MCID: MTH007
MIFTS: 45

Methemoglobinemia malady

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Methemoglobinemia

Summaries for Methemoglobinemia

MalaCards based summary : Methemoglobinemia is related to methemoglobinemia, type i and methemoglobinemia, beta-globin type, and has symptoms including cyanosis An important gene associated with Methemoglobinemia is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Glucose / Energy Metabolism. The drugs Epinephrine and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes.

Wikipedia : 71 Methemoglobinemia is a condition caused by elevated levels of methemoglobin in the blood. Methemoglobin... more...

Related Diseases for Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Type Iv Methemoglobinemia, Type I
Congenital Methemoglobinemia Hereditary Methemoglobinemia
Autosomal Recessive Congenital Methemoglobinemia Acquired Methemoglobinemia

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 methemoglobinemia, type i 12.4
2 methemoglobinemia, beta-globin type 12.2
3 methemoglobinemia, type iv 12.2
4 hereditary methemoglobinemia 12.1
5 autosomal recessive congenital methemoglobinemia 12.1
6 acquired methemoglobinemia 12.0
7 congenital methemoglobinemia 12.0
8 sepsis in premature infants 10.2 HBB HBG2
9 isolated atp synthase deficiency 10.2 HBB HBG2
10 cardiomyopathy, dilated, 1w 10.1 G6PD HBB
11 costello syndrome 10.1 HBB HBG2
12 hereditary sensory and autonomic neuropathy type 1e 10.1 CYB5A CYB5R3 HBG2
13 adenosine triphosphate, elevated, of erythrocytes 10.1 G6PD HBG2
14 cutaneous pseudolymphoma 10.1 CYB5R3 G6PD HBG2
15 mental retardation hypocupremia hypobetalipoproteinemia 10.1 G6PD SOD1
16 krauss herman holmes syndrome 10.1 CYP3A4 G6PD
17 hemolytic anemia 10.1
18 tk2-related mitochondrial dna depletion syndrome, myopathic form 10.0 G6PD HBB HBG2
19 fetal hemoglobin quantitative trait locus 1 10.0 G6PD HBB HBG2
20 tracheal cancer 10.0 G6PD HBB HBG2
21 tenosynovitis 10.0 G6PD SOD1
22 heparane sulfamidase deficiency 10.0 HBB HP
23 microphthalmia, syndromic 13 10.0 G6PD HP
24 sulfhemoglobinemia 10.0
25 toxic labyrinthitis 10.0 G6PD HP
26 pyeloureteritis cystica 9.9 G6PD HP
27 diarrhea 9.9
28 larynx sarcoma 9.9 HBB HP
29 geniculate ganglionitis 9.8 G6PD HBB HP
30 pneumonia 9.8
31 leukemia 9.8
32 tendinopathy 9.8 CYB5A CYB5R3 G6PD HBG2 SOD1
33 hepatitis b 9.8 G6PD HBB HP
34 pyelitis 9.8 G6PD HP
35 burns 9.8
36 malaria 9.8
37 leprosy 9.8
38 meningeal melanocytoma 9.7 CYB5R3 G6PD HBB HP
39 endometriosis of uterus 9.7 G6PD HBB HBG2 HP
40 neuronal ceroid-lipofuscinoses 9.7 G6PD HBB HBG2 HP
41 respiratory failure 9.7
42 heart disease 9.7
43 hypoxia 9.7
44 alcohol dependence 9.7
45 vaginitis 9.7
46 pharyngitis 9.7
47 cervicitis 9.7
48 lupus erythematosus 9.7
49 thalassemia 9.7
50 molluscum contagiosum 9.7

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to Methemoglobinemia

Symptoms & Phenotypes for Methemoglobinemia

UMLS symptoms related to Methemoglobinemia:


cyanosis

Drugs & Therapeutics for Methemoglobinemia

Drugs for Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
3
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
4
Prilocaine Approved Phase 4 721-50-6 4906
5 diuretics Phase 4
6 Epinephryl borate Phase 4
7 Natriuretic Agents Phase 4
8 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
9 Racepinephrine Phase 4
10 Anti-Asthmatic Agents Phase 3
11 Autonomic Agents Phase 3
12 Bronchodilator Agents Phase 3
13 Neurotransmitter Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Respiratory System Agents Phase 3
16 Antioxidants Phase 3
17 Endothelium-Dependent Relaxing Factors Phase 3
18 Protective Agents Phase 3
19 Vasodilator Agents Phase 3
20
Primaquine Approved Phase 1 90-34-6 4908
21
Dapsone Approved, Investigational Phase 1 80-08-0 2955
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 1 58-05-9 54575, 6560146 143
24
Methylene blue Investigational Phase 1 61-73-4
25 Anti-Infective Agents Phase 1
26 Antimalarials Phase 1
27 Antiparasitic Agents Phase 1
28 Antiprotozoal Agents Phase 1
29 Anti-Bacterial Agents Phase 1
30 Folic Acid Antagonists Phase 1
31 Vitamin B Complex Phase 1
32 Folate Nutraceutical Phase 1
33 Vitamin B9 Nutraceutical Phase 1
34
Artemether Approved 71963-77-4 119380 68911
35
Lumefantrine Approved 82186-77-4 6437380
36
Lidocaine Approved, Vet_approved 137-58-6 3676
37
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
38 Artemether-lumefantrine combination
39 Anesthetics
40 Adrenergic Agents
41 Adrenergic Agonists
42 Adrenergic alpha-Agonists
43 Adrenergic beta-Agonists
44 Anesthetics, Local
45 Anti-Arrhythmia Agents
46 Central Nervous System Depressants
47 Diuretics, Potassium Sparing
48 Mydriatics
49 Sodium Channel Blockers
50 Vasoconstrictor Agents

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4
2 Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis Recruiting NCT03053388 Phase 3
3 Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Terminated NCT00005776 Phase 3
4 Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Terminated NCT00005773 Phase 3
5 Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery Unknown status NCT01098409 Phase 2
6 Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Recruiting NCT01715883 Phase 2
7 Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Not yet recruiting NCT02863068 Phase 2
8 Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration Completed NCT02493283 Phase 1
9 Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Completed NCT02478281 Phase 1
10 Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects Completed NCT00000740 Phase 1
11 Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency Completed NCT01668433 Phase 1
12 Nitrite Infusion in Healthy Volunteers Completed NCT00103025 Phase 1
13 Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients Unknown status NCT01883713
14 Safety and Efficacy of Primaquine for P. Vivax Unknown status NCT01837992
15 Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis. Completed NCT01766999
16 Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone Completed NCT00993694
17 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics Completed NCT01402869
18 Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria Completed NCT02528279

Search NIH Clinical Center for Methemoglobinemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: methemoglobinemia

Genetic Tests for Methemoglobinemia

Anatomical Context for Methemoglobinemia

MalaCards organs/tissues related to Methemoglobinemia:

39
Kidney, Lung, Testes, Heart, Skin, Brain, Spleen

Publications for Methemoglobinemia

Articles related to Methemoglobinemia:

(show top 50) (show all 669)
id Title Authors Year
1
Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency. ( 27879542 )
2017
2
Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). ( 27879543 )
2017
3
Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency. ( 28078984 )
2017
4
Two cases of methemoglobinemia: In a military community hospital. ( 26884527 )
2016
5
Methemoglobinemia from frozen-dried mudfish contaminated with sodium nitrite. ( 27367334 )
2016
6
Methemoglobinemia due to indoxacarb poisoning: A rare manifestation. ( 27728599 )
2016
7
Acute methemoglobinemia due to ingestion of MAHIA wine brandy. ( 27853037 )
2016
8
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( 27397059 )
2016
9
A 12-Day-Old Boy with Methemoglobinemia After Circumcision with Local Anesthesia (Lidocaine/Prilocaine). ( 27747692 )
2016
10
An Uncommon Complication With Use of Topical Local Anesthetic Agents: Methemoglobinemia. ( 26741955 )
2016
11
Benzocaine-Induced Methemoglobinemia: A Case Report. ( 26957886 )
2016
12
Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis. ( 27424851 )
2016
13
Extreme Methemoglobinemia After Topical Benzocaine: Recognition by Pulse Oximetry. ( 27881239 )
2016
14
Methemoglobinemia due to pesticide poisoning. ( 27728158 )
2016
15
Methemoglobinemia Secondary to Topical Benzocaine Application to Gastrostomy Site. ( 27139292 )
2016
16
Severe Methemoglobinemia due to Sodium Nitrite Poisoning. ( 27563472 )
2016
17
Case Report of Methemoglobinemia in a Toddler Secondary to Topical Dapsone Exposure. ( 27401099 )
2016
18
Rare Case of Methemoglobinemia Complicating Pregnancy. ( 26881158 )
2016
19
I.V. ascorbic acid for treatment of apparent rasburicase-induced methemoglobinemia in a patient with acute kidney injury and assumed glucose-6-phosphate dehydrogenase deficiency. ( 27099330 )
2016
20
Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials. ( 27223244 )
2016
21
Methemoglobinemia Following Monolinuron Ingestion: A Case Report in a Child. ( 27253655 )
2016
22
A case of methemoglobinemia after ingestion of a chlorhexidine in alcohol solution in an alcohol-dependent patient. ( 27232424 )
2016
23
The Beef Jerky Blues: Methemoglobinemia From Home Cured Meat. ( 27749634 )
2016
24
A bedside test for methemoglobinemia, Sri Lanka. ( 27516640 )
2016
25
Role of ascorbic acid in the treatment of methemoglobinemia. ( 27857990 )
2016
26
Detecting Methemoglobinemia in Animals with a Drop of Blood. ( 27930713 )
2016
27
A Rare but Important Clinical Presentation of Induced Methemoglobinemia. ( 27625731 )
2016
28
Topical Benzocaine and Methemoglobinemia. ( 27754990 )
2016
29
Methemoglobinemia Caused by Portable Dialysis in the Critically Ill. ( 27618271 )
2016
30
Significant methemoglobinemia with bovine hemoglobin infusion in a case with severe autoimmune hemolytic anemia. ( 26954456 )
2016
31
Methemoglobinemia Resulting from Exposure in a Confined Space: Exothermic Self-Polymerization of 4,4'-Methylene Diphenyl Diisocyanate (MDI) Material. ( 27624601 )
2016
32
Severe methemoglobinemia caused by continuous lidocaine infusion in a term neonate. ( 28082013 )
2016
33
Accidental Poisoning Resulting in Severe Methemoglobinemia in a 14-year-old Girl. ( 27408417 )
2016
34
A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult. ( 27119769 )
2016
35
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( 27412886 )
2016
36
Recessive congenital methemoglobinemia in immediate generations. ( 27922248 )
2016
37
Rasburicase-induced methemoglobinemia: case report, literature review, and proposed treatment algorithm. ( 27099716 )
2016
38
Nitrobenzene poisoning presenting as methemoglobinemia. ( 27728584 )
2016
39
Methemoglobinemia caused by dapsone overdose: Which treatment is best? ( 27239625 )
2015
40
First case of methemoglobinemia caused by a ClO2 -based household product. ( 26338044 )
2015
41
Methemoglobinemia: A Diagnosis Not to Be Missed. ( 26026842 )
2015
42
1212: METHEMOGLOBINEMIA IN ACETAMINOPHEN OVERDOSE AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY. ( 26570873 )
2015
43
P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. ( 25861488 )
2015
44
Gluten-Related Methemoglobinemia. ( 26348306 )
2015
45
METHEMOGLOBINEMIA--AN ALTERNATIVE TREATMENT MODALITY. ( 26411149 )
2015
46
An unusual complication after permanent pacemaker implantation: Methemoglobinemia. ( 26148080 )
2015
47
Rasburicase-Induced Methemoglobinemia in a Patient with Aggressive Non-Hodgkin's Lymphoma. ( 26334783 )
2015
48
Identifying the Cause of the "Saturation Gap": Two Cases of Dapsone-induced Methemoglobinemia. ( 26134197 )
2015
49
A Case Report of Prilocaine-Induced Methemoglobinemia after Liposuction Procedure. ( 26199764 )
2015
50
Acute Poisoning with Dapsone and Olanzapine: Severe Methemoglobinemia and Coma with a Favourable Outcome. ( 26933782 )
2015

Variations for Methemoglobinemia

Expression for Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for Methemoglobinemia

Pathways related to Methemoglobinemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 CYB5A CYB5R3 CYB5R4 CYP2E1 CYP3A4
2 12.08 CYP3A4 G6PD HBB
3
Show member pathways
11.26 CYP2E1 CYP3A4
4
Show member pathways
11.2 CYP2E1 CYP3A4
5
Show member pathways
10.95 CYB5R4 HBB
6 10.91 CYP2E1 CYP3A4
7
Show member pathways
10.75 CYP2E1 CYP3A4
8 10.64 CYP2E1 CYP3A4
9 10.46 CYP2E1 CYP3A4
10 9.4 CYB5A CYB5R3 G6PD

GO Terms for Methemoglobinemia

Cellular components related to Methemoglobinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.8 CYB5A CYB5R3 CYB5R4 CYP2E1 CYP3A4
2 intracellular membrane-bounded organelle GO:0043231 9.73 CYB5A CYP2E1 CYP3A4 G6PD
3 endoplasmic reticulum membrane GO:0005789 9.72 CYB5A CYB5R3 CYB5R4 CYP2E1 CYP3A4
4 blood microparticle GO:0072562 9.54 HBB HBG2 HP
5 tertiary granule lumen GO:1904724 9.46 HBB HP
6 organelle membrane GO:0031090 9.33 CYB5A CYP2E1 CYP3A4
7 endocytic vesicle lumen GO:0071682 9.26 HBB HP
8 haptoglobin-hemoglobin complex GO:0031838 8.96 HBB HP
9 hemoglobin complex GO:0005833 8.8 CYB5R3 HBB HBG2

Biological processes related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.61 CYP2E1 G6PD SOD1
2 steroid metabolic process GO:0008202 9.58 CYB5R3 CYP2E1 CYP3A4
3 bicarbonate transport GO:0015701 9.56 CYB5R4 HBB
4 glutathione metabolic process GO:0006749 9.55 G6PD SOD1
5 positive regulation of cell death GO:0010942 9.54 HBB HP
6 cholesterol biosynthetic process GO:0006695 9.52 CYB5R3 G6PD
7 response to antibiotic GO:0046677 9.51 CYB5R4 SOD1
8 xenobiotic metabolic process GO:0006805 9.5 CYB5R3 CYP2E1 CYP3A4
9 drug metabolic process GO:0017144 9.49 CYP2E1 CYP3A4
10 superoxide metabolic process GO:0006801 9.48 CYB5R4 SOD1
11 oxygen transport GO:0015671 9.46 HBB HBG2
12 L-ascorbic acid metabolic process GO:0019852 9.37 CYB5A CYB5R3
13 heterocycle metabolic process GO:0046483 9.26 CYP2E1 CYP3A4
14 oxidation-reduction process GO:0055114 9.17 CYB5A CYB5R3 CYB5R4 CYP2E1 CYP3A4 G6PD
15 monoterpenoid metabolic process GO:0016098 9.16 CYP2E1 CYP3A4
16 response to hydrogen peroxide GO:0042542 9.13 HBB HP SOD1

Molecular functions related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 CYB5A CYP2E1 CYP3A4 SOD1
2 oxidoreductase activity GO:0016491 9.63 CYB5R3 CYB5R4 CYP2E1 CYP3A4 G6PD SOD1
3 iron ion binding GO:0005506 9.56 CYP2E1 CYP3A4 HBB HBG2
4 monooxygenase activity GO:0004497 9.51 CYP2E1 CYP3A4
5 antioxidant activity GO:0016209 9.48 HP SOD1
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.46 CYP2E1 CYP3A4
7 oxygen transporter activity GO:0005344 9.43 HBB HBG2
8 cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 9.37 CYB5R3 CYB5R4
9 hemoglobin binding GO:0030492 9.32 HBB HP
10 oxygen binding GO:0019825 9.26 CYP2E1 CYP3A4 HBB HBG2
11 heme binding GO:0020037 9.1 CYB5A CYB5R4 CYP2E1 CYP3A4 HBB HBG2
12 metal ion binding GO:0046872 10.04 CYB5A CYB5R4 CYP2E1 CYP3A4 HBB HBG2

Sources for Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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