AOMS1
MCID: MTB001
MIFTS: 56

Metabolic Syndrome X (AOMS1) malady

Metabolic category

Summaries for Metabolic Syndrome X

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. these conditions are high blood pressure high blood glucose, or blood sugar, levels high levels of triglycerides, a type of fat, in your blood low levels of hdl, the good cholesterol, in your blood too much fat around your waist not all doctors agree on the definition or cause of metabolic syndrome. the cause might be insulin resistance. insulin is a hormone your body produces to help you turn sugar from food into energy for your body. if you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Metabolic Syndrome X, also known as abdominal obesity-metabolic syndrome, is related to coronary artery disease, and fatty liver disease. An important gene associated with Metabolic Syndrome X is AOMS1 (Abdominal obesity-metabolic syndrome QTL1), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and HIF-1-alpha transcription factor network. The drugs magnesium hydroxide and milk of magnesia and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney and heart, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:64 Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of 3... more...

Description from OMIM:47 605552

Aliases & Classifications for Metabolic Syndrome X

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 47OMIM, 64Wikipedia, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

metabolic syndrome x 8 43 22 10 45 61
abdominal obesity-metabolic syndrome 8 47
abdominal obesity metabolic syndrome 43 61
metabolic disorders 64 34
metabolic syndrome 8 34
dysmetabolic syndrome x 8
metabolic diseases 61
metabolic disorder 45
aoms1 43


External Ids:

Disease Ontology8 DOID:14221
OMIM47 605552
NCIt40 C84442
MeSH35 D024821
ICD9CM27 277.7

Related Diseases for Metabolic Syndrome X

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Metabolic Syndrome X family:

acquired metabolic disease acquired metabolic neuropathy

Diseases related to Metabolic Syndrome X via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 615)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease,30.8ADIPOQ, SERPINE1, IL6, INSR, INS, IGFBP1
2fatty liver disease30.8ADIPOQ, SERPINE1, LEP, INSR, INS, LPL
3hyperuricemia30.8INS
4polycystic ovary syndrome30.7LEP, INSR, INS, IGFBP1
5glucose intolerance30.6ADIPOQ, SERPINE1, SLC2A4, LEP, INSR, INS
6insulin resistance30.5ADIPOQ, ALB, SERPINE1, SLC2A4, PLIN1, LEP
7hypertriglyceridemia30.5ADIPOQ, SERPINE1, SLC2A4, LEP, INSR, INS
8gestational diabetes30.4ADIPOQ, SLC2A4, LEP, INSR, INS, IGFBP1
9arthritis30.4ADIPOQ, ALB, LEP, IL6, CRP, TNF
10hepatitis c30.4ALB, LPL
11morbid obesity30.4ADIPOQ, LEP, INS, LPL, LSL
12familial combined hyperlipidemia30.3ADIPOQ, INS, LPL, LSL
13peripheral vascular disease30.3ALB, INS
14hyperhomocysteinemia30.3ALB, SERPINE1, CRP
15stroke, ischemic30.3ALB, SERPINE1, INS, CRP
16hypercholesterolemia30.3ADIPOQ, SERPINE1, INSR, INS, CRP, LPL
17systemic lupus erythematosus30.2CRP
18arteriosclerosis30.2ADIPOQ, SERPINE1, LPL, PPARG
19bipolar disorder30.2NR3C1
20psoriatic arthritis30.2CRP, TNF
21hyperandrogenism30.1ADIPOQ, LEP, INSR, INS, IGFBP1, NR3C1
22atherosclerosis30.1ADIPOQ, ALB, SERPINE1, PLIN1, LEP, IL6
23prediabetes syndrome30.1ADIPOQ, INS, PPARG
24acanthosis nigricans30.1ADIPOQ, LEP, INSR, INS
25growth hormone deficiency30.0ADIPOQ, LEP, INS, IGFBP1, LSL
26alzheimer's disease30.0IL6, INSR, INS, PPARG
27diabetic nephropathy30.0ADIPOQ, ALB, SERPINE1, INS, PPARG
28osteoarthritis30.0IL6, NR3C1, CRP, TNF, HSD11B1
29acute myocardial infarction30.0SERPINE1, IGFBP1, CRP
30cushing's syndrome29.9ADIPOQ, LEP, IGFBP1, NR3C1, LPL, LSL
31vascular disease29.9ADIPOQ, SERPINE1, INS, CRP, LPL, PPARG
32coronary heart disease29.9ADIPOQ, SERPINE1, LEP, IL6, INS, NR3C1
33amyloidosis29.9ALB, CRP, LPL
34thromboembolism29.9SERPINE1
35aortic aneurysm29.9CRP
36infertility29.9LEP, INS, IGFBP1, LSL
37colorectal cancer29.9INSR, LPL, PPARG
38prader-willi syndrome29.9ADIPOQ, LEP, INS, LSL
39adenoma29.9INSR, INS, IGFBP1, PPARG, HSD11B1
40asthma29.9ADIPOQ, NR3C1, TNF
41adenocarcinoma29.9SLC2A4, INSR, IGFBP1, NR3C1, HSD11B1
42osteoporosis29.9LEP, IL6, NR3C1, LSL, HSD11B1
43type 1 diabetes29.9ALB, LEP, INSR, INS, IGFBP1, LSL
44werner syndrome29.7INSR
45hypercalcemia29.7ALB
46insulinoma29.7INSR, INS
47anorexia nervosa29.7ADIPOQ, LEP, IGFBP1, LSL
48metabolic acidosis29.7ALB
49acromegaly29.7ADIPOQ, LEP, INS, IGFBP1, LSL, HSD11B1
50septic shock29.7SERPINE1, IL6, CRP, TNF

