MCID: MSB002
MIFTS: 42

Mesoblastic Nephroma malady

Nephrological category

Summaries for Mesoblastic Nephroma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by... more...

MalaCards: Mesoblastic Nephroma, also known as congenital mesoblastic nephroma, is related to wilms tumor and congenital fibrosarcoma. An important gene associated with Mesoblastic Nephroma is WT1 (Wilms tumor 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds 2-methoxyethanol and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related mouse phenotypes are embryogenesis and muscle.

Aliases & Classifications for Mesoblastic Nephroma

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

mesoblastic nephroma 10
congenital mesoblastic nephroma 61
nephroma mesoblastic 45


Related Diseases for Mesoblastic Nephroma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the adult mesoblastic nephroma family:

congenital mesoblastic nephroma mesoblastic nephroma

Diseases related to Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.9VIM, WT1, CTCF, IGF2, REN, KMT2A
2congenital fibrosarcoma30.8ETV6
3clear cell sarcoma30.7IGF2, WT1
4metanephric adenoma30.3WT1
5adenoma30.3REN, IGF2
6hemihypertrophy30.3IGF2, WT1
7beckwith-wiedemann syndrome30.3IGF2, CTCF, WT1
8adult mesoblastic nephroma10.9
9cellular congenital mesoblastic nephroma10.9
10cystic nephroma10.7
11hypercalcemia10.7
12classic congenital mesoblastic nephroma10.6
13polyhydramnios10.6
14hydrops fetalis10.5
15nephrocalcinosis10.4
16n syndrome10.4
17kidney clear cell sarcoma10.4
18clear cell adenoma10.2
19renal wilms' tumor10.2
20paraganglioma10.2
21hypertrophic pyloric stenosis10.2
22benign mesothelioma10.0WT1
23uterine sarcoma10.0MDM2
24liver cirrhosis10.0REN
25atypical teratoid rhabdoid tumor10.0SMARCB1
26hyperandrogenism10.0IGF2
27giant cell glioblastoma10.0MDM2
28wagr syndrome10.0WT1
29chordoma10.0VIM
30rhabdoid cancer10.0SMARCB1
31pancreatic cancer10.0NTRK3
32perivascular epithelioid cell tumor10.0TFE3
33neurilemmoma10.0SMARCB1
34angiosarcoma10.0VIM
35glioblastoma multiforme10.0MDM2, SMARCB1
36chondrosarcoma10.0MDM2, VIM
37malignant mesothelioma10.0WT1, VIM
38ovarian cancer10.0IGF2, MDM2
39ependymoma10.0MDM2, VIM
40smooth muscle tumor10.0VIM, IGF2
41primary hyperoxaluria10.0REN, WT1
42phyllode tumor10.0IGF2, VIM
43gastrointestinal stromal tumor10.0NTRK3, VIM
44alveolar rhabdomyosarcoma10.0WT1, MDM2
45spindle cell sarcoma10.0VIM, NTRK3
46oxyphilic adenoma10.0TFE3
47epithelioid sarcoma10.0VIM, SMARCB1
48sex cord-gonadal stromal tumor10.0VIM, WT1
49alveolar soft part sarcoma10.0VIM, TFE3
50medulloblastoma10.0SMARCB1, IGF2, NTRK3

Graphical network of the top 20 diseases related to Mesoblastic Nephroma:



Diseases related to mesoblastic nephroma

Clinical Features for Mesoblastic Nephroma

Drugs & Therapeutics for Mesoblastic Nephroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mesoblastic Nephroma

Drug clinical trials:

Search ClinicalTrials for Mesoblastic Nephroma

Search NIH Clinical Center for Mesoblastic Nephroma

Search CenterWatch for Mesoblastic Nephroma

Genetic Tests for Mesoblastic Nephroma

Anatomical Context for Mesoblastic Nephroma

Sources:
33MalaCards
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MalaCards organs/tissues related to Mesoblastic Nephroma:

33
Brain, Heart, Kidney, Liver, Lung, T cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Mesoblastic Nephroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mesoblastic Nephroma

Sources:
51PubMed
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Articles related to Mesoblastic Nephroma:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Congenital mesoblastic nephroma: A rare cause of recurrent hematuria beyond infancy. (23960358)
2013
2
Cellular mesoblastic nephroma with liver metastasis in a neonate: prenatal and postnatal diffusion-weighted MR imaging. (23483232)
2013
3
AIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma. (22236896)
2012
4
Pathology in practice. Congenital mesoblastic nephroma. (21961632)
2011
5
Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology. (21075369)
2011
6
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update. (20845287)
2010
7
Imaging of congenital mesoblastic nephroma with pathological correlation. (19629463)
2009
8
Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. (19629465)
2009
9
Pamidronate therapy for hypercalcemia and congenital mesoblastic nephroma: a case report. (20062638)
2009
10
Cellular mesoblastic nephroma in an infant: report of the cytologic diagnosis of a rare paediatric renal tumor. (19217046)
2009
11
Congenital mesoblastic nephroma presenting with massive hematuria and hemorrhagic shock: report of one case. (17078466)
2006
12
Mesoblastic nephroma: a case report of prenatal detection by MR imaging. (16785727)
2006
13
Congenital mesoblastic nephroma presenting with neonatal hypertension. (15858607)
2005
14
Pathologic quiz case: renal mass in a 3-week-old infant. Congenital mesoblastic nephroma, mixed type. (15270602)
2004
15
Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. (14634980)
2003
16
Unusual mesoblastic nephroma in a young child. (12497244)
2003
17
Prenatal diagnosis of congenital mesoblastic nephroma in 2 siblings. (12901411)
2003
18
Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy. (12218597)
2002
19
Perinephric cystic mesoblastic nephroma complicated by hepatic metastases: a case report. (12389112)
2002
20
Congenital mesoblastic nephroma associated with polyhydramnios and hypercalcemia. (11956858)
2002
21
Cytogenetic and molecular characterization of a congenital mesoblastic nephroma. (11441343)
2001
22
Adult mesoblastic nephroma. (10707372)
2000
23
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. (10658907)
2000
24
Mesoblastic nephroma in adulthood: a case report. (10466454)
1999
25
Congenital mesoblastic nephroma and trisomy 11. (9595049)
1998
26
Insulin-like growth factor II gene expression by congenital mesoblastic nephroma. (8634785)
1995
27
Mesoblastic nephroma: a case report. (7796365)
1995
28
Presence or absence of trisomy 11 is correlated with histologic subtype in congenital mesoblastic nephroma. (7923083)
1994
29
Cytologic findings in congenital mesoblastic nephroma. A case report. (8147217)
1994
30
Chromosome aberrations in mesoblastic nephroma. (8395771)
1993
31
Congenital mesoblastic nephroma: cytogenetic comparison to leiomyoma. (8396768)
1993
32
Mesoblastic nephroma. (8108307)
1993
33
A further diagnostic test in neonatal/infant solid renal mass: two cases of mesoblastic nephroma showing uptake of Tc99mDMSA. (8388326)
1993
34
Renal transplacental carcinogenicity of 3,3-dimethyl-1-phenyltriazene in rats: relationship of renal mesenchymal tumor to congenital mesoblastic nephroma and intralobar nephrogenic rests. (1338235)
1992
35
Congenital cystic mesoblastic nephroma: a rare cystic renal tumour of childhood. Case report. (1332189)
1992
36
Congenital mesoblastic nephroma, hemorrhagic shock, and disseminated intravascular coagulation in a newborn infant. (1851423)
1991
37
Mesoblastic nephroma. (2152959)
1990
38
Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: II. Comparative pathology. (2546132)
1989
39
Congenital mesoblastic nephroma in a dog: a benign variant of nephroblastoma. (2548317)
1989
40
Atypical congenital mesoblastic nephroma. Report of a case with karyotypic and flow cytometric analysis. (2549909)
1989
41
Congenital mesoblastic nephroma: a clinicoradiologic study of 17 cases representing the pathologic spectrum of the disease. (3037055)
1987
42
Prenatal diagnosis of a congenital mesoblastic nephroma. A case report. (3012082)
1986
43
Congenital mesoblastic nephroma of infancy associated with hypercalcemia. (3007779)
1986
44
Prenatal appearance of a mesoblastic nephroma associated with polyhydramnios. (2997303)
1985
45
Congenital mesoblastic nephroma: prenatal ultrasonic findings and surgical excision in a very-low-birth-weight infant. (2997304)
1985
46
Cellular congenital mesoblastic nephroma in a newborn. (6097889)
1984
47
Mesoblastic nephroma in an adult patient: recurrence 21 years after removal of the primary lesion. (6277452)
1982
48
Mesoblastic nephroma: radiologic-pathologic correlation of 20 cases. (6257095)
1981
49
Congenital mesoblastic nephroma: relationship to other renal tumors of infancy. (6270389)
1981
50
Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumor. (4378178)
1967

Genetic Variations for Mesoblastic Nephroma

Expression for genes affiliated with Mesoblastic Nephroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mesoblastic Nephroma

Search GEO for disease gene expression data for Mesoblastic Nephroma.

Pathways for genes affiliated with Mesoblastic Nephroma

Sources:
30KEGG
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Pathways related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.0KMT2A, ETV6, SSX2B, MDM2, TFE3, WT1

Compounds for genes affiliated with Mesoblastic Nephroma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4510.2VIM, IGF2
2gefitinib45 50 1112.0VIM, MDM2, IGF2
3hydrocortisone45 2 60 1112.8VIM, IGF2, REN
4steroid459.6WT1, CTCF, MDM2, REN
5calcitriol45 60 11 2412.6KMT2A, REN, IGF2, WT1
6vincristine45 50 1111.5VIM, WT1, MDM2, KMT2A
7estradiol45 11 2411.5REN, IGF2, MDM2, VIM
8agar459.5VIM, MDM2, IGF2, ETV6
9paraffin459.5VIM, WT1, MDM2, IGF2
10testosterone45 60 11 2412.5IGF2, NTRK3, MDM2, WT1, VIM
11doxorubicin45 50 1111.4KMT2A, MDM2, WT1, VIM
12actinomycin d459.4VIM, MDM2, IGF2, KMT2A
13imatinib45 50 1111.4WT1, MDM2, NTRK3, IGF2, ETV6
14prednisolone45 29 1111.4KMT2A, ETV6, IGF2
15etoposide45 50 60 1112.3VIM, WT1, MDM2, IGF2, KMT2A
16oligonucleotide459.2KMT2A, IGF2, MDM2, WT1, VIM
17forskolin45 50 1111.2VIM, WT1, IGF2, REN
185-aza-2deoxycytidine459.1VIM, CTCF, MDM2, IGF2, KMT2A
19arginine459.0VIM, WT1, MDM2, IGF2, REN, KMT2A
20vegf458.8VIM, WT1, MDM2, NTRK3, IGF2, ETV6
21zinc45 249.7KMT2A, IGF2, MDM2, CTCF, WT1
22retinoic acid45 249.7KMT2A, ETV6, IGF2, NTRK3, WT1, VIM
23tyrosine458.4WT1, MDM2, NTRK3, IGF2, ETV6, KMT2A
24threonine458.4LATS1, KMT2A, NTRK3, MDM2, WT1
25proline458.3THBS4, KMT2A, NTRK3, MDM2, TFE3, WT1
26serine457.7VIM, WT1, CTCF, MDM2, IGF2, KMT2A

GO Terms for genes affiliated with Mesoblastic Nephroma

Sources:
16Gene Ontology
See all sources

Biological processes related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glomerular visceral epithelial cell differentiationGO:07211210.2CD24, WT1
2regulation of MAPK cascadeGO:04340810.1REN, CD24
3positive regulation of activated T cell proliferationGO:0421049.9IGF2, CD24
4regulation of gene expression by genetic imprintingGO:0063499.8IGF2, CTCF
5positive regulation of gene expressionGO:0106289.5NTRK3, MDM2, CTCF
6hormone-mediated signaling pathwayGO:0097559.1REN, LATS1

Molecular functions related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0REN, IGF2
2p53 bindingGO:0020399.6SMARCB1, NTRK3, MDM2
3transcription regulatory region DNA bindingGO:0442128.7WT1, CTCF, TFE3, KMT2A
4sequence-specific DNA binding transcription factor activityGO:0037007.5WT1, CTCF, TFE3, MEOX1, ETV6, KMT2A
5protein bindingGO:0055155.6SMARCB1, VIM, WT1, CTCF, MDM2, PRUNE

Products for genes affiliated with Mesoblastic Nephroma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mesoblastic Nephroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet