MCID: MCR019
MIFTS: 37

Microglandular Adenosis malady

Aliases & Classifications for Microglandular Adenosis

Aliases & Descriptions for Microglandular Adenosis:

Name: Microglandular Adenosis 12 14
Fibrocystic Breast Disease 42
Breast Fibrocystic Disease 69
Adenosis of the Breast 12
Adenosis of Breast 69
Adenosis - Breast 12

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Disease Ontology 12 DOID:5998
MeSH 42 D005348
NCIt 47 C3484
SNOMED-CT 64 270893004
UMLS 69 C0085750

Summaries for Microglandular Adenosis

MalaCards based summary : Microglandular Adenosis, also known as fibrocystic breast disease, is related to tubular adenocarcinoma and microglandular adenosis of breast. An important gene associated with Microglandular Adenosis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Glioma and Proteoglycans in cancer. The drugs Tamoxifen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are Increased cell death HMECs cells and embryo

Related Diseases for Microglandular Adenosis

Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 tubular adenocarcinoma 30.1 ESR1 PIP
2 microglandular adenosis of breast 12.1
3 fibrosclerosis of breast 11.1
4 apocrine adenosis of breast 11.0
5 breast adenomyoepithelial adenosis 10.9
6 sclerosing adenosis of breast 10.9
7 breast disease 10.4
8 mouth disease 10.2 ERBB2 PGR
9 mucoepidermoid thyroid carcinoma 10.2 ERBB2 PGR
10 triple-receptor negative breast cancer 10.2 ERBB2 PGR
11 skin sarcoma 10.2 ERBB2 PGR
12 breast cancer 10.2
13 intestinal neuroendocrine benign tumor 10.2 ERBB2 PGR
14 bartholin's gland benign neoplasm 10.2 ESR1 PGR
15 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
16 appendix leiomyoma 10.2 ESR1 PGR
17 basaloid squamous cell carcinoma 10.2 ERBB2 PGR
18 bronchus adenoma 10.2 ESR1 PGR
19 ovarian benign neoplasm 10.2 ESR1 PGR
20 plexiform neurofibroma 10.2 ESR1 PGR
21 infiltrating angiolipoma 10.2 ERBB2 PGR
22 paranasal sinus disease 10.2 ESR1 PGR
23 deafness, autosomal recessive 21 10.2 ESR1 PGR
24 atypical lipomatous tumor 10.2 ESR1 PGR
25 pediatric intraocular retinoblastoma 10.2 ESR1 PGR
26 congenital disorder of glycosylation, type ic 10.2 ESR1 PGR
27 intestinal perforation 10.2 ESR1 PGR
28 perlman syndrome 10.2 ESR1 PGR
29 vulvar squamous papilloma 10.2 ESR1 S100B
30 breast sarcoma 10.2 ERBB2 PIP
31 bladder adenocarcinoma 10.2 ESR1 PGR
32 anal neuroendocrine tumor 10.2 ESR1 PGR
33 osteogenesis imperfecta 10.2 ESR1 PGR
34 vulva basal cell carcinoma 10.2 ESR1 PGR
35 intraneural perineurioma 10.2 ESR1 PGR
36 middle ear adenocarcinoma 10.2 ESR1 PGR
37 hereditary breast ovarian cancer 10.2 ERBB2 ESR1
38 acute thyroiditis 10.2 ESR1 PGR
39 osteochondrodysplasia 10.2 ESR1 S100B
40 aortitis 10.2 PGR TP53
41 mucoepidermoid esophageal carcinoma 10.2 ESR1 PGR
42 hemangioma of liver 10.2 S100B TP53
43 perinatal jaundice due to hepatocellular damage 10.2 ESR1 PGR
44 conjunctival cancer 10.2 S100B TP53
45 pericardium leiomyoma 10.2 PGR TP53
46 deafness, autosomal recessive 74 10.2 ESR1 PGR
47 adult neuronal ceroid lipofuscinosis 10.2 ESR1 PGR
48 vulva squamous cell carcinoma 10.1 ERBB2 PIP
49 breast ductal carcinoma 10.1 PGR TP53
50 angiolipomatosis, familial 10.1 ERBB2 PIP

Comorbidity relations with Microglandular Adenosis via Phenotypic Disease Network (PDN):


Breast Fibroadenosis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Hypothyroidism Mastitis

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to Microglandular Adenosis

Symptoms & Phenotypes for Microglandular Adenosis

GenomeRNAi Phenotypes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.92 KRT18 PGR PIP TP53

MGI Mouse Phenotypes related to Microglandular Adenosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.8 ERBB2 ESR1 KRT18 PGR TP53
2 endocrine/exocrine gland MP:0005379 9.77 TP53 ERBB2 ESR1 PGR PIP
3 integument MP:0010771 9.72 ERBB2 ESR1 PGR S100B TP53
4 limbs/digits/tail MP:0005371 9.56 ERBB2 ESR1 PGR TP53
5 neoplasm MP:0002006 9.46 ERBB2 ESR1 PGR TP53
6 normal MP:0002873 9.35 ERBB2 ESR1 PGR S100B TP53
7 reproductive system MP:0005389 9.02 ERBB2 ESR1 PGR PIP TP53

Drugs & Therapeutics for Microglandular Adenosis

Drugs for Microglandular Adenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antimetabolites Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antirheumatic Agents Phase 4
9 Bone Density Conservation Agents Phase 4
10 Dermatologic Agents Phase 4
11 Efamol Phase 4
12 Estrogen Antagonists Phase 4,Phase 2
13 Estrogen Receptor Modulators Phase 4,Phase 2
14 Estrogens Phase 4,Phase 2
15 Hormone Antagonists Phase 4,Phase 2
16 Hormones Phase 4,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Selective Estrogen Receptor Modulators Phase 4
22 Evening Primrose Nutraceutical Phase 4
23 Anti-Infective Agents Phase 3
24 Anti-Infective Agents, Local Phase 3
25 cadexomer iodine Phase 3
26
Iodine Phase 3 7553-56-2 807
27 Micronutrients Phase 3
28 Trace Elements Phase 3
29
Danazol Approved Phase 2 17230-88-5 28417
30 Omega 3 Fatty Acid Nutraceutical Phase 2
31
Ethanol Approved 64-17-5 702
32
Progesterone Approved, Vet_approved 57-83-0 5994
33
Zinc Approved 7440-66-6 32051 23994
34
Cholecalciferol Approved, Nutraceutical 67-97-0 6221 10883523 5280795
35
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
36 Antibodies
37 Immunoglobulins
38 Liver Extracts
39 Ergocalciferols
40 vitamin d
41 Vitamins
42 Autoantibodies
43 Calciferol Nutraceutical
44 Vitamin D2 Nutraceutical

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4
2 A Clinical Study on the Efficacy and Safety of the Treatment of Hyperplasia of Mammary Glands With Xiaoru Sanjie Capsule Recruiting NCT02929420 Phase 4
3 Study for Treatment of Moderate or Severe, Periodic, "Cyclic", Breast Pain Unknown status NCT00237523 Phase 3
4 Efficacy and Safety of ONCOXIN in Patients With Breast Fibrocystic Disease Completed NCT00967681 Phase 3
5 Diet and Breast Cancer Prevention Trial Completed NCT00148057 Phase 3
6 A Study of Topical Danazol for the Treatment of Pain Associated With Fibrocystic Breast Disease Completed NCT00744276 Phase 2
7 Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema Completed NCT02002403 Phase 2
8 An Open-Label, MultiCenter Evaluation of the Use of Topically Administered FP1198 in Subjects With Pain Associated With Cyclic Mastalgia Completed NCT01105793 Phase 2
9 Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors Active, not recruiting NCT01849250 Phase 2
10 China CellSearch Study Unknown status NCT01116869
11 Clinical Trial of Quantitative Detection Kit for Hsp90α in Breast Cancer Unknown status NCT02324101
12 Women At Risk: The High Risk Breast Cancer Program Unknown status NCT01034891
13 Prolactin Receptor and Breast Diseases Completed NCT00842465
14 Nuclear Morphology of Breast Cells in Ductal Lavage Completed NCT00259597
15 Genetics of Mammographic Appearances and Patterns (The GenMap Study) Completed NCT01160510
16 A Comparison of Breast Tomosynthesis Mammography and Conventional Breast Imaging in the Characterization of Breast Masses Completed NCT00826488 Early Phase 1
17 The Ghana Breast Health Study Completed NCT01661023
18 Breast Cancer, Breast Disease, and Pesticides Completed NCT00341315
19 Markers for Breast Cancer Completed NCT00339248
20 The Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA-15-3 is a Reliable Biomarker of Breast Cancer Completed NCT01643148
21 Study of Urine Samples From Women With Newly Diagnosed Breast Cancer Enrolled on Clinical Trial UNMC-08105 Completed NCT00959244
22 Comparison of MRI and Molecular Breast Imaging in Breast Diagnostic Evaluation Completed NCT00591864
23 UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource Recruiting NCT01401998
24 Johns Hopkins Breast Cancer Program Longitudinal Repository Recruiting NCT01937039
25 Diagnostic Performance of an Automated Breast Ultrasound System (ABUS) Recruiting NCT02661204
26 Studying Blood and Tumor Tissue Samples in Women With Invasive Breast Cancer, Ductal or Lobular Carcinoma in Situ, or Benign Breast Disease Active, not recruiting NCT00898508
27 A Randomized Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Safety, Tolerability and Potential Effects of the Dietary Supplement Violet™ Molecular Iodine (I2) on Breast Health in Women With Cyclic Breast Discomfort and Tenderness Active, not recruiting NCT02676336
28 Clinical and Molecular Investigations Into Ciliopathies Active, not recruiting NCT00068224
29 VITamin D and OmegA-3 TriaL: Effects on Mammographic Density and Breast Tissue Enrolling by invitation NCT02239874
30 Cystic Breast Masses by Contrast Enhanced Ultrasound (CEUS) Not yet recruiting NCT02887937
31 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Not yet recruiting NCT02066025
32 Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease Terminated NCT00813878
33 Involvement of Endogenous Digitalis-like Compounds in Breast Cancer Withdrawn NCT00310882
34 Deep Sequencing of the Breast Cancer Transcriptome Withdrawn NCT01141530

Search NIH Clinical Center for Microglandular Adenosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: fibrocystic breast disease

Genetic Tests for Microglandular Adenosis

Anatomical Context for Microglandular Adenosis

MalaCards organs/tissues related to Microglandular Adenosis:

39
Breast

Publications for Microglandular Adenosis

Articles related to Microglandular Adenosis:

(show all 39)
id Title Authors Year
1
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family. ( 27713419 )
2017
2
Atypical microglandular adenosis post-neoadjuvant chemotherapy. ( 27773126 )
2016
3
Microglandular adenosis: a prime suspect in triple-negative breast cancer development. ( 27061094 )
2016
4
Breast atypical microglandular adenosis can be a diagnostic pitfall on fine-needle aspiration samples. ( 26991047 )
2016
5
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations. ( 26806567 )
2016
6
Vulval Microglandular Adenosis-like Neoplasm With Chondromyxoid Stroma: Report of a Unique Case. ( 26535982 )
2015
7
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. ( 25337263 )
2014
8
Invasive breast carcinoma arising in microglandular adenosis: two case reports. ( 24454466 )
2013
9
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? ( 23584829 )
2013
10
Acinic cell carcinoma of the breast arising in microglandular adenosis. ( 24369519 )
2013
11
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. ( 22486256 )
2012
12
Microglandular adenosis with transition to breast carcinoma: a series of three cases. ( 21753716 )
2011
13
Microglandular adenosis. ( 21847399 )
2011
14
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. ( 20846267 )
2010
15
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. ( 20922408 )
2010
16
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. ( 19824997 )
2009
17
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. ( 19047897 )
2009
18
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. ( 19922592 )
2009
19
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. ( 18300793 )
2008
20
Breast carcinoma arising in microglandular adenosis: a review of the literature. ( 17824796 )
2007
21
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. ( 15129910 )
2004
22
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. ( 12521372 )
2003
23
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. ( 12883237 )
2003
24
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. ( 12042957 )
2002
25
[Mammary carcinoma arising in microglandular adenosis: a case report]. ( 11852363 )
2001
26
Carcinoma arising in microglandular adenosis of the breast. ( 12574855 )
2001
27
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. ( 11494007 )
2000
28
Microglandular adenosis arising in a chronic paranasal sinusitis. ( 11150125 )
2000
29
Microglandular adenosis arising in chronic paranasal sinusitis. ( 10841649 )
2000
30
Carcinoma of the breast arising in microglandular adenosis. ( 7504394 )
1993
31
Immunohistochemical profile and differential diagnosis of microglandular adenosis. ( 8346180 )
1993
32
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. ( 8422116 )
1993
33
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. ( 8458288 )
1993
34
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. ( 1710101 )
1991
35
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
36
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. ( 3706610 )
1986
37
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. ( 6852780 )
1983
38
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. ( 6859388 )
1983
39
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. ( 6660348 )
1983

Variations for Microglandular Adenosis

Expression for Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for Microglandular Adenosis

GO Terms for Microglandular Adenosis

Cellular components related to Microglandular Adenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 ERBB2 ESR1 KRT18 PGR PIP S100B

Biological processes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 ERBB2 S100B TP53
2 steroid hormone mediated signaling pathway GO:0043401 8.96 ESR1 PGR
3 positive regulation of gene expression GO:0010628 8.8 ERBB2 PIP TP53

Molecular functions related to Microglandular Adenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.54 ESR1 PGR TP53
2 steroid hormone receptor activity GO:0003707 9.32 ESR1 PGR
3 core promoter sequence-specific DNA binding GO:0001046 9.26 ESR1 TP53
4 identical protein binding GO:0042802 9.26 ERBB2 ESR1 S100B TP53
5 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 ESR1 PGR
6 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Microglandular Adenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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