Graphical network of the top 20 diseases related to Metabolic Syndrome X:



Diseases related to metabolic syndrome x

Clinical Features for Metabolic Syndrome X

Sources:
47OMIM
See all sources

Clinical features from OMIM:

605552

Drugs & Therapeutics for Metabolic Syndrome X

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Metabolic Syndrome X

Drug clinical trials:

Search ClinicalTrials for Metabolic Syndrome X

Search NIH Clinical Center for Metabolic Syndrome X

Search CenterWatch for Metabolic Syndrome X

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Metabolic Syndrome X

Sources:
22GTR
See all sources

Genetic tests related to Metabolic Syndrome X:

id Genetic test Affiliating Genes
1 Metabolic Syndrome X22

Anatomical Context for Metabolic Syndrome X

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Metabolic Syndrome X:

33
Kidney, Heart

Animal Models for Metabolic Syndrome X or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Metabolic Syndrome X

Sources:
51PubMed
See all sources

Articles related to Metabolic Syndrome X:

idTitleAuthorsYear
1
Association of genetic variations of PRDM16 with metabolic syndrome in a general Xinjiang Uygur population. (22383139)
2012
2
Association of lipoprotein lipase gene Hind III and S447X polymorphisms in metabolic syndrome patients among Kazakh and Han ethnics from Xinjiang]. (21162862)
2010

Genetic Variations for Metabolic Syndrome X

Expression for genes affiliated with Metabolic Syndrome X

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Metabolic Syndrome X

Search GEO for disease gene expression data for Metabolic Syndrome X.

Pathways for genes affiliated with Metabolic Syndrome X

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG, 50PharmGKB, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.1NR3C1
29.8IGFBP1, SERPINE1, LEP
39.7INSR, SLC2A4, INS
4
Hide members
9.7PLIN1, LEP, INS
5
Hide members
9.7INS, PPARG, LPL
69.7INS, INSR, LEP
7
Hide members
9.6INSR, SLC2A4, NR3C1
8
Translation Insulin regulation of translation
Hide members
9.5SLC2A4, INS, INSR, SERPINE1
99.5INS, INSR, LEP, SLC2A4
10
Hide members
9.5ALB, PLIN1, LPL
119.5INSR, LEP, ADIPOQ, SLC2A4
129.4ADIPOQ, PLIN1, LPL, PPARG
139.3IL6, SERPINE1, INSR, INS
149.3ADIPOQ, TNF, SLC2A4, LEP
159.2NR3C1, TNF, IL6
169.2INS, ALB, IGFBP1, NR3C1
179.1ALB, CRP, INS, IGFBP1
188.9SLC2A4, ADIPOQ, LEP, LPL, PLIN1, PPARG
19
Hide members
8.9INSR, INS, TNF, ADIPOQ, SLC2A4
208.9SLC2A4, ADIPOQ, PPARG, INS, INSR, PLIN1
218.7INSR, INS, IL6, IGFBP1, NR3C1, LEP
228.5SLC2A4, PPARG, LPL, LEP, PLIN1, SERPINE1
23
Hide members
8.3LEP, TNF, ADIPOQ, SLC2A4, IL6, INSR
24
Hide members
8.0ADIPOQ, LEP, INS, LPL, PPARG, TNF
257.9IL6, INSR, INS, ALB, CRP, TNF

Compounds for genes affiliated with Metabolic Syndrome X

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6IGFBP1
2estrogen4510.6HSD11B1
3uric acid45 2411.5SERPINE1
4norepinephrine45 11 2412.1LPL, PLIN1, SLC2A4
5palmitate459.9ADIPOQ, SLC2A4, INS
6indomethacin45 60 29 1112.5LEP, PPARG, SLC2A4, IGFBP1
7losartan45 50 29 1112.5CRP, SLC2A4, SERPINE1, ALB
8glimepiride45 50 1111.3ADIPOQ, SLC2A4, INSR, INS, PPARG, SERPINE1
9aicar45 11 2411.2ADIPOQ, SLC2A4, LEP, INSR, INS, PPARG
10glycerol 3-phosphate45 2410.1HSD11B1, LPL, LEP, PLIN1, SLC2A4, ADIPOQ
11vitamin d459.1IL6, INSR, IGFBP1, LPL, ADIPOQ, PPARG
12gliclazide45 50 1111.1ALB, SLC2A4, INSR, ADIPOQ, INS
13bezafibrate45 29 1111.0LPL, ADIPOQ, SERPINE1, INS, CRP, PPARG
14prednisolone45 29 1111.0CRP, LSL, HSD11B1, NR3C1, IGFBP1
15ramipril45 1110.0SERPINE1, INS, CRP, ADIPOQ, ALB
16telmisartan45 29 1111.0CRP, PPARG, ADIPOQ, INS, LEP, ALB
17orlistat45 60 1110.9PPARG, LSL, LPL, INS, LEP, ADIPOQ
18glucose458.9PPARG, INSR, PLIN1, SLC2A4, LSL, LPL
19thiazolidinedione458.8PPARG, LPL, CRP, INS, LEP, SLC2A4
20dhea458.7LEP, HSD11B1, LSL, ADIPOQ, NR3C1, INS
21dexamethasone45 50 29 1111.7NR3C1, INS, INSR, HSD11B1, LPL, ADIPOQ
22hydrocortisone45 2 60 1111.7LSL, NR3C1, IGFBP1, INS, INSR, ADIPOQ
23triacylglycerol458.7LEP, LPL, INS, ADIPOQ, SERPINE1, PLIN1
248-isoprostane458.6SERPINE1, ADIPOQ, LEP, INS, CRP, TNF
25valsartan45 60 29 1111.5CRP, ADIPOQ, PPARG, ALB, SERPINE1
26troglitazone45 29 60 1111.5LSL, PPARG, LPL, INS, INSR, SLC2A4
27rosiglitazone45 50 29 11 2412.5HSD11B1, LSL, IGFBP1, INS, INSR, IL6
28nash458.5INS, LEP, TNF, ADIPOQ, LSL
29olanzapine50 45 29 11 2412.5ALB, ADIPOQ, SLC2A4, LEP, LSL, INS
30pravastatin45 50 29 11 2412.4CRP, PPARG, IL6, SERPINE1, ADIPOQ, LSL
31c-peptide458.4INSR, SERPINE1, LSL, CRP, IGFBP1, ADIPOQ
32atorvastatin45 50 29 11 2412.3TNF, PPARG, LPL, CRP, IL6, SERPINE1
33rapamycin458.2ADIPOQ, INS, INSR, PPARG, CRP, NR3C1
34fatty acid458.0HSD11B1, LSL, FADS1, PPARG, LPL, IGFBP1
35thyroxine45 249.0ALB, ADIPOQ, PPARG, INSR, LSL, LPL
36creatinine457.9LEP, INSR, INS, IGFBP1, CRP, LSL
37sb 20358045 608.9IL6, SLC2A4, NR3C1, CRP, PPARG, TNF
38fenofibrate45 50 119.8TNF, PPARG, LPL, CRP, INS, INSR
39glycerol45 11 249.8INSR, LEP, PLIN1, SLC2A4, ADIPOQ, INS
40simvastatin45 50 60 29 11 2412.7TNF, PPARG, FADS1, ADIPOQ, SERPINE1, IL6
41metformin45 50 119.7SLC2A4, SERPINE1, ADIPOQ, LEP, INSR, INS
42methotrexate45 50 119.6IL6, TNF, LSL, ADIPOQ, ALB, SERPINE1
43ly294002457.5LEP, SERPINE1, TNF, PPARG, CRP, ADIPOQ
44fibrinogen457.3LEP, SERPINE1, ALB, ADIPOQ, IGFBP1, IL6
45alanine457.3PPARG, ADIPOQ, CRP, SLC2A4, IL6, INSR
46pioglitazone45 50 29 1110.2SLC2A4, SERPINE1, ADIPOQ, LEP, IL6, INSR
47lactate457.0LSL, CRP, ADIPOQ, ALB, IL6, SLC2A4
48testosterone45 60 11 249.3HSD11B1, NR3C1, LSL, PPARG, ADIPOQ, ALB
49cholesterol45 29 11 249.0LEP, PLIN1, SERPINE1, ALB, ADIPOQ, HSD11B1
50lipid455.0INSR, IL6, LEP, PLIN1, SLC2A4, SERPINE1

GO Terms for genes affiliated with Metabolic Syndrome X

Sources:
16Gene Ontology
See all sources

Cellular components related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3TNF, ALB, SERPINE1, LEP, IL6, INS
2extracellular spaceGO:0056157.0TNF, ALB, SERPINE1, LEP, IL6, INS

Biological processes related to Metabolic Syndrome X according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:04662810.3LEP, INS
2positive regulation of developmental growthGO:04863910.3LEP, INSR
3positive regulation of respiratory burstGO:06026710.3INSR, INS
4negative regulation of acute inflammatory responseGO:00267410.3PPARG, INS
5negative regulation of smooth muscle cell migrationGO:01491210.3SERPINE1, ADIPOQ
6positive regulation of STAT protein import into nucleusGO:200036610.2LEP, IL6
7regulation of gluconeogenesisGO:00611110.2NR3C1, LEP
8brown fat cell differentiationGO:05087310.1PPARG, SLC2A4, ADIPOQ
9positive regulation of glycolysisGO:04582110.1INSR, INS
10positive regulation of glucose importGO:04632610.0INSR, ADIPOQ, INS
11negative regulation of gluconeogenesisGO:04572110.0IL6, ADIPOQ, INS
12negative regulation of hormone secretionGO:04688810.0IL6, ADIPOQ
13positive regulation of cellular protein metabolic processGO:03227010.0ADIPOQ, INS
14response to caffeineGO:0310009.9PPARG, IL6
15negative regulation of macrophage derived foam cell differentiationGO:0107459.9CRP, PPARG, ADIPOQ
16epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9IL6, TNF
17positive regulation of DNA replicationGO:0457409.9INS, INSR, IL6
18positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9ADIPOQ, IL6, INS
19positive regulation of protein phosphorylationGO:0019349.9INSR, ADIPOQ
20cellular response to insulin stimulusGO:0328699.8SLC2A4, INSR, PPARG, ADIPOQ
21response to ethanolGO:0454719.8SLC2A4, ADIPOQ, CRP
22acute-phase responseGO:0069539.8INS, IL6, CRP
23positive regulation of mitosisGO:0458409.8INSR, INS, TNF
24leukocyte tethering or rollingGO:0509019.8TNF, LEP
25response to nutrientGO:0075849.8PPARG, ALB, ADIPOQ
26response to sucrose stimulusGO:0097449.7FADS1, ADIPOQ
27positive regulation of MAPK cascadeGO:0434109.7INS, INSR, LEP, IL6
28negative regulation of fat cell differentiationGO:0455999.7TNF, IL6, ADIPOQ
29regulation of insulin secretionGO:0507969.7TNF, INS, LEP
30response to glucocorticoid stimulusGO:0513849.6ADIPOQ, IL6, TNF
31glucose metabolic processGO:0060069.6TNF, INS, LEP, ADIPOQ
32negative regulation of lipid storageGO:0108889.6IL6, CRP, TNF
33glucose homeostasisGO:0425939.6ADIPOQ, SLC2A4, INSR, INS, PPARG
34defense response to Gram-positive bacteriumGO:0508309.6CRP, TNF, IL6
35positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6PPARG, TNF, IL6
36positive regulation of nitric oxide biosynthetic processGO:0454299.4INSR, IL6, INS, TNF
37positive regulation of protein kinase B signaling cascadeGO:0518979.4INSR, INS, TNF, IL6
38response to hypoxiaGO:0016669.4ADIPOQ, LEP, CRP, TNF
39response to insulin stimulusGO:0328689.4LEP, IL6, FADS1
40response to vitamin AGO:0331899.1FADS1, PPARG
41response to drugGO:0424938.9TNF, PPARG, LPL, IL6
42small molecule metabolic processGO:0442818.2FADS1, ALB, SLC2A4, PLIN1, INS, LPL

Molecular functions related to Metabolic Syndrome X according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7ADIPOQ, LEP, INS
2protease bindingGO:0020209.2SERPINE1, INS, TNF

Products for genes affiliated with Metabolic Syndrome X

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Metabolic Syndrome X

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet