Metabolic Disorders malady

MedlinePlus: Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood sugar levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Metabolic Disorders, also known as metabolic syndrome x, is related to metabolic syndrome x and lipid metabolism disorder. An important gene associated with Metabolic Disorders is G6PC (glucose-6-phosphatase, catalytic subunit), and among its related pathways are Metabolic pathways and PPAR signaling pathway. The drugs magnesium hydroxide and milk of magnesia [va product] and the compounds atp and lactate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia: Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of...⁴⁴ more...

metabolic disorders 44 17 23 metabolic syndrome x 43 metabolic syndrome 23

metabolic disorder 32 metabolic diseases 43

Disease types for metabolic disorders family:

metabolic syndrome x

Diseases related to metabolic disorders by text searches and GeneDecks gene sharing:

(show top 50)    (show all 978)

id	Related Disease	Score	Top Affiliating Genes
1	metabolic syndrome x	35.7	SERPINE1, LPL, LEP, INS, INSR, IL6
2	lipid metabolism disorder	33.9	LPL, INS, APOA1, APOB, HLA-G, ACAT1
3	alcoholism	32.9	CNR1, ARSA, GPT, ALDH1A1, ALDH2, ALDH9A1
4	carbohydrate metabolic disorder	32.9	IRS1, IRS2, INS, HP, PPARG, PPARA
5	obesity	32.2	UCP1, GHRL, ADRB2, ADRB3
6	morbid obesity	31.8	RETN, GCG, LPL, LEP, LEPR, INS
7	insulin resistance	31.7	LEPR, UCP2, IRS1, INS, PTPN1, PPARGC1A
8	sleep apnea	31.7	RETN, LEP, GHR, NPY, ADRB2, ADIPOQ
9	familial combined hyperlipidemia	31.5	LPL, USF1, LEPR, LDLR, LCAT, CETP
10	gestational diabetes	31.5	RETN, GCK, GCG, NAMPT, LEP, LEPR
11	purine-pyrimidine metabolic disorder	31.4	APRT, DPYD, ADSL
12	retinol binding protein	31.3	RETN, PCK2, NAMPT, LEP, XDH, B2M
13	lysosomal storage disease	31.3	CHIT1, ARSA, IDUA, GLA, CTNS, CTSA
14	breast cancer	30.7	NCOA1, LDLR, IRS1, IRS2, FASN, GHR
15	organic acidemia	30.3	PC, BTD, HLCS
16	galactosemia	30.2	BTD, AKR1B1, OTC, ACADM, G6PD, SLC2A2
17	gaucher's disease	30.2	BGLAP, CHIT1, ARSA, IDUA, GLA, SMPD1
18	bilirubin metabolic disorder	30.0	GPT, ALB, HP, NR1I3, G6PD, GGT1
19	multiple carboxylase deficiency	30.0	PC, BTD, HMGCL, OTC, ACADM, HLCS
20	iron metabolism disease	29.6	CRP, G6PD, HFE, TTR, TF, CP
21	hypogonadism	29.4	RETN, SERPINE1, VDR, LMNA, BGLAP, LEP
22	vascular disease	29.1	LRP1, RETN, VWF, SELP, SERPINE1, NAMPT
23	hypertriglyceridemia	29.1	LRP1, SELP, SERPINE1, NAMPT, LPL, LMNA
24	aldosteronism	29.0	KL, RETN, GCH1, SERPINE1, NAMPT, UCP1
25	mucopolysaccharidosis	29.0	LCAT, ARSA, APRT, IDUA, GLA, HEXA
26	cholesterol	29.0	LRP1, KL, NCOA1, RETN, CNR1, VWF
27	lactic acidosis	28.9	PC, BTD, AUH, GSTZ1, PDHA1, NDUFS4
28	familial hypercholesterolemia	28.9	LPL, LDLR, LCAT, CETP, APOA1, APOB
29	tyrosinemia	28.8	BTD, PAH, GSTZ1, FAH, HPD, PTS
30	nephrolithiasis	28.8	VDR, BGLAP, XDH, B2M, INS, FGF23
31	congenital disorder of glycosylation	28.8	VWF, ALB, HP, AGA, TF, PMM2
32	developmental disabilities	28.7	LMNA, ETFDH, HPRT1, GK, HNF4A, G6PC
33	homocystinuria	28.7	BTD, LMBRD1, MUT, ALB, CBS, HMGCL
34	reye syndrome	28.7	PC, ASS1, GPT, ETFDH, HMGCL, OTC
35	mucolipidosis	28.7	LCAT, ARSA, CASR, SMPD1, HEXA, NPC1
36	type 1 diabetes mellitus	28.6	RETN, GCK, GCG, VDR, BGLAP, BCHE
37	familial hyperlipidemia	28.5	LPL, USF1, LDLR, LCAT, CETP, INS
38	eating disorder	28.5	RETN, CNR1, LEP, LEPR, GHRL, DPP4
39	acanthosis nigricans	28.4	LMNA, LEP, INS, INSR, IGF1, GH1
40	schizophrenia	28.4	CNR1, PCK1, GCH1, LPL, VDR, PAH
41	familial hypertriglyceridemia	28.3	LPL, USF1, APOA1, APOB, APOE
42	krabbe disease	28.3	CHIT1, ARSA, MBP, HEXA, PRKAB1
43	glucose intolerance	28.3	GCG, APOB, GHRL, CYP7A1, SLC2A2, CP
44	glycogen storage disease iv	28.3	G6PC, CPT2, GBE1, GAA
45	adenosine deaminase deficiency	28.3	OTC, PNP, AHCY, ADK, ADA, GBA
46	urea cycle disorder	28.3	NAGS, ASS1, OTC, SLC25A13
47	purine nucleoside phosphorylase deficiency	28.3	APRT, HPRT1, PNP, AHCY, ADK, ADA
48	alkaptonuria	28.3	GSTZ1, FAH, HGD
49	ornithine carbamoyltransferase deficiency	28.3	ASS1, HMGCL, OTC, CPS1
50	hyperuricemia	28.3	GCK, SELP, SERPINE1, LPL, LEP, XDH

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 magnesium hydroxide, milk of magnesia [va product]

Cell-based therapeutics:

MalaCards organs/tissues related to metabolic disorders:

²²

MGI Mouse Phenotypes related to metabolic disorders:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	LRP1, KL, NCOA1, RETN, CNR1, VWF
2	liver/biliary system phenotype	MP:0005370	11.2	RETN, PCCA, PCK1, GCK, LPL, UROD
3	integument phenotype	MP:0010771	11.2	KL, NCOA1, CNR1, PCCA, PCK1, BTD
4	renal/urinary system phenotype	MP:0005367	11.0	KL, NCOA1, PCCA, GCK, GCDH, BTD
5	pigmentation phenotype	MP:0001186	10.5	BTD, LMNA, PAH, LEP, LDLR, ATP7B
6	endocrine/exocrine gland phenotype	MP:0005379	10.4	KL, NCOA1, LDLR, XDH, GPR119, ALDH1A1
7	other phenotype	MP:0005395	10.1	KL, CNR1, LEPR, LDLR, ATP7B, APOE
8	skeleton phenotype	MP:0005390	10.0	LRP1, NCOA1, CNR1, VDR, LMNA, UROS
9	nervous system phenotype	MP:0003631	9.7	LRP1, KL, NCOA1, CNR1, VWF, GCDH
10	limbs/digits/tail phenotype	MP:0005371	9.7	KL, VDR, LMNA, SCD, LEP, CHKB
11	hearing/vestibular/ear phenotype	MP:0005377	8.7	VDR, LMNA, ATP8B1, ASS1, IRS1, ARSA
12	cellular phenotype	MP:0005384	8.7	KL, CNR1, VWF, SELP, NAMPT, VDR
13	behavior/neurological phenotype	MP:0005386	8.7	LRP1, KL, NCOA1, CNR1, PCCA, PCK1
14	adipose tissue phenotype	MP:0005375	8.6	LRP1, KL, RETN, CNR1, PCK1, SERPINE1
15	muscle phenotype	MP:0005369	8.5	LRP1, KL, BTD, LPL, LMNA, LEP
16	vision/eye phenotype	MP:0005391	8.1	BTD, SELP, LMNA, PAH, LEP, LEPR
17	digestive/alimentary phenotype	MP:0005381	7.9	KL, VWF, GCG, VDR, LMNA, LEP
18	mortality/aging	MP:0010768	INF	LRP1, KL, CNR1, VWF, PCCA, PCK1
19	respiratory system phenotype	MP:0005388	INF	KL, SELP, LPL, LEPR, , MUT
20	tumorigenesis	MP:0002006	INF	SERPINE1, LEP, LEPR, , B2M, MMP2
21	reproductive system phenotype	MP:0005389	INF	NCOA1, VDR, LMNA, PAH, , LEP
22	cardiovascular system phenotype	MP:0005385	INF	LRP1, KL, VWF, SELP, SERPINE1, LPL
23	immune system phenotype	MP:0005387	INF	LRP1, KL, NCOA1, VWF, SELP, VDR
24	growth/size phenotype	MP:0005378	INF	LRP1, KL, NCOA1, CNR1, PCK1, GCK
25	hematopoietic system phenotype	MP:0005397	INF	UROS, , ATP7B, ARSA, GSTZ1, FGF23
26	normal phenotype	MP:0002873	INF	LRP1, NCOA1, PCK1, LMNA, USF1, UROD

Articles related to metabolic disorders:

(show top 50)    (show all 129)

id	Title	Authors	Year	Affiliating Genes
1	Human C-reactive protein exacerbates metabolic disord ers in association with adipose tissue remodelling. (21447704)	Kaneko H.... Fukuda K.	2011	CRP
2	Design and validation of a metabolic disorder reseque ncing microarray (BRUM1). (20578233)	Bruce C.K.... Gissen P.	2010	VIPAS39
3	Diagnosis of creatine metabolism disorders by determi ning creatine and guanidinoacetate in plasma and urine. (20077070)	Sun Q.... O'Brien W.E.	2010	GAMT, GATM
4	Body mass index as an indicator of metabolic disorder s in annual health checkups among Japanese male workers. (19996536)	Ohwaki K.... Yano E.	2009	GPT
5	Link between insulin and metabolic disorders in cance r: does leptin play a key role? (18561022)	Malandrino N.... Capristo E.	2009	LEP
6	CIDE proteins and metabolic disorders. (19276890)	Gong J.... Li P.	2009	CIDEC
7	TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders. (19429513)	Tiwari A.... Maiti P.	2009	NR1H4
8	Bilateral cataract in childhood years: always an indication for screening on a metabolic disorder (18410025)	Wijburg M.T.... Bams-Mengerink A.	2008	GALK1
9	From integrative signalling to metabolic disorders. (18468884)	Otis M.... Gallo-Payet N.	2008	DHCR24
10	Diagnosis of metabolic disorders in women with polycystic ovary syndrome. (19017415)	Angioni S.... Fulghesu A.M.	2008	INS
11	Adaptations to climate in candidate genes for common metabolic disorders. (18282109)	Hancock A.M.... Di Rienzo A.	2008	LEPR, FABP2
12	Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non-Hodgkin lymphoma (NHL). (18429947)	Steffens M.... Maiter D.	2008	INS
13	Biomarker candidates for cardiovascular disease and bone metabolism disorders in chronic kidney disease: a systems biology perspective. (18266955)	Perco P.... Oberbauer R.	2008	COL20A1
14	Association of free fatty acids (FFA) and tumor necrosis factor-alpha (TNF-alpha) and insulin-resistant metabolic disorder. (17373637)	Ohmura E.... Sato T.	2007	TNF, ADIPOQ
15	The cost-effectiveness of expanding newborn screening for up to 21 inherited metabolic disorders using tandem mass spectrometry: results from a decision-analytic model. (17391418)	Cipriano L.E.... Zaric G.S.	2007	HMGCL
16	Screening for tetrahydrobiopterin metabolic disorders and related gene analysis among the patients with motor disturbance and mental retardation (17407085)	Ye J.... Gu X.F.	2007	GCH1, PAH, PTS
17	Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. (17608855)	Fan J.G.... Gao Y.	2007	GPT
18	Targeting farnesoid X receptor for liver and metabolic disorders. (17588816)	Fiorucci S.... Santucci L.	2007	NR1H4, NR1I2, NR1I3
19	GHR exon 3 polymorphism: association with type 2 diabetes mellitus and metabolic disorder. (17537658)	Strawbridge R.J.... Brismar K.	2007	IGF1, GHR, CRP
20	Impact of interleukin 6 -174G>C polymorphism on obesity-related metabolic disorders in people with excess in body weight. (17998015)	Goyenechea E.... Martinez J.A.	2007	IL6, INS
21	Insulin resistance in Brazilian adolescent girls: association with overweight and metabolic disorders. (16621110)	Alvarez M.M.... da Veiga G.V.	2006	INS
22	Plasma levels of vWF and NO in patients with metabolic syndrome and their relationship with metabolic disorders (16764036)	Sun Y.X.... Zhang Z.J.	2006	VWF
23	Metabolic disorders in children and adolescents with type 2 diabetes mellitus. (17180786)	Huang C.Y.... Lee Y.J.	2006	INS
24	Hepatitic inherited metabolic disorders. (17355091)	Arroyo M.... Crawford J.M.	2006	ATP8B1
25	Glucose metabolic disorders in relation with insulin resistance in pediatric age (15799852)	Herrera M.T.... Barrio R.	2005	INS
26	The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology (16018179)	Vynohradova S.V.	2005	ACE
27	Adiponectin--common link in the pathogenesis of metabolic disorders and cardiovascular diseases? (15962618)	Michalewska-WA8udarczyk A.... Tendera M.	2004	ADIPOQ
28	Estimation of the severity of metabolic disorders in children with newly diagnosed insulin dependent diabetes mellitus (IDDM) (12878797)	Charemska D.... Klonowska B.	2003	INS
29	Interconnection between insulin resistance and lipid metabolism disorders in obese patients (12469622)	Ageeva V.V.... Shliakhto E.V.	2002	INS
30	Fibrinolysis defect in long-term hemodialysis patients with type 2 diabetes mellitus and its relation to metabolic disorders. (12381940)	OpatrnA1 K.... Massry S.G.	2002	PLAT, SERPINE1, APOA1
31	Simple non-radiochemical HPLC-linked method for screening for purine metabolism disorders using dried blood spot. (12204435)	Jacomelli G.... Pompucci G.	2002	ADA, HPRT1, APRT
32	Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids (11925670)	Vondra K.... Zamrazil V.	2002	IGF1, IGFBP3, GH1
33	Diagnostic criteria of carbohydrate metabolism disorders in pulmonary tuberculosis complicated by diabetes mellitus in patients with various haptoglobin phenotypes (11338533)	Parpieva N.N.... Kazakov K.S.	2001	HP
34	Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. (11641236)	Sesti G.... Lauro R.	2001	INSR, IRS1, IRS2
35	Inherited metabolic disorders in Thailand--Siriraj experience. (11400749)	Wasant P.... Matsumoto I.	1999	NEU1
36	Urinary excretion of aquaporin-2 in water metabolism disorders (10375960)	Ishikawa S.... Saito T.	1999	AQP2
37	Beta-3 adrenergic receptor--structure and role in obesity and metabolic disorders (10645145)	Wiejak J.... Wyroba E.	1999	ADRB3, UCP1
38	Somatomedin-1 (recombinant insulin-like growth factor-1): clinical pharmacology and potential treatment of endocrine and metabolic disorders. (18031115)	Laron Z.	1999	IGF1
39	Metabolic disorders in digestive and hepatobiliary pathology in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station (10050454)	Shkala L.V.	1998	GPT
40	Pharmacologic treatment of lipid metabolism disorders (9214849)	Gminski J.	1996	ACAT1
41	Syndrome X. Recognition and management of this metabolic disorder in primary care. (8784876)	Minchoff L.E.... Grandin J.A.	1996	INS
42	Reproductive effects of maternal metabolic disorders: implications for pediatrics and obstetrics. (8827903)	Levy H.L.	1996	HADHA, OTC
43	The treatment of hypertension in patients with a metabolic disorder (8562259)	Dal PalA^ C.... Semplicini A.	1995	INS
44	Carbohydrate metabolic disorder in women with a neuroendocrine syndrome (8017575)	Khrennikova O.V.... Khrennikov V.I.u.	1994	INS
45	Inherited metabolic disorders of the transsulfuration pathway (1404882)	Haraguchi H.	1992	SOD1, CBS, XDH
46	The dibasic amino acid metabolic disorders (1404883)	Shimizu H.	1992	OTC
47	Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders. (1761630)	Jellum E.... Time E.	1991	GSS, ADSL
48	Pathophysiology and therapy of lipid metabolism disorders in kidney diseases (1921228)	Olbricht C.J.	1991	LPL
49	Use of xidifon for prevention and treatment of nephropathies with metabolic disorders in children (2349037)	Korovina N.A.... Dunaeva I.P.	1990	B2M
50	Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease (1979835)	Poliakov A.P.... Surguchev A.P.	1990	APOB

Genes related to metabolic disorders according to GeneCards:

(show top 50)    (show all 256)

id	Symbol	Description	Score	GeneCards Section Context
1	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Summaries, Publications
2	HGD	homogentisate 1,2-dioxygenase	11.0	Summaries
3	ACY1	aminoacylase 1	11.0	Summaries
4	GSTZ1	glutathione S-transferase zeta 1	11.0	Summaries
5	INS	insulin	11.0	Publications
6	APRT	adenine phosphoribosyltransferase	11.0	Publications
7	DPYD	dihydropyrimidine dehydrogenase	11.0	Publications
8	ADSL	adenylosuccinate lyase	11.0	Publications
9	ACAT1	acetyl-CoA acetyltransferase 1	11.0	Publications
10	OTC	ornithine carbamoyltransferase	11.0	Publications
11	APOA1	apolipoprotein A-I	11.0	Publications
12	LPL	lipoprotein lipase	11.0	Publications
13	ADA	adenosine deaminase	11.0	Publications
14	PPARA	peroxisome proliferator-activated receptor alpha	11.0	Publications
15	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
16	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
17	BCS1L	BCS1-like (S. cerevisiae)	11.0	Publications
18	SUOX	sulfite oxidase	11.0	Publications
19	GALK1	galactokinase 1	11.0	Publications
20	PPOX	protoporphyrinogen oxidase	11.0
21	PNPLA2	patatin-like phospholipase domain containing 2	11.0
22	LBX1	ladybird homeobox 1	11.0
23	SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	11.0
24	PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	11.0
25	IRS2	insulin receptor substrate 2	11.0	Publications
26	CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	11.0
27	ESRRA	estrogen-related receptor alpha	11.0	Publications
28	CTSA	cathepsin A	11.0
29	HEXA	hexosaminidase A (alpha polypeptide)	11.0
30	HMBS	hydroxymethylbilane synthase	11.0
31	HPD	4-hydroxyphenylpyruvate dioxygenase	11.0
32	IDUA	iduronidase, alpha-L-	11.0
33	PYGM	phosphorylase, glycogen, muscle	11.0
34	MVK	mevalonate kinase	11.0
35	RPIA	ribose 5-phosphate isomerase A	11.0
36	FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	11.0
37	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0	Publications
38	MUT	methylmalonyl CoA mutase	11.0
39	GALT	galactose-1-phosphate uridylyltransferase	11.0	Publications
40	GAA	glucosidase, alpha; acid	11.0	Publications
41	MSTN	myostatin	11.0
42	MMAB	methylmalonic aciduria (cobalamin deficiency) cblB type	11.0
43	FOXM1	forkhead box M1	11.0
44	GK	glycerol kinase	11.0
45	FMO3	flavin containing monooxygenase 3	11.0
46	OAT	ornithine aminotransferase	11.0
47	L2HGDH	L-2-hydroxyglutarate dehydrogenase	11.0
48	ETFDH	electron-transferring-flavoprotein dehydrogenase	11.0
49	ASS1	argininosuccinate synthase 1	11.0	Publications
50	CAPN10	calpain 10	11.0	Publications

Pathways related to metabolic disorders according to GeneDecks:

(show top 50)    (show all 62)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	INF	HLCS, GGT1, GAMT, GAA, GALT, GALNT3
2	PPAR signaling pathway20	11.5	ADIPOQ, PCK2, PCK1, LPL, SCD, CPT2
3	Lysosome20	11.4	SMPD1, ACP2, HEXA, CTSA, CTNS, GLA
4	Metabolism38	11.3	G6PD, RPIA, PPOX, PTS, GCH1, HMBS
5	Valine, leucine and isoleucine degradation20	11.2	HADHA, MUT, ACADS, HMGCL, ALDH9A1, HADH
6	Fatty acid metabolism20	11.2	ALDH2, ACADVL, HADHA, ALDH9A1, ACADM, HADH
7	Galactose metabolism20	11.2	GALK1, G6PC, GALT, AKR1B1, GLA, GCK
8	Metabolism of amino acids and derivatives38	11.1	GAMT, DBH, HGD, GATM, GPT, SUOX
9	Arginine and proline metabolism20	11.1	ALDH2, ACY1, OTC, ALDH9A1, CPS1, GATM
10	AMPK Enzyme Complex Pathway36	11.1	GYS2, INSR, GNB3, FASN, IRS2, IRS1
11	Adipocytokines & Insulin Signaling37	11.1	PRKAB1, GYS1, INS, INSR, PRKAA1, PRKAA2
12	Butanoate metabolism20	11.1	PDHA1, ALDH5A1, HADHA, ACAT1, ACADS, L2HGDH
13	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	11.0	ABCC8, GCK, IRS2, IRS1, INS, INSR
14	Type II diabetes mellitus20	11.0	ABCC8, SLC2A2, ADIPOQ, GCK, IRS2, IRS4
15	Development Leptin signaling via PI3K-dependent pathway10	11.0	PRKAB1, LEPR, GYS2, IRS1, IRS2, ABCC8
16	Fatty acid, triacylglycerol, and ketone body metabolism38	11.0	ACADS, MUT, PCCB, PCCA, HMGCL, ABCA1
17	Glycolysis and gluconeogenesis (short map)10	10.9	G6PC, GCK, PGAM2, PCK1, ENO3, ALDOA
18	Galactose metabolism41	10.9	GYS2, PYGL, PYGM, G6PC, PGM1, GALT
19	Development_Leptin signaling via PI3K-dependent pathway41	10.9	IRS1, PRKAA1, LEP, GYS2, LEPR, IRS2
20	Galactose metabolism10	10.9	GCK, GYS1, GLA, PYGL, PYGM, G6PC
21	Glycolysis and gluconeogenesis (short map)41	10.9	PGAM2, SLC37A4, G6PC, TPI1, ALDOA, ENO3
22	Glucose transport38	10.9	SLC2A2, GCK, G6PC, SLC2A1, SLC37A4
23	Alanine, aspartate and glutamate metabolism20	10.9	CPS1, AGXT, ADSL, GLUD1, ASS1, GPT
24	Metabolism of lipids and lipoproteins38	10.8	HSD11B1, GLA, AKR1B1, CYP7A1, CYP21A2, SREBF1
25	Purine metabolism38	10.8	AMPD3, APRT, ADSL, ADK, ADA, AMPD1
26	Selected targets of C/EBPbeta10	10.7	RETN, UCP3, VWF, SLC2A2, MBP, APOB
27	Aldosterone-regulated sodium reabsorption20	10.7	IRS4, HSD11B1, INS, IRS2
28	Statin Pathway, Pharmacodynamics34	10.7	LDLR, LCAT, APOB, APOA1, CYP7A1, LPL
29	ATP/ITP metabolism10	10.7	HPRT1, AMPD3, AMPD1, APRT, PNP, ACP2
30	Insulin signaling pathway20	10.7	PRKAB1, PRKAA2, PRKAA1, TSC1, G6PC, PHKG2
31	ATP/ITP metabolism41	10.7	ADK, ADSL, ACP2, PNP, HPRT1, AMPD3
32	Metformin Pathway, Pharmacodynamic34	10.6	SIRT1, SREBF1, PPARGC1A, NR1I2, NDUFS4, PRKAA1
33	Porphyrin and chlorophyll metabolism20	10.6	FECH, MMAB, UROS, UROD, HMBS, PPOX
34	Selected targets of C/EBPalpha10	10.6	RETN, APOB, ADIPOQ, CETP, FOXM1, ALB
35	Tryptophan metabolism20	10.5	GCDH, ALDH2, ALDH9A1, ACAT1, HADHA, HADH
36	Selected targets of HNF110	10.4	IAPP, SLC2A2, DPP4, ABCA1, IGFBP1, CRP
37	Starch and sucrose metabolism20	10.4	GCK, GYS1, GYS2, PYGL, PYGM, AGL
38	Glycogen metabolism10	10.4	GYS1, GYS2, PYGL, PYGM, AGL, GBE1
39	Glycogen metabolism41	10.3	GCK, GYS1, GYS2, PYGL, PYGM, AGL
40	Transcription Receptor-mediated HIF regulation10	10.2	IGF1, IGFBP3, INSR, INS, IRS4, IRS2
41	Adipocytokine signaling pathway20	10.1	IRS4, IRS2, IRS1, LEPR, LEP, PCK1
42	Selected targets of GCR-alpha10	10.0	GHSR, NR1I2, IGFBP1, INSR, NR1I3, GHR
43	Glucose metabolism38	10.0	GBE1, PGM1, SLC25A13, AGL, PHKG2, PHKB
44	Transcription_Receptor-mediated HIF regulation41	9.9	INSR, INS, IRS4, IRS2, IGF1, IRS1
45	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	BGLAP, IL6, APOE, CA2, TNF, NR3C1
46	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.0	NR3C1, TNF, CA2, IGF1, APOE, BGLAP
47	Propanoate metabolism20	INF	ALDH2, , PCCA, MUT, ACADM, PCCB
48	Glycolysis / Gluconeogenesis20	INF	PDHA1, PGAM2, G6PC, PCK1, GCK,
49	Pyruvate metabolism20	INF	PCK1, , ALDH2, ALDH9A1, AKR1B1, PCK2
50	Glucose / Energy Metabolism3	INF	G6PD, IRS2, IRS1, GYS1, , SCD

Compounds related to metabolic disorders according to GeneDecks:

(show top 50)    (show all 622)

id	Compound	Score	Top Affiliating Genes
1	atp32	INF	PC, PCCA, PCK2, GCK, LMNA, SCD
2	lactate32	INF	VWF, PC, PCK2, GCK, GCG, BTD
3	acyl-coa32	11.7	PC, PCK2, GCDH, BTD, LPL, SCD
4	acetyl-coa32 18	12.5	NCOA1, PC, PCK2, GCK, GCDH, NAGS
5	nadph32 18	12.4	PC, GCK, GCH1, UCP2, QDPR, FMO3
6	mannose 6-phosphate32 18	12.2	LRP1, GCK, ARSA, INSR, IGFBP1, IGF1
7	glycerol32 9 18 9	14.2	VWF, PC, PCK2, PCK1, GCK, GCG
8	phenylalanine32	11.1	GCH1, BTD, MVK, QDPR, INSR, FGF23
9	glycerol 3-phosphate32 18	12.0	PC, PCK2, PCK1, GCK, LPL, SCD
10	linoleic acid32 18	12.0	LPL, SCD, LDLR, UCP1, UCP2, LCAT
11	2-deoxyglucose32	10.8	GCK, IRS1, INS, INSR, IGF1, GHRL
12	pge232	10.8	LDLR, AQP2, APOA1, CASR, CA2, HP
13	phosphatidylcholine32	10.7	CNR1, LPL, SCD, LDLR, LCAT, LBP
14	forskolin32 42 9 9	13.7	RETN, GCK, GCG, UCP1, GYS1, AQP2
15	histidine32	10.7	MVK, MUT, AMPD3, CBS, CA2, GIP
16	palmitate32	10.7	PC, GCG, SCD, LDLR, UCP1, UCP2
17	guanine32 9 18 9	13.6	CNR1, VWF, GCG, GCH1, LPL, VDR
18	glycogen32 18	11.5	LRP1, RETN, PC, PCK2, PCK1, GCK
19	phenobarbital32 9 9	12.4	LPL, UROD, FOXM1, APOA1, GPT, ALDH9A1
20	glibenclamide32 34	11.3	CNR1, GCG, LEP, INS, INSR, APOA1
21	ibmx32	10.1	PCK2, GCG, LPL, SCD, MMP2, IRS1
22	fluvastatin32 34 9 9	13.1	VWF, SELP, SERPINE1, LPL, CHKB, LDLR
23	cysteine32	10.0	LRP1, PCK2, GCK, GCG, BTD, SELP
24	triiodothyronine32	10.0	NCOA1, PCK2, LEP, LEPR, CHKB, UCP1
25	adenylate32	9.7	CNR1, VWF, GCK, GCG, SELP, SERPINE1
26	p00332	9.7	RETN, SERPINE1, SCD, LEP, UCP1, UCP2
27	superoxide32 18	10.6	PC, GCH1, LEPR, CHKB, UCP1, UCP2
28	dehydroepiandrosterone sulfate32	9.5	LEP, INS, IGFBP1, IGFBP3, IGF1, GH1
29	vitamin-e32	9.4	SCD, UCP2, B2M, GSS, GPT, F7
30	uric acid32 18	10.3	RETN, SERPINE1, LEP, CHKB, XDH, B2M
31	rosiglitazone32 9 18 9	12.1	LRP1, NCOA1, RETN, PCK2, PCK1, SERPINE1
32	alpha lipoic acid32	9.0	PC, BTD, INS, INSR, GSS, CAT
33	methotrexate32 34 42 9 9	12.5	SERPINE1, LEP, CHKB, QDPR, MMP2, IL6
34	homocysteine32 18	9.5	RETN, VWF, SELP, SERPINE1, LBP, CETP
35	actinomycin d32	8.5	RETN, SERPINE1, VDR, LDLR, LBP, IRS1
36	atorvastatin32 34 9 18 9	12.3	RETN, VWF, SELP, SERPINE1, LPL, CHKB
37	thyroxine32 18	9.0	RETN, VWF, LPL, VDR, BGLAP, LEP
38	fibrinogen32	8.0	RETN, VWF, SELP, SERPINE1, NAMPT, LEP
39	pyruvate32	INF	PC, PCK2, GCK, USF1, CHKB, UCP1
40	leucine32	INF	LRP1, NCOA1, PCK2, GCK, LMNA, USF1
41	glutamate32	INF	NCOA1, CNR1, PC, PCK2, GCK, GCG
42	glucose32	INF	PC, GCG, GCH1, BTD, , MSTN
43	cocaine32 9 9	INF	CNR1, GCG, SELP, , LEP, LEPR
44	lovastatin32 42 9 9	INF	LRP1, LPL, LMNA, , CHKB, MVK
45	calcium32 9 18 9	INF	LRP1, SH2D4B, KL, RETN, CNR1, VWF
46	lead32	INF	, CHKB, B2M, QDPR, ARSA, FECH
47	acetylcholine32 9 18 9	INF	CNR1, VWF, GCG, LPL, , LEP
48	simvastatin32 34 42 9 18 9	INF	VWF, SELP, SERPINE1, LPL, BGLAP,
49	nadh32 9 18 9	INF	PC, GCK, NAMPT, , XDH, QDPR
50	pravastatin32 34 9 18 9	INF	SELP, SERPINE1, , CHKB, LDLR, LCAT

Cellular components related to metabolic disorders according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	ENO3, HMBS, TPI1, , PYGL, PYGM
2	mitochondrial inner membrane	GO:005743	11.2	IMMT, L2HGDH, UCP3, UCP2, SLC25A13, FECH
3	lysosomal lumen	GO:043202	11.1	GBA, ARSA, IDUA, GLA, CTSA, SMPD1
4	mitochondrial matrix	GO:005759	11.0	PC, SUOX, OTC, OAT, NR3C1, PDHA1
5	lysosome	GO:005764	10.8	CTSA, CTNS, ACP2, CHIT1, LDLR, ASS1
6	integral to mitochondrial inner membrane	GO:031305	10.6	PPOX, ETFDH, IMMT, L2HGDH
7	endoplasmic reticulum lumen	GO:005788	10.5	ARSA, STS, GCG, B2M, INS, APOA1
8	secretory granule	GO:030141	10.4	GCK, GCG, GAL, POMC, INS, DBH
9	phosphorylase kinase complex	GO:005964	10.3	PHKA2, PHKG2, PHKA1, PHKB
10	peroxisome	GO:005777	10.0	XDH, CAT, HMGCL, ABCD1, AGXT, SOD1
11	endoplasmic reticulum	GO:005783	9.8	ASS1, CD320, ATP8B1, CIDEC, SCD, DHCR24
12	plasma membrane	GO:005886	7.6	MBP, FABP2, KL, FASN, APOE, APOB
13	extracellular space	GO:005615	5.6	PLAT, CRP, SMPD1, PTHLH, TNF, GHRL
14	extracellular region	GO:005576	INF	CP, COL20A1, PLAT, CRP, PTHLH, TNFRSF1B
15	mitochondrion	GO:005739	INF	MMAB, MUT, ALDH5A1, ALDH9A1, GLUD1, GHR
16	cytoplasm	GO:005737	INF	HFE, AGL, AHCY, TTF2, TTR, G6PD

Biological processes related to metabolic disorders according to GeneDecks:

(show top 50)    (show all 104)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	INF	PAH, GYS2, ARSA, INS, GSS, GSTZ1
2	cellular lipid metabolic process	GO:044255	11.8	SLC27A1, CPT1A, CPT2, HADH, HADHA, PRKAA2
3	cellular nitrogen compound metabolic process	GO:034641	11.4	GCDH, POMC, CPS1, HGD, GATM, GAMT
4	fatty acid beta-oxidation	GO:006635	11.4	ADIPOQ, HADH, HADHA, ACADS, ABCD1, PPARD
5	response to insulin stimulus	GO:032868	11.3	HADH, GAL, SIRT1, TSC1, UCP3, NR3C1
6	L-phenylalanine catabolic process	GO:006559	11.2	TAT, GSTZ1, HPD, FAH, QDPR, PAH
7	energy reserve metabolic process	GO:006112	11.2	GNB3, GIP, ABCC8, TALDO1, PRKAA2, GLP1R
8	tyrosine catabolic process	GO:006572	11.2	GSTZ1, HPD, TAT, HGD, FAH
9	phospholipid metabolic process	GO:006644	11.2	PNPLA2, ACHE, TAZ, HEXA, SMPD1, STS
10	glucose homeostasis	GO:042593	11.1	PCK1, GCK, SERPINE1, USF1, IRS1, INS
11	cholesterol transport	GO:030301	11.0	LCAT, LDLR, APOA1, APOB, NPC1, CETP
12	insulin receptor signaling pathway	GO:008286	11.0	INSR, PTPN1, IGFBP1, INS, IRS2, IRS1
13	cholesterol homeostasis	GO:042632	11.0	LCAT, CETP, SIRT1, NPC1, G6PC, ABCA1
14	response to nutrient	GO:007584	11.0	GATM, ADIPOQ, ADSL, HMGCL, CNR1, UCP3
15	response to estrogen stimulus	GO:043627	10.9	BGLAP, CA2, F7, MSTN, SERPINE1, GAL
16	purine-containing compound salvage	GO:043101	10.9	PNP, ADK, ADA, HPRT1, AMPD3, AMPD1
17	transcription initiation from RNA polymerase II promoter	GO:006367	10.8	PPARA, VDR, NR1I3, NR1I2, NR1H4, NR1H2
18	response to starvation	GO:042594	10.8	CPS1, ACAT1, PPARGC1A, HMGCL, GIP, ACADS
19	glycosphingolipid metabolic process	GO:006687	10.8	STS, SMPD1, CTSA, GBA, HEXA, NEU1
20	positive regulation of glucose import	GO:046326	10.8	ADIPOQ, INSR, IRS1, IRS2, INS, CAPN10
21	glucose transport	GO:015758	10.8	GCK, GH1, PPARD, SLC37A4, INS, G6PC
22	nucleobase-containing small molecule metabolic process	GO:055086	10.8	ADA, AMPD1, CAT, AMPD3, APRT, XDH
23	purine nucleobase metabolic process	GO:006144	10.7	XDH, APRT, ADK, AMPD1, AMPD3, CAT
24	gluconeogenesis	GO:006094	10.7	ENO3, GPT, ALDOA, PCK1, TPI1, PPARGC1A
25	positive regulation of glycogen biosynthetic process	GO:045725	10.7	INSR, IGF1, IRS2, IRS1, GCK, INS
26	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.7	ABCA1, ADIPOQ, CRP, NR1H2, CETP, PPARG
27	lipid metabolic process	GO:006629	10.7	LCAT, CETP, HNF4A, UCP3, APOE, LDLR
28	cholesterol metabolic process	GO:008203	10.7	CAT, LEP, LEPR, LDLR, LCAT, CETP
29	aging	GO:007568	10.6	AQP2, ADRB3, ADA, NR3C1, ENO3, ASS1
30	positive regulation of insulin secretion	GO:032024	10.6	GIP, GHRL, GLP1R, CAPN10, IRS2, GCK
31	cellular response to insulin stimulus	GO:032869	10.6	INSR, IRS1, CAPN10, IRS2, GCK, ADIPOQ
32	negative regulation of inflammatory response	GO:050728	10.5	APOA1, GBA, ADA, ADRB2, TNFRSF1B, GHSR
33	positive regulation of glycolysis	GO:045821	10.5	GCK, INS, INSR, IGF1, PRKAA1, PRKAA2
34	carbohydrate metabolic process	GO:005975	10.5	AGL, GBE1, GALK1, GALNT3, GALT, GBA
35	intracellular receptor mediated signaling pathway	GO:030522	10.5	ESRRA, NR1I3, NR1H4, PPARD, ESRRB, NR1I2
36	glycogen catabolic process	GO:005980	10.5	PYGM, PHKA1, PHKA2, PHKB, PHKG2, G6PC
37	lipoprotein metabolic process	GO:042157	10.4	CETP, LPL, APOA1, LDLR, ALB, PPARA
38	generation of precursor metabolites and energy	GO:006091	10.4	PHKB, ADIPOQ, ADRB3, PHKG2, PHKA2, PHKA1
39	glycogen metabolic process	GO:005977	10.4	G6PC, PHKG2, PHKB, PHKA1, PYGM, PYGL
40	positive regulation of cholesterol efflux	GO:010875	10.4	ADIPOQ, LRP1, APOE, NR1H2, ABCA1, SIRT1
41	response to glucose stimulus	GO:009749	10.3	NR1H4, ADIPOQ, GYS2, IRS2, INSR, GLP1R
42	glycogen biosynthetic process	GO:005978	10.3	GYS1, GBE1, PGM1, GCK, AGL, PHKG2
43	regulation of insulin secretion	GO:050796	10.3	TNF, SLC2A2, SLC2A1, CNR1, GCK, GCG
44	triglyceride metabolic process	GO:006641	10.3	APOE, CPT1A, G6PC, CAT, LPL, CETP
45	positive regulation of cell proliferation	GO:008284	9.9	GLP1R, IGF1, IL6, INSR, PTHLH, PPARD
46	response to activity	GO:014823	9.9	HADH, PRKAA1, NR3C1, PCK1, BGLAP, UCP3
47	glucose metabolic process	GO:006006	9.4	IRS2, PGM1, ADIPOQ, GBE1, GAA, PC
48	response to hypoxia	GO:001666	9.2	HMBS, TNF, PYGM, USF1, PPARA, CRP
49	response to glucocorticoid stimulus	GO:051384	INF	SERPINE1, PCK2, LCAT, UCP3, , BGLAP
50	response to drug	GO:042493	INF	OTC, PPOX, PPARG, ENO3, PNP, BGLAP

Molecular functions related to metabolic disorders according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	flavin adenine dinucleotide binding	GO:050660	11.0	PPOX, ACADS, ACADM, ACADVL, DPYD, ETFDH
2	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.9	PPARA, ESRRB, NR1H2, NR1H4, PPARD, NR1I2
3	steroid hormone receptor activity	GO:003707	10.8	VDR, HNF4A, ESRRA, ESRRB, PPARG, PPARA
4	receptor binding	GO:005102	10.8	CAT, GBA, ADIPOQ, NPY, POMC, F7
5	amino acid binding	GO:016597	10.8	TAT, AGXT, PAH, FMO3, OTC
6	insulin receptor binding	GO:005158	10.6	SLC2A2, IRS2, IGF1, INS, IRS4, IRS1
7	cation binding	GO:043169	10.6	GBA, GBE1, AGL, HEXA, GLA, IDUA
8	glucose binding	GO:005536	10.5	GYS1, PYGL, G6PD, GYG1, GCK
9	phosphorylase kinase activity	GO:004689	10.2	PHKA1, PHKG2, PHKB, PHKA2
10	pyridoxal phosphate binding	GO:030170	10.2	CBS, OAT, TAT, GPT, AGXT, ALB
11	cholesterol binding	GO:015485	10.2	CETP, ABCA1, NPC1, APOA1, CRP
12	drug binding	GO:008144	10.1	CNR1, PNP, PPARD, ACE, ADRB2, ALB
13	hormone activity	GO:005179	10.1	IAPP, IGF1, INS, LEP, KL, RETN
14	hydrolase activity, hydrolyzing O-glycosyl compounds	GO:004553	9.7	PHKA1, GBE1, PHKB, PHKA2
15	identical protein binding	GO:042802	9.6	APOA1, ALDOA, SLC2A1, SIRT1, CPT1A, ACADM
16	protein homodimerization activity	GO:042803	9.4	ENO3, G6PD, AGXT, DPP4, DPYD, SOD1
17	protein binding	GO:005515	6.2	PRKAA1, TF, DPP4, TSC1, TTR, TTF2
18	enzyme binding	GO:019899	INF	APOB, HLCS, SLPI, DHCR24, ABCD1, PHKG2