MCID: MTB004
MIFTS: 45

Metabolic Acidosis malady

Metabolic diseases category
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Summaries for Metabolic Acidosis

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Wikipedia:65 In medicine, metabolic acidosis is a condition that occurs when the body produces excessive quantities... more...

MalaCards based summary: Metabolic Acidosis is related to glutathione synthetase deficiency and hemolytic anemia. An important gene associated with Metabolic Acidosis is FBP1 (fructose-1,6-bisphosphatase 1), and among its related pathways are Glutathione metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds pyroglutamate and buthionine sulfoximine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related mouse phenotype renal/urinary system.

Disease Ontology:8 A lactic acidosis that has material basis in high levels of acid.

Aliases & Classifications for Metabolic Acidosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS
See all sources

Metabolic Acidosis, Aliases & Descriptions:

Name: Metabolic Acidosis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:0050758

Related Diseases for Metabolic Acidosis

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Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to metabolic acidosis

Symptoms for Metabolic Acidosis

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Drugs & Therapeutics for Metabolic Acidosis

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Drug clinical trials:

Search ClinicalTrials for Metabolic Acidosis

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

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Anatomical Context for Metabolic Acidosis

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MalaCards organs/tissues related to Metabolic Acidosis:

32
Kidney, Bone, Heart, Liver, Brain, Skeletal muscle, Lung, Thyroid, Endothelial, Cortex, Small intestine, Colon, Breast

Animal Models for Metabolic Acidosis or affiliated genes

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MGI Mouse Phenotypes related to Metabolic Acidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.2SLC13A2, WNK4, AQP2, ATP6V1B1

Publications for Metabolic Acidosis

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Articles related to Metabolic Acidosis:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis. (25405229)
2014
2
Acute metabolic acidosis in a GLUT2-deficient patient with Fanconi-Bickel syndrome: new pathophysiology insights. (25165176)
2014
3
Phosphate binders and metabolic acidosis in patients undergoing maintenance hemodialysis-sevelamer hydrochloride, calcium carbonate, and bixalomer. (24980286)
2014
4
Intractable metabolic acidosis in a child with propionic acidemia undergoing liver transplantation -a case report-. (24101962)
2013
5
An unusual case of refractory metabolic acidosis. (24082513)
2013
6
Severe high anion gap metabolic acidosis in pregnancy. (23689158)
2013
7
Negative anion gap metabolic acidosis and low level of salicylate cannot ignore salicylate toxicity! (24360318)
2013
8
Metabolic acidosis in toluene sniffing. (23778000)
2013
9
Evaluation of acid-base status in brain dead donors and the impact of metabolic acidosis on organ retrieval. (23652168)
2013
10
Factors related to post-operative metabolic acidosis following major abdominal surgery. (22985420)
2012
11
Euglycemic ketoacidosis as a cause of a metabolic acidosis in the Intensive Care Unit. (23364105)
2012
12
Unexpectedly severe metabolic acidosis associated with sodium thiosulfate therapy in a patient with calcific uremic arteriolopathy. (21338397)
2011
13
Metabolic acidosis in healthy mules under general anaesthesia with halothane. (21831054)
2011
14
Evaluation of metabolic acidosis in patients with a kidney graft: comparison of the bicarbonate-based and strong ion-based methods. (21620052)
2011
15
Graded classification of fetal heart rate tracings: association with neonatal metabolic acidosis and neurologic morbidity. (19716539)
2010
16
Metabolic acidosis in sepsis. (20509840)
2010
17
Metabolic acidosis as a complication of intravenous dextrose administration in a patient with insulinoma. (20972720)
2010
18
Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. (20392797)
2010
19
Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major. (19934389)
2010
20
Vascular calcification and metabolic acidosis in end stage renal disease. (19918300)
2009
21
Severe metabolic acidosis as a consequence of acute starvation in pregnancy. (18592261)
2009
22
Profound intraoperative metabolic acidosis and hypotension in a child undergoing multilevel spinal fusion. (19841685)
2009
23
Stewart's physicochemical approach in neurosurgical patients with hyperchloremic metabolic acidosis during propofol anesthesia. (18157018)
2008
24
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
25
Paracetamol-induced 5-oxoprolinuira and high anion gap metabolic acidosis in a child on a ketogenic diet. (18583640)
2008
26
Unmeasured anions account for most of the metabolic acidosis in patients with hyperlactatemia. (17334550)
2007
27
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. (17717564)
2007
28
Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula. (17891350)
2007
29
Excess casein in the diet is not the unique cause of low-grade metabolic acidosis: role of a deficit in potassium citrate in a rat model. (16407650)
2006
30
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis. (16144966)
2006
31
Coma, metabolic acidosis and normal liver function in a child with a large serum acetaminophen level. (17052573)
2006
32
Hypovolemic shock and metabolic acidosis in a refugee secondary to O1 serotype Vibrio cholerae enteritis. (16841506)
2006
33
Serum ionized calcium in dogs with chronic renal failure and metabolic acidosis. (17123251)
2006
34
Lactate production and exercise-induced metabolic acidosis: guilty or not guilty? (16204609)
2005
35
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. (15983968)
2005
36
Hypophosphatemia and metabolic acidosis. (15834352)
2005
37
Lactic acid still remains the real cause of exercise-induced metabolic acidosis. (16105825)
2005
38
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
39
Quetiapine-induced diabetes with metabolic acidosis. (15107661)
2004
40
Metabolic acidosis of chronically hemodialyzed patients. (12649614)
2003
41
Diagnosing the cause of a hyperosmolar anion-gap metabolic acidosis. (14984636)
2003
42
Must metabolic acidosis be associated with malnutrition in haemodialysed patients? (12401862)
2002
43
46,XX gonadal dysgenesis, short stature, and recurrent metabolic acidosis in two sisters. (11223846)
2001
44
Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning. (10686708)
1999
45
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
46
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. (9215686)
1997
47
Absence of high anion gap metabolic acidosis in severe ethylene glycol poisoning: a potential effect of simultaneous lithium carbonate ingestion. (8311092)
1994
48
Influence of rapid correction of metabolic acidosis on serum osteocalcin level in chronic renal failure. (8555554)
1994
49
Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia. (1469097)
1992
50
Isoniazid toxicity presenting as seizures and metabolic acidosis. (2304098)
1990

Variations for Metabolic Acidosis

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Expression for genes affiliated with Metabolic Acidosis

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Expression patterns in normal tissues for genes affiliated with Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for genes affiliated with Metabolic Acidosis

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Pathways related to Metabolic Acidosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
9.8GSS, OPLAH
2
Show member pathways
8.2ATP6V1B1, AQP2, WNK4, SLC13A2
3
Show member pathways
7.9MLYCD, ATP6V1B1, FBP1, PDP1, GSS, OPLAH

Compounds for genes affiliated with Metabolic Acidosis

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Compounds related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1pyroglutamate4410.1OPLAH, GSS
2buthionine sulfoximine4410.1OPLAH, GSS
3gamma-glutamylcysteine44 24 1112.0GSS, OPLAH
4alpha lipoic acid449.9PDP1, GSS
5l-glutamic acid28 24 1111.9OPLAH, GSS
6furosemide44 61 28 50 24 1114.8SLC13A2, AQP2
7dicarboxylate449.7MLYCD, SLC13A2
8lithium44 50 24 1112.6AQP2, SLC13A2
9carnitine449.5PDP1, MLYCD
10acyl-coa449.4PDP1, MLYCD
11biotin44 24 1111.3GSS, AQP2
12fatty acid449.3GSS, PDP1, MLYCD
13atp44 2810.2OPLAH, GSS, PDP1, AQP2
14cysteine449.0AQP2, GSS, OPLAH, SLC13A2
15glucose448.9PDP1, AQP2, FBP1, MLYCD
16Phosphate248.9OPLAH, GSS, PDP1, FBP1, ATP6V1B1
17sodium44 249.9SLC13A2, WNK4, AQP2
18Water248.8ATP6V1B1, FBP1, AQP2, PDP1, OPLAH
19Adenosine triphosphate24 119.7OPLAH, GSS, WNK4, ATP6V1B1
20magnesium44 24 1110.7AQP2, WNK4, PDP1
21serine448.4GSS, PDP1, WNK4, AQP2
22adp44 28 2410.3ATP6V1B1, WNK4, PDP1, GSS, OPLAH

GO Terms for genes affiliated with Metabolic Acidosis

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Cellular components related to Metabolic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.6ATP6V1B1, FBP1, GSS, KLHL3, OPLAH
2extracellular vesicular exosomeGO:0700628.0ATP6V1B1, FBP1, AQP2, GSS, SLC13A2

Biological processes related to Metabolic Acidosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1glutathione biosynthetic processGO:0067509.9OPLAH, GSS
2glutathione derivative biosynthetic processGO:19016879.8OPLAH, GSS
3agingGO:0075689.6AQP2, GSS
4distal tubule morphogenesisGO:0721569.5WNK4, KLHL3
5ion homeostasisGO:0508019.5KLHL3, WNK4
6renal sodium ion absorptionGO:0702949.5WNK4, KLHL3
7excretionGO:0075889.4AQP2, ATP6V1B1
8transmembrane transportGO:0550858.7ATP6V1B1, SLC13A2, AQP2
9small molecule metabolic processGO:0442818.5GSS, PDP1, FBP1, MLYCD, OPLAH

Molecular functions related to Metabolic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055248.4OPLAH, GSS, WNK4, ATP6V1B1

Products for genes affiliated with Metabolic Acidosis

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Sources for Metabolic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet