MCID: MCR191
MIFTS: 46

Microscopic Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 14
Colitis, Microscopic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060182
MeSH 42 D046728
NCIt 47 C38504
SNOMED-CT 64 235753003
UMLS 69 C0400821

Summaries for Microscopic Colitis

Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to hypereosinophilic syndrome and lymphocytic colitis. An important gene associated with Microscopic Colitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related phenotypes are Decreased viability and cellular

Wikipedia : 72 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
id Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 29.7 HLA-DRB1 IFNG
2 lymphocytic colitis 26.8 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
3 collagenous colitis 11.8
4 migraine with brainstem aura 10.8 HLA-DRB1 TNF
5 colitis 10.7
6 unilateral hypoactive labyrinth 10.7 CD79A LYZ
7 scirrhous adenocarcinoma 10.7 IL2 TNF
8 acute ackee fruit intoxication 10.6 IL4 TNF
9 fallopian tube carcinoma 10.6 CD79A IL2
10 diabetic angiopathy 10.6 CD79A IL4
11 basidiobolomycosis 10.6 IL4 TNF
12 lagophthalmos 10.6 IL4 TNF
13 immune-complex glomerulonephritis 10.6 CD79A LYZ
14 aniseikonia 10.6 CD79A IL4
15 polyneuropathy due to drug 10.6 CD79A IL4
16 moved to 244450 10.6 HLA-DRB1 TNF
17 cutaneous ganglioneuroma 10.5 CD79A IL4
18 smarca4-deficient sarcoma of thorax 10.5 IL6 TNF
19 tetanus 10.5 LYZ TNF
20 kernicterus due to isoimmunization 10.5 HLA-DRB1 TNF
21 aortic arch interruption 10.5 IL6 TNF
22 urethral intrinsic sphincter deficiency 10.5 IL4 TNF
23 cutaneous leishmaniasis 10.5 IL6 TNF
24 liver leiomyoma 10.5 IL4 TNF
25 visual snow syndrome 10.5 IL2 IL4
26 generalized atherosclerosis 10.5 CD79A IL6
27 hypoparathyroidism, x-linked 10.5 CD79A IL4
28 toxoplasmosis 10.5 IL6 TNF
29 dyslexia 5 10.5 IL6 TNF
30 apple allergy 10.5 CD79A IL4
31 scrotal carcinoma 10.5 IL6 TNF
32 antigen-peptide-transporter 2 deficiency 10.5 IL6 TNF
33 malignant renovascular hypertension 10.4 CD79A IFNG
34 papilledema 10.4 IL6 TNF
35 ethmoid sinus adenocarcinoma 10.4 IL6 TNF
36 uveitis 10.4 CD79A LYZ TNF
37 discitis 10.4 CD79A LYZ TNF
38 sternal cleft 10.4 IFNG TNF
39 pmm2-congenital disorder of glycosylation 10.4 IL2 IL4
40 multiple sclerosis 5 10.4 LYZ TNF
41 not otherwise specified 3-mga-uria type 10.4 HLA-DRB1 TNF
42 hemangioma of orbit 10.4 CD79A IL2 TNF
43 solitary plasmacytoma of chest wall 10.4 IL2 IL6
44 dioctophymiasis 10.4 IL2 IL4
45 dumping syndrome 10.4 CD79A IFNG
46 endogenous depression 10.4 HLA-DRB1 IL2 TNF
47 primary systemic mycosis 10.4 IFNG TNF
48 riboflavin transporter deficiency 10.4 HLA-DRB1 TNF
49 upper gum cancer 10.4 IL6 TNF
50 x-linked dominant intellectual disability-epilepsy syndrome 10.4 IL2 IL6

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis

Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 CD79A HLA-DQB1 SLC6A4
2 Decreased viability GR00381-A-3 9.1 CD79A HLA-DQB1 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
2 hematopoietic system MP:0005397 10.11 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
3 homeostasis/metabolism MP:0005376 10.09 SLC6A4 TNF CD79A HLA-DQB1 IFNG IL2
4 endocrine/exocrine gland MP:0005379 10.08 HLA-DQB1 IFNG IL2 IL4 IL6 LYZ
5 cardiovascular system MP:0005385 10.07 HLA-DQB1 IFNG IL2 IL6 LYZ SLC6A4
6 immune system MP:0005387 10.06 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
7 digestive/alimentary MP:0005381 10.04 HLA-DQB1 IFNG IL2 IL4 IL6 LYZ
8 liver/biliary system MP:0005370 9.97 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
9 nervous system MP:0003631 9.86 CD79A HLA-DQB1 IFNG IL4 IL6 LYZ
10 neoplasm MP:0002006 9.8 IL2 IL6 LYZ TNF CD79A IFNG
11 no phenotypic analysis MP:0003012 9.63 CD79A IFNG IL2 IL4 LYZ TNF
12 renal/urinary system MP:0005367 9.43 CD79A HLA-DQB1 IFNG IL4 IL6 LYZ
13 respiratory system MP:0005388 9.17 HLA-DQB1 IFNG IL2 IL4 IL6 LYZ

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Antirheumatic Agents Phase 4,Phase 2,Phase 3
3 Dermatologic Agents Phase 4
4 Gastrointestinal Agents Phase 4
5
Budesonide Approved Phase 3 51333-22-3 63006 5281004
6 Analgesics Phase 2, Phase 3
7 Analgesics, Non-Narcotic Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
10 Mesalamine Phase 2, Phase 3 89-57-6
11 Peripheral Nervous System Agents Phase 2, Phase 3
12 Anti-Asthmatic Agents Phase 3
13 Autonomic Agents Phase 3
14 Bronchodilator Agents Phase 3
15 glucocorticoids Phase 3
16 Hormone Antagonists Phase 3
17 Hormones Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
19 Respiratory System Agents Phase 3
20
Adalimumab Approved 331731-18-1 16219006
21
Methylene blue Investigational 61-73-4
22 Pharmaceutical Solutions
23 Tolonium Chloride
24 Antacids
25 Anti-Ulcer Agents
26
Bismuth 7440-69-9 16682734 105143
27 Cola Nutraceutical

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative Colitis Completed NCT01408810 Phase 4 Infliximab
2 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
3 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
4 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
5 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
6 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048
7 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
8 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Unknown status NCT02284802
9 The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease Unknown status NCT02481687
10 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
11 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132
12 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514
13 Endocytoscopy for in Vivo Determination of Mucosal Inflammatory Cells and Intestinal Disease Activity in Inflammatory Bowel Disease (IBD) Completed NCT01289366
14 Risk Factors for Microscopic Colitis Recruiting NCT02699333
15 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
16 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709
17 Confocal Laser Endomicroscopy for Assessment of Mucosal Healing in Ulcerative Colitis Recruiting NCT02676817
18 Utilization of NBi in Assessing Luminal INflammaion in IBD (UNBLIND) Recruiting NCT02049775
19 OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages Recruiting NCT02523118
20 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Enrolling by invitation NCT03275467
21 Treatment of Microscopic Colitis Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

39
Colon, T Cells, Bone, Small Intestine, Thyroid

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 326)
id Title Authors Year
1
Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. ( 28498152 )
2017
2
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )
2017
3
Current Approach to the Evaluation and Management of Microscopic Colitis. ( 28265892 )
2017
4
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )
2017
5
Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis? ( 28776143 )
2017
6
Endoscopic features of microscopic colitis: The "grid-like" pattern detected with HD+ colonoscopy plus i-scan. ( 28174001 )
2017
7
Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )
2017
8
Letter: the definition of budesonide dependence in microscopic colitis-authors' reply. ( 28805323 )
2017
9
Extended-release Multimatrix Budesonide for Microscopic Colitis. ( 28328627 )
2017
10
Over 90% of cases of Microscopic Colitis can be diagnosed by performing a short colonoscopy. ( 28215538 )
2017
11
Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case-Control Study. ( 28471835 )
2017
12
Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318707 )
2017
13
Immune modulator therapy for microscopic colitis in a case series of 73 patients. ( 28488312 )
2017
14
Diagnosis and Management of Microscopic Colitis. ( 27897155 )
2017
15
Microscopic colitis: a missed diagnosis among patients with moderate to severe irritable bowel syndrome. ( 27796144 )
2017
16
Letter: the definition of budesonide dependence in microscopic colitis. ( 28805319 )
2017
17
Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis. ( 28070826 )
2017
18
Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )
2017
19
Antidepressant-Associated Microscopic Colitis: A Case Report and Literature Review. ( 28347506 )
2017
20
Macroscopic findings, incidence and characteristics of microscopic colitis in a large cohort of patients from the United Kingdom. ( 28562114 )
2017
21
Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria. ( 28597107 )
2017
22
Family history, comorbidity, smoking and other risk factors in microscopic colitis: a case-control study. ( 28350750 )
2017
23
Biomarkers and Microscopic Colitis: An Unmet Need in Clinical Practice. ( 28540290 )
2017
24
Microscopic Colitis After Fecal Microbiota Transplant. ( 28761890 )
2017
25
Answer to Carmona R.: Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318705 )
2017
26
Validation of a Scoring System to Predict Microscopic Colitis in a Cohort of Patients With Chronic Diarrhea. ( 26687916 )
2016
27
High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. ( 26956016 )
2016
28
American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis. ( 26584605 )
2016
29
Microscopic colitis in patients with Takayasu's arteritis: a potential association between the two disease entities. ( 26742755 )
2016
30
Current concepts on microscopic colitis: evidence-based statements and recommendations of the Spanish Microscopic Colitis Group. ( 26597122 )
2016
31
Towards a new paradigm of microscopic colitis: Incomplete and variant forms. ( 27784958 )
2016
32
Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis. ( 28119938 )
2016
33
Editorial: additional evidence for drug-induced microscopic colitis. ( 27166985 )
2016
34
Editorial: additional evidence for drug-induced microscopic colitis - authors' reply. ( 27166986 )
2016
35
Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27733667 )
2016
36
Shedding light on the dark side of microscopic colitis. ( 27241139 )
2016
37
Managing Microscopic Colitis: A Patient Guide. ( 26584603 )
2016
38
Comment: Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27903770 )
2016
39
The association between the intake of specific dietary components and lifestyle factors and microscopic colitis. ( 27460269 )
2016
40
Development of a Microscopic Colitis Disease Activity Index: a prospective cohort study. ( 27965284 )
2016
41
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. ( 26679722 )
2016
42
Prevalence and Natural History of Microscopic Colitis: A Population-Based Study With Long-term Clinical Follow-up in Terrassa, Spain. ( 26818762 )
2016
43
American Gastroenterological Association Institute Technical Review on the Medical Management of Microscopic Colitis. ( 26584602 )
2016
44
Distinguishing Microscopic Colitis From Irritable Bowel Syndrome. ( 26707680 )
2016
45
New-Onset Microscopic Colitis in an Ulcerative Colitis Patient After Fecal Microbiota Transplantation. ( 27151129 )
2016
46
Reply: Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27903771 )
2016
47
Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functional bowel disorders. ( 26913568 )
2016
48
Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome. ( 27147826 )
2016
49
AGA Institute Guideline on the Management of Microscopic Colitis: Clinical Decision Support Tool. ( 26615117 )
2016
50
Diagnosis and treatment of microscopic colitis. ( 27271790 )
2016

Variations for Microscopic Colitis

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
2
Show member pathways
13.29 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
3
Show member pathways
13.14 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
4
Show member pathways
12.79 IFNG IL2 IL6 TNF
5
Show member pathways
12.72 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
6
Show member pathways
12.71 IL2 IL4 IL6 TNF
7
Show member pathways
12.64 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
8
Show member pathways
12.54 IFNG IL2 IL6 TNF
9 12.52 CD79A IFNG IL2 IL4 TNF
10
Show member pathways
12.48 IFNG IL2 IL4 TNF
11
Show member pathways
12.41 IFNG IL2 IL4 IL6 TNF
12 12.4 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
13
Show member pathways
12.36 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
14
Show member pathways
12.32 IFNG IL4 IL6 TNF
15
Show member pathways
12.24 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
16
Show member pathways
12.21 HLA-DQB1 HLA-DRB1 IFNG IL4 TNF
17
Show member pathways
12.2 IFNG IL2 IL4 IL6
18
Show member pathways
12.19 IFNG IL6 TNF
19
Show member pathways
12.17 IFNG IL4 IL6 TNF
20 12.17 HLA-DQB1 HLA-DRB1 IFNG IL6 TNF
21 12.12 IFNG IL6 TNF
22 12.11 IL6 SLC6A4 TNF
23
Show member pathways
12.1 IFNG IL2 IL4 IL6 TNF
24
Show member pathways
11.97 HLA-DRB1 IFNG IL2 IL4
25 11.95 IFNG IL2 IL4 IL6 TNF
26 11.94 IL4 IL6 TNF
27
Show member pathways
11.94 IFNG IL2 IL6 TNF
28
Show member pathways
11.88 IFNG IL4 IL6
29 11.86 IFNG IL6 TNF
30 11.83 IFNG IL2 IL6
31 11.8 IFNG IL2 IL4 IL6
32 11.78 IFNG IL2 IL4 TNF
33
Show member pathways
11.75 IFNG IL2 IL4 TNF
34 11.75 HLA-DQB1 HLA-DRB1 IL4 IL6 TNF
35 11.74 IFNG IL2 IL6 TNF
36 11.71 IL4 IL6 TNF
37 11.67 HLA-DQB1 HLA-DRB1 IFNG IL6 TNF
38 11.66 IL4 IL6 TNF
39
Show member pathways
11.65 IFNG IL2 TNF
40
Show member pathways
11.65 IFNG IL2 IL6 TNF
41 11.55 IL4 IL6 TNF
42 11.54 IFNG IL6 TNF
43 11.53 IFNG IL2 TNF
44 11.52 IFNG IL2 IL6 TNF
45 11.51 IFNG IL2 IL4
46 11.5 CD79A IFNG IL2 IL4 IL6 TNF
47 11.49 IFNG IL6 TNF
48
Show member pathways
11.43 IFNG IL2 TNF
49 11.37 IFNG IL6 TNF
50 11.34 IFNG IL2 IL4

GO Terms for Microscopic Colitis

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 IFNG IL2 IL4 IL6 LYZ TNF
2 extracellular region GO:0005576 9.5 IFNG IL2 IL4 IL6 LYZ MR1
3 MHC class II protein complex GO:0042613 9.16 HLA-DQB1 HLA-DRB1
4 external side of plasma membrane GO:0009897 9.1 CD79A HLA-DRB1 IFNG IL4 IL6 TNF

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 CD79A HLA-DRB1 IL2 MR1
2 positive regulation of gene expression GO:0010628 9.94 IFNG IL6 SLC6A4 TNF
3 response to drug GO:0042493 9.92 IFNG IL4 IL6 SLC6A4
4 T cell receptor signaling pathway GO:0050852 9.84 HLA-DQB1 HLA-DRB1 IFNG
5 cellular response to lipopolysaccharide GO:0071222 9.83 IFNG IL6 TNF
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.81 IL4 IL6 TNF
7 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-DQB1 HLA-DRB1 IFNG
8 humoral immune response GO:0006959 9.73 IFNG IL6 TNF
9 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL2 IL4 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 IFNG IL6 TNF
11 antigen processing and presentation GO:0019882 9.69 HLA-DQB1 HLA-DRB1 IFNG
12 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
13 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
14 positive regulation of T cell differentiation GO:0045582 9.66 IL2 IL4
15 positive regulation of chemokine production GO:0032722 9.66 IL6 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.65 IFNG TNF
18 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.64 HLA-DQB1 HLA-DRB1
19 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL6
20 positive regulation of protein import into nucleus, translocation GO:0033160 9.62 IFNG IL6
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 IFNG IL2 IL4 IL6
22 defense response to Gram-positive bacterium GO:0050830 9.61 IL6 TNF
23 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
24 defense response to Gram-negative bacterium GO:0050829 9.6 IL6 MR1
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IFNG IL4
26 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
27 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.57 HLA-DQB1 HLA-DRB1
28 positive regulation of T cell proliferation GO:0042102 9.56 IFNG IL2 IL4 IL6
29 negative regulation of T-helper 17 cell differentiation GO:2000320 9.55 IL2 IL4
30 positive regulation of mononuclear cell migration GO:0071677 9.54 IL4 TNF
31 defense response to protozoan GO:0042832 9.54 IFNG IL4 IL6
32 neutrophil apoptotic process GO:0001781 9.49 IFNG IL6
33 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.48 HLA-DQB1 HLA-DRB1
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IFNG TNF
35 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
36 positive regulation of isotype switching to IgG isotypes GO:0048304 9.33 IFNG IL2 IL4
37 immune response GO:0006955 9.23 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
38 positive regulation of chemokine biosynthetic process GO:0045080 9.13 IFNG IL4 TNF

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.02 IFNG IL2 IL4 IL6 TNF
3 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1

Sources for Microscopic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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