MCID: MCR113
MIFTS: 44

Microvascular Complications of Diabetes 3

Categories: Genetic diseases, Nephrological diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 3

MalaCards integrated aliases for Microvascular Complications of Diabetes 3:

Name: Microvascular Complications of Diabetes 3 54 71 29 13 38
Diabetic Nephropathy 38 71 69
Diabetic End-Stage Renal Disease 71
Diabetic Nephropathies 52
Mvcd3 71

Classifications:



External Ids:

OMIM 54 612624
MeSH 42 D048909

Summaries for Microvascular Complications of Diabetes 3

UniProtKB/Swiss-Prot : 71 Microvascular complications of diabetes 3: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 3, also known as diabetic nephropathy, is related to peripheral artery disease and microvascular complications of diabetes 4. An important gene associated with Microvascular Complications of Diabetes 3 is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Peptide hormone metabolism. The drugs Insulin Glargine and Insulin Lispro have been mentioned in the context of this disorder. Affiliated tissues include Kidney, bone and kidney, and related phenotypes are behavior/neurological and cardiovascular system

Description from OMIM: 612624

Related Diseases for Microvascular Complications of Diabetes 3

Diseases in the Microvascular Complications of Diabetes 1 family:

Microvascular Complications of Diabetes 4 Microvascular Complications of Diabetes 7
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 5 Microvascular Complications of Diabetes 3

Diseases related to Microvascular Complications of Diabetes 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
id Related Disease Score Top Affiliating Genes
1 peripheral artery disease 28.8 ACE AGT AGTR1 ALB INS
2 microvascular complications of diabetes 4 11.4
3 microvascular complications of diabetes 7 11.4
4 microvascular complications of diabetes 1 11.4
5 microvascular complications of diabetes 6 11.4
6 microvascular complications of diabetes 2 11.4
7 microvascular complications of diabetes 5 11.4
8 diabetic angiopathy 10.8
9 pelizaeus-merzbacher-like disease 10.7 ACE AGT
10 non-congenital cyst of kidney 10.7 ACE ALB
11 synovial chondromatosis 10.6 ACE ALB
12 cataract 10.6 ALB INS
13 clitoris cancer 10.6 ACE AGTR1
14 submucous uterine fibroid 10.5 ALB INS
15 familial isolated pituitary adenoma 10.5 AGT AGTR1
16 myopia 10.5 ACE ALB
17 idiopathic juxtafoveal retinal telangiectasia 10.5 ACE INS
18 tonsil cancer 10.5 ALB INS
19 mental retardation cataracts calcified pinnae myopathy 10.5 AGT AGTR1
20 conjunctival vascular disease 10.5 ALB INS
21 hemopericardium 10.5 ALB INS
22 cystinosis 10.4 ACE AGT ALB
23 cervix uteri carcinoma in situ 10.4 ACE AGT ALB
24 aortopulmonary window 10.4 ACE AGT AGTR1
25 chylocele of tunica vaginalis 10.4 ACE AGT AGTR1
26 cascade stomach 10.3 ACE AGT AGTR1
27 hypertrichosis 10.3 ACE ALB INS
28 microcephaly 8, primary, autosomal recessive 10.3 ALB NPHS1
29 renal tubular dysgenesis 10.3 ACE AGT AGTR1
30 survival motor neuron spinal muscular atrophy 10.3 ACE ALB INS
31 laryngostenosis 10.3 ACE AGT AGTR1
32 nasopharyngeal carcinoma 2 10.3 ACE ALB NPHS1
33 joint disorders 10.3 ACE AGT AGTR1
34 broad ligament malignant neoplasm 10.3 ACE AGTR1 ALB
35 congenital bilateral megacalycosis 10.3 ACE AGT AGTR1
36 rumination disorder 10.3 AKR1B1 INS
37 endotheliitis 10.3
38 lymphadenitis 10.3 ACE AGTR1
39 12q15q21.1 microdeletion syndrome 10.3 ACE TGFB1
40 astrocytoma 10.3 ALB NAGLU
41 pleural tuberculosis 10.2 AGT AGTR1 ALB
42 malignant type ab thymoma 10.2 ACE AGTR1 INS
43 acrofrontofacionasal dysostosis 10.2 ACE AGT AGTR1
44 sarcocystosis 10.2 ALB CTGF NPHS1
45 diffuse large b-cell lymphoma 10.1 ACE AKR1B1 INS
46 retinitis pigmentosa 70 10.1 ACE ALB NAGLU
47 fissured tongue 10.1 AKR1B1 ALB INS
48 hyperlipoproteinemia type iv 10.1 ALB INS
49 choroiditis 10.1 ACE ALB NAGLU
50 idiopathic juvenile osteoporosis 10.1 ALB NAGLU

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 3:



Diseases related to Microvascular Complications of Diabetes 3

Symptoms & Phenotypes for Microvascular Complications of Diabetes 3

Clinical features from OMIM:

612624

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 3:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 AGTR1 AKR1B1 INS NAGLU TGFB1 ACE
2 cardiovascular system MP:0005385 9.97 ACE AGER AGT AGTR1 CTGF INS
3 growth/size/body region MP:0005378 9.97 AGER AGT AGTR1 AKR1B1 CTGF INS
4 homeostasis/metabolism MP:0005376 9.96 AGER AGT AGTR1 AKR1B1 ALB CTGF
5 adipose tissue MP:0005375 9.83 ACE AGT AGTR1 INS TGFB1
6 mortality/aging MP:0010768 9.65 ACE AGT AGTR1 AKR1B1 ALB CTGF
7 liver/biliary system MP:0005370 9.63 ACE AGT ALB INS NAGLU TGFB1
8 renal/urinary system MP:0005367 9.32 ACE AGER AGT AGTR1 AKR1B1 ALB

Drugs & Therapeutics for Microvascular Complications of Diabetes 3

Drugs for Microvascular Complications of Diabetes 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Glargine Approved Phase 4 160337-95-1
2
Insulin Lispro Approved Phase 4 133107-64-9
3
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
4 Hypoglycemic Agents Phase 4,Phase 3
5 insulin Phase 4,Phase 3,Phase 2
6 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2
7 Insulin, Isophane Phase 4
8 Isophane insulin, beef Phase 4
9 Isophane Insulin, Human Phase 4
10 Anticholesteremic Agents Phase 4
11 Antimetabolites Phase 4
12 Cholestyramine Resin Phase 4
13 Hypolipidemic Agents Phase 4
14 Lipid Regulating Agents Phase 4
15
Metformin Approved Phase 3 657-24-9 14219 4091
16
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
17
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
18
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
19
Glimepiride Approved Phase 3 93479-97-1 3476
20 tannic acid Approved, Nutraceutical Phase 3
21
Ruboxistaurin Investigational Phase 3 202260-21-7, 169939-94-0 153999
22 Anti-Arrhythmia Agents Phase 3
23 Immunosuppressive Agents Phase 3
24 Incretins Phase 2, Phase 3
25 Antirheumatic Agents Phase 3
26 Analgesics Phase 3
27 Analgesics, Non-Narcotic Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30 Antipyretics Phase 3
31 Cyclooxygenase Inhibitors Phase 3
32 Fibrinolytic Agents Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35
Fenofibrate Approved 49562-28-9 3339
36
Gemfibrozil Approved 25812-30-0 3463
37
Insulin Aspart Approved 116094-23-6 16132418
38
Insulin Detemir Approved 169148-63-4 5311023
39
Linagliptin Approved 668270-12-0 10096344
40
Liraglutide Approved 204656-20-2 44147092
41
Pioglitazone Approved, Investigational 111025-46-8 4829
42
Repaglinide Approved, Investigational 135062-02-1 65981
43
Saxagliptin Approved 361442-04-8 11243969
44
Gliclazide Approved 21187-98-4 3475
45
Colchicine Approved 64-86-8 6167 2833
46
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
47
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
48
Angiotensin II Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
49 Bone Density Conservation Agents
50 Ergocalciferols

Interventional clinical trials:

(show all 26)

id Name Status NCT ID Phase Drugs
1 Glargine Versus NPH in Patients With Chronic Kidney Disease Completed NCT02451917 Phase 4 Glargine;NPH insulin
2 Making Ramadhan Fasting a Safer Experience With Technology Study Completed NCT02189135 Phase 4
3 PRELIMINARY EVALUATION OF PHARMACOLOGICAL LOWERING OF AGEs Recruiting NCT02249897 Phase 4 CHOLESTYRAMINE
4 Diabetes Prevention Program Outcomes Study Unknown status NCT00038727 Phase 3 Metformin
5 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
6 The Microvascular Complications Study Completed NCT00222508 Phase 3
7 Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Completed NCT00081328 Phase 3 Metformin;Rosiglitazone
8 OatMeal and Insulin Resistance: OMA-IR Completed NCT00401453 Phase 3
9 Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) Completed NCT00032487 Phase 3 Insulin;Glimepiride;Rosiglitazone;Metformin
10 Renal and Peripheral Hemodynamic Function in Patients With Type 1 Diabetes Mellitus Completed NCT00297401 Phase 3 ruboxistaurin;placebo
11 The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial Completed NCT00375388 Phase 3 Metformin on top of intensive insulin therapy
12 The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity. Recruiting NCT02036138 Phase 2, Phase 3 Advanced Medical Therapy
13 Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes Not yet recruiting NCT02895113 Phase 3 Aspirin
14 A Comprehensive Longitudinal Cohort Study in Type 2 Diabetes With High Risk of Cardiovascular Diseases in China Unknown status NCT01307410
15 Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients Unknown status NCT02245633
16 Prevention and Treatment Of Diabetes Complications With Gastric Surgery or Intensive Medicines Unknown status NCT01974544 Best medical treatment;General interventions for all groups: blood presure;General interventions for all groups: dysilipidemia
17 The Effects of Glycemic Optimization Before Gastric Bypass Surgery Completed NCT01353118
18 Quality of Life and Treatment Satisfaction of People With Type 2 Diabetes: A European Survey Completed NCT00916513
19 Intraperitoneal vs Subcutaneous Insulin Administration in Type 1 Diabetes Mellitus Completed NCT01621308
20 Nephrologic Prognosis 10 Years After Diabetes Cell Therapy Recruiting NCT02627690
21 HbA1c Variability in Type II Diabetes Recruiting NCT02879409 Metformin;Gliclazide;Sitagliptin;Liraglutide;Pioglitazone;Dapagliflozin;human insulin
22 Prevention of Microvascular Complications in Prediabetes e-PREDICE Study Recruiting NCT03222765 Placebo, metformin, linagliptin, linagliptin + metformin
23 Swiss Diabetes Registry - SwissDiab Study Recruiting NCT01179815
24 Low-dose Colchicine in Patients With Type 2 Diabetes Mellitus and Microalbuminuria Active, not recruiting NCT02035891 colchicine 0.5mg/d;placebo 0.5mg/d
25 DISCOVERing Treatment Reality of Type 2 Diabetes in Real World Setting in Japan Active, not recruiting NCT02226822
26 Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine Withdrawn NCT02011178

Search NIH Clinical Center for Microvascular Complications of Diabetes 3

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 3:
Mesenchymal precursor cells for type 2 diabetes
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 3:
Mesenchymal Precursor Cells (STRO-3 selected)

Genetic Tests for Microvascular Complications of Diabetes 3

Genetic tests related to Microvascular Complications of Diabetes 3:

id Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 3 29

Anatomical Context for Microvascular Complications of Diabetes 3

MalaCards organs/tissues related to Microvascular Complications of Diabetes 3:

39
Bone, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 3:
id Tissue Anatomical CompartmentCell Relevance
1 Kidney Podocyte Layer Podocytes Potential therapeutic candidate, affected by disease

Publications for Microvascular Complications of Diabetes 3

Variations for Microvascular Complications of Diabetes 3

ClinVar genetic disease variations for Microvascular Complications of Diabetes 3:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893

Expression for Microvascular Complications of Diabetes 3

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 3.

Pathways for Microvascular Complications of Diabetes 3

GO Terms for Microvascular Complications of Diabetes 3

Cellular components related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ACE AGT AKR1B1 ALB CTGF INS
2 blood microparticle GO:0072562 9.33 AGT ALB TGFB1
3 extracellular region GO:0005576 9.23 ACE AGER AGT ALB CNDP1 CTGF

Biological processes related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 AGT CTGF INS TGFB1
2 aging GO:0007568 9.8 AGT CTGF TGFB1
3 kidney development GO:0001822 9.76 ACE AGT AGTR1
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 AGT INS TGFB1
5 regulation of cell growth GO:0001558 9.7 AGT AGTR1 CTGF
6 response to wounding GO:0009611 9.69 AGER CTGF TGFB1
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 AGER AGT INS TGFB1
8 negative regulation of gene expression GO:0010629 9.65 CTGF TGFB1
9 positive regulation of protein tyrosine kinase activity GO:0061098 9.65 ACE AGT
10 blood vessel remodeling GO:0001974 9.64 ACE AGT
11 positive regulation of reactive oxygen species metabolic process GO:2000379 9.64 AGT AGTR1
12 positive regulation of protein localization to nucleus GO:1900182 9.62 INS TGFB1
13 positive regulation of collagen biosynthetic process GO:0032967 9.62 CTGF TGFB1
14 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 AGT TGFB1
15 tissue homeostasis GO:0001894 9.61 AKR1B1 CTGF
16 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.6 AGT AGTR1
17 regulation of blood vessel diameter GO:0097746 9.59 ACE AGTR1
18 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
19 angiotensin maturation GO:0002003 9.57 ACE AGT
20 positive regulation of superoxide anion generation GO:0032930 9.56 AGT TGFB1
21 positive regulation of cholesterol esterification GO:0010873 9.54 AGT AGTR1
22 regulation of DNA binding GO:0051101 9.49 AGER TGFB1
23 positive regulation of NAD(P)H oxidase activity GO:0033864 9.48 AGT AGTR1
24 renin-angiotensin regulation of aldosterone production GO:0002018 9.46 AGT AGTR1
25 regulation of renal sodium excretion GO:0035813 9.43 AGT AGTR1
26 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.4 AGT AGTR1
27 regulation of vasoconstriction GO:0019229 9.33 ACE AGT AGTR1
28 mononuclear cell proliferation GO:0032943 9.32 ACE TGFB1
29 regulation of renal output by angiotensin GO:0002019 9.26 ACE AGT
30 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
31 positive regulation of cellular protein metabolic process GO:0032270 8.92 AGT AGTR1 INS TGFB1

Molecular functions related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 AGT CTGF TGFB1
2 carboxypeptidase activity GO:0004180 8.96 ACE CNDP1
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Microvascular Complications of Diabetes 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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