MCID: MCR019
MIFTS: 44

Microglandular Adenosis malady

Summaries for Microglandular Adenosis

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32MalaCards
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MalaCards: Microglandular Adenosis, also known as adenosis of the breast, is related to adenoma and adenoid cystic carcinoma. An important gene associated with Microglandular Adenosis is CTSD (cathepsin D), and among its related pathways are Nanog in Mammalian ESC Pluripotency and SHC1 events in ERBB2 signaling. The compounds ici 164384 and Ethynodiol Diacetate have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Microglandular Adenosis

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8Disease Ontology, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

microglandular adenosis 8
adenosis of the breast 8
adenosis of breast 60
adenosis - breast 8


External Ids:

Disease Ontology8 DOID:5998
MeSH34 D005348
SNOMED-CT56 270893004
NCIt39 C3484

Related Diseases for Microglandular Adenosis

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17GeneCards, 18GeneDecks
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Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.3CTSD, S100A1, MUC1, KRT18
2adenoid cystic carcinoma30.3KIT, S100A1, MUC1, ERBB2
3tubular adenocarcinoma30.3CTSD, MUC1, PGR, ERBB2, ESR1
4adenocarcinoma30.2MUC1, ESR1, ERBB2, KRT18, PGR, CTSD
5breast cancer30.2MUC1, ERBB2, ESR1, KIT, KRT18, CTSD
6microglandular adenosis of breast10.9
7fibrosclerosis of breast10.3
8breast adenomyoepithelial adenosis10.2
9acinic cell breast carcinoma10.2
10breast apocrine carcinoma10.2
11apocrine adenosis of breast10.2
12breast adenoid cystic carcinoma10.2
13adenoiditis10.2
14breast adenocarcinoma10.2
15in situ carcinoma10.2
16blunt duct adenosis of breast10.2
17elephantiasis10.2
18sclerosing adenosis of breast10.1
19gastritis10.0KRT18
20azoospermia10.0KRT18
21desmoid tumor10.0KIT
22hepatocellular carcinoma10.0KRT18
23germ cell tumors10.0KIT
24syringocystadenoma papilliferum10.0PIP
25liver cirrhosis10.0KRT18
26hemangioblastoma10.0MUC1
27rosai-dorfman disease10.0CTSD
28cystadenocarcinoma10.0MUC1
29rhabdomyosarcoma10.0S100A1
30rhabdoid tumor10.0MUC1
31secretory meningioma10.0MUC1
32cerebral meningioma10.0PGR
33interstitial lung disease10.0MUC1
34renal oncocytoma10.0S100A1
35astrocytoma10.0EGFR
36acute leukemia10.0KIT
37cholesteatoma10.0S100A1
38hidradenoma10.0PIP, MUC1
39nephrogenic adenoma10.0S100A1
40medulloblastoma10.0ERBB2
41esophageal cancer10.0EGFR
42perineurioma10.0MUC1
43angiosarcoma10.0MUC1, KRT18
44anaplastic astrocytoma10.0EGFR
45breast cyst10.0PIP, CTSD
46oral cancer10.0EGFR
47osteosarcoma10.0ESR1
48myoepithelioma10.0S100A1
49oligodendroglioma10.0EGFR
50uterine carcinosarcoma10.0ERBB2, KIT

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to microglandular adenosis

Clinical Features for Microglandular Adenosis

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Drugs & Therapeutics for Microglandular Adenosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Microglandular Adenosis

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Anatomical Context for Microglandular Adenosis

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32MalaCards
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MalaCards organs/tissues related to Microglandular Adenosis:

32
Breast

Animal Models for Microglandular Adenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Microglandular Adenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.1ESR1
2MP:00053708.4EGFR, MUC1, KIT, KRT18, ESR1
3MP:00053818.3CTSD, EGFR, MUC1, KIT, ERBB2, ESR1
4MP:00020068.2EGFR, MUC1, PGR, KIT, ERBB2, ESR1
5MP:00053808.2EGFR, PGR, KIT, KRT18, ERBB2, ESR1
6MP:00030128.2EGFR, MUC1, PGR, KIT, ESR1
7MP:00028738.0S100A1, EGFR, MUC1, PGR, KIT, ERBB2
8MP:00053798.0ESR1, CTSD, EGFR, MUC1, PGR, KIT
9MP:00053857.9ESR1, ERBB2, KIT, PGR, EGFR, S100A1

Publications for Microglandular Adenosis

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50PubMed
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Articles related to Microglandular Adenosis:

(show all 31)
idTitleAuthorsYear
1
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? (23584829)
2013
2
Acinic cell carcinoma of the breast arising in microglandular adenosis. (24369519)
2013
3
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. (22486256)
2012
4
Microglandular adenosis. (21847399)
2011
5
Microglandular adenosis with transition to breast carcinoma: a series of three cases. (21753716)
2011
6
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. (20846267)
2010
7
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. (20922408)
2010
8
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. (19047897)
2009
9
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. (19824997)
2009
10
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. (19922592)
2009
11
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. (18300793)
2008
12
Breast carcinoma arising in microglandular adenosis: a review of the literature. (17824796)
2007
13
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. (15129910)
2004
14
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. (12883237)
2003
15
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. (12521372)
2003
16
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. (12042957)
2002
17
Carcinoma arising in microglandular adenosis of the breast. (12574855)
2001
18
Mammary carcinoma arising in microglandular adenosis: a case report]. (11852363)
2001
19
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. (11494007)
2000
20
Microglandular adenosis arising in chronic paranasal sinusitis. (10841649)
2000
21
Microglandular adenosis arising in a chronic paranasal sinusitis. (11150125)
2000
22
Carcinoma of the breast arising in microglandular adenosis. (7504394)
1993
23
Immunohistochemical profile and differential diagnosis of microglandular adenosis. (8346180)
1993
24
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. (8458288)
1993
25
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993
26
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. (1710101)
1991
27
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. (2101677)
1990
28
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. (3706610)
1986
29
Microglandular adenosis of the breast--a lesion simulating tubular carcinoma. (6852780)
1983
30
Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. (6859388)
1983
31
Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. (6660348)
1983

Genetic Variations for Microglandular Adenosis

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Expression for genes affiliated with Microglandular Adenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for genes affiliated with Microglandular Adenosis

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 55SinoBiological
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Pathways related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7EGFR, KIT
2
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9.6ERBB2, EGFR
3
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9.3EGFR, KIT, ERBB2
4
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9.3ERBB2, KIT, EGFR
59.3ERBB2, KIT, EGFR
6
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9.3EGFR, KIT, ERBB2
79.3ERBB2, MUC1, EGFR
8
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9.3ERBB2, MUC1, EGFR
9
Development Prolactin receptor signaling
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9.3ESR1, ERBB2, CTSD
109.1EGFR, ERBB2, ESR1
11
Development Ligand-independent activation of ESR1 and ESR2
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9.1EGFR, ERBB2, ESR1
12
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8.7PIP, EGFR, KIT, ERBB2
13
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8.7EGFR, KIT, ERBB2, PIP
14
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8.6PIP, KRT18, ERBB2, ESR1
15
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8.4ESR1, ERBB2, KIT, PGR, EGFR

Compounds for genes affiliated with Microglandular Adenosis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1ici 164384449.8ESR1, PGR
2Ethynodiol Diacetate119.8PGR, ESR1
3hematoxylin449.7S100A1, KIT, KRT18
4everolimus49 44 1111.6EGFR, KIT, ERBB2
5sunitinib44 49 1111.6ERBB2, KIT, EGFR
6Allylestrenol119.6ESR1, PGR
7megestrol acetate449.5ERBB2, ESR1, PGR
8gold449.5CTSD, MUC1, KIT, KRT18
9toremifene44 1110.5PGR, ERBB2, ESR1
10idoxifene449.5PGR, ESR1
11p002449.5KIT, ERBB2, KRT18, CTSD
12steroidal449.4CTSD, ESR1, PGR
13estrone sulfate44 2410.4PGR, CTSD, ESR1
14adriamycin449.4CTSD, ERBB2, PGR, MUC1
15capecitabine44 49 1111.3ERBB2, EGFR, PGR, KIT
16mucicarmine449.3S100A1, PIP, MUC1
17Etonogestrel119.3ESR1, PGR
18b 723449.2MUC1, S100A1, PIP
19dihydrotestosterone44 28 11 2412.2ESR1, PGR, PIP
20formaldehyde44 2410.2MUC1, KIT, KRT18, ERBB2, CTSD
21dmso449.2PGR, CTSD, KRT18, MUC1
22anastrozole44 1110.1PGR, ESR1, ERBB2, EGFR
23exemestane49 44 59 1112.1EGFR, ESR1, ERBB2, PGR
24gefitinib44 49 1111.1ERBB2, KIT, ESR1, EGFR
25lapatinib44 49 1111.1ESR1, ERBB2, PGR, EGFR
26taxane449.1EGFR, PGR, ERBB2, ESR1
27letrozole44 49 59 1112.1EGFR, PGR, ERBB2, ESR1
28bicalutamide44 59 1111.1PIP, ESR1, EGFR
29cyclophosphamide44 49 1111.0ERBB2, ESR1, KRT18, PGR, CTSD
30methotrexate44 49 1110.9PGR, MUC1, ESR1, ERBB2, KIT
31fulvestrant44 49 28 1111.9EGFR, ESR1, KRT18, PGR, ERBB2
32aspartate448.9CTSD, PGR, KIT, KRT18, ERBB2
334-hydroxytamoxifen448.8ESR1, PGR, CTSD, ERBB2, EGFR
34paclitaxel44 49 1110.8ESR1, ERBB2, PGR, EGFR, CTSD
35geldanamycin44 49 59 1111.8PGR, ERBB2, KIT, EGFR, ESR1
36steroid448.7PIP, ESR1, ERBB2, KRT18, CTSD
37agar448.7PGR, ERBB2, KRT18, MUC1, CTSD, EGFR
38genistein44 28 59 2 11 2413.7EGFR, ERBB2, CTSD, ESR1, PGR
39estradiol44 11 2410.6ESR1, PGR, MUC1, PIP, CTSD
40docetaxel44 49 59 1111.5ERBB2, KRT18, ESR1, EGFR, KIT, PGR
41progestin448.5MUC1, EGFR, ESR1, ERBB2, PGR, CTSD
42doxorubicin44 49 1110.2CTSD, EGFR, PGR, KIT, KRT18, ERBB2
43trastuzumab44 49 1110.2ERBB2, CTSD, EGFR, MUC1, KIT, ESR1
445fluorouracil447.9EGFR, ESR1, ERBB2, KRT18, KIT, PGR
45tamoxifen44 49 28 1110.9CTSD, PIP, EGFR, PGR, ERBB2, MUC1
46vegf447.9KIT, KRT18, ERBB2, ESR1, EGFR, CTSD
47retinoic acid44 248.8KRT18, KIT, CTSD, PGR, MUC1, EGFR
48testosterone44 59 11 2410.3KRT18, ERBB2, PGR, ESR1, MUC1, EGFR
49paraffin446.8PIP, CTSD, EGFR, MUC1, PGR, KIT
50progesterone44 59 28 11 2410.8KRT18, S100A1, PIP, EGFR, MUC1, PGR

GO Terms for genes affiliated with Microglandular Adenosis

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16Gene Ontology
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Biological processes related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:0230149.9ERBB2, KIT
2positive regulation of phospholipase C activityGO:0108639.8ESR1, KIT
3cellular response to estradiol stimulusGO:0713929.6EGFR, ESR1
4phosphatidylinositol-mediated signalingGO:0480159.4EGFR, KIT, ERBB2
5protein autophosphorylationGO:0467779.3ERBB2, KIT, EGFR
6epidermal growth factor receptor signaling pathwayGO:0071739.3ERBB2, KIT, EGFR
7fibroblast growth factor receptor signaling pathwayGO:0085439.2EGFR, KIT, ERBB2
8Fc-epsilon receptor signaling pathwayGO:0380959.0ERBB2, KIT, EGFR
9signal transductionGO:0071658.5EGFR, PGR, KIT, ERBB2, ESR1

Molecular functions related to Microglandular Adenosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7ERBB2, EGFR
2steroid bindingGO:0054969.6ESR1, PGR
3nitric-oxide synthase regulator activityGO:0302359.6EGFR, ESR1
4receptor signaling protein tyrosine kinase activityGO:0047169.5ERBB2, KIT, EGFR
5transmembrane receptor protein tyrosine kinase activityGO:0047149.4ERBB2, KIT, EGFR
6protein tyrosine kinase activityGO:0047139.3ERBB2, KIT, EGFR
7identical protein bindingGO:0428028.3S100A1, EGFR, ERBB2, ESR1
8protein bindingGO:0055156.8S100A1, CTSD, EGFR, MUC1, PGR, KIT

Products for genes affiliated with Microglandular Adenosis

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Sources for Microglandular Adenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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