MCID: MTB004
MIFTS: 47

Metabolic Acidosis

Categories: Metabolic diseases

Aliases & Classifications for Metabolic Acidosis

MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050758

Summaries for Metabolic Acidosis

Disease Ontology : 12 A lactic acidosis that has material basis in high levels of acid.

MalaCards based summary : Metabolic Acidosis is related to glutathione synthetase deficiency and lactic acidosis. An important gene associated with Metabolic Acidosis is GSS (Glutathione Synthetase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 72 Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or... more...

Related Diseases for Metabolic Acidosis

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 glutathione synthetase deficiency 11.3
2 lactic acidosis 11.0
3 renal tubular acidosis, distal 11.0
4 fructose-1,6-bisphosphatase deficiency 11.0
5 hmg-coa lyase deficiency 10.9
6 glutaric acidemia iic 10.9
7 malonyl-coa decarboxylase deficiency 10.9
8 renal tubular acidosis, distal, ad 10.9
9 renal tubular acidosis with deafness 10.9
10 3-methylglutaconic aciduria, type i 10.8
11 malignant hyperthermia susceptibility 1 10.8
12 mitochondrial complex i deficiency due to acad9 deficiency 10.8
13 hawkinsinuria 10.8
14 pseudohypoaldosteronism, type iid 10.8
15 trifunctional protein deficiency 10.8
16 fumarase deficiency 10.8
17 hyperammonemia due to carbonic anhydrase va deficiency 10.8
18 renal tubular acidosis, distal, ar 10.8
19 hydroxykynureninuria 10.7
20 autosomal dominant medullary cystic kidney disease without hyperuricemia 10.7
21 pseudohypoaldosteronism, type iie 10.7
22 nephronophthisis 2, infantile 10.7
23 diarrhea 3, secretory sodium, congenital, syndromic 10.7
24 combined oxidative phosphorylation deficiency 2 10.7
25 d-glycericacidemia 10.7
26 d-glyceric aciduria 10.7
27 combined oxidative phosphorylation deficiency 5 10.7
28 pseudohypoaldosteronism, type i 10.7
29 holocarboxylase synthetase deficiency 10.7
30 pseudohypoaldosteronism, type iic 10.7
31 combined oxidative phosphorylation deficiency 3 10.7
32 hsd10 mitochondrial disease 10.7
33 cpt ii deficiency, infantile 10.7
34 sudden cardiac failure, infantile 10.7
35 pseudohypoaldosteronism, type iia 10.7
36 isovaleric acidemia 10.7
37 nephronophthisis 10.7
38 mitochondrial dna depletion syndrome 6 10.7
39 mitochondrial pyruvate carrier deficiency 10.7
40 slc4a1-associated distal renal tubular acidosis 10.7
41 leigh syndrome, french-canadian type 10.7
42 alpha-ketoglutarate dehydrogenase deficiency 10.7
43 riboflavin deficiency 10.7
44 methylmalonyl-coa epimerase deficiency 10.7
45 mitochondrial myopathy with lactic acidosis 10.7
46 renal tubular acidosis, distal, autosomal recessive 10.7
47 2-methyl-3-hydroxybutyric aciduria 10.7
48 pseudohypoaldosteronism, type iib 10.7
49 autosomal dominant medullary cystic kidney disease with hyperuricemia 10.7
50 corticosterone methyloxidase deficiency 10.7

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis

Symptoms & Phenotypes for Metabolic Acidosis

MGI Mouse Phenotypes related to Metabolic Acidosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ALB AQP2 ATP6V0A4 ATP6V1B1 BTD CA2
2 renal/urinary system MP:0005367 9.32 SLC4A1 SLC4A4 SLC9A3 WNK4 ALB AQP2

Drugs & Therapeutics for Metabolic Acidosis

Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 282)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3 Parecoxib Approved Phase 4 198470-84-7
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6 Racepinephrine Approved Phase 4
7
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
8
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
9
Insulin Glargine Approved Phase 4 160337-95-1
10
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
11
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
12
Ephedrine Approved Phase 4,Phase 2,Phase 3 299-42-3 9294
13
Oxymetazoline Approved Phase 4,Phase 2,Phase 3 1491-59-4 4636
14
Phenylephrine Approved Phase 4,Phase 2,Phase 3 59-42-7 6041
15
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3 90-82-4 7028
16
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
17
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
18
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
19
Insulin-glulisine Approved Phase 4 207748-29-6
20
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
21
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
22
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
23
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
24
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
25
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
26
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
28
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8 1130
29
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
30
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
31 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
32 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
33 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
34 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
35 Ophthalmic Solutions Phase 4,Phase 3
36 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
37 Plasma-lyte 148 Phase 4,Phase 3
38 Antipsychotic Agents Phase 4
39 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
40 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
41 Psychotropic Drugs Phase 4
42 Tranquilizing Agents Phase 4
43 Analgesics Phase 4,Phase 2,Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
45 Analgesics, Opioid Phase 4
46 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
47 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
48 Antirheumatic Agents Phase 4,Phase 2,Phase 1
49 Cyclooxygenase 2 Inhibitors Phase 4
50 Cyclooxygenase Inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 300)

id Name Status NCT ID Phase Drugs
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
2 Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation Unknown status NCT00326729 Phase 4
3 Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation Unknown status NCT00885404 Phase 4 Lower chloride fluids (Hartmann's solution and Plasmalyte®)
4 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
5 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
6 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
7 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
8 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
9 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI) Completed NCT01481740 Phase 4 Phenylephrine bolus;phenylephrine infusion
10 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
11 Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
12 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
13 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
14 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
15 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
16 Effect of Prime Solution on Fluid Balance After Open Heart Surgery Completed NCT00797589 Phase 4 HES;Ringer lactate
17 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls. Completed NCT00291993 Phase 4
18 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
19 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
20 Arterial pH and Total Body Nitrogen Balances in APD Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
21 Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) Completed NCT00590044 Phase 4 insulin glargine+ glulisine;NPH + Regular insulin
22 Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment Completed NCT01099618 Phase 4 metformin;placebo;Sitagliptin
23 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
24 Preserve-Transplant Study Recruiting NCT03102996 Phase 4 Nephrotrans
25 Alkalinization by Urologists & Nephrologists Recruiting NCT03035812 Phase 4 Alkali
26 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Recruiting NCT01513655 Phase 4
27 Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluid During Renal Transplantation Recruiting NCT03115060 Phase 4 intravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE
28 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Recruiting NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
29 Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery Enrolling by invitation NCT02527811 Phase 4 Ulinastatin
30 Changes of Gas Values in Cord Blood Versus Time and Temperature Not yet recruiting NCT02785367 Phase 4
31 Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Not yet recruiting NCT03107208 Phase 4 Glargine
32 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
33 Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support Terminated NCT02414555 Phase 4 vasopressor;fluid bolus;Normal Saline;Elo-Mel Isoton (balanced acetat-based infusate)
34 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
35 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
36 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
37 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
38 D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) Completed NCT00143702 Phase 2, Phase 3 d4T;Abacavir;Riboflavin and Thiamine (Supplementation)
39 Balanced Salt Solution VS. Normal Saline Solution in Septic Shock Completed NCT02336620 Phase 3 Ringer acetate;Normal saline
40 FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study Completed NCT02612415 Phase 2, Phase 3
41 Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit Completed NCT02444988 Phase 3
42 Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG) Completed NCT02547779 Phase 3
43 Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Completed NCT00888290 Phase 2, Phase 3 Sodium bicarbonate
44 Evaluation of the Intubating Laryngeal Airway in Children Completed NCT01029431 Phase 3
45 The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients Completed NCT00529711 Phase 3 Hypertonic lactate;Ringer's lactate
46 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
47 Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m Completed NCT01835912 Phase 3
48 Pulmonary And Renal Support During Acute Respiratory Distress Syndrome Completed NCT01239966 Phase 3
49 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3
50 Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural Completed NCT00509405 Phase 3 potassium citrate

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Genetic tests related to Metabolic Acidosis:

id Genetic test Affiliating Genes
1 Metabolic Acidosis 29

Anatomical Context for Metabolic Acidosis

MalaCards organs/tissues related to Metabolic Acidosis:

39
Kidney, Heart, Bone, Brain, Lung, Liver, Testes

Publications for Metabolic Acidosis

Articles related to Metabolic Acidosis:

(show top 50) (show all 703)
id Title Authors Year
1
Topiramate and metabolic acidosis: an evolving story. ( 28828886 )
2017
2
The Relationship between Metabolic Acidosis and Nutritional Parameters in Patients on Hemodialysis. ( 28553038 )
2017
3
Hyperphosphatemia, a Cause of High Anion Gap Metabolic Acidosis: Report of a Case and Review of the Literature. ( 28450695 )
2017
4
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication. ( 28811944 )
2017
5
A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. ( 28924478 )
2017
6
Evaluation of the expected ventilatory response to metabolic acidosis in chronic hemodialysis patients. ( 28834137 )
2017
7
Hyperosmolar metabolic acidosis in burn patients exposed to glycol based topical antimicrobials-A systematic review. ( 28797572 )
2017
8
Raised Anion Gap Metabolic Acidosis in a 4-Day-Old Child. ( 28550127 )
2017
9
High Anion Gap Metabolic Acidosis ( 28846305 )
2017
10
Minding the Gap: Utility of the Anion Gap in the Differential Diagnosis of Metabolic Acidosis. ( 28764826 )
2017
11
Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality. ( 28565850 )
2017
12
Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap. ( 28599903 )
2017
13
Assessment of resuscitation as measured by markers of metabolic acidosis and features of injury. ( 28053267 )
2017
14
Impact of acute metabolic acidosis on the acid-base balance in follicular fluid and blood in dairy cattle. ( 28043369 )
2017
15
Chronic Diarrhea and Metabolic Acidosis Associated With Topiramate Use. ( 28885991 )
2017
16
Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts. ( 28934385 )
2017
17
High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. ( 28749752 )
2017
18
Preoperative metabolic acidosis in infants with gastroschisis. ( 28854513 )
2017
19
Metabolic Acidosis Stimulates the Production of the Antimicrobial Peptide Cathelicidin in Rabbit Urine. ( 28747361 )
2017
20
Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. ( 28782093 )
2017
21
Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. ( 28729033 )
2017
22
Topiramate induced metabolic acidosis and kidney stones - a case study. ( 28694730 )
2017
23
Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review. ( 28587067 )
2017
24
Congenital Microvillus Inclusion Disease in the Differential Diagnosis of Intractable Metabolic Acidosis. ( 27575604 )
2016
25
Metabolic Acidosis with Ophthalmic Dorzolamide in a Neonate. ( 27453705 )
2016
26
Starvation Ketoacidosis as a Cause of Unexplained Metabolic Acidosis in the Perioperative Period. ( 27752032 )
2016
27
A Quick Reference on High Anion Gap Metabolic Acidosis. ( 28017408 )
2016
28
(Uncommon) Mechanisms of Branchial Ammonia Excretion in the Common Carp (Cyprinus carpio) in Response to Environmentally Induced Metabolic Acidosis. ( 27082522 )
2016
29
The Author Reply: Endocrine and metabolic emergencies in children: hypocalcemia, hypoglycemia, adrenal insufficiency, and metabolic acidosis including diabetic ketoacidosis. ( 27462590 )
2016
30
Metabolic acidosis aggravates experimental acute kidney injury. ( 26773857 )
2016
31
Non-Anion Gap Metabolic Acidosis: A Clinical ApproachA toA Evaluation. ( 28029394 )
2016
32
Use of Lactated RingerA9s solution does not eliminate the risk of strong ion difference-related metabolic acidosis following on-pump cardiac surgery. ( 28078858 )
2016
33
A Rare Cause of Sudden Onset- Severe Metabolic Acidosis in Paediatric Surgical Patients- Organic Acidemia. ( 27134976 )
2016
34
ISMP Adverse Drug Reactions: Chronic Marijuana Use Associated With Recurrent Diabetic Ketoacidosis Lamotrigine-Induced Cataplexy Trimethoprim-Sulfamethoxazole-Induced Hyponatremia Ziprasidone-Induced Sleepwalking and Sleep-Related Eating Metabolic Acidosis Associated With Acetaminophen. ( 27928184 )
2016
35
Possible mechanisms of cardiac contractile dysfunction and electrical changes in ammonium chloride induced chronic metabolic acidosis in Wistar rats. ( 27539110 )
2016
36
Severe Metabolic Acidosis and Hepatopathy due to Leukoencephalopathy with Thalamus and Brainstem Involvement and High Lactate. ( 27875839 )
2016
37
Metabolic Acidosis Assessment in High-Risk Surgeries: Prognostic Importance. ( 27644062 )
2016
38
Novel ECHS1 mutation in an Emirati neonate with severe metabolic acidosis. ( 27221955 )
2016
39
Sodium-Glucose Cotransporter 2 Inhibitors and Euglycemic Diabetic Ketoacidosis: Metabolic Acidosis With a Twist. ( 27766015 )
2016
40
Metabolic Acidosis and Long-Term Clinical Outcomes in Kidney Transplant Recipients. ( 28031407 )
2016
41
Late Metabolic Acidosis Caused by Renal Tubular Acidosis in Acute Salicylate Poisoning. ( 27181539 )
2016
42
JK Muraskas in response to the article by C.A Racinet et al. Neonatal metabolic acidosis at birth: In search of a reliable marker. Gynecol Obstet Fertil 2016; 44: 357-62. ( 27426689 )
2016
43
Is STAN monitoring associated with a significant decrease in metabolic acidosis at birth compared with cardiotocography alone? Review of the three meta-analyses that included the recent US trial. ( 27199086 )
2016
44
Effects of sodium hydroxide treatment of dried distillers' grains on digestibility, ruminal metabolism, and metabolic acidosis of feedlot steers. ( 27065141 )
2016
45
A man with altered mental status and metabolic acidosis. ( 27126444 )
2016
46
Belittling of a significant decline in neonatal metabolic acidosis rate achieved by STAN monitoring. ( 26840478 )
2016
47
Nitazoxanide induces inA vitro metabolic acidosis in Taenia crassiceps cysticerci. ( 27751770 )
2016
48
Role of proton receptor OGR1 in bone response to metabolic acidosis? ( 26880446 )
2016
49
Approach to the Treatment of Chronic Metabolic Acidosis in CKD. ( 26776539 )
2016
50
A 3-Month-Old Infant With Lethargy and Metabolic Acidosis. ( 27609511 )
2016

Variations for Metabolic Acidosis

Expression for Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for Metabolic Acidosis

Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 ALB ATP6V0A4 ATP6V1B1 BTD CA2 FBP1
2
Show member pathways
12.94 ALB AQP2 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4
3 12.2 AQP2 CA2 FBP1 SLC4A4
4
Show member pathways
12.15 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
5 11.53 CA2 SLC4A4 SLC9A1
6 11.11 CA2 SLC4A4 SLC9A1 SLC9A3
7 10.29 CA2 GLS2 SLC4A4 SLC9A3
8 9.8 BTD HLCS

GO Terms for Metabolic Acidosis

Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 ALB AQP2 ATP6V0A4 ATP6V1B1 BTD CA2
2 mitochondrial matrix GO:0005759 9.62 BTD GLS2 HMGCL MLYCD
3 apical plasma membrane GO:0016324 9.55 AQP2 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
4 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V0A4 ATP6V1B1
5 basolateral plasma membrane GO:0016323 9.1 AQP2 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A1

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.72 SLC4A4 SLC9A1 SLC9A3
2 ion transport GO:0006811 9.7 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4 SLC9A1 SLC9A3
3 ossification GO:0001503 9.65 ATP6V0A4 ATP6V1B1 BGLAP
4 phagosome acidification GO:0090383 9.58 ATP6V0A4 ATP6V1B1
5 bicarbonate transport GO:0015701 9.58 CA2 SLC4A1 SLC4A4
6 ATP hydrolysis coupled proton transport GO:0015991 9.57 ATP6V0A4 ATP6V1B1
7 inorganic anion transport GO:0015698 9.56 SLC4A1 SLC4A4
8 anion transport GO:0006820 9.54 SLC4A1 SLC4A4
9 sodium ion import across plasma membrane GO:0098719 9.52 SLC9A1 SLC9A3
10 excretion GO:0007588 9.5 AQP2 ATP6V0A4 ATP6V1B1
11 sodium ion transmembrane transport GO:0035725 9.49 SLC4A4 SLC9A1
12 biotin metabolic process GO:0006768 9.46 BTD HLCS
13 ion homeostasis GO:0050801 9.43 KLHL3 WNK4
14 renal sodium ion absorption GO:0070294 9.37 KLHL3 WNK4
15 distal tubule morphogenesis GO:0072156 9.26 KLHL3 WNK4
16 regulation of pH GO:0006885 9.26 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
17 regulation of intracellular pH GO:0051453 9.02 CA2 SLC4A1 SLC4A4 SLC9A1 SLC9A3
18 transport GO:0006810 10.11 ALB AQP2 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 9.58 CA2 HMGCL MLYCD
2 inorganic anion exchanger activity GO:0005452 9.37 SLC4A1 SLC4A4
3 anion transmembrane transporter activity GO:0008509 9.32 SLC4A1 SLC4A4
4 solute:proton antiporter activity GO:0015299 9.26 SLC9A1 SLC9A3
5 sodium:proton antiporter activity GO:0015385 9.16 SLC9A1 SLC9A3
6 potassium:proton antiporter activity GO:0015386 8.96 SLC9A1 SLC9A3
7 sodium:bicarbonate symporter activity GO:0008510 8.32 SLC4A4

Sources for Metabolic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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