AOMS1
MCID: MTB001
MIFTS: 56

Metabolic Syndrome X (AOMS1) malady

Rare diseases category

Summaries for Metabolic Syndrome X

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35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Metabolic Syndrome X, also known as abdominal obesity-metabolic syndrome, is related to coronary artery disease and polycystic ovary syndrome. An important gene associated with Metabolic Syndrome X is AOMS1 (Abdominal obesity-metabolic syndrome QTL1), and among its related pathways are FoxO signaling pathway and Arf6 trafficking events. The drugs magnesium hydroxide and milk of magnesia and the compounds ribonucleic acid and cortisone have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are cardiovascular system and adipose tissue.

Wikipedia:66 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of... more...

Description from OMIM:48 605552

Aliases & Classifications for Metabolic Syndrome X

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Sources:
9Disease Ontology, 66Wikipedia, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 36MeSH, 41NCIt, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

metabolic syndrome x 9 44 23 11 46 63
abdominal obesity-metabolic syndrome 9 48
abdominal obesity metabolic syndrome 44 63
metabolic disorders 66 35
metabolic syndrome 9 35
dysmetabolic syndrome x 9
metabolic diseases 63
metabolic disorder 46
aoms1 44


External Ids:

Disease Ontology9 DOID:14221
ICD9CM28 277.7
MeSH36 D024821
NCIt41 C84442
OMIM48 605552

Related Diseases for Metabolic Syndrome X

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Metabolic Syndrome X family:

Acquired Metabolic Disease

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 978)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease30.8IGFBP1, INS, SERPINE1
2polycystic ovary syndrome30.8INS, IGFBP1
3fatty liver disease30.8INS, SERPINE1
4lipodystrophy30.7HSD11B1, INS
5hypertriglyceridemia30.5SLC2A4, SERPINE1, INS
6hypertension30.5SERPINE1, HSD11B1, INS
7glucose intolerance30.5SLC2A4, SERPINE1, INS, IGFBP1
8obesity30.5IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
9insulin resistance30.5IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
10gestational diabetes30.5SLC2A4, INS, IGFBP1
11essential hypertension30.4SERPINE1, INS
12hypercholesterolemia30.3SERPINE1, INS
13hyperandrogenism30.2IGFBP1, INS
14atherosclerosis30.2INS, HSD11B1, SERPINE1
15growth hormone deficiency30.1INS, IGFBP1
16diabetes mellitus30.1IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
17breast cancer30.1SLC2A4, SERPINE1, INS, IGFBP1
18cushing's syndrome30.1HSD11B1, IGFBP1
19acute myocardial infarction30.0IGFBP1, SERPINE1
20diabetic nephropathy29.9SERPINE1, INS
21hyperglycemia29.9IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
22type 2 diabetes mellitus29.9IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
23acromegaly29.7IGFBP1, INS, HSD11B1
24familial hyperlipidemia29.7SERPINE1, HSD11B1, INS
25adenoma29.7IGFBP1, INS, HSD11B1
26hyperinsulinism29.6IGFBP1, INS, SERPINE1
27endotheliitis10.6
28artery disease10.6
29liver disease10.6
30hyperuricemia10.5
31lipid metabolism disorder10.5
32hepatitis10.5
33kidney disease10.5
34hypogonadism10.4
35psoriasis10.4
36schizophrenia10.4
37nephrolithiasis10.3
38sleep apnea10.3
39carbohydrate metabolic disorder10.3
40obstructive sleep apnea10.3
41cerebritis10.3
42arthritis10.3
43glycogen storage disease iv10.3
44periodontitis10.3
45galactosemia10.3
46morbid obesity10.3
47prostatitis10.3
48nonalcoholic steatohepatitis10.3
49familial combined hyperlipidemia10.2
50cystinuria10.2

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Symptoms for Metabolic Syndrome X

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Sources:
48OMIM
See all sources


Clinical features from OMIM:

605552

Drugs & Therapeutics for Metabolic Syndrome X

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Metabolic Syndrome X

Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Search CenterWatch for Metabolic Syndrome X

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Metabolic Syndrome X

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Sources:
23GTR
See all sources

Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X23

Anatomical Context for Metabolic Syndrome X

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34MalaCards
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MalaCards organs/tissues related to Metabolic Syndrome X:

34
Heart, Kidney, Brain, Liver, Pituitary

Animal Models for Metabolic Syndrome X or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Metabolic Syndrome X:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4SLC2A4, SERPINE1, HSD11B1, INS
2MP:00053758.3INS, HSD11B1, SERPINE1, SLC2A4
3MP:00053707.5SLC2A4, SERPINE1, HSD11B1, INS, IGFBP1
4MP:00053877.2IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4

Publications for Metabolic Syndrome X

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Sources:
53PubMed
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Articles related to Metabolic Syndrome X:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. (23923606)
2013
2
Anaesthetic considerations in metabolic syndrome X. (20532086)
2010
3
Central retinal artery occlusion in a patient with metabolic syndrome x. (22737328)
2010
4
Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. (19374165)
2009
5
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
6
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? (17475465)
2007
7
Cardiac syndrome X versus metabolic syndrome X. (17010457)
2007
8
Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. (16999025)
2006
9
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X. (16416266)
2006
10
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. (15734832)
2005
11
Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)
2005
12
HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure. (15470277)
2004
13
Metabolic syndrome X: an inflammatory condition? (14972097)
2004
14
Low-flow vascular remodeling in the metabolic syndrome X. (14644764)
2004
15
Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)
2003
16
Metabolic syndrome X is common in Indians: but, why and how? (14719590)
2003
17
The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)
2003
18
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. (12756274)
2003
19
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. (12697574)
2003
20
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. (15028595)
2003
21
Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. (12781862)
2003
22
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)
2003
23
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)
2003
24
Metabolic syndrome X--high risk factor for acute myocardial infarction and its complications. (12137304)
2002
25
Molecular mechanism of vascular disease in metabolic syndrome X. (11872360)
2002
26
The metabolic syndrome X and peripheral cortisol synthesis. (12397528)
2002
27
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. (12512799)
2002
28
Metabolic syndrome X is common in South Asians, but why and how? (12297221)
2002
29
Obesity, metabolic syndrome X, and inflammation. (11985951)
2002
30
Is metabolic syndrome X an inflammatory condition? (12486208)
2002
31
Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. (11958275)
2001
32
Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. (15573024)
2001
33
Steroid metabolism in metabolic syndrome X. (11469814)
2001
34
Metabolic syndrome X and fibrinolytic disturbances. (10870268)
2000
35
Metabolic syndrome X: a review. (10863169)
2000
36
Insulin resistance: the metabolic syndrome X (10713753)
2000
37
Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine. (11057441)
2000
38
The metabolic syndrome X. (10842649)
1999
39
Hypothalamic origin of the metabolic syndrome X. (10842670)
1999
40
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
41
Liver pathology and the metabolic syndrome X in severe obesity. (10323371)
1999
42
Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. (10189006)
1999
43
Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)
1998
44
Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)
1998
45
Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)
1998
46
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)
1997
47
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)
1996
48
Clinical manifestations of the insulin resistance syndrome. The hormonal-metabolic syndrome X, the 5H syndrome and their etiopathogenesis]. (7725646)
1995
49
Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete. (1644073)
1992
50
Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. (1509712)
1992

Variations for Metabolic Syndrome X

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Expression for genes affiliated with Metabolic Syndrome X

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Metabolic Syndrome X

Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 13EMD Millipore, 61Thomson Reuters, 56Reactome
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Pathways related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.3SLC2A4, INS
29.3SLC2A4, INS
3
Show member pathways
9.3INS, SLC2A4
49.3SLC2A4, INS
59.3SERPINE1, INS
69.3SERPINE1, INS
7
Show member pathways
thioredoxin pathway39
9.3INS, SERPINE1
89.1SERPINE1, IGFBP1
99.0INS, IGFBP1
109.0INS, IGFBP1
119.0INS, IGFBP1
128.8SLC2A4, SERPINE1, INS
13
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.8INS, SERPINE1, SLC2A4

Compounds for genes affiliated with Metabolic Syndrome X

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1ribonucleic acid469.8SLC2A4, HSD11B1
2cortisone46 2510.7INS, HSD11B1
3repaglinide52 46 1211.7INS, SERPINE1
4ramipril46 1210.7INS, SERPINE1
5gliclazide46 52 1211.7SLC2A4, INS
6cyproteroneacetate469.6INS, SERPINE1
7ciglitazone46 3010.6SERPINE1, SLC2A4
8gemfibrozil30 46 1211.6SERPINE1, INS
911beta-hydroxysteroid469.5SLC2A4, HSD11B1
108-isoprostane469.4SERPINE1, INS
11fructosamine46 2510.4IGFBP1, INS
12beta-hydroxybutyrate469.4IGFBP1, INS
13clomiphene citrate469.4INS, IGFBP1
14bezafibrate46 30 1211.3INS, SERPINE1
15glimepiride46 52 1211.3SLC2A4, INS, SERPINE1
16sulfonylurea469.3SERPINE1, SLC2A4, INS
17thiazolidinedione469.2SERPINE1, INS, SLC2A4
18aicar46 25 1211.2SLC2A4, INS
19troglitazone46 30 62 1212.2INS, SLC2A4, SERPINE1
20phosphoenolpyruvate46 1210.1IGFBP1, HSD11B1, SLC2A4
21ly294002469.0INS, SLC2A4, SERPINE1
22dhea469.0IGFBP1, INS, HSD11B1
23androstenedione46 2510.0INS, IGFBP1, HSD11B1
24hydrocortisone46 3 62 1212.0IGFBP1, INS, HSD11B1
25acth468.9HSD11B1, INS, IGFBP1
26chloramphenicol46 3 52 1211.9SERPINE1, IGFBP1, SLC2A4
272-deoxyglucose46 129.9IGFBP1, SLC2A4, INS
28c-peptide468.9INS, SERPINE1, IGFBP1
29gnrh468.9IGFBP1, SERPINE1, INS
30fibrinogen468.8SERPINE1, INS, IGFBP1
31norepinephrine46 25 1210.8INS, SLC2A4, IGFBP1
32actinomycin d468.8SLC2A4, SERPINE1, IGFBP1
33rapamycin468.8INS, SLC2A4, IGFBP1
34estradiol46 25 1210.7SERPINE1, HSD11B1, IGFBP1
35progesterone46 30 62 25 1212.5IGFBP1, HSD11B1, SERPINE1, SLC2A4
36glycerol46 25 1210.5SLC2A4, INS, HSD11B1, IGFBP1
37glycogen46 259.5HSD11B1, SLC2A4, INS, IGFBP1
38fatty acid468.5IGFBP1, INS, SLC2A4, HSD11B1
39metformin46 52 1210.4IGFBP1, SLC2A4, INS, SERPINE1
40cholesterol46 30 25 1211.4SERPINE1, INS, IGFBP1, HSD11B1
41alanine468.4SLC2A4, HSD11B1, IGFBP1, INS
42creatinine468.4SLC2A4, SERPINE1, INS, IGFBP1
43forskolin46 52 1210.4SLC2A4, IGFBP1, HSD11B1
44estrogen468.3IGFBP1, HSD11B1, SERPINE1, INS
45pioglitazone30 46 52 1211.0IGFBP1, HSD11B1, SLC2A4, SERPINE1, INS
46rosiglitazone30 46 52 25 1212.0HSD11B1, SERPINE1, IGFBP1, SLC2A4, INS
47testosterone46 62 25 1211.0SLC2A4, SERPINE1, HSD11B1, INS, IGFBP1
48dexamethasone46 52 30 1211.0HSD11B1, SLC2A4, INS, SERPINE1, IGFBP1
49glucose468.0INS, IGFBP1, SLC2A4, SERPINE1, HSD11B1
50lipid467.9HSD11B1, SERPINE1, INS, SLC2A4, IGFBP1

GO Terms for genes affiliated with Metabolic Syndrome X

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17Gene Ontology
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Biological processes related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:0425939.3SLC2A4, INS
2glucose transportGO:0157589.2SLC2A4, INS
3positive regulation of cell growthGO:0303078.7INS, IGFBP1

Molecular functions related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3SERPINE1, INS

Products for genes affiliated with Metabolic Syndrome X

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Metabolic Syndrome X

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet