MCID: MTH007
MIFTS: 55

Methemoglobinemia malady

Immune diseases, Blood diseases categories

Summaries for Methemoglobinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Methemoglobinemia (or methaemoglobinaemia) is a disorder characterized by the presence of a higher than... more...

MalaCards: Methemoglobinemia, also known as methemoglobinemia nos, is related to hemolytic anemia and sulfhemoglobinemia. An important gene associated with Methemoglobinemia is CYB5R3 (cytochrome b5 reductase 3), and among its related pathways are Vitamin C (ascorbate) metabolism and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs ascorbic acid and methylene blue and the compounds alpha tocopherol and hads have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung.

Aliases & Classifications for Methemoglobinemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

methemoglobinemia 8 10 44 60
methemoglobinemia nos 8
methaemoglobinaemia 8


External Ids:

Disease Ontology8 DOID:10783
ICD9CM27 289.7
MeSH34 D008708
NCIt39 C34817
ICD1025 D74, D74.9

Related Diseases for Methemoglobinemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Methemoglobinemia, Type I family:

Congenital Methemoglobinemia methemoglobinemia
Methemoglobinemias, Beta- Methemoglobinemias, Alpha-
Methemoglobinemia, Type Iv Methemoglobinemia, Type Ii

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.5G6PD, HBB, HBG2, HP
2sulfhemoglobinemia30.4SHB, HBG2
3methemoglobinemia, type iv30.2HBG2, CYB5R3, CYB5A
4pneumonia30.1MT-CYB
5malaria30.1G6PD, MT-CYB, HBB, HP, GSR
6favism29.8HP, G6PD
7hyperglycemia29.8SOD1, HBA1
8hemoglobinopathy29.8HP, HBB, G6PD
9tuberculosis29.8GSR, HP, HBB
10congenital methemoglobinemia10.8
11methemoglobinemia beta-globin type10.4
12methemoglobinemia, type i10.4
13diarrhea10.2
14leukemia10.2
15autosomal dominant methemoglobinemia10.2
16aspiration pneumonia10.1
17burns10.1
18hereditary methemoglobinemia, recessive10.1
19pharyngitis10.0
20cervicitis10.0
21leprosy10.0
22respiratory failure10.0
23thalassemia10.0
24vaginitis10.0
25nadh cytochrome b5 reductase deficiency10.0
26methemoglobinemias, beta-10.0
27methemoglobinemias, alpha-10.0
28methemoglobinemia, type ii10.0
29fetal hemoglobin quantitative trait locus 110.0HBG2
30viral hepatitis10.0G6PD
31ariboflavinosis10.0GSR
32blackwater fever10.0G6PD
33galactosemia10.0HP
34iron deficiency anemia10.0HBG2, G6PD
35friedreich ataxia10.0GSR
36nephrotic syndrome10.0HP
37diabetic cataract10.0G6PD, GSR
38wilson disease10.0G6PD, SOD1
39chronic granulomatous disease10.0MT-CYB
40leishmaniasis10.0MT-CYB
41obesity10.0MT-CYB
42leber hereditary optic neuropathy10.0MT-CYB
43gastric ulcer10.0GSR
44aspergillosis10.0MT-CYB
45septo-optic dysplasia10.0SOD1
46congenital hemolytic anemia10.0HP, G6PD
47bilirubin metabolic disorder10.0HP, HBG2, G6PD
48glucosephosphate dehydrogenase deficiency10.0G6PD, HP, GSR
49hydrops fetalis10.0HBB
50acute kidney failure10.0HP, HBG2, G6PD

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to methemoglobinemia

Clinical Features for Methemoglobinemia

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Drugs & Therapeutics for Methemoglobinemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Methemoglobinemia

Drug clinical trials:

Search ClinicalTrials for Methemoglobinemia

Search NIH Clinical Center for Methemoglobinemia

Search CenterWatch for Methemoglobinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Methemoglobinemia

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Anatomical Context for Methemoglobinemia

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32MalaCards
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MalaCards organs/tissues related to Methemoglobinemia:

32
Heart, Kidney, Lung, Spleen, Brain, Liver, Skin, Testes, Whole blood

Animal Models for Methemoglobinemia or affiliated genes

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Publications for Methemoglobinemia

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Sources:
50PubMed
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Articles related to Methemoglobinemia:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Very late recovery of dapsone-induced methemoglobinemia. (24308869)
2014
2
Methemoglobinemia following ingestion of a weedicide. (24346409)
2013
3
Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia. (24317633)
2013
4
Death in an adolescent girl with methemoglobinemia and malaria. (21571786)
2012
5
Molecular basis of two novel mutations found in type I methemoglobinemia. (21349748)
2011
6
Brain iron accumulation in unexplained fetal and infant death victims with smoker mothers--the possible involvement of maternal methemoglobinemia. (21733167)
2011
7
Dapsone-induced methemoglobinemia: a dose-related occurrence? (21246536)
2011
8
Methemoglobinemia induced by 1,2-dichloro-4-nitrobenzene in mice with a disrupted glutathione S-transferase Mu 1 gene. (20562208)
2010
9
Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. (20093649)
2010
10
Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report. (19097728)
2010
11
A 3-year-old boy with fever and oral lesions. Diagnosis: methemoglobinemia. (19968205)
2009
12
Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency: case report and literature review. (19263080)
2009
13
The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats. (18821148)
2008
14
Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient. (18561168)
2008
15
Dapsone-induced methemoglobinemia: case report and literature review. (18090884)
2007
16
Methemoglobinemia and transesophageal echo. (18605250)
2007
17
Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine. (16493607)
2006
18
Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. (16794511)
2006
19
Hyperoxia in lethal methemoglobinemia: effects on oxygen transport, tissue oxygenation, and survival in pigs. (16003066)
2005
20
Methemoglobinemia: sudden dyspnea and oxyhemoglobin desaturation after esophagoduodenoscopy. (15271232)
2004
21
Heterologous expression of enzymopenic methemoglobinemia variants using a novel NADH:cytochrome c reductase fusion protein. (12821320)
2003
22
Suspected methemoglobinemia following awake intubation: one possible effect of benzocaine topical anesthesia--a case report. (12776639)
2003
23
Benzocaine-induced methemoglobinemia: a potentially fatal complication of transesophageal echocardiography. (14677742)
2003
24
Sodium thiosulfate fails to reduce nitrite-induced methemoglobinemia in vitro. (12670840)
2003
25
A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania. (12153765)
2002
26
Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase. (12393396)
2002
27
Methemoglobinemia as a cause of respiratory failure. (11956408)
2002
28
Introduction: congenital methemoglobinemia revisited. (12411314)
2002
29
Use of methylene blue to treat methemoglobinemia in infancy. (12144224)
2001
30
Drug-induced methemoglobinemia during thoracoscopic lung biopsy. (11235734)
2001
31
Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene. (11295830)
2001
32
Methemoglobinemia complicating topical lidocaine used during endoscopic procedures. (11498069)
2001
33
Cause of methemoglobinemia: illness versus nitrate exposure. (11171532)
2001
34
Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets. (10809284)
2000
35
Benzocaine-induced methemoglobinemia. (10653076)
2000
36
Comments on congenital methemoglobinemia. (11105433)
2000
37
Diarrhea and methemoglobinemia in an infant. (11138885)
2000
38
Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide. (11035699)
2000
39
Chloramine-induced methemoglobinemia in a hemodialysis patient. (11014696)
2000
40
Metoclopramide-induced methemoglobinemia in an adult. (10870338)
2000
41
Methemoglobinemia related to topical benzocaine use: is it time to reconsider the empiric use of topical anesthesia before sedated EGD? (11060205)
2000
42
Determination of concentration of cytosolic NADH-cytochrome b5 reductase in erythrocytes from normal Chinese adults, neonates and patients with hereditary methemoglobinemia by double-antibody sandwich ELISA. (9691146)
1998
43
Methemoglobinemia associated with a prilocaine-lidocaine cream. (9114997)
1997
44
Methemoglobinemia: a complication after fiberoptic orotracheal intubation with benzocaine spray. A case report. (7782367)
1995
45
Methemoglobinemia and oxyhemoglobin concentration. (7845050)
1995
46
Fatal methemoglobinemia due to inhalation of isobutyl nitrite. (8145358)
1994
47
Evaluation of the methemoglobinemia associated with sulofenur. (7860238)
1994
48
Incidence of subclinical methemoglobinemia in infants with diarrhea. (8092592)
1994
49
Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation. (6708747)
1984
50
Congenital methemoglobinemia due to hemoglobin M. (4625305)
1972

Genetic Variations for Methemoglobinemia

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Expression for genes affiliated with Methemoglobinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for genes affiliated with Methemoglobinemia

