MCID: MCR191
MIFTS: 41

Microscopic Colitis malady

Gastrointestinal diseases, Rare diseases categories

Aliases & Classifications for Microscopic Colitis

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 42NCIt, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Microscopic Colitis:

Name: Microscopic Colitis 10 12 51
 
Colitis, Microscopic 65 36


Classifications:



Characteristics (Orphanet epidemiological data):

51
microscopic colitis:
Prevalence: 1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:0060182
MeSH36 D046728
NCIt42 C38504
ICD9CM29 558.9
Orphanet51 58220
ICD10 via Orphanet28 K52.8
MESH via Orphanet37 D046728
UMLS via Orphanet66 C0400821

Summaries for Microscopic Colitis

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Wikipedia:68 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

MalaCards based summary: Microscopic Colitis, also known as colitis, microscopic, is related to colitis and celiac disease. An important gene associated with Microscopic Colitis is CD79A (CD79a Molecule, Immunoglobulin-Associated Alpha), and among its related pathways are and Th1 Differentiation. Affiliated tissues include colon, t cells and thyroid, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Disease Ontology:10 A colitis that can only be diagnosed by the examination of colon tissue under a microscope.

Related Diseases for Microscopic Colitis

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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1colitis31.6CD79A, IFNG, IL2, IL4, TNF
2celiac disease30.5CD79A, HLA-DQB1, IL2
3asthma29.4CD79A, HLA-DQB1, IFNG, IL4, TNF
4diarrhea10.7
5collagenous colitis10.6
6irritable bowel syndrome10.6
7colonic disease10.5
8gastroenteritis10.5
9lymphocytic colitis10.4
10gastrointestinal system disease10.4
11intestinal disease10.4
12inflammatory diarrhea10.3
13acute allergic sanguinous otitis media10.3CD79A, IL2
14bagassosis10.3CD79A, IL2
15mechanical entropion10.3CD79A, IL2
16cervix endometrial stromal tumor10.3CD79A, IL2
17early myoclonic encephalopathy10.3CD79A, IL4
18visceral neuropathy familial10.3IL2, IL4
19iritis10.3CD79A, IFNG
20craniofacioskeletal syndrome10.3CD79A, IL4
21acute conjunctivitis10.3CD79A, IFNG
22ulcerative colitis10.3
23basal ganglia cerebrovascular disease10.3CD79A, IFNG
24acute apical periodontitis10.3IL2, IL4
25graft-versus-host disease, protection against10.3IFNG, IL2
26cd45 deficiency10.3IL2, IL4
27chronic hiccups10.3CD79A, IFNG
28myd88 deficiency10.3IFNG, IL4
29sensorineural hearing loss10.2IFNG, IL4
30sebaceous adenoma10.2IL2, IL4
31alternating exotropia10.2IFNG, IL4
32choroid disease10.2CD79A, HLA-DRB1
33xanthogranulomatous pyelonephritis10.2HLA-DRB1, IL2
34buruli ulcer10.2IFNG, IL4
35fibroosseous pseudotumor of digits10.2CD79A, LYZ
36hepatic tuberculosis10.2IL2, TNF
37chronic demyelinizing neuropathy with igm monoclonal10.2IFNG, IL2
38hyper-reninism10.2IFNG, IL4
39malignant sertoli-leydig cell tumor of ovary10.2IL2, TNF
40benign deep fibrous histiocytoma10.2IFNG, IL4
41disease of mental health10.2CD79A, LYZ
42neonatal urinary tract infectious disease10.2IFNG, IL4
43primary progressive freezing gait10.2IL4, TNF
44penis paget's disease10.2CD79A, IL4
45fallopian tube cystadenofibroma10.2CD79A, TNF
46intermediate cell type choroid melanoma10.2IL2, TNF
47primary lacrimal atrophy10.2HLA-DRB1, IL2
48conjunctivitis10.2CD79A, IL4
49intrapelvic lymph node leukemic reticuloendotheliosis10.2IL4, TNF
50acute pulmonary heart disease10.2CD79A, LYZ

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to microscopic colitis

Symptoms for Microscopic Colitis

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Drugs & Therapeutics for Microscopic Colitis

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Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
InfliximabapprovedPhase 4327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
2
BudesonideapprovedPhase 3, Phase 236851333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide Inhalation
Budesonide MMX
Budesonide Nasal
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
 
Horacort
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort FLEXHALER
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Uceris
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
3MesalaminePhase 2, Phase 314689-57-6
4Copolymer 1Phase 291
5
methylene blue67
Synonyms:
Urolene Blue
aniline violet
 
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
6Tolonium Chloride6
7
Bismuth967440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
8ColaNutraceutical1690

Interventional clinical trials:

(show all 25)
idNameStatusNCT IDPhase
1Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative ColitisCompletedNCT01408810Phase 4
2Trial of Mesalamine for the Treatment of Active Microscopic ColitisCompletedNCT00952952Phase 2, Phase 3
3Budesonide Treatment for Lymphocytic ColitisCompletedNCT00180050Phase 3
4Budesonide for Maintenance Treatment of Collagenous ColitisCompletedNCT00180076Phase 3
5SOIBD Collagenous Colitis Maintenance StudyCompletedNCT01278082Phase 3
6Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous ColitisCompletedNCT00450086Phase 3
7Budesonide for Induction of Remission in Incomplete Microscopic ColitisRecruitingNCT02142634Phase 3
8Budesonide Versus Mesalazine Versus Placebo in Lymphocytic ColitisRecruitingNCT01209208Phase 3
9Long-Term Treatment of Collagenous Colitis With BudesonideActive, not recruitingNCT00139165Phase 3
10Budesonide Versus Placebo for the Treatment of Lymphocytic ColitisTerminatedNCT00217022Phase 2, Phase 3
11A Double Blind Placebo Control Study to Assess the Safety,Tolerability and Efficacy of Copaxone in Crohn's DiseaseRecruitingNCT00731172Phase 2
12Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of TreatmentCompletedNCT01684514
13Endocytoscopy for in Vivo Determination of Mucosal Inflammatory Cells and Intestinal Disease Activity in Inflammatory Bowel Disease (IBD)CompletedNCT01289366
14Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
15Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS)RecruitingNCT01787253
16Ussing Experiments to Evaluate the Role of Medication-induced Microscopic ColitisRecruitingNCT02303132
17Early Detection of Tumors of the Digestive Tract by Confocal EndomicroscopyRecruitingNCT02284802
18Fecal Microbiota Transplantation for C Diff InfectionRecruitingNCT01905709
19Confocal Laser Endomicroscopy for Assessment of Mucosal Healing in Ulcerative ColitisRecruitingNCT02676817
20OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the AgesRecruitingNCT02523118
21The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel DiseaseRecruitingNCT02481687
22Utilization of NBi in Assessing Luminal INflammaion in IBD (UNBLIND)RecruitingNCT02049775
23Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal CancerActive, not recruitingNCT01075893
24Case-Control Study to Identify Risk Factors for Microscopic ColitisEnrolling by invitationNCT01928667
25Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Microscopic Colitis


Cochrane evidence based reviews: Colitis, Microscopic

Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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MalaCards organs/tissues related to Microscopic Colitis:

33
Colon, T cells, Thyroid, Bone, Small intestine

Animal Models for Microscopic Colitis or affiliated genes

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MGI Mouse Phenotypes related to Microscopic Colitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6CD79A, IFNG, IL2, IL4, TNF
2MP:00053818.4HLA-DQB1, IFNG, IL2, IL4, TNF
3MP:00053708.4HLA-DQB1, IFNG, IL2, IL4, TNF
4MP:00053888.2HLA-DQB1, IFNG, IL2, IL4, TNF
5MP:00053797.9HLA-DQB1, IFNG, IL2, IL4, SLC6A4, TNF
6MP:00053877.4CD79A, HLA-DQB1, IFNG, IL2, IL4, MR1
7MP:00053977.2CD79A, HLA-DQB1, IFNG, IL2, IL4, MR1

Publications for Microscopic Colitis

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Articles related to Microscopic Colitis:

(show top 50)    (show all 263)
idTitleAuthorsYear
1
Microscopic colitis that is not so microscopic. (25922142)
2015
2
P080. Persistence and sensitivity of colonic biopsies for microscopic colitis in a regional cohort. (25717537)
2015
3
Microscopic colitis: a misnomer for a clearly defined entity? (25961440)
2015
4
Microscopic colitis (lymphocytic and collagenous), eosinophilic colitis, and celiac disease. (26034409)
2015
5
OP010. Medication-induced microscopic colitis: do recency and duration of use matter? (25718276)
2015
6
Microscopic colitis: A review of etiology, treatment and refractory disease. (26269669)
2015
7
VSL#3 induces and maintains short-term clinical response in patients with active microscopic colitis: a two-phase randomised clinical trial. (26462271)
2015
8
Microscopic colitis. (25925924)
2015
9
Is microscopic colitis really microscopic? (25720998)
2015
10
Drug exposure and risk of microscopic colitis: a nationwide Danish case-control study with 5751 cases. (25153503)
2014
11
Microscopic colitis: Common cause of unexplained nonbloody diarrhea. (24891975)
2014
12
Microscopic Colitis - Clinical and Pathologic Perspectives. (24407107)
2014
13
Smoking- and alcohol habits in relation to the clinical picture of women with microscopic colitis compared to controls. (24456904)
2014
14
Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. (25665881)
2014
15
Microscopic colitis occurring in association with hyperplastic polyps and tubulovillous adenomas: observations in 10 cases. (25143518)
2014
16
Diagnosis and management of microscopic colitis: current perspectives. (25170275)
2014
17
Histology of Microscopic Colitis - Review with Practical Approach for Pathologists. (25381724)
2014
18
The Epidemiology of Microscopic Colitis in Olmsted County From 2002 to 2010: A Population-Based Study. (24120840)
2013
19
Microscopic colitis: a therapeutic challenge. (23801853)
2013
20
Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. (23600961)
2013
21
Microscopic colitis patients have increased proportions of Ki67(+) proliferating and CD45RO(+) active/memory CD8(+) and CD4(+)8(+) mucosal T cells. (22995775)
2013
22
Is microscopic colitis a drug-induced disease? (23060216)
2012
23
Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group. (22704658)
2012
24
Decreased colorectal cancer and adenoma risk in patients with microscopic colitis. (21847567)
2012
25
Clinical course of microscopic colitis in a single-center cohort study. (21575884)
2011
26
Microscopic colitis: clinical findings, topography and persistence of histopathological subgroups. (21967618)
2011
27
Efficacy of anti-TNF therapies in refractory severe microscopic colitis. (22115383)
2011
28
Cytokine gene polymorphism in microscopic colitis association with the IL-6-174 GG genotype. (21527852)
2011
29
Microscopic colitis. (21303675)
2011
30
Low bone mass in microscopic colitis. (21595910)
2011
31
Patients with drug-induced microscopic colitis should not be included in controlled trials assessing the efficacy of anti-inflammatory drugs in microscopic colitis. (19717133)
2009
32
Microscopic colitis: a review for the surgical endoscopist. (19865548)
2009
33
Microscopic colitis and endoscopy. (19841492)
2009
34
Microscopic colitis: a common and an easily overlooked cause of chronic diarrhoea. (18395161)
2008
35
Diagnosis and management of microscopic colitis. (19109861)
2008
36
Microscopic colitis with giant cells: a clinico-pathological review of 11 cases and comparison with microscopic colitis without giant cells. (18985521)
2008
37
Clozapine-induced microscopic colitis: a case report and review of the literature. (18004122)
2007
38
The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. (17135309)
2007
39
How much symptom overlap is there between microscopic colitis and IBS? (17438567)
2007
40
Drug consumption and the risk of microscopic colitis. (17100977)
2007
41
Autoantibody profiles in microscopic colitis. (16724988)
2006
42
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. (15641395)
2004
43
Microscopic colitis with giant cells: a rare new histopathologic subtype? (14765272)
2004
44
Microscopic colitis. (12744549)
2003
45
Lansoprazole-associated microscopic colitis: a case series. (12425567)
2002
46
Postcholecystectomy microscopic colitis: is bile acid malabsorption a triggering factor? (11374729)
2001
47
Microscopic colitis syndrome. (7615277)
1995
48
Association of lymphocytic (microscopic) colitis with tropical sprue. (8155860)
1994
49
Response to treatment of microscopic colitis. (7919463)
1994
50
Microscopic colitis, collagenous colitis, and mast cells. (2364851)
1990

Variations for Microscopic Colitis

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Expression for genes affiliated with Microscopic Colitis

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Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for genes affiliated with Microscopic Colitis

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Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
AhR pathway (WikiPathways)
Show member pathways
9.7
2
Show member pathways
9.1IFNG, IL2, TNF
3
Show member pathways
9.1IFNG, IL2, TNF
49.1IFNG, IL2, TNF
5
Show member pathways
9.1IFNG, IL2, TNF
6
Show member pathways
9.0IFNG, IL4, TNF
78.9IFNG, IL2, IL4
8
Show member pathways
8.9IFNG, IL2, IL4
98.9IFNG, IL2, IL4
108.9IFNG, IL2, IL4
11
Show member pathways
8.9HLA-DQB1, HLA-DRB1, IL2
128.8HLA-DRB1, IL4, TNF
138.7HLA-DQB1, HLA-DRB1, IFNG
148.6HLA-DRB1, IFNG, IL2
15
Show member pathways
8.6IFNG, IL2, IL4, TNF
16
Show member pathways
8.6IFNG, IL2, IL4, TNF
178.6IFNG, IL2, IL4, TNF
18
Show member pathways
8.6IFNG, IL2, IL4, TNF
198.5HLA-DQB1, HLA-DRB1, IL2, TNF
208.3HLA-DQB1, HLA-DRB1, IFNG, TNF
218.3HLA-DQB1, HLA-DRB1, IFNG, TNF
22
B cell receptor signaling pathway (KEGG)
Show member pathways
8.3HLA-DQB1, HLA-DRB1, IFNG, TNF
238.3CD79A, IFNG, IL2, IL4, TNF
24
Show member pathways
8.1HLA-DRB1, IFNG, IL2, IL4
25
Show member pathways
7.8HLA-DQB1, HLA-DRB1, IFNG, IL4, TNF
267.8HLA-DRB1, IFNG, IL2, IL4, TNF
27
Show member pathways
7.4HLA-DQB1, HLA-DRB1, IFNG, IL2, IL4, TNF
28
Show member pathways
7.4HLA-DQB1, HLA-DRB1, IFNG, IL2, IL4, TNF
29
Show member pathways
7.1CD79A, HLA-DQB1, HLA-DRB1, IFNG, IL2, IL4

GO Terms for genes affiliated with Microscopic Colitis

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Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.8HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.8HLA-DQB1, HLA-DRB1
3membrane raftGO:00451219.2CD79A, SLC6A4, TNF
4external side of plasma membraneGO:00098978.3CD79A, HLA-DRB1, IFNG, IL4, TNF
5extracellular regionGO:00055767.6IFNG, IL2, IL4, LYZ, MR1, TNF

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mononuclear cell migrationGO:007167710.2IL4, TNF
2positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1IL2, IL4
5positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IFNG, TNF
6protein import into nucleus, translocationGO:000006010.1IFNG, TNF
7B cell activationGO:004211310.1CD79A, IL4
8positive regulation of activated T cell proliferationGO:004210410.0IL2, IL4
9positive regulation of T cell differentiationGO:004558210.0IL2, IL4
10antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.9HLA-DQB1, HLA-DRB1
11positive regulation of MHC class II biosynthetic processGO:00453489.9IFNG, IL4
12negative regulation of growth of symbiont in hostGO:00441309.9IFNG, TNF
13immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.9HLA-DQB1, HLA-DRB1
14positive regulation of osteoclast differentiationGO:00456729.8IFNG, TNF
15humoral immune response mediated by circulating immunoglobulinGO:00024559.8HLA-DQB1, HLA-DRB1
16defense response to protozoanGO:00428329.8IFNG, IL4
17positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL4, TNF
18adaptive immune responseGO:00022509.5CD79A, IFNG, IL2
19positive regulation of protein phosphorylationGO:00019349.5IL2, IL4, TNF
20positive regulation of isotype switching to IgG isotypesGO:00483049.4IFNG, IL2, IL4
21interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DQB1, HLA-DRB1, IFNG
22positive regulation of T cell proliferationGO:00421028.9IFNG, IL2, IL4
23defense response to bacteriumGO:00427428.7IFNG, LYZ, TNF
24antigen processing and presentationGO:00198828.6HLA-DQB1, HLA-DRB1, IFNG, MR1
25immune responseGO:00069557.0HLA-DQB1, HLA-DRB1, IFNG, IL2, IL4, MR1

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.7HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426058.8HLA-DQB1, HLA-DRB1, MR1
3cytokine activityGO:00051258.3IFNG, IL2, IL4, TNF

Sources for Microscopic Colitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet