MCID: MCR191
MIFTS: 40

Microscopic Colitis malady

Gastrointestinal diseases category

Summaries for Microscopic Colitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Microscopic colitis refers to two medical conditions which cause diarrhea: collagenous colitis and... more...

MalaCards: Microscopic Colitis, also known as colitis, microscopic, is related to diarrhea and inflammatory bowel disease. An important gene associated with Microscopic Colitis is LYZ (lysozyme), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and pentoxifylline have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Microscopic Colitis

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48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
microscopic colitis:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

microscopic colitis 48
colitis, microscopic 60


External Ids:

MESH via Orphanet35 D046728
ICD10 via Orphanet26 K52.8
SNOMED-CT via Orphanet57 235753003
UMLS via Orphanet61 C0400821

Related Diseases for Microscopic Colitis

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17GeneCards, 18GeneDecks
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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.9IL2, CD79A
2inflammatory bowel disease30.3HLA-DQB1, TNF, IFNG, IL15, IL4, IL6
3celiac disease30.3IL15, CD79A, HLA-DQB1
4collagenous colitis30.3NOS2
5thyroiditis29.9CD79A, HLA-DRB1
6colorectal cancer29.9IL15, IL2
7ulcerative colitis29.9IL6, NOS2, IL4, IL15, CD79A, HLA-DRB1
8irritable bowel syndrome10.4
9syndromic diarrhea10.2
10nephritis10.0CD79A
11pemphigus10.0CD79A
12sjogren's syndrome10.0CD79A
13brucellosis10.0CD79A
14rubella10.0CD79A
15nephrotic syndrome10.0CD79A
16otitis media10.0CD79A
17purpura10.0CD79A
18polymyositis10.0IL15
19measles10.0CD79A
20sinusitis10.0CD79A
21bronchiectasis10.0CD79A
22human immunodeficiency virus infectious disease10.0CD79A
23histiocytosis10.0LYZ
24q fever10.0CD79A
25cryoglobulinemia10.0CD79A
26pemphigus vulgaris10.0HLA-DRB1
27mumps10.0CD79A
28reactive arthritis10.0CD79A
29infertility10.0CD79A
30toxoplasmosis10.0CD79A
31lupus nephritis10.0CD79A
32viral hepatitis10.0HLA-DRB1
33neuropathy10.0CD79A
34liver cirrhosis10.0HLA-DRB1
35lupus erythematosus10.0CD79A
36tonsillitis10.0CD79A
37hypertension10.0CD79A
38typhoid fever10.0CD79A
39herpes simplex10.0CD79A
40autoimmune hemolytic anemia10.0CD79A
41pertussis10.0CD79A
42cholera10.0CD79A
43encephalitis10.0NOS2
44gastrointestinal system disease10.0NOS2
45polymyalgia rheumatica10.0HLA-DRB1
46myocarditis10.0NOS2
47pancreatic cancer10.0IL15
48bronchitis10.0CD79A
49hyperthyroidism10.0HLA-DRB1
50polyneuropathy10.0CD79A

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to microscopic colitis

Clinical Features for Microscopic Colitis

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Drugs & Therapeutics for Microscopic Colitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Microscopic Colitis

Drug clinical trials:

Search ClinicalTrials for Microscopic Colitis

Search NIH Clinical Center for Microscopic Colitis

Search CenterWatch for Microscopic Colitis

Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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Animal Models for Microscopic Colitis or affiliated genes

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36MGI
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Publications for Microscopic Colitis

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Genetic Variations for Microscopic Colitis

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Expression for genes affiliated with Microscopic Colitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for genes affiliated with Microscopic Colitis

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome
See all sources

Pathways related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HLA-DRB1
210.1IL4
3
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10.1IL2
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IFNG
5
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10.0IL6
610.0IL15
7
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10.0IL15
8
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10.0IL15
9
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9.9HLA-DQB1, HLA-DRB1
10
Immune response NFAT in immune response
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9.6HLA-DRB1, HLA-DQB1, CD79A
119.5HLA-DQB1, HLA-DRB1, IL2
12
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9.5HLA-DQB1, HLA-DRB1, IL2
139.4IFNG, HLA-DRB1, IL2
149.3IL4, IFNG, IL2
159.3IL2, IL4, IFNG
169.3IL6, NOS2, IFNG
179.3NOS2, IL6, IFNG
189.2NOS2, TNF, IL6
199.2IL2, IFNG, TNF
209.1TNF, IFNG, IL6
219.1IFNG, TNF, IL6
22
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9.1IFNG, CD79A, IL2, IL4
23
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9.0IL4, IFNG, IL2, HLA-DRB1
24
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9.0TNF, HLA-DQB1, IFNG, HLA-DRB1
259.0IL6, IL15, TNF
268.9IL2, IL6, IL4, IFNG
278.9TNF, IL4, IL6, HLA-DRB1
28
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8.8IL2, IL4, TNF, IFNG
29
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8.8IL2, IL6, CD79A, HLA-DRB1, HLA-DQB1
30
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8.8IFNG, TNF, IL6, NOS2
318.8IL6, NOS2, IFNG, TNF
32
Immune response Bacterial infections in normal airways
8.8NOS2, IL6, TNF, IFNG
33
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8.7IFNG, TNF, IL6, IL2
34
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8.7IL6, IFNG, HLA-DQB1, HLA-DRB1, IL2
35
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8.6TNF, IL2, IL15, IFNG
36
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8.5IL2, IL4, CD79A, TNF, IFNG
378.5IL6, IL2, TNF, NOS2, IL4
38
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8.4IFNG, TNF, IL6, IL2, NOS2
39
Development PDGF signaling via STATs and NF-kB
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8.4TNF, IFNG, NOS2, IL2, IL6
408.4IL6, TNF, IFNG, IL2, NOS2
41
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8.4CD79A, IL6, IL2, HLA-DRB1, IFNG, HLA-DQB1
428.4IFNG, IL4, IL6, IL2, IL15
43
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8.3TNF, IL15, IL6, IL2, IL4
44
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8.3IL2, IL6, IL4, IL15, TNF
458.2NOS2, IFNG, TNF, HLA-DQB1, HLA-DRB1, IL6
468.0IL15, HLA-DRB1, IL6, IL2, TNF, HLA-DQB1
47
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8.0HLA-DRB1, CD79A, IFNG, HLA-DQB1, IL2, IL4
487.8IL4, IL15, TNF, IFNG, IL6, IL2
49
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7.7IL4, IL6, IL15, HLA-DQB1, TNF, HLA-DRB1
50
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7.3IL2, IL6, IL4, IFNG, TNF, HLA-DQB1

Compounds for genes affiliated with Microscopic Colitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1pge24410.5IL2
2pentoxifylline44 1111.5IL4
3prednisolone44 28 1112.5CD79A
4ivig4410.2CD79A, IFNG
5melphalan44 1111.1TNF, CD79A
6gm-csf44 2811.0IFNG, TNF
72,5-oligoadenylate449.9IL2, TNF
8cyclosporin a44 28 5911.6IL15, IFNG, CD79A
9dexamethasone44 49 28 1112.6CD79A, IL6, IL15
10glatiramer acetate44 1110.4IL2, IFNG, IL4, HLA-DRB1
11c-d4t449.4IL15, IL4, IL2
12bucillamine449.4IL2, IL6, CD79A, IFNG
13con a449.4IL4, IL2, IFNG, CD79A
14gold sodium thiomalate449.3TNF, HLA-DRB1, IL2, IFNG
15interferon gamma449.3IL4, IFNG, TNF, IL2
16alpha-galactosylceramide449.2IL15, IL2, IFNG, IL4
17vesnarinone449.2NOS2, IL6, TNF, IFNG
18adalimumab44 49 1111.1TNF, CD79A, IL6, IFNG
19allergens449.1IFNG, HLA-DRB1, IL4, CD79A
20polymyxin b449.1IL4, IFNG, TNF, IL6
21parthenolide44 210.1IFNG, TNF, IL6, NOS2
22blys449.0CD79A, TNF, IL15
23methylcellulose449.0IFNG, IL15, IL4, IL6
24tacrolimus44 49 1110.9IL15, IFNG, CD79A, IL4, IL2
25herbimycin a44 599.9NOS2, IL2, TNF, IFNG, IL4
26mip 1alpha448.9TNF, IL6, IL4
27taurine chloramine448.8TNF, IL6, IL2, NOS2, IFNG
28triptolide448.8IL2, NOS2, IL6, TNF, IFNG
29etanercept44 49 1110.8IFNG, IL6, IL15, TNF
3015-deoxy-delta-12,14-prostaglandin j2448.8IFNG, TNF, IL6, NOS2, IL4
31pdtc448.8IFNG, NOS2, IL6, IL4, TNF
32chloroquine44 2 49 28 1112.8TNF, IL4, IL15, IL2, CD79A
33ccl344 289.7TNF, IL15, IL6, IFNG
34thalidomide44 49 59 1111.7IL2, IL6, TNF, IFNG
35rituximab44 49 1110.7IL15, IL6, CD79A, TNF, IL2
36poly(i-c)448.6TNF, IL4, IFNG, IL15, IL6
37infliximab44 49 1110.6IL6, IL15, TNF, IFNG, IL4
38calcitriol44 59 11 2411.6IL2, IL6, IL4, TNF, IFNG
39ionomycin448.5TNF, IL4, IL2, IFNG, IL15
40neopterin448.5CD79A, IFNG, IL2, IL6, IL4, TNF
41methotrexate44 49 1110.5IL15, IL6, TNF, HLA-DRB1, CD79A
42actinomycin d448.3IFNG, NOS2, IL2, IL6, TNF, IL4
43il-12448.3IL2, IL6, IL15, IFNG, TNF, IL4
44il 10448.3IFNG, IL2, IL6, IL4, IL15, TNF
45rantes448.2IL6, TNF, IL2, IL4, IL15, IFNG
46okt3448.0IL2, IFNG, TNF, CD79A, IL15, IL4
47histamine44 28 2410.0IL6, IL2, IL15, CD79A, TNF, IFNG
48polyinosinic-polycytidylic acid448.0IL6, IFNG, NOS2, IL2, TNF, IL15
49thymidine44 248.9IFNG, TNF, IL2, IL6, IL4, IL15
50vegf447.6IFNG, TNF, IL6, CD79A, IL2, IL4

GO Terms for genes affiliated with Microscopic Colitis

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Sources:
16Gene Ontology
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Cellular components related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.9HLA-DRB1, HLA-DQB1
2external side of plasma membraneGO:0098978.2IL6, IFNG, TNF, HLA-DRB1, CD79A, IL4
3extracellular spaceGO:0056157.5IFNG, IL4, IL6, IL2, LYZ, IL15
4extracellular regionGO:0055767.0LYZ, IFNG, MR1, TNF, IL15, IL6

Biological processes related to Microscopic Colitis according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.2HLA-DQB1, HLA-DRB1
2innate immune response in mucosaGO:00222710.2IL4, NOS2
3humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DRB1, HLA-DQB1
4positive regulation of killing of cells of other organismGO:05171210.1NOS2, IFNG
5positive regulation of MHC class II biosynthetic processGO:04534810.0IFNG, IL4
6neutrophil apoptotic processGO:00178110.0IL6, IFNG
7positive regulation of immunoglobulin secretionGO:0510249.9IL2, IL6
8positive regulation of vitamin D biosynthetic processGO:0605579.9TNF, IFNG
9positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9TNF, IFNG
10positive regulation of tissue remodelingGO:0341059.9IL2, IL15
11interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DQB1, HLA-DRB1, IFNG
12negative regulation of lipid storageGO:0108889.8TNF, IL6
13epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8TNF, IL6
14positive regulation of isotype switching to IgG isotypesGO:0483049.8IFNG, IL2, IL4
15positive regulation of interleukin-17 productionGO:0327409.8IL15, IL2
16positive regulation of activated T cell proliferationGO:0421049.8IL4, IL2
17defense response to protozoanGO:0428329.7IL6, IL4, IFNG
18positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4
20defense response to bacteriumGO:0427429.6LYZ, NOS2, IFNG
21negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF
22positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, IL4, TNF
23positive regulation of chemokine productionGO:0327229.5TNF, IL6
24positive regulation of nitric oxide biosynthetic processGO:0454299.5IFNG, IL6, TNF
25defense response to Gram-negative bacteriumGO:0508299.5MR1, IL6, NOS2
26regulation of insulin secretionGO:0507969.5NOS2, TNF, IFNG
27humoral immune responseGO:0069599.5IFNG, TNF, IL6
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, IL6, IL4
29cytokine-mediated signaling pathwayGO:0192219.4HLA-DQB1, IFNG, IL6, HLA-DRB1
30positive regulation of osteoclast differentiationGO:0456729.2IFNG, TNF
31positive regulation of T cell proliferationGO:0421029.1IL4, IL6, IL15, IFNG
32response to drugGO:0424939.1IL4, TNF, IFNG, IL6
33inflammatory responseGO:0069548.8TNF, LYZ, NOS2, IL6, IL15
34positive regulation of transcription from RNA polymerase II promoterGO:0459448.6TNF, IL2, IFNG, IL6, IL4
35immune responseGO:0069558.5IL4, IL2, HLA-DQB1, MR1, HLA-DRB1, IL15

Molecular functions related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.9HLA-DRB1, HLA-DQB1
2cytokine activityGO:0051257.5IL2, IL6, IL4, IL15, TNF, IFNG

Products for genes affiliated with Microscopic Colitis

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Sources for Microscopic Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet