MCID: MCR115
MIFTS: 27

Microvascular Complications of Diabetes 5 malady

Genetic diseases (common), Eye diseases, Nephrological diseases categories

Summaries for Microvascular Complications of Diabetes 5

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MalaCards based summary: Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to retinitis and endotheliitis. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (paraoxonase 1). Affiliated tissues include bone and eye.

Description from OMIM:45 612633

Aliases & Classifications for Microvascular Complications of Diabetes 5

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Microvascular Complications of Diabetes 5, Aliases & Descriptions:

Name: Microvascular Complications of Diabetes 5 45 10 30
Diabetic Retinopathy 30 9 11 43 22 60
 
Retinal Abnormality - Diabetes-Related 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Eye diseases, Nephrological diseases


External Ids:

OMIM45 612633
Disease Ontology9 DOID:8947
ICD9CM27 362.0
NCIt38 C34538
MeSH33 D003930
ICD1025 H36.0

Related Diseases for Microvascular Complications of Diabetes 5

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Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 4 Microvascular Complications of Diabetes 7
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 6
Microvascular Complications of Diabetes 2 Microvascular Complications of Diabetes 3

Diseases related to Microvascular Complications of Diabetes 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis11.1
2endotheliitis11.1
3diabetic macular edema10.7
4retinal detachment10.7
5background diabetic retinopathy10.6
6cataract10.6
7neovascular glaucoma10.6
8severe nonproliferative diabetic retinopathy10.5
9blindness10.5
10neuropathy10.5
11neuronitis10.5
12vitreous detachment10.4
13insulin-like growth factor i10.4
14ischemia10.4
15leukostasis10.4
16choroiditis10.4
17artery disease10.4
18hyperglycemia10.4
19microvascular complications of diabetes 110.3
20atherosclerosis10.3
21macular holes10.3
22retinal microaneurysm10.3
23retinal disease10.3
24hypoxia10.3
25proteinuria10.3
26obesity10.3
27coronary artery disease10.3
28leukemia10.3
29retinal ischemia10.3
30retinal vein occlusion10.3
31rubeosis iridis10.3
32eye disease10.3
33myopia10.3
34eales disease10.3
35myocardial infarction10.2
36retinoschisis10.2
37ischemic heart disease10.2
38acromegaly10.2
39autonomic neuropathy10.2
40open-angle glaucoma10.2
41senile cataract10.2
42sleep disorder10.2
43telangiectasis10.2
44uveitis10.2
45autonomic dysfunction10.2
46vitreoretinopathy, neovascular inflammatory10.0
47prader-willi syndrome10.0
48wolfram syndrome10.0
49hemochromatosis10.0
50celiac disease10.0

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 5:



Diseases related to microvascular complications of diabetes 5

Symptoms for Microvascular Complications of Diabetes 5

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Clinical features from OMIM:

612633

Drugs & Therapeutics for Microvascular Complications of Diabetes 5

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Drug clinical trials:

Search ClinicalTrials for Microvascular Complications of Diabetes 5

Search NIH Clinical Center for Microvascular Complications of Diabetes 5

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 5:
Bone marrow-derived hematopoietic stem cells for retinopathy
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 5:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454
Bone marrow-derived mononuclear cells (family), PMIDs: 23049424, 21225138, 19347139, 23000646

Genetic Tests for Microvascular Complications of Diabetes 5

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Genetic tests related to Microvascular Complications of Diabetes 5:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy22

Anatomical Context for Microvascular Complications of Diabetes 5

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MalaCards organs/tissues related to Microvascular Complications of Diabetes 5:

31
Bone, Eye

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 5:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Microvascular Complications of Diabetes 5 or affiliated genes

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Publications for Microvascular Complications of Diabetes 5

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Variations for Microvascular Complications of Diabetes 5

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Clinvar genetic disease variations for Microvascular Complications of Diabetes 5:

6
id Gene Variation Type Significance SNP ID Assembly Location
1PON1NM_000446.5(PON1): c.163T> A (p.Leu55Met)single nucleotide variantPathogenic, risk factorrs854560GRCh37Chr 7, 94946084: 94946084

Expression for genes affiliated with Microvascular Complications of Diabetes 5

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Search GEO for disease gene expression data for Microvascular Complications of Diabetes 5.

Pathways for genes affiliated with Microvascular Complications of Diabetes 5

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Compounds for genes affiliated with Microvascular Complications of Diabetes 5

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GO Terms for genes affiliated with Microvascular Complications of Diabetes 5

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Products for genes affiliated with Microvascular Complications of Diabetes 5

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Microvascular Complications of Diabetes 5

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet