MCID: MTH007
MIFTS: 55

Methemoglobinemia malady

Immune diseases, Blood diseases categories

Summaries for Methemoglobinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Methemoglobinemia (or methaemoglobinaemia) is a disorder characterized by the presence of a higher than... more...

MalaCards: Methemoglobinemia, also known as methemoglobinemia nos, is related to hemolytic anemia and sulfhemoglobinemia. An important gene associated with Methemoglobinemia is CYB5R3 (cytochrome b5 reductase 3), and among its related pathways are Vitamin C (ascorbate) metabolism and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs ascorbic acid and methylene blue and the compounds alpha tocopherol and hads have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung.

Aliases & Classifications for Methemoglobinemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

methemoglobinemia 8 10 44 60
methemoglobinemia nos 8
methaemoglobinaemia 8


External Ids:

Disease Ontology8 DOID:10783
ICD9CM27 289.7
MeSH34 D008708
NCIt39 C34817
ICD1025 D74, D74.9

Related Diseases for Methemoglobinemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Methemoglobinemia, Type I family:

Congenital Methemoglobinemia methemoglobinemia
Methemoglobinemias, Beta- Methemoglobinemias, Alpha-
Methemoglobinemia, Type Iv Methemoglobinemia, Type Ii

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.5G6PD, HBB, HBG2, HP
2sulfhemoglobinemia30.4SHB, HBG2
3methemoglobinemia, type iv30.2HBG2, CYB5R3, CYB5A
4pneumonia30.1MT-CYB
5malaria30.1G6PD, MT-CYB, HBB, HP, GSR
6favism29.8HP, G6PD
7hyperglycemia29.8SOD1, HBA1
8hemoglobinopathy29.8HP, HBB, G6PD
9tuberculosis29.8GSR, HP, HBB
10congenital methemoglobinemia10.8
11methemoglobinemia beta-globin type10.4
12methemoglobinemia, type i10.4
13diarrhea10.2
14leukemia10.2
15autosomal dominant methemoglobinemia10.2
16aspiration pneumonia10.1
17burns10.1
18hereditary methemoglobinemia, recessive10.1
19pharyngitis10.0
20cervicitis10.0
21leprosy10.0
22respiratory failure10.0
23thalassemia10.0
24vaginitis10.0
25nadh cytochrome b5 reductase deficiency10.0
26methemoglobinemias, beta-10.0
27methemoglobinemias, alpha-10.0
28methemoglobinemia, type ii10.0
29fetal hemoglobin quantitative trait locus 110.0HBG2
30viral hepatitis10.0G6PD
31ariboflavinosis10.0GSR
32blackwater fever10.0G6PD
33galactosemia10.0HP
34iron deficiency anemia10.0HBG2, G6PD
35friedreich ataxia10.0GSR
36nephrotic syndrome10.0HP
37diabetic cataract10.0G6PD, GSR
38wilson disease10.0G6PD, SOD1
39chronic granulomatous disease10.0MT-CYB
40leishmaniasis10.0MT-CYB
41obesity10.0MT-CYB
42leber hereditary optic neuropathy10.0MT-CYB
43gastric ulcer10.0GSR
44aspergillosis10.0MT-CYB
45septo-optic dysplasia10.0SOD1
46congenital hemolytic anemia10.0HP, G6PD
47bilirubin metabolic disorder10.0HP, HBG2, G6PD
48glucosephosphate dehydrogenase deficiency10.0G6PD, HP, GSR
49hydrops fetalis10.0HBB
50acute kidney failure10.0HP, HBG2, G6PD

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to methemoglobinemia

Clinical Features for Methemoglobinemia

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Drugs & Therapeutics for Methemoglobinemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Methemoglobinemia

Drug clinical trials:

Search ClinicalTrials for Methemoglobinemia

Search NIH Clinical Center for Methemoglobinemia

Search CenterWatch for Methemoglobinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Methemoglobinemia

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Anatomical Context for Methemoglobinemia

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32MalaCards
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MalaCards organs/tissues related to Methemoglobinemia:

32
Heart, Kidney, Lung, Spleen, Brain, Liver, Skin, Testes, Whole blood

Animal Models for Methemoglobinemia or affiliated genes

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Publications for Methemoglobinemia

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Sources:
50PubMed
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Articles related to Methemoglobinemia:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Methemoglobinemia from curing salt. (23670150)
2013
2
Response to Weingarten, "Methemoglobinemia in the setting of chronic transdermal lidocaine patch use," Pain Medicine 2012. (23578070)
2013
3
Topical anesthetic-induced methemoglobinemia and veterans affairs hospitals. (24276056)
2013
4
Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia. (22335579)
2012
5
Methemoglobinemia induced by rasburicase in a pediatric patient: a case report and literature review. (22190578)
2012
6
Nasal tetracaine spray-induced methemoglobinemia. (21900538)
2012
7
Methemoglobinemia and ascorbate deficiency in hemoglobin E I^ thalassemia: metabolic and clinical implications. (22885163)
2012
8
Novel large deletion c.22-1320_633+1224del in the CYB5R3 gene from patients with hereditary methemoglobinemia]. (23297489)
2012
9
Benzocaine-induced methemoglobinemia in an acute-exposure rat model. (21726594)
2011
10
Severe mental retardation and recessive congenital methemoglobinemia in three Indian patients: compound heterozygous for NADH-cytochrome b5 reductase gene mutations. (21328435)
2011
11
Successful treatment of methemoglobinemia and acute renal failure after indoxacarb poisoning. (21867363)
2011
12
Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase. (21244096)
2011
13
Acute methemoglobinemia associated with ochronotic valvular heart disease: report of a case. (20333576)
2010
14
Acquired methemoglobinemia revisited. (20831930)
2010
15
Lethal methemoglobinemia and automobile exhaust inhalation. (19261402)
2009
16
Acute cyanosis in a child after percutaneous placement of a peritoneal dialysis catheter: question. Methemoglobinemia. (19172299)
2009
17
Methemoglobinemia and adverse events in Plasmodium vivax malaria patients associated with high doses of primaquine treatment. (19190211)
2009
18
Dapsone induced methemoglobinemia in a patient with glioblastoma. (19219404)
2009
19
Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. (17387701)
2008
20
Methemoglobinemia due to malachite green ingestion in a child. (18363129)
2008
21
Poppers-induced methemoglobinemia: an unusual cause of cyanosis. (19078845)
2008
22
Methemoglobinemia and benzocaine. (18049203)
2007
23
Transient methemoglobinemia in an infant. (18057688)
2007
24
Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors. (17923598)
2007
25
Case of methemoglobinemia. (16583668)
2006
26
Methylene blue treatment for methemoglobinemia and subsequent dramatic bispectral index reduction. (16810025)
2006
27
Methemoglobinemia in critically ill burned patients. (15728951)
2005
28
Hemolysis and methemoglobinemia secondary to rasburicase administration. (16204390)
2005
29
A search for mutations in the DIA1 gene in case of hereditary methemoglobinemia type I in the iakut population]. (12884529)
2003
30
Cyclophosphamide-induced methemoglobinemia. (14625586)
2003
31
Congenital methemoglobinemia: a rare cause of cyanosis in the newborn--a case report. (12897322)
2003
32
Methemoglobinemia and topical pharyngeal anesthesia. (12510055)
2003
33
Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency in three Indian families. (12803131)
2002
34
Dapsone-induced methemoglobinemia in pediatric oncology patients: case examples. (11588763)
2001
35
Benzocaine-associated methemoglobinemia following bronchoscopy in a healthy research participant. (10963319)
2000
36
Public notification to families with newborns at risk of methemoglobinemia from drinking water exposure, Clymer, New York, 1996-1998. (10537817)
1999
37
Emergency! Methemoglobinemia. (10333801)
1999
38
When patients become cyanotic: acquired methemoglobinemia. (10377640)
1999
39
Neonatal methemoglobinemia due to transplacental transfer of dapsone. (10216653)
1998
40
Metobromuron/metolachlor ingestion with late onset methemoglobinemia in a pregnant woman successfully treated with methylene blue. (8523499)
1995
41
Dapsone-induced methemoglobinemia: an anesthetic risk. (7558644)
1995
42
Life-threatening methemoglobinemia in infants with diarrhea and acidosis. (8200173)
1994
43
Methemoglobinemia in a patient undergoing gastrointestinal endoscopy. (1421647)
1992
44
Dapsone-induced methemoglobinemia and pulse oximetry. (1519798)
1992
45
Toxic methemoglobinemia caused by topical anesthetic given before transesophageal echocardiography. (1760183)
1991
46
Flutamide-induced methemoglobinemia. (1877268)
1991
47
Propanil-induced methemoglobinemia and hemoglobin binding in the rat. (2237922)
1990
48
Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency: report of a case. (3241162)
1988
49
Leukocyte diaphorase deficiency in congenital methemoglobinemia: a valuable prognostic indicator. (603804)
1977
50
Sulfhemoglobinemia and methemoglobinemia--uncommon causes of cyanosis. (1190530)
1975

Genetic Variations for Methemoglobinemia

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Expression for genes affiliated with Methemoglobinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for genes affiliated with Methemoglobinemia

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53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Methemoglobinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Methemoglobinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.4G6PD, CYB5A
2hads4410.3CYB5R3, HBG2, CYB5A
3no-dimethylhydroxylamine4410.2G6PD, HBG2, GSR
4ferricyanide4410.2CYB5A, HBG2, CYB5R3
5primaquine49 44 1112.2CYB5R3, G6PD, HBG2
6methylene blue49 4411.2BLVRB, CYB5R3, G6PD
73-amino-1,2,4-triazole4410.1SOD1, GSR, HBG2
8s-nitrosocysteine4410.1SOD1, HBB, HBG2
9dehydroascorbic acid44 1111.1SOD1, G6PD, GSR
10semiquinone4410.0MT-CYB, SOD1, HBG2, CYB5R3
11thiobarbituric acid4410.0G6PD, HP, SOD1, GSR
12benzamidoxime4410.0CYB5A, CYB5R3
13glucose 6-phosphate44 2411.0CYB5R3, G6PD, SOD1, HBB
1423-diphosphoglycerate4410.0HP, HBG2, HBB, G6PD
15fenton4410.0HBG2, GSR, MT-CYB, SOD1
16gssg4410.0GSR, SOD1, G6PD, HBG2
17methylene4410.0HBG2, G6PD, BLVRB, CYB5R3
18ubiquinone449.9CYB5R3, MT-CYB, SOD1, GSR
191,3,5-BENZENETRICARBOXYLIC ACID119.9HBA1, HBB
20menadione44 11 2411.9SOD1, HBG2, CYB5A, CYB5R3, GSR
21nitroblue tetrazolium449.9BLVRB, MT-CYB, G6PD, SOD1
22fe2+449.9HBG2, CYB5A, MT-CYB, BLVRB
23riboflavin44 11 2411.9BLVRB, GSR, HBG2
24nadp+449.8G6PD, MT-CYB, GSR, BLVRB
25quinone44 2410.8MT-CYB, CYB5R3, CYB5A, BLVRB
26nitroglycerin44 1110.8BLVRB, GSR, HBG2, SOD1
27malondialdehyde449.8G6PD, GSR, HP, SOD1, HBG2
28uric acid44 2410.8HP, SOD1, GSR, G6PD, HBG2
29mitomycin c449.8CYB5R3, MT-CYB, GSR, CYB5A
30flavin449.7MT-CYB, GSR, CYB5A, CYB5R3, BLVRB
31fe3+449.7BLVRB, HBG2, MT-CYB
32nad+449.7BLVRB, CYB5R3, MT-CYB, G6PD, CYB5A
33oxygen44 2410.7BLVRB, HBB, MT-CYB, HBA1
34tocopherol449.7HBG2, HP, GSR, G6PD, CYB5A, SOD1
35vitamin-e449.7SOD1, CYB5A, GSR, HP, HBG2, G6PD
36carbon449.6CYB5A, HBG2, MT-CYB, BLVRB, G6PD
37SEBACIC ACID119.6HBA1, HBB
38nadph44 2410.6G6PD, HBG2, CYB5R3, MT-CYB, CYB5A, BLVRB
39creatinine449.4G6PD, SOD1, HP, HBG2, MT-CYB, GSR
40lactate449.3HBB, G6PD, SOD1, CYB5A, HP, GSR
41ascorbic acid44 2410.2MT-CYB, G6PD, SOD1, GSR, HBG2, CYB5R3
42heme28 11 2411.1HBB, HBA1, HBG2, BLVRB, MT-CYB, CYB5R4
43superoxide44 2410.1CYB5A, SOD1, G6PD, CYB5R3, MT-CYB, BLVRB
44arginine449.1CYB5R3, HBG2, GSR, HBB, CYB5A, SOD1
45alanine449.1HBB, SOD1, MT-CYB, HBG2, HP, CYB5A
46h2o2448.9CYB5A, HBG2, HBB, MT-CYB, HP, CYB5R3
47lipid448.9G6PD, MT-CYB, SOD1, HP, HBG2, GSR
48iron44 249.8BLVRB, MT-CYB, SOD1, HBB, HBA1, CYB5R3
49nad28 249.6CYB5RL, CYB5R2, CYB5R3, BLVRB, CYB5R1, GSR
50nadh44 11 249.5CYB5R2, CYB5R1, CYB5RL, CYB5R3, CYB5R4, HBG2

GO Terms for genes affiliated with Methemoglobinemia

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16Gene Ontology
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Cellular components related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.0HP, HBB
2hemoglobin complexGO:0058339.7CYB5R3, HBG2, HBB
3haptoglobin-hemoglobin complexGO:0318389.7HP, HBB

Biological processes related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1L-ascorbic acid metabolic processGO:01985210.0CYB5A, CYB5R3
2superoxide metabolic processGO:00680110.0CYB5R4, SOD1
3glutathione metabolic processGO:0067499.9GSR, G6PD, SOD1
4response to hydrogen peroxideGO:0425429.8HP, HBB, SOD1
5sterol biosynthetic processGO:0161269.6CYB5R2, CYB5R1
6oxidation-reduction processGO:0551149.3CYB5R2, CYB5R4, G6PD

Molecular functions related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00534410.0HBG2, HBB
2hemoglobin bindingGO:0304929.7HP, HBB
3heme bindingGO:0200379.4HBB, HBG2, CYB5R4, CYB5A
4cytochrome-b5 reductase activity, acting on NAD(P)HGO:0041288.7CYB5RL, CYB5R1, CYB5R2, CYB5R3, CYB5R4

Products for genes affiliated with Methemoglobinemia

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Sources for Methemoglobinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet