MPA
MCID: MCR088
MIFTS: 49

Microscopic Polyangiitis (MPA) malady

Categories: Rare diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Microscopic Polyangiitis

Aliases & Descriptions for Microscopic Polyangiitis:

Name: Microscopic Polyangiitis 50 56
Microscopic Polyarteritis 56 69
Micropolyangiitis 56
Mpa 56

Characteristics:

Orphanet epidemiological data:

56
microscopic polyangiitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/1000000 (Germany),1-9/1000000 (Norway),1-9/100000 (United Kingdom),1-9/100000 (Germany),1-9/100000 (Australia),1-9/100000 (Japan),1-9/100000 (Kuwait),1-9/1000000 (Canada),1-9/100000 (Greece),1-9/1000000 (Lithuania),1-9/100000 (Sweden); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 56 ORPHA727
ICD10 via Orphanet 34 M31.7
MESH via Orphanet 43 D055953
UMLS via Orphanet 70 C0343192
ICD10 33 M31.7

Summaries for Microscopic Polyangiitis

NIH Rare Diseases : 50 microscopic polyangiitis (mpa) is a disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. the kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. mpa is diagnosed in people of all ages, all ethnicities, and both genders. the cause of this disorder is unknown. last updated: 8/13/2014

MalaCards based summary : Microscopic Polyangiitis, also known as microscopic polyarteritis, is related to hepatitis and goodpasture syndrome, and has symptoms including arthralgia, myalgia and fever. An important gene associated with Microscopic Polyangiitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Wikipedia : 71 Microscopic polyangiitis is an ill-defined autoimmune disease characterized by a systemic, pauci-immune,... more...

Related Diseases for Microscopic Polyangiitis

Diseases related to Microscopic Polyangiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.2 HLA-B HLA-DRB1 KIR3DL1 TNF
2 goodpasture syndrome 29.0 HLA-B KIR3DL1 TNF
3 anca-associated vasculitis 10.9
4 polyarteritis nodosa 10.3
5 vasculitis 10.3
6 churg-strauss syndrome 10.2
7 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.2 MPO TNF
8 uveitis 10.2 MPO TNF
9 parkinson disease 11 10.2 MPO TNF
10 sacral nerve root cysts 10.2 HLA-B HLA-DRB1
11 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DRB1 TNF
12 dermatomycosis 10.2 MPO TNF
13 immune deficiency, familial variable 10.2 HLA-B HLA-DRB1
14 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DRB1 TNF
15 distal trisomy 14q 10.2 HLA-DRB1 TNF
16 scalp dermatosis 10.2 MPO TNF
17 hernia of ovary and fallopian tube 10.2 HLA-B HLA-DRB1
18 grix blankenship peterson syndrome 10.2 MPO TNF
19 learning disability 10.2 HLA-B HLA-DRB1
20 kernicterus due to isoimmunization 10.2 HLA-DRB1 TNF
21 human immunodeficiency virus infectious disease 10.2 HLA-DRB1 TNF
22 cervical adenoid basal carcinoma 10.2 HLA-B HLA-DRB1
23 clostridium difficile colitis 10.2 HLA-DRB1 TNF
24 astrocytoma 10.2 MPO TNF
25 right ventricle hypoplasia 10.2 HLA-DRB1 TNF
26 crohn's colitis 10.1 MPO TNF
27 acanthoma 10.1 HLA-B HLA-DRB1
28 pancreatic signet ring cell adenocarcinoma 10.1 HLA-DRB1 TNF
29 urticaria 10.1 MPO TNF
30 strawberry gallbladder 10.1 MPO TNF
31 bickerstaff brainstem encephalitis 10.1 HLA-B HLA-DRB1
32 hereditary alpha tryptasemia syndrome 10.1 HLA-DRB1 TNF
33 anaerobic meningitis 10.1 HLA-B HLA-DRB1
34 aortic coarctation 10.1 HLA-B TNF
35 benign deep fibrous histiocytoma 10.1 HLA-DRB1 TNF
36 motility-related diarrhea 10.1 HLA-DRB1 TNF
37 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 HLA-B TNF
38 cyclosporiasis 10.1 HLA-B TNF
39 endogenous depression 10.1 HLA-DRB1 TNF
40 plummer's disease 10.1 HLA-DRB1 TNF
41 low anorectal malformation 10.1 HLA-DRB1 TNF
42 gonococcal endophthalmia 10.1 HLA-B TNF
43 patau syndrome 10.1 HLA-DRB1 TNF
44 pericholangitis 10.1 MPO TNF
45 peripheral artery disease 10.1 HLA-DRB1 TNF
46 pulmonary hemosiderosis 10.1 HLA-DRB1 TNF
47 chordoid meningioma 10.1 MPO TNF
48 pulmonary fibrosis 10.1
49 orbital osteomyelitis 10.1 HLA-B TNF
50 immunoglobulin g deficiency 10.1 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Microscopic Polyangiitis:



Diseases related to Microscopic Polyangiitis

Symptoms & Phenotypes for Microscopic Polyangiitis

Human phenotypes related to Microscopic Polyangiitis:

56 32 (show all 37)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Frequent (79-30%) HP:0002829
2 myalgia 56 32 Frequent (79-30%) HP:0003326
3 fever 56 32 Very frequent (99-80%) HP:0001945
4 hemoptysis 56 32 Very frequent (99-80%) HP:0002105
5 abdominal pain 56 32 Frequent (79-30%) HP:0002027
6 diarrhea 56 32 Frequent (79-30%) HP:0002014
7 nausea and vomiting 56 32 Frequent (79-30%) HP:0002017
8 arthritis 56 32 Occasional (29-5%) HP:0001369
9 renal insufficiency 56 32 Very frequent (99-80%) HP:0000083
10 subcutaneous nodule 56 32 Occasional (29-5%) HP:0001482
11 arrhythmia 56 32 Occasional (29-5%) HP:0011675
12 sinusitis 56 32 Occasional (29-5%) HP:0000246
13 congestive heart failure 56 32 Occasional (29-5%) HP:0001635
14 autoimmunity 56 32 Very frequent (99-80%) HP:0002960
15 venous thrombosis 56 32 Frequent (79-30%) HP:0004936
16 skin ulcer 56 32 Frequent (79-30%) HP:0200042
17 pancreatitis 56 32 Occasional (29-5%) HP:0001733
18 paresthesia 56 32 Occasional (29-5%) HP:0003401
19 glomerulopathy 56 32 Very frequent (99-80%) HP:0100820
20 abnormality of the retinal vasculature 56 32 Occasional (29-5%) HP:0008046
21 hematuria 56 32 Very frequent (99-80%) HP:0000790
22 gastrointestinal hemorrhage 56 32 Frequent (79-30%) HP:0002239
23 erythema 56 32 Very frequent (99-80%) HP:0010783
24 epistaxis 56 32 Occasional (29-5%) HP:0000421
25 pericarditis 56 32 Occasional (29-5%) HP:0001701
26 skin rash 56 32 Very frequent (99-80%) HP:0000988
27 vasculitis 56 32 Very frequent (99-80%) HP:0002633
28 subcutaneous hemorrhage 56 32 Frequent (79-30%) HP:0001933
29 gastrointestinal infarctions 56 32 Frequent (79-30%) HP:0005244
30 gangrene 56 32 Occasional (29-5%) HP:0100758
31 cutis marmorata 56 32 Occasional (29-5%) HP:0000965
32 peritonitis 56 32 Frequent (79-30%) HP:0002586
33 uveitis 56 32 Occasional (29-5%) HP:0000554
34 episcleritis 56 32 Occasional (29-5%) HP:0100534
35 oliguria 56 32 Very frequent (99-80%) HP:0100520
36 peripheral neuropathy 56 Occasional (29-5%)
37 increased inflammatory response 56 Very frequent (99-80%)

Drugs & Therapeutics for Microscopic Polyangiitis

Drugs for Microscopic Polyangiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
4
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
5
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
6
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
7
alemtuzumab Approved, Investigational Phase 4 216503-57-0
8
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
10
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
11
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
13 Alkylating Agents Phase 4,Phase 3,Phase 2
14 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
15 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
16 Dermatologic Agents Phase 4,Phase 3,Phase 2
17 Vitamin B Complex Phase 4,Phase 3,Phase 2
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Antimetabolites Phase 4,Phase 3,Phase 2
21 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
22 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
23 Antirheumatic Agents Phase 4,Phase 3,Phase 2
24 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2
25 Prednisolone acetate Phase 4,Phase 2,Phase 3
26 glucocorticoids Phase 4,Phase 2,Phase 3
27 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
28 Neuroprotective Agents Phase 4,Phase 2,Phase 3
29 Hormone Antagonists Phase 4,Phase 2,Phase 3
30 Hormones Phase 4,Phase 2,Phase 3
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
33 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
34 Prednisolone phosphate Phase 4,Phase 2,Phase 3
35 Protective Agents Phase 4,Phase 2,Phase 3
36 Antiemetics Phase 4,Phase 2,Phase 3
37 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
38 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
39 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
40 Autonomic Agents Phase 4,Phase 2,Phase 3
41 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
42 Tin Fluorides Phase 4
43 Folate Nutraceutical Phase 4,Phase 3,Phase 2
44 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
45
belimumab Approved Phase 3 356547-88-1 5957 10451420
46
Acetaminophen Approved Phase 3 103-90-2 1983
47 Immunoglobulins Phase 3,Phase 2
48 Antibodies Phase 3,Phase 2
49 Antibodies, Antineutrophil Cytoplasmic Phase 3,Phase 2
50 Dexchlorpheniramine Phase 3

Interventional clinical trials:

(show all 49)
id Name Status NCT ID Phase
1 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4
2 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4
3 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4
4 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Recruiting NCT02115997 Phase 4
5 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4
6 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Active, not recruiting NCT02169219 Phase 4
7 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3
8 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3
9 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3
10 Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis Completed NCT00104299 Phase 2, Phase 3
11 Belimumab in Remission of VASculitis Completed NCT01663623 Phase 3
12 Efficacy Study of Two Treatments in the Remission of Vasculitis Completed NCT00748644 Phase 3
13 Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3
14 Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis Active, not recruiting NCT00987389 Phase 3
15 Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis Active, not recruiting NCT01731561 Phase 3
16 Rituximab Vasculitis Maintenance Study Active, not recruiting NCT01697267 Phase 3
17 Comparison Between a Long Term and a Conventional Maintenance Treatment With Rituximab Active, not recruiting NCT02433522 Phase 3
18 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3
19 Plasma Exchange for Renal Vasculitis Terminated NCT01408836 Phase 2, Phase 3
20 IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis Terminated NCT00307645 Phase 3
21 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2
22 Anti-Cytokine Therapy for Vasculitis Completed NCT00753103 Phase 2
23 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2
24 A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis Active, not recruiting NCT01750697 Phase 2
25 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2
26 BIANCA-SC: A Study of the Efficacy, Safety, and Tolerability of Blisibimod in Addition to Methotrexate During Induction of Remission in Subjects With ANCA-Associated Small Vessel Vasculitis Withdrawn NCT01598857 Phase 2
27 CellCept in p-ANCA Vasculitis Completed NCT00405860 Phase 1
28 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1
29 Rituximab for ANCA-associated Vasculitis (RAVE) Long-Term Follow-Up Study Unknown status NCT01586858
30 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
31 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593
32 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
33 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
34 Impact of Vasculitis on Employment and Income Completed NCT02476292
35 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
36 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
37 Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis Recruiting NCT00315393
38 Pharmacokinetic Study of Rituximab Induction Regimen in ANCA-associated Vasculitis Recruiting NCT02474888
39 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Recruiting NCT01066208
40 Pediatric Vasculitis Initiative Recruiting NCT02006134
41 One-Time DNA Study for Vasculitis Recruiting NCT01241305
42 VCRC Tissue Repository Recruiting NCT02967068
43 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
44 Vasculitis Pregnancy Registry Recruiting NCT02593565
45 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Recruiting NCT01862068
46 An Observational Study of The Safety of MabThera/Rituxan (Rituximab) in Patients With Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis Active, not recruiting NCT01613599
47 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Active, not recruiting NCT01663129
48 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
49 Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis Not yet recruiting NCT02126098

Search NIH Clinical Center for Microscopic Polyangiitis

Genetic Tests for Microscopic Polyangiitis

Anatomical Context for Microscopic Polyangiitis

MalaCards organs/tissues related to Microscopic Polyangiitis:

39
Skin, Lung, Kidney, Neutrophil, Bone, Heart, Breast

Publications for Microscopic Polyangiitis

Articles related to Microscopic Polyangiitis:

(show top 50) (show all 379)
id Title Authors Year
1
IgM Antibodies to Proteinase 3 in Granulomatosis with Polyangiitis and Microscopic Polyangiitis. ( 28076879 )
2017
2
Evaluation of automated multi-parametric indirect immunofluorescence assays to detect anti-neutrophil cytoplasmic antibodies (ANCA) in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). ( 26970486 )
2016
3
Comparing presenting clinical features of 48 children with microscopic polyangiitis (MPA) against 183 having granulomatosis with polyangiitis (GPA). An ARChiVe study. ( 27111558 )
2016
4
Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis. ( 26864299 )
2016
5
Predictive factors for mortality in elderly Japanese patients with severe microscopic polyangiitis: A retrospective single-center study. ( 27400379 )
2016
6
Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report. ( 27186376 )
2016
7
Very early renal relapse of microscopic polyangiitis after kidney transplantation. ( 27118023 )
2016
8
Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study. ( 27166610 )
2016
9
Bilateral Scleritis and Retinal Vasculitis in Microscopic Polyangiitis. ( 27871395 )
2016
10
Successful Immunosuppressive Treatment of Mixed Connective Tissue Disease Complicated by Microscopic Polyangiitis. ( 27238624 )
2016
11
Chronic and Asymptomatic Diffuse Alveolar Haemorrhage with Microscopic Polyangiitis: A Case Report and Review of the Literature. ( 28050304 )
2016
12
Childhood-onset granulomatosis with polyangiitis and microscopic polyangiitis: systematic review and meta-analysis. ( 27770813 )
2016
13
Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis. ( 26833773 )
2016
14
Long-term outcome of mycophenolate mofetil treatment for patients with microscopic polyangiitis: an observational study in Chinese patients. ( 27169414 )
2016
15
Microscopic polyangiitis presenting with multiple punched-out ulcers: A case report. ( 27177686 )
2016
16
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
17
Ultra-Wide-Field Fluorescein Angiography in Microscopic Polyangiitis. ( 27872779 )
2016
18
Early interstitial lung disease in microscopic polyangiitis: Case report and literature review. ( 27919708 )
2016
19
Corticosteroid-free treatment of tocilizumab monotherapy for microscopic polyangiitis: a single-arm, single-center, clinical trial. ( 26934300 )
2016
20
Paraneoplastic microscopic polyangiitis presenting after thymectomy. ( 27222874 )
2016
21
Microscopic Polyangiitis with Spinal Cord Involvement: A Case Report and Review of the Literature. ( 27068775 )
2016
22
Presence of Citrullinated Histone H3-Positive Neutrophils in Microscopic Polyangiitis from the Early Phase: An Autopsy Proven Case. ( 27427341 )
2016
23
Microscopic polyangiitis complicated with bilateral brachial plexopathy: a case report and review of the literature. ( 26782370 )
2016
24
Pulmonary Microscopic Polyangiitis Presenting as Acute Respiratory Failure from Diffuse Alveolar Hemorrhage. ( 26847106 )
2016
25
Acute cervical myelitis and microscopic polyangiitis. ( 27158038 )
2016
26
Pediatric case of microscopic polyangiitis with skin manifestations resembling vesiculobullous type erythema elevatum diutinum with immunoglobulin A antineutrophil cytoplasmic antibody. ( 27097593 )
2016
27
Long-term outcomes of the WEGENT trial on remission-maintenance for granulomatosis with polyangiitis or microscopic polyangiitis. ( 26473755 )
2015
28
Microscopic polyangiitis associated with pleuropericarditis, pulmonary embolism and pulmonary hemorrhage as a complication of silicosis. ( 26236617 )
2015
29
Microscopic polyangiitis: Advances in diagnostic and therapeutic approaches. ( 25992801 )
2015
30
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema. ( 26236623 )
2015
31
Pleural vasculitides of microscopic polyangiitis with asbestos-related plaques. ( 26740883 )
2015
32
Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort. ( 26297628 )
2015
33
Images in emergency medicine. Woman with cough and dyspnea. Pulmonary-renal syndrome caused by microscopic polyangiitis. ( 25529152 )
2015
34
Effects of cyclophosphamide on the prognosis of Japanese patients with renal vasculitis associated with anti-neutrophil cytoplasmic antibody-positive microscopic polyangiitis. ( 26590052 )
2015
35
Microscopic polyangiitis causing diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. ( 26424944 )
2015
36
Recurrent posterior reversible encephalopathy syndrome in a child with microscopic polyangiitis. ( 25710870 )
2015
37
Intraventricular hemorrhage as a complication of microscopic polyangiitis. ( 26323082 )
2015
38
Different responses to treatment across classified diseases and severities in Japanese patients with microscopic polyangiitis and granulomatosis with polyangiitis: a nationwide prospective inception cohort study. ( 26525413 )
2015
39
Prevalence and responsiveness to treatment of lung abnormalities on chest computed tomography in patients with microscopic polyangiitis - a multicenter, longitudinal, retrospective study of 150 hospital-based consecutive Japanese patients. ( 26474081 )
2015
40
Characteristics and Outcomes of Granulomatosis With Polyangiitis (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy: Results From the European Renal Association-European Dialysis and Transplant Association Registry. ( 25975963 )
2015
41
Reduced survival in microscopic polyangiitis patients with pulmonary fibrosis in a respiratory referral centre. ( 25980836 )
2015
42
Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis. ( 25758890 )
2015
43
Magnetic resonance imaging can reveal fascial vasculitis in a patient with microscopic polyangiitis. ( 26399877 )
2015
44
Antineutrophil cytoplasmic antibody-positive conversion and microscopic polyangiitis development in patients with idiopathic pulmonary fibrosis. ( 25593704 )
2015
45
Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis. ( 26410887 )
2015
46
Clinical features of children with pulmonary microscopic polyangiitis: report of 9 cases. ( 25923706 )
2015
47
Acute Cholecystitis at Initial Presentation of Microscopic Polyangiitis. ( 26007671 )
2015
48
Pulmonary Limited MPO-ANCA Microscopic Polyangiitis and Idiopathic Lung Fibrosis in a Patient with a Diagnosis of IgA Nephropathy. ( 26266064 )
2015
49
Microscopic polyangiitis: A little-known new risk factor of venous thrombosis. ( 26318550 )
2015
50
Anti-neutrophil cytoplasmic antibody-negative microscopic polyangiitis: A case report and literature review. ( 26622387 )
2015

Variations for Microscopic Polyangiitis

Expression for Microscopic Polyangiitis

Search GEO for disease gene expression data for Microscopic Polyangiitis.

Pathways for Microscopic Polyangiitis

Pathways related to Microscopic Polyangiitis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 HLA-B HLA-DRB1 KIR3DL1 KIR3DS1 MPO TNF
2
Show member pathways
12.99 HLA-B HLA-DRB1 KIR3DL1 KIR3DS1
3
Show member pathways
12.35 HLA-B HLA-DRB1 TNF
4
Show member pathways
12.09 HLA-B KIR3DL1 TNF
5 11.99 HLA-B HLA-DRB1 TNF
6
Show member pathways
11.66 HLA-B HLA-DRB1 KIR3DL1 TNF
7 11.51 HLA-B HLA-DRB1 MPO
8 11.45 HLA-DRB1 TNF
9 11.26 HLA-B KIR3DL1 KIR3DS1
10 11.14 MPO TNF
11 10.85 HLA-DRB1 TNF
12 10.46 MPO TNF

GO Terms for Microscopic Polyangiitis

Cellular components related to Microscopic Polyangiitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.46 HLA-B KIR3DL1 KIR3DS1 TNF
2 cell surface GO:0009986 9.43 HLA-B HLA-DRB1 TNF
3 ER to Golgi transport vesicle membrane GO:0012507 8.96 HLA-B HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.62 HLA-B HLA-DRB1

Biological processes related to Microscopic Polyangiitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.26 HLA-B HLA-DRB1
2 antigen processing and presentation GO:0019882 9.16 HLA-B HLA-DRB1
3 immune response GO:0006955 9.02 HLA-B HLA-DRB1 KIR3DL1 KIR3DS1 TNF
4 negative regulation of growth of symbiont in host GO:0044130 8.96 MPO TNF

Molecular functions related to Microscopic Polyangiitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-B HLA-DRB1

Sources for Microscopic Polyangiitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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