MCID: MCR191
MIFTS: 46

Microscopic Colitis malady

Gastrointestinal category

Summaries for Microscopic Colitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Microscopic colitis refers to two medical conditions which cause diarrhea: collagenous colitis and... more...

MalaCards: Microscopic Colitis, also known as colitis, microscopic, is related to collagenous colitis and celiac disease. An important gene associated with Microscopic Colitis is LYZ (lysozyme), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and thyroid, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Microscopic Colitis

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
microscopic colitis:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

microscopic colitis 49
colitis, microscopic 61


External Ids:

MESH via Orphanet36 D046728
ICD10 via Orphanet26 K52.8
SNOMED-CT via Orphanet58 235753003
UMLS via Orphanet62 C0400821

Related Diseases for Microscopic Colitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to microscopic colitis

Clinical Features for Microscopic Colitis

Drugs & Therapeutics for Microscopic Colitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Microscopic Colitis

Drug clinical trials:

Search ClinicalTrials for Microscopic Colitis

Search NIH Clinical Center for Microscopic Colitis

Search CenterWatch for Microscopic Colitis

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Microscopic Colitis:

33
Small intestine, Colon, Thyroid, T cells

Animal Models for Microscopic Colitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Microscopic Colitis

Sources:
51PubMed
See all sources

Articles related to Microscopic Colitis:

(show top 50)    (show all 228)
idTitleAuthorsYear
1
Microscopic Colitis - Clinical and Pathologic Perspectives. (24407107)
2014
2
Microscopic colitis: a therapeutic challenge. (23801853)
2013
3
Microscopic colitis. A review. (23419063)
2013
4
Idiopathic microscopic colitis of rhesus macaques: quantitative assessment of colonic mucosa. (23775860)
2013
5
Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis. (23561634)
2013
6
Microscopic colitis with macroscopic endoscopic findings. (23653653)
2013
7
Juvenile spondyloarthritis with microscopic colitis. (22885441)
2012
8
Report from the Falk Workshop on Microscopic Colitis: creating awareness for an underappreciated disease. (23000527)
2012
9
Current and past cigarette smoking significantly increase risk for microscopic colitis. (22147506)
2012
10
Cytokine gene polymorphism in microscopic colitis association with the IL-6-174 GG genotype. (21527852)
2011
11
Gastroduodenal mucosa in microscopic colitis. (21291294)
2011
12
Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study. (21039674)
2010
13
Use of budesonide in the treatment of microscopic colitis. (20616427)
2010
14
Microscopic colitis and Medication Use. (20640056)
2010
15
Microscopic colitis in patients presenting with chronic diarrhea. (20090215)
2010
16
An association between microscopic colitis and celiac disease. (19631283)
2009
17
Microscopic colitis: an update. (19169149)
2009
18
Microscopic colitis: an unfamiliar but treatable disease. (19299845)
2009
19
Diagnosis and management of microscopic colitis. (19109861)
2008
20
Response to clozapine-induced microscopic colitis: a case report and review of the literature. (18626275)
2008
21
Clozapine-induced microscopic colitis: a case report and review of the literature. (18004122)
2007
22
Microscopic colitis demonstrates a T helper cell type 1 mucosal cytokine profile. (16775121)
2007
23
Microscopic colitis: not just for aristocrats. (17565628)
2007
24
Pharmacotherapy for microscopic colitis. (17316153)
2007
25
Microscopic colitis with granuloma which responded to steroid therapy. (17878641)
2007
26
Microscopic colitis: prevalence and distribution throughout the colon in patients with chronic diarrhoea. (15869041)
2005
27
Microscopic colitis: a retrospective study of clinical presentation in 53 patients. (15761974)
2005
28
Microscopic (collagenous and lymphocytic) colitis triggered by food allergy. (15647205)
2005
29
Microscopic colitis syndrome--a review article. (15926644)
2005
30
Predisposing HLA-DQ2 and HLA-DQ8 haplotypes of coeliac disease and associated enteropathy in microscopic colitis. (16292086)
2005
31
A rare variant of microscopic colitis with granulomatous inflammation. (16324207)
2005
32
Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998. (14960513)
2004
33
Diagnosis and management of microscopic colitis syndrome. (15115926)
2004
34
Microscopic colitis: a missed diagnosis? (15582063)
2004
35
Economic comparison of current endoscopic practices: Barrett's surveillance vs. ulcerative colitis surveillance vs. biopsy for sprue vs. biopsy for microscopic colitis. (15628708)
2004
36
Microscopic colitis. (12744549)
2003
37
Prevalence of microscopic colitis in patients with symptoms suggesting irritable bowel syndrome. (12891921)
2003
38
Lansoprazole-associated microscopic colitis: a case series. (12425567)
2002
39
Familial occurrence of microscopic colitis: an opportunity to study the relationship between microscopic colitis and coeliac disease? (12465738)
2002
40
Atypical forms of inflammatory bowel disease: microscopic colitis and pouchitis. (17031099)
2000
41
Lymphocytic venulitis: an unusual association with microscopic colitis. (10474525)
1999
42
Microscopic colitis syndrome: lymphocytic colitis and collagenous colitis. (10548408)
1999
43
Functional asplenia and microscopic (collagenous) colitis. (9113886)
1996
44
Response to treatment of microscopic colitis. (7919463)
1994
45
Collagenous and microscopic colitis: clinical importance. (7936004)
1994
46
Lymphocytic (microscopic) colitis--an important cause of chronic watery diarrhea. (8316318)
1993
47
Microscopic colitis: a diagnosis to consider. (8114249)
1993
48
Microscopic colitis cases revisited. (8224678)
1993
49
Subepithelial collagen table thickness in colon specimens from patients with microscopic colitis and collagenous colitis. (1451972)
1992
50
Microscopic colitis. (2013415)
1991

Genetic Variations for Microscopic Colitis

Expression for genes affiliated with Microscopic Colitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for genes affiliated with Microscopic Colitis

Sources:
38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HLA-DRB1
210.1IL4
3
Hide members
10.1IL2
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IFNG
5
Hide members
10.0IL6
610.0IL15
7
Hide members
10.0IL15
8
Hide members
10.0IL15
9
Hide members
9.9HLA-DRB1, HLA-DQB1
10
Immune response NFAT in immune response
Hide members
9.6HLA-DQB1, HLA-DRB1, CD79A
119.5HLA-DQB1, HLA-DRB1, IL2
12
Hide members
9.5IL2, HLA-DRB1, HLA-DQB1
139.4IL2, HLA-DRB1, IFNG
149.3IFNG, IL4, IL2
159.3IL2, IL4, IFNG
169.3NOS2, IL6, IFNG
179.3NOS2, IL6, IFNG
189.2NOS2, IL6, TNF
199.2IFNG, TNF, IL2
209.1IL6, TNF, IFNG
219.1IL6, TNF, IFNG
22
Hide members
9.1IFNG, CD79A, IL4, IL2
23
Hide members
9.0IL2, IL4, HLA-DRB1, IFNG
24
Hide members
9.0IFNG, TNF, HLA-DQB1, HLA-DRB1
259.0TNF, IL15, IL6
268.9IFNG, IL4, IL6, IL2
278.9TNF, HLA-DRB1, IL4, IL6
28
Hide members
8.8IL2, IL4, TNF, IFNG
29
Hide members
8.8HLA-DQB1, HLA-DRB1, CD79A, IL6, IL2
30
Immune response Bacterial infections in normal airways
8.8IFNG, TNF, IL6, NOS2
31
Hide members
8.8IFNG, TNF, IL6, NOS2
328.8NOS2, IL6, TNF, IFNG
33
Hide members
8.7IFNG, TNF, IL6, IL2
34
Hide members
8.7IFNG, HLA-DQB1, HLA-DRB1, IL6, IL2
35
Hide members
8.6IL2, IL15, TNF, IFNG
36
Hide members
8.5IFNG, TNF, CD79A, IL4, IL2
378.5TNF, IL4, IL6, IL2, NOS2
388.4IFNG, TNF, IL6, IL2, NOS2
39
Development PDGF signaling via STATs and NF-kB
Hide members
8.4IFNG, TNF, IL6, IL2, NOS2
40
Hide members
8.4NOS2, IL2, IL6, TNF, IFNG
41
Hide members
8.4IFNG, HLA-DQB1, HLA-DRB1, CD79A, IL6, IL2
428.4IL2, IL6, IL4, IL15, IFNG
43
Hide members
8.3TNF, IL15, IL4, IL6, IL2
44
Hide members
8.3TNF, IL15, IL4, IL6, IL2
458.2IFNG, TNF, HLA-DQB1, HLA-DRB1, IL6, NOS2
468.0TNF, HLA-DQB1, HLA-DRB1, IL15, IL6, IL2
47
Hide members
8.0IFNG, TNF, HLA-DQB1, HLA-DRB1, CD79A, IL4
487.8IFNG, TNF, IL15, IL4, IL6, IL2
49
Hide members
7.7IFNG, TNF, HLA-DQB1, HLA-DRB1, IL15, IL4
50
Hide members
7.3IFNG, TNF, HLA-DQB1, HLA-DRB1, IL15, IL4

Compounds for genes affiliated with Microscopic Colitis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1pge24510.5IL2
2pentoxifylline45 1111.5IL4
3prednisolone45 29 1112.5CD79A
4ivig4510.2CD79A, IFNG
5melphalan45 1111.1TNF, CD79A
6gm-csf45 2911.0IFNG, TNF
72,5-oligoadenylate459.9IL2, TNF
8cyclosporin a45 29 6011.6IL15, IFNG, CD79A
9dexamethasone45 50 29 1112.6CD79A, IL6, IL15
10glatiramer acetate45 1110.4IL2, IFNG, IL4, HLA-DRB1
11c-d4t459.4IL15, IL4, IL2
12bucillamine459.4IL2, IL6, CD79A, IFNG
13con a459.4IL4, IL2, IFNG, CD79A
14gold sodium thiomalate459.3TNF, HLA-DRB1, IL2, IFNG
15interferon gamma459.3IL4, IFNG, TNF, IL2
16alpha-galactosylceramide459.2IL15, IL2, IFNG, IL4
17vesnarinone459.2NOS2, IL6, TNF, IFNG
18adalimumab45 50 1111.1TNF, CD79A, IL6, IFNG
19allergens459.1IFNG, HLA-DRB1, IL4, CD79A
20polymyxin b459.1IL4, IFNG, TNF, IL6
21parthenolide45 210.1IFNG, TNF, IL6, NOS2
22blys459.0CD79A, TNF, IL15
23methylcellulose459.0IFNG, IL15, IL4, IL6
24tacrolimus45 50 1110.9IL15, IFNG, CD79A, IL4, IL2
25herbimycin a45 609.9NOS2, IL2, TNF, IFNG, IL4
26mip 1alpha458.9TNF, IL6, IL4
27taurine chloramine458.8TNF, IL6, IL2, NOS2, IFNG
28triptolide458.8IL2, NOS2, IL6, TNF, IFNG
29etanercept45 50 1110.8IFNG, IL6, IL15, TNF
3015-deoxy-delta-12,14-prostaglandin j2458.8IFNG, TNF, IL6, NOS2, IL4
31pdtc458.8IFNG, NOS2, IL6, IL4, TNF
32chloroquine45 2 50 29 1112.8TNF, IL4, IL15, IL2, CD79A
33ccl345 299.7TNF, IL15, IL6, IFNG
34thalidomide45 50 60 1111.7IL2, IL6, TNF, IFNG
35rituximab45 50 1110.7IL15, IL6, CD79A, TNF, IL2
36poly(i-c)458.6TNF, IL4, IFNG, IL15, IL6
37infliximab45 50 1110.6IL6, IL15, TNF, IFNG, IL4
38calcitriol45 60 11 2411.6IL2, IL6, IL4, TNF, IFNG
39ionomycin458.5TNF, IL4, IL2, IFNG, IL15
40neopterin458.5CD79A, IFNG, IL2, IL6, IL4, TNF
41methotrexate45 50 1110.5IL15, IL6, TNF, HLA-DRB1, CD79A
42actinomycin d458.3IFNG, NOS2, IL2, IL6, TNF, IL4
43il-12458.3IL2, IL6, IL15, IFNG, TNF, IL4
44il 10458.3IFNG, IL2, IL6, IL4, IL15, TNF
45rantes458.2IL6, TNF, IL2, IL4, IL15, IFNG
46okt3458.0IL2, IFNG, TNF, CD79A, IL15, IL4
47histamine45 29 2410.0IL6, IL2, IL15, CD79A, TNF, IFNG
48polyinosinic-polycytidylic acid458.0IL6, IFNG, NOS2, IL2, TNF, IL15
49thymidine45 248.9IFNG, TNF, IL2, IL6, IL4, IL15
50vegf457.6IFNG, TNF, IL6, CD79A, IL2, IL4

GO Terms for genes affiliated with Microscopic Colitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.9HLA-DRB1, HLA-DQB1
2external side of plasma membraneGO:0098978.2IL6, IL4, CD79A, HLA-DRB1, TNF, IFNG
3extracellular spaceGO:0056157.5IFNG, TNF, IL15, IL4, IL6, IL2
4extracellular regionGO:0055767.0IFNG, MR1, TNF, IL15, IL6, IL2

Biological processes related to Microscopic Colitis according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.2HLA-DRB1, HLA-DQB1
2innate immune response in mucosaGO:00222710.2NOS2, IL4
3humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DQB1, HLA-DRB1
4positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
5positive regulation of MHC class II biosynthetic processGO:04534810.0IFNG, IL4
6neutrophil apoptotic processGO:00178110.0IFNG, IL6
7positive regulation of immunoglobulin secretionGO:0510249.9IL6, IL2
8positive regulation of vitamin D biosynthetic processGO:0605579.9IFNG, TNF
9positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IFNG, TNF
10positive regulation of tissue remodelingGO:0341059.9IL2, IL15
11interferon-gamma-mediated signaling pathwayGO:0603339.8IFNG, HLA-DQB1, HLA-DRB1
12epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8TNF, IL6
13negative regulation of lipid storageGO:0108889.8TNF, IL6
14positive regulation of isotype switching to IgG isotypesGO:0483049.8IL2, IL4, IFNG
15positive regulation of interleukin-17 productionGO:0327409.8IL15, IL2
16positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
17defense response to protozoanGO:0428329.7IFNG, IL4, IL6
18positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL4, IL2
20defense response to bacteriumGO:0427429.6LYZ, NOS2, IFNG
21negative regulation of growth of symbiont in hostGO:0441309.6TNF, IFNG
22positive regulation of chemokine biosynthetic processGO:0450809.6IL4, TNF, IFNG
23positive regulation of osteoclast differentiationGO:0456729.5IFNG, TNF
24positive regulation of nitric oxide biosynthetic processGO:0454299.5IL6, TNF, IFNG
25defense response to Gram-negative bacteriumGO:0508299.5NOS2, IL6, MR1
26regulation of insulin secretionGO:0507969.5NOS2, TNF, IFNG
27humoral immune responseGO:0069599.5IL6, TNF, IFNG
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, IL4, IL6
29cytokine-mediated signaling pathwayGO:0192219.4IFNG, HLA-DQB1, HLA-DRB1, IL6
30positive regulation of chemokine productionGO:0327229.2TNF, IL6
31positive regulation of T cell proliferationGO:0421029.1IFNG, IL15, IL4, IL6
32response to drugGO:0424939.1IFNG, TNF, IL4, IL6
33inflammatory responseGO:0069548.8TNF, IL15, IL6, NOS2, LYZ
34positive regulation of transcription from RNA polymerase II promoterGO:0459448.6IL2, IL6, IL4, TNF, IFNG
35immune responseGO:0069558.5MR1, HLA-DQB1, HLA-DRB1, IL15, IL4, IL2

Molecular functions related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.9HLA-DRB1, HLA-DQB1
2cytokine activityGO:0051257.5IL2, IL6, IL4, IL15, TNF, IFNG

Products for genes affiliated with Microscopic Colitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Microscopic Colitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet