Aliases & Classifications for Microglandular Adenosis

MalaCards integrated aliases for Microglandular Adenosis:

Name: Microglandular Adenosis 12 14
Fibrocystic Breast Disease 41
Breast Fibrocystic Disease 69
Adenosis of the Breast 12
Adenosis of Breast 69
Adenosis - Breast 12

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Disease Ontology 12 DOID:5998
MeSH 41 D005348
NCIt 46 C3484
SNOMED-CT 64 270893004

Summaries for Microglandular Adenosis

MalaCards based summary : Microglandular Adenosis, also known as fibrocystic breast disease, is related to breast disease and tubular adenocarcinoma. An important gene associated with Microglandular Adenosis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Relaxin signaling pathway. The drugs Antibodies and Autoantibodies have been mentioned in the context of this disorder. Affiliated tissues include testes and breast, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Microglandular Adenosis

Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 breast disease 30.6 ERBB2 PGR TP53
2 tubular adenocarcinoma 29.7 EGFR ERBB2 PGR
3 adenocarcinoma 29.4 EGFR ERBB2 TP53
4 breast cancer 27.8 EGFR ERBB2 KRT18 PGR PIP TP53
5 microglandular adenosis of breast 12.2
6 apocrine adenosis of breast 11.5
7 fibrosclerosis of breast 11.2
8 breast adenomyoepithelial adenosis 11.0
9 sclerosing adenosis of breast 11.0
10 scirrhous adenocarcinoma 10.3 ERBB2 PGR
11 breast apocrine carcinoma 10.3 ERBB2 PGR
12 glassy cell carcinoma of the cervix 10.3 ERBB2 PGR
13 breast medullary carcinoma 10.3 ERBB2 PGR
14 progesterone-receptor positive breast cancer 10.3 ERBB2 PGR
15 apocrine adenocarcinoma 10.3 ERBB2 PGR
16 papillary ependymoma 10.3 KRT18 S100B
17 breast secretory carcinoma 10.3 ERBB2 PGR
18 gastric signet ring cell adenocarcinoma 10.3 PGR PIP
19 breast neuroendocrine neoplasm 10.3 ERBB2 PIP
20 papillary hidradenoma 10.2 PGR PIP
21 cervical clear cell adenocarcinoma 10.2 KRT18 PGR
22 bilateral breast cancer 10.2 ERBB2 PGR
23 breast papillary carcinoma 10.2 ERBB2 PGR
24 triple-receptor negative breast cancer 10.2 ERBB2 PGR
25 vulval paget's disease 10.2 ERBB2 PIP
26 malignant giant cell tumor 10.2 S100B TP53
27 intraneural perineurioma 10.2 KRT18 S100B
28 vulva adenocarcinoma 10.2 ERBB2 PIP
29 sinusitis 10.2
30 endometrium carcinoma in situ 10.2 PGR TP53
31 estrogen-receptor negative breast cancer 10.2 ERBB2 PGR
32 paget disease, extramammary 10.2 ERBB2 PIP
33 vestibular gland benign neoplasm 10.2 PGR TP53
34 bartholin's gland adenoma 10.2 PGR TP53
35 female reproductive endometrioid cancer 10.2 PGR TP53
36 breast malignant phyllodes tumor 10.2 PGR TP53
37 olfactory groove meningioma 10.2 PGR TP53
38 cutaneous adenocystic carcinoma 10.2 KRT18 PIP
39 bartholin's gland benign neoplasm 10.2 PGR TP53
40 spiradenoma 10.2 S100B TP53
41 cervical carcinosarcoma 10.2 PGR TP53
42 synchronous bilateral breast carcinoma 10.2 PGR TP53
43 breast fibroadenoma 10.2 ERBB2 PGR
44 papilloma of choroid plexus 10.2 S100B TP53
45 papillary serous adenocarcinoma 10.2 PGR TP53
46 anterior cranial fossa meningioma 10.2 PGR TP53
47 glycogen-rich clear cell breast carcinoma 10.2 PGR TP53
48 adenosarcoma 10.2 PGR TP53
49 uterine corpus serous adenocarcinoma 10.2 ERBB2 TP53
50 glioma susceptibility 1 10.2 ERBB2 TP53

Comorbidity relations with Microglandular Adenosis via Phenotypic Disease Network (PDN):


Breast Fibroadenosis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Hypothyroidism Mastitis

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to Microglandular Adenosis

Symptoms & Phenotypes for Microglandular Adenosis

GenomeRNAi Phenotypes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.13 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 9.13 EGFR
3 Increased cell death HMECs cells GR00103-A-0 9.02 EGFR KRT18 PGR PIP TP53

MGI Mouse Phenotypes related to Microglandular Adenosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.8 TP53 EGFR ERBB2 KRT18 PGR
2 endocrine/exocrine gland MP:0005379 9.77 TP53 EGFR ERBB2 PGR PIP
3 integument MP:0010771 9.72 TP53 EGFR ERBB2 PGR S100B
4 limbs/digits/tail MP:0005371 9.56 TP53 EGFR ERBB2 PGR
5 neoplasm MP:0002006 9.46 TP53 EGFR ERBB2 PGR
6 normal MP:0002873 9.35 TP53 EGFR ERBB2 PGR S100B
7 reproductive system MP:0005389 9.02 TP53 EGFR ERBB2 PGR PIP

Drugs & Therapeutics for Microglandular Adenosis

Drugs for Microglandular Adenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Autoantibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Unknown status NCT02066025

Search NIH Clinical Center for Microglandular Adenosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: fibrocystic breast disease

Genetic Tests for Microglandular Adenosis

Anatomical Context for Microglandular Adenosis

MalaCards organs/tissues related to Microglandular Adenosis:

38
Testes, Breast

Publications for Microglandular Adenosis

Articles related to Microglandular Adenosis:

(show all 42)
# Title Authors Year
1
Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases. ( 28372344 )
2017
2
Metaplastic Carcinoma With Extensive Chondromyxoid Differentiation Arising in Association With Microglandular Adenosis. ( 28381146 )
2017
3
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family. ( 27713419 )
2017
4
Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis. ( 28372347 )
2017
5
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations. ( 26806567 )
2016
6
Breast atypical microglandular adenosis can be a diagnostic pitfall on fine-needle aspiration samples. ( 26991047 )
2016
7
Atypical microglandular adenosis post-neoadjuvant chemotherapy. ( 27773126 )
2016
8
Microglandular adenosis: a prime suspect in triple-negative breast cancer development. ( 27061094 )
2016
9
Vulval Microglandular Adenosis-like Neoplasm With Chondromyxoid Stroma: Report of a Unique Case. ( 26535982 )
2015
10
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. ( 25337263 )
2014
11
Invasive breast carcinoma arising in microglandular adenosis: two case reports. ( 24454466 )
2013
12
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? ( 23584829 )
2013
13
Acinic cell carcinoma of the breast arising in microglandular adenosis. ( 24369519 )
2013
14
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. ( 22486256 )
2012
15
Microglandular adenosis with transition to breast carcinoma: a series of three cases. ( 21753716 )
2011
16
Microglandular adenosis. ( 21847399 )
2011
17
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. ( 20846267 )
2010
18
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. ( 20922408 )
2010
19
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. ( 19922592 )
2009
20
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. ( 19824997 )
2009
21
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. ( 19047897 )
2009
22
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. ( 18300793 )
2008
23
Breast carcinoma arising in microglandular adenosis: a review of the literature. ( 17824796 )
2007
24
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. ( 15129910 )
2004
25
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. ( 12883237 )
2003
26
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. ( 12521372 )
2003
27
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. ( 12042957 )
2002
28
[Mammary carcinoma arising in microglandular adenosis: a case report]. ( 11852363 )
2001
29
Carcinoma arising in microglandular adenosis of the breast. ( 12574855 )
2001
30
Microglandular adenosis arising in chronic paranasal sinusitis. ( 10841649 )
2000
31
Microglandular adenosis arising in a chronic paranasal sinusitis. ( 11150125 )
2000
32
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. ( 11494007 )
2000
33
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. ( 8422116 )
1993
34
Immunohistochemical profile and differential diagnosis of microglandular adenosis. ( 8346180 )
1993
35
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. ( 8458288 )
1993
36
Carcinoma of the breast arising in microglandular adenosis. ( 7504394 )
1993
37
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. ( 1710101 )
1991
38
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
39
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. ( 3706610 )
1986
40
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. ( 6859388 )
1983
41
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. ( 6660348 )
1983
42
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. ( 6852780 )
1983

Variations for Microglandular Adenosis

Expression for Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for Microglandular Adenosis

Pathways related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 EGFR ERBB2 TP53
2
Show member pathways
12.27 EGFR ERBB2 TP53
3
Show member pathways
12.22 EGFR ERBB2 PGR TP53
4 12.21 EGFR ERBB2 TP53
5
Show member pathways
12.17 EGFR ERBB2 TP53
6
Show member pathways
12.15 EGFR ERBB2 TP53
7
Show member pathways
12.11 EGFR ERBB2 TP53
8
Show member pathways
12.09 EGFR ERBB2 TP53
9
Show member pathways
11.91 EGFR ERBB2 TP53
10 11.89 EGFR ERBB2 TP53
11
Show member pathways
11.73 EGFR ERBB2 TP53
12
Show member pathways
11.59 EGFR ERBB2 TP53
13 11.35 EGFR ERBB2
14 11.29 EGFR TP53
15 11.22 EGFR ERBB2
16 11.2 EGFR ERBB2 TP53
17 11.01 EGFR TP53
18 10.97 EGFR ERBB2
19
Show member pathways
10.96 EGFR ERBB2 PGR S100B
20 10.94 EGFR ERBB2 TP53
21 10.93 EGFR ERBB2

GO Terms for Microglandular Adenosis

Cellular components related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 EGFR ERBB2 KRT18 PGR PIP S100B
2 perinuclear region of cytoplasm GO:0048471 8.92 EGFR ERBB2 KRT18 S100B

Biological processes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.49 EGFR ERBB2
2 learning or memory GO:0007611 9.48 EGFR S100B
3 signal transduction by protein phosphorylation GO:0023014 9.46 EGFR ERBB2
4 cellular response to epidermal growth factor stimulus GO:0071364 9.43 EGFR ERBB2
5 ERBB2 signaling pathway GO:0038128 9.4 EGFR ERBB2
6 cellular response to reactive oxygen species GO:0034614 9.37 EGFR TP53
7 regulation of cell motility GO:2000145 9.32 EGFR ERBB2
8 regulation of ERK1 and ERK2 cascade GO:0070372 9.26 EGFR ERBB2
9 cell proliferation GO:0008283 9.26 EGFR ERBB2 S100B TP53
10 negative regulation of ERBB signaling pathway GO:1901185 9.16 EGFR ERBB2
11 wound healing GO:0042060 8.8 EGFR ERBB2 TP53

Molecular functions related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 EGFR ERBB2 PGR S100B TP53
2 enzyme binding GO:0019899 9.5 EGFR PGR TP53
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 EGFR ERBB2
4 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 EGFR ERBB2
5 protein phosphatase binding GO:0019903 8.8 EGFR ERBB2 TP53

Sources for Microglandular Adenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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