MPA
MCID: MCR088
MIFTS: 55

Microscopic Polyangiitis (MPA) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Cardiovascular diseases categories

Summaries for Microscopic Polyangiitis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Microscopic polyangiitis (mpa) is a disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. the kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. mpa is diagnosed in people of all ages, all ethnicities, and both genders. the cause of this disorder is unknown. last updated: 2/4/2009

MalaCards: Microscopic Polyangiitis, also known as microscopic polyarteritis, is related to vasculitis and nephritis, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, acute diarrhea and lung/pulmonary/alveolar hemorrhage/hematoma. An important gene associated with Microscopic Polyangiitis is KIR2DS3 (killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3), and among its related pathways are Fc-GammaR Pathway and Tuberculosis. The compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Wikipedia:66 Microscopic polyangiitis (also known as \"Microscopic polyarteritis,\" \"Microscopic polyarteritis... more...

Aliases & Classifications for Microscopic Polyangiitis

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Sources:
44NIH Rare Diseases, 50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
microscopic polyangiitis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

microscopic polyangiitis 44 50 63
microscopic polyarteritis 50 63
vasculitis, leukocytoclastic, cutaneous 63
hypersensitivity angiitis 50
micropolyangiitis 50
mpa 50


External Ids:

MESH via Orphanet37 D055953
ICD10 via Orphanet27 M31.7
UMLS via Orphanet64 C0343192
SNOMED-CT via Orphanet60 60555002
ICD1026 M31.0, M31.7

Related Diseases for Microscopic Polyangiitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Microscopic Polyangiitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.1MPO, FCGR3B
2nephritis30.4MPO, FCGR3B
3systemic lupus erythematosus30.2FCGR3B
4hypersensitivity vasculitis30.2MPO, FCGR3B
5arthritis30.1FCGR2B, FCGR3B, MPO
6rheumatoid arthritis29.9MPO, FCGR3B, FCGR2B, KIR2DL1
7wegener's granulomatosis10.9
8polyarteritis nodosa10.8
9churg-strauss syndrome10.8
10granulomatosis with polyangiitis10.5
11glomerulonephritis10.5
12pulmonary fibrosis10.5
13neuropathy10.4
14aneurysm10.4
15cerebritis10.4
16hepatitis10.4
17purpura10.4
18breast cancer10.4
19influenza10.3
20peripheral neuropathy10.3
21diffuse alveolar hemorrhage10.3
22graft versus host disease10.2
23primary biliary cirrhosis10.2
24amyloidosis10.2
25endocarditis10.2
26pancreatitis10.2
27bacteremia10.2
28endotheliitis10.2
29allergic cutaneous vasculitis10.1
30cutaneous necrotizing vasculitis10.1
31cardiac tamponade10.1
32autoimmune thyroiditis10.1
33hepatitis c10.1
34relapsing polychondritis10.1
35iga glomerulonephritis10.1
36antiphospholipid syndrome10.1
37hereditary hemorrhagic telangiectasia10.1
38goodpasture syndrome10.1
39miliary tuberculosis10.1
40end stage renal failure10.1
41autoimmune hepatitis10.1
42polymyalgia rheumatica10.1
43subacute bacterial endocarditis10.1
44idiopathic pulmonary fibrosis10.1
45sensorineural hearing loss10.1
46coronary aneurysm10.1
47henoch-schoenlein purpura10.1
48aortic valve insufficiency10.1
49crescentic glomerulonephritis10.1
50aortic aneurysm10.1

Graphical network of the top 20 diseases related to Microscopic Polyangiitis:



Diseases related to microscopic polyangiitis

Symptoms for Microscopic Polyangiitis

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50Orphanet
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Symptoms:

50 (show all 39)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • acute diarrhea
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • vascularitis/vasculitides/arteritis
  • hemoptysis
  • mesenteric/intestinal infarction
  • cutis marmorata/marbled skin/livedo
  • intestinal perforation
  • neuritis/polyneuritis/multineuritis
  • peritonitis/peritoneal abscess
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • epistaxis/nose bleeding
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • peripheral neuropathy
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous rash
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cardiac rhythm disorder/arrhythmia
  • articular/joint pain/arthralgia
  • fever/chilling
  • renal failure
  • arthritis/synovitis/synovial proliferation
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • heart/cardiac failure
  • gangrena/necrosis
  • myalgia/muscular pain
  • retinal vascular anomalies/retinal telangiectasia
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • renal glomerular defect/glomerulopathy
  • purpura/petichiae
  • pancreatitis
  • venous thrombosis/phlebitis/thrombophlebitis
  • hematuria/microhematuria
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • autoimmunity/autoimmune reaction/autoantibodies
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Microscopic Polyangiitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Microscopic Polyangiitis

Drug clinical trials:

Search ClinicalTrials for Microscopic Polyangiitis

Search NIH Clinical Center for Microscopic Polyangiitis

Search CenterWatch for Microscopic Polyangiitis

Genetic Tests for Microscopic Polyangiitis

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Anatomical Context for Microscopic Polyangiitis

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34MalaCards
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MalaCards organs/tissues related to Microscopic Polyangiitis:

34
Skin, Lung, Kidney, Bone, Heart, Liver, Breast, T cells, Bone marrow, B cells, Endothelial, Spinal cord, Prostate, Testes, Colon, Thyroid

Animal Models for Microscopic Polyangiitis or affiliated genes

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Publications for Microscopic Polyangiitis

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Sources:
53PubMed
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Articles related to Microscopic Polyangiitis:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Long-term damage assessment in patients with microscopic polyangiitis and renal-limited vasculitis using the Vasculitis Damage Index. (24261767)
2014
2
Cutaneous miliary tuberculosis in a patient with long-term steroid treatment for microscopic polyangiitis. (23608070)
2013
3
Hypertrophic pachymeningitis in an individual with microscopic polyangiitis. (23772738)
2013
4
Current status of the treatment of microscopic polyangiitis and granulomatosis with polyangiitis in Japan. (22760432)
2013
5
Microscopic Polyangiitis Presenting With Hemorrhagic Stroke. (23690295)
2013
6
Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis. (23690996)
2013
7
Microscopic polyangiitis secondary to silica exposure. (23886979)
2013
8
Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis. (22787316)
2012
9
The contrasting epidemiology of granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis. (22258386)
2012
10
Clinical features and outcome of microscopic polyangiitis under a new consensus algorithm of ANCA-associated vasculitides in Korea. (21898069)
2012
11
Effects of mycophenolate mofetil combined with corticosteroids for induction therapy of microscopic polyangiitis. (21311184)
2011
12
Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis. (21738252)
2011
13
Diffuse Alveolar Hemorrhage in a 39-year-old Woman: Unusual Initial Presentation of Microscopic Polyangiitis. (22324034)
2011
14
A case of SjAPgren syndrome with pulmonary amyloidosis complicating microscopic polyangiitis. (21437616)
2011
15
GI involvement of sigmoid mucosal erosion in a 13-year-old girl with microscopic polyangiitis. (21195409)
2011
16
A case of femoral hemorrhage in a patient with microscopic polyangiitis with low levels of myeloperoxidase-antineutrophil cytoplasmic autoantibody. (21318302)
2011
17
AC13, a C-terminal fragment of apolipoprotein A-I, is a candidate biomarker for microscopic polyangiitis. (21792834)
2011
18
Peripheral neuropathy as a first sign of microscopic polyangiitis. (21183256)
2011
19
Prevalence and outcome of pulmonary fibrosis in microscopic polyangiitis. (19926741)
2010
20
B cell abnormalities in Wegener's granulomatosis and microscopic polyangiitis: role of CD25+-expressing B cells. (20716663)
2010
21
Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients. (20131268)
2010
22
Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial. (20643762)
2010
23
Cutaneous manifestations and histological features of microscopic polyangiitis. (19059827)
2009
24
Hereditary hemorrhagic telangiectasia in a patient with microscopic polyangiitis. (19640374)
2009
25
Expression of CD57 on CD8+ T lymphocytes of patients with Wegener's granulomatosis and microscopic polyangiitis: evidence for continuous activation of CD8+ cells. (19646341)
2009
26
Microscopic polyangiitis: a rare ANCA-associated small-vessel vasculitis. (19032892)
2008
27
Intravenous immunoglobulin in Wegener's granulomatosis and microscopic polyangiitis. (18576349)
2008
28
The occurrence of sensorineural hearing loss in a patient with myeloperoxidase-anti-neutrophil cytoplasmic antibody-related microscopic polyangiitis. (16969635)
2007
29
Peripheral neuropathy in Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. (17299018)
2007
30
Microscopic polyangiitis or Wegener's granulomatosis? That is the question. (16548912)
2006
31
Microscopic polyangiitis histologically confirmed by biopsy from nasal cavity and paranasal sinuses: a case report. (16625340)
2006
32
Takotsubo (ampulla-shaped) cardiomyopathy associated with microscopic polyangiitis. (15805717)
2005
33
Microscopic polyangiitis complicated by the development of prostate cancer and flutamide-induced hepatitis. (16307333)
2005
34
Microscopic polyangiitis presenting with liver dysfunction preceding rapidly progressive necrotizing glomerulonephritis. (15455987)
2004
35
Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate. (14872461)
2004
36
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)
2003
37
Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis. (12743792)
2003
38
Anti-myeloperoxidase antibodies in patients with microscopic polyangiitis. (14646155)
2003
39
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
40
Historical perspective of vasculitis: polyarteritis nodosa and microscopic polyangiitis. (11798985)
2002
41
Peripheral nonulcerative keratitis as a presenting sign of microscopic polyangiitis. (11413410)
2001
42
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
43
Microscopic polyangiitis in a patient with relapsing polychondritis. (11257169)
2001
44
Microscopic polyangiitis (microscopic polyarteritis). (11296991)
2001
45
Limited cutaneous systemic sclerosis associated with MPO-ANCA positive renal small vessel vasculitis of the microscopic polyangiitis type. (10977809)
2000
46
Pachymeningitis in microscopic polyangiitis (MPA): a case report and a review of central nervous system involvement in MPA. (10895382)
2000
47
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. (10464553)
1999
48
Fibrosing alveolitis predating microscopic polyangiitis. (10503564)
1999
49
Microscopic polyangiitis presenting as schizophrenia. (10399798)
1999
50
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmission to the neonate. (9746391)
1998

Variations for Microscopic Polyangiitis

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Expression for genes affiliated with Microscopic Polyangiitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Microscopic Polyangiitis

Search GEO for disease gene expression data for Microscopic Polyangiitis.

Pathways for genes affiliated with Microscopic Polyangiitis

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
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Pathways related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3FCGR2B, FCGR3B
29.3FCGR2B, FCGR3B
39.3FCGR3B, FCGR2B
49.3FCGR3B, FCGR2B
5
Show member pathways
9.2KIR2DL1, KIR2DS3
68.8FCGR2B, FCGR3B, MPO
7
Show member pathways
8.8KIR3DS1, KIR2DL1, KIR2DS3
8
Show member pathways
8.7KIR2DL1, KIR2DS3, FCGR2B
98.7KIR2DL1, KIR2DS3, FCGR2B
10
Show member pathways
Immune response CD16 signaling in NK cells61
8.6FCGR3B, KIR2DS3, KIR2DL1

Compounds for genes affiliated with Microscopic Polyangiitis

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tositumomab52 1210.7FCGR2B, FCGR3B
2ibritumomab52 1210.7FCGR2B, FCGR3B
3alefacept46 1210.7FCGR2B, FCGR3B
4bevacizumab52 1210.7FCGR2B, FCGR3B
5efalizumab46 1210.7FCGR3B, FCGR2B
6daclizumab46 1210.6FCGR2B, FCGR3B
7basiliximab46 1210.6FCGR2B, FCGR3B
8natalizumab46 1210.6FCGR3B, FCGR2B
9alemtuzumab46 1210.6FCGR3B, FCGR2B
10gemtuzumab ozogamicin52 46 1211.6FCGR2B, FCGR3B
11adalimumab46 52 1211.6FCGR3B, FCGR2B
12abciximab46 1210.6FCGR2B, FCGR3B
13cetuximab46 52 1211.6FCGR2B, FCGR3B
14etanercept46 52 1211.5FCGR3B, FCGR2B
15cytochalasin b469.5FCGR3B, MPO
16n-formylmethionyl-leucylphenylalanine469.4MPO, FCGR3B
17trastuzumab46 52 1211.4FCGR2B, FCGR3B
18rituximab46 52 1211.3FCGR2B, FCGR3B
19leukotriene b446 62 2511.2MPO, FCGR3B
20fmlp469.2MPO, FCGR3B, FCGR2B
21prednisolone46 30 1211.0FCGR3B, MPO
22superoxide46 2510.0FCGR2B, FCGR3B, MPO
23lipid468.5KIR2DL1, FCGR2B, FCGR3B

GO Terms for genes affiliated with Microscopic Polyangiitis

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17Gene Ontology
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Cellular components related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8KIR3DS1, KIR2DL1, KIR2DS3

Biological processes related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.1KIR2DL1, FCGR2B
2immune responseGO:0069557.8KIR3DS1, KIR2DL1, FCGR2B, FCGR3B

Molecular functions related to Microscopic Polyangiitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.3FCGR2B, FCGR3B

Products for genes affiliated with Microscopic Polyangiitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Microscopic Polyangiitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet