MCID: MCR112
MIFTS: 30

Microvascular Complications of Diabetes 2

Categories: Genetic diseases, Eye diseases, Neuronal diseases, Nephrological diseases

Aliases & Classifications for Microvascular Complications of Diabetes 2

MalaCards integrated aliases for Microvascular Complications of Diabetes 2:

Name: Microvascular Complications of Diabetes 2 53 71 28 13
Proliferative Diabetic Retinopathy 71 69
Diabetic Nephropathy 71 69
Mvcd2 53 71
Microvascular Complications of Diabetes, Susceptibility to, 2 53
Proliferative Retinopathy, Diabetic, Susceptibility to 53
End-Stage Renal Disease, Diabetic, Susceptibility to 53
Proliferative Retinopathy, Diabetic 53
End-Stage Renal Disease, Diabetic 53
Diabetic End-Stage Renal Disease 71

Classifications:



External Ids:

OMIM 53 612623
MeSH 41 D048909
UMLS 69 C0011881

Summaries for Microvascular Complications of Diabetes 2

UniProtKB/Swiss-Prot : 71 Microvascular complications of diabetes 2: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 2, also known as proliferative diabetic retinopathy, is related to microvascular complications of diabetes 3 and microvascular complications of diabetes 7. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin).

Description from OMIM: 612623

Related Diseases for Microvascular Complications of Diabetes 2

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 11.6
2 microvascular complications of diabetes 7 11.5
3 microvascular complications of diabetes 1 11.4

Symptoms & Phenotypes for Microvascular Complications of Diabetes 2

Clinical features from OMIM:

612623

Drugs & Therapeutics for Microvascular Complications of Diabetes 2

Genetic Tests for Microvascular Complications of Diabetes 2

Genetic tests related to Microvascular Complications of Diabetes 2:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 2 28 EPO

Anatomical Context for Microvascular Complications of Diabetes 2

Publications for Microvascular Complications of Diabetes 2

Articles related to Microvascular Complications of Diabetes 2:

(show top 50) (show all 616)
# Title Authors Year
1
The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. ( 28973045 )
2017
2
MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. ( 28571008 )
2017
3
Serous retinal detachment after panretinal photocoagulation for proliferative diabetic retinopathy: a case report. ( 28923115 )
2017
4
Association of IL-6 Gene (-174 and -572 G/C) Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Population. ( 28651253 )
2017
5
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy. ( 27860331 )
2017
6
Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy. ( 28272234 )
2017
7
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study. ( 28446148 )
2017
8
A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy. ( 28978321 )
2017
9
Association of Complement C5 Gene Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Han Population. ( 26934706 )
2016
10
Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes. ( 26940815 )
2016
11
Association between FNDC5 genetic variants and proliferative diabetic retinopathy in a Chinese population. ( 26926664 )
2016
12
Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma. ( 27010230 )
2016
13
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells. ( 27050952 )
2016
14
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. ( 26039997 )
2015
15
Genetic algorithm based feature selection combined with dual classification for the automated detection of proliferative diabetic retinopathy. ( 25841182 )
2015
16
Social deprivation as a risk factor for late presentation of proliferative diabetic retinopathy. ( 25733801 )
2015
17
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25784784 )
2015
18
High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with proliferative diabetic retinopathy. ( 25822410 )
2015
19
Re: Role of combined cataract surgery and ranibizumab injection in postoperative macula edema in non-proliferative diabetic retinopathy. ( 25635581 )
2015
20
Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). ( 25637870 )
2015
21
The effects of pleiotrophin in proliferative diabetic retinopathy. ( 25617851 )
2015
22
Role of NF-I_B activation and VEGF gene polymorphisms in VEGF up regulation in non-proliferative and proliferative diabetic retinopathy. ( 25956512 )
2015
23
The rs3917779 polymorphism of P-selectin's significant association with proliferative diabetic retinopathy in Yazd, Iran. ( 26344728 )
2015
24
The -308G>a polymorphism of the TNF gene is associated with proliferative diabetic retinopathy in Caucasian Brazilians with type 2 diabetes. ( 25634985 )
2015
25
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25609907 )
2015
26
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. ( 27215012 )
2015
27
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes. ( 26720478 )
2015
28
The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor. ( 24871583 )
2015
29
Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy. ( 25604687 )
2015
30
Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure. ( 25601533 )
2015
31
Elevated LRP6 levels correlate with vascular endothelial growth factor in the vitreous of proliferative diabetic retinopathy. ( 26120271 )
2015
32
Increase of Sialylated N-Glycansin Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy. ( 26177396 )
2015
33
The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. ( 25676319 )
2015
34
Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema. ( 25631486 )
2015
35
Painless Indirect Argon Laser in High Risk Proliferative Diabetic Retinopathy. ( 25902110 )
2015
36
Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy. ( 25686060 )
2015
37
Programmed Death 1 (PD-1) is involved in the development of proliferative diabetic retinopathy by mediating activation-induced apoptosis. ( 26321864 )
2015
38
Expression of intraocular peroxisome proliferator-activated receptor gamma in patients with proliferative diabetic retinopathy. ( 25468312 )
2015
39
Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy. ( 25899460 )
2015
40
CHRONIC MYELOID LEUKEMIA DIAGNOSED IN A PATIENT WITH UNCONTROLLED PROLIFERATIVE DIABETIC RETINOPATHY. ( 25719936 )
2015
41
Identification of chemokines and growth factors in proliferative diabetic retinopathy vitreous. ( 25401103 )
2014
42
Fourier-domain optical coherence tomography evaluation of retinal and optic nerve head neovascularisation in proliferative diabetic retinopathy. ( 24158844 )
2014
43
Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. ( 25558661 )
2014
44
Macular tractional retinoschisis in proliferative diabetic retinopathy: clinical characteristics and surgical outcome. ( 24107645 )
2014
45
Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy. ( 25349789 )
2014
46
Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. ( 25329921 )
2014
47
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. ( 25310689 )
2014
48
Computer aided quantification for retinal lesions in patients with moderate and severe non-proliferative diabetic retinopathy: a retrospective cohort study. ( 25359611 )
2014
49
Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients. ( 24854763 )
2014
50
Effect of intravitreal bevacizumab on serum, aqueous, and vitreous humor levels of erythropoietin in patients with proliferative diabetic retinopathy. ( 25371057 )
2014

Variations for Microvascular Complications of Diabetes 2

ClinVar genetic disease variations for Microvascular Complications of Diabetes 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 EPO NM_000799.3(EPO): c.-1306C> A single nucleotide variant risk factor rs1617640 GRCh37 Chromosome 7, 100317298: 100317298

Expression for Microvascular Complications of Diabetes 2

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 2.

Pathways for Microvascular Complications of Diabetes 2

GO Terms for Microvascular Complications of Diabetes 2

Sources for Microvascular Complications of Diabetes 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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