MCID: MSN005
MIFTS: 52

Mesenchymal Chondrosarcoma malady

Summaries for Mesenchymal Chondrosarcoma

About this section


Wikipedia:65 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

MalaCards based summary: Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and sarcoma. An important gene associated with Mesenchymal Chondrosarcoma is SSX1 (synovial sarcoma, X breakpoint 1), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Striated Muscle Contraction. The compounds orcein and biotin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related mouse phenotypes are vision/eye and digestive/alimentary.

Aliases & Classifications for Mesenchymal Chondrosarcoma

About this section
Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Mesenchymal Chondrosarcoma, Aliases & Descriptions:

Name: Mesenchymal Chondrosarcoma 10 12
Chondrosarcoma, Mesenchymal 62
 
Chondrosarcoma Mesenchymal 45


External Ids:

Disease Ontology10 DOID:4545
NCIt40 C3737
SNOMED-CT57 56565002
MeSH35 D018211

Related Diseases for Mesenchymal Chondrosarcoma

About this section

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma32.0S100B, MUC1, VIM, SOX9, DES
2sarcoma30.3DES, SMARCB1, VIM, MYOD1, MYOG, MUC1
3fibroma30.2DES, VIM, ACTC1
4hemangiopericytoma30.1DES, VIM, MUC1, ACTC1, S100B
5extraskeletal mesenchymal chondrosarcoma11.0
6meningitis10.5
7adult mesenchymal chondrosarcoma10.4
8pediatric mesenchymal chondrosarcoma10.4
9cervicitis10.4
10osteomalacia10.3
11thyroiditis10.3
12aneurysmal bone cysts10.1
13ewing sarcoma10.1
14chondroblastoma10.1
15small cell sarcoma10.1
16meninges hemangiopericytoma10.1
17fibrous dysplasia10.1
18chondroma10.1
19keratoacanthoma10.1
20myxoid chondrosarcoma10.1
21periodontitis10.1
22oncogenic osteomalacia10.1
23aneurysm10.1
24chondromyxoid fibroma10.1
25infantile myofibromatosis10.1DES
26alveolar soft-part sarcoma10.1MYOD1
27fasciitis10.1ACTC1
28hidradenoma10.1MUC1
29retroperitoneal leiomyosarcoma10.1SMARCB1
30subependymal giant cell astrocytoma10.1GFAP
31cystadenocarcinoma10.0MUC1
32giant cell glioblastoma10.0GFAP
33congenital mesoblastic nephroma10.0SMARCB1
34myoma10.0DES, MYOG
35malignant mesenchymoma10.0MYOD1, MYOG
36mixed glioma10.0GFAP
37sarcoma, synovial10.0SSX1
38desmoplastic small round cell tumor10.0MUC1, DES
39desmoid disease, hereditary10.0DES, ACTC1
40fibrous meningioma10.0S100B, MUC1
41histiocytosis10.0S100B
42adenosarcoma10.0ACTC1, DES
43alexander disease10.0DES, GFAP
44myopathy congenital10.0MYOG, DES
45rhabdomyosarcoma 2, alveolar10.0DES, MYOD1, MYOG
46adenomatoid tumor10.0VIM
47pineocytoma10.0GFAP, S100B
48cutaneous fibrous histiocytoma10.0DES, ACTC1, S100B
49neurilemmoma10.0SMARCB1, GFAP
50ganglioglioma10.0S100B, GFAP

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to mesenchymal chondrosarcoma

Symptoms for Mesenchymal Chondrosarcoma

About this section

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Mesenchymal Chondrosarcoma

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Genetic Tests for Mesenchymal Chondrosarcoma

About this section

Anatomical Context for Mesenchymal Chondrosarcoma

About this section

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

33
Bone, Kidney, Lung, Pancreas, Cerebellum, Heart, Thyroid, Spleen, Brain, Spinal cord, Breast, Skin, Uterus

Animal Models for Mesenchymal Chondrosarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5COL2A1, MUC1, VIM, SOX9, GFAP, SMARCB1
2MP:00053818.4SMARCB1, GFAP, SOX9, MUC1, COL2A1, CDX1
3MP:00053697.8DES, GFAP, SOX9, HEY1, VIM, MYOD1
4MP:00053857.6DES, SMARCB1, GFAP, SOX9, HEY1, VIM
5MP:00053807.5SMARCB1, SOX9, HEY1, VIM, MYOG, COL2A1
6MP:00028737.3CDX1, GFAP, SOX9, HEY1, MYOD1, MYOG
7MP:00053767.2DES, SMARCB1, GFAP, SOX9, VIM, MYOD1
8MP:00053867.1DES, GFAP, SOX9, VIM, MYOG, COL2A1
9MP:00107687.0SOX9, GFAP, SMARCB1, DES, HEY1, VIM
10MP:00053786.4SMARCB1, GFAP, SOX9, HEY1, VIM, MYOD1

Publications for Mesenchymal Chondrosarcoma

About this section

Articles related to Mesenchymal Chondrosarcoma:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
Primary spinal intradural mesenchymal chondrosarcoma with detection of fusion gene HEY1-NCOA2: A paediatric case report and review of the literature. (25202377)
2014
2
Primary spinal extra-osseous intradural mesenchymal chondrosarcoma in a young boy. (24082926)
2013
3
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. (24255641)
2013
4
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion. (24124145)
2013
5
Intraparenchymal mesenchymal chondrosarcoma in an unusual location. (22406804)
2012
6
Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. (21615516)
2012
7
Primary mesenchymal chondrosarcoma of the kidney with synchronous implant and infiltrating urothelial carcinoma of the ureter. (22999069)
2012
8
Mesenchymal chondrosarcoma of the orbit: CT and MRI findings. (22177886)
2012
9
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma. (23252872)
2012
10
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature. (22535612)
2012
11
Extraskeletal intracranial mesenchymal chondrosarcoma: report of a rare case. (22234225)
2011
12
Intramuscular, extraskeletal mesenchymal chondrosarcoma. (23548257)
2011
13
Mesenchymal chondrosarcoma of the cervical spine: A case report. (23393533)
2011
14
Sacral mesenchymal chondrosarcoma in childhood: a case report and review of the literature. (20677924)
2010
15
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. (20138330)
2010
16
Primary orbital mesenchymal chondrosarcoma: a case report and literature review. (18188507)
2009
17
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. (20014564)
2009
18
Mesenchymal chondrosarcoma mimicking apical periodontitis. (18928860)
2008
19
Mesenchymal chondrosarcoma of the maxilla: case report and literature review. (17517320)
2007
20
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
21
Mesenchymal chondrosarcoma of the orbit. (16985424)
2006
22
Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. (16622368)
2006
23
Primary intraspinal mesenchymal chondrosarcoma: report of one case. (16640007)
2005
24
Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. (15511276)
2004
25
Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. (15203726)
2004
26
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. (12817616)
2003
27
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. (10626952)
2000
28
Mesenchymal chondrosarcoma of the jaws. Report of four cases. (9804199)
1998
29
Extraskeletal mesenchymal chondrosarcoma of the labium majus. (8774664)
1996
30
Mesenchymal chondrosarcoma of the maxilla. (7964146)
1994
31
Extraskeletal mesenchymal chondrosarcoma of the orbit. (8374880)
1993
32
A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region. (1487666)
1992
33
Mesenchymal chondrosarcoma of the maxilla. Report of a case. (2019783)
1991
34
Pathologic quiz case 2. Mesenchymal chondrosarcoma. (2306360)
1990
35
Mesenchymal chondrosarcoma of the maxilla: report of a case. (3049993)
1988
36
Case report 484: Mesenchymal chondrosarcoma of the left fifth rib. (3212495)
1988
37
Mesenchymal chondrosarcoma: a case report. (3467042)
1987
38
Mesenchymal chondrosarcoma: report of a case. (3095275)
1986
39
Mesenchymal chondrosarcoma of the kidney. (6498739)
1984
40
A rare cause of spinal cord compression in childhood from intraspinal mesenchymal chondrosarcoma. A report of two cases and review of the literature. (6462441)
1984
41
Preoperative Sterispon embolisation to facilitate wide excision of mesenchymal chondrosarcoma of the ribs. (6463923)
1984
42
Mesenchymal chondrosarcoma in the young. (6402853)
1983
43
Mesenchymal chondrosarcoma. A clinicopathologic analysis of 35 patients with emphasis on treatment. (6825046)
1983
44
Case report 134. Mesenchymal chondrosarcoma of the right side of the pelvis and thigh. (7466420)
1981
45
Case report. Extraskeletal mesenchymal chondrosarcoma. (750463)
1978
46
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. (753003)
1978
47
Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. (365318)
1978
48
Mesenchymal chondrosarcoma of the orbit. (4451652)
1974
49
Intracranial mesenchymal chondrosarcoma. (4699884)
1973
50
Mesenchymal chondrosarcoma. (5049459)
1972

Variations for Mesenchymal Chondrosarcoma

About this section

Expression for genes affiliated with Mesenchymal Chondrosarcoma

About this section

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for genes affiliated with Mesenchymal Chondrosarcoma

About this section

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.6CDX1, COL2A1, ACTC1
2
Show member pathways
9.6ACTC1, VIM, DES
39.5COL2A1, SOX9, GFAP
4
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2SYNM, VIM, GFAP, DES
59.1GFAP, SOX9, VIM, COL2A1
68.9CDX1, NCOA2, MYOG
7
Show member pathways
8.6DES, GFAP, SOX9, VIM, MUC1, COL2A1
8
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
8.5MYOD1, MYOG, NCOA2

Compounds for genes affiliated with Mesenchymal Chondrosarcoma

About this section

Compounds related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1orcein459.7DES, VIM, ACTC1, S100B
2biotin45 26 1311.6DES, VIM, MUC1, ACTC1
3eosin459.6GFAP, VIM, MUC1, S100B
4procollagen459.6DES, VIM, ACTC1, COL2A1
5ganglioside459.5VIM, GFAP, DES
6chondroitin sulfate45 2610.5VIM, SOX9, GFAP
7mucicarmine459.4DES, VIM, MUC1, ACTC1, S100B
8b 723459.4S100B, ACTC1, MUC1, VIM, DES
9matrigel459.4GFAP, VIM, MUC1, ACTC1
10ribonucleic acid459.3SOX9, MYOG, MUC1, ACTC1
11dbc-amp459.3GFAP, VIM, S100B
12methionine459.2S100B, VIM, GFAP, DES
13iron45 2610.2S100B, ACTC1, VIM, GFAP, DES
14ascorbic acid45 2610.2S100B, COL2A1, MYOG, SOX9
15s 100459.1S100B, ACTC1, MUC1, VIM, GFAP, DES
16reticulin459.1DES, GFAP, VIM, MUC1, ACTC1, S100B
17hematoxylin459.1DES, GFAP, VIM, MUC1, ACTC1, S100B
184-hydroxytamoxifen459.1VIM, S100B, NCOA2
19formaldehyde45 2610.1DES, GFAP, VIM, MUC1, ACTC1, S100B
20dihydrotestosterone45 30 26 1312.0NCOA2, MUC1, VIM, DES
21glycogen45 2610.0DES, GFAP, VIM, MUC1, ACTC1, S100B
22ethanol45 51 26 1312.0S100B, MUC1, GFAP, DES
23forskolin45 51 1310.9GFAP, VIM, MYOG, MUC1, S100B
24adenylate458.9DES, GFAP, VIM, MYOG, S100B
25chloramphenicol45 3 51 1311.8VIM, MYOD1, MUC1, COL2A1, S100B
2612-o-tetradecanoylphorbol 13-acetate458.7MUC1, MYOG, MYOD1, VIM, DES
27estradiol45 26 1310.7DES, GFAP, VIM, MUC1, NCOA2
28butyrate458.6GFAP, VIM, MYOD1, MYOG, MUC1
29glutamine458.6GFAP, SOX9, VIM, S100B, NCOA2
30bromodeoxyuridine458.5DES, GFAP, VIM, MYOD1, MYOG, S100B
31acetylcholine45 51 30 26 1312.4DES, GFAP, VIM, MYOD1, MYOG, S100B
32lysine458.3DES, VIM, MYOD1, COL2A1, NCOA2
33progesterone45 30 61 26 1312.2DES, GFAP, VIM, MUC1, ACTC1, S100B
34zinc45 269.0GFAP, SOX9, MYOD1, COL2A1, S100B, NCOA2
35paraffin457.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
36creatinine457.9DES, GFAP, VIM, MYOD1, MYOG, MUC1
37dexamethasone45 51 30 1310.8GFAP, SOX9, VIM, MUC1, ACTC1, COL2A1
38steroid457.8DES, SOX9, MYOD1, MYOG, ACTC1, S100B
39cysteine457.8DES, GFAP, VIM, MYOD1, MYOG, MUC1
40calcium45 51 26 1310.8DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
41arginine457.7DES, GFAP, VIM, MYOD1, COL2A1, S100B
42oxygen45 268.7DES, GFAP, SOX9, MYOD1, MYOG, MUC1
43vegf457.7DES, GFAP, SOX9, VIM, MYOD1, MYOG
44cyclic amp45 268.6DES, GFAP, SOX9, VIM, MYOD1, MUC1
45serine457.5DES, GFAP, SOX9, VIM, MYOD1, MYOG
46glucose457.5DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
47tyrosine457.4DES, GFAP, MYOD1, MYOG, MUC1, ACTC1
48estrogen457.1DES, GFAP, VIM, MYOD1, MYOG, MUC1
49testosterone45 61 26 139.9DES, GFAP, SOX9, VIM, MYOD1, MYOG
50retinoic acid45 267.3DES, GFAP, SOX9, VIM, MYOD1, MYOG

GO Terms for genes affiliated with Mesenchymal Chondrosarcoma

About this section

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.1SYNM, VIM, GFAP, DES
2nucleoplasmGO:00056548.0HEY1, MYOD1, MYOG, NCOA2, SMARCB1
3nucleusGO:00056346.5SMARCB1, NUP107, SOX9, HEY1, MYOD1, MYOG

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:000320310.2SOX9, HEY1
2notochord developmentGO:003090310.1COL2A1, SOX9
3limb bud formationGO:006017410.1SOX9, COL2A1
4Bergmann glial cell differentiationGO:006002010.0GFAP, VIM
5astrocyte developmentGO:001400210.0GFAP, VIM
6intermediate filament organizationGO:00451099.9VIM, GFAP
7tissue homeostasisGO:00018949.9SOX9, COL2A1
8muscle filament slidingGO:00300499.9ACTC1, VIM, DES
9cartilage condensationGO:00015029.8COL2A1, SOX9
10cellular response to glucocorticoid stimulusGO:00713859.8MYOD1, HEY1
11long-term synaptic potentiationGO:00602919.7S100B, GFAP
12negative regulation of neuron projection developmentGO:00109779.7VIM, GFAP
13muscle cell fate commitmentGO:00426939.6MYOG, MYOD1
14skeletal muscle fiber developmentGO:00487419.5MYOD1, MYOG
15cellular response to estradiol stimulusGO:00713929.4MYOG, MYOD1
16positive regulation of muscle cell differentiationGO:00511499.0MYOG, MYOD1
17positive regulation of transcription from RNA polymerase II promoterGO:00459447.8CDX1, SMARCB1, SOX9, HEY1, MYOD1, MYOG

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.4SYNM, VIM, GFAP, DES
2E-box bindingGO:00708889.3MYOG, MYOD1
3identical protein bindingGO:00428029.1DES, VIM, COL2A1, S100B
4chromatin DNA bindingGO:00314909.0MYOG, MYOD1
5nuclear hormone receptor bindingGO:00352579.0NCOA2, MYOD1
6protein bindingGO:00055156.1HEY1, SOX9, NUP107, SMARCB1, DES, VIM

Products for genes affiliated with Mesenchymal Chondrosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Mesenchymal Chondrosarcoma

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet