MCID: MSB002
MIFTS: 34

Mesoblastic Nephroma malady

Nephrological diseases category

Summaries for Mesoblastic Nephroma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by... more...

MalaCards: Mesoblastic Nephroma, also known as congenital mesoblastic nephroma, is related to congenital mesoblastic nephroma and fibrosarcoma. An important gene associated with Mesoblastic Nephroma is WT1 (Wilms tumor 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds 2-methoxyethanol and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are embryogenesis and muscle.

Aliases & Classifications for Mesoblastic Nephroma

About this section
Sources:
10DISEASES, 44Novoseek, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

mesoblastic nephroma 10
congenital mesoblastic nephroma 60
nephroma mesoblastic 44


Related Diseases for Mesoblastic Nephroma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Adult Mesoblastic Nephroma family:

Congenital Mesoblastic Nephroma mesoblastic nephroma

Diseases related to Mesoblastic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1congenital mesoblastic nephroma31.9NTRK3, SSX2B, ETV6, SMARCB1
2fibrosarcoma30.8VIM, MDM2, NTRK3, ETV6
3congenital fibrosarcoma30.8ETV6
4sarcoma30.7VIM, WT1, TFE3, MDM2, IGF2, ETV6
5clear cell sarcoma30.6IGF2, WT1
6nephroblastoma30.5LATS1, WT1
7metanephric adenoma30.3WT1
8adenoma30.2REN, IGF2
9beckwith-wiedemann syndrome30.2IGF2, CTCF, WT1
10adult mesoblastic nephroma10.8
11cellular congenital mesoblastic nephroma10.8
12cystic nephroma10.7
13hypercalcemia10.6
14classic congenital mesoblastic nephroma10.6
15polyhydramnios10.5
16hypertension10.5
17neuroblastoma10.4
18nephrocalcinosis10.3
19kidney clear cell sarcoma10.3
20kidney sarcoma10.3
21renal hypertension10.3
22clear cell adenoma10.2
23renal wilms' tumor10.2
24perinephritis10.2
25fibrosarcoma of bone10.2
26paraganglioma10.2
27hypertrophic pyloric stenosis10.2
28hepatitis a10.2
29disseminated intravascular coagulation10.2
30hepatitis10.2
31leiomyoma10.2
32liver sarcoma10.2
33oligohydramnios10.2
34pediatric fibrosarcoma10.2
35pyloric stenosis10.2
36renal cell carcinoma10.2
37benign mesothelioma10.0WT1
38uterine sarcoma10.0MDM2
39liver cirrhosis10.0REN
40atypical teratoid rhabdoid tumor10.0SMARCB1
41hyperandrogenism10.0IGF2
42giant cell glioblastoma10.0MDM2
43wagr syndrome10.0WT1
44chordoma10.0VIM
45rhabdoid cancer10.0SMARCB1
46pancreatic cancer10.0NTRK3
47perivascular epithelioid cell tumor10.0TFE3
48neurilemmoma10.0SMARCB1
49angiosarcoma10.0VIM
50glioblastoma multiforme10.0MDM2, SMARCB1

Graphical network of the top 20 diseases related to Mesoblastic Nephroma:



Diseases related to mesoblastic nephroma

Clinical Features for Mesoblastic Nephroma

About this section

Drugs & Therapeutics for Mesoblastic Nephroma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mesoblastic Nephroma

Drug clinical trials:

Search ClinicalTrials for Mesoblastic Nephroma

Search NIH Clinical Center for Mesoblastic Nephroma

Search CenterWatch for Mesoblastic Nephroma

Genetic Tests for Mesoblastic Nephroma

About this section

Anatomical Context for Mesoblastic Nephroma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mesoblastic Nephroma:

32
Kidney

Animal Models for Mesoblastic Nephroma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mesoblastic Nephroma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.4MEOX1, KMT2A, VIM
2MP:00053698.6WT1, MDM2, MEOX1, IGF2, REN, THBS4
3MP:00036318.4NTRK3, KMT2A, LATS1, MEOX1
4MP:00053897.6WT1, MDM2, IGF2, CD24, REN, KMT2A
5MP:00053847.5SMARCB1, KMT2A, CD24, ETV6, IGF2, MDM2
6MP:00030127.5LATS1, KMT2A, ETV6, NTRK3, WT1, MDM2
7MP:00053767.2SMARCB1, LATS1, THBS4, KMT2A, REN, ETV6
8MP:00107716.9KMT2A, LATS1, ETV6, IGF2, MEOX1, MDM2
9MP:00053976.8CTCF, TFE3, MDM2, IGF2, ETV6, SMARCB1
10MP:00053876.8VIM, WT1, CTCF, TFE3, MDM2, IGF2
11MP:00053856.8LATS1, THBS4, KMT2A, VIM, REN, ETV6
12MP:00053785.8KMT2A, THBS4, REN, ETV6, IGF2, NTRK3
13MP:00107685.6CTCF, SMARCB1, LATS1, KMT2A, REN, ETV6

Publications for Mesoblastic Nephroma

About this section

Genetic Variations for Mesoblastic Nephroma

About this section

Expression for genes affiliated with Mesoblastic Nephroma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mesoblastic Nephroma

Search GEO for disease gene expression data for Mesoblastic Nephroma.

Pathways for genes affiliated with Mesoblastic Nephroma

About this section
Sources:
29KEGG
See all sources

Pathways related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.0KMT2A, ETV6, SSX2B, MDM2, TFE3, WT1

Compounds for genes affiliated with Mesoblastic Nephroma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
See all sources

Compounds related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4410.2VIM, IGF2
2gefitinib44 49 1112.0MDM2, VIM, IGF2
3hydrocortisone44 2 59 1112.8VIM, IGF2, REN
4steroid449.6WT1, REN, MDM2, CTCF
5calcitriol44 59 11 2412.6WT1, KMT2A, REN, IGF2
6vincristine44 49 1111.5VIM, WT1, MDM2, KMT2A
7estradiol44 11 2411.5VIM, MDM2, REN, IGF2
8agar449.5VIM, MDM2, IGF2, ETV6
9paraffin449.5VIM, IGF2, WT1, MDM2
10testosterone44 59 11 2412.5VIM, WT1, MDM2, NTRK3, IGF2
11doxorubicin44 49 1111.4WT1, VIM, MDM2, KMT2A
12actinomycin d449.4VIM, KMT2A, IGF2, MDM2
13imatinib44 49 1111.4WT1, MDM2, NTRK3, IGF2, ETV6
14prednisolone44 28 1111.4IGF2, KMT2A, ETV6
15etoposide44 49 59 1112.3KMT2A, IGF2, MDM2, WT1, VIM
16oligonucleotide449.2WT1, MDM2, IGF2, VIM, KMT2A
17forskolin44 49 1111.2REN, VIM, IGF2, WT1
185-aza-2deoxycytidine449.1VIM, IGF2, MDM2, KMT2A, CTCF
19arginine449.0KMT2A, REN, IGF2, MDM2, WT1, VIM
20vegf448.8MDM2, NTRK3, REN, ETV6, IGF2, VIM
21zinc44 249.7KMT2A, IGF2, MDM2, CTCF, WT1
22retinoic acid44 249.7NTRK3, VIM, WT1, IGF2, ETV6, KMT2A
23tyrosine448.4MDM2, WT1, NTRK3, KMT2A, IGF2, ETV6
24threonine448.4MDM2, LATS1, NTRK3, KMT2A, WT1
25proline448.3VIM, TFE3, MDM2, WT1, THBS4, NTRK3
26serine447.7CTCF, MDM2, IGF2, KMT2A, THBS4, LATS1

GO Terms for genes affiliated with Mesoblastic Nephroma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glomerular visceral epithelial cell differentiationGO:07211210.2WT1, CD24
2regulation of MAPK cascadeGO:04340810.1CD24, REN
3positive regulation of activated T cell proliferationGO:0421049.9CD24, IGF2
4regulation of gene expression by genetic imprintingGO:0063499.8IGF2, CTCF
5positive regulation of gene expressionGO:0106289.5MDM2, NTRK3, CTCF
6hormone-mediated signaling pathwayGO:0097559.1REN, LATS1

Molecular functions related to Mesoblastic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0REN, IGF2
2p53 bindingGO:0020399.6NTRK3, MDM2, SMARCB1
3transcription regulatory region DNA bindingGO:0442128.7KMT2A, TFE3, CTCF, WT1
4sequence-specific DNA binding transcription factor activityGO:0037007.5CTCF, TFE3, WT1, ETV6, KMT2A, MEOX1
5protein bindingGO:0055155.6KMT2A, ETV6, THBS4, LATS1, SMARCB1, IGF2

Products for genes affiliated with Mesoblastic Nephroma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mesoblastic Nephroma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet