MCID: MTH007
MIFTS: 52

Methemoglobinemia malady

Immune, Blood categories

Summaries for Methemoglobinemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Methemoglobinemia (or methaemoglobinaemia) is a disorder characterized by the presence of a higher than... more...

MalaCards: Methemoglobinemia, also known as methemoglobinemia nos, is related to sulfhemoglobinemia and methemoglobinemia, type iv. An important gene associated with Methemoglobinemia is CYB5R3 (cytochrome b5 reductase 3), and among its related pathways are Vitamin C (ascorbate) metabolism and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs ascorbic acid and methylene blue and the compounds alpha tocopherol and hads have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain.

Aliases & Classifications for Methemoglobinemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

methemoglobinemia 8 10 45 61
methemoglobinemia nos 8
methaemoglobinaemia 8


External Ids:

Disease Ontology8 DOID:10783
ICD9CM27 289.7
MeSH35 D008708
NCIt40 C34817
ICD1025 D74, D74.9

Related Diseases for Methemoglobinemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the methemoglobinemia, type i family:

congenital methemoglobinemia methemoglobinemia
methemoglobinemias, beta- methemoglobinemias, alpha-
methemoglobinemia, type iv methemoglobinemia, type ii

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1sulfhemoglobinemia30.5SHB, HBG2
2methemoglobinemia, type iv30.3HBG2, CYB5R3, CYB5A
3thalassemia30.0G6PD, HBB, HBA1, HBG2
4favism29.8HP, G6PD
5hydrops fetalis29.8HBB
6tuberculosis29.8GSR, HP, HBB
7congenital methemoglobinemia10.8
8methemoglobinemia, type i10.5
9methemoglobinemia beta-globin type10.5
10mental retardation10.4
11hereditary methemoglobinemia, recessive10.3
12autosomal dominant methemoglobinemia10.2
13aspiration pneumonia10.2
14b cell deficiency10.1
15nadh cytochrome b5 reductase deficiency10.1
16hypoxia10.1
17methemoglobinemias, beta-10.1
18methemoglobinemias, alpha-10.1
19methemoglobinemia, type ii10.1
20spastic diplegia10.0
21ankylosis10.0
22temporomandibular ankylosis10.0
23congenital temporomandibular joint ankylosis10.0
24fetal hemoglobin quantitative trait locus 110.0HBG2
25viral hepatitis10.0G6PD
26ariboflavinosis10.0GSR
27blackwater fever10.0G6PD
28galactosemia10.0HP
29iron deficiency anemia10.0HBG2, G6PD
30friedreich ataxia10.0GSR
31pneumonia10.0MT-CYB
32nephrotic syndrome10.0HP
33diabetic cataract10.0G6PD, GSR
34wilson disease10.0G6PD, SOD1
35chronic granulomatous disease10.0MT-CYB
36leishmaniasis10.0MT-CYB
37obesity10.0MT-CYB
38leber hereditary optic neuropathy10.0MT-CYB
39gastric ulcer10.0GSR
40aspergillosis10.0MT-CYB
41septo-optic dysplasia10.0SOD1
42congenital hemolytic anemia10.0HP, G6PD
43bilirubin metabolic disorder10.0HP, HBG2, G6PD
44glucosephosphate dehydrogenase deficiency10.0G6PD, HP, GSR
45acute kidney failure10.0HP, HBG2, G6PD
46chagas disease10.0GSR, MT-CYB
47hyperhomocysteinemia10.0SOD1
48senile cataract10.0SOD1, G6PD, GSR
49cutaneous leishmaniasis10.0MT-CYB, G6PD
50hyperglycemia10.0SOD1, HBA1

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to methemoglobinemia

Clinical Features for Methemoglobinemia

Drugs & Therapeutics for Methemoglobinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Methemoglobinemia

Drug clinical trials:

Search ClinicalTrials for Methemoglobinemia

Search NIH Clinical Center for Methemoglobinemia

Search CenterWatch for Methemoglobinemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Methemoglobinemia

Anatomical Context for Methemoglobinemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Methemoglobinemia:

33
Skin, Liver, Brain, Kidney, Lung, Spleen, Whole blood, Heart, Skeletal muscle, T cells, B lymphoblasts, B cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Methemoglobinemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Methemoglobinemia

Sources:
51PubMed
See all sources

Articles related to Methemoglobinemia:

(show top 50)    (show all 568)
idTitleAuthorsYear
1
Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia]. (23866629)
2013
2
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
3
Late Diagnosis of Congenital Methemoglobinemia in an Elderly Patient During Cardiac Surgery. (23725685)
2013
4
Methemoglobinemia induced by trimethoprim-sulfamethoxazole in a patient with systemic lupus erythematosus. (23903510)
2013
5
Hemolytic anemia and methemoglobinemia in a preterm baby as a complication of antenatal intraamnial injection of toluidine blue. (23519748)
2013
6
ICU management of Methemoglobinemia due to unknown compound poisoning. (23495280)
2013
7
Nail polish remover poisoning: What caused methemoglobinemia? (23580843)
2012
8
Methemoglobinemia in the setting of chronic transdermal lidocaine patch use. (22568708)
2012
9
Atypical presentations of methemoglobinemia from benzocaine spray. (22162610)
2011
10
Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-year-old boy. (21479984)
2011
11
Chocolate-colored blood with normal artery oxygen: methemoglobinemia related to phenazopyridine. (20467292)
2011
12
Prilocain-induced methemoglobinemia after endovenous laser ablation. (20346699)
2010
13
Cyanosis by methemoglobinemia in tadpoles of Cochranella granulosa (Anura: Centrolenidae). (21246999)
2010
14
Pulse-oximetric measurement of prilocaine-induced methemoglobinemia in regional anesthesia. (20705783)
2010
15
Methemoglobinemia due to local anesthesia with prilocaine for circumcision. (20642651)
2010
16
Acquired methemoglobinemia due to contaminated colours: a preventable disaster. (19158164)
2009
17
Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy. (18376092)
2008
18
Zopiclone-associated methemoglobinemia and renal impairment. (18949589)
2008
19
Hemoglobin M variant and congenital methemoglobinemia: methylene blue will not be effective in the presence of hemoglobin M. (18245076)
2008
20
Methemoglobinemia: an industrial outbreak among rubber molding workers. (16688009)
2006
21
Prilocaine induced methemoglobinemia. (16432610)
2006
22
A reader remembers a patient with methemoglobinemia. (16440996)
2006
23
Laboratory assessment of oxygenation in methemoglobinemia. (15514101)
2005
24
Severe methemoglobinemia due to food intoxication in infants. (16096602)
2005
25
Topical anesthesia-induced methemoglobinemia in bariatric surgery patients. (15802075)
2005
26
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. (15342970)
2004
27
Benzocaine induced methemoglobinemia: a potentially fatal complication of transesophageal echocardiography. (22826681)
2003
28
Severe methemoglobinemia from topical anesthetic spray: case report, discussion and qualitative systematic review. (17612444)
2001
29
Seven new mutations in the nicotinamide adenine dinucleotide reduced-cytochrome b(5) reductase gene leading to methemoglobinemia type I. (11159544)
2001
30
Infantile methemoglobinemia: reexamining the role of drinking water nitrates. (10379005)
1999
31
Methemoglobinemia secondary to topical silver nitrate therapy--a case report. (10498367)
1999
32
Molecular mechanism of recessive congenital methemoglobinemia in Chinese pedigrees. (11721467)
1999
33
Toxic Methemoglobinemia Complicating Transesophageal Echocardiography. (11175165)
1999
34
Methemoglobinemia: etiology, pharmacology, and clinical management. (10533013)
1999
35
Extracorporeal circulation increases nitric oxide-induced methemoglobinemia in vivo and in vitro. (9233741)
1997
36
Methemoglobinemia caused by topical benzocaine. (9324196)
1997
37
Methodologic problems encountered with cooximetry in methemoglobinemia. (9298047)
1997
38
Arginine-glutamine replacement at residue 57 of NADH-cytochrome b5 reductase in Chinese hereditary methemoglobinemia. (15622768)
1997
39
Endogenous methemoglobinemia associated with diarrheal disease in infancy. (8811515)
1996
40
Methemoglobinemia from perineal application of an anesthetic cream. (8644973)
1996
41
Methemoglobinemia secondary to cleaning solution ingestion. (8933322)
1996
42
A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia. (7668255)
1995
43
A prospective evaluation of benzocaine-associated methemoglobinemia in human beings. (8092589)
1994
44
Concise review: methemoglobinemia. (8416301)
1993
45
Topical anesthetic-induced methemoglobinemia in sheep: a comparison of benzocaine and lidocaine. (1601230)
1992
46
Primaquine-induced methemoglobinemia during treatment of Pneumocystis carinii pneumonia. (1406874)
1992
47
Methemoglobin reductase (cytochrome b5 reductase) deficiency in congenital methemoglobinemia. (4138943)
1974
48
An enzyme variation in a case of congenital methemoglobinemia. (4354625)
1973
49
The reduction of methemoglobin in erythrocytes of a patient with congenital methemoglobinemia, subjects with erythrocyte glucose-6-phosphate dehydrogenase deficiency, and normal individuals. (13964447)
1963
50
Laboratory and clinical studies in congenital methemoglobinemia. (12993537)
1952

Genetic Variations for Methemoglobinemia

Expression for genes affiliated with Methemoglobinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for genes affiliated with Methemoglobinemia

Sources:
54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Methemoglobinemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Methemoglobinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4510.4G6PD, CYB5A
2hads4510.3HBG2, CYB5R3, CYB5A
3no-dimethylhydroxylamine4510.2G6PD, HBG2, GSR
4ferricyanide4510.2HBG2, CYB5R3, CYB5A
5primaquine50 45 1112.2CYB5R3, HBG2, G6PD
6methylene blue50 4511.2G6PD, BLVRB, CYB5R3
73-amino-1,2,4-triazole4510.1GSR, HBG2, SOD1
8s-nitrosocysteine4510.1HBG2, HBB, SOD1
9dehydroascorbic acid45 1111.1GSR, G6PD, SOD1
10semiquinone4510.0SOD1, MT-CYB, HBG2, CYB5R3
11thiobarbituric acid4510.0SOD1, G6PD, HP, GSR
12sulfamethoxazole hydroxylamine4510.0CYB5A, CYB5R3
13glucose 6-phosphate45 2411.0SOD1, G6PD, HBB, CYB5R3
1423-diphosphoglycerate4510.0G6PD, HBB, HBG2, HP
15fenton4510.0SOD1, MT-CYB, HBG2, GSR
16gssg4510.0SOD1, G6PD, HBG2, GSR
17methylene4510.0G6PD, BLVRB, HBG2, CYB5R3
18ubiquinone459.9SOD1, MT-CYB, CYB5R3, GSR
194-Carboxycinnamic Acid119.9HBA1, HBB
20menadione45 11 2411.9SOD1, HBG2, CYB5R3, CYB5A, GSR
21fe2+459.9MT-CYB, BLVRB, HBG2, CYB5A
22nitroblue tetrazolium459.9SOD1, G6PD, MT-CYB, BLVRB
23riboflavin45 11 2411.9BLVRB, HBG2, GSR
24nadp+459.8G6PD, MT-CYB, BLVRB, GSR
25quinone45 2410.8CYB5A, CYB5R3, BLVRB, MT-CYB
26nitroglycerin45 1110.8SOD1, BLVRB, HBG2, GSR
27malondialdehyde459.8GSR, HP, HBG2, G6PD, SOD1
28uric acid45 2410.8SOD1, G6PD, HBG2, HP, GSR
29mitomycin c459.8GSR, CYB5A, CYB5R3, MT-CYB
308-aminoquinoline459.8HBG2, G6PD
31flavin459.7MT-CYB, BLVRB, CYB5R3, CYB5A, GSR
32fe3+459.7MT-CYB, BLVRB, HBG2
33nad+459.7CYB5A, CYB5R3, BLVRB, MT-CYB, G6PD
34oxygen45 2410.7MT-CYB, BLVRB, HBB, HBA1
35tocopherol459.7SOD1, G6PD, HBG2, CYB5A, HP, GSR
36vitamin-e459.7SOD1, G6PD, HBG2, CYB5A, HP, GSR
37carbon459.6G6PD, MT-CYB, BLVRB, HBG2, CYB5A
38nadph45 2410.6G6PD, MT-CYB, BLVRB, HBG2, CYB5R3, CYB5A
39creatinine459.4SOD1, G6PD, MT-CYB, HBG2, HP, GSR
40lactate459.3SOD1, G6PD, HBB, HBG2, CYB5A, HP
41ascorbic acid45 2410.2SOD1, G6PD, MT-CYB, HBG2, CYB5R3, CYB5A
42heme29 11 2411.1MT-CYB, BLVRB, HBB, HBA1, HBG2, CYB5R4
43superoxide45 2410.1SOD1, G6PD, MT-CYB, BLVRB, HBG2, CYB5R3
44arginine459.1SOD1, BLVRB, HBB, HBG2, CYB5R3, CYB5A
45alanine459.1SOD1, MT-CYB, HBB, HBG2, CYB5A, HP
46h2o2458.9SOD1, G6PD, MT-CYB, HBB, HBG2, CYB5R3
47lipid458.9SOD1, G6PD, MT-CYB, HBG2, CYB5R3, CYB5A
48iron45 249.8SOD1, MT-CYB, BLVRB, HBB, HBA1, HBG2
49nad29 249.6BLVRB, CYB5R4, CYB5R3, CYB5R2, CYB5R1, CYB5RL
50nadh45 11 249.5GSR, SOD1, G6PD, MT-CYB, BLVRB, HBG2

GO Terms for genes affiliated with Methemoglobinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.0HP, HBB
2hemoglobin complexGO:0058339.7CYB5R3, HBG2, HBB
3haptoglobin-hemoglobin complexGO:0318389.7HP, HBB

Biological processes related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1L-ascorbic acid metabolic processGO:01985210.0CYB5A, CYB5R3
2superoxide metabolic processGO:00680110.0CYB5R4, SOD1
3glutathione metabolic processGO:0067499.9GSR, G6PD, SOD1
4response to hydrogen peroxideGO:0425429.8HP, HBB, SOD1
5sterol biosynthetic processGO:0161269.6CYB5R2, CYB5R1
6oxidation-reduction processGO:0551149.3CYB5R2, CYB5R4, G6PD

Molecular functions related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00534410.0HBG2, HBB
2hemoglobin bindingGO:0304929.7HP, HBB
3heme bindingGO:0200379.4HBB, HBG2, CYB5R4, CYB5A
4cytochrome-b5 reductase activity, acting on NAD(P)HGO:0041288.7CYB5RL, CYB5R1, CYB5R2, CYB5R3, CYB5R4

Products for genes affiliated with Methemoglobinemia

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Methemoglobinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet