MCID: MTH007
MIFTS: 44

Methemoglobinemia

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Methemoglobinemia

Summaries for Methemoglobinemia

MalaCards based summary : Methemoglobinemia is related to hepatitis and methemoglobinemia, type i, and has symptoms including cyanosis An important gene associated with Methemoglobinemia is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Glucose / Energy Metabolism. The drugs Epinephrine and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney.

Wikipedia : 72 Methemoglobinemia is a condition caused by elevated levels of methemoglobin in the blood. Methemoglobin... more...

Related Diseases for Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Type Iv Methemoglobinemia, Type I
Congenital Methemoglobinemia Hereditary Methemoglobinemia
Acquired Methemoglobinemia

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.0 G6PD HBB HP
2 methemoglobinemia, type i 12.4
3 hereditary methemoglobinemia 12.3
4 methemoglobinemia, beta-globin type 12.2
5 methemoglobinemia, type iv 12.2
6 acquired methemoglobinemia 12.0
7 congenital methemoglobinemia 11.9
8 hepatitis b reinfection following liver transplantation 10.5 HBB HBG2
9 unclassified vasculitis 10.5 HBB HBG2
10 cyanosis, transient neonatal 10.4 HBB HBG2
11 nephrotic syndrome 14 10.4 G6PD HBB
12 pyruvate kinase deficiency 10.4 G6PD HBG2
13 hereditary orotic aciduria without megaloblastic anaemia 10.3 CYB5A CYB5R3 HBG2
14 kozlowski brown hardwick syndrome 10.3 CYP3A4 G6PD
15 hemorrhagic fever 10.3 HBB HP
16 acute radiation syndrome 10.2 CYB5R3 G6PD HBG2
17 toxic labyrinthitis 10.2 G6PD HP
18 microphthalmia, syndromic 13 10.2 G6PD HP
19 classic progressive supranuclear palsy syndrome 10.1 CYP2E1 NAT2
20 thalassemia-beta, dominant inclusion-body 10.1 HBB HBG2
21 spastic paraplegia 8 10.1 G6PD HBB HBG2
22 pyeloureteritis cystica 10.1 G6PD HP
23 sickle cell anemia 10.1 G6PD HBB HBG2
24 hemolytic anemia 10.1
25 endometrial adenocarcinoma 10.0 HBB HP
26 pyelitis 10.0 G6PD HP
27 emery-dreifuss muscular dystrophy, dominant type 10.0 CYP2E1 NAT2
28 hemoglobin h disease, nondeletional 10.0 G6PD HBB
29 sulfhemoglobinemia 10.0
30 mental retardation cataracts calcified pinnae myopathy 9.9 G6PD SOD1
31 adult malignant mesenchymoma 9.9 G6PD HBB HP
32 diarrhea 9.9
33 geniculate ganglionitis 9.9 G6PD HBB HP
34 cervical incompetence 9.8 G6PD SOD1
35 malaria 9.8
36 pneumonia 9.8
37 leukemia 9.8
38 alpha 1-antitrypsin deficiency 9.8 CYP2E1 NAT2
39 burns 9.8
40 leprosy 9.8
41 respiratory failure 9.7
42 heart disease 9.7
43 hypoxia 9.7
44 alcohol dependence 9.7
45 vaginitis 9.7
46 pharyngitis 9.7
47 thalassemia 9.7
48 cervicitis 9.7
49 lupus erythematosus 9.7
50 molluscum contagiosum 9.7

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to Methemoglobinemia

Symptoms & Phenotypes for Methemoglobinemia

UMLS symptoms related to Methemoglobinemia:


cyanosis

Drugs & Therapeutics for Methemoglobinemia

Drugs for Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
3
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
4
Prilocaine Approved Phase 4 721-50-6 4906
5 Racepinephrine Approved Phase 4
6 diuretics Phase 4
7 Epinephryl borate Phase 4
8 Natriuretic Agents Phase 4
9 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
10 Anti-Asthmatic Agents Phase 3
11 Autonomic Agents Phase 3
12 Bronchodilator Agents Phase 3
13 Neurotransmitter Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Respiratory System Agents Phase 3
16 Antioxidants Phase 3
17 Endothelium-Dependent Relaxing Factors Phase 3
18 Protective Agents Phase 3
19 Vasodilator Agents Phase 3
20
Primaquine Approved Phase 1 90-34-6 4908
21
Dapsone Approved, Investigational Phase 1 80-08-0 2955
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
24
Methylene blue Investigational Phase 1 61-73-4
25 Anti-Infective Agents Phase 1
26 Antimalarials Phase 1
27 Antiparasitic Agents Phase 1
28 Antiprotozoal Agents Phase 1
29 Anti-Bacterial Agents Phase 1
30 Folic Acid Antagonists Phase 1
31 Vitamin B Complex Phase 1
32 Folate Nutraceutical Phase 1
33 Vitamin B9 Nutraceutical Phase 1
34
Artemether Approved 71963-77-4 119380 68911
35
Lumefantrine Approved 82186-77-4 6437380
36
Lidocaine Approved, Vet_approved 137-58-6 3676
37
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
38 Artemether-lumefantrine combination
39 Anesthetics
40 Adrenergic Agents
41 Adrenergic Agonists
42 Adrenergic alpha-Agonists
43 Adrenergic beta-Agonists
44 Anesthetics, Local
45 Anti-Arrhythmia Agents
46 Central Nervous System Depressants
47 Diuretics, Potassium Sparing
48 Mydriatics
49 Sodium Channel Blockers
50 Vasoconstrictor Agents

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
2 Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis Recruiting NCT03053388 Phase 3 Nitric Oxide
3 Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Terminated NCT00005776 Phase 3 Inhaled nitric oxide;Placebo
4 Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Terminated NCT00005773 Phase 3 Inhaled Nitric Oxide;Standard iNO therapy
5 Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery Unknown status NCT01098409 Phase 2 sodium nitrite;0.9% sodium chloride
6 Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Recruiting NCT02863068 Phase 2 Topical Sodium Nitrite
7 Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Terminated NCT01715883 Phase 2 Sodium Nitrite
8 Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration Completed NCT02493283 Phase 1 Dapsone single dose;Dapsone multiple dose
9 Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Completed NCT02478281 Phase 1 Methylene Blue
10 Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects Completed NCT00000740 Phase 1 Sitamaquine
11 Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency Completed NCT01668433 Phase 1 Regimens (Primaquine, Methylene blue)
12 Nitrite Infusion in Healthy Volunteers Completed NCT00103025 Phase 1 Sodium Nitrite;Sodium Nitrite Injection
13 Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients Unknown status NCT01883713
14 Safety and Efficacy of Primaquine for P. Vivax Unknown status NCT01837992 Primaquine;delayed primaquine
15 Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis. Completed NCT01766999
16 Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone Completed NCT00993694 chemotherapy;dapsone
17 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics Completed NCT01402869 4% prilocaine plain;2% Lidocaine with 1:100,000 epinephrine
18 Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria Completed NCT02528279 Coartem

Search NIH Clinical Center for Methemoglobinemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: methemoglobinemia

Genetic Tests for Methemoglobinemia

Anatomical Context for Methemoglobinemia

MalaCards organs/tissues related to Methemoglobinemia:

39
Lung, Heart, Kidney, Testes, Skin, Liver, Brain

Publications for Methemoglobinemia

Articles related to Methemoglobinemia:

(show top 50) (show all 690)
id Title Authors Year
1
Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia. ( 28370399 )
2017
2
Rasburicase-induced methemoglobinemia: The eyes do not see what the mind does not know. ( 28345492 )
2017
3
Methemoglobinemia Caused by Indoxacarb Poisoning. ( 28641724 )
2017
4
An Unusual Case of Neonatal Methemoglobinemia. ( 28285300 )
2017
5
Upward trend of dapsone-induced methemoglobinemia in renal transplant communitya8c. ( 28699887 )
2017
6
Hemolysis and Methemoglobinemia in a Child With Membrane Oxygenator on Biventricular Assist Device. ( 28782159 )
2017
7
Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency. ( 28078984 )
2017
8
Successful treatment of NO-induced methemoglobinemia with low-dose vitamin C. ( 28438052 )
2017
9
Methemoglobinemia: Living with Dormant Devil. ( 28428705 )
2017
10
Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency. ( 27879542 )
2017
11
Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). ( 27879543 )
2017
12
A Case of Methemoglobinemia Successfully Treated with Hyperbaric Oxygenation Monotherapy. ( 28838565 )
2017
13
A Case Report of Benzocaine-Induced Methemoglobinemia. ( 28803519 )
2017
14
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion. ( 28911028 )
2017
15
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( 28875384 )
2017
16
Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due to Plasmodium vivax in the Brazilian Amazon Basin. ( 28440745 )
2017
17
A puzzling case of methemoglobinemia. ( 28370418 )
2017
18
Prilocaine-induced Methemoglobinemia. ( 28903852 )
2017
19
Inhaled nitric oxide, methemoglobinemia, and route of delivery. ( 28757849 )
2017
20
A Case of Cyanosis: Dapsone Induced Methemoglobinemia and Coexisting Pulmonary Embolism. ( 28418946 )
2017
21
Plasmapheresis in severe methemoglobinemia following occupational exposure. ( 28259531 )
2017
22
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. ( 28765205 )
2017
23
Acquired Methemoglobinemia - A Sporadic Holi Disaster. ( 28667718 )
2017
24
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( 27412886 )
2016
25
Methemoglobinemia Resulting from Exposure in a Confined Space: Exothermic Self-Polymerization of 4,4'-Methylene Diphenyl Diisocyanate (MDI) Material. ( 27624601 )
2016
26
Recessive congenital methemoglobinemia in immediate generations. ( 27922248 )
2016
27
Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis. ( 27424851 )
2016
28
Benzocaine-Induced Methemoglobinemia: A Case Report. ( 26957886 )
2016
29
Rare Case of Methemoglobinemia Complicating Pregnancy. ( 26881158 )
2016
30
Acute methemoglobinemia due to ingestion of MAHIA wine brandy. ( 27853037 )
2016
31
Accidental Poisoning Resulting in Severe Methemoglobinemia in a 14-year-old Girl. ( 27408417 )
2016
32
Rasburicase-induced methemoglobinemia: case report, literature review, and proposed treatment algorithm. ( 27099716 )
2016
33
I.V. ascorbic acid for treatment of apparent rasburicase-induced methemoglobinemia in a patient with acute kidney injury and assumed glucose-6-phosphate dehydrogenase deficiency. ( 27099330 )
2016
34
A Rare but Important Clinical Presentation of Induced Methemoglobinemia. ( 27625731 )
2016
35
The Beef Jerky Blues: Methemoglobinemia From Home Cured Meat. ( 27749634 )
2016
36
Methemoglobinemia Following Monolinuron Ingestion: A Case Report in a Child. ( 27253655 )
2016
37
A 12-Day-Old Boy with Methemoglobinemia After Circumcision with Local Anesthesia (Lidocaine/Prilocaine). ( 27747692 )
2016
38
Methemoglobinemia Secondary to Topical Benzocaine Application to Gastrostomy Site. ( 27139292 )
2016
39
A case of methemoglobinemia after ingestion of a chlorhexidine in alcohol solution in an alcohol-dependent patient. ( 27232424 )
2016
40
Severe methemoglobinemia caused by continuous lidocaine infusion in a term neonate. ( 28082013 )
2016
41
Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials. ( 27223244 )
2016
42
A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult. ( 27119769 )
2016
43
Nitrobenzene poisoning presenting as methemoglobinemia. ( 27728584 )
2016
44
Severe Methemoglobinemia due to Sodium Nitrite Poisoning. ( 27563472 )
2016
45
Role of ascorbic acid in the treatment of methemoglobinemia. ( 27857990 )
2016
46
Methemoglobinemia from frozen-dried mudfish contaminated with sodium nitrite. ( 27367334 )
2016
47
Case Report of Methemoglobinemia in a Toddler Secondary to Topical Dapsone Exposure. ( 27401099 )
2016
48
Two cases of methemoglobinemia: In a military community hospital. ( 26884527 )
2016
49
Methemoglobinemia due to indoxacarb poisoning: A rare manifestation. ( 27728599 )
2016
50
Methemoglobinemia Caused by Portable Dialysis in the Critically Ill. ( 27618271 )
2016

Variations for Methemoglobinemia

Expression for Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for Methemoglobinemia

Pathways related to Methemoglobinemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 CYB5A CYB5R3 CYP2E1 CYP3A4 NAT2
2 12.05 CYP3A4 G6PD HBB
3
Show member pathways
11.28 CYP2E1 CYP3A4
4
Show member pathways
11.24 CYP2E1 CYP3A4
5
Show member pathways
11.18 CYP2E1 CYP3A4
6 10.91 CYP2E1 CYP3A4
7 10.7 CYP2E1 CYP3A4
8 10.56 CYP2E1 CYP3A4
9
Show member pathways
10.56 CYP2E1 CYP3A4 NAT2
10 9.4 CYB5A CYB5R3 G6PD

GO Terms for Methemoglobinemia

Cellular components related to Methemoglobinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.67 CYB5A CYP2E1 CYP3A4 G6PD
2 blood microparticle GO:0072562 9.5 HBB HBG2 HP
3 tertiary granule lumen GO:1904724 9.4 HBB HP
4 organelle membrane GO:0031090 9.33 CYB5A CYP2E1 CYP3A4
5 endocytic vesicle lumen GO:0071682 9.26 HBB HP
6 haptoglobin-hemoglobin complex GO:0031838 8.96 HBB HP
7 hemoglobin complex GO:0005833 8.8 CYB5R3 HBB HBG2

Biological processes related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.61 CYP2E1 G6PD SOD1
2 steroid metabolic process GO:0008202 9.58 CYB5R3 CYP2E1 CYP3A4
3 glutathione metabolic process GO:0006749 9.52 G6PD SOD1
4 positive regulation of cell death GO:0010942 9.51 HBB HP
5 cholesterol biosynthetic process GO:0006695 9.49 CYB5R3 G6PD
6 drug metabolic process GO:0017144 9.48 CYP2E1 CYP3A4
7 oxygen transport GO:0015671 9.46 HBB HBG2
8 oxidation-reduction process GO:0055114 9.43 CYB5A CYB5R3 CYP2E1 CYP3A4 G6PD SOD1
9 L-ascorbic acid metabolic process GO:0019852 9.37 CYB5A CYB5R3
10 response to hydrogen peroxide GO:0042542 9.33 HBB HP SOD1
11 heterocycle metabolic process GO:0046483 9.32 CYP2E1 CYP3A4
12 monoterpenoid metabolic process GO:0016098 9.26 CYP2E1 CYP3A4
13 xenobiotic metabolic process GO:0006805 8.92 CYB5R3 CYP2E1 CYP3A4 NAT2

Molecular functions related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.72 CYB5R3 CYP2E1 CYP3A4 G6PD SOD1
2 enzyme binding GO:0019899 9.67 CYB5A CYP2E1 CYP3A4 SOD1
3 monooxygenase activity GO:0004497 9.49 CYP2E1 CYP3A4
4 antioxidant activity GO:0016209 9.46 HP SOD1
5 iron ion binding GO:0005506 9.46 CYP2E1 CYP3A4 HBB HBG2
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.43 CYP2E1 CYP3A4
7 oxygen transporter activity GO:0005344 9.4 HBB HBG2
8 hemoglobin binding GO:0030492 9.26 HBB HP
9 oxygen binding GO:0019825 9.26 CYP2E1 CYP3A4 HBB HBG2
10 steroid hydroxylase activity GO:0008395 9.18 CYP3A4
11 heme binding GO:0020037 9.02 CYB5A CYP2E1 CYP3A4 HBB HBG2

Sources for Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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