MCID: MCR019
MIFTS: 46

Microglandular Adenosis malady

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Summaries for Microglandular Adenosis

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33MalaCards
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MalaCards: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and adenoid cystic carcinoma. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and LKB1 signaling events. The compounds gold and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Microglandular Adenosis

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8Disease Ontology, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT
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Aliases & Descriptions:

microglandular adenosis 8
adenosis of the breast 8
adenosis of breast 62
adenosis - breast 8


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Disease Ontology8 DOID:5998
MeSH35 D005348
SNOMED-CT58 270893004
NCIt40 C3484

Related Diseases for Microglandular Adenosis

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17GeneCards, 18GeneDecks
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Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4MUC1, S100A1, KRT18, CTSD
2adenoid cystic carcinoma30.4ERBB2, KIT, S100A1, MUC1
3tubular adenocarcinoma30.3PGR, ESR1, MUC1, ERBB2, CTSD
4adenocarcinoma30.0PIP, PGR, ESR1, MUC1, ERBB2, KRT18
5breast cancer30.0PIP, PGR, ESR1, MUC1, KIT, ERBB2
6microglandular adenosis of breast10.5
7sinusitis10.4
8fibrosclerosis of breast10.4
9breast adenomyoepithelial adenosis10.3
10adenoiditis10.3
11apocrine adenosis of breast10.2
12blunt duct adenosis of breast10.2
13elephantiasis10.2
14sclerosing adenosis of breast10.1
15syringocystadenoma papilliferum10.1PIP
16nephrogenic adenoma10.1S100A1
17rosai-dorfman disease10.1CTSD
18glomus tumor10.1S100A1
19cystadenocarcinoma10.1MUC1
20secretory meningioma10.1MUC1
21perineurioma10.1MUC1
22cerebral meningioma10.1PGR
23hidradenoma10.1MUC1, PIP
24breast cyst10.1PIP, CTSD
25syringoma10.1MUC1, S100A1
26kidney cancer10.1EGFR
27hemangiopericytoma10.1MUC1, S100A1
28malignant fibroxanthoma10.1MUC1, S100A1
29spindle cell carcinoma10.1MUC1, PGR
30sertoli-leydig cell tumor10.1PGR, MUC1
31angiosarcoma10.1MUC1, KRT18
32sertoli cell tumor10.1PGR, MUC1
33merkel cell carcinoma10.1MUC1, KIT
34reticulosarcoma10.1MUC1, CTSD
35phyllode tumor10.1PGR, KIT
36breast fibroadenoma10.1ESR1, PGR
37uterine sarcoma10.1ESR1, KIT
38adenosarcoma10.1PGR, ESR1
39sex cord-gonadal stromal tumor10.0PGR, MUC1
40meningioma10.0ESR1, PGR
41progesterone resistance10.0PGR, ESR1
42bilateral breast cancer10.0PGR, ESR1
43chordoma10.0MUC1, S100A1, KRT18
44uterine carcinosarcoma10.0KIT, ERBB2
45leiomyomatosis10.0PGR, ESR1
46myoma10.0ESR1, PGR
47paraganglioma10.0S100A1, KIT
48uterine fibroid10.0PGR, ESR1
49lymphangioleiomyomatosis10.0PGR, ESR1
50dermatofibrosarcoma protuberans10.0MUC1, S100A1, KIT

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Symptoms for Microglandular Adenosis

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Drugs & Therapeutics for Microglandular Adenosis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Microglandular Adenosis

Search NIH Clinical Center for Microglandular Adenosis

Genetic Tests for Microglandular Adenosis

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Anatomical Context for Microglandular Adenosis

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33MalaCards
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MalaCards organs/tissues related to Microglandular Adenosis:

33
Breast

Animal Models for Microglandular Adenosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Microglandular Adenosis:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, MUC1, KIT, KRT18, EGFR
2MP:00053718.4PGR, ESR1, KIT, ERBB2, EGFR
3MP:00030128.4PGR, ESR1, MUC1, KIT, EGFR
4MP:00028738.1PGR, MUC1, S100A1, KIT, ERBB2, EGFR
5MP:00020068.1PGR, ESR1, MUC1, KIT, ERBB2, EGFR
6MP:00053808.1PGR, ESR1, KIT, ERBB2, KRT18, EGFR
7MP:00107718.0PGR, ESR1, MUC1, KIT, ERBB2, EGFR
8MP:00053787.9CTSD, EGFR, KRT18, ERBB2, KIT, ESR1
9MP:00053697.9PGR, ESR1, S100A1, KIT, ERBB2, EGFR
10MP:00053907.8PGR, ESR1, KIT, ERBB2, EGFR
11MP:00053867.8PGR, ESR1, S100A1, KIT, ERBB2, CTSD
12MP:00053767.6PGR, ESR1, MUC1, KIT, ERBB2, EGFR
13MP:00107687.6PGR, ESR1, KIT, ERBB2, KRT18, EGFR
14MP:00053897.5PIP, PGR, ESR1, KIT, ERBB2, EGFR
15MP:00053977.5PIP, PGR, ESR1, KIT, EGFR, CTSD
16MP:00053817.4PIP, ESR1, MUC1, KIT, ERBB2, EGFR
17MP:00053877.3PIP, PGR, ESR1, KIT, EGFR, CTSD
18MP:00053847.2PIP, PGR, ESR1, KIT, ERBB2, EGFR
19MP:00053857.1PIP, PGR, ESR1, S100A1, KIT, ERBB2
20MP:00053797.0CTSD, PIP, PGR, ESR1, MUC1, KIT

Publications for Microglandular Adenosis

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52PubMed
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Articles related to Microglandular Adenosis:

(show all 30)
idTitleAuthorsYear
1
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? (23584829)
2013
2
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
3
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
4
Microglandular adenosis. (21847399)
2011
5
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
6
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
7
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
8
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
9
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
10
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
11
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
12
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
13
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
14
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. (12883237)
2003
15
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
16
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
17
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
18
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
19
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
20
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
21
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
22
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
23
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
24
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993
25
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
26
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
27
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
28
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
29
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
30
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Variations for Microglandular Adenosis

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Expression for genes affiliated with Microglandular Adenosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

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50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 60Thomson Reuters, 57SinoBiological, 30KEGG, 5Cell Signaling Technology
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Pathways related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6EGFR, KIT
29.6ESR1, CTSD
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5EGFR, ERBB2
69.5EGFR, ERBB2
7
Show member pathways
9.4ESR1, PGR
8
Show member pathways
Nuclear Receptors38
9.4ESR1, PGR
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.3ESR1, EGFR
10
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.2EGFR, ERBB2, MUC1
119.2EGFR, ERBB2, MUC1
12
Show member pathways
Signal transduction PTEN pathway60
9.1EGFR, ERBB2, KIT
13
Show member pathways
9.1EGFR, ERBB2, KIT
149.1EGFR, ERBB2, KIT
159.1KIT, ERBB2, EGFR
16
Show member pathways
9.1KIT, ERBB2, EGFR
17
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.1ESR1, ERBB2, CTSD
188.9EGFR, ERBB2, ESR1
19
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.9ESR1, ERBB2, EGFR
208.9ESR1, ERBB2, EGFR
21
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
8.9ESR1, ERBB2, EGFR
22
Show member pathways
8.8KIT, ERBB2, EGFR, CTSD
23
Show member pathways
8.5EGFR, ERBB2, KIT, ESR1
24
Show member pathways
8.5ESR1, KIT, ERBB2, EGFR
25
Show member pathways
8.3EGFR, ERBB2, KIT, PIP
26
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
27
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
28
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
29
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
30
Show member pathways
7.0EGFR, KRT18, ERBB2, KIT, MUC1, ESR1

Compounds for genes affiliated with Microglandular Adenosis

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1gold459.4CTSD, KIT, KRT18, MUC1
2sunitinib45 51 1111.3ERBB2, KIT, EGFR
3alkylating agents519.3ESR1, EGFR
4p002459.3KRT18, KIT, ERBB2, CTSD
5megestrol acetate459.3PGR, ESR1, ERBB2
6hematoxylin459.3KIT, KRT18, MUC1, S100A1
7adriamycin459.2ERBB2, MUC1, PGR, CTSD
8toremifene45 1110.2ERBB2, PGR, ESR1
9dmso459.2KRT18, MUC1, PGR, CTSD
10ici 164384459.1ESR1, PGR
11estrone sulfate45 2410.1PGR, CTSD, ESR1
12capecitabine45 51 1111.1ERBB2, EGFR, PGR, KIT
13mucicarmine459.1PIP, MUC1, S100A1
14formaldehyde45 2410.0MUC1, KIT, ERBB2, KRT18, CTSD
15steroidal459.0CTSD, ESR1, PGR
16b 723458.9S100A1, PIP, MUC1
17everolimus45 51 1110.9EGFR, ESR1, ERBB2, KIT
18exemestane45 51 61 1111.9EGFR, ESR1, PGR, ERBB2
19anastrozole45 51 1110.9PGR, ESR1, EGFR, ERBB2
20lapatinib45 51 1110.9ERBB2, EGFR, PGR, ESR1
21taxane458.8ERBB2, PGR, EGFR, ESR1
22letrozole45 51 61 1111.8EGFR, PGR, ESR1, ERBB2
23gefitinib45 51 1110.8ERBB2, KIT, ESR1, EGFR
24aspartate458.8CTSD, KRT18, ERBB2, KIT, PGR
25cyclophosphamide45 51 1110.7KRT18, ERBB2, ESR1, PGR, CTSD
26methotrexate51 45 1110.6PGR, ESR1, MUC1, KIT, ERBB2
27fulvestrant45 51 29 1111.6ERBB2, KRT18, EGFR, ESR1, PGR
284-hydroxytamoxifen458.6CTSD, EGFR, ESR1, PGR, ERBB2
29bicalutamide45 61 1110.6PIP, EGFR, ESR1
30agar458.5CTSD, MUC1, EGFR, KRT18, ERBB2, PGR
31dihydrotestosterone45 29 24 1111.5MUC1, PIP, ESR1, PGR
32geldanamycin45 51 61 1111.5KIT, PGR, ERBB2, EGFR, ESR1
33genistein45 29 61 3 24 1113.5PGR, EGFR, ERBB2, ESR1, CTSD
34cisplatin45 51 61 1111.4ESR1, CTSD, EGFR, ERBB2, MUC1
35estradiol45 24 1110.3MUC1, CTSD, PIP, ESR1, PGR
36progestin458.3ESR1, MUC1, CTSD, ERBB2, EGFR, PGR
37docetaxel45 51 61 1111.2KRT18, ESR1, PGR, KIT, EGFR, ERBB2
38paclitaxel45 51 1110.2EGFR, ERBB2, KIT, CTSD, ESR1, PGR
39cycloheximide458.1PGR, ERBB2, ESR1, EGFR, KIT, CTSD
40doxorubicin45 51 119.9ESR1, PGR, KRT18, EGFR, KIT, CTSD
41trastuzumab45 51 119.9CTSD, EGFR, ERBB2, KIT, MUC1, ESR1
425fluorouracil457.6CTSD, EGFR, KRT18, ERBB2, KIT, MUC1
43steroid457.6PGR, KRT18, CTSD, PIP, ESR1, ERBB2
44vegf457.5MUC1, ESR1, PGR, CTSD, ERBB2, KRT18
45retinoic acid45 248.5KRT18, MUC1, CTSD, EGFR, KIT, PGR
46tamoxifen45 51 29 1110.4PIP, CTSD, EGFR, ERBB2, PGR, ESR1
47testosterone45 61 24 119.7CTSD, EGFR, KRT18, ERBB2, MUC1, PGR
48progesterone45 29 61 24 1110.2KIT, ERBB2, KRT18, EGFR, CTSD, MUC1
49paraffin456.2PIP, PGR, ESR1, MUC1, S100A1, KIT
50estrogen456.2S100A1, ESR1, PGR, KIT, ERBB2, KRT18

GO Terms for genes affiliated with Microglandular Adenosis

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16Gene Ontology
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Cellular components related to Microglandular Adenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CTSD, EGFR, KIT, PIP
2apical plasma membraneGO:0163248.0EGFR, ERBB2, MUC1, PIP

Biological processes related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.7KIT, ESR1
2signal transduction by phosphorylationGO:0230149.7ERBB2, KIT
3cellular response to estradiol stimulusGO:0713929.5EGFR, ESR1
4positive regulation of MAP kinase activityGO:0434069.5EGFR, ERBB2
5peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, ERBB2, KIT
6phosphatidylinositol-mediated signalingGO:0480159.4EGFR, ERBB2, KIT
7protein autophosphorylationGO:0467779.3KIT, ERBB2, EGFR
8positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, EGFR
9fibroblast growth factor receptor signaling pathwayGO:0085439.3KIT, ERBB2, EGFR
10Fc-epsilon receptor signaling pathwayGO:0380959.3EGFR, ERBB2, KIT
11epidermal growth factor receptor signaling pathwayGO:0071739.2KIT, ERBB2, EGFR
12positive regulation of fibroblast proliferationGO:0481469.0EGFR, ESR1
13neurotrophin TRK receptor signaling pathwayGO:0480119.0EGFR, ERBB2, KIT
14signal transductionGO:0071658.3PGR, ESR1, KIT, ERBB2, EGFR

Molecular functions related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:0302359.5EGFR, ESR1
3steroid bindingGO:0054969.4PGR, ESR1
4steroid hormone receptor activityGO:0037079.4ESR1, PGR
5aspartic-type endopeptidase activityGO:0041909.4CTSD, PIP
6receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2, KIT
7transmembrane receptor protein tyrosine kinase activityGO:0047149.4KIT, ERBB2, EGFR
8protein tyrosine kinase activityGO:0047139.3KIT, ERBB2, EGFR
9glycoprotein bindingGO:0019488.8EGFR, PIP
10enzyme bindingGO:0198998.8EGFR, ESR1, PGR
11identical protein bindingGO:0428028.5ESR1, S100A1, ERBB2, EGFR
12protein bindingGO:0055156.8PGR, ESR1, MUC1, S100A1, KIT, ERBB2

Products for genes affiliated with Microglandular Adenosis

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Sources for Microglandular Adenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet