MCID: MCR019
MIFTS: 46

Microglandular Adenosis malady

Download this MalaCard

Summaries for Microglandular Adenosis

About this section


Fully expand this MalaCard
MalaCards based summary: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and tubular adenocarcinoma. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and LKB1 signaling events. The compounds gold and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Microglandular Adenosis

About this section

Microglandular Adenosis, Aliases & Descriptions:

Name: Microglandular Adenosis 8 62
Adenosis of the Breast 8 62
 
Adenosis of Breast 62
Adenosis - Breast 8


External Ids:

Disease Ontology8 DOID:5998
MeSH34 D005348
SNOMED-CT57 270893004
NCIt39 C3484

Related Diseases for Microglandular Adenosis

About this section

Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5CTSD, MUC1, S100A1, KRT18
2tubular adenocarcinoma29.9ERBB2, MUC1, ESR1, PGR, CTSD
3adenocarcinoma28.9ESR1, ERBB2, PIP, PGR, MUC1, KRT18
4microglandular adenosis of breast10.6
5syringocystadenoma papilliferum10.5PIP
6nephrogenic adenoma10.5S100A1
7rosai-dorfman disease10.5CTSD
8cystadenocarcinoma10.5MUC1
9secretory meningioma10.5MUC1
10perineurioma10.5MUC1
11sinusitis10.4
12cerebral meningioma10.4PGR
13blunt duct adenosis of breast10.4
14apocrine adenosis of breast10.4
15fibrosclerosis of breast10.4
16hidradenoma10.4MUC1, PIP
17breast cyst10.4CTSD, PIP
18syringoma10.4S100A1, MUC1
19kidney cancer10.3EGFR
20hemangiopericytoma10.3S100A1, MUC1
21breast adenomyoepithelial adenosis10.3
22malignant fibroxanthoma10.3S100A1, MUC1
23spindle cell carcinoma10.3PGR, MUC1
24sertoli-leydig cell tumor10.3MUC1, PGR
25angiosarcoma10.3KRT18, MUC1
26elephantiasis10.2
27sertoli cell tumor10.2PGR, MUC1
28merkel cell carcinoma10.2KIT, MUC1
29reticulosarcoma10.2CTSD, MUC1
30uterine sarcoma10.2KIT, ESR1
31breast fibroadenoma10.2PGR, ESR1
32phyllode tumor10.2KIT, PGR
33adenosarcoma10.2PGR, ESR1
34sex cord-gonadal stromal tumor10.2PGR, MUC1
35meningioma10.2PGR, ESR1
36progesterone resistance10.2ESR1, PGR
37bilateral breast cancer10.2PGR, ESR1
38chordoma10.2KRT18, S100A1, MUC1
39uterine carcinosarcoma10.2ERBB2, KIT
40leiomyomatosis10.2PGR, ESR1
41myoma10.2PGR, ESR1
42uterine fibroid10.2ESR1, PGR
43lymphangioleiomyomatosis10.2ESR1, PGR
44dermatofibrosarcoma protuberans10.2KIT, S100A1, MUC1
45malignant peripheral nerve sheath tumor10.2MUC1, S100A1, KIT
46paraganglioma10.2KIT, S100A1
47neurofibroma10.2KIT, S100A1, MUC1
48synovial sarcoma10.2MUC1, KIT
49neurilemmoma10.2KIT, MUC1, S100A1
50cervical adenocarcinoma10.2PGR, ESR1

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Symptoms for Microglandular Adenosis

About this section

Drugs & Therapeutics for Microglandular Adenosis

About this section

Drug clinical trials:

Search ClinicalTrials for Microglandular Adenosis

Search NIH Clinical Center for Microglandular Adenosis

Genetic Tests for Microglandular Adenosis

About this section

Anatomical Context for Microglandular Adenosis

About this section

MalaCards organs/tissues related to Microglandular Adenosis:

32
Breast

Animal Models for Microglandular Adenosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Microglandular Adenosis:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, MUC1, KIT, KRT18, EGFR
2MP:00053718.4PGR, ESR1, KIT, ERBB2, EGFR
3MP:00030128.4PGR, ESR1, MUC1, KIT, EGFR
4MP:00028738.1PGR, MUC1, S100A1, KIT, ERBB2, EGFR
5MP:00020068.1PGR, ESR1, MUC1, KIT, ERBB2, EGFR
6MP:00053808.1PGR, ESR1, KIT, ERBB2, KRT18, EGFR
7MP:00107718.0PGR, ESR1, MUC1, KIT, ERBB2, EGFR
8MP:00053787.9CTSD, EGFR, KRT18, ERBB2, KIT, ESR1
9MP:00053697.9PGR, ESR1, S100A1, KIT, ERBB2, EGFR
10MP:00053907.8PGR, ESR1, KIT, ERBB2, EGFR
11MP:00053867.8PGR, ESR1, S100A1, KIT, ERBB2, CTSD
12MP:00053767.6PGR, ESR1, MUC1, KIT, ERBB2, EGFR
13MP:00107687.6PGR, ESR1, KIT, ERBB2, KRT18, EGFR
14MP:00053897.5PIP, PGR, ESR1, KIT, ERBB2, EGFR
15MP:00053977.5PIP, PGR, ESR1, KIT, EGFR, CTSD
16MP:00053817.4PIP, ESR1, MUC1, KIT, ERBB2, EGFR
17MP:00053877.3PIP, PGR, ESR1, KIT, EGFR, CTSD
18MP:00053847.2PIP, PGR, ESR1, KIT, ERBB2, EGFR
19MP:00053857.1PIP, PGR, ESR1, S100A1, KIT, ERBB2
20MP:00053797.0CTSD, PIP, PGR, ESR1, MUC1, KIT

Publications for Microglandular Adenosis

About this section

Articles related to Microglandular Adenosis:

(show all 31)
idTitleAuthorsYear
1
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. (25337263)
2014
2
Invasive breast carcinoma arising in microglandular adenosis: two case reports. (24454466)
2013
3
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
4
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
5
Microglandular adenosis. (21847399)
2011
6
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
7
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
8
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
9
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
10
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
11
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
12
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
13
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
14
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
15
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
16
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
17
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
18
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
19
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
20
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
21
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
22
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
23
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
24
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. (8458288)
1993
25
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993
26
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
27
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
28
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
29
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
30
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
31
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Variations for Microglandular Adenosis

About this section

Expression for genes affiliated with Microglandular Adenosis

About this section
Expression patterns in normal tissues for genes affiliated with Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

About this section

Pathways related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6EGFR, KIT
29.6ESR1, CTSD
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5EGFR, ERBB2
69.5EGFR, ERBB2
7
Show member pathways
9.4ESR1, PGR
8
Show member pathways
Nuclear Receptors37
9.4ESR1, PGR
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.3ESR1, EGFR
10
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.2EGFR, ERBB2, MUC1
119.2EGFR, ERBB2, MUC1
12
Show member pathways
Signal transduction PTEN pathway60
9.1EGFR, ERBB2, KIT
13
Show member pathways
9.1EGFR, ERBB2, KIT
149.1EGFR, ERBB2, KIT
159.1KIT, ERBB2, EGFR
16
Show member pathways
9.1KIT, ERBB2, EGFR
17
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.1ESR1, ERBB2, CTSD
188.9EGFR, ERBB2, ESR1
19
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.9ESR1, ERBB2, EGFR
208.9ESR1, ERBB2, EGFR
21
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
8.9ESR1, ERBB2, EGFR
22
Show member pathways
8.8KIT, ERBB2, EGFR, CTSD
23
Show member pathways
8.5EGFR, ERBB2, KIT, ESR1
24
Show member pathways
8.5ESR1, KIT, ERBB2, EGFR
25
Show member pathways
8.3EGFR, ERBB2, KIT, PIP
26
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
27
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
28
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
29
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
30
Show member pathways
7.0EGFR, KRT18, ERBB2, KIT, MUC1, ESR1

Compounds for genes affiliated with Microglandular Adenosis

About this section

Compounds related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1gold449.4CTSD, KIT, KRT18, MUC1
2sunitinib44 50 1111.3ERBB2, KIT, EGFR
3alkylating agents509.3ESR1, EGFR
4p002449.3KRT18, KIT, ERBB2, CTSD
5megestrol acetate449.3PGR, ESR1, ERBB2
6hematoxylin449.3KIT, KRT18, MUC1, S100A1
7adriamycin449.2ERBB2, MUC1, PGR, CTSD
8toremifene44 1110.2ERBB2, PGR, ESR1
9dmso449.2KRT18, MUC1, PGR, CTSD
10ici 164384449.1ESR1, PGR
11estrone sulfate44 2410.1PGR, CTSD, ESR1
12capecitabine44 50 1111.1ERBB2, EGFR, PGR, KIT
13mucicarmine449.1PIP, MUC1, S100A1
14formaldehyde44 2410.0MUC1, KIT, ERBB2, KRT18, CTSD
15steroidal449.0CTSD, ESR1, PGR
16b 723448.9S100A1, PIP, MUC1
17everolimus44 50 1110.9EGFR, ESR1, ERBB2, KIT
18exemestane44 50 61 1111.9EGFR, ESR1, PGR, ERBB2
19anastrozole44 50 1110.9PGR, ESR1, EGFR, ERBB2
20lapatinib44 50 1110.9ERBB2, EGFR, PGR, ESR1
21taxane448.8ERBB2, PGR, EGFR, ESR1
22letrozole44 50 61 1111.8EGFR, PGR, ESR1, ERBB2
23gefitinib44 50 1110.8ERBB2, KIT, ESR1, EGFR
24aspartate448.8CTSD, KRT18, ERBB2, KIT, PGR
25cyclophosphamide44 50 1110.7KRT18, ERBB2, ESR1, PGR, CTSD
26methotrexate50 44 1110.6PGR, ESR1, MUC1, KIT, ERBB2
27fulvestrant44 50 28 1111.6ERBB2, KRT18, EGFR, ESR1, PGR
284-hydroxytamoxifen448.6CTSD, EGFR, ESR1, PGR, ERBB2
29bicalutamide44 61 1110.6PIP, EGFR, ESR1
30agar448.5CTSD, MUC1, EGFR, KRT18, ERBB2, PGR
31dihydrotestosterone44 28 24 1111.5MUC1, PIP, ESR1, PGR
32geldanamycin44 50 61 1111.5KIT, PGR, ERBB2, EGFR, ESR1
33genistein44 28 61 2 24 1113.5PGR, EGFR, ERBB2, ESR1, CTSD
34cisplatin44 50 61 1111.4ESR1, CTSD, EGFR, ERBB2, MUC1
35estradiol44 24 1110.3MUC1, CTSD, PIP, ESR1, PGR
36progestin448.3ESR1, MUC1, CTSD, ERBB2, EGFR, PGR
37docetaxel44 50 61 1111.2KRT18, ESR1, PGR, KIT, EGFR, ERBB2
38paclitaxel44 50 1110.2EGFR, ERBB2, KIT, CTSD, ESR1, PGR
39cycloheximide448.1PGR, ERBB2, ESR1, EGFR, KIT, CTSD
40doxorubicin44 50 119.9ESR1, PGR, KRT18, EGFR, KIT, CTSD
41trastuzumab44 50 119.9CTSD, EGFR, ERBB2, KIT, MUC1, ESR1
425fluorouracil447.6CTSD, EGFR, KRT18, ERBB2, KIT, MUC1
43steroid447.6PGR, KRT18, CTSD, PIP, ESR1, ERBB2
44vegf447.5MUC1, ESR1, PGR, CTSD, ERBB2, KRT18
45retinoic acid44 248.5KRT18, MUC1, CTSD, EGFR, KIT, PGR
46tamoxifen44 50 28 1110.4PIP, CTSD, EGFR, ERBB2, PGR, ESR1
47testosterone44 61 24 119.7CTSD, EGFR, KRT18, ERBB2, MUC1, PGR
48progesterone44 28 61 24 1110.2KIT, ERBB2, KRT18, EGFR, CTSD, MUC1
49paraffin446.2PIP, PGR, ESR1, MUC1, S100A1, KIT
50estrogen446.2S100A1, ESR1, PGR, KIT, ERBB2, KRT18

GO Terms for genes affiliated with Microglandular Adenosis

About this section

Cellular components related to Microglandular Adenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CTSD, EGFR, KIT, PIP
2apical plasma membraneGO:0163248.0EGFR, ERBB2, MUC1, PIP

Biological processes related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.7KIT, ESR1
2signal transduction by phosphorylationGO:0230149.7ERBB2, KIT
3cellular response to estradiol stimulusGO:0713929.5EGFR, ESR1
4positive regulation of MAP kinase activityGO:0434069.5EGFR, ERBB2
5peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, ERBB2, KIT
6phosphatidylinositol-mediated signalingGO:0480159.4EGFR, ERBB2, KIT
7protein autophosphorylationGO:0467779.3KIT, ERBB2, EGFR
8positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, EGFR
9fibroblast growth factor receptor signaling pathwayGO:0085439.3KIT, ERBB2, EGFR
10Fc-epsilon receptor signaling pathwayGO:0380959.3EGFR, ERBB2, KIT
11epidermal growth factor receptor signaling pathwayGO:0071739.2KIT, ERBB2, EGFR
12positive regulation of fibroblast proliferationGO:0481469.0EGFR, ESR1
13neurotrophin TRK receptor signaling pathwayGO:0480119.0EGFR, ERBB2, KIT
14signal transductionGO:0071658.3PGR, ESR1, KIT, ERBB2, EGFR

Molecular functions related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:0302359.5EGFR, ESR1
3steroid bindingGO:0054969.4PGR, ESR1
4steroid hormone receptor activityGO:0037079.4ESR1, PGR
5aspartic-type endopeptidase activityGO:0041909.4CTSD, PIP
6receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2, KIT
7transmembrane receptor protein tyrosine kinase activityGO:0047149.4KIT, ERBB2, EGFR
8protein tyrosine kinase activityGO:0047139.3KIT, ERBB2, EGFR
9glycoprotein bindingGO:0019488.8EGFR, PIP
10enzyme bindingGO:0198998.8EGFR, ESR1, PGR
11identical protein bindingGO:0428028.5ESR1, S100A1, ERBB2, EGFR
12protein bindingGO:0055156.8PGR, ESR1, MUC1, S100A1, KIT, ERBB2

Products for genes affiliated with Microglandular Adenosis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Microglandular Adenosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet