MCID: MCR113
MIFTS: 55

Microvascular Complications of Diabetes 3

Categories: Genetic diseases, Eye diseases, Neuronal diseases, Nephrological diseases

Aliases & Classifications for Microvascular Complications of Diabetes 3

MalaCards integrated aliases for Microvascular Complications of Diabetes 3:

Name: Microvascular Complications of Diabetes 3 53 71 28 13 37
Diabetic Nephropathy 37 72 71 36 69
Mvcd3 53 71
Microvascular Complications of Diabetes, Susceptibility to, 3 53
End-Stage Renal Disease, Diabetic, Susceptibility to 53
Nephropathy, Diabetic, Susceptibility to 53
End-Stage Renal Disease, Diabetic 53
Diabetic End-Stage Renal Disease 71
Diabetic Nephropathies 51
Nephropathy, Diabetic 53

Classifications:



External Ids:

OMIM 53 612624
MeSH 41 D048909
KEGG 36 H01456
UMLS 69 C0011881

Summaries for Microvascular Complications of Diabetes 3

UniProtKB/Swiss-Prot : 71 Microvascular complications of diabetes 3: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 3, also known as diabetic nephropathy, is related to microvascular complications of diabetes 5 and diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 3 is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Renin-angiotensin system. Affiliated tissues include Kidney and kidney, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function... more...

Description from OMIM: 612624

Related Diseases for Microvascular Complications of Diabetes 3

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.4 ACE AGER AGTR1 AKR1B1 ALB INS
2 diabetes mellitus 29.1 ACE AGT AKR1B1 ALB INS
3 atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease 12.0
4 microvascular complications of diabetes 6 11.5
5 microvascular complications of diabetes 7 11.5
6 microvascular complications of diabetes 4 11.5
7 microvascular complications of diabetes 1 11.0
8 microvascular complications of diabetes 2 11.0
9 feigenbaum bergeron richardson syndrome 11.0
10 pediatric hypertension 10.5 ACE AGT
11 orthostatic proteinuria 10.4 ACE ALB
12 syndrome of inappropriate antidiuretic hormone 10.4 ACE ALB
13 burns 10.4 ALB INS
14 renal artery disease 10.4 ACE AGTR1
15 background diabetic retinopathy 10.4 ALB INS
16 hepatorenal syndrome 10.3 ACE ALB
17 idiopathic edema 10.3 ACE INS
18 meningococcal infection 10.3 AGT AGTR1
19 fascioliasis 10.3 ALB INS
20 fetal erythroblastosis 10.3 ALB INS
21 autonomic nervous system disease 10.3 ALB INS
22 interstitial nephritis 10.3 ACE AGT ALB
23 autosomal dominant polycystic kidney disease 10.2 ACE AGT ALB
24 aortic coarctation 10.2 ACE AGT AGTR1
25 malignant hypertension 10.2 ACE AGT AGTR1
26 oligohydramnios 10.2 ACE AGT AGTR1
27 glucose metabolism disease 10.2 ACE ALB INS
28 renal tubular dysgenesis 10.2 ACE AGT AGTR1
29 acquired metabolic disease 10.2 ACE ALB INS
30 analbuminemia 10.2 ALB NPHS1
31 prediabetes syndrome 10.2 ALB INS
32 membranous nephropathy 10.2 ACE ALB NPHS1
33 ischemic optic neuropathy 10.2 ACE AGT AGTR1
34 hypertensive heart disease 10.2 ACE AGT AGTR1
35 diabetic autonomic neuropathy 10.2 AKR1B1 INS
36 renal hypertension 10.2 ACE AGTR1 ALB
37 renal dysplasia 10.2 ACE AGT AGTR1
38 cerebrovascular disease 10.1 ACE AGTR1 INS
39 coronary artery anomaly 10.1 ACE AGTR1 INS
40 atrial fibrillation 10.1 ACE AGT AGTR1
41 kidney hypertrophy 10.1 ALB CTGF NPHS1
42 familial vesicoureteral reflux 10.1 ACE TGFB1
43 diabetic neuropathy 10.1 ACE AKR1B1 INS
44 acute kidney tubular necrosis 10.0 ALB NAGLU
45 autonomic neuropathy 10.0 AKR1B1 ALB INS
46 pyelonephritis 10.0 ACE ALB NAGLU
47 hyperglycemia 10.0 AKR1B1 ALB INS
48 anuria 10.0 ACE AGT AGTR1 ALB
49 diabetic polyneuropathy 10.0 AGER AKR1B1
50 ascending cholangitis 10.0 ALB TGFB1

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 3:



Diseases related to Microvascular Complications of Diabetes 3

Symptoms & Phenotypes for Microvascular Complications of Diabetes 3

Clinical features from OMIM:

612624

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 3:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 AKR1B1 INS NAGLU TGFB1 AGT AGTR1
2 cardiovascular system MP:0005385 9.97 ACE AGER AGT AGTR1 CTGF INS
3 growth/size/body region MP:0005378 9.97 ACE AGER AGT AGTR1 AKR1B1 CTGF
4 homeostasis/metabolism MP:0005376 9.96 ACE AGER AGT AGTR1 AKR1B1 ALB
5 adipose tissue MP:0005375 9.83 ACE AGT AGTR1 INS TGFB1
6 liver/biliary system MP:0005370 9.7 ACE AGT ALB CTGF INS NAGLU
7 mortality/aging MP:0010768 9.65 AKR1B1 ALB CTGF INS NAGLU NPHS1
8 renal/urinary system MP:0005367 9.32 AGER AGT AGTR1 AKR1B1 ALB INS

Drugs & Therapeutics for Microvascular Complications of Diabetes 3

Search Clinical Trials , NIH Clinical Center for Microvascular Complications of Diabetes 3

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 3:
Mesenchymal precursor cells for type 2 diabetes
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 3:
Mesenchymal Precursor Cells (STRO-3 selected)

Genetic Tests for Microvascular Complications of Diabetes 3

Genetic tests related to Microvascular Complications of Diabetes 3:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 3 28 ACE

Anatomical Context for Microvascular Complications of Diabetes 3

MalaCards organs/tissues related to Microvascular Complications of Diabetes 3:

38
Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 3:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Podocyte Layer Podocytes Potential therapeutic candidate, affected by disease

Publications for Microvascular Complications of Diabetes 3

Articles related to Microvascular Complications of Diabetes 3:

(show top 50) (show all 1463)
# Title Authors Year
1
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). ( 29372470 )
2018
2
Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis. ( 28851298 )
2017
3
MicroRNA-27a promotes podocyte injury via PPARI^-mediated I^-catenin activation in diabetic nephropathy. ( 28277542 )
2017
4
Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy. ( 28748894 )
2017
5
Association of irisin and FNDC5 rs16835198 G>T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study. ( 28479383 )
2017
6
NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy. ( 28137583 )
2017
7
Clinical Implication of Cystatin C and I^2-Microglobulin in Early Detection of Diabetic Nephropathy. ( 28182344 )
2017
8
Cardiac troponin T elevation at dialysis initiation is associated with all-cause and cardiovascular mortality on dialysis in patients without diabetic nephropathy. ( 27178276 )
2017
9
Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes - preliminary results of a family-based study. ( 28255976 )
2017
10
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. ( 28934365 )
2017
11
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. ( 28767064 )
2017
12
Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy. ( 28668213 )
2017
13
Urinary heme oxygenase-1 as a potential biomarker for early diabetic nephropathy. ( 26733347 )
2017
14
Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy. ( 27881486 )
2017
15
Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. ( 28246612 )
2017
16
ApoM/HDL-C and apoM/apoA-I ratios are indicators of diabetic nephropathy in healthy controls and type 2 diabetes mellitus. ( 28073663 )
2017
17
Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy. ( 28356293 )
2017
18
Paraoxonase 1 polymorphisms (L55M and Q192R) as a genetic marker of diabetic nephropathy in youth with type 1 diabetes. ( 26884296 )
2017
19
Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. ( 28289043 )
2017
20
High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy. ( 27003829 )
2017
21
Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. ( 28326331 )
2017
22
The Impact of Peroxisome Proliferator-Activated Receptor Gamma and Its Interaction with Abdominal Obesity on Diabetic Nephropathy in Chinese Han. ( 28013303 )
2017
23
Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy. ( 28119515 )
2017
24
Serum and Plasma Levels of Vascular Endothelial Growth Factors in Relation to Quality of Glucose Control, Biomarkers of Inflammation, and Diabetic Nephropathy. ( 27388431 )
2016
25
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
26
Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy. ( 26646104 )
2016
27
Association between PAI-1 4G/5G polymorphism and diabetic nephropathy: a meta-analysis in the Chinese population. ( 27272255 )
2016
28
The decreased expression of electron transfer flavoprotein I^ is associated with tubular cell apoptosis in diabetic nephropathy. ( 27035869 )
2016
29
Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population. ( 27173343 )
2016
30
Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta-analysis and review. ( 26072975 )
2016
31
Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway. ( 27858840 )
2016
32
The effects of dual and triple combinations of trandolapril, telmisartan, and verapamil on overt proteinuria in the patients with diabetic nephropathy. ( 27215243 )
2016
33
Smoking-associated nodular glomerulosclerosis, a rare renal pathology resembling diabetic nephropathy: case report. ( 28002533 )
2016
34
Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes. ( 27083286 )
2016
35
Genetic association of NAD(P)H quinone oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy. ( 27078674 )
2016
36
Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia. ( 27135947 )
2016
37
Apolipoprotein E genotyping in Egyptian diabetic nephropathy patients. ( 26662731 )
2016
38
miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy. ( 26942205 )
2016
39
Effects of Bone Marrow Mesenchymal Stem Cells on Plasminogen Activator Inhibitor-1 and Renal Fibrosis in Rats with Diabetic Nephropathy. ( 27018336 )
2016
40
Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis. ( 27009287 )
2016
41
Mannose-Binding Lectin and Diabetic Nephropathy in Type 1 Diabetes. ( 26212019 )
2016
42
Ursodeoxycholic acid ameliorated diabetic nephropathy by attenuating hyperglycemia-mediated oxidative stress. ( 27193377 )
2016
43
The correlation of inflammatory markers and plasma vaspin levels in patients with diabetic nephropathy. ( 27216464 )
2016
44
Association of plasminogen activator inhibitor-1 gene polymorphism and type 2 diabetic nephropathy. ( 26616527 )
2016
45
Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study. ( 26821795 )
2016
46
PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus. ( 28116228 )
2016
47
An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. ( 27686049 )
2016
48
The emerging role of fibroblast growth factor 21 in diabetic nephropathy. ( 26915669 )
2016
49
Differential microRNA Profiles Predict Diabetic Nephropathy Progression in Taiwan. ( 27279796 )
2016
50
Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy. ( 27706238 )
2016

Variations for Microvascular Complications of Diabetes 3

ClinVar genetic disease variations for Microvascular Complications of Diabetes 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893

Expression for Microvascular Complications of Diabetes 3

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 3.

Pathways for Microvascular Complications of Diabetes 3

Pathways related to Microvascular Complications of Diabetes 3 according to KEGG:

36
# Name Kegg Source Accession
1 AGE-RAGE signaling pathway in diabetic complications hsa04933
2 Renin-angiotensin system hsa04614
3 FoxO signaling pathway hsa04068
4 Longevity regulating pathway hsa04211

GO Terms for Microvascular Complications of Diabetes 3

Cellular components related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ACE AGT AKR1B1 ALB CTGF INS
2 blood microparticle GO:0072562 9.33 AGT ALB TGFB1
3 extracellular region GO:0005576 9.23 ACE AGER AGT ALB CNDP1 CTGF

Biological processes related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 AGT CTGF INS TGFB1
2 regulation of receptor activity GO:0010469 9.92 AGT CTGF INS TGFB1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.84 AGER CTGF TGFB1
4 aging GO:0007568 9.82 AGT CTGF TGFB1
5 positive regulation of protein phosphorylation GO:0001934 9.8 AGER CTGF TGFB1
6 kidney development GO:0001822 9.75 ACE AGT AGTR1
7 response to estradiol GO:0032355 9.73 AGT CTGF TGFB1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 AGT INS TGFB1
9 regulation of cell growth GO:0001558 9.7 AGT AGTR1 CTGF
10 response to wounding GO:0009611 9.69 AGER CTGF TGFB1
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 AGER AGT INS TGFB1
12 positive regulation of protein tyrosine kinase activity GO:0061098 9.66 ACE AGT
13 blood vessel remodeling GO:0001974 9.66 ACE AGT
14 positive regulation of reactive oxygen species metabolic process GO:2000379 9.65 AGT AGTR1
15 positive regulation of protein localization to nucleus GO:1900182 9.64 INS TGFB1
16 positive regulation of blood vessel diameter GO:0097755 9.64 AGT INS
17 positive regulation of collagen biosynthetic process GO:0032967 9.63 CTGF TGFB1
18 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.62 AGT TGFB1
19 tissue homeostasis GO:0001894 9.61 AKR1B1 CTGF
20 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.61 AGT AGTR1
21 regulation of blood vessel diameter GO:0097746 9.6 ACE AGTR1
22 positive regulation of superoxide anion generation GO:0032930 9.59 AGT TGFB1
23 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
24 angiotensin maturation GO:0002003 9.57 ACE AGT
25 positive regulation of cholesterol esterification GO:0010873 9.54 AGT AGTR1
26 regulation of DNA binding GO:0051101 9.49 AGER TGFB1
27 positive regulation of NAD(P)H oxidase activity GO:0033864 9.48 AGT AGTR1
28 renin-angiotensin regulation of aldosterone production GO:0002018 9.46 AGT AGTR1
29 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.43 AGT AGTR1
30 regulation of renal sodium excretion GO:0035813 9.4 AGT AGTR1
31 regulation of vasoconstriction GO:0019229 9.33 ACE AGT AGTR1
32 regulation of renal output by angiotensin GO:0002019 9.32 ACE AGT
33 mononuclear cell proliferation GO:0032943 9.26 ACE TGFB1
34 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
35 positive regulation of cellular protein metabolic process GO:0032270 8.92 AGT AGTR1 INS TGFB1

Molecular functions related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 AGT CTGF TGFB1
2 carboxypeptidase activity GO:0004180 8.96 ACE CNDP1
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Microvascular Complications of Diabetes 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....