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53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Methemoglobinemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Methemoglobinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.4G6PD, CYB5A
2hads4410.3CYB5A, CYB5R3, HBG2
3no-dimethylhydroxylamine4410.2G6PD, HBG2, GSR
4ferricyanide4410.2CYB5A, HBG2, CYB5R3
5primaquine49 44 1112.2CYB5R3, G6PD, HBG2
6methylene blue49 4411.2BLVRB, CYB5R3, G6PD
73-amino-1,2,4-triazole4410.1SOD1, GSR, HBG2
88-aminoquinoline4410.1G6PD, HBG2
9s-nitrosocysteine4410.1SOD1, HBB, HBG2
10dehydroascorbic acid44 1111.1SOD1, G6PD, GSR
11semiquinone4410.0MT-CYB, SOD1, HBG2, CYB5R3
12thiobarbituric acid4410.0G6PD, HP, SOD1, GSR
13glucose 6-phosphate44 2411.0CYB5R3, G6PD, SOD1, HBB
1423-diphosphoglycerate4410.0HP, HBG2, HBB, G6PD
15fenton4410.0HBG2, GSR, MT-CYB, SOD1
16gssg4410.0GSR, SOD1, G6PD, HBG2
17methylene4410.0HBG2, G6PD, BLVRB, CYB5R3
18ubiquinone449.9CYB5R3, MT-CYB, SOD1, GSR
19menadione44 11 2411.9SOD1, HBG2, CYB5A, CYB5R3, GSR
20nitroblue tetrazolium449.9BLVRB, MT-CYB, G6PD, SOD1
21fe2+449.9HBG2, CYB5A, MT-CYB, BLVRB
22riboflavin44 11 2411.9BLVRB, HBG2, GSR
23nadp+449.8G6PD, MT-CYB, GSR, BLVRB
24quinone44 2410.8MT-CYB, CYB5R3, CYB5A, BLVRB
25nitroglycerin44 1110.8BLVRB, GSR, HBG2, SOD1
26malondialdehyde449.8G6PD, GSR, HP, SOD1, HBG2
27uric acid44 2410.8HP, SOD1, GSR, G6PD, HBG2
284-Carboxycinnamic Acid119.8HBB, HBA1
29mitomycin c449.8MT-CYB, CYB5A, GSR, CYB5R3
30flavin449.7MT-CYB, GSR, CYB5A, CYB5R3, BLVRB
31fe3+449.7HBG2, MT-CYB, BLVRB
32nad+449.7BLVRB, CYB5R3, MT-CYB, G6PD, CYB5A
33oxygen44 2410.7BLVRB, HBB, MT-CYB, HBA1
34tocopherol449.7HBG2, HP, GSR, G6PD, CYB5A, SOD1
35vitamin-e449.7SOD1, CYB5A, GSR, HP, HBG2, G6PD
36carbon449.6CYB5A, HBG2, MT-CYB, BLVRB, G6PD
372-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID119.6HBA1, HBB
38nadph44 2410.6G6PD, HBG2, CYB5R3, MT-CYB, CYB5A, BLVRB
39creatinine449.4G6PD, SOD1, HP, HBG2, MT-CYB, GSR
40lactate449.3HBB, G6PD, SOD1, CYB5A, HP, GSR
41ascorbic acid44 2410.2MT-CYB, G6PD, SOD1, GSR, HBG2, CYB5R3
42heme28 11 2411.1HBB, HBA1, HBG2, BLVRB, MT-CYB, CYB5R4
43superoxide44 2410.1CYB5A, SOD1, G6PD, CYB5R3, MT-CYB, BLVRB
44arginine449.1CYB5R3, HBG2, GSR, HBB, CYB5A, SOD1
45alanine449.1HBB, SOD1, MT-CYB, HBG2, HP, CYB5A
46h2o2448.9CYB5A, HBG2, HBB, MT-CYB, HP, CYB5R3
47lipid448.9G6PD, MT-CYB, HP, SOD1, CYB5A, CYB5R3
48iron44 249.8BLVRB, MT-CYB, SOD1, HBB, HBA1, CYB5R3
49nad28 249.6CYB5RL, CYB5R2, CYB5R3, BLVRB, CYB5R1, GSR
50nadh44 11 249.5CYB5R2, CYB5R1, CYB5RL, CYB5R3, CYB5R4, HBG2

GO Terms for genes affiliated with Methemoglobinemia

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16Gene Ontology
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Cellular components related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.0HP, HBB
2hemoglobin complexGO:0058339.7CYB5R3, HBG2, HBB
3haptoglobin-hemoglobin complexGO:0318389.7HP, HBB

Biological processes related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1L-ascorbic acid metabolic processGO:01985210.0CYB5A, CYB5R3
2superoxide metabolic processGO:00680110.0CYB5R4, SOD1
3glutathione metabolic processGO:0067499.9GSR, G6PD, SOD1
4response to hydrogen peroxideGO:0425429.8HP, HBB, SOD1
5sterol biosynthetic processGO:0161269.6CYB5R2, CYB5R1
6oxidation-reduction processGO:0551149.3CYB5R2, CYB5R4, G6PD

Molecular functions related to Methemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00534410.0HBG2, HBB
2hemoglobin bindingGO:0304929.7HP, HBB
3heme bindingGO:0200379.4HBB, HBG2, CYB5R4, CYB5A
4cytochrome-b5 reductase activity, acting on NAD(P)HGO:0041288.7CYB5RL, CYB5R1, CYB5R2, CYB5R3, CYB5R4

Products for genes affiliated with Methemoglobinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Methemoglobinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet