MCID: MCR191
MIFTS: 47

Microscopic Colitis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Microscopic Colitis

Aliases & Descriptions for Microscopic Colitis:

Name: Microscopic Colitis 12 14
Colitis, Microscopic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060182
MeSH 42 D046728
NCIt 47 C38504
SNOMED-CT 64 235753003
UMLS 69 C0400821

Summaries for Microscopic Colitis

Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to collagenous colitis and pyoderma gangrenosum. An important gene associated with Microscopic Colitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Wikipedia : 71 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
id Related Disease Score Top Affiliating Genes
1 collagenous colitis 32.1 CD79A IFNG IL2 IL4 IL6 TNF
2 pyoderma gangrenosum 29.2 IFNG IL6 TNF
3 gastroduodenitis 28.9 IFNG IL2 IL4 IL6
4 lymphocytic colitis 11.4
5 colitis 10.7
6 mirizzi syndrome 10.3 HLA-DRB1 TNF
7 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
8 tubular renal disease-cardiomyopathy syndrome 10.2 IL4 TNF
9 dyslexia 5 10.2 IL6 TNF
10 aortic atherosclerosis 10.2 IL6 TNF
11 degenerative disc disease 10.2 IL6 TNF
12 lagophthalmos 10.2 IL4 TNF
13 generalized atherosclerosis 10.2 CD79A IL6
14 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
15 steatitis 10.2 IL2 TNF
16 diabetic angiopathy 10.2 CD79A IL4
17 drug dependence 10.2 IL6 TNF
18 conidiobolomycosis 10.2 IL4 TNF
19 transient tic disorder 10.2 IL6 TNF
20 anal paget's disease 10.2 IL6 TNF
21 malignant renovascular hypertension 10.2 CD79A IFNG
22 swine influenza 10.2 HLA-DRB1 IL6 TNF
23 psychotic disorder 10.2 IL4 IL6
24 vestibule of mouth cancer 10.2 IL4 TNF
25 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HLA-DRB1 IL6 TNF
26 human immunodeficiency virus infectious disease 10.2 HLA-DRB1 IL6 TNF
27 papilledema 10.2 IL6 TNF
28 motility-related diarrhea 10.2 HLA-DRB1 IL6 TNF
29 dextrocardia 10.2 CD79A IL6 TNF
30 sarcoma 10.2 IL2 IL4
31 stocco dos santos syndrome 10.2 IFNG TNF
32 childhood pleomorphic rhabdomyosarcoma 10.2 CD79A IL6 TNF
33 diarrhea 10.2
34 immunoglobulin g deficiency 10.2 HLA-DRB1 IL6 TNF
35 vulvar vestibulitis syndrome 10.2 IL2 IL4
36 retinal vascular disease 10.2 IL4 IL6
37 bladder sarcoma 10.1 CD79A IL6 TNF
38 acute allergic sanguinous otitis media 10.1 IL2 IL6
39 bacterial meningitis 10.1 HLA-DRB1 IL6 TNF
40 paranasal sinus sarcoma 10.1 CD79A IL6 TNF
41 myoglobinuria recurrent 10.1 IFNG IL4
42 stenosis of lacrimal sac 10.1 CD79A IL6 TNF
43 peripheral artery disease 10.1 HLA-DRB1 IL4 TNF
44 familial nephrotic syndrome 10.1 CD79A IL6 TNF
45 nephropathy with pretibial epidermolysis bullosa and deafness 10.1 CD79A IL6 TNF
46 acquired polycythemia 10.1 CD79A IL4 TNF
47 calcinosis 10.1 CD79A IL6 TNF
48 histiocytosis 10.1 CD79A IL6 TNF
49 asymptomatic neurosyphilis 10.1 IFNG IL4
50 xanthogranulomatous cholecystitis 10.1 CD79A IL4 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis

Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.5 IL4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.5 SLC6A4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.5 CD79A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.5 IL4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.5 SLC6A4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.5 IL4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.5 SLC6A4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.5 IL4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 CD79A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.5 IL4 SLC6A4 CD79A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 CD79A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.5 SLC6A4
14 Decreased viability GR00381-A-1 9.43 CD79A HLA-DQB1 SLC6A4
15 Decreased viability GR00381-A-3 9.43 CD79A HLA-DQB1 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IL4 IL6 MR1 TNF CD79A HLA-DQB1
2 endocrine/exocrine gland MP:0005379 9.95 HLA-DQB1 IFNG IL2 IL4 IL6 SLC6A4
3 homeostasis/metabolism MP:0005376 9.92 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
4 digestive/alimentary MP:0005381 9.91 IL6 TNF HLA-DQB1 IFNG IL2 IL4
5 immune system MP:0005387 9.86 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
6 liver/biliary system MP:0005370 9.7 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
7 neoplasm MP:0002006 9.35 CD79A IFNG IL2 IL6 TNF
8 respiratory system MP:0005388 9.1 HLA-DQB1 IFNG IL2 IL4 IL6 TNF

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Antirheumatic Agents Phase 4,Phase 2,Phase 3
3 Dermatologic Agents Phase 4
4 Gastrointestinal Agents Phase 4
5
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
6 Anti-Asthmatic Agents Phase 3,Phase 2
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Autonomic Agents Phase 3,Phase 2
9 Bronchodilator Agents Phase 3,Phase 2
10 glucocorticoids Phase 3,Phase 2
11 Hormone Antagonists Phase 3,Phase 2
12 Hormones Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3,Phase 2
15 Respiratory System Agents Phase 3,Phase 2
16 Analgesics Phase 2, Phase 3
17 Analgesics, Non-Narcotic Phase 2, Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
19 Mesalamine Phase 2, Phase 3 89-57-6
20
Glatiramer Acetate Approved, Investigational Phase 2 147245-92-9 3081884
21 Adjuvants, Immunologic Phase 2
22 Immunosuppressive Agents Phase 2
23
Adalimumab Approved 331731-18-1 16219006
24
Inulin Approved, Nutraceutical 9005-80-5 24763
25
Methylene blue Investigational 61-73-4
26 Tolonium Chloride
27 Pharmaceutical Solutions
28
Levan 9013-95-0 22833608
29 Antacids
30 Anti-Ulcer Agents
31
Bismuth 7440-69-9 16682734 105143
32 Cola Nutraceutical
33 Chicory Nutraceutical

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative Colitis Completed NCT01408810 Phase 4
2 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3
3 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3
4 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3
5 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3
6 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3
7 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3
8 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3
9 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Recruiting NCT01209208 Phase 3
10 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3
11 A Double Blind Placebo Control Study to Assess the Safety,Tolerability and Efficacy of Copaxone in Crohn's Disease Unknown status NCT00731172 Phase 2
12 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
13 The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease Unknown status NCT02481687
14 Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer Unknown status NCT01075893
15 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
16 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132
17 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514
18 Endocytoscopy for in Vivo Determination of Mucosal Inflammatory Cells and Intestinal Disease Activity in Inflammatory Bowel Disease (IBD) Completed NCT01289366
19 Risk Factors for Microscopic Colitis Recruiting NCT02699333
20 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
21 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Recruiting NCT01504048
22 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Recruiting NCT02284802
23 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709
24 Confocal Laser Endomicroscopy for Assessment of Mucosal Healing in Ulcerative Colitis Recruiting NCT02676817
25 Utilization of NBi in Assessing Luminal INflammaion in IBD (UNBLIND) Recruiting NCT02049775
26 OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages Recruiting NCT02523118
27 Ulcerative Colitis Relapse Prevention by Prebiotics Recruiting NCT02865707
28 Treatment of Microscopic Colitis Terminated NCT00184171

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

39
Colon, T Cells, Bone, Thyroid, Small Intestine

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 305)
id Title Authors Year
1
Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )
2017
2
Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis. ( 28070826 )
2017
3
Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )
2017
4
Diagnosis and Management of Microscopic Colitis. ( 27897155 )
2017
5
Microscopic colitis: a missed diagnosis among patients with moderate to severe irritable bowel syndrome. ( 27796144 )
2017
6
Diagnosis and treatment of microscopic colitis. ( 27271790 )
2016
7
Prevalence and Natural History of Microscopic Colitis: A Population-Based Study With Long-term Clinical Follow-up in Terrassa, Spain. ( 26818762 )
2016
8
Differences in the socio-economic distribution of inflammatory bowel disease and microscopic colitis. ( 27166978 )
2016
9
Current concepts on microscopic colitis: evidence-based statements and recommendations of the Spanish Microscopic Colitis Group. ( 26597122 )
2016
10
American Gastroenterological Association Institute Technical Review on the Medical Management of Microscopic Colitis. ( 26584602 )
2016
11
Validation of a Scoring System to Predict Microscopic Colitis in a Cohort of Patients With Chronic Diarrhea. ( 26687916 )
2016
12
Comment: Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27903770 )
2016
13
Towards a new paradigm of microscopic colitis: Incomplete and variant forms. ( 27784958 )
2016
14
Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functional bowel disorders. ( 26913568 )
2016
15
Development of a Microscopic Colitis Disease Activity Index: a prospective cohort study. ( 27965284 )
2016
16
Validation and modification of a diagnostic scoring system to predict microscopic colitis. ( 27243102 )
2016
17
Microscopic colitis in patients with Takayasu's arteritis: a potential association between the two disease entities. ( 26742755 )
2016
18
Editorial: additional evidence for drug-induced microscopic colitis - authors' reply. ( 27166986 )
2016
19
High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. ( 26956016 )
2016
20
Successful use of adalimumab in patient with treatment-refractory microscopic colitis. ( 27530873 )
2016
21
Editorial: additional evidence for drug-induced microscopic colitis. ( 27166985 )
2016
22
Optimization of a Scoring System to Predict Microscopic Colitis in a Cohort of Patients With Chronic Diarrhea. ( 27404403 )
2016
23
New-Onset Microscopic Colitis in an Ulcerative Colitis Patient After Fecal Microbiota Transplantation. ( 27151129 )
2016
24
On Inverse Association Between Helicobacter pylori Gastritis and Microscopic Colitis: The European Data. ( 26871398 )
2016
25
Managing Microscopic Colitis: A Patient Guide. ( 26584603 )
2016
26
Shedding light on the dark side of microscopic colitis. ( 27241139 )
2016
27
Microscopic colitis in patients with mild duodenal damage: A new clinical and pathological entity ("lymphocytic enterocolitis")? ( 27895976 )
2016
28
American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis. ( 26584605 )
2016
29
The association between the intake of specific dietary components and lifestyle factors and microscopic colitis. ( 27460269 )
2016
30
Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome. ( 27147826 )
2016
31
Microscopic colitis: A literature review. ( 28001266 )
2016
32
Incidence, Clinical Presentation, and Associated Factors of Microscopic Colitis in Northern France: A Population-Based Study. ( 27659673 )
2016
33
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. ( 26679722 )
2016
34
AGA Institute Guideline on the Management of Microscopic Colitis: Clinical Decision Support Tool. ( 26615117 )
2016
35
Reply: Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27903771 )
2016
36
Association Between Proton Pump Inhibitors and Microscopic Colitis: Implications for Practice and Future Research. ( 27733667 )
2016
37
Distinguishing Microscopic Colitis From Irritable Bowel Syndrome. ( 26707680 )
2016
38
Incidence, prevalence, and temporal trends of microscopic colitis: a systematic review and meta-analysis. ( 25623658 )
2015
39
Drug consumption and additional risk factors associated with microscopic colitis: Case-control study. ( 26031862 )
2015
40
Microscopic colitis. ( 25925924 )
2015
41
Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly. ( 25933449 )
2015
42
Predicting Microscopic Colitis Before Colon Biopsies: A Look Into the Crystal Ball? ( 25725442 )
2015
43
Microscopic colitis (lymphocytic and collagenous), eosinophilic colitis, and celiac disease. ( 26034409 )
2015
44
Two gastrointestinal conditions with similar symptoms and endoscopic appearance: irritable bowel syndrome and microscopic colitis. ( 26084132 )
2015
45
Microscopic colitis: a misnomer for a clearly defined entity? ( 25961440 )
2015
46
Pyoderma gangrenosum in association with microscopic colitis, idiopathic hypereosinophilic syndrome, selective IgE deficiency and diabetes mellitus. ( 25704069 )
2015
47
VSL#3 induces and maintains short-term clinical response in patients with active microscopic colitis: a two-phase randomised clinical trial. ( 26462271 )
2015
48
Association of Serotonin Transporter Promoter Polymorphism (5-HTTLPR) with Microscopic Colitis and Ulcerative Colitis. ( 25532499 )
2015
49
The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study. ( 25645623 )
2015
50
Inverse Association Between Helicobacter pylori Gastritis and Microscopic Colitis. ( 26383914 )
2015

Variations for Microscopic Colitis

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
2
Show member pathways
13.29 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
3
Show member pathways
13.12 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
4
Show member pathways
12.7 IL2 IL4 IL6 TNF
5
Show member pathways
12.69 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
6
Show member pathways
12.56 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
7
Show member pathways
12.54 IFNG IL2 IL6 TNF
8 12.52 CD79A IFNG IL2 IL4 TNF
9
Show member pathways
12.48 IFNG IL2 IL4 TNF
10
Show member pathways
12.42 IFNG IL2 IL4 IL6 TNF
11 12.41 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
12
Show member pathways
12.36 CD79A HLA-DQB1 HLA-DRB1 IFNG IL2 IL4
13
Show member pathways
12.32 IFNG IL4 IL6 TNF
14
Show member pathways
12.29 IFNG IL2 IL4 IL6 TNF
15
Show member pathways
12.24 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
16
Show member pathways
12.21 HLA-DQB1 HLA-DRB1 IFNG IL4 TNF
17
Show member pathways
12.2 IFNG IL2 IL4 IL6
18
Show member pathways
12.19 IFNG IL6 TNF
19
Show member pathways
12.17 IFNG IL4 IL6 TNF
20 12.17 HLA-DQB1 HLA-DRB1 IFNG IL6 TNF
21 12.12 IFNG IL6 TNF
22 12.11 IL6 SLC6A4 TNF
23
Show member pathways
12.1 IFNG IL2 IL4 IL6 TNF
24
Show member pathways
11.98 HLA-DRB1 IFNG IL2 IL4
25
Show member pathways
11.95 IFNG IL2 IL6 TNF
26 11.95 IFNG IL2 IL4 IL6 TNF
27 11.94 IL4 IL6 TNF
28
Show member pathways
11.89 IFNG IL4 IL6
29 11.86 IFNG IL6 TNF
30 11.82 HLA-DQB1 HLA-DRB1 IL4 IL6 TNF
31 11.81 IFNG IL2 IL4 IL6
32 11.8 IFNG IL2 IL4 TNF
33
Show member pathways
11.76 IFNG IL2 IL4 TNF
34 11.75 IFNG IL2 IL6 TNF
35 11.72 IL4 IL6 TNF
36 11.72 HLA-DQB1 HLA-DRB1 IFNG IL6 TNF
37 11.7 IFNG IL2 IL6
38 11.67 IL4 IL6 TNF
39
Show member pathways
11.65 IFNG IL2 TNF
40
Show member pathways
11.65 IFNG IL2 IL6 TNF
41 11.55 IL4 IL6 TNF
42 11.55 IFNG IL6 TNF
43 11.53 IFNG IL2 TNF
44 11.52 IFNG IL2 IL4
45 11.52 IFNG IL2 IL6 TNF
46 11.5 IFNG IL6 TNF
47 11.5 CD79A IFNG IL2 IL4 IL6 TNF
48
Show member pathways
11.44 IFNG IL2 TNF
49 11.37 IFNG IL6 TNF
50 11.34 IFNG IL2 IL4

GO Terms for Microscopic Colitis

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 CD79A HLA-DRB1 IFNG IL4 IL6 TNF
2 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 IFNG IL2 IL4 IL6
2 immune system process GO:0002376 9.96 CD79A HLA-DRB1 IL2 MR1
3 positive regulation of gene expression GO:0010628 9.91 IFNG IL6 SLC6A4 TNF
4 response to drug GO:0042493 9.91 IFNG IL4 IL6 SLC6A4
5 T cell receptor signaling pathway GO:0050852 9.84 HLA-DQB1 HLA-DRB1 IFNG
6 cellular response to lipopolysaccharide GO:0071222 9.81 IFNG IL6 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.79 IL4 IL6 TNF
8 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-DQB1 HLA-DRB1 IFNG
9 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL2 IL4 TNF
10 humoral immune response GO:0006959 9.73 IFNG IL6 TNF
11 protein import into nucleus, translocation GO:0000060 9.68 IFNG TNF
12 positive regulation of activated T cell proliferation GO:0042104 9.68 IL2 IL4
13 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
15 positive regulation of T cell proliferation GO:0042102 9.67 IFNG IL2 IL4 IL6
16 positive regulation of T cell differentiation GO:0045582 9.66 IL2 IL4
17 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.65 IL2 IL4
18 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
19 negative regulation of growth of symbiont in host GO:0044130 9.65 IFNG TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL6 TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IFNG TNF
22 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.63 HLA-DQB1 HLA-DRB1
23 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL6
24 positive regulation of protein import into nucleus, translocation GO:0033160 9.62 IFNG IL6
25 negative regulation of lipid storage GO:0010888 9.6 IL6 TNF
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IFNG IL4
27 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
28 defense response to protozoan GO:0042832 9.58 IFNG IL4 IL6
29 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.57 HLA-DQB1 HLA-DRB1
30 negative regulation of T-helper 17 cell differentiation GO:2000320 9.55 IL2 IL4
31 positive regulation of mononuclear cell migration GO:0071677 9.54 IL4 TNF
32 neutrophil apoptotic process GO:0001781 9.52 IFNG IL6
33 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.51 HLA-DQB1 HLA-DRB1
34 positive regulation of chemokine biosynthetic process GO:0045080 9.5 IFNG IL4 TNF
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG TNF
36 antigen processing and presentation GO:0019882 9.46 HLA-DQB1 HLA-DRB1 IFNG MR1
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
38 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IFNG IL2 IL4
39 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 IFNG IL2 IL4 IL6
40 immune response GO:0006955 9.23 HLA-DQB1 HLA-DRB1 IFNG IL2 IL4 IL6
41 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.07 IFNG IL2 IL4 IL6 TNF

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.02 IFNG IL2 IL4 IL6 TNF
3 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1

Sources for Microscopic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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