MCID: MCR191
MIFTS: 48

Microscopic Colitis malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Microscopic Colitis

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Wikipedia:63 Microscopic colitis refers to two medical conditions which cause diarrhea: collagenous colitis and... more...

MalaCards based summary: Microscopic Colitis, also known as colitis, microscopic, is related to collagenous colitis and colitis. An important gene associated with Microscopic Colitis is LYZ (lysozyme), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and ICos-ICosL Pathway in T-Helper Cell. The compounds glatiramer acetate and con a have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology:9 A colitis that can only be diagnosed by the examination of colon tissue under a microscope.

Aliases & Classifications for Microscopic Colitis

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Sources:
9Disease Ontology, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Microscopic Colitis, Aliases & Descriptions:

Name: Microscopic Colitis 9 47
 
Colitis, Microscopic 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
microscopic colitis:
Prevalence: 1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:0060182
NCIt38 C38504
MeSH33 D046728
ICD9CM27 558.9
Orphanet47 58220
MESH via Orphanet34 D046728
ICD10 via Orphanet26 K52.8
UMLS via Orphanet61 C0400821

Related Diseases for Microscopic Colitis

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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1collagenous colitis31.5NOS2
2colitis31.0NOS2, IL6, IL4, IFNG, TNF
3ulcerative colitis30.9TNF, LYZ
4celiac disease30.8CD79A, IL15, HLA-DQB1
5thyroiditis30.6HLA-DRB1, CD79A
6inflammatory bowel disease30.5CD79A, IL6, IL2
7diarrhea10.7
8conjunctivitis10.5CD79A
9cryptosporidiosis10.5CD79A
10epidermolysis bullosa acquisita10.5CD79A
11pemphigus10.5CD79A
12irritable bowel syndrome10.5
13sinusitis10.4CD79A
14capillary leak syndrome10.4IL2
15immunoglobulin alpha deficiency10.4CD79A, HLA-DQB1
16multiple sclerosis, disease progression, modifier of10.4HLA-DQB1, HLA-DRB1
17pfeiffer syndrome10.4CD79A, IL15
18pemphigus foliaceus10.3CD79A, HLA-DRB1
19myocarditis10.3NOS2
20dermatitis herpetiformis10.3CD79A, HLA-DQB1
21selective iga deficiency disease10.3IL4, CD79A
22immunodeficiency, x-linked, with hyper-igm10.3CD79A, IL4
23narcolepsy10.3HLA-DRB1
24crohn's disease10.3TNF, LYZ
25periapical granuloma10.3NOS2, IL4
26leprosy10.3IL2, HLA-DRB1
27aspergillosis10.3CD79A, IFNG
28lymphocytic colitis10.3
29focal segmental glomerulosclerosis10.3NOS2, CD79A
30interstitial lung disease10.2TNF, CD79A
31leishmaniasis10.2IFNG, IL4
32psoriatic arthritis10.2TNF, HLA-DRB1
33aids dementia complex10.2TNF, NOS2
34visceral leishmaniasis10.2IL4, IFNG
35cutaneous leishmaniasis10.2IL4, IFNG
36adenoma10.2
37polyclonal hypergammaglobulinemia10.2CD79A, IL6
38candidiasis10.2IFNG, CD79A
39mesangial proliferative glomerulonephritis10.2IL6, CD79A
40poems syndrome10.1IL6, CD79A
41agammaglobulinemia10.1IL4, IL2, CD79A
42systemic scleroderma10.1HLA-DQB1, HLA-DRB1, IL4
43common variable immunodeficiency10.1IL4, IL2, CD79A
44severe combined immunodeficiency, x-linked10.1IL4, IL2, IL15
45spondyloarthropathy 110.1TNF, CD79A
46diabetes mellitus, insulin-dependent10.1CD79A, IL15, HLA-DRB1, HLA-DQB1
47schistosomiasis10.1IFNG, IL4, CD79A
48hepatitis b10.1HLA-DQB1, HLA-DRB1, IFNG
49dermatitis10.1IFNG, IL4, CD79A
50meningitis10.1LYZ, IL6, CD79A

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to microscopic colitis

Symptoms for Microscopic Colitis

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Drugs & Therapeutics for Microscopic Colitis

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Drug clinical trials:

Search ClinicalTrials for Microscopic Colitis

Search NIH Clinical Center for Microscopic Colitis

Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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MalaCards organs/tissues related to Microscopic Colitis:

31
Colon, T cells, Bone, Small intestine, Thyroid

Animal Models for Microscopic Colitis or affiliated genes

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MGI Mouse Phenotypes related to Microscopic Colitis:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5HLA-DQB1, IFNG, IL4, IL6, NOS2, CD79A
2MP:00030128.4TNF, IFNG, IL4, IL2, CD79A
3MP:00020068.3TNF, IFNG, IL2, IL6, NOS2
4MP:00053918.2NOS2, IL6, IL4, IFNG, TNF
5MP:00053908.2NOS2, IL6, IL4, IFNG, TNF
6MP:00053698.1HLA-DQB1, TNF, IFNG, IL6, NOS2
7MP:00053707.8HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
8MP:00053887.8HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
9MP:00053817.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
10MP:00053797.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
11MP:00053897.7HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
12MP:00036317.7HLA-DQB1, TNF, IFNG, IL4, IL6, NOS2
13MP:00053857.5HLA-DQB1, TNF, IFNG, IL2, IL15, IL6
14MP:00053867.5HLA-DQB1, TNF, IFNG, IL2, IL6, NOS2
15MP:00053847.4HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
16MP:00053767.4HLA-DQB1, TNF, IFNG, IL4, IL2, IL6
17MP:00053787.1HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
18MP:00107687.1HLA-DQB1, TNF, IFNG, IL4, IL2, IL15
19MP:00053976.7CD79A, MR1, HLA-DQB1, TNF, IFNG, IL4
20MP:00053876.7MR1, HLA-DQB1, TNF, IFNG, IL4, IL2

Publications for Microscopic Colitis

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Articles related to Microscopic Colitis:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
P080. Persistence and sensitivity of colonic biopsies for microscopic colitis in a regional cohort. (25717537)
2015
2
OP010. Medication-induced microscopic colitis: do recency and duration of use matter? (25718276)
2015
3
Is microscopic colitis really microscopic? (25720998)
2015
4
Drug exposure and risk of microscopic colitis: a nationwide Danish case-control study with 5751 cases. (25153503)
2014
5
Microscopic colitis: Common cause of unexplained nonbloody diarrhea. (24891975)
2014
6
Microscopic Colitis - Clinical and Pathologic Perspectives. (24407107)
2014
7
Smoking- and alcohol habits in relation to the clinical picture of women with microscopic colitis compared to controls. (24456904)
2014
8
Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. (25665881)
2014
9
Microscopic colitis occurring in association with hyperplastic polyps and tubulovillous adenomas: observations in 10 cases. (25143518)
2014
10
Diagnosis and management of microscopic colitis: current perspectives. (25170275)
2014
11
Histology of Microscopic Colitis - Review with Practical Approach for Pathologists. (25381724)
2014
12
Microscopic Colitis: A Review. (25039699)
2014
13
Letter: Persisting clinical symptoms in microscopic colitis in remission--authors' reply. (24903433)
2014
14
Evolution of Microscopic Colitis to Giant Cell Colitis Without Significant Intraepithelial Lymphocytosis or Thickened Collagen Plate. (25006169)
2014
15
The Epidemiology of Microscopic Colitis in Olmsted County From 2002 to 2010: A Population-Based Study. (24120840)
2013
16
Microscopic colitis: a therapeutic challenge. (23801853)
2013
17
Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. (23600961)
2013
18
Microscopic colitis patients have increased proportions of Ki67(+) proliferating and CD45RO(+) active/memory CD8(+) and CD4(+)8(+) mucosal T cells. (22995775)
2013
19
Is microscopic colitis a drug-induced disease? (23060216)
2012
20
Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group. (22704658)
2012
21
Decreased colorectal cancer and adenoma risk in patients with microscopic colitis. (21847567)
2012
22
Juvenile spondyloarthritis with microscopic colitis. (22885441)
2012
23
Clinical course of microscopic colitis in a single-center cohort study. (21575884)
2011
24
Microscopic colitis: clinical findings, topography and persistence of histopathological subgroups. (21967618)
2011
25
Efficacy of anti-TNF therapies in refractory severe microscopic colitis. (22115383)
2011
26
Cytokine gene polymorphism in microscopic colitis association with the IL-6-174 GG genotype. (21527852)
2011
27
Microscopic colitis. (21303675)
2011
28
Low bone mass in microscopic colitis. (21595910)
2011
29
Patients with drug-induced microscopic colitis should not be included in controlled trials assessing the efficacy of anti-inflammatory drugs in microscopic colitis. (19717133)
2009
30
Microscopic colitis: a review for the surgical endoscopist. (19865548)
2009
31
Microscopic colitis and endoscopy. (19841492)
2009
32
Microscopic colitis: a common and an easily overlooked cause of chronic diarrhoea. (18395161)
2008
33
Diagnosis and management of microscopic colitis. (19109861)
2008
34
Microscopic colitis with giant cells: a clinico-pathological review of 11 cases and comparison with microscopic colitis without giant cells. (18985521)
2008
35
Clozapine-induced microscopic colitis: a case report and review of the literature. (18004122)
2007
36
The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. (17135309)
2007
37
How much symptom overlap is there between microscopic colitis and IBS? (17438567)
2007
38
Drug consumption and the risk of microscopic colitis. (17100977)
2007
39
Autoantibody profiles in microscopic colitis. (16724988)
2006
40
A higher diagnostic profile is possible for microscopic colitis. (16886923)
2006
41
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. (15641395)
2004
42
Microscopic colitis with giant cells: a rare new histopathologic subtype? (14765272)
2004
43
Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998. (14960513)
2004
44
Microscopic colitis. (12744549)
2003
45
Lansoprazole-associated microscopic colitis: a case series. (12425567)
2002
46
Postcholecystectomy microscopic colitis: is bile acid malabsorption a triggering factor? (11374729)
2001
47
Microscopic colitis syndrome. (7615277)
1995
48
Association of lymphocytic (microscopic) colitis with tropical sprue. (8155860)
1994
49
Response to treatment of microscopic colitis. (7919463)
1994
50
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990

Variations for Microscopic Colitis

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Expression for genes affiliated with Microscopic Colitis

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Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for genes affiliated with Microscopic Colitis

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Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6, IL4
2
Show member pathways
9.4IL2, HLA-DRB1, HLA-DQB1
3
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.4HLA-DQB1, HLA-DRB1, IL2
49.3IL2, IFNG, HLA-DRB1
59.3IFNG, IL4, IL2
69.3IFNG, IL4, IL2
7
Show member pathways
9.2IFNG, IL4, IL6
8
Show member pathways
9.1IFNG, IL6, NOS2
99.1IFNG, IL6, NOS2
109.1NOS2, IL6, IFNG
11
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0IL2, IFNG, TNF
129.0TNF, IL6, NOS2
138.9IL6, IFNG, TNF
148.9IL6, IFNG, TNF
15
Show member pathways
thioredoxin pathway36
8.9IL6, IFNG, TNF
168.9TNF, IFNG, IL6
178.8IL6, IL15, TNF
188.7IL6, IL2, IL4, IFNG
198.7IL6, IL4, TNF, HLA-DRB1
20
Show member pathways
Immune response CD16 signaling in NK cells58
8.6IL2, IL4, IFNG, TNF
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.6TNF, IFNG, IL4, IL2
22
Show member pathways
8.6CD79A, IL6, IL2, HLA-DRB1, HLA-DQB1
23
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.6HLA-DRB1, IFNG, IL4, IL2, NOS2
24
Show member pathways
8.5HLA-DQB1, HLA-DRB1, TNF, LYZ, IFNG
25
Show member pathways
Immune response MIF in innate immunity response58
8.5TNF, IFNG, IL6, NOS2
268.5NOS2, IL6, IFNG, TNF
27
Show member pathways
8.5HLA-DQB1, HLA-DRB1, IFNG, IL2, IL6
28
Show member pathways
IL27-mediated signaling events36
8.5TNF, IFNG, IL2, IL6
29
Show member pathways
8.5IL15, IL2, IFNG, TNF
30
Show member pathways
Type III interferon signaling36
8.2IFNG, IL4, IL2, IL15, IL6
31
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.2TNF, IFNG, IL4, IL6, NOS2
32
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.1TNF, IFNG, IL2, IL6, NOS2
33
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.1TNF, IFNG, IL2, IL6, NOS2
348.1TNF, IFNG, IL2, IL6, NOS2
35
Show member pathways
8.1TNF, IL4, IL2, IL15, IL6
36
Show member pathways
8.1TNF, IL4, IL2, IL15, IL6
37
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.1TNF, IL4, IL2, IL15, IL6
387.9HLA-DQB1, HLA-DRB1, TNF, IFNG, IL6, NOS2
39
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.8TNF, IFNG, IL4, IL2, IL6, CD79A
407.8HLA-DQB1, HLA-DRB1, TNF, IL2, IL15, IL6
417.7TNF, IFNG, IL4, IL2, IL6, NOS2
42
Show member pathways
7.7HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
437.7HLA-DQB1, HLA-DRB1, TNF, IFNG, IL15, IL6
44
Show member pathways
7.6TNF, IFNG, IL4, IL2, IL15, IL6
457.6TNF, IFNG, IL4, IL2, IL15, IL6
46
Show member pathways
7.6TNF, IFNG, IL4, IL2, IL15, IL6
477.3IL6, HLA-DRB1, TNF, IFNG, IL4, IL2
48
Show member pathways
7.1HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
49
Show member pathways
7.0HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2
50
Show member pathways
7.0HLA-DQB1, HLA-DRB1, TNF, IFNG, IL4, IL2

Compounds for genes affiliated with Microscopic Colitis

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Compounds related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate43 1210.3HLA-DRB1, IFNG, IL4, IL2
2con a439.3IL2, IFNG, CD79A, IL4
3bucillamine439.2CD79A, IL2, IL6, IFNG
4c-d4t439.2IL4, IL2, IL15
5alpha-galactosylceramide439.1IL4, IL15, IL2, IFNG
6rantes439.1IL2, IL15, IL4, IFNG
7interferon gamma439.1IFNG, IL4, IL2, TNF
8gold sodium thiomalate439.0IFNG, HLA-DRB1, TNF, IL2
9vesnarinone438.9TNF, IFNG, IL6, NOS2
10adalimumab43 49 1210.9CD79A, TNF, IFNG, IL6
11mycophenolate mofetil43 49 1210.8CD79A, TNF, IFNG, IL2
12polymyxin b438.8IL4, IFNG, TNF, IL6
13methylcellulose438.8IL15, IFNG, IL4, IL6
14parthenolide43 29.8IFNG, NOS2, IL6, TNF
152,5-oligoadenylate438.7IFNG, TNF, IL6, IL2
16ivig438.6TNF, IFNG, IL4, IL6, CD79A
17melphalan43 49 1210.6CD79A, IL6, IL4, TNF, IFNG
18chloroquine43 2 49 28 1212.6IL4, TNF, IL2, IL15, CD79A
19taurine chloramine438.5IL2, TNF, IFNG, IL6, NOS2
20etanercept43 49 1210.5IL15, IL6, IFNG, TNF
21triptolide438.5IL6, NOS2, TNF, IL2, IFNG
22pentoxifylline43 129.5IL6, IL2, IL4, IFNG, TNF
2315-deoxy-delta-12,14-prostaglandin j2438.5IL6, IFNG, TNF, IL4, NOS2
24pdtc438.5TNF, NOS2, IFNG, IL4, IL6
25prednisolone43 28 1210.5IL2, IFNG, TNF, IL6, CD79A
26rituximab43 49 1210.5IL2, IL6, TNF, IL15, CD79A
27poly(i-c)438.4IFNG, TNF, IL6, IL4, IL15
28infliximab43 49 1210.4IL6, IL15, IL4, IFNG, TNF
29ionomycin438.3IL2, TNF, IL15, IL4, IFNG
30neopterin438.3IL2, TNF, IL4, CD79A, IFNG, IL6
31ccl343 289.3TNF, IL15, IFNG, IL6
32tacrolimus43 49 1210.2IL2, IL15, CD79A, TNF, IFNG, IL4
33calcitriol43 59 24 1211.2TNF, IL4, IL6, IFNG, IL2
34herbimycin a43 599.2IL2, TNF, IFNG, IL4, IL6, NOS2
35il-12438.1IL15, TNF, IL6, IL2, IL4, IFNG
36gm-csf43 289.0IL6, IL15, IL2, IL4, TNF, IFNG
37il 10438.0IL6, IL2, IL4, IFNG, TNF, IL15
38hydrocortisone43 2 59 1211.0IFNG, TNF, IL4, IL2, IL6, IL15
39actinomycin d438.0NOS2, IL6, TNF, IFNG, IL4, IL2
40methotrexate49 43 129.9HLA-DRB1, TNF, IL15, CD79A, IL6
41indomethacin43 28 59 1210.9CD79A, IL6, NOS2, IL2, IL4, IFNG
42okt3437.8CD79A, IL2, IL4, IFNG, TNF, IL15
43histamine43 28 249.7IFNG, IL4, CD79A, IL15, IL2, TNF
44cyclosporin a43 28 599.7CD79A, IL6, IL15, IL2, IL4, IFNG
45polyinosinic-polycytidylic acid437.7IL15, NOS2, IL6, TNF, IFNG, IL4
46thymidine43 248.6IL15, TNF, IL2, IFNG, IL4, IL6
47cycloheximide437.5IL15, IL2, IL4, IFNG, NOS2, TNF
48pge2437.4IL15, IL4, CD79A, TNF, IFNG, NOS2
49dexamethasone43 49 28 1210.3IL6, IL15, IL2, IL4, CD79A, IFNG
50vegf437.3CD79A, NOS2, TNF, IFNG, IL4, IL2

GO Terms for genes affiliated with Microscopic Colitis

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Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.0HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.9HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:00306699.9HLA-DQB1, HLA-DRB1
4trans-Golgi network membraneGO:00325889.9HLA-DRB1, HLA-DQB1
5transport vesicle membraneGO:00306589.8HLA-DRB1, HLA-DQB1
6ER to Golgi transport vesicle membraneGO:00125079.6HLA-DRB1, HLA-DQB1
7external side of plasma membraneGO:00098978.1CD79A, IL6, IL4, IFNG, TNF, HLA-DRB1
8extracellular regionGO:00055767.6MR1, TNF, LYZ, IFNG, IL2, IL15
9extracellular spaceGO:00056157.5TNF, LYZ, IFNG, IL4, IL2, IL15

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.2HLA-DQB1, HLA-DRB1
2humoral immune response mediated by circulating immunoglobulinGO:000245510.2HLA-DQB1, HLA-DRB1
3innate immune response in mucosaGO:000222710.1IL4, NOS2
4positive regulation of killing of cells of other organismGO:005171210.1NOS2, IFNG
5positive regulation of MHC class II biosynthetic processGO:004534810.0IFNG, IL4
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0IL2, IL4
7positive regulation of activated T cell proliferationGO:004210410.0IL4, IL2
8positive regulation of tissue remodelingGO:00341059.9IL2, IL15
9neutrophil apoptotic processGO:00017819.9IL6, IFNG
10positive regulation of immunoglobulin secretionGO:00510249.9IL2, IL6
11antigen processing and presentationGO:00198829.9MR1, IFNG
12positive regulation of interleukin-17 productionGO:00327409.9IL15, IL2
13positive regulation of vitamin D biosynthetic processGO:00605579.8TNF, IFNG
14positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8IFNG, TNF
15interferon-gamma-mediated signaling pathwayGO:00603339.8HLA-DQB1, HLA-DRB1, IFNG
16positive regulation of B cell proliferationGO:00308909.8IL2, IL4
17defense response to Gram-negative bacteriumGO:00508299.7NOS2, IL6, MR1
18extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL2, IL4
19defense response to bacteriumGO:00427429.7LYZ, IFNG, NOS2
20positive regulation of isotype switching to IgG isotypesGO:00483049.7IFNG, IL4, IL2
21positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IFNG, TNF
22epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.7TNF, IL6
23negative regulation of growth of symbiont in hostGO:00441309.7TNF, IFNG
24negative regulation of lipid storageGO:00108889.7TNF, IL6
25negative regulation of smooth muscle cell proliferationGO:00486629.7IL15, IFNG
26positive regulation of osteoclast differentiationGO:00456729.7IFNG, TNF
27positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.6IL6, IL15
28protein import into nucleus, translocationGO:00000609.6IFNG, TNF
29positive regulation of chemokine productionGO:00327229.6TNF, IL6
30defense response to protozoanGO:00428329.6IL6, IL4, IFNG
31positive regulation of chemokine biosynthetic processGO:00450809.5TNF, IFNG, IL4
32defense response to Gram-positive bacteriumGO:00508309.4IL6, TNF
33extrinsic apoptotic signaling pathwayGO:00971919.4TNF, IFNG
34regulation of insulin secretionGO:00507969.4TNF, IFNG, NOS2
35positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.3IL6, IL4, TNF
36positive regulation of nitric oxide biosynthetic processGO:00454299.3IL6, IFNG, TNF
37cytokine-mediated signaling pathwayGO:00192219.3HLA-DQB1, HLA-DRB1, IFNG, IL6
38humoral immune responseGO:00069599.3IL6, IFNG, TNF
39negative regulation of fat cell differentiationGO:00455999.2TNF, IL6
40positive regulation of interferon-gamma productionGO:00327299.1IL2, TNF
41positive regulation of T cell proliferationGO:00421029.1IL6, IL15, IL4, IFNG
42response to drugGO:00424938.9TNF, IFNG, IL4, IL6
43immune responseGO:00069558.7IL15, IL2, IL4, HLA-DRB1, HLA-DQB1, MR1
44inflammatory responseGO:00069548.6TNF, LYZ, IL15, IL6, NOS2
45positive regulation of transcription from RNA polymerase II promoterGO:00459448.5TNF, IFNG, IL4, IL2, IL6

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.9HLA-DRB1, MR1
2MHC class II receptor activityGO:00323959.8HLA-DQB1, HLA-DRB1
3growth factor activityGO:00080838.9IL6, IL2, IL4
4cytokine activityGO:00051257.6IL6, IL15, IL2, IL4, IFNG, TNF

Products for genes affiliated with Microscopic Colitis

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Sources for Microscopic Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
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39NDF-RT
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43Novoseek
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50PubMed
51QIAGEN
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60UMLS
61UMLS via Orphanet