MCID: MCR019
MIFTS: 46

Microglandular Adenosis malady

Summaries for Microglandular Adenosis

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34MalaCards
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MalaCards: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and adenoid cystic carcinoma. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and LKB1 signaling events. The compounds gold and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Microglandular Adenosis

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9Disease Ontology, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT
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Aliases & Descriptions:

microglandular adenosis 9
adenosis of the breast 9
adenosis of breast 63
adenosis - breast 9


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Disease Ontology9 DOID:5998
MeSH36 D005348
SNOMED-CT59 270893004
NCIt41 C3484

Related Diseases for Microglandular Adenosis

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18GeneCards, 19GeneDecks
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Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4MUC1, S100A1, KRT18, CTSD
2adenoid cystic carcinoma30.4ERBB2, KIT, S100A1, MUC1
3tubular adenocarcinoma30.3PGR, ESR1, MUC1, ERBB2, CTSD
4adenocarcinoma30.0PIP, PGR, ESR1, MUC1, ERBB2, KRT18
5breast cancer30.0PIP, PGR, ESR1, MUC1, KIT, ERBB2
6microglandular adenosis of breast10.5
7sinusitis10.4
8fibrosclerosis of breast10.4
9breast adenomyoepithelial adenosis10.3
10adenoiditis10.3
11apocrine adenosis of breast10.2
12blunt duct adenosis of breast10.2
13elephantiasis10.2
14sclerosing adenosis of breast10.1
15syringocystadenoma papilliferum10.1PIP
16nephrogenic adenoma10.1S100A1
17rosai-dorfman disease10.1CTSD
18glomus tumor10.1S100A1
19cystadenocarcinoma10.1MUC1
20secretory meningioma10.1MUC1
21perineurioma10.1MUC1
22cerebral meningioma10.1PGR
23hidradenoma10.1MUC1, PIP
24breast cyst10.1PIP, CTSD
25syringoma10.1MUC1, S100A1
26kidney cancer10.1EGFR
27hemangiopericytoma10.1MUC1, S100A1
28malignant fibroxanthoma10.1MUC1, S100A1
29spindle cell carcinoma10.1MUC1, PGR
30sertoli-leydig cell tumor10.1PGR, MUC1
31angiosarcoma10.1MUC1, KRT18
32sertoli cell tumor10.1PGR, MUC1
33merkel cell carcinoma10.1MUC1, KIT
34reticulosarcoma10.1MUC1, CTSD
35phyllode tumor10.1PGR, KIT
36breast fibroadenoma10.1ESR1, PGR
37uterine sarcoma10.1ESR1, KIT
38adenosarcoma10.1PGR, ESR1
39sex cord-gonadal stromal tumor10.0PGR, MUC1
40meningioma10.0ESR1, PGR
41progesterone resistance10.0PGR, ESR1
42bilateral breast cancer10.0PGR, ESR1
43chordoma10.0MUC1, S100A1, KRT18
44uterine carcinosarcoma10.0KIT, ERBB2
45leiomyomatosis10.0PGR, ESR1
46myoma10.0ESR1, PGR
47paraganglioma10.0S100A1, KIT
48uterine fibroid10.0PGR, ESR1
49lymphangioleiomyomatosis10.0PGR, ESR1
50dermatofibrosarcoma protuberans10.0MUC1, S100A1, KIT

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Symptoms for Microglandular Adenosis

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Drugs & Therapeutics for Microglandular Adenosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Microglandular Adenosis

Drug clinical trials:

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Search NIH Clinical Center for Microglandular Adenosis

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Genetic Tests for Microglandular Adenosis

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Anatomical Context for Microglandular Adenosis

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34MalaCards
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MalaCards organs/tissues related to Microglandular Adenosis:

34
Breast

Animal Models for Microglandular Adenosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Microglandular Adenosis:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, MUC1, KIT, KRT18, EGFR
2MP:00053718.4PGR, ESR1, KIT, ERBB2, EGFR
3MP:00030128.4PGR, ESR1, MUC1, KIT, EGFR
4MP:00028738.1PGR, MUC1, S100A1, KIT, ERBB2, EGFR
5MP:00020068.1PGR, ESR1, MUC1, KIT, ERBB2, EGFR
6MP:00053808.1PGR, ESR1, KIT, ERBB2, KRT18, EGFR
7MP:00107718.0PGR, ESR1, MUC1, KIT, ERBB2, EGFR
8MP:00053787.9CTSD, EGFR, KRT18, ERBB2, KIT, ESR1
9MP:00053697.9PGR, ESR1, S100A1, KIT, ERBB2, EGFR
10MP:00053907.8PGR, ESR1, KIT, ERBB2, EGFR
11MP:00053867.8PGR, ESR1, S100A1, KIT, ERBB2, CTSD
12MP:00053767.6PGR, ESR1, MUC1, KIT, ERBB2, EGFR
13MP:00107687.6PGR, ESR1, KIT, ERBB2, KRT18, EGFR
14MP:00053897.5PIP, PGR, ESR1, KIT, ERBB2, EGFR
15MP:00053977.5PIP, PGR, ESR1, KIT, EGFR, CTSD
16MP:00053817.4PIP, ESR1, MUC1, KIT, ERBB2, EGFR
17MP:00053877.3PIP, PGR, ESR1, KIT, EGFR, CTSD
18MP:00053847.2PIP, PGR, ESR1, KIT, ERBB2, EGFR
19MP:00053857.1PIP, PGR, ESR1, S100A1, KIT, ERBB2
20MP:00053797.0CTSD, PIP, PGR, ESR1, MUC1, KIT

Publications for Microglandular Adenosis

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53PubMed
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Articles related to Microglandular Adenosis:

(show all 30)
idTitleAuthorsYear
1
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? (23584829)
2013
2
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
3
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
4
Microglandular adenosis. (21847399)
2011
5
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
6
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
7
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
8
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
9
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
10
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
11
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
12
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
13
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
14
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. (12883237)
2003
15
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
16
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
17
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
18
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
19
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
20
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
21
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
22
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
23
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
24
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993
25
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
26
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
27
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
28
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
29
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
30
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Variations for Microglandular Adenosis

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Expression for genes affiliated with Microglandular Adenosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

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51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters, 58SinoBiological, 31KEGG, 5Cell Signaling Technology
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Pathways related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6EGFR, KIT
29.6ESR1, CTSD
39.5EGFR, ERBB2
4
Show member pathways
9.5EGFR, ERBB2
59.5EGFR, ERBB2
69.5EGFR, ERBB2
7
Show member pathways
9.4ESR1, PGR
8
Show member pathways
Nuclear Receptors39
9.4ESR1, PGR
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway61
9.3ESR1, EGFR
10
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.2EGFR, ERBB2, MUC1
119.2EGFR, ERBB2, MUC1
12
Show member pathways
Signal transduction PTEN pathway61
9.1EGFR, ERBB2, KIT
13
Show member pathways
9.1EGFR, ERBB2, KIT
149.1EGFR, ERBB2, KIT
159.1KIT, ERBB2, EGFR
16
Show member pathways
9.1KIT, ERBB2, EGFR
17
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.1ESR1, ERBB2, CTSD
188.9EGFR, ERBB2, ESR1
19
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.9ESR1, ERBB2, EGFR
208.9ESR1, ERBB2, EGFR
21
Show member pathways
Development Ligand independent activation of ESR1 and ESR261
8.9ESR1, ERBB2, EGFR
22
Show member pathways
8.8KIT, ERBB2, EGFR, CTSD
23
Show member pathways
8.5EGFR, ERBB2, KIT, ESR1
24
Show member pathways
8.5ESR1, KIT, ERBB2, EGFR
25
Show member pathways
8.3EGFR, ERBB2, KIT, PIP
26
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
27
Show member pathways
8.3PIP, KIT, ERBB2, EGFR
28
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
29
Show member pathways
8.1PGR, ESR1, KIT, ERBB2, EGFR
30
Show member pathways
7.0EGFR, KRT18, ERBB2, KIT, MUC1, ESR1

Compounds for genes affiliated with Microglandular Adenosis

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1gold469.4CTSD, KIT, KRT18, MUC1
2sunitinib46 52 1211.3ERBB2, KIT, EGFR
3alkylating agents529.3ESR1, EGFR
4p002469.3KRT18, KIT, ERBB2, CTSD
5megestrol acetate469.3PGR, ESR1, ERBB2
6hematoxylin469.3KIT, KRT18, MUC1, S100A1
7adriamycin469.2ERBB2, MUC1, PGR, CTSD
8toremifene46 1210.2ERBB2, PGR, ESR1
9dmso469.2KRT18, MUC1, PGR, CTSD
10ici 164384469.1ESR1, PGR
11estrone sulfate46 2510.1PGR, CTSD, ESR1
12capecitabine46 52 1211.1ERBB2, EGFR, PGR, KIT
13mucicarmine469.1PIP, MUC1, S100A1
14formaldehyde46 2510.0MUC1, KIT, ERBB2, KRT18, CTSD
15steroidal469.0CTSD, ESR1, PGR
16b 723468.9S100A1, PIP, MUC1
17everolimus46 52 1210.9EGFR, ESR1, ERBB2, KIT
18exemestane46 52 62 1211.9EGFR, ESR1, PGR, ERBB2
19anastrozole46 52 1210.9PGR, ESR1, EGFR, ERBB2
20lapatinib46 52 1210.9ERBB2, EGFR, PGR, ESR1
21taxane468.8ERBB2, PGR, EGFR, ESR1
22letrozole46 52 62 1211.8EGFR, PGR, ESR1, ERBB2
23gefitinib46 52 1210.8ERBB2, KIT, ESR1, EGFR
24aspartate468.8CTSD, KRT18, ERBB2, KIT, PGR
25cyclophosphamide46 52 1210.7KRT18, ERBB2, ESR1, PGR, CTSD
26methotrexate52 46 1210.6PGR, ESR1, MUC1, KIT, ERBB2
27fulvestrant46 52 30 1211.6ERBB2, KRT18, EGFR, ESR1, PGR
284-hydroxytamoxifen468.6CTSD, EGFR, ESR1, PGR, ERBB2
29bicalutamide46 62 1210.6PIP, EGFR, ESR1
30agar468.5CTSD, MUC1, EGFR, KRT18, ERBB2, PGR
31dihydrotestosterone46 30 25 1211.5MUC1, PIP, ESR1, PGR
32geldanamycin46 52 62 1211.5KIT, PGR, ERBB2, EGFR, ESR1
33genistein46 30 62 3 25 1213.5PGR, EGFR, ERBB2, ESR1, CTSD
34cisplatin46 52 62 1211.4ESR1, CTSD, EGFR, ERBB2, MUC1
35estradiol46 25 1210.3MUC1, CTSD, PIP, ESR1, PGR
36progestin468.3ESR1, MUC1, CTSD, ERBB2, EGFR, PGR
37docetaxel46 52 62 1211.2KRT18, ESR1, PGR, KIT, EGFR, ERBB2
38paclitaxel46 52 1210.2EGFR, ERBB2, KIT, CTSD, ESR1, PGR
39cycloheximide468.1PGR, ERBB2, ESR1, EGFR, KIT, CTSD
40doxorubicin46 52 129.9ESR1, PGR, KRT18, EGFR, KIT, CTSD
41trastuzumab46 52 129.9CTSD, EGFR, ERBB2, KIT, MUC1, ESR1
425fluorouracil467.6CTSD, EGFR, KRT18, ERBB2, KIT, MUC1
43steroid467.6PGR, KRT18, CTSD, PIP, ESR1, ERBB2
44vegf467.5MUC1, ESR1, PGR, CTSD, ERBB2, KRT18
45retinoic acid46 258.5KRT18, MUC1, CTSD, EGFR, KIT, PGR
46tamoxifen46 52 30 1210.4PIP, CTSD, EGFR, ERBB2, PGR, ESR1
47testosterone46 62 25 129.7CTSD, EGFR, KRT18, ERBB2, MUC1, PGR
48progesterone46 30 62 25 1210.2KIT, ERBB2, KRT18, EGFR, CTSD, MUC1
49paraffin466.2PIP, PGR, ESR1, MUC1, S100A1, KIT
50estrogen466.2S100A1, ESR1, PGR, KIT, ERBB2, KRT18

GO Terms for genes affiliated with Microglandular Adenosis

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17Gene Ontology
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Cellular components related to Microglandular Adenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CTSD, EGFR, KIT, PIP
2apical plasma membraneGO:0163248.0EGFR, ERBB2, MUC1, PIP

Biological processes related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.7KIT, ESR1
2signal transduction by phosphorylationGO:0230149.7ERBB2, KIT
3cellular response to estradiol stimulusGO:0713929.5EGFR, ESR1
4positive regulation of MAP kinase activityGO:0434069.5EGFR, ERBB2
5peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, ERBB2, KIT
6phosphatidylinositol-mediated signalingGO:0480159.4EGFR, ERBB2, KIT
7protein autophosphorylationGO:0467779.3KIT, ERBB2, EGFR
8positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, EGFR
9fibroblast growth factor receptor signaling pathwayGO:0085439.3KIT, ERBB2, EGFR
10Fc-epsilon receptor signaling pathwayGO:0380959.3EGFR, ERBB2, KIT
11epidermal growth factor receptor signaling pathwayGO:0071739.2KIT, ERBB2, EGFR
12positive regulation of fibroblast proliferationGO:0481469.0EGFR, ESR1
13neurotrophin TRK receptor signaling pathwayGO:0480119.0EGFR, ERBB2, KIT
14signal transductionGO:0071658.3PGR, ESR1, KIT, ERBB2, EGFR

Molecular functions related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:0302359.5EGFR, ESR1
3steroid bindingGO:0054969.4PGR, ESR1
4steroid hormone receptor activityGO:0037079.4ESR1, PGR
5aspartic-type endopeptidase activityGO:0041909.4CTSD, PIP
6receptor signaling protein tyrosine kinase activityGO:0047169.4EGFR, ERBB2, KIT
7transmembrane receptor protein tyrosine kinase activityGO:0047149.4KIT, ERBB2, EGFR
8protein tyrosine kinase activityGO:0047139.3KIT, ERBB2, EGFR
9glycoprotein bindingGO:0019488.8EGFR, PIP
10enzyme bindingGO:0198998.8EGFR, ESR1, PGR
11identical protein bindingGO:0428028.5ESR1, S100A1, ERBB2, EGFR
12protein bindingGO:0055156.8PGR, ESR1, MUC1, S100A1, KIT, ERBB2

Products for genes affiliated with Microglandular Adenosis

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  • Antibodies
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Sources for Microglandular Adenosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet