AOMS1
MCID: MTB001
MIFTS: 69

Metabolic Syndrome X (AOMS1) malady

Rare diseases, Metabolic diseases categories

Summaries for Metabolic Syndrome X

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MedlinePlus:33 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Metabolic Syndrome X, also known as metabolic disorders, is related to morbid obesity and fatty liver disease. An important gene associated with Metabolic Syndrome X is AOMS2 (abdominal obesity-metabolic syndrome QTL2), and among its related pathways are HIF-1-alpha transcription factor network and Insulin-mediated glucose transport. The drugs magnesium hydroxide and milk of magnesia and the compounds glimepiride and glycerol 3-phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are tumorigenesis and reproductive system.

Wikipedia:64 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of... more...

Description from OMIM:46 605552

Aliases & Classifications for Metabolic Syndrome X

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Metabolic Syndrome X, Aliases & Descriptions:

Name: Metabolic Syndrome X 9 42 23 11 44 61
Metabolic Disorders 64 33 61
Abdominal Obesity-Metabolic Syndrome 9 46
Abdominal Obesity Metabolic Syndrome 42 61
Dysmetabolic Syndrome X 9 61
 
Metabolic Syndrome 9 33
Aoms1 42 61
Metabolic Disorder 44
Metabolic Diseases 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


External Ids:

Disease Ontology9 DOID:14221
ICD9CM28 277.7
NCIt39 C84442
MeSH34 D024821
OMIM46 605552

Related Diseases for Metabolic Syndrome X

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Diseases in the Metabolic Syndrome X family:

Acquired Metabolic Disease

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1032)
idRelated DiseaseScoreTop Affiliating Genes
1morbid obesity31.1LEP, INS
2fatty liver disease31.1CRP, LEP, INS, PPARG
3hypogonadism31.0ADIPOQ, LEPQTL1, LEP, INS
4obstructive sleep apnea31.0ADIPOQ, LEPQTL1, LEP
5polycystic ovary syndrome31.0SRD5A1, LEP, INSR, INS, IGFBP1
6schizophrenia30.8NR3C1, INSR, INS
7familial combined hyperlipidemia30.7LPL, ADIPOQ, LEPQTL1, INS
8eating disorder30.7LEP, INS
9acquired generalized lipodystrophy30.7ADIPOQ, LEP
10arteriosclerosis30.7LPL, ADIPOQ, SERPINE1, PPARG
11peripheral vascular disease30.6ALB, SERPINE1
12type 2 diabetes mellitus30.6SLC2A4, INSR
13acanthosis nigricans30.6ADIPOQ, LEP, INSR, INS
14cushing's syndrome30.5NR3C1, HSD11B1, INS
15hyperinsulinemic hypoglycemia30.5INS
16hyperhomocysteinemia30.4CRP, ALB, SERPINE1
17familial hyperlipidemia30.4LPL, INS
18lipodystrophy30.4LPL, ADIPOQ, HSD11B1, LEPQTL1, LEP, INSR
19gestational diabetes30.4SLC2A4, ADIPOQ, LEPQTL1, LEP, INSR, INS
20hypothyroidism30.4LEPQTL1, LEP, INS
21aortic aneurysm30.3CRP
22growth hormone deficiency30.3ADIPOQ, LEPQTL1, LEP, INS, IGFBP1
23prader-willi syndrome30.3ADIPOQ, LEPQTL1, LEP, INS
24familial hypertriglyceridemia30.3LPL, SERPINE1
25acute myocardial infarction30.3CRP, SERPINE1, IGFBP1
26infertility30.3LEPQTL1, LEP, INS, IGFBP1
27ovarian disease30.3INSR, IGFBP1
28diabetic ketoacidosis30.3LEPQTL1, INS
29cerebrovascular disease30.3CRP, LPL, SERPINE1, LEPQTL1, IGFBP1
30hepatitis c30.2ADIPOQ, TNF, LEPQTL1
31vascular disease30.2IL6, TNF
32hypercholesterolemia30.2CRP, LPL, ADIPOQ, SERPINE1, INSR, INS
33hypertriglyceridemia30.1SLC2A4, LPL, ADIPOQ, SERPINE1, LEPQTL1, LEP
34periodontal disease30.1CRP, IL6, TNF
35anorexia nervosa30.1ADIPOQ, LEPQTL1, LEP, IGFBP1
36myocardial infarction30.0CRP, ADIPOQ, SERPINE1, LEPQTL1, IGFBP1
37congenital adrenal hyperplasia30.0NR3C1, SRD5A1, LEPQTL1
38congenital generalized lipodystrophy type 229.9ADIPOQ, LEPQTL1, LEP, INSR, INS, PPARG
39diabetic nephropathy29.9ALB, ADIPOQ, SERPINE1, INS, PPARG
40adenoma29.9SRD5A1, HSD11B1, INSR, INS, IGFBP1, PPARG
41type 1 diabetes mellitus29.9ALB, LEPQTL1, LEP, INSR, INS, IGFBP1
42osteoporosis29.9NR3C1, IL6, HSD11B1, LEPQTL1, LEP
43tangier disease29.9LPL, PPARG
44essential hypertension29.9NR3C1, ALB, LPL, ADIPOQ, SERPINE1, LEP
45acromegaly29.9ADIPOQ, HSD11B1, LEPQTL1, LEP, INS, IGFBP1
46liver cirrhosis29.8SLC2A4, ALB, ADIPOQ, LEPQTL1, INSR
47protein-energy malnutrition29.8ALB, LEPQTL1, LEP, IGFBP1
48pancreatitis29.8CRP, ALB, IL6, LPL, INS
49nephrotic syndrome29.8NR3C1, ALB, LPL
50chronic obstructive pulmonary disease29.8CRP, IL6

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Symptoms for Metabolic Syndrome X

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Clinical features from OMIM:

605552

Drugs & Therapeutics for Metabolic Syndrome X

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Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Metabolic Syndrome X

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Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X23

Anatomical Context for Metabolic Syndrome X

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MalaCards organs/tissues related to Metabolic Syndrome X:

32
Heart, Kidney, Brain, Liver, Pituitary

Animal Models for Metabolic Syndrome X or affiliated genes

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MGI Mouse Phenotypes related to Metabolic Syndrome X:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1PPARG, LEP, TNF, SERPINE1, ADIPOQ, IL6
2MP:00053898.0INS, INSR, LEP, TNF, SRD5A1, NR3C1
3MP:00053678.0PPARG, INS, INSR, LEP, SERPINE1, ADIPOQ
4MP:00053908.0PPARG, INS, LEP, TNF, ADIPOQ, IL6
5MP:00053887.9INSR, LEP, TNF, HSD11B1, SERPINE1, ADIPOQ
6MP:00036317.7PPARG, INS, INSR, LEP, TNF, HSD11B1
7MP:00107717.7PPARG, INS, LEP, TNF, SERPINE1, ADIPOQ
8MP:00053867.5LEP, INSR, INS, PPARG, TNF, HSD11B1
9MP:00053817.4INS, INSR, LEP, TNF, FADS1, IL6
10MP:00053757.1PPARG, SLC2A4, NR3C1, PLIN1, IL6, LPL
11MP:00053977.0PPARG, INS, INSR, LEP, TNF, HSD11B1
12MP:00053787.0PPARG, INS, INSR, LEP, TNF, HSD11B1
13MP:00053856.9TNF, LEP, INSR, INS, PPARG, HSD11B1
14MP:00053796.9PPARG, INS, INSR, LEP, TNF, HSD11B1
15MP:00053696.8TNF, LEP, INSR, INS, PPARG, HSD11B1
16MP:00053846.7LEP, INSR, INS, IGFBP1, PPARG, TNF
17MP:00053706.4PPARG, IGFBP1, SLC2A4, NR3C1, ALB, PLIN1
18MP:00053876.3TNF, LEP, INSR, INS, IGFBP1, PPARG
19MP:00107686.3TNF, LEP, INSR, INS, PPARG, SERPINE1
20MP:00053765.6SERPINE1, HSD11B1, TNF, LEP, INSR, INS

Publications for Metabolic Syndrome X

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Articles related to Metabolic Syndrome X:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. (23923606)
2013
2
Anaesthetic considerations in metabolic syndrome X. (20532086)
2010
3
Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. (19374165)
2009
4
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
5
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? (17475465)
2007
6
Cardiac syndrome X versus metabolic syndrome X. (17010457)
2007
7
Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. (16999025)
2006
8
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X. (16416266)
2006
9
Aberrant expression of perilipins and 11-beta-HSD-1 as molecular signatures of metabolic syndrome X in south east Asians. (16941796)
2006
10
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. (15734832)
2005
11
Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)
2005
12
HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure. (15470277)
2004
13
Metabolic syndrome X: an inflammatory condition? (14972097)
2004
14
Low-flow vascular remodeling in the metabolic syndrome X. (14644764)
2004
15
Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)
2003
16
Metabolic syndrome X is common in Indians: but, why and how? (14719590)
2003
17
The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)
2003
18
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. (12756274)
2003
19
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. (12697574)
2003
20
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. (15028595)
2003
21
Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. (12781862)
2003
22
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)
2003
23
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)
2003
24
Metabolic syndrome X--high risk factor for acute myocardial infarction and its complications. (12137304)
2002
25
Molecular mechanism of vascular disease in metabolic syndrome X. (11872360)
2002
26
The metabolic syndrome X and peripheral cortisol synthesis. (12397528)
2002
27
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. (12512799)
2002
28
Metabolic syndrome X is common in South Asians, but why and how? (12297221)
2002
29
Obesity, metabolic syndrome X, and inflammation. (11985951)
2002
30
Is metabolic syndrome X an inflammatory condition? (12486208)
2002
31
Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. (11958275)
2001
32
Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. (15573024)
2001
33
Steroid metabolism in metabolic syndrome X. (11469814)
2001
34
Metabolic syndrome X and fibrinolytic disturbances. (10870268)
2000
35
Metabolic syndrome X: a review. (10863169)
2000
36
Insulin resistance: the metabolic syndrome X (10713753)
2000
37
Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine. (11057441)
2000
38
The metabolic syndrome X. (10842649)
1999
39
Hypothalamic origin of the metabolic syndrome X. (10842670)
1999
40
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
41
Liver pathology and the metabolic syndrome X in severe obesity. (10323371)
1999
42
Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. (10189006)
1999
43
Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)
1998
44
Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)
1998
45
Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)
1998
46
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)
1997
47
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)
1996
48
Clinical manifestations of the insulin resistance syndrome. The hormonal-metabolic syndrome X, the 5H syndrome and their etiopathogenesis]. (7725646)
1995
49
Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete. (1644073)
1992
50
Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. (1509712)
1992

Variations for Metabolic Syndrome X

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Expression for genes affiliated with Metabolic Syndrome X

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Expression patterns in normal tissues for genes affiliated with Metabolic Syndrome X

Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

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Pathways related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SERPINE1, LEP, IGFBP1
29.7INS, INSR, SLC2A4
3
Show member pathways
9.7LPL, INS, PPARG
49.7LEP, INSR, INS
59.7IL6, SERPINE1, INS
6
Show member pathways
9.5INS, INSR, LEP, SLC2A4
79.5INSR, LEP, ADIPOQ, SLC2A4
8
Show member pathways
9.4ALB, PLIN1, LPL
9
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.4PPARG, ADIPOQ, LPL, PLIN1
10
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.4SLC2A4, IL6, INSR, INS
119.3INS, INSR, SERPINE1, IL6
129.3IL6, TNF, LEP
139.3LEP, TNF, ADIPOQ, SLC2A4
149.2IGFBP1, INS, ALB, NR3C1
159.2TNF, IL6, NR3C1
169.2NR3C1, IL6, TNF
179.2IGFBP1, INS, ALB, CRP
18
Show member pathways
9.0INS, INSR, TNF, ADIPOQ, SLC2A4
198.9PPARG, INS, INSR, ADIPOQ, PLIN1, SLC2A4
20
Show member pathways
8.8PPARG, INS, INSR, TNF, IL6
218.8IGFBP1, INS, INSR, LEP, IL6, NR3C1
22
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.7PPARG, INS, INSR, TNF, SERPINE1, SLC2A4
23
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
8.4INS, INSR, LEP, TNF, ADIPOQ, IL6
24
Show member pathways
8.3PPARG, INS, INSR, LEP, TNF, ADIPOQ
25
Show member pathways
8.3INS, INSR, LEP, TNF, IL6, NR3C1
26
Show member pathways
8.2PPARG, INS, LEP, TNF, ADIPOQ, LPL
27
Show member pathways
thioredoxin pathway37
8.0INS, INSR, TNF, SERPINE1, IL6, ALB
28
Show member pathways
7.8PPARG, LEP, TNF, ADIPOQ, FADS1, LPL
29
Show member pathways
7.4PPARG, INS, HSD11B1, FADS1, LPL, SRD5A1
307.2SLC2A4, PPARG, INS, LEP, TNF, SERPINE1

Compounds for genes affiliated with Metabolic Syndrome X

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Compounds related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 281)
idCompoundScoreTop Affiliating Genes
1glimepiride44 50 1211.3INS, PPARG, ADIPOQ, SERPINE1, SLC2A4, INSR
2glycerol 3-phosphate44 2510.1PLIN1, HSD11B1, ADIPOQ, LPL, SLC2A4, LEP
3aicar44 25 1211.0INSR, INS, LEP, PPARG, ADIPOQ, SLC2A4
4telmisartan44 29 1211.0PPARG, INS, CRP, LEP, ADIPOQ, ALB
5thiazolidinedione448.8SLC2A4, CRP, LPL, ADIPOQ, SERPINE1, LEP
611beta-hydroxysteroid448.8LEP, HSD11B1, ADIPOQ, SRD5A1, SLC2A4, NR3C1
7orlistat44 60 1210.7LEPQTL1, PPARG, LPL, ADIPOQ, INS, LEP
8losartan44 50 29 1211.7PPARG, LEP, SERPINE1, ADIPOQ, ALB, CRP
98-isoprostane448.7SERPINE1, TNF, LEP, INS, ADIPOQ, IL6
10bezafibrate44 29 1210.5CRP, SERPINE1, PPARG, INS, ADIPOQ, LPL
11triacylglycerol448.4PLIN1, LPL, ADIPOQ, SERPINE1, LEPQTL1, LEP
12dihydrotestosterone44 29 25 1211.4NR3C1, SRD5A1, SERPINE1, LEP, LPL, INSR
13rapamycin448.2IGFBP1, PPARG, SLC2A4, CRP, LEP, NR3C1
14androstenedione44 259.2IGFBP1, INS, SRD5A1, LEPQTL1, LEP, HSD11B1
15c-peptide448.2CRP, ADIPOQ, SERPINE1, LEPQTL1, LEP, INSR
16dhea448.1NR3C1, SRD5A1, ADIPOQ, HSD11B1, LEPQTL1, LEP
17uric acid44 259.1LEP, ADIPOQ, ALB, INS, CRP, LEPQTL1
18pravastatin44 50 29 25 1212.0LEP, CRP, IL6, LPL, ADIPOQ, PPARG
19sb 20358044 608.9SERPINE1, CRP, SLC2A4, NR3C1, PPARG, INSR
20thyroxine44 258.8PPARG, INS, ALB, LPL, IGFBP1, ADIPOQ
21simvastatin44 50 60 29 25 1212.8IL6, CRP, TNF, SERPINE1, LPL, FADS1
22fenofibrate44 50 129.8PPARG, INS, INSR, LEP, CRP, IL6
23indomethacin44 29 60 1210.7SLC2A4, ALB, IL6, SRD5A1, LPL, TNF
24vitamin d447.7INSR, IGFBP1, PPARG, SERPINE1, ADIPOQ, LPL
25norepinephrine44 25 129.6ADIPOQ, LEPQTL1, LEP, INS, IGFBP1, LPL
26hydrocortisone44 3 60 1210.6INS, TNF, NR3C1, IGFBP1, INSR, LEPQTL1
27glycerol44 25 129.6LPL, ADIPOQ, HSD11B1, LEPQTL1, LEP, INSR
28estrone44 29 25 1210.6IGFBP1, LEP, LEPQTL1, ADIPOQ, LPL, SRD5A1
29genistein44 29 60 3 25 1212.5SLC2A4, INSR, LPL, SRD5A1, IL6, IGFBP1
30prednisolone44 29 129.5IGFBP1, TNF, HSD11B1, IL6, ALB, CRP
31ly294002447.5SERPINE1, INS, TNF, ADIPOQ, IL6, CRP
32metformin44 50 129.4PPARG, IGFBP1, INS, INSR, SLC2A4, CRP
33cycloheximide447.4PPARG, LEP, TNF, SERPINE1, IGFBP1, LPL
34estradiol44 25 129.3LEP, LEPQTL1, HSD11B1, IGFBP1, SERPINE1, SRD5A1
35methotrexate50 44 129.3ALB, CRP, IL6, ADIPOQ, SERPINE1, TNF
36troglitazone44 29 60 1210.2PPARG, INS, INSR, LEP, SLC2A4, IL6
37creatinine447.2LEPQTL1, LEP, INSR, INS, IGFBP1, SERPINE1
38pioglitazone29 44 50 1210.2SLC2A4, CRP, IL6, LPL, ADIPOQ, SERPINE1
39fibrinogen447.1CRP, ALB, IL6, ADIPOQ, SERPINE1, TNF
40alanine446.9INS, PPARG, IGFBP1, INSR, LEPQTL1, HSD11B1
41fatty acid446.8SLC2A4, ALB, PLIN1, LPL, FADS1, ADIPOQ
42lactate446.8SLC2A4, NR3C1, CRP, ALB, IL6, LPL
43estrogen446.6PPARG, LEP, INSR, INS, HSD11B1, SERPINE1
44vegf446.5CRP, IL6, SRD5A1, PPARG, NR3C1, IGFBP1
45glucose446.1PPARG, IL6, PLIN1, ALB, CRP, SLC2A4
46cholesterol44 29 25 129.0LEP, INS, IGFBP1, PPARG, LEPQTL1, HSD11B1
47rosiglitazone29 44 50 25 129.9HSD11B1, TNF, LEPQTL1, LEP, INSR, INS
48dexamethasone44 50 29 128.9IGFBP1, TNF, HSD11B1, SERPINE1, ADIPOQ, LPL
49testosterone44 60 25 128.5HSD11B1, LEPQTL1, LEP, INSR, INS, IGFBP1
50lipid444.9PPARG, IGFBP1, INS, INSR, LEP, LEPQTL1

GO Terms for genes affiliated with Metabolic Syndrome X

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Cellular components related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3INS, LEP, TNF, SERPINE1, ADIPOQ, LPL
2extracellular spaceGO:0056157.0CRP, IGFBP1, INS, LEP, TNF, SERPINE1

Biological processes related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:00267410.4PPARG, INS
2positive regulation of insulin receptor signaling pathwayGO:04662810.4INS, LEP
3positive regulation of respiratory burstGO:06026710.3INSR, INS
4positive regulation of developmental growthGO:04863910.3INSR, LEP
5positive regulation of STAT protein import into nucleusGO:200036610.3IL6, LEP
6negative regulation of smooth muscle cell migrationGO:01491210.2SERPINE1, ADIPOQ
7regulation of gluconeogenesisGO:00611110.2LEP, NR3C1
8positive regulation of cellular protein metabolic processGO:03227010.2INS, ADIPOQ
9positive regulation of glycolytic processGO:04582110.2INS, INSR
10brown fat cell differentiationGO:05087310.2ADIPOQ, SLC2A4, PPARG
11negative regulation of hormone secretionGO:04688810.2ADIPOQ, IL6
12fatty acid oxidationGO:01939510.1ADIPOQ, PPARG
13response to caffeineGO:03100010.1PPARG, IL6
14positive regulation of glucose importGO:04632610.1INSR, INS, ADIPOQ
15negative regulation of gluconeogenesisGO:04572110.1INS, ADIPOQ, IL6
16positive regulation of glycogen biosynthetic processGO:04572510.0INS, INSR
17positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0INS, ADIPOQ, IL6
18negative regulation of macrophage derived foam cell differentiationGO:01074510.0ADIPOQ, PPARG, CRP
19leukocyte tethering or rollingGO:05090110.0LEP, TNF
20response to sucroseGO:00974410.0FADS1, ADIPOQ
21positive regulation of DNA replicationGO:04574010.0INSR, INS, IL6
22response to coldGO:00940910.0LPL, PPARG, IL6
23activation of protein kinase B activityGO:0321489.9INS, INSR
24epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9TNF, IL6
25response to ethanolGO:0454719.9ADIPOQ, SLC2A4, CRP
26acute-phase responseGO:0069539.9CRP, IL6, INS
27cellular response to insulin stimulusGO:0328699.9SLC2A4, ADIPOQ, INSR, PPARG
28negative regulation of lipid catabolic processGO:0509959.9INS, TNF
29response to nutrientGO:0075849.8ALB, PPARG, ADIPOQ
30positive regulation of mitosisGO:0458409.8TNF, INSR, INS
31regulation of insulin secretionGO:0507969.8LEP, TNF, INS
32positive regulation of MAPK cascadeGO:0434109.8INSR, INS, LEP, IL6
33negative regulation of fat cell differentiationGO:0455999.7IL6, ADIPOQ, TNF
34response to glucocorticoidGO:0513849.7ADIPOQ, TNF, IL6
35glucose metabolic processGO:0060069.7ADIPOQ, TNF, INS, LEP
36glucose homeostasisGO:0425939.7SLC2A4, PPARG, INS, INSR, ADIPOQ
37response to insulinGO:0328689.6FADS1, LEP, IL6
38negative regulation of lipid storageGO:0108889.6TNF, IL6, CRP
39positive regulation of protein phosphorylationGO:0019349.6TNF, INSR, ADIPOQ
40positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6IL6, PPARG, TNF
41response to vitamin AGO:0331899.6FADS1, PPARG
42defense response to Gram-positive bacteriumGO:0508309.6CRP, TNF, IL6
43positive regulation of nitric oxide biosynthetic processGO:0454299.5INS, INSR, TNF, IL6
44positive regulation of protein kinase B signalingGO:0518979.5INSR, TNF, IL6, INS
45positive regulation of chemokine productionGO:0327229.5IL6, TNF
46response to hypoxiaGO:0016669.5CRP, ADIPOQ, LEP, TNF
47response to drugGO:0424939.3TNF, IL6, PPARG, LPL
48agingGO:0075689.2CRP, FADS1, IL6
49positive regulation of NF-kappaB transcription factor activityGO:0510929.1INS, TNF, IL6
50small molecule metabolic processGO:0442818.1HSD11B1, SRD5A1, INS, SLC2A4, PLIN1, ALB

Molecular functions related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.9INSR, INS
2hormone activityGO:0051799.5ADIPOQ, LEP, INS
3protease bindingGO:0020209.4INS, TNF, SERPINE1
4protein bindingGO:0055156.6SLC2A4, PPARG, INS, INSR, TNF, SERPINE1

Products for genes affiliated with Metabolic Syndrome X

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
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Sources for Metabolic Syndrome X

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet