MCID: MCR191
MIFTS: 54

Microscopic Colitis malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Microscopic Colitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Microscopic colitis refers to two medical conditions which cause diarrhea: collagenous colitis and... more...

MalaCards: Microscopic Colitis, also known as colitis, microscopic, is related to collagenous colitis and celiac disease. An important gene associated with Microscopic Colitis is LYZ (lysozyme), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and ICos-ICosL Pathway in T-Helper Cell. The compounds glatiramer acetate and con a have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Microscopic Colitis

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Sources:
50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
microscopic colitis:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

microscopic colitis 50
colitis, microscopic 63


External Ids:

MESH via Orphanet37 D046728
ICD10 via Orphanet27 K52.8
SNOMED-CT via Orphanet60 235753003
UMLS via Orphanet64 C0400821

Related Diseases for Microscopic Colitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1collagenous colitis30.9NOS2
2celiac disease30.5CD79A, IL15, HLA-DQB1
3inflammatory bowel disease30.5CD79A, IL6, IL2
4thyroiditis30.2HLA-DRB1, CD79A
5ulcerative colitis30.1TNF, LYZ
6diarrhea10.6
7irritable bowel syndrome10.4
8lymphocytic colitis10.3
9conjunctivitis10.1CD79A
10cryptosporidiosis10.1CD79A
11epidermolysis bullosa acquisita10.1CD79A
12pemphigus10.1CD79A
13sinusitis10.1CD79A
14capillary leak syndrome10.1IL2
15immunoglobulin alpha deficiency10.1CD79A, HLA-DQB1
16multiple sclerosis 110.1HLA-DQB1, HLA-DRB1
17infectious mononucleosis10.1CD79A, IL15
18pemphigus foliaceus10.1CD79A, HLA-DRB1
19myocarditis10.1NOS2
20dermatitis herpetiformis10.1CD79A, HLA-DQB1
21narcolepsy10.1HLA-DRB1
22selective iga deficiency disease10.1IL4, CD79A
23immunodeficiency with hyper igm type 110.1CD79A, IL4
24crohn's disease10.1TNF, LYZ
25periapical granuloma10.1NOS2, IL4
26leprosy10.1IL2, HLA-DRB1
27aspergillosis10.1CD79A, IFNG
28focal segmental glomerulosclerosis10.1NOS2, CD79A
29interstitial lung disease10.1TNF, CD79A
30leishmaniasis10.1IFNG, IL4
31psoriatic arthritis10.0TNF, HLA-DRB1
32aids dementia complex10.0TNF, NOS2
33visceral leishmaniasis10.0IL4, IFNG
34cutaneous leishmaniasis10.0IL4, IFNG
35polyclonal hypergammaglobulinemia10.0CD79A, IL6
36candidiasis10.0IFNG, CD79A
37mesangial proliferative glomerulonephritis10.0IL6, CD79A
38poems syndrome10.0IL6, CD79A
39agammaglobulinemia10.0IL4, IL2, CD79A
40immunodeficiency, common variable, 710.0CD79A, IL2, IL4
41systemic scleroderma10.0HLA-DQB1, HLA-DRB1, IL4
42common variable immune deficiency10.0IL4, IL2, CD79A
43gamma chain deficiency10.0IL4, IL2, IL15
44ankylosing spondylitis10.0TNF, CD79A
45type 1 diabetes mellitus10.0CD79A, IL15, HLA-DRB1, HLA-DQB1
46schistosomiasis10.0IFNG, IL4, CD79A
47hepatitis b10.0HLA-DQB1, HLA-DRB1, IFNG
48dermatitis10.0IFNG, IL4, CD79A
49tropical sprue10.0
50duodenitis10.0

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to microscopic colitis

Symptoms for Microscopic Colitis

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Drugs & Therapeutics for Microscopic Colitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Microscopic Colitis

Drug clinical trials:

Search ClinicalTrials for Microscopic Colitis

Search NIH Clinical Center for Microscopic Colitis

Search CenterWatch for Microscopic Colitis

Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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34MalaCards
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MalaCards organs/tissues related to Microscopic Colitis:

34
Colon, T cells, Bone, Thyroid

Animal Models for Microscopic Colitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Microscopic Colitis:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5HLA-DQB1, IFNG, IL4, IL6, NOS2, CD79A
2MP:00030128.4TNF, IFNG, IL4, IL2, CD79A
3MP:00020068.3TNF, IFNG, IL2, IL6, NOS2
4MP:00053918.2NOS2, IL6, IL4, IFNG, TNF
5MP:00053908.2NOS2, IL6, IL4, IFNG, TNF
6MP:00053698.1HLA-DQB1, TNF, IFNG, IL6, NOS2
7MP:00053707.8HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
8MP:00053887.8HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
9MP:00053817.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
10MP:00053797.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
11MP:00053897.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
12MP:00036317.7HLA-DQB1, TNF, IFNG, IL4, IL6, NOS2
13MP:00053857.5HLA-DQB1, TNF, IFNG, IL2, IL15, IL6
14MP:00053867.5HLA-DQB1, TNF, IFNG, IL2, IL6, NOS2
15MP:00053847.4HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
16MP:00053767.4HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
17MP:00053787.1HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
18MP:00107687.1HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
19MP:00053976.7CD79A, MR1, HLA-DQB1, TNF, IFNG, IL4
20MP:00053876.7MR1, HLA-DQB1, TNF, IFNG, IL4, IL2

Publications for Microscopic Colitis

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Sources:
53PubMed
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Articles related to Microscopic Colitis:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Microscopic Colitis - Clinical and Pathologic Perspectives. (24407107)
2014
2
The Epidemiology of Microscopic Colitis in Olmsted County From 2002 to 2010: A Population-Based Study. (24120840)
2013
3
Microscopic colitis: a therapeutic challenge. (23801853)
2013
4
Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. (23600961)
2013
5
Microscopic colitis patients have increased proportions of Ki67(+) proliferating and CD45RO(+) active/memory CD8(+) and CD4(+)8(+) mucosal T cells. (22995775)
2013
6
Epidemiological risk factors in microscopic colitis: a prospective case-control study. (23344243)
2013
7
Is microscopic colitis a drug-induced disease? (23060216)
2012
8
Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group. (22704658)
2012
9
Decreased colorectal cancer and adenoma risk in patients with microscopic colitis. (21847567)
2012
10
Juvenile spondyloarthritis with microscopic colitis. (22885441)
2012
11
Clinical course of microscopic colitis in a single-center cohort study. (21575884)
2011
12
Microscopic colitis: clinical findings, topography and persistence of histopathological subgroups. (21967618)
2011
13
Efficacy of anti-TNF therapies in refractory severe microscopic colitis. (22115383)
2011
14
Cytokine gene polymorphism in microscopic colitis association with the IL-6-174 GG genotype. (21527852)
2011
15
Microscopic colitis. (21303675)
2011
16
Low bone mass in microscopic colitis. (21595910)
2011
17
Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study. (21039674)
2010
18
Microscopic colitis: a concise review. (20931164)
2010
19
Patients with drug-induced microscopic colitis should not be included in controlled trials assessing the efficacy of anti-inflammatory drugs in microscopic colitis. (19717133)
2009
20
Microscopic colitis: a review for the surgical endoscopist. (19865548)
2009
21
Microscopic colitis and endoscopy. (19841492)
2009
22
Microscopic colitis: a common and an easily overlooked cause of chronic diarrhoea. (18395161)
2008
23
Diagnosis and management of microscopic colitis. (19109861)
2008
24
Microscopic colitis with giant cells: a clinico-pathological review of 11 cases and comparison with microscopic colitis without giant cells. (18985521)
2008
25
The risk of microscopic colitis in solid-organ transplantation patients: a population-based study. (18192911)
2008
26
Clozapine-induced microscopic colitis: a case report and review of the literature. (18004122)
2007
27
The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. (17135309)
2007
28
How much symptom overlap is there between microscopic colitis and IBS? (17438567)
2007
29
Drug consumption and the risk of microscopic colitis. (17100977)
2007
30
Spectrum of microscopic colitis in a tertiary care centre in India. (18384001)
2007
31
Autoantibody profiles in microscopic colitis. (16724988)
2006
32
A higher diagnostic profile is possible for microscopic colitis. (16886923)
2006
33
Microscopic colitis in routine colonoscopies. (16534662)
2006
34
Is there an association of microscopic colitis and irritable bowel syndrome--a subgroup analysis of placebo-controlled trials. (16425407)
2005
35
Microscopic colitis: prevalence and distribution throughout the colon in patients with chronic diarrhoea. (15869041)
2005
36
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. (15641395)
2004
37
Microscopic colitis with giant cells: a rare new histopathologic subtype? (14765272)
2004
38
Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998. (14960513)
2004
39
Microscopic colitis. (15703617)
2004
40
Microscopic colitis. (12744549)
2003
41
Lansoprazole-associated microscopic colitis: a case series. (12425567)
2002
42
Microscopic colitis: a clinical and pathological review. (12465719)
2002
43
Postcholecystectomy microscopic colitis: is bile acid malabsorption a triggering factor? (11374729)
2001
44
Familial occurrence of microscopic colitis: a report on five families. (11521987)
2001
45
Pathophysiology and treatment of microscopic-colitis syndrome. (10770295)
2000
46
Microscopic colitis--no longer an appropriate term? (9576441)
1998
47
Microscopic colitis syndrome. (7615277)
1995
48
Association of lymphocytic (microscopic) colitis with tropical sprue. (8155860)
1994
49
Response to treatment of microscopic colitis. (7919463)
1994
50
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990

Variations for Microscopic Colitis

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Expression for genes affiliated with Microscopic Colitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for genes affiliated with Microscopic Colitis

About this section
Sources:
51PathCards, 55R&D Systems, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Pathways related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6, IL4
2
Show member pathways
9.4IL2, HLA-DRB1, HLA-DQB1
3
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.4HLA-DQB1, HLA-DRB1, IL2
49.3IL2, IFNG, HLA-DRB1
59.3IFNG, IL4, IL2
69.3IFNG, IL4, IL2
7
Show member pathways
9.2IFNG, IL4, IL6
8
Show member pathways
9.1IFNG, IL6, NOS2
99.1IFNG, IL6, NOS2
109.1NOS2, IL6, IFNG
11
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0IL2, IFNG, TNF
129.0TNF, IL6, NOS2
138.9IL6, IFNG, TNF
148.9IL6, IFNG, TNF
15
Show member pathways
thioredoxin pathway39
8.9IL6, IFNG, TNF
168.9TNF, IFNG, IL6
178.8IL6, IL15, TNF
188.7IL6, IL2, IL4, IFNG
198.7IL6, IL4, TNF, HLA-DRB1
20
Show member pathways
Immune response CD16 signaling in NK cells61
8.6IL2, IL4, IFNG, TNF
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.6TNF, IFNG, IL4, IL2
22
Show member pathways
8.6CD79A, IL6, IL2, HLA-DRB1, HLA-DQB1
23
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.6HLA-DRB1, IFNG, IL4, IL2, NOS2
24
Show member pathways
8.5HLA-DQB1, HLA-DRB1, TNF, LYZ, IFNG
25
Show member pathways
Immune response MIF in innate immunity response61
8.5TNF, IFNG, IL6, NOS2
268.5NOS2, IL6, IFNG, TNF
27
Show member pathways
8.5HLA-DQB1, HLA-DRB1, IFNG, IL2, IL6
28
Show member pathways
IL27-mediated signaling events39
8.5TNF, IFNG, IL2, IL6
29
Show member pathways
8.5IL15, IL2, IFNG, TNF
30
Show member pathways
Type III interferon signaling39
8.2IFNG, IL4, IL2, IL15, IL6
31
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.2TNF, IFNG, IL4, IL6, NOS2
32
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.1TNF, IFNG, IL2, IL6, NOS2
33
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.1TNF, IFNG, IL2, IL6, NOS2
348.1TNF, IFNG, IL2, IL6, NOS2
35
Show member pathways
8.1TNF, IL4, IL2, IL15, IL6
36
Show member pathways
8.1TNF, IL4, IL2, IL15, IL6
37
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.1TNF, IL4, IL2, IL15, IL6
387.9HLA-DQB1, HLA-DRB1, TNF, IFNG, IL6, NOS2
39
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
7.8TNF, IFNG, IL4, IL2, IL6, CD79A
407.8HLA-DQB1, HLA-DRB1, TNF, IL2, IL15, IL6
417.7TNF, IFNG, IL4, IL2, IL6, NOS2
42
Show member pathways
7.7HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
437.7HLA-DQB1, HLA-DRB1, TNF, IFNG, IL15, IL6
44
Show member pathways
7.6TNF, IFNG, IL4, IL2, IL15, IL6
457.6TNF, IFNG, IL4, IL2, IL15, IL6
46
Show member pathways
7.6TNF, IFNG, IL4, IL2, IL15, IL6
477.3IL6, HLA-DRB1, TNF, IFNG, IL4, IL2
48
Show member pathways
7.1HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
49
Show member pathways
7.0HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
50
Show member pathways
7.0HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2

Compounds for genes affiliated with Microscopic Colitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Microscopic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate46 1210.3HLA-DRB1, IFNG, IL4, IL2
2con a469.3IL2, IFNG, CD79A, IL4
3bucillamine469.2CD79A, IL2, IL6, IFNG
4c-d4t469.2IL4, IL2, IL15
5alpha-galactosylceramide469.1IL4, IL15, IL2, IFNG
6rantes469.1IL2, IL15, IL4, IFNG
7interferon gamma469.1IFNG, IL4, IL2, TNF
8gold sodium thiomalate469.0IFNG, HLA-DRB1, TNF, IL2
9vesnarinone468.9TNF, IFNG, IL6, NOS2
10adalimumab46 52 1210.9CD79A, TNF, IFNG, IL6
11mycophenolate mofetil46 52 1210.8CD79A, TNF, IFNG, IL2
12polymyxin b468.8IL4, IFNG, TNF, IL6
13methylcellulose468.8IL15, IFNG, IL4, IL6
14parthenolide46 39.8IFNG, NOS2, IL6, TNF
152,5-oligoadenylate468.7IFNG, TNF, IL6, IL2
16ivig468.6TNF, IFNG, IL4, IL6, CD79A
17melphalan46 52 1210.6CD79A, IL6, IL4, TNF, IFNG
18chloroquine46 3 52 30 1212.6IL4, TNF, IL2, IL15, CD79A
19taurine chloramine468.5IL2, TNF, IFNG, IL6, NOS2
20etanercept46 52 1210.5IL15, IL6, IFNG, TNF
21triptolide468.5IL6, NOS2, TNF, IL2, IFNG
22pentoxifylline46 129.5IL6, IL2, IL4, IFNG, TNF
2315-deoxy-delta-12,14-prostaglandin j2468.5IL6, IFNG, TNF, IL4, NOS2
24pdtc468.5TNF, NOS2, IFNG, IL4, IL6
25prednisolone46 30 1210.5IL2, IFNG, TNF, IL6, CD79A
26rituximab46 52 1210.5IL2, IL6, TNF, IL15, CD79A
27poly(i-c)468.4IFNG, TNF, IL6, IL4, IL15
28infliximab46 52 1210.4IL6, IL15, IL4, IFNG, TNF
29ionomycin468.3IL2, TNF, IL15, IL4, IFNG
30neopterin468.3IL2, TNF, IL4, CD79A, IFNG, IL6
31ccl346 309.3TNF, IL15, IFNG, IL6
32tacrolimus46 52 1210.2IL2, IL15, CD79A, TNF, IFNG, IL4
33calcitriol46 62 25 1211.2TNF, IL4, IL6, IFNG, IL2
34herbimycin a46 629.2IL2, TNF, IFNG, IL4, IL6, NOS2
35il-12468.1IL15, TNF, IL6, IL2, IL4, IFNG
36gm-csf46 309.0IL6, IL15, IL2, IL4, TNF, IFNG
37il 10468.0IL6, IL2, IL4, IFNG, TNF, IL15
38hydrocortisone46 3 62 1211.0IFNG, TNF, IL4, IL2, IL6, IL15
39actinomycin d468.0NOS2, IL6, TNF, IFNG, IL4, IL2
40methotrexate52 46 129.9HLA-DRB1, TNF, IL15, CD79A, IL6
41indomethacin46 30 62 1210.9CD79A, IL6, NOS2, IL2, IL4, IFNG
42okt3467.8CD79A, IL2, IL4, IFNG, TNF, IL15
43histamine46 30 259.7IFNG, IL4, CD79A, IL15, IL2, TNF
44cyclosporin a46 30 629.7CD79A, IL6, IL15, IL2, IL4, IFNG
45polyinosinic-polycytidylic acid467.7IL15, NOS2, IL6, TNF, IFNG, IL4
46thymidine46 258.6IL15, TNF, IL2, IFNG, IL4, IL6
47cycloheximide467.5IL15, IL2, IL4, IFNG, NOS2, TNF
48pge2467.4IL15, IL4, CD79A, TNF, IFNG, NOS2
49dexamethasone46 52 30 1210.3IL6, IL15, IL2, IL4, CD79A, IFNG
50vegf467.3CD79A, NOS2, TNF, IFNG, IL4, IL2

GO Terms for genes affiliated with Microscopic Colitis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.9HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306699.9HLA-DQB1, HLA-DRB1
4trans-Golgi network membraneGO:0325889.9HLA-DRB1, HLA-DQB1
5transport vesicle membraneGO:0306589.8HLA-DRB1, HLA-DQB1
6ER to Golgi transport vesicle membraneGO:0125079.6HLA-DRB1, HLA-DQB1
7external side of plasma membraneGO:0098978.1CD79A, IL6, IL4, IFNG, TNF, HLA-DRB1
8extracellular regionGO:0055767.6MR1, TNF, LYZ, IFNG, IL2, IL15
9extracellular spaceGO:0056157.5TNF, LYZ, IFNG, IL4, IL2, IL15

Biological processes related to Microscopic Colitis according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.2HLA-DQB1, HLA-DRB1
2humoral immune response mediated by circulating immunoglobulinGO:00245510.2HLA-DQB1, HLA-DRB1
3innate immune response in mucosaGO:00222710.1IL4, NOS2
4positive regulation of killing of cells of other organismGO:05171210.1NOS2, IFNG
5positive regulation of MHC class II biosynthetic processGO:04534810.0IFNG, IL4
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0IL2, IL4
7positive regulation of activated T cell proliferationGO:04210410.0IL4, IL2
8positive regulation of tissue remodelingGO:0341059.9IL2, IL15
9neutrophil apoptotic processGO:0017819.9IL6, IFNG
10positive regulation of immunoglobulin secretionGO:0510249.9IL2, IL6
11antigen processing and presentationGO:0198829.9MR1, IFNG
12positive regulation of interleukin-17 productionGO:0327409.9IL15, IL2
13positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
14positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IFNG, TNF
15interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DQB1, HLA-DRB1, IFNG
16positive regulation of B cell proliferationGO:0308909.8IL2, IL4
17defense response to Gram-negative bacteriumGO:0508299.7NOS2, IL6, MR1
18extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL2, IL4
19defense response to bacteriumGO:0427429.7LYZ, IFNG, NOS2
20positive regulation of isotype switching to IgG isotypesGO:0483049.7IFNG, IL4, IL2
21positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
22epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7TNF, IL6
23negative regulation of growth of symbiont in hostGO:0441309.7TNF, IFNG
24negative regulation of lipid storageGO:0108889.7TNF, IL6
25negative regulation of smooth muscle cell proliferationGO:0486629.7IL15, IFNG
26positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNF
27positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6IL6, IL15
28protein import into nucleus, translocationGO:0000609.6IFNG, TNF
29positive regulation of chemokine productionGO:0327229.6TNF, IL6
30defense response to protozoanGO:0428329.6IL6, IL4, IFNG
31positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IFNG, IL4
32defense response to Gram-positive bacteriumGO:0508309.4IL6, TNF
33extrinsic apoptotic signaling pathwayGO:0971919.4TNF, IFNG
34regulation of insulin secretionGO:0507969.4TNF, IFNG, NOS2
35positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL6, IL4, TNF
36positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, IFNG, TNF
37cytokine-mediated signaling pathwayGO:0192219.3HLA-DQB1, HLA-DRB1, IFNG, IL6
38humoral immune responseGO:0069599.3IL6, IFNG, TNF
39negative regulation of fat cell differentiationGO:0455999.2TNF, IL6
40positive regulation of interferon-gamma productionGO:0327299.1IL2, TNF
41positive regulation of T cell proliferationGO:0421029.1IL6, IL15, IL4, IFNG
42response to drugGO:0424938.9TNF, IFNG, IL4, IL6
43immune responseGO:0069558.7IL15, IL2, IL4, HLA-DRB1, HLA-DQB1, MR1
44inflammatory responseGO:0069548.6TNF, LYZ, IL15, IL6, NOS2
45positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TNF, IFNG, IL4, IL2, IL6

Molecular functions related to Microscopic Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.9HLA-DRB1, MR1
2MHC class II receptor activityGO:0323959.8HLA-DQB1, HLA-DRB1
3growth factor activityGO:0080838.9IL6, IL2, IL4
4cytokine activityGO:0051257.6IL6, IL15, IL2, IL4, IFNG, TNF

Products for genes affiliated with Microscopic Colitis

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  • Antibodies
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Sources for Microscopic Colitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet