MCID: MTB001
MIFTS: 58

Metabolic Syndrome X malady

Rare diseases, Metabolic diseases categories

Summaries for Metabolic Syndrome X

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MedlinePlus:32 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Metabolic Syndrome X, also known as abdominal obesity metabolic syndrome, is related to hypertriglyceridemia and morbid obesity. An important gene associated with Metabolic Syndrome X is HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1), and among its related pathways are HIF-1-alpha transcription factor network and Insulin-mediated glucose transport. The drugs magnesium hydroxide and milk of magnesia and the compounds glimepiride and glycerol 3-phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are tumorigenesis and reproductive system.

Wikipedia:63 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of... more...

Aliases & Classifications for Metabolic Syndrome X

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Metabolic Syndrome X, Aliases & Descriptions:

Name: Metabolic Syndrome X 9 41 11 43 22 60
Abdominal Obesity Metabolic Syndrome 41 60
Metabolic Disorders 63 32
Metabolic Syndrome 9 32
Abdominal Obesity-Metabolic Syndrome 9
 
Dysmetabolic Syndrome X 9
Metabolic Disorder 43
Metabolic Diseases 60
Aoms1 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


External Ids:

Disease Ontology9 DOID:14221
ICD9CM27 277.7
NCIt38 C84442
MeSH33 D024821

Related Diseases for Metabolic Syndrome X

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Diseases in the Acquired Metabolic Disease family:

metabolic syndrome x

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1011)
idRelated DiseaseScoreTop Affiliating Genes
1hypertriglyceridemia31.2LPL, SERPINE1
2morbid obesity31.1LEP, INS
3hypogonadism31.0ADIPOQ, LEPQTL1, LEP, INS
4fatty liver disease31.0CRP, LEP, INS, PPARG
5obstructive sleep apnea31.0ADIPOQ, LEPQTL1, LEP
6coronary artery disease31.0CRP, LPL, SERPINE1, LEPQTL1
7polycystic ovary syndrome30.9SRD5A1, LEP, INSR, INS, IGFBP1
8schizophrenia30.8NR3C1, INSR, INS
9eating disorder30.7LEP, INS
10acquired generalized lipodystrophy30.6ADIPOQ, LEP
11arteriosclerosis30.6LPL, ADIPOQ, SERPINE1, PPARG
12acanthosis nigricans30.5ADIPOQ, LEP, INSR, INS
13hyperinsulinemic hypoglycemia30.5INS
14peripheral vascular disease30.5ALB, SERPINE1
15cushing's syndrome30.5NR3C1, HSD11B1, INS
16kidney disease30.4NR3C1, IL6, LPL, SERPINE1, TNF
17familial hyperlipidemia30.4LPL, INS
18hepatitis c30.4ADIPOQ, TNF, LEPQTL1
19vascular disease30.4IL6, TNF
20hypothyroidism30.3LEPQTL1, LEP, INS
21arthritis30.3IL6, TNF
22aortic aneurysm30.3CRP
23lipodystrophy30.3LPL, ADIPOQ, HSD11B1, LEPQTL1, LEP, INSR
24diabetic ketoacidosis30.3LEPQTL1, INS
25growth hormone deficiency30.2ADIPOQ, LEPQTL1, LEP, INS, IGFBP1
26prader-willi syndrome30.2ADIPOQ, LEPQTL1, LEP, INS
27ovarian disease30.2INSR, IGFBP1
28infertility30.2LEPQTL1, LEP, INS, IGFBP1
29acute myocardial infarction30.2CRP, SERPINE1, IGFBP1
30hyperhomocysteinemia30.2CRP, ALB, SERPINE1
31periodontal disease30.2CRP, IL6, TNF
32tangier disease30.0LPL, PPARG
33anorexia nervosa30.0ADIPOQ, LEPQTL1, LEP, IGFBP1
34hyperlipidemia, familial combined30.0LPL, ADIPOQ, LEPQTL1, INS
35liver disease30.0CRP, ALB, IL6, TNF, LEP, INS
36myocardial infarction29.9CRP, ADIPOQ, SERPINE1, LEPQTL1, IGFBP1
37congenital adrenal hyperplasia29.9NR3C1, SRD5A1, LEPQTL1
38adenoma29.8SRD5A1, HSD11B1, INSR, INS, IGFBP1, PPARG
39acromegaly29.8ADIPOQ, HSD11B1, LEPQTL1, LEP, INS, IGFBP1
40familial mediterranean fever, ar29.8CRP, TNF
41osteoporosis29.8NR3C1, IL6, HSD11B1, LEPQTL1, LEP
42adenocarcinoma29.7SLC2A4, NR3C1, SRD5A1, HSD11B1, INSR, IGFBP1
43protein-energy malnutrition29.7ALB, LEPQTL1, LEP, IGFBP1
44nephrotic syndrome29.6NR3C1, ALB, LPL
45liver cirrhosis29.6SLC2A4, ALB, ADIPOQ, LEPQTL1, INSR
46pancreatitis29.6CRP, ALB, IL6, LPL, INS
47amyloidosis29.6CRP, ALB, LPL
48prostate cancer29.6NR3C1, IL6, SRD5A1, LPL, INSR, IGFBP1
49hyperandrogenism29.5NR3C1, SRD5A1, ADIPOQ, LEPQTL1, LEP, INSR
50osteoarthritis29.5NR3C1, CRP, IL6, HSD11B1, TNF

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Symptoms for Metabolic Syndrome X

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Drugs & Therapeutics for Metabolic Syndrome X

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Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Metabolic Syndrome X

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Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X22

Anatomical Context for Metabolic Syndrome X

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MalaCards organs/tissues related to Metabolic Syndrome X:

31
Heart, Kidney, Brain, Liver, Pituitary

Animal Models for Metabolic Syndrome X or affiliated genes

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MGI Mouse Phenotypes related to Metabolic Syndrome X:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1PPARG, LEP, TNF, SERPINE1, ADIPOQ, IL6
2MP:00053898.0INS, INSR, LEP, TNF, SRD5A1, NR3C1
3MP:00053678.0PPARG, INS, INSR, LEP, SERPINE1, ADIPOQ
4MP:00053908.0PPARG, INS, LEP, TNF, ADIPOQ, IL6
5MP:00053887.9INSR, LEP, TNF, HSD11B1, SERPINE1, ADIPOQ
6MP:00036317.7PPARG, INS, INSR, LEP, TNF, HSD11B1
7MP:00107717.7PPARG, INS, LEP, TNF, SERPINE1, ADIPOQ
8MP:00053867.5LEP, INSR, INS, PPARG, TNF, HSD11B1
9MP:00053817.4INS, INSR, LEP, TNF, FADS1, IL6
10MP:00053757.1NR3C1, PLIN1, IL6, LPL, ADIPOQ, SERPINE1
11MP:00053977.0PPARG, INS, INSR, LEP, TNF, HSD11B1
12MP:00053787.0PPARG, INS, INSR, LEP, TNF, HSD11B1
13MP:00053856.9TNF, LEP, INSR, INS, PPARG, HSD11B1
14MP:00053796.9PPARG, INS, INSR, LEP, TNF, HSD11B1
15MP:00053696.8TNF, LEP, INSR, INS, PPARG, HSD11B1
16MP:00053846.7LEP, INSR, INS, IGFBP1, PPARG, TNF
17MP:00053706.4SLC2A4, PPARG, IGFBP1, NR3C1, ALB, PLIN1
18MP:00053876.3TNF, LEP, INSR, INS, IGFBP1, PPARG
19MP:00107686.3TNF, LEP, INSR, INS, PPARG, SERPINE1
20MP:00053765.6SERPINE1, HSD11B1, TNF, LEP, INSR, INS

Publications for Metabolic Syndrome X

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Articles related to Metabolic Syndrome X:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. (23923606)
2013
2
Anaesthetic considerations in metabolic syndrome X. (20532086)
2010
3
Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. (19374165)
2009
4
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
5
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? (17475465)
2007
6
Cardiac syndrome X versus metabolic syndrome X. (17010457)
2007
7
Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. (16999025)
2006
8
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X. (16416266)
2006
9
Aberrant expression of perilipins and 11-beta-HSD-1 as molecular signatures of metabolic syndrome X in south east Asians. (16941796)
2006
10
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. (15734832)
2005
11
Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)
2005
12
HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure. (15470277)
2004
13
Metabolic syndrome X: an inflammatory condition? (14972097)
2004
14
Low-flow vascular remodeling in the metabolic syndrome X. (14644764)
2004
15
Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)
2003
16
Metabolic syndrome X is common in Indians: but, why and how? (14719590)
2003
17
The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)
2003
18
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. (12756274)
2003
19
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. (12697574)
2003
20
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. (15028595)
2003
21
Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. (12781862)
2003
22
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)
2003
23
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)
2003
24
Metabolic syndrome X--high risk factor for acute myocardial infarction and its complications. (12137304)
2002
25
Molecular mechanism of vascular disease in metabolic syndrome X. (11872360)
2002
26
The metabolic syndrome X and peripheral cortisol synthesis. (12397528)
2002
27
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. (12512799)
2002
28
Metabolic syndrome X is common in South Asians, but why and how? (12297221)
2002
29
Obesity, metabolic syndrome X, and inflammation. (11985951)
2002
30
Is metabolic syndrome X an inflammatory condition? (12486208)
2002
31
Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. (11958275)
2001
32
Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. (15573024)
2001
33
Steroid metabolism in metabolic syndrome X. (11469814)
2001
34
Metabolic syndrome X and fibrinolytic disturbances. (10870268)
2000
35
Metabolic syndrome X: a review. (10863169)
2000
36
Insulin resistance: the metabolic syndrome X (10713753)
2000
37
Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine. (11057441)
2000
38
The metabolic syndrome X. (10842649)
1999
39
Hypothalamic origin of the metabolic syndrome X. (10842670)
1999
40
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
41
Liver pathology and the metabolic syndrome X in severe obesity. (10323371)
1999
42
Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. (10189006)
1999
43
Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)
1998
44
Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)
1998
45
Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)
1998
46
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)
1997
47
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)
1996
48
Clinical manifestations of the insulin resistance syndrome. The hormonal-metabolic syndrome X, the 5H syndrome and their etiopathogenesis]. (7725646)
1995
49
Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete. (1644073)
1992
50
Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. (1509712)
1992

Variations for Metabolic Syndrome X

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Expression for genes affiliated with Metabolic Syndrome X

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Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

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Pathways related to Metabolic Syndrome X according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IGFBP1, LEP, SERPINE1
29.7INS, INSR, SLC2A4
3
Show member pathways
9.7LPL, INS, PPARG
49.7LEP, INSR, INS
5
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.7NR3C1, LEP, INS
69.7INS, SERPINE1, IL6
7
Show member pathways
9.5INS, INSR, LEP, SLC2A4
89.5INSR, LEP, ADIPOQ, SLC2A4
9
Show member pathways
9.4LPL, PLIN1, ALB
10
Show member pathways
fatty acid beta-oxidation VI (peroxisome)36
9.4PPARG, ADIPOQ, LPL, PLIN1
11
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.4SLC2A4, IL6, INSR, INS
129.3INS, INSR, SERPINE1, IL6
139.3IL6, TNF, LEP
149.3LEP, TNF, ADIPOQ, SLC2A4
159.2IGFBP1, INS, ALB, NR3C1
169.2NR3C1, IL6, TNF
179.2NR3C1, IL6, TNF
18
Show member pathways
9.0INS, INSR, TNF, ADIPOQ, SLC2A4
198.9PPARG, INS, INSR, ADIPOQ, PLIN1, SLC2A4
20
Show member pathways
8.8PPARG, INS, INSR, TNF, IL6
21
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
8.7PPARG, INS, INSR, TNF, SERPINE1, SLC2A4
22
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.4INS, INSR, LEP, TNF, ADIPOQ, IL6
23
Show member pathways
8.3PPARG, INS, INSR, LEP, TNF, ADIPOQ
24
Show member pathways
8.3INS, INSR, LEP, TNF, IL6, NR3C1
25
Show member pathways
8.2PPARG, INS, LEP, TNF, ADIPOQ, LPL
26
Show member pathways
thioredoxin pathway36
8.0INS, INSR, TNF, SERPINE1, IL6, ALB
27
Show member pathways
7.8PPARG, LEP, TNF, ADIPOQ, FADS1, LPL
28
Show member pathways
7.4PPARG, INS, HSD11B1, FADS1, LPL, SRD5A1
297.2SLC2A4, PPARG, INS, LEP, TNF, SERPINE1

Compounds for genes affiliated with Metabolic Syndrome X

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Compounds related to Metabolic Syndrome X according to GeneCards Suite gene sharing:

(show top 50)    (show all 285)
idCompoundScoreTop Affiliating Genes
1glimepiride43 49 1211.3SLC2A4, SERPINE1, ADIPOQ, INSR, INS, PPARG
2glycerol 3-phosphate43 2410.1SLC2A4, LEP, ADIPOQ, PPARG, HSD11B1, LPL
3telmisartan43 28 1211.0INS, ADIPOQ, ALB, CRP, PPARG, LEP
4aicar43 24 1210.9INS, PPARG, INSR, LEP, ADIPOQ, SLC2A4
5bezafibrate43 28 1210.8INS, SERPINE1, ADIPOQ, LPL, CRP, PPARG
6thiazolidinedione438.8SLC2A4, CRP, LPL, ADIPOQ, SERPINE1, LEP
7orlistat43 59 1210.7PPARG, LPL, LEP, LEPQTL1, ADIPOQ, INS
88-isoprostane438.7CRP, IL6, ADIPOQ, SERPINE1, TNF, LEP
9losartan43 49 28 1211.7SERPINE1, LEP, SLC2A4, CRP, PPARG, ALB
1011beta-hydroxysteroid438.4NR3C1, SLC2A4, ADIPOQ, HSD11B1, LEP, SRD5A1
11triacylglycerol438.4SERPINE1, INS, LEP, LEPQTL1, ADIPOQ, LPL
12dihydrotestosterone43 28 24 1211.4NR3C1, SRD5A1, LPL, ADIPOQ, SERPINE1, LEP
13rapamycin438.3INSR, NR3C1, INS, LEP, PPARG, ADIPOQ
14androstenedione43 249.2IGFBP1, SRD5A1, ADIPOQ, HSD11B1, INS, LEP
15c-peptide438.2CRP, ADIPOQ, SERPINE1, LEPQTL1, LEP, INSR
16dhea438.1NR3C1, SRD5A1, ADIPOQ, HSD11B1, LEPQTL1, LEP
17uric acid43 249.0INS, LEP, SERPINE1, ADIPOQ, ALB, CRP
18pravastatin43 49 28 24 1212.0LPL, ADIPOQ, SERPINE1, LEPQTL1, LEP, PPARG
19sb 20358043 598.9SERPINE1, TNF, PPARG, INSR, ADIPOQ, IL6
20simvastatin43 49 59 28 24 1212.8ADIPOQ, LPL, IL6, CRP, SERPINE1, TNF
21fenofibrate43 49 129.8INS, PPARG, INSR, LEP, CRP, IL6
22thyroxine43 248.8PPARG, IGFBP1, INSR, LEP, LEPQTL1, ADIPOQ
23indomethacin43 28 59 1210.7PPARG, ALB, SLC2A4, IL6, SRD5A1, LPL
24estrone43 28 24 1210.7LPL, LEP, ADIPOQ, LEPQTL1, IGFBP1, SRD5A1
25vitamin d437.6PPARG, IGFBP1, NR3C1, ALB, IL6, SRD5A1
26norepinephrine43 24 129.6INS, IGFBP1, LEP, SLC2A4, CRP, PLIN1
27genistein43 28 59 2 24 1212.6SLC2A4, PPARG, IGFBP1, INSR, TNF, SERPINE1
28glycerol43 24 129.6INS, IGFBP1, PPARG, INSR, SLC2A4, PLIN1
29hydrocortisone43 2 59 1210.6IGFBP1, ADIPOQ, IL6, TNF, NR3C1, LEPQTL1
30ly294002437.5SLC2A4, NR3C1, CRP, PPARG, INSR, INS
31prednisolone43 28 129.5LEPQTL1, IGFBP1, HSD11B1, TNF, IL6, ALB
32metformin43 49 129.5SLC2A4, CRP, LPL, ADIPOQ, SERPINE1, LEPQTL1
33cycloheximide437.4LEP, SLC2A4, NR3C1, IL6, TNF, CRP
34estradiol43 24 129.3SRD5A1, ALB, LEP, NR3C1, ADIPOQ, SERPINE1
35methotrexate49 43 129.3TNF, LEPQTL1, SERPINE1, ADIPOQ, IL6, ALB
36troglitazone43 28 59 1210.2SLC2A4, IL6, LPL, ADIPOQ, SERPINE1, TNF
37creatinine437.2INSR, INS, IGFBP1, LEP, LEPQTL1, SLC2A4
38pioglitazone28 43 49 1210.2LPL, ADIPOQ, SERPINE1, HSD11B1, TNF, LEP
39fibrinogen437.1ALB, IL6, ADIPOQ, SERPINE1, TNF, LEPQTL1
40alanine436.9INS, LEPQTL1, INSR, HSD11B1, IGFBP1, PPARG
41fatty acid436.8LPL, FADS1, ADIPOQ, HSD11B1, LEPQTL1, LEP
42lactate436.8SLC2A4, NR3C1, CRP, ALB, IL6, LPL
43estrogen436.6PPARG, IGFBP1, INS, INSR, LEP, LEPQTL1
44vegf436.5LEPQTL1, LEP, INSR, IGFBP1, TNF, CRP
45glucose436.1HSD11B1, LEPQTL1, LEP, INSR, INS, IGFBP1
46cholesterol43 28 24 129.0INS, IGFBP1, PPARG, LEP, LEPQTL1, CRP
47rosiglitazone28 43 49 24 129.9SLC2A4, INS, IGFBP1, PPARG, INSR, LEP
48dexamethasone43 49 28 128.9ADIPOQ, SERPINE1, HSD11B1, TNF, LEPQTL1, LEP
49testosterone43 59 24 128.5NR3C1, CRP, SLC2A4, SERPINE1, PPARG, ADIPOQ
50lipid434.9SLC2A4, CRP, LEP, INSR, INS, IGFBP1

GO Terms for genes affiliated with Metabolic Syndrome X

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Cellular components related to Metabolic Syndrome X according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.3INS, LEP, TNF, SERPINE1, ADIPOQ, LPL
2extracellular spaceGO:00056157.0CRP, IGFBP1, INS, LEP, TNF, SERPINE1

Biological processes related to Metabolic Syndrome X according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:000267410.4INS, PPARG
2positive regulation of insulin receptor signaling pathwayGO:004662810.4INS, LEP
3positive regulation of respiratory burstGO:006026710.3INS, INSR
4positive regulation of developmental growthGO:004863910.3INSR, LEP
5positive regulation of STAT protein import into nucleusGO:0200036610.3LEP, IL6
6negative regulation of smooth muscle cell migrationGO:001491210.2SERPINE1, ADIPOQ
7regulation of gluconeogenesisGO:000611110.2LEP, NR3C1
8positive regulation of cellular protein metabolic processGO:003227010.2ADIPOQ, INS
9positive regulation of glycolytic processGO:004582110.2INS, INSR
10brown fat cell differentiationGO:005087310.2SLC2A4, ADIPOQ, PPARG
11negative regulation of hormone secretionGO:004688810.2ADIPOQ, IL6
12fatty acid oxidationGO:001939510.1PPARG, ADIPOQ
13response to caffeineGO:003100010.1PPARG, IL6
14positive regulation of glucose importGO:004632610.1INS, INSR, ADIPOQ
15negative regulation of gluconeogenesisGO:004572110.1INS, ADIPOQ, IL6
16positive regulation of glycogen biosynthetic processGO:004572510.0INS, INSR
17positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0INS, ADIPOQ, IL6
18negative regulation of macrophage derived foam cell differentiationGO:001074510.0PPARG, ADIPOQ, CRP
19leukocyte tethering or rollingGO:005090110.0LEP, TNF
20response to sucroseGO:000974410.0ADIPOQ, FADS1
21positive regulation of DNA replicationGO:004574010.0INS, INSR, IL6
22response to coldGO:000940910.0PPARG, LPL, IL6
23activation of protein kinase B activityGO:00321489.9INSR, INS
24epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.9IL6, TNF
25response to ethanolGO:00454719.9SLC2A4, CRP, ADIPOQ
26acute-phase responseGO:00069539.9INS, IL6, CRP
27cellular response to insulin stimulusGO:00328699.9PPARG, INSR, ADIPOQ, SLC2A4
28negative regulation of lipid catabolic processGO:00509959.9INS, TNF
29response to nutrientGO:00075849.8PPARG, ADIPOQ, ALB
30positive regulation of mitosisGO:00458409.8TNF, INSR, INS
31regulation of insulin secretionGO:00507969.8TNF, LEP, INS
32positive regulation of MAPK cascadeGO:00434109.8IL6, LEP, INSR, INS
33negative regulation of fat cell differentiationGO:00455999.7IL6, ADIPOQ, TNF
34response to glucocorticoidGO:00513849.7IL6, ADIPOQ, TNF
35glucose metabolic processGO:00060069.7ADIPOQ, TNF, LEP, INS
36glucose homeostasisGO:00425939.7SLC2A4, ADIPOQ, INSR, INS, PPARG
37response to insulinGO:00328689.6IL6, FADS1, LEP
38negative regulation of lipid storageGO:00108889.6CRP, IL6, TNF
39positive regulation of protein phosphorylationGO:00019349.6ADIPOQ, TNF, INSR
40positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.6IL6, TNF, PPARG
41response to vitamin AGO:00331899.6PPARG, FADS1
42defense response to Gram-positive bacteriumGO:00508309.6CRP, IL6, TNF
43positive regulation of nitric oxide biosynthetic processGO:00454299.5INS, INSR, TNF, IL6
44positive regulation of protein kinase B signalingGO:00518979.5IL6, TNF, INSR, INS
45positive regulation of chemokine productionGO:00327229.5TNF, IL6
46response to hypoxiaGO:00016669.5CRP, ADIPOQ, TNF, LEP
47response to drugGO:00424939.4PPARG, TNF, LPL, IL6
48agingGO:00075689.2CRP, IL6, FADS1
49positive regulation of NF-kappaB transcription factor activityGO:00510929.1IL6, TNF, INS
50small molecule metabolic processGO:00442818.1INS, HSD11B1, FADS1, LPL, SRD5A1, PLIN1

Molecular functions related to Metabolic Syndrome X according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.9INSR, INS
2hormone activityGO:00051799.5ADIPOQ, LEP, INS
3protease bindingGO:00020209.4INS, TNF, SERPINE1
4protein bindingGO:00055156.6SLC2A4, PPARG, INS, INSR, TNF, SERPINE1

Products for genes affiliated with Metabolic Syndrome X

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  • Antibodies
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Sources for Metabolic Syndrome X

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet