Metabolic Syndrome X malady

MalaCards: Metabolic Syndrome X, also known as abdominal obesity-metabolic syndrome, is related to stickler syndrome and insulin resistance. An important gene associated with Metabolic Syndrome X is LSL (Leptin, serum levels of), and among its related pathways are Aldosterone-regulated sodium reabsorption and PGC1Alpha Pathway. The compounds rapamycin and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include heart, adipocyte and liver, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Descriptions:

metabolic syndrome x 6 30 8 32 43 abdominal obesity-metabolic syndrome 6 7 33 abdominal obesity metabolic syndrome 30 43

metabolic syndrome x (disorder) 6 dysmetabolic syndrome x 6 aoms1 30

Disease types for metabolic disorders family:

metabolic syndrome x

Diseases related to metabolic syndrome x by text searches and GeneDecks gene sharing:

(show top 50)    (show all 558)

id	Related Disease	Score	Top Affiliating Genes
1	stickler syndrome	28.7	INS, IL6, IGFBP1, TNF, CRP
2	insulin resistance	22.6	SERPINE1, LPL, LEP, INS, INSR, IL6
3	atherosclerosis	21.8	SERPINE1, LPL, LEP, INS, INSR, IL6
4	diabetes mellitus	20.5	SERPINE1, LPL, LEP, INS, INSR, IL6
5	hypertension	20.4	SERPINE1, LPL, LEP, INS, INSR, IL6
6	obesity	19.9	SERPINE1, LPL, LEP, INS, INSR, IL6
7	acdc	13.6	PPARG, ADIPOQ
8	overnutrition	13.5	LEP, INS
9	hyperproinsulinemia	13.5	INS, IGFBP1
10	combined hyperlipemia	13.5	LPL, INS
11	lipid metabolism disorder	13.5	LPL, INS
12	carbohydrate metabolic disorder	13.5	INS, PPARG
13	bulimia nervosa	13.5	LEP, LSL
14	insulin autoimmune syndrome	13.4	INS, INSR
15	sleep apnea	13.4	LEP, LSL, ADIPOQ
16	hypothyroidism	13.4	LEP, LSL, ADIPOQ
17	congenital generalized lipodystrophy	13.4	LEP, INS, LSL
18	skin tag	13.4	LEP, INS, LSL
19	prediabetes syndrome	13.4	INS, PPARG, ADIPOQ
20	leptin deficiency	13.3	LEP, PPARG, LSL
21	hypertensive retinopathy	13.3	ALB, ADIPOQ
22	mandibuloacral dysplasia	13.3	INS, PPARG
23	familial partial lipodystrophy	13.3	LEP, INS, PPARG
24	donohue syndrome	13.3	INS, INSR
25	marasmus	13.3	ALB, LSL
26	resting heart rate	13.3	INS, FADS1, LSL
27	ketoacidosis due to scot deficiency	13.3	INS, INSR, LSL
28	hypogonadotropism	13.3	LEP, INS, LSL
29	diabetic angiopathy	13.3	SERPINE1, LEP, INS
30	hypouricemia	13.2	INS, ALB
31	fragile x-associated primary ovarian insufficiency	13.2	INSR, IGFBP1
32	neonatal stroke	13.2	SERPINE1, ALB
33	rabson-mendenhall syndrome	13.2	LEP, INS, INSR
34	fetal macrosomia	13.2	LEP, INS, INSR
35	laron syndrome	13.2	INS, IGFBP1, LSL, ADIPOQ
36	hyperaldosteronism	13.2	INS, INSR, LSL
37	adult dermatomyositis	13.2	INS, TNF
38	familial combined hyperlipidemia	13.2	LPL, INS, LSL, ADIPOQ
39	lymphangitis	13.2	SERPINE1, ALB
40	amenorrhea	13.2	LEP, INS, LSL, ADIPOQ
41	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.2	INS, ALB, SLC2A4
42	growth mental deficiency syndrome of myhre	13.1	LEP, SRD5A1, LSL
43	schizoaffective disorder	13.1	INS, PPARG, ADIPOQ
44	focal glomerulosclerosis	13.1	LPL, ALB
45	lipoatrophic diabetes	13.1	LEP, INS, PPARG, ADIPOQ
46	familial hyperlipidemia	13.1	LPL, INS, ALB
47	hypoaldosteronism	13.1	INS, IL6
48	thyrotoxicosis	13.1	LEP, INS, ALB
49	short limb dwarf edema iris coloboma	13.1	ALB, PPARG
50	tangier disease	13.0	LPL, ALB, PPARG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to metabolic syndrome x:

²²

MGI Mouse Phenotypes related to metabolic syndrome x:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.0	INSR, INS
2	respiratory system phenotype	MP:0005388	10.0	LPL, INSR
3	integument phenotype	MP:0010771	9.9	NR3C1, PLIN1
4	liver/biliary system phenotype	MP:0005370	8.8	LPL, INS, IL6, IGFBP1, HSD11B1, PLIN1
5	reproductive system phenotype	MP:0005389	8.4	ADIPOQ, SRD5A1, TNF, IL6, LEP
6	tumorigenesis	MP:0002006	8.3	PPARG, TNF, IL6, LEP, SERPINE1, ADIPOQ
7	immune system phenotype	MP:0005387	8.3	ADIPOQ, SLC2A4, NR3C1, TNF, FADS1, IL6
8	mortality/aging	MP:0010768	8.0	SLC2A4, NR3C1, PPARG, FADS1, IL6, LEP
9	growth/size phenotype	MP:0005378	7.7	ADIPOQ, SLC2A4, PLIN1, NR3C1, IL6, INS
10	muscle phenotype	MP:0005369	7.6	ADIPOQ, SLC2A4, PLIN1, PPARG, TNF, IL6
11	behavior/neurological phenotype	MP:0005386	6.9	ADIPOQ, PLIN1, NR3C1, PPARG, TNF, HSD11B1
12	digestive/alimentary phenotype	MP:0005381	6.8	SLC2A4, NR3C1, TNF, ALB, FADS1, IL6
13	cellular phenotype	MP:0005384	6.5	ADIPOQ, NR3C1, PPARG, TNF, IGFBP1, FADS1
14	cardiovascular system phenotype	MP:0005385	6.5	ADIPOQ, SLC2A4, CRP, NR3C1, PPARG, TNF
15	adipose tissue phenotype	MP:0005375	6.5	IL6, HSD11B1, TNF, PPARG, NR3C1, PLIN1
16	homeostasis/metabolism phenotype	MP:0005376	4.8	TNF, PPARG, NR3C1, CRP, PLIN1, SLC2A4

Articles related to metabolic syndrome x:

(show all 24)

id	Title	Authors	Year	Affiliating Genes
1	The metabolic syndrome X or insulin resistance syndrome (17304724)	NikoliA8 A.... StanimiroviA8 V.	2007	INS
2	Aberrant expression of perilipins and 11-beta-HSD-1 as molecular signatures of metabolic syndrome X in south east Asians. (16941796)	Das U.N.	2006	HSD11B1, PLIN1
3	Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)	Das U.N.	2005	TNF, IL6, ADIPOQ
4	Metabolic syndrome X: an inflammatory condition? (14972097)	Das U.N.	2004	IL6, INS
5	The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)	Black P.H.	2003	IL6, CRP, INS
6	Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)	Barbagallo M.... Paolisso G.	2003	INSR
7	Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)	Cook S.... Scherrer U.	2003	LEP
8	Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)	Frontini M.G.... Berenson G.S.	2003	INS
9	Metabolic syndrome X is common in Indians: but, why and how? (14719590)	Das U.N.	2003	FADS1
10	The metabolic syndrome X and peripheral cortisol synthesis. (12397528)	BAohr V.... Diederich S.	2002	HSD11B1
11	Steroid metabolism in metabolic syndrome X. (11469814)	Walker B.R.	2001	SRD5A1
12	Metabolic syndrome X: a review. (10863169)	Timar O.... Levy E.	2000	SERPINE1
13	Hypothalamic origin of the metabolic syndrome X. (10842670)	BjAPrntorp P.... Rosmond R.	1999	NR3C1, INS
14	Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)	Matsuzawa Y.... Nakamura T.	1999	SERPINE1
15	Liver pathology and the metabolic syndrome X in sever e obesity. (10323371)	Marceau P.... Kral J.G.	1999	INS
16	Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)	Komers R.... Vrana A.	1998	INSR, PPARG, SLC2A4
17	Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)	Christensen J.O.... Christiansen C.	1998	SERPINE1, LEP, LSL
18	Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)	Gaspardone A.... Gioffre P.A.	1998	INS
19	NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)	Pickup J.C.... Burt D.	1997	IL6, ALB
20	Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)	Friedman T.C.... Chrousos G.P.	1996	INS
21	Clinical manifestations of the insulin resistance syndrome. The hormonal-metabolic syndrome X, the 5H syndrome and their etiopathogenesis (7725646)	Hrnciar J.	1995	INS
22	Hypertension, diabetes mellitus, atherosclerosis: cl inical manifestations of metabolic syndrome X. Prospects of pharmacological tre atment (7626978)	Moiseev V.S.... Kobalava Z.h.D.	1995	INS
23	Characteristics of the 'metabolic syndrome X' in a ca rdiovascular low risk population in Crete. (1644073)	Koutis A.D.... Lindholm L.H.	1992	INS
24	Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I (1509712)	Hrnciar J.... OkapcovA! J.	1992	INS

Genes related to metabolic syndrome x according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	LSL	Leptin, serum levels of	11.0	Publications
2	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	11.0	Publications
3	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	11.0	Publications
4	LEP	leptin	11.0	Publications
5	LPL	lipoprotein lipase	11.0
6	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
7	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
8	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
9	INS	insulin	11.0	Publications
10	IGFBP1	insulin-like growth factor binding protein 1	11.0
11	FADS1	fatty acid desaturase 1	11.0	Publications
12	PLIN1	perilipin 1	11.0	Publications
13	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
14	INSR	insulin receptor	11.0	Publications
15	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
16	TNF	tumor necrosis factor	11.0	Publications
17	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
18	ALB	albumin	11.0	Publications
19	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to metabolic syndrome x according to GeneDecks:

(show all 20)

id	Pathway	Score	Top Affiliating Genes
1	Aldosterone-regulated sodium reabsorption20	10.1	INS, HSD11B1
2	PGC1Alpha Pathway36	10.1	SLC2A4, INSR
3	Type II diabetes mellitus20	10.1	INS, SLC2A4, ADIPOQ
4	IRS activation38	10.0	INS, INSR
5	PPAR signaling pathway20	9.7	ADIPOQ, PLIN1, PPARG, LPL
6	Adipocytokine signaling pathway20	9.6	LEP, TNF, SLC2A4, ADIPOQ
7	AMPK Enzyme Complex Pathway36	9.5	SLC2A4, INSR, INS, LEP
8	Regulation of lipid metabolism_Insulin signaling-generic cascades41	9.5	SLC2A4, INSR, INS
9	Adipocytokines & Insulin Signaling37	9.5	LEP, INS, INSR, SLC2A4, ADIPOQ
10	Glucose / Energy Metabolism3	9.3	ADIPOQ, SLC2A4, PLIN1, PPARG, INSR
11	Regulation of lipid metabolism Insulin signaling-generic cascades10	9.3	SLC2A4, INSR, INS
12	Immune response IL-1 signaling pathway10	9.1	SERPINE1, IL6, TNF
13	Immune response MIF-mediated glucocorticoid regulation10	9.1	IL6, TNF, NR3C1
14	Immune response_MIF-mediated glucocorticoid regulation41	9.1	IL6, TNF, NR3C1
15	Immune response_IL-1 signaling pathway41	9.1	TNF, IL6, SERPINE1
16	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	NR3C1, TNF, IL6
17	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.9	IL6, TNF, NR3C1
18	Selected targets of HNF110	8.8	INS, IGFBP1, ALB, CRP
19	Selected targets of GCR-alpha10	8.5	NR3C1, IGFBP1, IL6, INSR, INS, LEP
20	Metabolism of lipids and lipoproteins38	8.5	PLIN1, SRD5A1, HSD11B1, ALB, FADS1, LPL

Compounds related to metabolic syndrome x according to GeneDecks:

(show top 50)    (show all 220)

id	Compound	Score	Top Affiliating Genes
1	rapamycin32 42	11.0	SLC2A4, ADIPOQ, INS
2	c-peptide32	9.8	ADIPOQ, LSL, INSR, LEP
3	palmitate32	9.7	PPARG, SLC2A4, ADIPOQ
4	orlistat32 42 9 9	12.4	ADIPOQ, PPARG, LPL, INS, LEP, LSL
5	testosterone32 9 18 9	12.4	LPL, INSR, IGFBP1, SRD5A1, LSL
6	glimepiride32 34 9 9	12.2	SLC2A4, INSR, SERPINE1, INS, PPARG, ADIPOQ
7	creatinine32	9.2	CRP, IGFBP1, ADIPOQ, SLC2A4, LSL, LEP
8	glycerol 3-phosphate32 18	10.1	LEP, HSD11B1, PPARG, PLIN1, LPL, SLC2A4
9	aicar32 42 9 18 9	13.0	LEP, INS, INSR, PPARG, SLC2A4, ADIPOQ
10	triacylglycerol32	9.0	ADIPOQ, INS, LEP, LPL, LSL, PLIN1
11	11beta-hydroxysteroid32	9.0	LEP, SRD5A1, HSD11B1, NR3C1, SLC2A4, ADIPOQ
12	pravastatin32 34 9 18 9	12.9	SERPINE1, ADIPOQ, IL6, LSL, CRP
13	androstenedione32 18	9.9	SRD5A1, IGFBP1, INS, HSD11B1, LEP, ADIPOQ
14	bezafibrate32 9 9	10.9	SERPINE1, LPL, CRP, INS, PPARG, ADIPOQ
15	estradiol32 9 18 9	11.9	SERPINE1, NR3C1, SRD5A1, HSD11B1, IGFBP1
16	fatty acid32	8.8	INS, LEP, FADS1, IGFBP1, SLC2A4, LSL
17	atorvastatin32 34 9 18 9	12.8	ADIPOQ, CRP, PPARG, LPL, TNF
18	thiazolidinedione32	8.7	LPL, ADIPOQ, SLC2A4, CRP, PPARG, INS
19	dhea32	8.6	HSD11B1, NR3C1, LSL, ADIPOQ, SRD5A1, IGFBP1
20	pioglitazone32 9 9	10.6	ADIPOQ, SLC2A4, PPARG, LPL, LEP, INS
21	ly29400232	8.6	CRP, IL6, SLC2A4, ADIPOQ, TNF, LEP
22	dehydroepiandrosterone sulfate32	8.6	ADIPOQ, INS, LSL, SRD5A1, IGFBP1, LEP
23	telmisartan32 9 9	10.5	ADIPOQ, LEP, CRP, PPARG, INS, ALB
24	dihydrotestosterone32 9 18 9	11.3	LEP, IGFBP1, SERPINE1, LPL, INSR, ADIPOQ
25	losartan32 34 9 9	11.2	SERPINE1, ALB, PPARG, LEP, ADIPOQ, CRP
26	estrone32 9 18 9	11.2	LPL, ADIPOQ, LSL, IGFBP1, LEP, ALB
27	8-isoprostane32	8.2	TNF, SERPINE1, LEP, INS, IL6, CRP
28	uric acid32 18	9.2	ADIPOQ, ALB, INS, CRP, LSL, LEP
29	glycerol32 9 18 9	11.0	ADIPOQ, SLC2A4, LSL, PLIN1, PPARG, HSD11B1
30	sb 20358032 42	9.0	SLC2A4, CRP, PPARG, ADIPOQ, TNF, IL6
31	thyroxine32 18	8.9	ALB, PPARG, INSR, LSL, ADIPOQ, INS
32	simvastatin32 34 42 9 18 9	12.8	SERPINE1, LPL, IL6, FADS1, TNF, PPARG
33	metformin32 34 9 9	10.8	ADIPOQ, SLC2A4, LSL, CRP, PPARG, IGFBP1
34	norepinephrine32 9 18 9	10.7	LSL, ADIPOQ, SLC2A4, PLIN1, CRP, IGFBP1
35	hydrocortisone32 9 9	9.7	IGFBP1, INSR, INS, ADIPOQ, LSL, NR3C1
36	troglitazone32 42 9 9	10.5	ADIPOQ, SERPINE1, LPL, LEP, INS, INSR
37	fenofibrate32 9 9	9.4	ADIPOQ, CRP, PPARG, IL6, INSR, INS
38	indomethacin32 9 9	9.2	LEP, SRD5A1, ALB, LPL, IL6, IGFBP1
39	prednisolone32 9 9	9.2	ALB, IL6, IGFBP1, HSD11B1, TNF, NR3C1
40	methotrexate32 34 42 9 9	11.1	CRP, TNF, ALB, LSL, IL6, LEP
41	vitamin d32	6.9	LPL, INSR, IL6, IGFBP1, ALB, SRD5A1
42	fibrinogen32	6.9	ALB, IGFBP1, CRP, TNF, LSL, ADIPOQ
43	cycloheximide32	6.8	SLC2A4, TNF, SERPINE1, CRP, NR3C1, PPARG
44	estrogen32	6.8	INS, INSR, SRD5A1, HSD11B1, IGFBP1, ADIPOQ
45	vegf32	6.5	LEP, INSR, NR3C1, PPARG, TNF, SRD5A1
46	lactate32	6.5	ADIPOQ, CRP, TNF, ALB, LSL, SLC2A4
47	rosiglitazone32 9 18 9	9.4	LSL, SLC2A4, ADIPOQ, CRP, PPARG, TNF
48	dexamethasone32 42 34 9 9	10.1	ADIPOQ, SLC2A4, LSL, NR3C1, PPARG, SRD5A1
49	cholesterol32 9 18 9	9.1	CRP, PPARG, PLIN1, LSL, ADIPOQ, HSD11B1
50	lipid32	4.9	SERPINE1, LPL, LEP, INS, INSR, IL6

Cellular components related to metabolic syndrome x according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.0	CRP, ALB, IGFBP1, IL6, INS, LEP
2	extracellular space	GO:005615	6.1	SERPINE1, ADIPOQ, CRP, TNF, ALB, IGFBP1

Biological processes related to metabolic syndrome x according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of insulin receptor signaling pathway	GO:046628	10.2	INS, LEP
2	negative regulation of gluconeogenesis	GO:045721	10.2	ADIPOQ, INS
3	positive regulation of developmental growth	GO:048639	10.1	INSR, LEP
4	brown fat cell differentiation	GO:050873	10.1	ADIPOQ, SLC2A4, PPARG
5	negative regulation of acute inflammatory response	GO:002674	10.1	PPARG, INS
6	positive regulation of respiratory burst	GO:060267	10.1	INSR, INS
7	negative regulation of smooth muscle cell migration	GO:014912	10.1	ADIPOQ, SERPINE1
8	regulation of gluconeogenesis	GO:006111	10.0	NR3C1, LEP
9	positive regulation of STAT protein import into nucleus	GO:2000366	10.0	IL6, LEP
10	positive regulation of glucose import	GO:046326	9.9	INS, INSR, ADIPOQ
11	negative regulation of macrophage derived foam cell differentiation	GO:010745	9.8	ADIPOQ, CRP, PPARG
12	leukocyte tethering or rolling	GO:050901	9.8	LEP, TNF
13	positive regulation of glycolysis	GO:045821	9.8	INS, INSR
14	cellular response to organic cyclic compound	GO:071407	9.7	PPARG, SRD5A1, TNF
15	positive regulation of mitosis	GO:045840	9.6	TNF, INSR, INS
16	positive regulation of nitric oxide biosynthetic process	GO:045429	9.6	TNF, INSR, INS
17	glucose metabolic process	GO:006006	9.6	LEP, INS, TNF, ADIPOQ
18	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	TNF, INSR, INS
19	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	INS, IL6, ADIPOQ
20	negative regulation of fat cell differentiation	GO:045599	9.5	ADIPOQ, TNF, IL6
21	regulation of insulin secretion	GO:050796	9.5	LEP, INS, TNF
22	response to activity	GO:014823	9.4	NR3C1, TNF, INSR
23	cellular response to insulin stimulus	GO:032869	9.4	ADIPOQ, SLC2A4, PPARG, SRD5A1, INSR
24	cellular response to starvation	GO:009267	9.3	FADS1, ALB, SRD5A1
25	acute-phase response	GO:006953	9.3	INS, IL6, CRP
26	positive regulation of MAPK cascade	GO:043410	9.3	LEP, INS, INSR, IL6
27	response to hypoxia	GO:001666	9.2	LEP, TNF, CRP, ADIPOQ
28	glucose homeostasis	GO:042593	9.2	SERPINE1, INS, INSR, PPARG, SLC2A4, ADIPOQ
29	negative regulation of lipid storage	GO:010888	9.2	IL6, TNF, CRP
30	lipid metabolic process	GO:006629	9.1	PLIN1, PPARG, ALB, LPL
31	positive regulation of protein phosphorylation	GO:001934	9.0	INSR, TNF, ADIPOQ
32	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	PPARG, TNF, IL6
33	response to glucocorticoid stimulus	GO:051384	8.8	ADIPOQ, TNF, IL6, INSR, SERPINE1
34	negative regulation of apoptotic process	GO:043066	8.1	TNF, ALB, IL6, INS, LEP, SERPINE1
35	small molecule metabolic process	GO:044281	8.0	SLC2A4, PLIN1, SRD5A1, HSD11B1, ALB, FADS1

Molecular functions related to metabolic syndrome x according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:002020	9.4	SERPINE1, INS, TNF