Aliases & Classifications for Microglandular Adenosis

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Aliases & Descriptions for Microglandular Adenosis:

Name: Microglandular Adenosis 8
Adenosis of the Breast 8
 
Adenosis of Breast 61
Adenosis - Breast 8


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Disease Ontology8 DOID:5998
MeSH33 D005348
SNOMED-CT56 270893004
NCIt39 C3484

Summaries for Microglandular Adenosis

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MalaCards based summary: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and breast cancer. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and LKB1 signaling events. The compounds gold and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Related Diseases for Microglandular Adenosis

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Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4MUC1, S100A1, KRT18, CTSD
2breast cancer30.4ERBB2, ESR1, PGR
3tubular adenocarcinoma29.9PGR, ESR1, MUC1, ERBB2, CTSD
4adenocarcinoma28.9PIP, PGR, ESR1, MUC1, ERBB2, KRT18
5microglandular adenosis of breast10.6
6syringocystadenoma papilliferum10.5PIP
7nephrogenic adenoma10.5S100A1
8rosai-dorfman disease10.5CTSD
9glomus tumor10.5S100A1
10cystadenocarcinoma10.5MUC1
11secretory meningioma10.5MUC1
12sinusitis10.4
13perineurioma10.4MUC1
14cerebral meningioma10.4PGR
15fibrosclerosis of breast10.4
16hidradenoma10.4MUC1, PIP
17breast cyst10.4PIP, CTSD
18syringoma10.4MUC1, S100A1
19renal cell carcinoma10.3EGFR
20hemangiopericytoma10.3MUC1, S100A1
21breast adenomyoepithelial adenosis10.3
22adenoiditis10.3
23malignant fibroxanthoma10.3MUC1, S100A1
24spindle cell carcinoma10.2MUC1, PGR
25sertoli-leydig cell tumor10.2PGR, MUC1
26apocrine adenosis of breast10.2
27blunt duct adenosis of breast10.2
28elephantiasis10.2
29angiosarcoma10.2MUC1, KRT18
30sertoli cell tumor10.2PGR, MUC1
31merkel cell carcinoma10.2MUC1, KIT
32reticulosarcoma10.2MUC1, CTSD
33benign breast phyllodes tumor10.2PGR, KIT
34breast fibroadenoma10.2ESR1, PGR
35uterine sarcoma10.2ESR1, KIT
36adenosarcoma10.2PGR, ESR1
37sex cord-gonadal stromal tumor10.2PGR, MUC1
38meningioma, familial10.2ESR1, PGR
39progesterone resistance10.2PGR, ESR1
40bilateral breast cancer10.2PGR, ESR1
41chordoma10.2MUC1, S100A1, KRT18
42uterine carcinosarcoma10.2KIT, ERBB2
43leiomyomatosis10.2PGR, ESR1
44myoma10.2ESR1, PGR
45paraganglioma10.2S100A1, KIT
46uterine fibroid10.2PGR, ESR1
47lymphangioleiomyomatosis10.2PGR, ESR1
48dermatofibrosarcoma protuberans10.2MUC1, S100A1, KIT
49malignant peripheral nerve sheath tumor10.2MUC1, S100A1, KIT
50gastrointestinal stromal tumor10.1S100A1, KIT

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Symptoms for Microglandular Adenosis

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Drugs & Therapeutics for Microglandular Adenosis

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Drug clinical trials:

Search ClinicalTrials for Microglandular Adenosis

Search NIH Clinical Center for Microglandular Adenosis

Genetic Tests for Microglandular Adenosis

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Anatomical Context for Microglandular Adenosis

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MalaCards organs/tissues related to Microglandular Adenosis:

31
Breast

Animal Models for Microglandular Adenosis or affiliated genes

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MGI Mouse Phenotypes related to Microglandular Adenosis:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, MUC1, KIT, KRT18, EGFR
2MP:00053718.4PGR, ERBB2, KIT, ESR1, EGFR
3MP:00030128.4EGFR, MUC1, PGR, KIT, ESR1
4MP:00028738.1EGFR, ERBB2, KIT, S100A1, PGR, MUC1
5MP:00020068.1ESR1, MUC1, KIT, ERBB2, EGFR, PGR
6MP:00053808.1KRT18, ERBB2, KIT, PGR, ESR1, EGFR
7MP:00107718.0MUC1, KIT, ERBB2, EGFR, PGR, ESR1
8MP:00053787.9CTSD, EGFR, KRT18, ERBB2, KIT, ESR1
9MP:00053697.9ESR1, S100A1, ERBB2, EGFR, PGR, KIT
10MP:00053907.8ESR1, ERBB2, KIT, EGFR, PGR
11MP:00053867.8CTSD, ERBB2, KIT, S100A1, ESR1, PGR
12MP:00053767.6EGFR, ESR1, MUC1, KIT, ERBB2, CTSD
13MP:00107687.6EGFR, CTSD, KIT, KRT18, ERBB2, ESR1
14MP:00053977.5PGR, ESR1, KIT, EGFR, CTSD, PIP
15MP:00053897.5EGFR, ESR1, PIP, PGR, KIT, ERBB2
16MP:00053817.4KIT, ERBB2, MUC1, PIP, CTSD, EGFR
17MP:00053877.3ESR1, PIP, PGR, KIT, EGFR, CTSD
18MP:00053847.2PGR, ESR1, PIP, KIT, ERBB2, CTSD
19MP:00053857.1EGFR, ERBB2, KIT, S100A1, PIP, PGR
20MP:00053797.0EGFR, CTSD, ERBB2, KIT, MUC1, ESR1

Publications for Microglandular Adenosis

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Articles related to Microglandular Adenosis:

(show all 32)
idTitleAuthorsYear
1
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. (25337263)
2014
2
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? (23584829)
2013
3
Invasive breast carcinoma arising in microglandular adenosis: two case reports. (24454466)
2013
4
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
5
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
6
Microglandular adenosis. (21847399)
2011
7
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
8
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
9
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
10
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
11
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
12
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
13
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
14
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
15
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
16
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. (12883237)
2003
17
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
18
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
19
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
20
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
21
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
22
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
23
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
24
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
25
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
26
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. (8458288)
1993
27
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
28
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
29
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
30
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
31
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
32
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Variations for Microglandular Adenosis

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Expression for genes affiliated with Microglandular Adenosis

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Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

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Pathways related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KIT, EGFR
29.6CTSD, ESR1
39.5EGFR, ERBB2
4
Show member pathways
9.5ERBB2, EGFR
59.5ERBB2, EGFR
69.5ERBB2, EGFR
7
Show member pathways
9.4PGR, ESR1
8
Show member pathways
Nuclear Receptors36
9.4PGR, ESR1
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway59
9.3EGFR, ESR1
10
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.2EGFR, MUC1, ERBB2
119.2MUC1, ERBB2, EGFR
12
Show member pathways
Signal transduction PTEN pathway59
9.1ERBB2, EGFR, KIT
13
Show member pathways
9.1EGFR, KIT, ERBB2
14
Show member pathways
9.1ERBB2, KIT, EGFR
159.1ERBB2, EGFR, KIT
169.1EGFR, ERBB2, KIT
17
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
9.1ERBB2, CTSD, ESR1
188.9EGFR, ERBB2, ESR1
19
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.9ERBB2, EGFR, ESR1
208.9ESR1, ERBB2, EGFR
21
Show member pathways
Development Ligand independent activation of ESR1 and ESR259
8.9EGFR, ESR1, ERBB2
22
Show member pathways
8.8KIT, CTSD, EGFR, ERBB2
23
Show member pathways
8.5EGFR, KIT, ERBB2, ESR1
24
Show member pathways
8.5EGFR, ESR1, KIT, ERBB2
25
Show member pathways
8.3EGFR, ERBB2, KIT, PIP
26
Show member pathways
8.3ERBB2, EGFR, KIT, PIP
27
Show member pathways
8.3ERBB2, KIT, PIP, EGFR
28
Show member pathways
8.1ERBB2, EGFR, KIT, ESR1, PGR
29
Show member pathways
8.1ESR1, KIT, PGR, ERBB2, EGFR
30
Show member pathways
7.0KIT, PIP, ESR1, MUC1, ERBB2, KRT18

Compounds for genes affiliated with Microglandular Adenosis

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Compounds related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1gold449.4CTSD, KIT, KRT18, MUC1
2sunitinib44 50 1111.3ERBB2, KIT, EGFR
3alkylating agents509.3ESR1, EGFR
4p002449.3KRT18, KIT, ERBB2, CTSD
5megestrol acetate449.3PGR, ESR1, ERBB2
6hematoxylin449.3KIT, KRT18, MUC1, S100A1
7adriamycin449.2ERBB2, MUC1, PGR, CTSD
8toremifene44 1110.2ERBB2, PGR, ESR1
9dmso449.2KRT18, MUC1, PGR, CTSD
10ici 164384449.1ESR1, PGR
11estrone sulfate44 2410.1PGR, CTSD, ESR1
12capecitabine44 50 1111.1ERBB2, EGFR, PGR, KIT
13mucicarmine449.1PIP, MUC1, S100A1
14formaldehyde44 2410.0MUC1, KIT, ERBB2, KRT18, CTSD
15steroidal449.0CTSD, ESR1, PGR
16b 723448.9S100A1, PIP, MUC1
17everolimus44 50 1110.9EGFR, ESR1, ERBB2, KIT
18exemestane44 50 60 1111.9EGFR, ESR1, PGR, ERBB2
19anastrozole44 50 1110.9PGR, ESR1, EGFR, ERBB2
20lapatinib44 50 1110.9ERBB2, EGFR, PGR, ESR1
21taxane448.8ERBB2, PGR, EGFR, ESR1
22letrozole44 50 60 1111.8EGFR, PGR, ESR1, ERBB2
23gefitinib44 50 1110.8ERBB2, KIT, ESR1, EGFR
24aspartate448.8CTSD, KRT18, ERBB2, KIT, PGR
25cyclophosphamide44 50 1110.7KRT18, ERBB2, ESR1, PGR, CTSD
26methotrexate50 44 1110.6PGR, ESR1, MUC1, KIT, ERBB2
27fulvestrant44 50 28 1111.6ERBB2, KRT18, EGFR, ESR1, PGR
284-hydroxytamoxifen448.6CTSD, EGFR, ESR1, PGR, ERBB2
29bicalutamide44 60 1110.6PIP, EGFR, ESR1
30agar448.5CTSD, MUC1, EGFR, KRT18, ERBB2, PGR
31dihydrotestosterone44 28 24 1111.5MUC1, PIP, ESR1, PGR
32geldanamycin44 50 60 1111.5KIT, PGR, ERBB2, EGFR, ESR1
33genistein44 28 60 1 24 1113.5PGR, EGFR, ERBB2, ESR1, CTSD
34cisplatin44 50 60 1111.4ESR1, CTSD, EGFR, ERBB2, MUC1
35estradiol44 24 1110.3MUC1, CTSD, PIP, ESR1, PGR
36progestin448.3ESR1, MUC1, CTSD, ERBB2, EGFR, PGR
37docetaxel44 50 60 1111.2KRT18, ESR1, PGR, KIT, EGFR, ERBB2
38paclitaxel44 50 1110.2EGFR, ERBB2, KIT, CTSD, ESR1, PGR
39cycloheximide448.1PGR, ERBB2, ESR1, EGFR, KIT, CTSD
40doxorubicin44 50 119.9ESR1, PGR, KRT18, EGFR, KIT, CTSD
41trastuzumab44 50 119.9CTSD, EGFR, ERBB2, KIT, MUC1, ESR1
425fluorouracil447.6CTSD, EGFR, KRT18, ERBB2, KIT, MUC1
43steroid447.6PGR, KRT18, CTSD, PIP, ESR1, ERBB2
44vegf447.5MUC1, ESR1, PGR, CTSD, ERBB2, KRT18
45retinoic acid44 248.5KRT18, MUC1, CTSD, EGFR, KIT, PGR
46tamoxifen44 50 28 1110.4PIP, CTSD, EGFR, ERBB2, PGR, ESR1
47testosterone44 60 24 119.7CTSD, EGFR, KRT18, ERBB2, MUC1, PGR
48progesterone44 28 60 24 1110.2KIT, ERBB2, KRT18, EGFR, CTSD, MUC1
49paraffin446.2PIP, PGR, ESR1, MUC1, S100A1, KIT
50estrogen446.2S100A1, ESR1, PGR, KIT, ERBB2, KRT18

GO Terms for genes affiliated with Microglandular Adenosis

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Cellular components related to Microglandular Adenosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5CTSD, EGFR, KIT, PIP
2apical plasma membraneGO:00163248.0EGFR, ERBB2, MUC1, PIP

Biological processes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:00108639.7KIT, ESR1
2signal transduction by phosphorylationGO:00230149.7ERBB2, KIT
3cellular response to estradiol stimulusGO:00713929.5EGFR, ESR1
4positive regulation of MAP kinase activityGO:00434069.5EGFR, ERBB2
5peptidyl-tyrosine phosphorylationGO:00181089.4EGFR, ERBB2, KIT
6phosphatidylinositol-mediated signalingGO:00480159.4EGFR, ERBB2, KIT
7protein autophosphorylationGO:00467779.3KIT, ERBB2, EGFR
8positive regulation of nitric oxide biosynthetic processGO:00454299.3ESR1, EGFR
9fibroblast growth factor receptor signaling pathwayGO:00085439.3KIT, ERBB2, EGFR
10Fc-epsilon receptor signaling pathwayGO:00380959.3EGFR, ERBB2, KIT
11epidermal growth factor receptor signaling pathwayGO:00071739.2KIT, ERBB2, EGFR
12positive regulation of fibroblast proliferationGO:00481469.0EGFR, ESR1
13neurotrophin TRK receptor signaling pathwayGO:00480119.0EGFR, ERBB2, KIT
14signal transductionGO:00071658.3PGR, ESR1, KIT, ERBB2, EGFR

Molecular functions related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.7EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:00302359.5EGFR, ESR1
3steroid bindingGO:00054969.4PGR, ESR1
4steroid hormone receptor activityGO:00037079.4ESR1, PGR
5aspartic-type endopeptidase activityGO:00041909.4CTSD, PIP
6receptor signaling protein tyrosine kinase activityGO:00047169.4EGFR, ERBB2, KIT
7transmembrane receptor protein tyrosine kinase activityGO:00047149.4KIT, ERBB2, EGFR
8protein tyrosine kinase activityGO:00047139.3KIT, ERBB2, EGFR
9glycoprotein bindingGO:00019488.8EGFR, PIP
10enzyme bindingGO:00198998.8EGFR, ESR1, PGR
11identical protein bindingGO:00428028.5ESR1, S100A1, ERBB2, EGFR
12protein bindingGO:00055156.8PGR, ESR1, MUC1, S100A1, KIT, ERBB2

Sources for Microglandular Adenosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet