. (2749290)
1989
40
Pediatric case of the day. Mesenchymal chondrosarcoma. (3448648)
1987
41
Intracranial mesenchymal chondrosarcoma. (3120541)
1987
42
Intraspinal mesenchymal chondrosarcoma in a three-year-old boy. (3506147)
1987
43
Extraskeletal mesenchymal chondrosarcoma: case report and review of the literature. (2409241)
1985
44
Retroperitoneal mesenchymal chondrosarcoma. (4056423)
1985
45
Ultrastructure of cartilaginous tumors and S-100 protein in the tumors. With reference to the histogenesis of chondroblastoma, chondromyxoid fibroma and mesenchymal chondrosarcoma. (6524378)
1984
46
Case report 127: mesenchymal chondrosarcoma of soft tissues of thigh. (7209584)
1980
47
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. (753003)
1978
48
Mesenchymal chondrosarcoma: report of case. (4524570)
1974
49
Primary non-skeletal intracranial cartilaginous neoplasms: report of a chondroma and a mesenchymal chondrosarcoma. (5505673)
1970
50
Post-irradiation mesenchymal chondrosarcoma. A case report. (4378177)
1967

Genetic Variations for Mesenchymal Chondrosarcoma

Expression for genes affiliated with Mesenchymal Chondrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Mesenchymal Chondrosarcoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1orcein459.8VIM, ACTC1, DES, S100B
2creatinine459.8GFAP, MYOD1, ACTC1
3procollagen459.7COL2A1, VIM, DES, ACTC1
4ganglioside459.7DES, GFAP, VIM
5biotin45 11 2411.7VIM, MUC1, ACTC1, DES
6eosin459.6VIM, GFAP, MUC1, S100B
7dbc-amp459.6VIM, GFAP, S100B
8acetylcholine45 50 29 11 2413.6MYOG, MYOD1, GFAP
9butyrate459.5MYOG, GFAP, MYOD1
10mucicarmine459.5ACTC1, VIM, MUC1, DES, S100B
11b 723459.5S100B, VIM, DES, MUC1, ACTC1
12matrigel459.4GFAP, ACTC1, MUC1, VIM
13chondroitin sulfate45 2410.4SOX9, VIM, GFAP
144-hydroxytamoxifen459.4NCOA2, S100B, VIM
15ribonucleic acid459.4SOX9, MYOG, MUC1, ACTC1
16ascorbic acid45 2410.3S100B, MYOG, COL2A1, SOX9
17ethanol45 50 11 2412.3GFAP, MUC1, DES, S100B
18iron45 2410.3GFAP, ACTC1, DES, S100B, VIM
19dihydrotestosterone45 29 11 2412.3NCOA2, DES, MUC1, VIM
20progestin459.3DES, MUC1, VIM
21methionine459.3VIM, DES, S100B, GFAP
22s 100459.2S100B, DES, MUC1, GFAP, ACTC1, VIM
23reticulin459.2MUC1, ACTC1, GFAP, DES, S100B, VIM
24hematoxylin459.1MUC1, DES, ACTC1, VIM, S100B, GFAP
25formaldehyde45 2410.1S100B, ACTC1, GFAP, MUC1, DES, VIM
26glycogen45 2410.1GFAP, VIM, S100B, DES, MUC1, ACTC1
27chloramphenicol45 2 1111.1MYOD1, COL2A1, VIM, MUC1, S100B
28forskolin45 50 1111.0S100B, GFAP, MUC1, VIM, MYOG
29adenylate459.0GFAP, MYOG, DES, VIM, S100B
3012-o-tetradecanoylphorbol 13-acetate458.9MYOG, MUC1, VIM, MYOD1, DES
31glutamine458.9VIM, S100B, SOX9, NCOA2, GFAP
32estradiol45 11 2410.9NCOA2, GFAP, VIM, DES, MUC1
33bromodeoxyuridine458.7MYOG, GFAP, DES, S100B, VIM, MYOD1
34lysine458.7COL2A1, VIM, DES, NCOA2, MYOD1
35steroid458.5NCOA2, SOX9, MYOD1, MYOG, ACTC1, DES
36progesterone45 60 29 11 2412.5NCOA2, S100B, GFAP, ACTC1, VIM, DES
37zinc45 249.5SOX9, S100B, NCOA2, MYOD1, COL2A1, GFAP
38arginine458.2S100B, GFAP, VIM, NCOA2, MYOD1, COL2A1
39dexamethasone45 50 29 1111.2ACTC1, GFAP, MUC1, NCOA2, SOX9, VIM
40paraffin458.2S100B, VIM, MYOD1, MYOG, MUC1, GFAP
41cysteine458.1COL2A1, VIM, MYOG, DES, MUC1, GFAP
42cyclic amp45 249.0GFAP, MUC1, MYOD1, NCOA2, DES, SOX9
43oxygen45 249.0ACTC1, GFAP, MUC1, MYOG, MYOD1, DES
44vegf457.9GFAP, MYOD1, MYOG, MUC1, ACTC1, DES
45glucose457.9DES, MYOG, S100B, NCOA2, MYOD1, GFAP
46serine457.8VIM, DES, SOX9, S100B, GFAP, MUC1
47tyrosine457.8GFAP, MYOD1, DES, S100B, MUC1, MYOG
48estrogen457.5S100B, VIM, DES, MYOD1, NCOA2, MYOG
49testosterone45 60 11 2410.3ACTC1, SOX9, VIM, S100B, DES, NCOA2
50retinoic acid45 247.6COL2A1, VIM, S100B, SOX9, DES, MYOG

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3GFAP, SYNM, DES, VIM

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.1HEY1, SOX9
2notochord developmentGO:03090310.1SOX9, COL2A1
3limb bud formationGO:06017410.0COL2A1, SOX9
4Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
5tissue homeostasisGO:00189410.0COL2A1, SOX9
6astrocyte developmentGO:0140029.9VIM, GFAP
7muscle filament slidingGO:0300499.8DES, ACTC1, VIM
8intermediate filament organizationGO:0451099.8VIM, GFAP
9muscle cell fate commitmentGO:0426939.7MYOG, MYOD1
10skeletal muscle fiber developmentGO:0487419.4MYOG, MYOD1
11cellular response to estradiol stimulusGO:0713929.2MYOG, MYOD1
12positive regulation of transcription from RNA polymerase II promoterGO:0459447.9SMARCB1, MYOD1, MYOG, CDX1, SOX9, HEY1

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0GFAP, SYNM, DES, VIM
2protein bindingGO:0055155.9S100B, HEY1, SOX9, DES, NCOA2, SYNM

Products for genes affiliated with Mesenchymal Chondrosarcoma

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  • Proteins
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Sources for Mesenchymal Chondrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet