MCID: MTB004
MIFTS: 48

Metabolic Acidosis malady

Metabolic diseases category

Summaries for Metabolic Acidosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when... more...

MalaCards: Metabolic Acidosis is related to lactic acidosis and renal tubular acidosis. An important gene associated with Metabolic Acidosis is FBP1 (fructose-1,6-bisphosphatase 1), and among its related pathways are Glutathione synthesis and recycling and Glycolysis and gluconeogenesis (short map). The compounds furosemide and hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 A lactic acidosis that has material basis in high levels of acid.

Aliases & Classifications for Metabolic Acidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

metabolic acidosis 8 10 44 60


External Ids:

Disease Ontology8 DOID:0050758

Related Diseases for Metabolic Acidosis

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17GeneCards, 18GeneDecks
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Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1lactic acidosis30.5OGDH
2renal tubular acidosis30.5ATP6V1B1, CA2
3hypertension30.2SCNN1G, WNK4, ALB
4glutathione synthetase deficiency30.2GSS, OPLAH
5diabetes mellitus30.2ALB, SLC9A3, GLS2, FBP1, PDP1
6hypokalemia30.1AQP2, SLC9A3, ATP6AP1
7hemolytic anemia30.1OPLAH, FBP1, GSS
8hypoglycemia29.9HMGCL, GLS2, MLYCD, FBP1
9deficiency anemia29.9CA2, ALB
10kidney disease10.5
11diabetic ketoacidosis10.4
12diarrhea10.3
13asthma10.3
14hyperglycemia10.2
15uremia10.2
16hypophosphatemia10.2
17cerebritis10.2
18peritonitis10.2
19status epilepticus10.1
20hyperphosphatemia10.1
21neuronitis10.1
22type 1 diabetes mellitus10.1
23duodenitis10.1
24beriberi10.1
25hepatitis10.1
26hypothyroidism10.1
27thyroiditis10.1
28hmg coa lyase deficiency10.1
29renal tubular acidosis with deafness10.1
30glutaric acidemia iic10.1
31pseudohypoaldosteronism10.0KLHL3, SCNN1G, WNK4
32galactosemia10.0ALB
33maple syrup urine disease10.0HMGCL
34liddle syndrome10.0WNK4, SCNN1G, KLHL3
35nephrocalcinosis10.0ATP6V1B1, CA2
36cystic fibrosis10.0AQP2, ALB, SLC9A3, ATP6AP1, PDP1, CA2
37tuberculosis10.0ALB, AKR1A1, PDP1, OGDH
38essential hypertension10.0WNK4, ALB, AQP2
39liver cirrhosis10.0PDP1, AKR1A1, ALB, AQP2
40renal tubular acidosis, distal10.0ATP6V1B1, CA2
41pseudohypoaldosteronism type ii10.0WNK4
42primary biliary cirrhosis10.0OGDH
43hepatorenal syndrome10.0ALB
44diabetic nephropathy10.0AQP2, ALB, SLC9A3
45primary hyperoxaluria10.0CA2, SLC9A3, ALB, AQP2
46pasteurellosis10.0PDP1
47burns9.9
48periventricular leukomalacia9.9
49plasmodium malariae malaria9.9
50renal osteodystrophy9.9

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to metabolic acidosis

Clinical Features for Metabolic Acidosis

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Drugs & Therapeutics for Metabolic Acidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Metabolic Acidosis

Drug clinical trials:

Search ClinicalTrials for Metabolic Acidosis

Search NIH Clinical Center for Metabolic Acidosis

Search CenterWatch for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

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Anatomical Context for Metabolic Acidosis

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32MalaCards
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MalaCards organs/tissues related to Metabolic Acidosis:

32
Kidney, Bone, Heart, Liver, Brain, Skeletal muscle, Lung, Thyroid, Colon, Small intestine, Endothelial, Breast, Testes, Cortex

Animal Models for Metabolic Acidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Metabolic Acidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3SCNN1G, AKR1A1, MLYCD, ATP6V1B1, WNK4, SLC9A3
2MP:000536710.0AQP2, CA2, SCNN1G, AKR1A1, ATP6V1B1, WNK4

Publications for Metabolic Acidosis

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50PubMed
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Articles related to Metabolic Acidosis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Evaluation of acid-base status in brain dead donors and the impact of metabolic acidosis on organ retrieval. (24042153)
2013
2
5-Oxoprolinuria as a cause of high anion gap metabolic acidosis. (21988557)
2012
3
Topiramate-induced metabolic acidosis: a case study. (22592431)
2012
4
Problem-based review: A patient with metabolic acidosis. (23364112)
2012
5
Defining metabolic acidosis in patients with septic shock using Stewart approach. (21277142)
2012
6
Severe metabolic acidosis in a newborn with an abnormal newborn screen. (22500046)
2012
7
Metabolic acidosis in healthy mules under general anaesthesia with halothane. (21831054)
2011
8
TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice. (21111026)
2011
9
Metabolic acidosis in septic shock: is the Stewart theory the magic bullet? (21641748)
2011
10
Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion-gap metabolic acidosis. (21794966)
2011
11
Influence of mild metabolic acidosis on cardiac contractility and isoprenaline response in isolated ovine myocardium. (22097981)
2011
12
Continuous venovenous hemodiafiltration in severe metabolic acidosis secondary to ethylene glycol ingestion. (20622722)
2010
13
The cause of metabolic acidosis. (20551926)
2010
14
Hunting down a double gap metabolic acidosis. (20406777)
2010
15
Metabolic acidosis: pathophysiology, diagnosis and management. (20308999)
2010
16
Refractory metabolic acidosis as a complication of high-dose midazolam infusion for pediatric status epilepticus. (19952873)
2009
17
Body out of balance: understanding metabolic acidosis and alkalosis. (19859004)
2009
18
The case. A suicidal woman with delayed high anion gap metabolic acidosis. (19282861)
2009
19
Gene expression profile of duodenal epithelial cells in response to chronic metabolic acidosis. (18979233)
2009
20
Type 1 (distal) renal tubular acidosis in a patient with Type 1 diabetes mellitus--not all cases of metabolic acidosis in Type 1 diabetes mellitus are due to diabetic ketoacidosis. (18199141)
2008
21
Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. (18052757)
2008
22
The importance of never ignoring an unexplained metabolic acidosis. Incarcerated femoral hernia. (18755711)
2008
23
Umbilical cord blood lactate: a valuable tool in the assessment of fetal metabolic acidosis. (18063469)
2008
24
Limitations of ST analysis in clinical practice: three cases of intrapartum metabolic acidosis. (18333954)
2008
25
Unmeasured anions account for most of the metabolic acidosis in patients with hyperlactatemia. (17334550)
2007
26
Correction of chronic metabolic acidosis for chronic kidney disease patients. (17253467)
2007
27
Re: Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. (17957194)
2007
28
Metabolic acidosis in childhood: why, when and how to treat. (17508091)
2007
29
Regulation of renal amino acid transporters during metabolic acidosis. (17003226)
2007
30
Excess casein in the diet is not the unique cause of low-grade metabolic acidosis: role of a deficit in potassium citrate in a rat model. (16407650)
2006
31
Refractory metabolic acidosis in small cell cancer of the lung. (16869054)
2006
32
Acid-base disturbances in the intensive care unit: metabolic acidosis. (17150049)
2006
33
Topical brinzolamide and metabolic acidosis. (16424547)
2006
34
Differentiating the causes of metabolic acidosis in the poisoned patient. (16567224)
2006
35
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. (15983968)
2005
36
Base administration or fluid bolus for preventing morbidity and mortality in preterm infants with metabolic acidosis. (15846651)
2005
37
Successful management of extreme hypernatraemia by haemofiltration in a patient with severe metabolic acidosis and renal failure. (15985507)
2005
38
Metabolic acidosis due to propofol infusion. (15731621)
2005
39
Topiramate induced metabolic acidosis. (15270982)
2004
40
Regulation of aquaporin-2 by metabolic acidosis. (15308467)
2004
41
Effect of chronic renal failure with metabolic acidosis on alanine metabolism in isolated liver cells. (15158294)
2004
42
Persistent non-gastrointestinal metabolic acidosis in pediatric HIV-1 infection. (12646789)
2003
43
Inhibition of glutamine synthetase in the mouse kidney: a novel mechanism of adaptation to metabolic acidosis. (12871952)
2003
44
Cellular mechanisms of bone resorption induced by metabolic acidosis. (14629607)
2003
45
Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats. (12372777)
2002
46
Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning. (10686708)
1999
47
Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans. (8995736)
1997
48
Absence of high anion gap metabolic acidosis in severe ethylene glycol poisoning: a potential effect of simultaneous lithium carbonate ingestion. (8311092)
1994
49
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)
1994
50
An inherited disorder of isoleucine catabolism causing accumulation of alpha-methylacetoacetate and alpha-methyl-beta -hydroxybutyrate, and intermittent metabolic acidosis. (4690360)
1973

Genetic Variations for Metabolic Acidosis

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Expression for genes affiliated with Metabolic Acidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for genes affiliated with Metabolic Acidosis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Metabolic Acidosis

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1furosemide44 49 59 28 11 2415.9CA2, SLC13A2, ALB, AQP2
2hydrochlorothiazide44 49 28 11 2414.8CA2, ALB, AQP2
3dansylamide44 1111.8CA2, ALB
4alpha lipoic acid4410.8OGDH, PDP1, GSS
5isocitrate4410.8OGDH, AKR1A1, GSS
6sodium bicarbonate44 1111.8SLC9A3, AKR1A1, CA2
7urea44 11 2412.8AQP2, ALB, GLS2, CA2
8acetoacetate4410.8HMGCL, PDP1
9pyruvate4410.8CA2, OGDH, PDP1, AKR1A1, MLYCD
10sodium44 2411.8SCNN1G, WNK4, SLC9A3, SLC13A2, ALB, AQP2
11pyroglutamate4410.8OPLAH, GSS
12citrate4410.8ALB, CA2, OGDH, PDP1, AKR1A1, GLS2
13amiloride44 28 1112.8CA2, SCNN1G, SLC9A3
14alpha-ketoglutarate4410.8OGDH, PDP1, GLS2
15malate4410.8CA2, OGDH, AKR1A1
16chloride4410.8AQP2, SLC9A3, WNK4, CA2
17adp44 28 2412.8OGDH, PDP1, OPLAH, ATP6AP1, ATP6V1B1, WNK4
18fatty acid4410.8OGDH, PDP1, MLYCD, ALB, GSS
19potassium44 11 2412.8AQP2, ALB, SLC9A3, WNK4, ATP6AP1
20creatinine4410.8CA2, OGDH, OPLAH, AKR1A1, SLC9A3, ALB
21bicarbonate4410.8CA2, AKR1A1, ATP6AP1, GLS2, SLC9A3, ALB
22hydrogen44 2411.8CA2, OGDH, PDP1, SLC9A3, AQP2
23atp44 2811.8CA2, OGDH, PDP1, OPLAH, ATP6AP1, SLC9A3
24glutamine4410.8CA2, OGDH, PDP1, AKR1A1, GLS2, SLC9A3
25glucose4410.8OGDH, PDP1, FBP1, MLYCD, GLS2, SLC9A3
262-oxo acid4410.8OGDH, PDP1
27lactate4410.8CA2, OGDH, PDP1, AKR1A1, GLS2, SLC9A3
28dicarboxylate4410.8MLYCD, SLC13A2
29cysteine4410.8CA2, SCNN1G, OPLAH, AKR1A1, HMGCL, SLC9A3
30lipoamide44 2411.7OGDH, PDP1
31succinate4410.7SLC13A2, AKR1A1, OGDH
32serine4410.7CA2, OGDH, PDP1, AKR1A1, WNK4, SLC9A3
33glutamate4410.7CA2, OGDH, OPLAH, AKR1A1, GLS2, GSS
34dihydrolipoamide44 2411.7PDP1, OGDH
35alanine4410.7CA2, PDP1, AKR1A1, SLC9A3, ALB, AQP2
36aspartate4410.7ALB, GLS2, AKR1A1, OGDH, CA2
37l-glutamic acid28 11 2412.7OPLAH, GLS2, GSS
38carnitine4410.7MLYCD, PDP1, OGDH
39adenylate4410.7CA2, OGDH, AKR1A1, SLC9A3, AQP2
40oxygen44 2411.6CA2, OGDH, PDP1, AKR1A1, GLS2, GSS
41glucose 6-phosphate44 2411.6GLS2, AKR1A1, OGDH
42carbon dioxide44 2411.6CA2, OGDH, MLYCD
43nad+4410.6AKR1A1, PDP1, OGDH
44azide4410.6AKR1A1, CA2
45thiamine pyrophosphate44 2411.6OGDH, PDP1
46ethacrynic acid44 1111.5AKR1A1, ALB
47thiazide4410.4WNK4, CA2
48mannitol44 1111.3SLC9A3, ALB
49calcium44 49 11 2413.3CA2, OGDH, PDP1, ATP6AP1, ATP6V1B1, SLC9A3
50gliclazide44 49 1112.1ALB, PDP1

GO Terms for genes affiliated with Metabolic Acidosis

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16Gene Ontology
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Cellular components related to Metabolic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting V-type ATPase, V1 domainGO:03318010.4ATP6V1B1, ATP6AP1
2apical plasma membraneGO:01632410.3AQP2, SLC9A3, ATP6V1B1, AKR1A1, SCNN1G
3mitochondrial matrixGO:00575910.1OGDH, PDP1, MLYCD, GLS2, HMGCL

Biological processes related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1distal tubule morphogenesisGO:07215610.6WNK4, KLHL3
2transmembrane transportGO:05508510.5SCNN1G, ATP6V1B1, SLC9A3, SLC13A2, ALB, AQP2
3excretionGO:00758810.5SCNN1G, ATP6V1B1, AQP2
4small molecule metabolic processGO:04428110.5GSS, CA2, OGDH, PDP1, OPLAH, FBP1
5renal sodium ion absorptionGO:07029410.5KLHL3, WNK4
6regulation of pHGO:00688510.4SLC9A3, ATP6V1B1
7ion homeostasisGO:05080110.4KLHL3, WNK4
8glutathione biosynthetic processGO:00675010.2GSS, OPLAH

Products for genes affiliated with Metabolic Acidosis

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Sources for Metabolic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet