MCID: MTB004
MIFTS: 48

Metabolic Acidosis malady

Metabolic category

Summaries for Metabolic Acidosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when... more...

MalaCards: Metabolic Acidosis is related to renal tubular acidosis and glutathione synthetase deficiency. An important gene associated with Metabolic Acidosis is FBP1 (fructose-1,6-bisphosphatase 1), and among its related pathways are Glutathione synthesis and recycling and Glycolysis and gluconeogenesis (short map). The compounds furosemide and hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 A lactic acidosis that has material basis in high levels of acid.

Aliases & Classifications for Metabolic Acidosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

metabolic acidosis 8 10 45 61


External Ids:

Disease Ontology8 DOID:0050758

Related Diseases for Metabolic Acidosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1renal tubular acidosis30.5ATP6V1B1, CA2
2glutathione synthetase deficiency30.4OPLAH, GSS
3hypokalemia30.2AQP2, SLC9A3, ATP6AP1
4renal tubular acidosis, distal30.2CA2, ATP6V1B1
5hypoglycemia29.9FBP1, MLYCD, GLS2, HMGCL
6deficiency anemia29.9ALB, CA2
7diabetic ketoacidosis10.5
8asthma10.4
9sepsis10.3
10uremia10.3
11ethylene glycol poisoning10.3
12methanol poisoning10.3
13hypophosphatemia10.2
14hypoxia10.2
15septic shock10.2
16status epilepticus10.1
17hyperphosphatemia10.1
18n syndrome10.1
19beriberi10.1
20short syndrome10.1
21hmg coa lyase deficiency10.1
22hypoaldosteronism10.1
23mental retardation10.1
24short stature10.1
25glutaric acidemia iic10.1
26lactic acidosis10.0OGDH
27pseudohypoaldosteronism10.0WNK4, SCNN1G, KLHL3
28hypertension10.0SCNN1G, WNK4, ALB
29galactosemia10.0ALB
30maple syrup urine disease10.0HMGCL
31liddle syndrome10.0WNK4, SCNN1G, KLHL3
32nephrocalcinosis10.0ATP6V1B1, CA2
33hemolytic anemia10.0OPLAH, GSS, FBP1
34cystic fibrosis10.0ALB, PDP1, ATP6AP1, SLC9A3, AQP2, CA2
35tuberculosis10.0PDP1, ALB, OGDH, AKR1A1
36essential hypertension10.0AQP2, ALB, WNK4
37liver cirrhosis10.0ALB, PDP1, AQP2, AKR1A1
38pseudohypoaldosteronism type ii10.0WNK4
39primary biliary cirrhosis10.0OGDH
40periventricular leukomalacia10.0
41renal osteodystrophy10.0
42cholera10.0
43acute diarrhea10.0
44leber congenital amaurosis10.0
45adult respiratory distress syndrome10.0
46quadriplegia10.0
47nephronophthisis10.0
48beta thalassemia10.0
49chronic wasting disease10.0
50chorioamnionitis10.0

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to metabolic acidosis

Clinical Features for Metabolic Acidosis

Drugs & Therapeutics for Metabolic Acidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Metabolic Acidosis

Drug clinical trials:

Search ClinicalTrials for Metabolic Acidosis

Search NIH Clinical Center for Metabolic Acidosis

Search CenterWatch for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Anatomical Context for Metabolic Acidosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Metabolic Acidosis:

33
Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Breast, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Metabolic Acidosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Metabolic Acidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3CA2, SCNN1G, AKR1A1, MLYCD, ATP6V1B1, WNK4
2MP:000536710.0CA2, SCNN1G, AKR1A1, ATP6V1B1, WNK4, SLC9A3

Publications for Metabolic Acidosis

Sources:
51PubMed
See all sources

Articles related to Metabolic Acidosis:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats. (24026074)
2013
2
Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis. (23804448)
2013
3
Severe anion gap metabolic acidosis from acetaminophen use secondary to 5-oxoproline (pyroglutamic acid) accumulation. (22986610)
2012
4
Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water. (22457081)
2012
5
Intractable metabolic acidosis in a patient with colovesical fistula. (23254529)
2012
6
Effects of tight versus non tight control of metabolic acidosis on early renal function after kidney transplantation. (23351673)
2012
7
Potential inaccuracies in chloride measurements in patients with severe metabolic acidosis. (22778953)
2012
8
A woman with generalised weakness, hypokalaemia, and metabolic acidosis. (22498955)
2012
9
Treatment of acute metabolic acidosis: a pathophysiologic approach. (22945490)
2012
10
Unexpectedly severe metabolic acidosis associated with sodium thiosulfate therapy in a patient with calcific uremic arteriolopathy. (21338397)
2011
11
Extreme hyponatremia with moderate metabolic acidosis during hysteroscopic myomectomy -A case report-. (21738849)
2011
12
Characterization of temporal evolution of metabolic acidosis in adult patients with severe diabetic ketoacidosis admitted to the intensive care unit: not quite done. (21967878)
2011
13
Resuscitation with balanced electrolyte solution prevents hyperchloremic metabolic acidosis in patients with diabetic ketoacidosis. (20825879)
2011
14
No effect of metabolic acidosis on nitric oxide production in hypoxic and hyperoxic lung regions in pigs. (21251235)
2011
15
Graded classification of fetal heart rate tracings: association with neonatal metabolic acidosis and neurologic morbidity. (19716539)
2010
16
Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct. (20592712)
2010
17
Metabolic acidosis in sheep alters expression of renal and skeletal muscle amino acid enzymes and transporters. (19820050)
2010
18
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion. (20462967)
2010
19
Profound intraoperative metabolic acidosis and hypotension in a child undergoing multilevel spinal fusion. (19841685)
2009
20
Combined glycolytic production of lactate(-) and ATP(4-) derived protons (= dissociated lactic acid) is the only cause of metabolic acidosis of exercise--a note on the OH(-) absorbing function of lactate (1-) production. (18680794)
2008
21
Intraoperative metabolic acidosis induced by chronic topiramate intake in neurosurgical patients. (18157030)
2008
22
Chronic metabolic acidosis may be the cause of cachexia: body fluid pH correction may be an effective therapy. (18180110)
2008
23
Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula. (17891350)
2007
24
Change in heart rate variability in relation to a significant ST-event associates with newborn metabolic acidosis. (17506791)
2007
25
Changing the priming solution from Ringer's to Hartmann's solution is associated with less metabolic acidosis during cardiopulmonary bypass. (18666740)
2007
26
An improved approach to the patient with metabolic acidosis: a need for four amendments. (16736445)
2006
27
Predicting the risk of metabolic acidosis for newborns based on fetal heart rate signal classification using support vector machines. (16686410)
2006
28
Effects of correction of metabolic acidosis on blood urea and bone metabolism in patients with mild to moderate chronic kidney disease: a prospective randomized single blind controlled trial. (16526312)
2006
29
Lactate production and exercise-induced metabolic acidosis: guilty or not guilty? (16204609)
2005
30
Topiramate and metabolic acidosis: a case series and review of the literature. (15675937)
2005
31
Molybdenum cofactor deficiency presenting with severe metabolic acidosis and intracranial hemorrhage. (15794186)
2005
32
Accidental acute metabolic acidosis due to inappropriate selection of bicarbonate concentrate. (16180553)
2005
33
Stimulation of renal sulfate secretion by metabolic acidosis requires Na+/H+ exchange induction and carbonic anhydrase. (15741604)
2005
34
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. (16277723)
2005
35
Metabolic acidosis due to topiramate. (15499701)
2004
36
PCO2 and [K+]p in metabolic acidosis: certainty for the first and uncertainty for the other. (15153580)
2004
37
What mechanism is responsible for the decreased BE/[La] ratio in exercise-induced metabolic acidosis? (15475560)
2004
38
Chronic metabolic acidosis increases mRNA levels for components of the ubiquitin-mediated proteolytic pathway in skeletal muscle of dairy cows. (14988446)
2004
39
Biochemistry of exercise-induced metabolic acidosis. (15308499)
2004
40
Is an intravenous fluid bolus of albumin or normal saline beneficial in the treatment of metabolic acidosis in a normovolaemic newborn? (15321875)
2004
41
Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: a randomized placebo-control trial. (12874466)
2003
42
Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis. (12793889)
2003
43
Effect of the correction of metabolic acidosis on nutritional status in elderly patients with chronic renal failure. (12382214)
2002
44
Metabolic acidosis, core-peripheral temperature difference and blood pressure response to albumin infusion in hypotensive, very premature infants. (11723846)
2001
45
Correction of metabolic acidosis and its effect on albumin in chronic hemodialysis patients. (9428449)
1998
46
Metabolic acidosis and urinary acidification defect during the course of hemorrhagic fever with renal syndrome. (9741543)
1998
47
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. (9215686)
1997
48
Impact of metabolic acidosis on serum albumin and other nutritional parameters in long-term CAPD patients. (9360692)
1997
49
The role of metabolic acidosis in causing uremic hyperphosphatemia. (3007964)
1986
50
Hemolytic anemia, recurrent metabolic acidosis, and incomplete albinism associated with glutathione synthetase deficiency. (6882923)
1983

Genetic Variations for Metabolic Acidosis

Expression for genes affiliated with Metabolic Acidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for genes affiliated with Metabolic Acidosis

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Metabolic Acidosis

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1furosemide45 50 60 29 11 2415.9SLC13A2, CA2, AQP2, ALB
2hydrochlorothiazide45 50 29 11 2414.8AQP2, CA2, ALB
3dansylamide45 1111.8ALB, CA2
4alpha lipoic acid4510.8OGDH, PDP1, GSS
5isocitrate4510.8AKR1A1, GSS, OGDH
6sodium bicarbonate45 1111.8AKR1A1, SLC9A3, CA2
7urea45 11 2412.8AQP2, ALB, CA2, GLS2
8acetoacetate4510.8PDP1, HMGCL
9pyruvate4510.8CA2, OGDH, PDP1, AKR1A1, MLYCD
10sodium45 2411.8SCNN1G, SLC13A2, ALB, AQP2, WNK4, SLC9A3
11pyroglutamate4510.8OPLAH, GSS
12citrate4510.8GLS2, ALB, SLC13A2, AKR1A1, PDP1, OGDH
13amiloride45 29 1112.8CA2, SCNN1G, SLC9A3
14alpha-ketoglutarate4510.8OGDH, GLS2, PDP1
15malate4510.8CA2, AKR1A1, OGDH
16chloride4510.8SLC9A3, WNK4, CA2, AQP2
17adp45 29 2412.8ATP6AP1, OPLAH, PDP1, ATP6V1B1, WNK4, GSS
18fatty acid4510.8ALB, PDP1, OGDH, MLYCD, GSS
19potassium45 11 2412.8AQP2, SLC9A3, WNK4, ATP6AP1, ALB
20creatinine4510.8AQP2, ALB, SLC9A3, CA2, AKR1A1, OGDH
21bicarbonate4510.8AKR1A1, ALB, SLC9A3, GLS2, ATP6AP1, CA2
22hydrogen45 2411.8PDP1, SLC9A3, CA2, OGDH, AQP2
23atp45 2911.8GSS, OGDH, CA2, PDP1, OPLAH, ATP6AP1
24glutamine4510.8SLC9A3, GLS2, AKR1A1, PDP1, OGDH, CA2
25glucose4510.8AQP2, ALB, SLC9A3, GLS2, MLYCD, FBP1
26lipoamide45 2411.8OGDH, PDP1
27lactate4510.8ALB, GLS2, PDP1, OGDH, SLC9A3, CA2
28dicarboxylate4510.8SLC13A2, MLYCD
29cysteine4510.8GSS, ALB, SLC13A2, SLC9A3, HMGCL, AKR1A1
302-oxo acid4510.7PDP1, OGDH
31succinate4510.7SLC13A2, OGDH, AKR1A1
32serine4510.7SLC9A3, AQP2, GSS, OGDH, CA2, WNK4
33glutamate4510.7OGDH, OPLAH, AKR1A1, GLS2, CA2, GSS
34dihydrolipoamide45 2411.7PDP1, OGDH
35alanine4510.7AKR1A1, PDP1, ALB, AQP2, SLC9A3, CA2
36aspartate4510.7ALB, CA2, OGDH, AKR1A1, GLS2
37l-glutamic acid29 11 2412.7OPLAH, GLS2, GSS
38carnitine4510.7OGDH, PDP1, MLYCD
39adenylate4510.7AQP2, SLC9A3, AKR1A1, CA2, OGDH
40oxygen45 2411.6OGDH, PDP1, AKR1A1, CA2, GLS2, GSS
41glucose 6-phosphate45 2411.6AKR1A1, GLS2, OGDH
42carbon dioxide45 2411.6CA2, MLYCD, OGDH
43nad+4510.6PDP1, OGDH, AKR1A1
44azide4510.6AKR1A1, CA2
45ethacrynic acid45 1111.5AKR1A1, ALB
46thiamine pyrophosphate45 2411.5OGDH, PDP1
47thiazide4510.4WNK4, CA2
48mannitol45 1111.3ALB, SLC9A3
49calcium45 50 11 2413.3PDP1, CA2, OGDH, AQP2, SLC9A3, ALB
50gliclazide45 50 1112.1ALB, PDP1

GO Terms for genes affiliated with Metabolic Acidosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Metabolic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting V-type ATPase, V1 domainGO:03318010.4ATP6V1B1, ATP6AP1
2apical plasma membraneGO:01632410.3SLC9A3, SCNN1G, AKR1A1, ATP6V1B1, AQP2
3mitochondrial matrixGO:00575910.1HMGCL, OGDH, PDP1, MLYCD, GLS2

Biological processes related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1distal tubule morphogenesisGO:07215610.6WNK4, KLHL3
2transmembrane transportGO:05508510.5ALB, SLC13A2, SLC9A3, ATP6V1B1, SCNN1G, AQP2
3excretionGO:00758810.5SCNN1G, ATP6V1B1, AQP2
4small molecule metabolic processGO:04428110.5PDP1, OGDH, OPLAH, FBP1, MLYCD, GLS2
5ion homeostasisGO:05080110.5WNK4, KLHL3
6regulation of pHGO:00688510.4SLC9A3, ATP6V1B1
7renal sodium ion absorptionGO:07029410.4KLHL3, WNK4
8glutathione biosynthetic processGO:00675010.2OPLAH, GSS

Products for genes affiliated with Metabolic Acidosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Metabolic Acidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet