MPA
MCID: MCR088
MIFTS: 53

Microscopic Polyangiitis (MPA) malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Cardiovascular diseases categories

Summaries for Microscopic Polyangiitis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Microscopic polyangiitis (mpa) is a disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. the kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. mpa is diagnosed in people of all ages, all ethnicities, and both genders. the cause of this disorder is unknown. last updated: 2/4/2009

MalaCards: Microscopic Polyangiitis, also known as microscopic polyarteritis, is related to wegener's granulomatosis and churg-strauss syndrome, and has symptoms including heart/cardiac failure, cutis marmorata/marbled skin/livedo and nasal congestion/sinusitis/rhinitis/rhinorrhea. An important gene associated with Microscopic Polyangiitis is KIR2DS3 (killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3), and among its related pathways are Rheumatoid arthritis and Allograft rejection. The compounds valine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:63 Microscopic polyangiitis (also known as \"Microscopic polyarteritis,\" \"Microscopic polyarteritis... more...

Aliases & Classifications for Microscopic Polyangiitis

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
microscopic polyangiitis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

microscopic polyangiitis 42 48 60
microscopic polyarteritis 48 60
vasculitis, leukocytoclastic, cutaneous 60
hypersensitivity angiitis 48
micropolyangiitis 48
mpa 48


External Ids:

MESH via Orphanet35 D055953
ICD10 via Orphanet26 M31.7
UMLS via Orphanet61 C0343192
SNOMED-CT via Orphanet57 60555002
ICD1025 M31.0, M31.7

Related Diseases for Microscopic Polyangiitis

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17GeneCards, 18GeneDecks
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Diseases related to Microscopic Polyangiitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1wegener's granulomatosis31.3PRTN3, MPO, CTLA4, SELE
2churg-strauss syndrome31.1MPO, PRTN3
3vasculitis31.0FCGR3B, PRTN3, MPO, CTLA4, SELE, TNFRSF1B
4pulmonary fibrosis30.7MPO
5glomerulonephritis30.7FCGR2A, PRTN3, MPO
6neuropathy30.6MB
7hepatitis30.5GGT1, CTLA4
8breast cancer30.5TNFRSF1B, CTLA4, PRTN3, KIR3DL1
9influenza30.4MB
10endocarditis30.3PRTN3
11pancreatitis30.3MPO, GGT1
12primary biliary cirrhosis30.3HLA-DRB1, CTLA4, GGT1, PRTN3
13graft versus host disease30.3HLA-DRB1, CTLA4, KIR3DL1, IL2RA
14lupus erythematosus30.0FCGR2B
15antiphospholipid syndrome30.0SELE
16systemic lupus erythematosus30.0FCGR2A, FCGR3B
17rapidly progressive glomerulonephritis30.0MPO, PRTN3
18hypersensitivity vasculitis30.0MPO, PRTN3, FCGR3B
19disseminated intravascular coagulation30.0MB
20scleritis30.0PRTN3
21thyroiditis30.0CTLA4, HLA-DRB1
22myasthenia gravis30.0CTLA4, HLA-DQB1, FCGR2A
23pneumonia30.0MPO, MB, TNFRSF1B
24hepatitis c30.0GGT1, TNFRSF1B, CTLA4, HLA-DRB1
25autoimmune hepatitis30.0GGT1, HLA-DRB1, CTLA4, HLA-DQB1
26tuberculosis30.0IL2RA, CX3CL1, TNFRSF1B, HLA-DQB1, HLA-DRB1
27asthma30.0FCGR3B, IL2RA, PRTN3, SELE, MPO, CTLA4
28arthritis30.0FCGR3B, FCGR3A, FCGR2A, FCGR2B, PRTN3, MPO
29cholangitis30.0GGT1
30rheumatoid arthritis30.0KIR2DL1, IL2RA, CX3CL1, PRTN3, MPO, HLA-DRB1
31polyarteritis nodosa10.8
32cerebritis10.3
33purpura10.3
34peripheral neuropathy10.3
35cutaneous necrotizing vasculitis10.2
36hepatitis a10.2
37amyloidosis10.2
38kidney disease10.2
39allergic cutaneous vasculitis10.1
40crescentic glomerulonephritis10.0
41cardiac tamponade10.0
42hereditary hemorrhagic telangiectasia10.0
43iga glomerulonephritis10.0
44relapsing polychondritis10.0
45pulmonary systemic sclerosis10.0
46autoimmune thyroiditis10.0
47idiopathic pulmonary fibrosis10.0
48sensorineural hearing loss10.0
49coronary aneurysm10.0
50henoch-schoenlein purpura10.0

Graphical network of the top 20 diseases related to Microscopic Polyangiitis:



Diseases related to microscopic polyangiitis

Clinical Features for Microscopic Polyangiitis

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Sources:
48Orphanet
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Symptoms:

48 (show all 39)
  • heart/cardiac failure
  • cutis marmorata/marbled skin/livedo
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • retinal vascular anomalies/retinal telangiectasia
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • articular/joint pain/arthralgia
  • myalgia/muscular pain
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pancreatitis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • gangrena/necrosis
  • peripheral neuropathy
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • arthritis/synovitis/synovial proliferation
  • epistaxis/nose bleeding
  • mesenteric/intestinal infarction
  • venous thrombosis/phlebitis/thrombophlebitis
  • neuritis/polyneuritis/multineuritis
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • hematuria/microhematuria
  • renal failure
  • renal glomerular defect/glomerulopathy
  • vascularitis/vasculitides/arteritis
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • hemoptysis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • autoimmunity/autoimmune reaction/autoantibodies
  • fever/chilling
  • peritonitis/peritoneal abscess
  • intestinal perforation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute diarrhea
  • acute abdominal pain/colic
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • purpura/petichiae
  • chronic skin infection/ulcerations/ulcers/cancrum
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • cutaneous rash

Drugs & Therapeutics for Microscopic Polyangiitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Microscopic Polyangiitis

Drug clinical trials:

Search ClinicalTrials for Microscopic Polyangiitis

Search NIH Clinical Center for Microscopic Polyangiitis

Search CenterWatch for Microscopic Polyangiitis

Genetic Tests for Microscopic Polyangiitis

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Anatomical Context for Microscopic Polyangiitis

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32MalaCards
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MalaCards organs/tissues related to Microscopic Polyangiitis:

32
Skin, Lung, Kidney, Heart, Bone

Animal Models for Microscopic Polyangiitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Microscopic Polyangiitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7SELE, MB, CTLA4, TNFRSF1B, HLA-DQB1, MPO
2MP:00053767.9GGT1, MB, TNFRSF1B, CTLA4, HLA-DQB1, MPO
3MP:00053977.8MB, GGT1, FCGR2B, IL2RA, CX3CL1, MPO
4MP:00053877.7FCGR3A, FCGR2B, IL2RA, CX3CL1, PRTN3, MPO

Publications for Microscopic Polyangiitis

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Genetic Variations for Microscopic Polyangiitis

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Expression for genes affiliated with Microscopic Polyangiitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microscopic Polyangiitis

Search GEO for disease gene expression data for Microscopic Polyangiitis.

Pathways for genes affiliated with Microscopic Polyangiitis

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CTLA4
2
Hide members
10.0KIR2DS3, KIR2DL1, KIR3DL1
39.9FCGR2B, FCGR2A, FCGR3A
4
Hide members
9.9FCGR2A, FCGR3B, FCGR2B
5
Hide members
9.7HLA-DRB1, HLA-DQB1, CTLA4
69.7TNFRSF1B, CX3CL1, SELE
79.7HLA-DQB1, HLA-DRB1, IL2RA
8
Hide members
9.6FCGR2B, KIR2DL1, FCGR2A, KIR3DL1, FCGR3A
9
Hide members
9.5HLA-DRB1, FCGR2B, HLA-DQB1, IL2RA
10
Hide members
9.5IL2RA, FCGR2B, HLA-DRB1, HLA-DQB1
119.5HLA-DQB1, CTLA4, HLA-DRB1, SELE
12
Hide members
9.5CTLA4, HLA-DRB1, IL2RA, HLA-DQB1
13
Hide members
9.5KIR2DL1, KIR2DS3, KIR3DL1, FCGR3B, FCGR2B, FCGR3A
14
Hide members
9.5KIR2DL1, FCGR3A, FCGR2A, FCGR2B, KIR3DL1, KIR3DS1
159.4FCGR3A, FCGR2A, FCGR3B, LILRA2, FCGR2B
16
Hide members
9.4FCGR2A, FCGR3A, FCGR3B, HLA-DRB1, HLA-DQB1
17
Hide members
9.4HLA-DRB1, FCGR2A, FCGR3A, FCGR3B, HLA-DQB1
18
Hide members
9.3HLA-DRB1, CTLA4, HLA-DQB1, TNFRSF1B, IL2RA
199.2FCGR3A, FCGR2A, HLA-DRB1, FCGR2B, FCGR3B, HLA-DQB1
209.2HLA-DRB1, FCGR3A, HLA-DQB1, FCGR2A, FCGR2B, FCGR3B
219.1HLA-DQB1, HLA-DRB1, MPO, FCGR3B, FCGR2B, FCGR3A

Compounds for genes affiliated with Microscopic Polyangiitis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1valine4410.7MB
2glutamate4410.2CX3CL1, MB
3Palivizumab1110.2FCGR3A, FCGR2B, FCGR3B, FCGR2A
4Intravenous Immunoglobulin1110.2FCGR3A, FCGR2A, FCGR2B, FCGR3B
5Ibritumomab1110.2FCGR3B, FCGR2A, FCGR3A, FCGR2B
6bevacizumab49 1111.2FCGR2B, FCGR3B, FCGR3A, FCGR2A
7tositumomab49 1111.2FCGR2A, FCGR2B, FCGR3B, FCGR3A
8alefacept44 1111.2FCGR3A, FCGR2A, FCGR2B, FCGR3B
9Muromonab1110.2FCGR3B, FCGR2B, FCGR2A, FCGR3A
10efalizumab44 1111.1FCGR2A, FCGR3A, FCGR3B, FCGR2B
11gemtuzumab ozogamicin44 1111.1FCGR3B, FCGR2B, FCGR2A, FCGR3A
12adalimumab44 49 1112.1FCGR2A, FCGR3A, FCGR3B, FCGR2B
13abciximab44 1111.1FCGR2A, FCGR3B, FCGR2B, FCGR3A
14cetuximab44 49 1112.1FCGR3A, FCGR2B, FCGR2A, FCGR3B
15n-(2-mercaptopropionyl)glycine4410.1MPO, MB
16trastuzumab44 49 1112.1FCGR2A, FCGR2B, FCGR3B, FCGR3A
17gold sodium thiomalate4410.1SELE, IL2RA, HLA-DRB1
18fitc4410.1TNFRSF1B, FCGR2B, IL2RA
19nadph44 2411.0PRTN3, FCGR2A
20sulfasalazine44 28 49 1113.0SELE, IL2RA, MPO
21con a4410.0TNFRSF1B, CTLA4, IL2RA
22polyethylene glycol4410.0MB, TNFRSF1B, SELE, MPO
23etanercept44 49 1112.0FCGR3A, TNFRSF1B, FCGR3B, FCGR2B, FCGR2A
24daclizumab44 1111.0FCGR3B, FCGR3A, FCGR2A, FCGR2B, IL2RA
25basiliximab44 1110.9FCGR3A, FCGR2A, FCGR2B, FCGR3B, IL2RA
26natalizumab44 1110.9FCGR3B, FCGR3A, FCGR2A, IL2RA, FCGR2B
27alemtuzumab44 1110.9FCGR2A, FCGR3B, IL2RA, FCGR3A, FCGR2B
28infliximab44 49 1111.9TNFRSF1B, SELE, IL2RA, PRTN3
29ivig449.9IL2RA, TNFRSF1B, FCGR2B, FCGR2A, FCGR3A
30prednisolone44 28 1111.8MB, FCGR2A, FCGR3B, IL2RA, MPO
31clozapine44 28 49 1112.8TNFRSF1B, MPO, GGT1, IL2RA
32mycophenolate mofetil44 49 1111.8IL2RA, GGT1, CTLA4, SELE
33methimazole44 2 1111.8MPO, IL2RA, SELE
34heparin44 28 11 2412.7IL2RA, MB, MPO, FCGR2A, SELE
35histamine44 28 2411.7SELE, FCGR2A, FCGR2B, IL2RA, MPO
36formaldehyde44 2410.6PRTN3, IL2RA, SELE, MPO
37h2o2449.6TNFRSF1B, FCGR2A, MPO, MB, IL2RA, FCGR3B
38n acetylcysteine449.6MPO, MB, IL2RA, GGT1, SELE
39fmlp449.5PRTN3, FCGR3B, MPO, FCGR2B, TNFRSF1B, FCGR2A
40polysaccharide449.5SELE, GGT1, FCGR2A, FCGR3B, IL2RA
41acetylcholine44 49 28 11 2413.5GGT1, MPO, IL2RA, MB, CTLA4
42lysine449.5KIR3DL1, TNFRSF1B, CTLA4, HLA-DRB1, IL2RA, FCGR2A
43rituximab44 49 1111.5FCGR3A, PRTN3, IL2RA, FCGR3B, FCGR2B, FCGR2A
44cholesterol44 28 11 2412.2TNFRSF1B, CTLA4, FCGR2A, FCGR3A, GGT1, SELE
45methotrexate44 49 1111.2IL2RA, HLA-DRB1, CTLA4, TNFRSF1B, GGT1, SELE
46arginine449.2TNFRSF1B, MB, FCGR2A, FCGR3A, IL2RA, HLA-DRB1
47genistein44 28 59 2 11 2414.0FCGR2B, FCGR3B, IL2RA, PRTN3, SELE
48serine449.0SELE, PRTN3, FCGR2A, FCGR2B, MB, MPO
49lipid448.7PRTN3, KIR3DL1, KIR2DL1, FCGR2B, GGT1, CTLA4
50tyrosine448.4KIR3DL1, IL2RA, TNFRSF1B, CTLA4, HLA-DQB1, FCGR2A

GO Terms for genes affiliated with Microscopic Polyangiitis

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16Gene Ontology
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Cellular components related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DQB1
2external side of plasma membraneGO:0098979.5CTLA4, HLA-DRB1, IL2RA, FCGR3A
3integral to plasma membraneGO:0058879.1CTLA4, HLA-DRB1, KIR2DL1, KIR2DS3, KIR3DS1, KIR3DL1
4plasma membraneGO:0058866.9SELE, TNFRSF1B, CTLA4, HLA-DQB1, HLA-DRB1, PRTN3

Biological processes related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DQB1, HLA-DRB1
2inflammatory response to antigenic stimulusGO:00243710.0HLA-DRB1, IL2RA
3regulation of immune responseGO:0507769.9FCGR3A, FCGR2B, KIR3DL1, KIR2DL1
4defense responseGO:0069529.7CX3CL1, MPO, LILRA2
5humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DRB1, HLA-DQB1
6T cell costimulationGO:0312959.6CTLA4, HLA-DQB1, HLA-DRB1
7immune responseGO:0069558.1KIR2DL1, KIR3DS1, KIR3DL1, FCGR3B, FCGR2B, FCGR3A

Molecular functions related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB1
2IgG bindingGO:0198649.4FCGR3A, FCGR2A, FCGR2B, FCGR3B

Products for genes affiliated with Microscopic Polyangiitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Microscopic Polyangiitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet