Micropenis malady

Wikipedia: Micropenis is an unusually small penis. A common criterion is a dorsal (measured on top) erect penile...⁴⁴ more...

MalaCards: Micropenis is related to 5-alpha reductase deficiency and perineal hypospadias. An important gene associated with Micropenis is INPP5E (inositol polyphosphate-5-phosphatase, 72 kDa), and among its related pathways are Steroid hormone biosynthesis and Translation_Non-genomic (rapid) action of Androgen Receptor. The compounds dutasteride and goserelin have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and renal/urinary system.

micropenis 7 32

Diseases related to micropenis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 146)

id	Related Disease	Score	Top Affiliating Genes
1	5-alpha reductase deficiency	27.4	CGA, CGB5, SRD5A1, SRD5A2
2	perineal hypospadias	13.3	SRD5A2, AR
3	hypothalamic disease	13.3	GNRH1, CGA
4	androgen insensitivity syndrome, partial	13.3	SRD5A1, AR
5	robinow syndrome	13.3	GNRH1, CGA
6	prostate cancer	13.3	SRD5A1, AR
7	complete androgen insensitivity syndrome	13.2	AR, CGA
8	prostate disease	13.2	SRD5A1, AR
9	gonadotropin deficiency	13.2	CGA, GNRH1
10	leydig cell adenoma	13.1	LHCGR, CGA, GNRH1
11	nonseminomatous germ cell tumor	13.1	CGB5, CGA
12	androgenetic alopecia	13.1	SRD5A2, SRD5A1, AR
13	epithelioid trophoblastic tumor	13.1	CGB5, CGA
14	trophoblastic neoplasm	13.1	CGB5, CGA
15	gestational trophoblastic tumor	13.0	CGA, CGB5
16	thyroid hormone resistance syndrome	13.0	GNRH1, IGFBP3
17	myelomeningocele	13.0	GNRH1, IGFBP3
18	cushing's syndrome	13.0	CYP17A1, GNRH1, LHCGR
19	familial prostate cancer	13.0	AR, CYP17A1, SRD5A2
20	ectopic pregnancy	13.0	CGA, CGB5
21	male breast cancer	13.0	SRD5A1, CYP17A1, AR
22	glanders	13.0	INPP5E, IGFBP3, GNRH1
23	male infertility	12.9	GNRH1, AR, CGA
24	hydrocele	12.9	CGB5, CGA
25	fragile x-associated primary ovarian insufficiency	12.9	CGA, GNRH1
26	gonadal disease	12.9	NR5A1, GNRH1
27	tumors of adrenal cortex	12.9	NR5A1, LHCGR
28	aorta atresia	12.9	GNRH1, IGFBP3, CGA
29	prostate carcinoma	12.9	AR, CYP17A1, SRD5A2
30	hypopituitarism	12.9	GNRH1, IGFBP3, CGA
31	anencephaly	12.9	CGA, CGB5
32	ovarian cyst	12.8	GNRH1, CGB5, CGA
33	varicocele	12.8	GNRH1, CGB5, CGA
34	beta thalassemia	12.8	GNRH1, IGFBP3, CGA
35	breast cyst	12.8	SRD5A1, IGFBP3, CGB5
36	transsexualism	12.7	SRD5A2, CYP17A1, GNRH1, AR
37	neuromuscular disease	12.7	GNRH1, AR, ARNT
38	anovulation	12.7	SRD5A1, GNRH1, IGFBP3, CGA
39	46, xy disorders of sexual development	12.7	AR, CYP17A1, NR5A1
40	prostate cancer, progression of	12.7	SRD5A2, SRD5A1, GNRH1, AR
41	adrenocortical carcinoma	12.7	AHR, NR5A1, CYP17A1
42	hyperinsulinism	12.7	IGFBP3, GNRH1, CYP17A1
43	placental site trophoblastic tumor	12.7	CGA, CGB5
44	sex reversal	12.6	CGA, AR, NR5A1
45	prostatic hypertrophy	12.6	SRD5A1, GNRH1, IGFBP3, AR
46	vaginitis	12.6	SRD5A1, GNRH1, AR, CGA
47	ductal carcinoma in situ	12.6	AR, IGFBP3, SRD5A1
48	ovarian hyperstimulation syndrome	12.6	LHCGR, CGA, CGB5, GNRH1
49	graves' disease	12.6	GNRH1, IGFBP3, CGA, LHCGR
50	sycp3-related pregnancy loss, susceptibility to	12.6	AHR, GNRH1, CGB5, CGA

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to micropenis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.4	AHR, GNRH1, AR, ARNT, AHRR
2	renal/urinary system phenotype	MP:0005367	8.2	AHR, ARNT, AR, INPP5E, GNRH1, LHCGR
3	growth/size phenotype	MP:0005378	7.2	GNRH1, CGA, ARNT, AR, INPP5E, IGFBP3
4	reproductive system phenotype	MP:0005389	7.2	CGA, ARNT, AR, GNRH1, CYP17A1, SRD5A1
5	endocrine/exocrine gland phenotype	MP:0005379	7.1	LHCGR, CGA, ARNT, AR, IGFBP3, GNRH1
6	homeostasis/metabolism phenotype	MP:0005376	6.6	AHRR, LHCGR, CGA, ARNT, IGFBP3, GNRH1

Articles related to micropenis:

id	Title	Authors	Year	Affiliating Genes
1	Isolated micropenis reveals partial androgen insensit ivity syndrome confirmed by molecular analysis. (20305676)	Bhangoo A.... Sultan C.	2010	AR
2	Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. (15758562)	Soneda S.... Ogata T.	2005	AHR, AHRR
3	Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1. (16127213)	Wada Y.... Ogata T.	2005	NR5A1
4	Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis. (15201804)	Ishii T.... Ogata T.	2004	AR, SRD5A2
5	Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. (12843198)	Sasaki G.... Matsuo N.	2003	SRD5A2
6	Micropenis with testicular regression, low LH levels, and poor androgen and HCG responses: a distinct syndrome? (11992480)	Parisi M.A.... Pagon R.A.	2002	CGA
7	Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. (11835227)	Fujita H.... Kosaki K.	2002	AHR, ARNT, AHRR
8	Micropenis and the AR Gene: mutation and CAG repeat-length analysis. (11701709)	Ishii T.... Matsuo N.	2001	AR
9	5 alpha-reductase deficiency in patients with micropenis. (9061573)	Gad Y.Z.... El-Ridi R.	1997	SRD5A1, CGB5

Genes related to micropenis according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	INPP5E	inositol polyphosphate-5-phosphatase, 72 kDa	11.0
2	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0
3	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)	11.0	Publications
4	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
5	AHR	aryl hydrocarbon receptor	11.0	Publications
6	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0
7	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
8	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0
9	AR	androgen receptor	11.0	Publications
10	IGFBP3	insulin-like growth factor binding protein 3	11.0
11	ARNT	aryl hydrocarbon receptor nuclear translocator	11.0	Publications
12	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
13	AHRR	aryl-hydrocarbon receptor repressor	11.0	Publications
14	EXT2	exostosin 2	11.0
15	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications

Pathways related to micropenis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Steroid hormone biosynthesis20	9.8	CYP17A1, SRD5A1, SRD5A2
2	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.6	AR, SRD5A2, SRD5A1
3	Translation Non-genomic (rapid) action of Androgen Receptor10	9.6	AR, SRD5A1, SRD5A2
4	Development_Role of Activin A in cell differentiation and proliferation41	9.6	NR5A1, CGA, LHCGR
5	Development Role of Activin A in cell differentiation and proliferation10	9.5	CGA, LHCGR, NR5A1
6	Transcription_Androgen Receptor nuclear signaling41	9.5	AR, SRD5A1, SRD5A2
7	Metabolism of lipids and lipoproteins38	9.4	SRD5A2, SRD5A1, CYP17A1, INPP5E
8	AHR Pathway36	9.3	AHR, AHRR, ARNT
9	Transcription Androgen Receptor nuclear signaling10	9.3	SRD5A2, AR, SRD5A1

Compounds related to micropenis according to GeneDecks:

(show top 50)    (show all 137)

id	Compound	Score	Top Affiliating Genes
1	dutasteride32 9 9	11.9	SRD5A2, SRD5A1, AR
2	goserelin32 9 9	11.7	CGA, LHCGR, GNRH1, SRD5A1
3	exemestane32 34 9 9	12.6	AR, SRD5A1, IGFBP3
4	17-hydroxypregnenolone32	9.6	CGA, CGB5, CYP17A1
5	estradiol benzoate32	9.5	CGB5, GNRH1, CGA
6	finasteride32 42 9 18 9	13.5	SRD5A2, SRD5A1, IGFBP3, AR
7	steroidal32	9.5	AR, GNRH1, CYP17A1, SRD5A1
8	dihydroprogesterone32	9.4	SRD5A1, CGB5, CGA
9	cetrorelix32 9 9	11.4	CGB5, GNRH1, LHCGR, CGA
10	leuprolide acetate32	9.4	GNRH1, CGB5, CGA, LHCGR
11	progestins32	9.3	SRD5A1, AR, GNRH1, IGFBP3
12	hydroxyflutamide32	9.2	CGA, AR, SRD5A1
13	clomiphene citrate32	9.2	GNRH1, CGB5, CGA, IGFBP3
14	22r-hydroxycholesterol32	9.1	CGB5, CGA, NR5A1
15	17-hydroxyprogesterone32 18	10.1	CGA, CGB5, GNRH1, CYP17A1, SRD5A1
16	(+-)-pgf2-alpha32	9.1	GNRH1, CGB5, CGA, NR5A1
17	flutamide32 9 9	11.1	AHR, CGA, AR, GNRH1, SRD5A1, LHCGR
18	leuprolide32 42 9 9	12.1	CGA, CGB5, AR, GNRH1, SRD5A1
19	buserelin32 9 9	11.0	CGB5, LHCGR, IGFBP3, GNRH1, CGA
20	prostaglandin f2alpha32	9.0	LHCGR, CGA, IGFBP3, GNRH1, CGB5
21	vitamin a32 9 18 9	11.7	CYP17A1, CGA, CGB5, AR, IGFBP3
22	glutamine32	8.6	AHR, IGFBP3, SRD5A2, SRD5A1, ARNT, AR
23	diethylstilbestrol32 9 9	10.5	CYP17A1, CGB5, AR, NR5A1, GNRH1, CGA
24	dhea32	8.5	NR5A1, CYP17A1, AR, CGB5, IGFBP3, SRD5A1
25	acth32	8.5	NR5A1, GNRH1, IGFBP3, CGB5, LHCGR, CYP17A1
26	actinomycin d32	8.4	GNRH1, AHR, NR5A1, AR, CGB5, CGA
27	17beta-hydroxysteroid32	8.3	AR, CGA, CGB5, CYP17A1, SRD5A1, SRD5A2
28	tamoxifen32 34 9 9	11.3	GNRH1, CYP17A1, IGFBP3, AHR, CGA, AR
29	gnrh32	8.3	NR5A1, CYP17A1, SRD5A1, CGB5, AR, LHCGR
30	dexamethasone32 42 34 9 9	12.2	AHR, SRD5A1, CYP17A1, GNRH1, IGFBP3, AR
31	alanine32	8.2	LHCGR, AHR, SRD5A2, GNRH1, CGA, ARNT
32	vitamin d32	8.1	CGA, IGFBP3, SRD5A2, SRD5A1, AHR, AR
33	androstenedione32 18	9.1	CGB5, CGA, SRD5A2, AR, IGFBP3, GNRH1
34	pge232	8.1	CGA, CGB5, AR, IGFBP3, NR5A1, AHR
35	3beta-hydroxysteroid32	8.1	SRD5A2, SRD5A1, CYP17A1, LHCGR, CGA, CGB5
36	dihydrotestosterone32 9 18 9	11.1	SRD5A1, CGA, SRD5A2, CYP17A1, GNRH1, IGFBP3
37	cycloheximide32	8.0	CYP17A1, NR5A1, IGFBP3, CGB5, AR, AHR
38	ribonucleic acid32	8.0	SRD5A2, CYP17A1, GNRH1, IGFBP3, CGA, CGB5
39	estrone32 9 18 9	10.9	AHR, NR5A1, SRD5A1, CYP17A1, GNRH1, IGFBP3
40	dehydroepiandrosterone sulfate32	7.9	NR5A1, AR, CGB5, CGA, SRD5A1, CYP17A1
41	progestin32	7.9	AHR, SRD5A1, CYP17A1, GNRH1, IGFBP3, AR
42	adenylate32	7.8	AHR, LHCGR, GNRH1, IGFBP3, NR5A1, CGB5
43	vegf32	7.7	AHR, SRD5A1, CGA, IGFBP3, AR, ARNT
44	retinoic acid32 42 18	9.3	GNRH1, AHR, CYP17A1, SRD5A1, NR5A1, IGFBP3
45	progesterone32 42 9 18 9	11.3	CGB5, SRD5A1, CGA, IGFBP3, LHCGR, AR
46	estradiol32 9 18 9	10.1	CYP17A1, GNRH1, IGFBP3, AR, CGB5, CGA
47	testosterone32 9 18 9	10.1	LHCGR, CGA, CGB5, AR, IGFBP3, SRD5A2
48	steroid32	7.1	SRD5A1, CYP17A1, GNRH1, IGFBP3, AR, CGB5
49	arginine32	7.0	AR, CGB5, CGA, IGFBP3, LHCGR, GNRH1
50	estrogen32	6.6	LHCGR, CGA, CGB5, ARNT, AR, IGFBP3

Biological processes related to micropenis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to gonadotropin stimulus	GO:071371	10.1	LHCGR, CYP17A1
2	response to fungicide	GO:060992	10.0	SRD5A1, CYP17A1
3	positive regulation of hormone biosynthetic process	GO:046886	10.0	LHCGR, ARNT
4	male genitalia development	GO:030539	10.0	SRD5A1, LHCGR
5	prostate gland development	GO:030850	10.0	AR, AHR
6	androgen biosynthetic process	GO:006702	9.9	CYP17A1, SRD5A1, SRD5A2
7	steroid metabolic process	GO:008202	9.8	SRD5A2, SRD5A1, CYP17A1
8	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.8	AR, IGFBP3
9	intracellular receptor mediated signaling pathway	GO:030522	9.5	NR5A1, AHR, AR
10	sex differentiation	GO:007548	9.5	CYP17A1, AR
11	male gonad development	GO:008584	9.1	SRD5A1, AR, LHCGR, SRD5A2, NR5A1
12	cell differentiation	GO:030154	9.0	NR5A1, ARNT, SRD5A1, SRD5A2
13	cell-cell signaling	GO:007267	8.9	SRD5A2, NR5A1, GNRH1, AR, CGA
14	small molecule metabolic process	GO:044281	8.2	SRD5A2, INPP5E, SRD5A1, CYP17A1, EXT2, CGA

Molecular functions related to micropenis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	progesterone 5-alpha-reductase activity	GO:050213	9.9	SRD5A1, SRD5A2
2	3-oxo-5-alpha-steroid 4-dehydrogenase activity	GO:003865	9.7	SRD5A2, SRD5A1
3	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.3	AR, AHR, NR5A1
4	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.2	AHR, NR5A1, ARNT