AOMS1
MCID: MTB001
MIFTS: 67

Metabolic Syndrome X (AOMS1) malady

Metabolic diseases category

Summaries for Metabolic Syndrome X

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Metabolic Syndrome X, also known as abdominal obesity-metabolic syndrome, is related to coronary artery disease and fatty liver disease. An important gene associated with Metabolic Syndrome X is AOMS1 (Abdominal obesity-metabolic syndrome QTL1), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and HIF-1-alpha transcription factor network. The drugs magnesium hydroxide and milk of magnesia and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:63 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of... more...

Description from OMIM:46 605552

Aliases & Classifications for Metabolic Syndrome X

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 46OMIM, 63Wikipedia, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

metabolic syndrome x 8 42 22 10 44 60
abdominal obesity-metabolic syndrome 8 46
abdominal obesity metabolic syndrome 42 60
metabolic disorders 63 33
metabolic syndrome 8 33
dysmetabolic syndrome x 8
metabolic diseases 60
metabolic disorder 44
aoms1 42


External Ids:

Disease Ontology8 DOID:14221
OMIM46 605552
NCIt39 C84442
MeSH34 D024821
ICD9CM27 277.7

Related Diseases for Metabolic Syndrome X

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17GeneCards, 18GeneDecks
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Diseases in the Metabolic Syndrome X family:

Acquired Metabolic Disease

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1277)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease30.8ADIPOQ, SERPINE1, IL6, INSR, INS, IGFBP1
2fatty liver disease30.7ADIPOQ, SERPINE1, LEP, INSR, INS, LPL
3hyperuricemia30.7INS
4polycystic ovary syndrome30.7LEP, INSR, INS, IGFBP1
5hepatitis30.6IGFBP1
6lipodystrophy30.6ADIPOQ, LEP, INSR, INS, LPL, PPARG
7hypogonadism30.5ADIPOQ, LEP, INS, LSL
8glucose intolerance30.5ADIPOQ, SERPINE1, SLC2A4, LEP, INSR, INS
9schizophrenia30.5INSR, INS, NR3C1
10psoriasis30.5IL6, TNF
11obesity30.5ADIPOQ, SERPINE1, SLC2A4, PLIN1, LEP, IL6
12hypertension30.4ALB, SERPINE1, LEP, INSR, INS, NR3C1
13gestational diabetes30.4ADIPOQ, SLC2A4, LEP, INSR, INS, IGFBP1
14essential hypertension30.4ADIPOQ, ALB, SERPINE1, LEP, INSR, INS
15ischemic heart disease30.4SERPINE1, CRP, LPL, LSL
16type 1 diabetes30.4ALB, LEP, INSR, INS, IGFBP1, LSL
17arthritis30.3ADIPOQ, ALB, LEP, IL6, CRP, TNF
18familial hyperlipidemia30.3INS, LPL
19morbid obesity30.3ADIPOQ, LEP, INS, LPL, LSL
20galactosemia30.3ADIPOQ, ALB, LEP, INS, NR3C1, PPARG
21familial combined hyperlipidemia30.3ADIPOQ, INS, LPL, LSL
22hepatitis c30.2ALB, LPL
23peripheral vascular disease30.2ALB, INS
24hyperhomocysteinemia30.2ALB, SERPINE1, CRP
25stroke, ischemic30.2ALB, SERPINE1, INS, CRP
26periodontal disease30.2IL6, CRP, TNF
27cerebrovascular disease30.2LPL
28coronary stenosis30.2ADIPOQ
29systemic lupus erythematosus30.2CRP
30arteriosclerosis30.2ADIPOQ, SERPINE1, LPL, PPARG
31bipolar disorder30.2NR3C1
32psoriatic arthritis30.2CRP, TNF
33multiple myeloma30.1IL6
34breast cancer30.1ALB, SERPINE1, SLC2A4, LEP, INSR, INS
35thyrotoxicosis30.1INS
36prediabetes syndrome30.1ADIPOQ, INS, PPARG
37neuropathy30.1ALB, INS
38hepatitis b30.1ADIPOQ, ALB
39atherosclerosis30.1ADIPOQ, ALB, SERPINE1, PLIN1, LEP, IL6
40hyperandrogenism30.1ADIPOQ, LEP, INSR, INS, IGFBP1, NR3C1
41rheumatoid arthritis30.1ADIPOQ, IL6, INSR, NR3C1, CRP, LPL
42diabetes mellitus30.1ADIPOQ, ALB, SERPINE1, SLC2A4, PLIN1, LEP
43cystic fibrosis30.1ALB, INS, LPL
44eating disorder30.0LEP, INS
45ischemia30.0SLC2A4, INSR
46acanthosis nigricans30.0ADIPOQ, LEP, INSR, INS
47diabetic nephropathy30.0ADIPOQ, ALB, SERPINE1, INS, PPARG
48prostate cancer30.0IL6, INSR, IGFBP1, NR3C1, LPL, PPARG
49pancreatitis30.0ALB, IL6, INS, CRP, LPL
50hyperparathyroidism29.9ALB

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Clinical Features for Metabolic Syndrome X

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46OMIM
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Clinical features from OMIM:

605552

Drugs & Therapeutics for Metabolic Syndrome X

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Metabolic Syndrome X

Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Search CenterWatch for Metabolic Syndrome X

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Metabolic Syndrome X

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22GTR
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Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X22

Anatomical Context for Metabolic Syndrome X

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32MalaCards
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MalaCards organs/tissues related to Metabolic Syndrome X:

32
Heart, Kidney, Liver, Brain, Ovary, Pituitary

Animal Models for Metabolic Syndrome X or affiliated genes

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36MGI
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Publications for Metabolic Syndrome X

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50PubMed
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Articles related to Metabolic Syndrome X:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. (23923606)
2013
2
Aberrant basal ganglia metabolism in fragile X syndrome: a magnetic resonance spectroscopy study. (23981510)
2013
3
Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. (19374165)
2009
4
Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome. (18452182)
2008
5
Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations. (18209740)
2008
6
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
7
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? (17475465)
2007
8
Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. (16999025)
2006
9
Aberrant expression of perilipins and 11-beta-HSD-1 as molecular signatures of metabolic syndrome X in south east Asians. (16941796)
2006
10
Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: a 2 x 2 factorial, randomized, double-blinded, placebo-controlled trial. (15714423)
2005
11
Potential regulatory role of the farnesoid X receptor in the metabolic syndrome. (15733743)
2005
12
Pathophysiology of metabolic syndrome X and its links to the perinatal period. (15925303)
2005
13
Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X. (15833894)
2005
14
HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure. (15470277)
2004
15
Metabolic syndrome X: an inflammatory condition? (14972097)
2004
16
Low-flow vascular remodeling in the metabolic syndrome X. (14644764)
2004
17
Swiss Medical Weekly Young Investigator's Award 2003: Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (15243846)
2004
18
Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. (14574352)
2003
19
Metabolic syndrome X is common in Indians: but, why and how? (14719590)
2003
20
The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. (12946657)
2003
21
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. (12756274)
2003
22
Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. (12781862)
2003
23
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. (12537988)
2003
24
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (12947532)
2003
25
Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome. (11887031)
2002
26
Metabolic syndrome X--high risk factor for acute myocardial infarction and its complications. (12137304)
2002
27
Molecular mechanism of vascular disease in metabolic syndrome X. (11872360)
2002
28
The metabolic syndrome X and peripheral cortisol synthesis. (12397528)
2002
29
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. (12512799)
2002
30
Obesity, metabolic syndrome X, and inflammation. (11985951)
2002
31
Is metabolic syndrome X an inflammatory condition? (12486208)
2002
32
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. (12018775)
2001
33
Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. (15573024)
2001
34
Steroid metabolism in metabolic syndrome X. (11469814)
2001
35
Metabolic syndrome X and fibrinolytic disturbances. (10870268)
2000
36
Metabolic syndrome X: a review. (10863169)
2000
37
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. (10842660)
1999
38
Enhanced activity of sodium-lithium countertransport in patients with cardiac syndrome X: a potential link between cardiac and metabolic syndrome X. (9857889)
1998
39
Thiazolidinediones--tools for the research of metabolic syndrome X. (9803467)
1998
40
Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. (9539185)
1998
41
The value of certain parameters in the diagnosis and detection of metabolic X syndrome]. (9380379)
1997
42
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. (9389420)
1997
43
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. (9075604)
1996
44
Androgen excess in women and the metabolic syndrome (syndrome X)]. (8759404)
1996
45
Serum angiotensin-I-converting enzyme activity in women with cardiological syndrome X: relation to blood pressure and lipid and carbohydrate metabolic risk markers for coronary heart disease. (7852538)
1995
46
The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. (1283771)
1992
47
Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete. (1644073)
1992
48
Clinical manifestations of insulin resistance. The hormonal-metabolic syndrome X (5H), its prevalence and impact on cardiovascular morbidity and mortality. I]. (1509712)
1992
49
How should we implement the basic principles of treatment of type 2 diabetes mellitus from the aspect of the hormono-metabolic syndrome X (5H)?]. (1455753)
1992
50
The metabolic X syndrome--4 case reports]. (1365060)
1992

Genetic Variations for Metabolic Syndrome X

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Expression for genes affiliated with Metabolic Syndrome X

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Metabolic Syndrome X

Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 49PharmGKB, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.1NR3C1
29.8SERPINE1, LEP, IGFBP1
39.7SLC2A4, INSR, INS
4
Hide members
9.7PLIN1, LEP, INS
5
Hide members
9.7INS, LPL, PPARG
69.7INS, INSR, LEP
7
Hide members
9.6NR3C1, INSR, SLC2A4
8
Translation Insulin regulation of translation
Hide members
9.5INS, INSR, SLC2A4, SERPINE1
99.5INS, INSR, LEP, SLC2A4
10
Hide members
9.5ALB, PLIN1, LPL
119.5INSR, LEP, SLC2A4, ADIPOQ
129.4ADIPOQ, PLIN1, LPL, PPARG
139.3SERPINE1, IL6, INSR, INS
149.3TNF, LEP, SLC2A4, ADIPOQ
159.2TNF, NR3C1, IL6
169.2ALB, INS, IGFBP1, NR3C1
179.1CRP, IGFBP1, INS, ALB
188.9PPARG, LPL, LEP, PLIN1, SLC2A4, ADIPOQ
19
Hide members
8.9TNF, INS, INSR, SLC2A4, ADIPOQ
208.9PPARG, INS, INSR, PLIN1, SLC2A4, ADIPOQ
218.7NR3C1, IGFBP1, INS, INSR, IL6, LEP
228.5ADIPOQ, PPARG, LPL, INS, LEP, PLIN1
23
Hide members
8.3TNF, INS, INSR, IL6, LEP, SLC2A4
24
Hide members
8.0TNF, PPARG, LPL, INS, INSR, IL6
257.9TNF, CRP, INS, INSR, IL6, SERPINE1

Compounds for genes affiliated with Metabolic Syndrome X

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6IGFBP1
2estrogen4410.6HSD11B1
3uric acid44 2411.5SERPINE1
4norepinephrine44 11 2412.1LPL, PLIN1, SLC2A4
5palmitate449.9ADIPOQ, SLC2A4, INS
6indomethacin44 59 28 1112.5LEP, PPARG, SLC2A4, IGFBP1
7losartan44 49 28 1112.5CRP, SLC2A4, SERPINE1, ALB
8glimepiride44 49 1111.3ADIPOQ, SLC2A4, INSR, INS, PPARG, SERPINE1
9aicar44 11 2411.2ADIPOQ, SLC2A4, LEP, INSR, INS, PPARG
10glycerol 3-phosphate44 2410.1HSD11B1, LPL, LEP, PLIN1, SLC2A4, ADIPOQ
11vitamin d449.1IL6, INSR, IGFBP1, LPL, ADIPOQ, PPARG
12gliclazide44 49 1111.1ALB, SLC2A4, INSR, ADIPOQ, INS
13bezafibrate44 28 1111.0LPL, ADIPOQ, SERPINE1, INS, CRP, PPARG
14prednisolone44 28 1111.0CRP, LSL, HSD11B1, NR3C1, IGFBP1
15ramipril44 1110.0SERPINE1, INS, CRP, ADIPOQ, ALB
16telmisartan44 28 1111.0CRP, PPARG, ADIPOQ, INS, LEP, ALB
17orlistat44 59 1110.9PPARG, LSL, LPL, INS, LEP, ADIPOQ
18glucose448.9PPARG, INSR, PLIN1, SLC2A4, LSL, LPL
19thiazolidinedione448.8PPARG, LPL, CRP, INS, LEP, SLC2A4
20dhea448.7LEP, HSD11B1, LSL, ADIPOQ, NR3C1, INS
21dexamethasone44 49 28 1111.7NR3C1, INS, INSR, HSD11B1, LPL, ADIPOQ
22hydrocortisone44 2 59 1111.7LSL, NR3C1, IGFBP1, INS, INSR, ADIPOQ
23triacylglycerol448.7LEP, LPL, INS, ADIPOQ, SERPINE1, PLIN1
248-isoprostane448.6SERPINE1, ADIPOQ, LEP, INS, CRP, TNF
25valsartan44 59 28 1111.5CRP, ADIPOQ, PPARG, ALB, SERPINE1
26troglitazone44 28 59 1111.5LSL, PPARG, LPL, INS, INSR, SLC2A4
27rosiglitazone44 49 28 11 2412.5HSD11B1, LSL, IGFBP1, INS, INSR, IL6
28nash448.5INS, LEP, TNF, ADIPOQ, LSL
29olanzapine49 44 28 11 2412.5ALB, ADIPOQ, SLC2A4, LEP, LSL, INS
30pravastatin44 49 28 11 2412.4CRP, PPARG, IL6, SERPINE1, ADIPOQ, LSL
31c-peptide448.4INSR, SERPINE1, LSL, CRP, IGFBP1, ADIPOQ
32atorvastatin44 49 28 11 2412.3TNF, PPARG, LPL, CRP, IL6, SERPINE1
33rapamycin448.2ADIPOQ, INS, INSR, PPARG, CRP, NR3C1
34fatty acid448.0HSD11B1, LSL, FADS1, PPARG, LPL, IGFBP1
35thyroxine44 249.0ALB, ADIPOQ, PPARG, INSR, LSL, LPL
36creatinine447.9LEP, INSR, INS, IGFBP1, CRP, LSL
37sb 20358044 598.9IL6, SLC2A4, NR3C1, CRP, PPARG, TNF
38fenofibrate44 49 119.8TNF, PPARG, LPL, CRP, INS, INSR
39glycerol44 11 249.8INSR, LEP, PLIN1, SLC2A4, ADIPOQ, INS
40simvastatin44 49 59 28 11 2412.7TNF, PPARG, FADS1, ADIPOQ, SERPINE1, IL6
41metformin44 49 119.7SLC2A4, SERPINE1, ADIPOQ, LEP, INSR, INS
42methotrexate44 49 119.6IL6, TNF, LSL, ADIPOQ, ALB, SERPINE1
43ly294002447.5LEP, SERPINE1, TNF, PPARG, CRP, ADIPOQ
44fibrinogen447.3LEP, SERPINE1, ALB, ADIPOQ, IGFBP1, IL6
45alanine447.3PPARG, ADIPOQ, CRP, SLC2A4, IL6, INSR
46pioglitazone44 49 28 1110.2SLC2A4, SERPINE1, ADIPOQ, LEP, IL6, INSR
47lactate447.0LSL, CRP, ADIPOQ, ALB, IL6, SLC2A4
48testosterone44 59 11 249.3HSD11B1, NR3C1, LSL, PPARG, ADIPOQ, ALB
49cholesterol44 28 11 249.0LEP, PLIN1, SERPINE1, ALB, ADIPOQ, HSD11B1
50lipid445.0INSR, IL6, LEP, PLIN1, SLC2A4, SERPINE1

GO Terms for genes affiliated with Metabolic Syndrome X

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16Gene Ontology
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Cellular components related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3LPL, CRP, IGFBP1, INS, IL6, LEP
2extracellular spaceGO:0056157.0ADIPOQ, TNF, LPL, CRP, IGFBP1, INS

Biological processes related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:04662810.3INS, LEP
2positive regulation of developmental growthGO:04863910.3INSR, LEP
3positive regulation of respiratory burstGO:06026710.3INS, INSR
4negative regulation of acute inflammatory responseGO:00267410.3PPARG, INS
5negative regulation of smooth muscle cell migrationGO:01491210.3ADIPOQ, SERPINE1
6positive regulation of STAT protein import into nucleusGO:200036610.3IL6, LEP
7regulation of gluconeogenesisGO:00611110.2LEP, NR3C1
8brown fat cell differentiationGO:05087310.1PPARG, SLC2A4, ADIPOQ
9positive regulation of glycolysisGO:04582110.1INS, INSR
10positive regulation of glucose importGO:04632610.0ADIPOQ, INSR, INS
11negative regulation of gluconeogenesisGO:04572110.0INS, IL6, ADIPOQ
12negative regulation of hormone secretionGO:04688810.0IL6, ADIPOQ
13response to caffeineGO:0310009.9PPARG, IL6
14negative regulation of macrophage derived foam cell differentiationGO:0107459.9PPARG, CRP, ADIPOQ
15epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9TNF, IL6
16positive regulation of DNA replicationGO:0457409.9INS, INSR, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9INS, IL6, ADIPOQ
18positive regulation of protein phosphorylationGO:0019349.9ADIPOQ, INSR
19cellular response to insulin stimulusGO:0328699.8PPARG, INSR, SLC2A4, ADIPOQ
20acute-phase responseGO:0069539.8CRP, INS, IL6
21response to ethanolGO:0454719.8CRP, SLC2A4, ADIPOQ
22positive regulation of mitosisGO:0458409.8INSR, INS, TNF
23leukocyte tethering or rollingGO:0509019.8TNF, LEP
24response to nutrientGO:0075849.8PPARG, ALB, ADIPOQ
25response to sucrose stimulusGO:0097449.7FADS1, ADIPOQ
26positive regulation of MAPK cascadeGO:0434109.7LEP, IL6, INSR, INS
27regulation of insulin secretionGO:0507969.7TNF, INS, LEP
28negative regulation of fat cell differentiationGO:0455999.7ADIPOQ, IL6, TNF
29positive regulation of cellular protein metabolic processGO:0322709.7ADIPOQ, INS
30response to glucocorticoid stimulusGO:0513849.6ADIPOQ, IL6, TNF
31glucose metabolic processGO:0060069.6TNF, INS, LEP, ADIPOQ
32negative regulation of lipid storageGO:0108889.6IL6, CRP, TNF
33glucose homeostasisGO:0425939.6ADIPOQ, SLC2A4, INSR, INS, PPARG
34defense response to Gram-positive bacteriumGO:0508309.6TNF, CRP, IL6
35positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6TNF, PPARG, IL6
36positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, INS, INSR, IL6
37positive regulation of protein kinase B signaling cascadeGO:0518979.4IL6, INSR, INS, TNF
38response to hypoxiaGO:0016669.4TNF, CRP, LEP, ADIPOQ
39response to insulin stimulusGO:0328689.4LEP, IL6, FADS1
40response to vitamin AGO:0331899.4PPARG, FADS1
41response to drugGO:0424938.9TNF, PPARG, LPL, IL6
42small molecule metabolic processGO:0442818.2HSD11B1, FADS1, LPL, INS, PLIN1, SLC2A4

Molecular functions related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7ADIPOQ, LEP, INS
2protease bindingGO:0020209.2SERPINE1, INS, TNF

Products for genes affiliated with Metabolic Syndrome X

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Sources for Metabolic Syndrome X

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet