MCID: MTB004
MIFTS: 48

Metabolic Acidosis malady

Metabolic diseases category

Summaries for Metabolic Acidosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when... more...

MalaCards: Metabolic Acidosis is related to lactic acidosis and renal tubular acidosis. An important gene associated with Metabolic Acidosis is FBP1 (fructose-1,6-bisphosphatase 1), and among its related pathways are Glutathione synthesis and recycling and Glycolysis and gluconeogenesis (short map). The compounds furosemide and hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 A lactic acidosis that has material basis in high levels of acid.

Aliases & Classifications for Metabolic Acidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

metabolic acidosis 8 10 44 60


External Ids:

Disease Ontology8 DOID:0050758

Related Diseases for Metabolic Acidosis

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17GeneCards, 18GeneDecks
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Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1lactic acidosis30.5OGDH
2renal tubular acidosis30.5ATP6V1B1, CA2
3hypertension30.2SCNN1G, WNK4, ALB
4glutathione synthetase deficiency30.2GSS, OPLAH
5diabetes mellitus30.2ALB, SLC9A3, GLS2, FBP1, PDP1
6hypokalemia30.1AQP2, SLC9A3, ATP6AP1
7hemolytic anemia30.1OPLAH, FBP1, GSS
8hypoglycemia29.9HMGCL, GLS2, MLYCD, FBP1
9deficiency anemia29.9CA2, ALB
10kidney disease10.5
11diabetic ketoacidosis10.4
12diarrhea10.3
13asthma10.3
14hyperglycemia10.2
15uremia10.2
16hypophosphatemia10.2
17cerebritis10.2
18peritonitis10.2
19status epilepticus10.1
20hyperphosphatemia10.1
21neuronitis10.1
22type 1 diabetes mellitus10.1
23duodenitis10.1
24beriberi10.1
25hepatitis10.1
26hypothyroidism10.1
27thyroiditis10.1
28hmg coa lyase deficiency10.1
29renal tubular acidosis with deafness10.1
30glutaric acidemia iic10.1
31pseudohypoaldosteronism10.0KLHL3, SCNN1G, WNK4
32galactosemia10.0ALB
33maple syrup urine disease10.0HMGCL
34liddle syndrome10.0WNK4, SCNN1G, KLHL3
35nephrocalcinosis10.0ATP6V1B1, CA2
36cystic fibrosis10.0AQP2, ALB, SLC9A3, ATP6AP1, PDP1, CA2
37tuberculosis10.0ALB, AKR1A1, PDP1, OGDH
38essential hypertension10.0WNK4, ALB, AQP2
39liver cirrhosis10.0PDP1, AKR1A1, ALB, AQP2
40renal tubular acidosis, distal10.0ATP6V1B1, CA2
41pseudohypoaldosteronism type ii10.0WNK4
42primary biliary cirrhosis10.0OGDH
43hepatorenal syndrome10.0ALB
44diabetic nephropathy10.0AQP2, ALB, SLC9A3
45primary hyperoxaluria10.0CA2, SLC9A3, ALB, AQP2
46pasteurellosis10.0PDP1
47burns9.9
48periventricular leukomalacia9.9
49plasmodium malariae malaria9.9
50renal osteodystrophy9.9

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to metabolic acidosis

Clinical Features for Metabolic Acidosis

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Drugs & Therapeutics for Metabolic Acidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Metabolic Acidosis

Drug clinical trials:

Search ClinicalTrials for Metabolic Acidosis

Search NIH Clinical Center for Metabolic Acidosis

Search CenterWatch for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

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Anatomical Context for Metabolic Acidosis

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32MalaCards
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MalaCards organs/tissues related to Metabolic Acidosis:

32
Kidney, Bone, Heart, Liver, Brain, Skeletal muscle, Lung, Thyroid, Testes, Breast, Cortex, Colon, Small intestine, Endothelial

Animal Models for Metabolic Acidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Metabolic Acidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3SCNN1G, AKR1A1, MLYCD, ATP6V1B1, WNK4, SLC9A3
2MP:000536710.0AQP2, CA2, SCNN1G, AKR1A1, ATP6V1B1, WNK4

Publications for Metabolic Acidosis

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50PubMed
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Articles related to Metabolic Acidosis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. (23393104)
2013
2
Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis. (23136003)
2013
3
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. (24077426)
2013
4
Euglycemic ketoacidosis as a cause of a metabolic acidosis in the Intensive Care Unit. (23364105)
2012
5
Effect of experimentally induced metabolic acidosis on aortic endothelial permeability and serum nitric oxide concentration in normal and high-cholesterol fed rabbits. (23056086)
2012
6
Prediction of neonatal metabolic acidosis in women with a singleton term pregnancy in cephalic presentation: an external validation study. (22639352)
2012
7
Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis. (22265568)
2012
8
Repeated intoxication presenting with azotemia, elevated serum osmolal gap, and metabolic acidosis with high anion gap: differential diagnosis, management, and prognosis. (20602169)
2012
9
Consequences and therapy of the metabolic acidosis of chronic kidney disease. (20526632)
2011
10
Massive necrosis of the upper gastrointestinal tract with acute gastric perforation and metabolic acidosis after hydrochloric acid (HCl) ingestion. (21348002)
2011
11
Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study. (21486492)
2011
12
The case mid R: a woman with severe metabolic acidosis. (20075963)
2010
13
Effects of chronic metabolic acidosis on splanchnic protein turnover and oxygen consumption in human beings. (20026114)
2010
14
Vascular calcification and metabolic acidosis in end stage renal disease. (19918300)
2009
15
Severe metabolic acidosis as a consequence of acute starvation in pregnancy. (18592261)
2009
16
The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. (19439519)
2009
17
Effects of nutritionally induced metabolic acidosis with or without glutamine infusion on acid-base balance, plasma amino acids, and plasma nonesterified fatty acids in sheep. (19028843)
2009
18
Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies. (19121476)
2009
19
Equivalent metabolic acidosis with four colloids and saline on ex vivo haemodilution. (19499860)
2009
20
Bedside detection of urine beta-hydroxybutyrate in diagnosing metabolic acidosis. (18637083)
2008
21
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle. (18650482)
2008
22
A review article: sevelamer hydrochloride and metabolic acidosis in dialysis patients. (19075639)
2008
23
Severe metabolic acidosis secondary to zinc phosphide poisoning. (18661613)
2008
24
Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis. (17669025)
2007
25
Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. (17255858)
2007
26
A newborn infant with protracted diarrhea and metabolic acidosis. (17236902)
2007
27
Visual blurring and metabolic acidosis after ingestion of bootlegged alcohol. (16441822)
2006
28
Sevelamer worsens metabolic acidosis in hemodialysis patients. (16736432)
2006
29
Nalidixic acid overdose and metabolic acidosis. (17175866)
2006
30
Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. (17061643)
2006
31
Chronic metabolic acidosis stimulated transcellular and solvent drag-induced calcium transport in the duodenum of female rats. (16675746)
2006
32
Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats. (15855660)
2005
33
Severe metabolic acidosis secondary to organophosphate poisoning. (16301295)
2005
34
Risks of chronic metabolic acidosis in patients with chronic kidney disease. (15882309)
2005
35
Severe metabolic acidosis resulting from a dislocated gastric band. (15130238)
2004
36
Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. (15153572)
2004
37
Dietary-induced metabolic acidosis decreases bone mineral density in mature ovariectomized ewes. (15592799)
2004
38
Diagnosing the cause of a hyperosmolar anion-gap metabolic acidosis. (14984636)
2003
39
Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. (12854843)
2003
40
A 37 year old man with intermittent abdominal pain and non-lactic, non-ketone, high anion gap metabolic acidosis. (16573458)
2003
41
Must metabolic acidosis be associated with malnutrition in haemodialysed patients? (12401862)
2002
42
Metabolic acidosis up-regulates PTH/PTHrP receptors in UMR 106-01 osteoblast-like cells. (12234287)
2002
43
Butoxyethanol ingestion with prolonged hyperchloremic metabolic acidosis treated with ethanol therapy. (11192467)
2000
44
Effect of metabolic acidosis on the growth hormone/IGF-I endocrine axis in skeletal growth centers. (10844596)
2000
45
Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies. (9541495)
1998
46
Hyperglycemia, ketosis and mild metabolic acidosis in two patients subsequently found not to require insulin. (2108273)
1990
47
The association of fetal and newborn metabolic acidosis with severe periventricular leukomalacia in the preterm newborn. (2183620)
1990
48
Absence of anion gap metabolic acidosis in severe methanol poisoning: a case report and review of the literature. (3555018)
1987
49
Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. (1674)
1976
50
Methanol poisoning. I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole. (2163)
1975

Genetic Variations for Metabolic Acidosis

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Expression for genes affiliated with Metabolic Acidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for genes affiliated with Metabolic Acidosis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Metabolic Acidosis

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1furosemide44 49 59 28 11 2415.9CA2, SLC13A2, ALB, AQP2
2hydrochlorothiazide44 49 28 11 2414.8CA2, ALB, AQP2
3dansylamide44 1111.8CA2, ALB
4alpha lipoic acid4410.8OGDH, PDP1, GSS
5isocitrate4410.8OGDH, AKR1A1, GSS
6sodium bicarbonate44 1111.8SLC9A3, AKR1A1, CA2
7urea44 11 2412.8AQP2, ALB, GLS2, CA2
8acetoacetate4410.8HMGCL, PDP1
9pyruvate4410.8CA2, OGDH, PDP1, AKR1A1, MLYCD
10sodium44 2411.8SCNN1G, WNK4, SLC9A3, SLC13A2, ALB, AQP2
11pyroglutamate4410.8OPLAH, GSS
12citrate4410.8ALB, CA2, OGDH, PDP1, AKR1A1, GLS2
13amiloride44 28 1112.8CA2, SCNN1G, SLC9A3
14alpha-ketoglutarate4410.8OGDH, PDP1, GLS2
15malate4410.8CA2, OGDH, AKR1A1
16chloride4410.8AQP2, SLC9A3, WNK4, CA2
17adp44 28 2412.8OGDH, PDP1, OPLAH, ATP6AP1, ATP6V1B1, WNK4
18fatty acid4410.8OGDH, PDP1, MLYCD, ALB, GSS
19potassium44 11 2412.8AQP2, ALB, SLC9A3, WNK4, ATP6AP1
20creatinine4410.8CA2, OGDH, OPLAH, AKR1A1, SLC9A3, ALB
21bicarbonate4410.8CA2, AKR1A1, ATP6AP1, GLS2, SLC9A3, ALB
22hydrogen44 2411.8CA2, OGDH, PDP1, SLC9A3, AQP2
23atp44 2811.8CA2, OGDH, PDP1, OPLAH, ATP6AP1, SLC9A3
24glutamine4410.8CA2, OGDH, PDP1, AKR1A1, GLS2, SLC9A3
25glucose4410.8OGDH, PDP1, FBP1, MLYCD, GLS2, SLC9A3
262-oxo acid4410.8OGDH, PDP1
27lactate4410.8CA2, OGDH, PDP1, AKR1A1, GLS2, SLC9A3
28dicarboxylate4410.8MLYCD, SLC13A2
29cysteine4410.8CA2, SCNN1G, OPLAH, AKR1A1, HMGCL, SLC9A3
30lipoamide44 2411.7OGDH, PDP1
31succinate4410.7SLC13A2, AKR1A1, OGDH
32serine4410.7CA2, OGDH, PDP1, AKR1A1, WNK4, SLC9A3
33glutamate4410.7CA2, OGDH, OPLAH, AKR1A1, GLS2, GSS
34dihydrolipoamide44 2411.7PDP1, OGDH
35alanine4410.7CA2, PDP1, AKR1A1, SLC9A3, ALB, AQP2
36aspartate4410.7ALB, GLS2, AKR1A1, OGDH, CA2
37l-glutamic acid28 11 2412.7OPLAH, GLS2, GSS
38carnitine4410.7MLYCD, PDP1, OGDH
39adenylate4410.7CA2, OGDH, AKR1A1, SLC9A3, AQP2
40oxygen44 2411.6CA2, OGDH, PDP1, AKR1A1, GLS2, GSS
41glucose 6-phosphate44 2411.6GLS2, AKR1A1, OGDH
42carbon dioxide44 2411.6CA2, OGDH, MLYCD
43nad+4410.6AKR1A1, PDP1, OGDH
44azide4410.6AKR1A1, CA2
45thiamine pyrophosphate44 2411.6OGDH, PDP1
46ethacrynic acid44 1111.5AKR1A1, ALB
47thiazide4410.4WNK4, CA2
48mannitol44 1111.3SLC9A3, ALB
49calcium44 49 11 2413.3CA2, OGDH, PDP1, ATP6AP1, ATP6V1B1, SLC9A3
50gliclazide44 49 1112.1ALB, PDP1

GO Terms for genes affiliated with Metabolic Acidosis

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16Gene Ontology
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Cellular components related to Metabolic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting V-type ATPase, V1 domainGO:03318010.4ATP6V1B1, ATP6AP1
2apical plasma membraneGO:01632410.3AQP2, SLC9A3, ATP6V1B1, AKR1A1, SCNN1G
3mitochondrial matrixGO:00575910.1OGDH, PDP1, MLYCD, GLS2, HMGCL

Biological processes related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1distal tubule morphogenesisGO:07215610.6WNK4, KLHL3
2transmembrane transportGO:05508510.5SCNN1G, ATP6V1B1, SLC9A3, SLC13A2, ALB, AQP2
3excretionGO:00758810.5SCNN1G, ATP6V1B1, AQP2
4small molecule metabolic processGO:04428110.5GSS, CA2, OGDH, PDP1, OPLAH, FBP1
5renal sodium ion absorptionGO:07029410.5KLHL3, WNK4
6regulation of pHGO:00688510.4SLC9A3, ATP6V1B1
7ion homeostasisGO:05080110.4KLHL3, WNK4
8glutathione biosynthetic processGO:00675010.2GSS, OPLAH

Products for genes affiliated with Metabolic Acidosis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Metabolic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet