MCID: MSB002
MIFTS: 50

Mesoblastic Nephroma malady

Nephrological diseases, Cancer diseases, Rare diseases categories

Summaries for Mesoblastic Nephroma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by... more...

MalaCards: Mesoblastic Nephroma, also known as congenital mesoblastic nephroma, is related to congenital mesoblastic nephroma and fibrosarcoma. An important gene associated with Mesoblastic Nephroma is CTCF (CCCTC-binding factor (zinc finger protein)), and among its related pathways is Transcriptional misregulation in cancer. The compounds 2-methoxyethanol and k252a have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Mesoblastic Nephroma

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11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

mesoblastic nephroma 11
congenital mesoblastic nephroma 63
nephroma mesoblastic 46


Related Diseases for Mesoblastic Nephroma

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18GeneCards, 19GeneDecks
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Diseases in the Adult Mesoblastic Nephroma family:

Congenital Mesoblastic Nephroma mesoblastic nephroma

Diseases related to Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1congenital mesoblastic nephroma32.0ETV6, SMARCB1, SSX2B, NTRK3
2fibrosarcoma30.9NTRK3, ETV6, MDM2, VIM
3clear cell sarcoma30.9IGF2, WT1
4wilms tumor30.9IGF2, SMARCB1, KMT2A, CTCF, VIM, REN
5congenital fibrosarcoma30.8ETV6
6nephroblastoma30.7LATS1, WT1
7sarcoma30.7SMARCB1, IGF2, TFE3, WT1, VIM, ETV6
8metanephric adenoma30.5WT1
9hemihypertrophy30.5WT1, IGF2
10beckwith-wiedemann syndrome30.5IGF2, WT1, CTCF
11cellular congenital mesoblastic nephroma10.8
12adult mesoblastic nephroma10.7
13hypercalcemia10.6
14polyhydramnios10.6
15classic congenital mesoblastic nephroma10.5
16hypertension10.5
17neuroblastoma10.5
18hydrops fetalis10.5
19nephrocalcinosis10.4
20renal hypertension10.4
21perinephritis10.2
22hypertrophic pyloric stenosis10.2
23paraganglioma10.2
24adenoma10.2
25disseminated intravascular coagulation10.2
26hepatitis10.2
27leiomyoma10.2
28oligohydramnios10.2
29pyloric stenosis10.2
30renal cell carcinoma10.2
31neurilemmoma10.1SMARCB1
32giant cell glioblastoma10.1MDM2
33alveolar soft part sarcoma10.1TFE3
34embryonal rhabdomyosarcoma10.1IGF2, WT1
35silver-russell syndrome10.1IGF2, CTCF
36acute myelomonocytic leukemia10.1KMT2A, ETV6
37alveolar rhabdomyosarcoma10.1WT1, MDM2
38phyllode tumor10.1IGF2, VIM
39childhood kidney neoplasm10.1WT1, LATS1
40adenomatoid tumor10.1VIM, WT1
41sex cord-gonadal stromal tumor10.1WT1, VIM
42chondrosarcoma10.1MDM2, VIM
43epithelioid sarcoma10.1SMARCB1, VIM
44smooth muscle tumor10.1VIM, IGF2
45spindle cell sarcoma10.1NTRK3, VIM
46abrikosov's tumor10.1WT1, VIM
47acute myeloid leukemia, adult10.1WT1, NTRK3, KMT2A
48malignant peripheral nerve sheath tumor10.1VIM, MDM2
49adrenal adenoma10.1IGF2, REN
50precursor t-cell acute lymphoblastic leukemia10.1KMT2A, WT1, ETV6

Graphical network of the top 20 diseases related to Mesoblastic Nephroma:



Diseases related to mesoblastic nephroma

Symptoms for Mesoblastic Nephroma

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Drugs & Therapeutics for Mesoblastic Nephroma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Mesoblastic Nephroma

Drug clinical trials:

Search ClinicalTrials for Mesoblastic Nephroma

Search NIH Clinical Center for Mesoblastic Nephroma

Search CenterWatch for Mesoblastic Nephroma

Genetic Tests for Mesoblastic Nephroma

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Anatomical Context for Mesoblastic Nephroma

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34MalaCards
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MalaCards organs/tissues related to Mesoblastic Nephroma:

34
Kidney, Brain, Liver, Bone, Lung, Testes, Heart

Animal Models for Mesoblastic Nephroma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mesoblastic Nephroma:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8IGF2, SMARCB1, KMT2A, MDM2, WT1
2MP:00053678.6IGF2, KMT2A, REN, MDM2, WT1
3MP:00053918.5NTRK3, VIM, SMARCB1, IGF2, TFE3
4MP:00020068.3SMARCB1, LATS1, KMT2A, ETV6, MDM2
5MP:00053828.2MDM2, MEOX1, KMT2A, IGF2, TFE3
6MP:00053698.0THBS4, IGF2, KMT2A, VIM, REN, MEOX1
7MP:00053898.0IGF2, SMARCB1, LATS1, KMT2A, VIM, REN
8MP:00053807.8IGF2, SMARCB1, KMT2A, VIM, ETV6, MEOX1
9MP:00028737.6TFE3, ETV6, REN, MEOX1, NTRK3, MDM2
10MP:00030127.6IGF2, LATS1, KMT2A, ETV6, MEOX1, NTRK3
11MP:00036317.4IGF2, SMARCB1, LATS1, KMT2A, VIM, REN
12MP:00053847.4IGF2, SMARCB1, LATS1, KMT2A, VIM, ETV6
13MP:00107717.2TFE3, IGF2, LATS1, KMT2A, ETV6, MEOX1
14MP:00053766.9THBS4, IGF2, SMARCB1, LATS1, KMT2A, VIM
15MP:00053876.9TFE3, IGF2, SMARCB1, KMT2A, VIM, ETV6
16MP:00053856.7THBS4, IGF2, SMARCB1, LATS1, KMT2A, VIM
17MP:00053976.5TFE3, THBS4, IGF2, SMARCB1, KMT2A, VIM
18MP:00107685.6KMT2A, LATS1, SMARCB1, IGF2, TFE3, VIM
19MP:00053785.5WT1, TFE3, THBS4, IGF2, SMARCB1, LATS1

Publications for Mesoblastic Nephroma

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53PubMed
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Articles related to Mesoblastic Nephroma:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. (22236896)
2012
2
Cellular congenital mesoblastic nephroma: case report. (21541470)
2011
3
Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (20455206)
2010
4
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
5
Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. (19629465)
2009
6
Unusual morphology in mesoblastic nephroma. (18989680)
2009
7
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report. (18485932)
2008
8
WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. (19011477)
2008
9
Congenital mesoblastic nephroma presenting with massive hematuria and hemorrhagic shock: report of one case. (17078466)
2006
10
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
11
Gene expression profiling of mesoblastic nephroma and Wilms tumors--comparison and clinical implications. (15302496)
2004
12
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
13
Use of sarcoma-based chemotherapy in a case of congenital mesoblastic nephroma with liver metastases. (12809924)
2003
14
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)
2001
15
Cytogenetic and molecular characterization of a congenital mesoblastic nephroma. (11441343)
2001
16
Diagnosis of a fetal mesoblastic nephroma by 3D-ultrasound. (11005125)
2000
17
Hyperreninemia and congenital mesoblastic nephroma: case report and review of the literature. (10792110)
2000
18
Mesoblastic nephroma: prenatal ultrasonographic and MRI features. (10755750)
2000
19
Congenital mesoblastic nephroma: A rare cause of perinatal anemia. (9931540)
1999
20
Congenital mesoblastic nephroma (CMN) with an unusual immunohistochemical feature. (10371751)
1999
21
Congenital mesoblastic nephroma. (9361489)
1997
22
Classical congenital mesoblastic nephroma in an adult: a case report on an Ethiopian. (10214440)
1997
23
Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. (9302166)
1997
24
A novel reciprocal translocation (14;15)(q11;q24) in a congenital mesoblastic nephroma. (8630977)
1996
25
Ultrastructure of cellular congenital mesoblastic nephroma. (8883325)
1996
26
Congenital mesoblastic nephroma associated with focal and segmental sclerosis. (8587629)
1995
27
Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma. (7923083)
1994
28
Chromosome aberrations in mesoblastic nephroma. (8395771)
1993
29
Congenital mesoblastic nephroma: an immunohistochemical and lectin study. (8387953)
1993
30
Nucleolar organizer regions in congenital mesoblastic nephroma. (1333074)
1992
31
Congenital mesoblastic nephroma, hemorrhagic shock, and disseminated intravascular coagulation in a newborn infant. (1851423)
1991
32
Congenital mesoblastic nephroma occurring in a solitary kidney. (2157574)
1990
33
Congenital mesoblastic nephroma: report of a case. (2556493)
1989
34
Identification of an acidic fibroblast growth factor-like activity in a mesoblastic nephroma. (2538677)
1989
35
Prenatal diagnosis of congenital mesoblastic nephroma in association with polyhydramnios. (2845674)
1988
36
Prenatal diagnosis of fetal renal mesoblastic nephroma. (3006495)
1986
37
Congenital mesoblastic nephroma study of 7 cases--report of a case of atypical mesoblastic nephroma. (2820867)
1986
38
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
39
Calcification and ossification in a congenital mesoblastic nephroma. (3000046)
1985
40
Mesoblastic nephromas: a study of 29 tumours from the SIOP nephroblastoma file. (2995226)
1985
41
Prenatal sonographic detection of congenital mesoblastic nephroma in a monozygotic twin pregnancy. (6317883)
1983
42
Cystic mesoblastic nephroma. (6277070)
1982
43
Therapy and outcome in 51 children with mesoblastic nephroma: a report of the National Wilms' Tumor Study. (6298397)
1982
44
Mesoblastic nephroma: radiologic-pathologic correlation of 20 cases. (6257095)
1981
45
Congenital mesoblastic nephroma presenting with primary reninism. (221639)
1979
46
Congenital mesoblastic nephroma. (189563)
1976
47
The management of benign renal tumors of infancy. Case report of a congenital mesoblastic nephroma (leiomyomatous hamartoma). (168170)
1975
48
Congenital mesoblastic nephroma of infancy. (164787)
1975
49
Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior. (4357122)
1973
50
Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumor. (4378178)
1967

Variations for Mesoblastic Nephroma

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Expression for genes affiliated with Mesoblastic Nephroma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesoblastic Nephroma

Search GEO for disease gene expression data for Mesoblastic Nephroma.

Pathways for genes affiliated with Mesoblastic Nephroma

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51PathCards, 31KEGG
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Pathways related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
17.5WT1, MDM2, SSX2B, ETV6, KMT2A, TFE3

Compounds for genes affiliated with Mesoblastic Nephroma

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46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4610.2VIM, IGF2
2k252a4610.0NTRK3, VIM
3b 7234610.0VIM, WT1
4gefitinib46 52 1211.9IGF2, VIM, MDM2
5hydrocortisone46 3 62 1212.9REN, VIM, IGF2
6valine469.8MDM2, VIM, IGF2
7chloramphenicol46 3 52 1212.7WT1, VIM, IGF2
8forskolin46 52 1211.7WT1, REN, VIM, IGF2
9p00001469.7KMT2A, MDM2
10paraffin469.7IGF2, VIM, MDM2, WT1
11estradiol46 25 1211.6IGF2, VIM, REN, MDM2
12butyrate469.6WT1, VIM, IGF2
13creatinine469.6WT1, REN, VIM, IGF2
14calcitriol46 62 25 1212.6IGF2, KMT2A, REN, WT1
15steroid469.6IGF2, REN, MDM2, WT1, CTCF
16progesterone46 30 62 25 1213.5IGF2, VIM, MDM2, WT1
17cycloheximide469.5IGF2, VIM, NTRK3, MDM2
18vincristine46 52 1211.5KMT2A, VIM, MDM2, WT1
19doxorubicin46 52 1211.4KMT2A, VIM, MDM2, WT1
20actinomycin d469.4IGF2, KMT2A, VIM, MDM2
21testosterone46 62 25 1212.4IGF2, VIM, NTRK3, MDM2, WT1
22prednisolone46 30 1211.4IGF2, KMT2A, ETV6
23agar469.3IGF2, VIM, ETV6, MDM2
24indomethacin46 30 62 1212.3IGF2, VIM, REN
25zinc46 2510.3CTCF, WT1, MDM2, KMT2A, IGF2
265-aza-2deoxycytidine469.2IGF2, KMT2A, VIM, MDM2, CTCF
27aspartate469.2KMT2A, VIM, NTRK3, MDM2
28etoposide46 52 62 1212.2IGF2, KMT2A, VIM, MDM2, WT1
29dexamethasone46 52 30 1212.2MDM2, REN, VIM, IGF2
30oligonucleotide469.2WT1, MDM2, VIM, KMT2A, IGF2
31imatinib46 52 1211.2IGF2, ETV6, NTRK3, MDM2, WT1
32estrogen469.1IGF2, KMT2A, VIM, MDM2, WT1
33arginine468.9IGF2, KMT2A, VIM, REN, MDM2, WT1
34threonine468.9WT1, MDM2, NTRK3, KMT2A, LATS1
35retinoic acid46 259.6IGF2, KMT2A, VIM, ETV6, NTRK3, WT1
36vegf468.5IGF2, VIM, ETV6, REN, NTRK3, MDM2
37tyrosine468.2THBS4, IGF2, KMT2A, ETV6, NTRK3, MDM2
38serine468.1THBS4, IGF2, LATS1, KMT2A, VIM, MDM2
39proline468.0WT1, MDM2, NTRK3, VIM, KMT2A, THBS4

GO Terms for genes affiliated with Mesoblastic Nephroma

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17Gene Ontology
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Cellular components related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.2SMARCB1, KMT2A, SSX2B, MEOX1, MDM2, WT1
2nucleolusGO:0057307.2CTCF, TFE3, SMARCB1, KMT2A, ETV6, MDM2

Biological processes related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of gene expression by genetic imprintingGO:00634910.0CTCF, IGF2
2positive regulation of gene expressionGO:0106289.5NTRK3, MDM2, CTCF
3hormone-mediated signaling pathwayGO:0097559.4REN, LATS1
4regulation of transcription from RNA polymerase II promoterGO:0063579.3WT1, ETV6, SMARCB1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.0WT1, MEOX1, KMT2A, SMARCB1, IGF2, TFE3

Molecular functions related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.9IGF2, REN
2scaffold protein bindingGO:0971109.8MDM2, VIM
3p53 bindingGO:0020399.6MDM2, NTRK3, SMARCB1
4transcription regulatory region DNA bindingGO:0442128.8TFE3, KMT2A, WT1, CTCF
5sequence-specific DNA bindingGO:0435658.7CTCF, WT1, MEOX1, ETV6
6sequence-specific DNA binding transcription factor activityGO:0037007.7TFE3, KMT2A, ETV6, MEOX1, WT1, CTCF
7protein bindingGO:0055156.5CTCF, THBS4, IGF2, SMARCB1, LATS1, KMT2A

Products for genes affiliated with Mesoblastic Nephroma

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  • Antibodies
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Sources for Mesoblastic Nephroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet