AOMS1
MCID: MTB001
MIFTS: 56

Metabolic Syndrome X (AOMS1) malady

Rare diseases category
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Summaries for Metabolic Syndrome X

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Metabolic Syndrome X, also known as abdominal obesity-metabolic syndrome, is related to coronary artery disease and polycystic ovary syndrome. An important gene associated with Metabolic Syndrome X is AOMS1 (Abdominal obesity-metabolic syndrome QTL1), and among its related pathways are FoxO signaling pathway and Arf6 trafficking events. The drugs magnesium hydroxide and milk of magnesia and the compounds ribonucleic acid and cortisone have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are cardiovascular system and adipose tissue.

Wikipedia:65 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of... more...

Description from OMIM:47 605552

Aliases & Classifications for Metabolic Syndrome X

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Sources:
8Disease Ontology, 65Wikipedia, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 35MeSH, 40NCIt, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

metabolic syndrome x 8 43 22 10 45 62
abdominal obesity-metabolic syndrome 8 47
abdominal obesity metabolic syndrome 43 62
metabolic disorders 65 34
metabolic syndrome 8 34
dysmetabolic syndrome x 8
metabolic diseases 62
metabolic disorder 45
aoms1 43


External Ids:

Disease Ontology8 DOID:14221
ICD9CM27 277.7
MeSH35 D024821
NCIt40 C84442
OMIM47 605552

Related Diseases for Metabolic Syndrome X

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Metabolic Syndrome X family:

Acquired Metabolic Disease

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 978)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease30.8IGFBP1, INS, SERPINE1
2polycystic ovary syndrome30.8INS, IGFBP1
3fatty liver disease30.8INS, SERPINE1
4lipodystrophy30.7HSD11B1, INS
5hypertriglyceridemia30.5SLC2A4, SERPINE1, INS
6hypertension30.5SERPINE1, HSD11B1, INS
7glucose intolerance30.5SLC2A4, SERPINE1, INS, IGFBP1
8obesity30.5IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
9insulin resistance30.5IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
10gestational diabetes30.5SLC2A4, INS, IGFBP1
11essential hypertension30.4SERPINE1, INS
12hypercholesterolemia30.3SERPINE1, INS
13hyperandrogenism30.2IGFBP1, INS
14atherosclerosis30.2INS, HSD11B1, SERPINE1
15growth hormone deficiency30.1INS, IGFBP1
16diabetes mellitus30.1IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
17breast cancer30.1SLC2A4, SERPINE1, INS, IGFBP1
18cushing's syndrome30.1HSD11B1, IGFBP1
19acute myocardial infarction30.0IGFBP1, SERPINE1
20diabetic nephropathy29.9SERPINE1, INS
21hyperglycemia29.9IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
22type 2 diabetes mellitus29.9IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4
23acromegaly29.7IGFBP1, INS, HSD11B1
24familial hyperlipidemia29.7SERPINE1, HSD11B1, INS
25adenoma29.7IGFBP1, INS, HSD11B1
26hyperinsulinism29.6IGFBP1, INS, SERPINE1
27endotheliitis10.6
28artery disease10.6
29liver disease10.6
30hyperuricemia10.5
31lipid metabolism disorder10.5
32hepatitis10.5
33kidney disease10.5
34hypogonadism10.4
35psoriasis10.4
36schizophrenia10.4
37nephrolithiasis10.3
38sleep apnea10.3
39carbohydrate metabolic disorder10.3
40obstructive sleep apnea10.3
41cerebritis10.3
42arthritis10.3
43glycogen storage disease iv10.3
44periodontitis10.3
45galactosemia10.3
46morbid obesity10.3
47prostatitis10.3
48nonalcoholic steatohepatitis10.3
49familial combined hyperlipidemia10.2
50cystinuria10.2

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Symptoms for Metabolic Syndrome X

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Sources:
47OMIM
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Clinical features from OMIM:

605552

Drugs & Therapeutics for Metabolic Syndrome X

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Metabolic Syndrome X

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Sources:
22GTR
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Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X22

Anatomical Context for Metabolic Syndrome X

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33MalaCards
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MalaCards organs/tissues related to Metabolic Syndrome X:

33
Heart, Kidney, Brain, Liver, Pituitary

Animal Models for Metabolic Syndrome X or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Metabolic Syndrome X:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4SLC2A4, SERPINE1, HSD11B1, INS
2MP:00053758.3INS, HSD11B1, SERPINE1, SLC2A4
3MP:00053707.5SLC2A4, SERPINE1, HSD11B1, INS, IGFBP1
4MP:00053877.2IGFBP1, INS, HSD11B1, SERPINE1, SLC2A4

Publications for Metabolic Syndrome X

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Sources:
52PubMed
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Articles related to Metabolic Syndrome X:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. (23923606)
2013
2
Anaesthetic considerations in metabolic syndrome X. (20532086)
2010
3
Central retinal artery occlusion in a patient with metabolic syndrome x. (22737328)
2010
4
Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. (19374165)
2009
5
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
6
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? (17475465)
2007
7
Cardiac syndrome X versus metabolic syndrome X. (17010457)
2007
8
Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. (16999025)
2006
9
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X. (16416266)
2006
10
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. (15734832)
2005
11
Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)
2005
12
HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure. (15470277)
2004
13
Metabolic syndrome X: an inflammatory condition? (14972097)
2004
14
Low-flow vascular remodeling in the metabolic syndrome X. (14644764)
2004
15
Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)
2003
16
Metabolic syndrome X is common in Indians: but, why and how? (14719590)
2003
17
The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)
2003
18
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. (12756274)
2003
19
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. (12697574)
2003
20
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. (15028595)
2003
21
Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. (12781862)
2003
22
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)
2003
23
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)
2003
24
Metabolic syndrome X--high risk factor for acute myocardial infarction and its complications. (12137304)
2002
25
Molecular mechanism of vascular disease in metabolic syndrome X. (11872360)
2002
26
The metabolic syndrome X and peripheral cortisol synthesis. (12397528)
2002
27
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. (12512799)
2002
28
Metabolic syndrome X is common in South Asians, but why and how? (12297221)
2002
29
Obesity, metabolic syndrome X, and inflammation. (11985951)
2002
30
Is metabolic syndrome X an inflammatory condition? (12486208)
2002
31
Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. (11958275)
2001
32
Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. (15573024)
2001
33
Steroid metabolism in metabolic syndrome X. (11469814)
2001
34
Metabolic syndrome X and fibrinolytic disturbances. (10870268)
2000
35
Metabolic syndrome X: a review. (10863169)
2000
36
Insulin resistance: the metabolic syndrome X (10713753)
2000
37
Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine. (11057441)
2000
38
The metabolic syndrome X. (10842649)
1999
39
Hypothalamic origin of the metabolic syndrome X. (10842670)
1999
40
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
41
Liver pathology and the metabolic syndrome X in severe obesity. (10323371)
1999
42
Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. (10189006)
1999
43
Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)
1998
44
Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)
1998
45
Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)
1998
46
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)
1997
47
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)
1996
48
Clinical manifestations of the insulin resistance syndrome. The hormonal-metabolic syndrome X, the 5H syndrome and their etiopathogenesis]. (7725646)
1995
49
Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete. (1644073)
1992
50
Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. (1509712)
1992

Variations for Metabolic Syndrome X

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Expression for genes affiliated with Metabolic Syndrome X

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Metabolic Syndrome X

Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 51PharmGKB, 12EMD Millipore, 60Thomson Reuters, 55Reactome
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Pathways related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.3SLC2A4, INS
29.3SLC2A4, INS
3
Show member pathways
9.3INS, SLC2A4
49.3SLC2A4, INS
59.3SERPINE1, INS
69.3SERPINE1, INS
7
Show member pathways
thioredoxin pathway38
9.3INS, SERPINE1
89.1SERPINE1, IGFBP1
99.0INS, IGFBP1
109.0INS, IGFBP1
119.0INS, IGFBP1
128.8SLC2A4, SERPINE1, INS
13
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.8INS, SERPINE1, SLC2A4

Compounds for genes affiliated with Metabolic Syndrome X

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1ribonucleic acid459.8SLC2A4, HSD11B1
2cortisone45 2410.7INS, HSD11B1
3repaglinide51 45 1111.7INS, SERPINE1
4ramipril45 1110.7INS, SERPINE1
5gliclazide45 51 1111.7SLC2A4, INS
6cyproteroneacetate459.6INS, SERPINE1
7ciglitazone45 2910.6SERPINE1, SLC2A4
8gemfibrozil29 45 1111.6SERPINE1, INS
911beta-hydroxysteroid459.5SLC2A4, HSD11B1
108-isoprostane459.4SERPINE1, INS
11fructosamine45 2410.4IGFBP1, INS
12beta-hydroxybutyrate459.4IGFBP1, INS
13clomiphene citrate459.4INS, IGFBP1
14bezafibrate45 29 1111.3INS, SERPINE1
15glimepiride45 51 1111.3SLC2A4, INS, SERPINE1
16sulfonylurea459.3SERPINE1, SLC2A4, INS
17thiazolidinedione459.2SERPINE1, INS, SLC2A4
18aicar45 24 1111.2SLC2A4, INS
19troglitazone45 29 61 1112.2INS, SLC2A4, SERPINE1
20phosphoenolpyruvate45 1110.1IGFBP1, HSD11B1, SLC2A4
21ly294002459.0INS, SLC2A4, SERPINE1
22dhea459.0IGFBP1, INS, HSD11B1
23androstenedione45 2410.0INS, IGFBP1, HSD11B1
24hydrocortisone45 3 61 1112.0IGFBP1, INS, HSD11B1
25acth458.9HSD11B1, INS, IGFBP1
26chloramphenicol45 3 51 1111.9SERPINE1, IGFBP1, SLC2A4
272-deoxyglucose45 119.9IGFBP1, SLC2A4, INS
28c-peptide458.9INS, SERPINE1, IGFBP1
29gnrh458.9IGFBP1, SERPINE1, INS
30fibrinogen458.8SERPINE1, INS, IGFBP1
31norepinephrine45 24 1110.8INS, SLC2A4, IGFBP1
32actinomycin d458.8SLC2A4, SERPINE1, IGFBP1
33rapamycin458.8INS, SLC2A4, IGFBP1
34estradiol45 24 1110.7SERPINE1, HSD11B1, IGFBP1
35progesterone45 29 61 24 1112.5IGFBP1, HSD11B1, SERPINE1, SLC2A4
36glycerol45 24 1110.5SLC2A4, INS, HSD11B1, IGFBP1
37glycogen45 249.5HSD11B1, SLC2A4, INS, IGFBP1
38fatty acid458.5IGFBP1, INS, SLC2A4, HSD11B1
39metformin45 51 1110.4IGFBP1, SLC2A4, INS, SERPINE1
40cholesterol45 29 24 1111.4SERPINE1, INS, IGFBP1, HSD11B1
41alanine458.4SLC2A4, HSD11B1, IGFBP1, INS
42creatinine458.4SLC2A4, SERPINE1, INS, IGFBP1
43forskolin45 51 1110.4SLC2A4, IGFBP1, HSD11B1
44estrogen458.3IGFBP1, HSD11B1, SERPINE1, INS
45pioglitazone29 45 51 1111.0IGFBP1, HSD11B1, SLC2A4, SERPINE1, INS
46rosiglitazone29 45 51 24 1112.0HSD11B1, SERPINE1, IGFBP1, SLC2A4, INS
47testosterone45 61 24 1111.0SLC2A4, SERPINE1, HSD11B1, INS, IGFBP1
48dexamethasone45 51 29 1111.0HSD11B1, SLC2A4, INS, SERPINE1, IGFBP1
49glucose458.0INS, IGFBP1, SLC2A4, SERPINE1, HSD11B1
50lipid457.9HSD11B1, SERPINE1, INS, SLC2A4, IGFBP1

GO Terms for genes affiliated with Metabolic Syndrome X

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16Gene Ontology
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Biological processes related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:0425939.3SLC2A4, INS
2glucose transportGO:0157589.2SLC2A4, INS
3positive regulation of cell growthGO:0303078.7INS, IGFBP1

Molecular functions related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3SERPINE1, INS

Products for genes affiliated with Metabolic Syndrome X

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Metabolic Syndrome X

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet