MCID: MCR019
MIFTS: 39

Microglandular Adenosis malady

Summaries for Microglandular Adenosis

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33MalaCards
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MalaCards: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and adenoid cystic carcinoma. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Nanog in Mammalian ESC Pluripotency and SHC1 events in ERBB2 signaling. The compounds ici 164384 and Ethynodiol Diacetate have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Microglandular Adenosis

Sources:
8Disease Ontology, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

microglandular adenosis 8
adenosis of the breast 8
adenosis of breast 61
adenosis - breast 8


External Ids:

Disease Ontology8 DOID:5998
MeSH35 D005348
SNOMED-CT57 270893004
NCIt40 C3484

Related Diseases for Microglandular Adenosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.3CTSD, S100A1, MUC1, KRT18
2adenoid cystic carcinoma30.3KIT, S100A1, MUC1, ERBB2
3tubular adenocarcinoma30.3CTSD, MUC1, PGR, ERBB2, ESR1
4adenocarcinoma30.3MUC1, ESR1, ERBB2, KRT18, PGR, CTSD
5microglandular adenosis of breast10.5
6sinusitis10.4
7invasive mole10.4
8fibrosclerosis of breast10.4
9breast adenomyoepithelial adenosis10.3
10acinic cell breast carcinoma10.2
11breast apocrine carcinoma10.2
12breast adenoid cystic carcinoma10.2
13breast adenocarcinoma10.2
14apocrine adenosis of breast10.2
15blunt duct adenosis of breast10.2
16sclerosing adenosis of breast10.1
17gastritis10.0KRT18
18azoospermia10.0KRT18
19desmoid tumor10.0KIT
20hepatocellular carcinoma10.0KRT18
21germ cell tumors10.0KIT
22syringocystadenoma papilliferum10.0PIP
23liver cirrhosis10.0KRT18
24rosai-dorfman disease10.0CTSD
25hemangioblastoma10.0MUC1
26cystadenocarcinoma10.0MUC1
27rhabdomyosarcoma10.0S100A1
28rhabdoid tumor10.0MUC1
29secretory meningioma10.0MUC1
30cerebral meningioma10.0PGR
31interstitial lung disease10.0MUC1
32renal oncocytoma10.0S100A1
33astrocytoma10.0EGFR
34acute leukemia10.0KIT
35cholesteatoma10.0S100A1
36hidradenoma10.0PIP, MUC1
37nephrogenic adenoma10.0S100A1
38medulloblastoma10.0ERBB2
39esophageal cancer10.0EGFR
40perineurioma10.0MUC1
41angiosarcoma10.0MUC1, KRT18
42anaplastic astrocytoma10.0EGFR
43breast cyst10.0PIP, CTSD
44oral cancer10.0EGFR
45osteosarcoma10.0ESR1
46myoepithelioma10.0S100A1
47uterine carcinosarcoma10.0ERBB2, KIT
48oligodendroglioma10.0EGFR
49glomus tumor10.0S100A1
50gastrointestinal stromal tumor10.0KIT, S100A1

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Clinical Features for Microglandular Adenosis

Drugs & Therapeutics for Microglandular Adenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Microglandular Adenosis

Drug clinical trials:

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Search NIH Clinical Center for Microglandular Adenosis

Search CenterWatch for Microglandular Adenosis

Genetic Tests for Microglandular Adenosis

Anatomical Context for Microglandular Adenosis

Animal Models for Microglandular Adenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Microglandular Adenosis

Sources:
51PubMed
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Articles related to Microglandular Adenosis:

(show all 31)
idTitleAuthorsYear
1
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? (23584829)
2013
2
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
3
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
4
Microglandular adenosis. (21847399)
2011
5
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
6
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
7
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
8
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
9
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
10
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
11
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
12
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
13
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
14
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. (12883237)
2003
15
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
16
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
17
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
18
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
19
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
20
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
21
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
22
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
23
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
24
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. (8458288)
1993
25
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993
26
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
27
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
28
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
29
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
30
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
31
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Genetic Variations for Microglandular Adenosis

Expression for genes affiliated with Microglandular Adenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 56SinoBiological
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Pathways related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7KIT, EGFR
2
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9.6ERBB2, EGFR
3
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9.3EGFR, ERBB2, KIT
4
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9.3EGFR, KIT, ERBB2
59.3EGFR, KIT, ERBB2
6
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9.3EGFR, KIT, ERBB2
79.3EGFR, MUC1, ERBB2
8
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9.3EGFR, MUC1, ERBB2
9
Development Prolactin receptor signaling
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9.3ERBB2, ESR1, CTSD
109.1ESR1, ERBB2, EGFR
11
Development Ligand-independent activation of ESR1 and ESR2
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9.1ESR1, ERBB2, EGFR
12
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8.7PIP, EGFR, ERBB2, KIT
13
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8.7ERBB2, EGFR, KIT, PIP
14
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8.6ESR1, KRT18, PIP, ERBB2
15
Hide members
8.4ERBB2, ESR1, KIT, PGR, EGFR

Compounds for genes affiliated with Microglandular Adenosis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1ici 164384459.8ESR1, PGR
2Ethynodiol Diacetate119.8PGR, ESR1
3hematoxylin459.7S100A1, KIT, KRT18
4everolimus50 45 1111.6EGFR, KIT, ERBB2
5sunitinib45 50 1111.6ERBB2, KIT, EGFR
6Allylestrenol119.6ESR1, PGR
7megestrol acetate459.5ERBB2, ESR1, PGR
8gold459.5CTSD, MUC1, KIT, KRT18
9toremifene45 1110.5PGR, ERBB2, ESR1
10idoxifene459.5PGR, ESR1
11p002459.5KIT, ERBB2, KRT18, CTSD
12steroidal459.4CTSD, ESR1, PGR
13estrone sulfate45 2410.4PGR, CTSD, ESR1
14adriamycin459.4CTSD, ERBB2, PGR, MUC1
15capecitabine45 50 1111.3ERBB2, EGFR, PGR, KIT
16mucicarmine459.3S100A1, PIP, MUC1
17Etonogestrel119.3ESR1, PGR
18b 723459.2MUC1, S100A1, PIP
19dihydrotestosterone45 29 11 2412.2ESR1, PGR, PIP
20formaldehyde45 2410.2MUC1, KIT, KRT18, ERBB2, CTSD
21dmso459.2PGR, CTSD, KRT18, MUC1
22anastrozole45 1110.1PGR, ESR1, ERBB2, EGFR
23exemestane50 45 60 1112.1EGFR, ESR1, ERBB2, PGR
24gefitinib45 50 1111.1ERBB2, KIT, ESR1, EGFR
25lapatinib45 50 1111.1ESR1, ERBB2, PGR, EGFR
26taxane459.1EGFR, PGR, ERBB2, ESR1
27letrozole45 50 60 1112.1EGFR, PGR, ERBB2, ESR1
28bicalutamide45 60 1111.1PIP, ESR1, EGFR
29cyclophosphamide45 50 1111.0ERBB2, ESR1, KRT18, PGR, CTSD
30methotrexate45 50 1110.9PGR, MUC1, ESR1, ERBB2, KIT
31fulvestrant45 50 29 1111.9EGFR, ESR1, KRT18, PGR, ERBB2
32aspartate458.9CTSD, PGR, KIT, KRT18, ERBB2
334-hydroxytamoxifen458.8ESR1, PGR, CTSD, ERBB2, EGFR
34paclitaxel45 50 1110.8ESR1, ERBB2, PGR, EGFR, CTSD
35geldanamycin45 50 60 1111.8PGR, ERBB2, KIT, EGFR, ESR1
36steroid458.7PIP, ESR1, ERBB2, KRT18, CTSD
37agar458.7PGR, ERBB2, KRT18, MUC1, CTSD, EGFR
38genistein45 29 60 2 11 2413.7EGFR, ERBB2, CTSD, ESR1, PGR
39estradiol45 11 2410.6ESR1, PGR, MUC1, PIP, CTSD
40docetaxel45 50 60 1111.5ERBB2, KRT18, ESR1, EGFR, KIT, PGR
41progestin458.5MUC1, EGFR, ESR1, ERBB2, PGR, CTSD
42doxorubicin45 50 1110.2CTSD, EGFR, PGR, KIT, KRT18, ERBB2
43trastuzumab45 50 1110.2ERBB2, CTSD, EGFR, MUC1, KIT, ESR1
445fluorouracil457.9EGFR, ESR1, ERBB2, KRT18, KIT, PGR
45tamoxifen45 50 29 1110.9CTSD, PIP, EGFR, PGR, ERBB2, MUC1
46vegf457.9KIT, KRT18, ERBB2, ESR1, EGFR, CTSD
47retinoic acid45 248.8KRT18, KIT, CTSD, PGR, MUC1, EGFR
48testosterone45 60 11 2410.3KRT18, ERBB2, PGR, ESR1, MUC1, EGFR
49paraffin456.8PIP, CTSD, EGFR, MUC1, PGR, KIT
50progesterone45 60 29 11 2410.8KRT18, S100A1, PIP, EGFR, MUC1, PGR

GO Terms for genes affiliated with Microglandular Adenosis

Sources:
16Gene Ontology
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Biological processes related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:0230149.9ERBB2, KIT
2positive regulation of phospholipase C activityGO:0108639.8ESR1, KIT
3cellular response to estradiol stimulusGO:0713929.6EGFR, ESR1
4phosphatidylinositol-mediated signalingGO:0480159.4EGFR, KIT, ERBB2
5protein autophosphorylationGO:0467779.3ERBB2, KIT, EGFR
6epidermal growth factor receptor signaling pathwayGO:0071739.3ERBB2, KIT, EGFR
7fibroblast growth factor receptor signaling pathwayGO:0085439.2EGFR, KIT, ERBB2
8Fc-epsilon receptor signaling pathwayGO:0380959.0ERBB2, KIT, EGFR
9signal transductionGO:0071658.5EGFR, PGR, KIT, ERBB2, ESR1

Molecular functions related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7ERBB2, EGFR
2steroid bindingGO:0054969.6ESR1, PGR
3nitric-oxide synthase regulator activityGO:0302359.6EGFR, ESR1
4receptor signaling protein tyrosine kinase activityGO:0047169.5ERBB2, KIT, EGFR
5transmembrane receptor protein tyrosine kinase activityGO:0047149.4ERBB2, KIT, EGFR
6protein tyrosine kinase activityGO:0047139.3ERBB2, KIT, EGFR
7identical protein bindingGO:0428028.3S100A1, EGFR, ERBB2, ESR1
8protein bindingGO:0055156.8S100A1, CTSD, EGFR, MUC1, PGR, KIT

Products for genes affiliated with Microglandular Adenosis

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Sources for Microglandular Adenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet