MCID: MTB004
MIFTS: 49

Metabolic Acidosis

Categories: Metabolic diseases

Aliases & Classifications for Metabolic Acidosis

MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 72 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050758
UMLS 69 C0220981

Summaries for Metabolic Acidosis

Disease Ontology : 12 A lactic acidosis that has material basis in high levels of acid.

MalaCards based summary : Metabolic Acidosis is related to renal tubular acidosis, distal and renal tubular acidosis, distal, autosomal recessive. An important gene associated with Metabolic Acidosis is HMGCL (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 72 Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or... more...

Related Diseases for Metabolic Acidosis

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 renal tubular acidosis, distal 32.1 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
2 renal tubular acidosis, distal, autosomal recessive 31.5 ATP6V0A4 ATP6V1B1 SLC4A1
3 renal tubular acidosis 30.9 ATP6V0A4 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A3
4 medullary sponge kidney 29.7 ATP6V0A4 ATP6V1B1
5 propionic acidemia 29.3 HLCS HMGCL MLYCD
6 ovarian dysgenesis, hypergonadotropic, with short stature and recurrent metabolic acidosis 12.1
7 fructose-1,6-bisphosphatase deficiency 11.4
8 glutathione synthetase deficiency 11.4
9 carbonic anhydrase va deficiency, hyperammonemia due to 11.3
10 lactic acidosis 11.1
11 renal tubular acidosis, distal, autosomal dominant 11.0
12 multiple acyl-coa dehydrogenase deficiency 11.0
13 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.0
14 malonyl-coa decarboxylase deficiency 11.0
15 renal tubular acidosis, distal, with progressive nerve deafness 11.0
16 hawkinsinuria 11.0
17 malignant hyperthermia 1 11.0
18 d-glyceric aciduria 11.0
19 3-methylglutaconic aciduria, type i 11.0
20 fumarase deficiency 11.0
21 mitochondrial trifunctional protein deficiency 11.0
22 mitochondrial complex i deficiency due to acad9 deficiency 11.0
23 renal tubular acidosis, distal, with hemolytic anemia 11.0
24 pseudohypoaldosteronism, type iid 11.0
25 pseudohypoaldosteronism, type iie 11.0
26 pseudohypoaldosteronism, type iia 10.8
27 alpha-ketoglutarate dehydrogenase deficiency 10.8
28 leigh syndrome, french canadian type 10.8
29 hydroxykynureninuria 10.8
30 isovaleric acidemia 10.8
31 methylmalonyl-coa epimerase deficiency 10.8
32 mitochondrial myopathy with lactic acidosis 10.8
33 holocarboxylase synthetase deficiency 10.8
34 mitochondrial dna depletion syndrome 6 10.8
35 pseudohypoaldosteronism, type i, autosomal recessive 10.8
36 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 10.8
37 hsd10 mitochondrial disease 10.8
38 carnitine palmitoyltransferase ii deficiency, infantile 10.8
39 nephronophthisis 2 10.8
40 combined oxidative phosphorylation deficiency 2 10.8
41 combined oxidative phosphorylation deficiency 3 10.8
42 combined oxidative phosphorylation deficiency 5 10.8
43 pseudohypoaldosteronism, type iib 10.8
44 pseudohypoaldosteronism, type iic 10.8
45 mitochondrial pyruvate carrier deficiency 10.8
46 riboflavin deficiency 10.8
47 sudden cardiac failure, infantile 10.8
48 2-methyl-3-hydroxybutyric aciduria 10.8
49 autosomal dominant tubulointerstitial kidney disease 10.8
50 slc4a1-associated distal renal tubular acidosis 10.8

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis

Symptoms & Phenotypes for Metabolic Acidosis

MGI Mouse Phenotypes related to Metabolic Acidosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2 HMGCL
2 renal/urinary system MP:0005367 9.28 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2 SLC4A1

Drugs & Therapeutics for Metabolic Acidosis

Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 312)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 4091 14219
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3 Parecoxib Approved Phase 4 198470-84-7
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8 Racepinephrine Approved Phase 4 329-65-7
9
Insulin Glargine Approved Phase 4 160337-95-1
10
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
11
Ephedrine Approved Phase 4,Phase 2,Phase 3 299-42-3 9294
12
Oxymetazoline Approved, Investigational Phase 4,Phase 2,Phase 3 1491-59-4 4636
13
Phenylephrine Approved Phase 4,Phase 2,Phase 3 59-42-7 6041
14
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3 90-82-4 7028
15
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
16
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
17
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
18
Insulin-glulisine Approved Phase 4 207748-29-6
19
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 32051 23994
20
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
21
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
22
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
23
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
24
Amphotericin B Approved, Investigational Phase 4 1397-89-3 5280965 14956
25
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
26
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
28
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8 1130
29
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
30
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 77-92-9 311
31
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
32 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
33 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
34 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
35 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
36 Ophthalmic Solutions Phase 4,Phase 3
37 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
38 Plasma-lyte 148 Phase 4,Phase 3
39 Antipsychotic Agents Phase 4
40 Central Nervous System Depressants Phase 4,Phase 1
41 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
42 Psychotropic Drugs Phase 4
43 Tranquilizing Agents Phase 4
44 Analgesics Phase 4,Phase 2,Phase 1
45 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
46 Analgesics, Opioid Phase 4
47 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
49 Antirheumatic Agents Phase 4,Phase 2,Phase 1
50 Cyclooxygenase 2 Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 313)

# Name Status NCT ID Phase Drugs
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
2 Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation Unknown status NCT00885404 Phase 4 Lower chloride fluids (Hartmann's solution and Plasmalyte®)
3 Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation Unknown status NCT00326729 Phase 4
4 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
5 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
6 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
7 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
8 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
9 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI) Completed NCT01481740 Phase 4 Phenylephrine bolus;phenylephrine infusion
10 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
11 Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
12 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
13 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
14 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
15 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
16 Effect of Prime Solution on Fluid Balance After Open Heart Surgery Completed NCT00797589 Phase 4 HES;Ringer lactate
17 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls. Completed NCT00291993 Phase 4
18 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
19 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
20 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
21 Arterial pH and Total Body Nitrogen Balances in APD Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
22 Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) Completed NCT00590044 Phase 4 insulin glargine+ glulisine;NPH + Regular insulin
23 Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment Completed NCT01099618 Phase 4 metformin;placebo;Sitagliptin
24 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
25 Preserve-Transplant Study Recruiting NCT03102996 Phase 4 Nephrotrans
26 Alkalinization by Urologists & Nephrologists Recruiting NCT03035812 Phase 4 Alkali
27 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Recruiting NCT01513655 Phase 4
28 Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluid During Renal Transplantation Recruiting NCT03115060 Phase 4 intravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE
29 Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Recruiting NCT03107208 Phase 4 Glargine
30 Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery Enrolling by invitation NCT02527811 Phase 4 Ulinastatin
31 Changes of Gas Values in Cord Blood Versus Time and Temperature Not yet recruiting NCT02785367 Phase 4
32 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
33 Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support Terminated NCT02414555 Phase 4 vasopressor;fluid bolus;Normal Saline;Elo-Mel Isoton (balanced acetat-based infusate)
34 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
35 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
36 Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD) Unknown status NCT01640119 Phase 3
37 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
38 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
39 D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) Completed NCT00143702 Phase 2, Phase 3 d4T;Abacavir;Riboflavin and Thiamine (Supplementation)
40 Balanced Salt Solution VS. Normal Saline Solution in Septic Shock Completed NCT02336620 Phase 3 Ringer acetate;Normal saline
41 FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study Completed NCT02612415 Phase 2, Phase 3
42 Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG) Completed NCT02547779 Phase 3
43 Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit Completed NCT02444988 Phase 3
44 Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Completed NCT00888290 Phase 2, Phase 3 Sodium bicarbonate
45 Evaluation of the Intubating Laryngeal Airway in Children Completed NCT01029431 Phase 3
46 The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients Completed NCT00529711 Phase 3 Hypertonic lactate;Ringer's lactate
47 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
48 Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m Completed NCT01835912 Phase 3
49 Pulmonary And Renal Support During Acute Respiratory Distress Syndrome Completed NCT01239966 Phase 3
50 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Genetic tests related to Metabolic Acidosis:

# Genetic test Affiliating Genes
1 Metabolic Acidosis 28

Anatomical Context for Metabolic Acidosis

MalaCards organs/tissues related to Metabolic Acidosis:

38
Kidney, Heart, Bone, Brain, Lung, Liver, Testes

Publications for Metabolic Acidosis

Articles related to Metabolic Acidosis:

(show top 50) (show all 721)
# Title Authors Year
1
Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD. ( 29030467 )
2018
2
The problem of using standardised base excess as a measure of metabolic acidosis. ( 29430996 )
2018
3
Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. ( 29333622 )
2018
4
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
5
New Frontiers in Treating Uremic Metabolic Acidosis. ( 29102960 )
2018
6
In silico identification of genes involved in chronic metabolic acidosis. ( 29138116 )
2018
7
High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. ( 28749752 )
2017
8
A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. ( 28924478 )
2017
9
Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap. ( 28599903 )
2017
10
Chronic Diarrhea and Metabolic Acidosis Associated With Topiramate Use. ( 28885991 )
2017
11
Assessment of resuscitation as measured by markers of metabolic acidosis and features of injury. ( 28053267 )
2017
12
Management of the Metabolic Acidosis of Chronic Kidney Disease. ( 29031356 )
2017
13
Lentiform fork sign due to severe metabolic acidosis. ( 29212873 )
2017
14
Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. ( 28729033 )
2017
15
Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts. ( 28934385 )
2017
16
Topiramate induced metabolic acidosis and kidney stones - a case study. ( 28694730 )
2017
17
High anion gap metabolic acidosis: A case of pyroglutamic acidosis. ( 29044962 )
2017
18
Metabolic acidosis in hemodialysis patients: a review. ( 29044339 )
2017
19
Raised Anion Gap Metabolic Acidosis in a 4-Day-Old Child. ( 28550127 )
2017
20
Minding the Gap: Utility of the Anion Gap in the Differential Diagnosis of Metabolic Acidosis. ( 28764826 )
2017
21
Evaluation of the expected ventilatory response to metabolic acidosis in chronic hemodialysis patients. ( 28834137 )
2017
22
Urine Ammonium, Metabolic Acidosis and Progression of Chronic Kidney Disease. ( 29050011 )
2017
23
Topiramate and metabolic acidosis: an evolving story. ( 28828886 )
2017
24
Adverse Effects of the Metabolic Acidosis of Chronic Kidney Disease. ( 29031355 )
2017
25
Hyperphosphatemia, a Cause of High Anion Gap Metabolic Acidosis: Report of a Case and Review of the Literature. ( 28450695 )
2017
26
Hyperosmolar metabolic acidosis in burn patients exposed to glycol based topical antimicrobials-A systematic review. ( 28797572 )
2017
27
Alkaline Diet and Metabolic Acidosis: Practical Approaches to the Nutritional Management of Chronic Kidney Disease. ( 29221627 )
2017
28
Early optimal parenteral nutrition and metabolic acidosis in very preterm infants. ( 29176758 )
2017
29
Impact of acute metabolic acidosis on the acid-base balance in follicular fluid and blood in dairy cattle. ( 28043369 )
2017
30
Determinants and Outcome of Metabolic Acidosis in Diarrheal Children Under 5 Years of Age in an Urban Critical Care Ward in Bangladesh. ( 29152544 )
2017
31
Metabolic Acidosis Stimulates the Production of the Antimicrobial Peptide Cathelicidin in Rabbit Urine. ( 28747361 )
2017
32
Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review. ( 28587067 )
2017
33
High Anion Gap Metabolic Acidosis ( 28846305 )
2017
34
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication. ( 28811944 )
2017
35
Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. ( 28782093 )
2017
36
Fructose-1,6-bisphosphatase deficiency as aA cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients. ( 29203193 )
2017
37
The Relationship between Metabolic Acidosis and Nutritional Parameters in Patients on Hemodialysis. ( 28553038 )
2017
38
Preoperative metabolic acidosis in infants with gastroschisis. ( 28854513 )
2017
39
Review of the Diagnostic Evaluation of Normal Anion Gap Metabolic Acidosis. ( 29344509 )
2017
40
Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality. ( 28565850 )
2017
41
Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe? ( 29381982 )
2017
42
Perinatal inflammation/infection and its association with correction of metabolic acidosis in hypoxic-ischemic encephalopathy. ( 26796123 )
2016
43
Neonatal metabolic acidosis at birth: In search of a reliable marker. ( 27216950 )
2016
44
Hypokalemia during acute metabolic acidosis on hemodilution with succinylated gelatin in rats. ( 28032570 )
2016
45
Non-Anion Gap Metabolic Acidosis: A Clinical ApproachA toA Evaluation. ( 28029394 )
2016
46
ISMP Adverse Drug Reactions: Chronic Marijuana Use Associated With Recurrent Diabetic Ketoacidosis Lamotrigine-Induced Cataplexy Trimethoprim-Sulfamethoxazole-Induced Hyponatremia Ziprasidone-Induced Sleepwalking and Sleep-Related Eating Metabolic Acidosis Associated With Acetaminophen. ( 27928184 )
2016
47
A Quick Reference on Hyperchloremic Metabolic Acidosis. ( 28017409 )
2016
48
Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous veno-venous hemofiltration. ( 27562561 )
2016
49
Starvation Ketoacidosis as a Cause of Unexplained Metabolic Acidosis in the Perioperative Period. ( 27752032 )
2016
50
Hyperglycemic, high anion-gap metabolic acidosis in patients receiving SGLT-2 inhibitors for diabetes management. ( 27913012 )
2016

Variations for Metabolic Acidosis

Expression for Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for Metabolic Acidosis

Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 ALB ATP6V0A4 ATP6V1B1 CA2 FBP1 GLS2
2
Show member pathways
12.94 ALB AQP2 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4
3 12.22 AQP2 CA2 FBP1 SLC4A4
4
Show member pathways
12.15 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
5 11.53 CA2 SLC4A4 SLC9A1
6 11.46 GSS HMGCL OGDH
7 11.11 CA2 SLC4A4 SLC9A1 SLC9A3
8 10.29 CA2 GLS2 SLC4A4 SLC9A3

GO Terms for Metabolic Acidosis

Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2 FBP1
2 mitochondrial matrix GO:0005759 9.62 GLS2 HMGCL MLYCD OGDH
3 apical plasma membrane GO:0016324 9.55 AQP2 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
4 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V0A4 ATP6V1B1
5 basolateral plasma membrane GO:0016323 9.1 AQP2 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A1

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.7 SLC4A4 SLC9A1 SLC9A3
2 ion transport GO:0006811 9.7 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4 SLC9A1 SLC9A3
3 ossification GO:0001503 9.65 ATP6V0A4 ATP6V1B1 BGLAP
4 sodium ion transmembrane transport GO:0035725 9.63 SLC4A1 SLC4A4 SLC9A1
5 bicarbonate transport GO:0015701 9.58 CA2 SLC4A1 SLC4A4
6 phagosome acidification GO:0090383 9.56 ATP6V0A4 ATP6V1B1
7 ATP hydrolysis coupled proton transport GO:0015991 9.55 ATP6V0A4 ATP6V1B1
8 inorganic anion transport GO:0015698 9.54 SLC4A1 SLC4A4
9 anion transport GO:0006820 9.51 SLC4A1 SLC4A4
10 excretion GO:0007588 9.5 AQP2 ATP6V0A4 ATP6V1B1
11 sodium ion import across plasma membrane GO:0098719 9.49 SLC9A1 SLC9A3
12 ion homeostasis GO:0050801 9.43 KLHL3 WNK4
13 renal sodium ion absorption GO:0070294 9.37 KLHL3 WNK4
14 distal tubule morphogenesis GO:0072156 9.26 KLHL3 WNK4
15 regulation of pH GO:0006885 9.26 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
16 regulation of intracellular pH GO:0051453 9.02 CA2 SLC4A1 SLC4A4 SLC9A1 SLC9A3

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inorganic anion exchanger activity GO:0005452 9.37 SLC4A1 SLC4A4
2 anion transmembrane transporter activity GO:0008509 9.32 SLC4A1 SLC4A4
3 solute:proton antiporter activity GO:0015299 9.26 SLC9A1 SLC9A3
4 sodium:proton antiporter activity GO:0015385 9.16 SLC9A1 SLC9A3
5 potassium:proton antiporter activity GO:0015386 8.96 SLC9A1 SLC9A3
6 sodium:bicarbonate symporter activity GO:0008510 8.62 SLC4A1 SLC4A4

Sources for Metabolic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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