MCID: MDD003
MIFTS: 36

Middle Cerebral Artery Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Middle Cerebral Artery Infarction

MalaCards integrated aliases for Middle Cerebral Artery Infarction:

Name: Middle Cerebral Artery Infarction 37 12 14
Infarction, Middle Cerebral Artery 41 69
Infarction Middle Cerebral Artery 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3525
MeSH 41 D020244
UMLS 69 C0740392

Summaries for Middle Cerebral Artery Infarction

MalaCards based summary : Middle Cerebral Artery Infarction, also known as infarction, middle cerebral artery, is related to acute myocardial infarction and myocardial infarction. An important gene associated with Middle Cerebral Artery Infarction is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Piracetam and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotype is nervous system.

Related Diseases for Middle Cerebral Artery Infarction

Diseases related to Middle Cerebral Artery Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 29.1 EDN1 PLAT
2 myocardial infarction 28.4 CD40LG EDN1 PLAT S100B
3 cerebritis 11.0
4 hydrops, lactic acidosis, and sideroblastic anemia 10.3
5 intracranial cysts 10.3 ENO2 S100B
6 bednar tumor 10.3 ENO2 S100B
7 epithelioid malignant peripheral nerve sheath tumor 10.3 ENO2 S100B
8 ossifying fibromyxoid tumor 10.3 ENO2 S100B
9 head injury 10.3 ENO2 S100B
10 pineocytoma 10.3 ENO2 S100B
11 papillary ependymoma 10.2 ENO2 S100B
12 subependymal giant cell astrocytoma 10.2 ENO2 S100B
13 granular cell tumor 10.2 ENO2 S100B
14 meningeal melanocytoma 10.2 ENO2 S100B
15 spondylosis 10.2 ENO2 S100B
16 olfactory neuroblastoma 10.2 ENO2 S100B
17 cerebral primitive neuroectodermal tumor 10.2 ENO2 S100B
18 traumatic brain injury 10.2 ENO2 S100B
19 pilomatrixoma 10.2 ENO2 S100B
20 optic nerve glioma 10.2 ENO2 S100B
21 extraosseous ewing's sarcoma 10.2 ENO2 S100B
22 ganglioglioma 10.2 ENO2 S100B
23 brain injury 10.2 ENO2 S100B
24 desmoplastic small round cell tumor 10.2 ENO2 S100B
25 neurilemmoma 10.2 ENO2 S100B
26 clear cell sarcoma 10.2 ENO2 S100B
27 neuroma 10.2 ENO2 S100B
28 hemangioblastoma 10.2 ENO2 S100B
29 brain edema 10.1
30 leiomyosarcoma 10.1 ENO2 S100B
31 gliosarcoma 10.1 ENO2 S100B
32 sleep apnea 10.1 EDN1 S100B
33 cardiac arrest 10.1 ENO2 S100B
34 human immunodeficiency virus infectious disease 10.1 CD40LG S100B
35 creutzfeldt-jakob disease 10.0 ENO2 S100B
36 aging 10.0
37 hydrocephalus 10.0
38 ischemia 10.0
39 glioblastoma 10.0
40 wallerian degeneration 10.0
41 urinary system disease 9.9 CD40LG EDN1
42 eisenmenger syndrome 9.9 EDN1 PLAT
43 acute mountain sickness 9.9 EDN1 ENO2 S100B
44 gastrointestinal stromal tumor 9.9 ENO2 S100B
45 systemic scleroderma 9.9 CD40LG EDN1
46 dressler's syndrome 9.8 CD40LG PLAT
47 secondary progressive multiple sclerosis 9.8 CD40LG ENO2 S100B
48 stroke, ischemic 9.8
49 meningioma, familial 9.8
50 aphasia 9.8

Graphical network of the top 20 diseases related to Middle Cerebral Artery Infarction:



Diseases related to Middle Cerebral Artery Infarction

Symptoms & Phenotypes for Middle Cerebral Artery Infarction

MGI Mouse Phenotypes related to Middle Cerebral Artery Infarction:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 CD40LG EDN1 ENO2 PLAT PLEKHM1

Drugs & Therapeutics for Middle Cerebral Artery Infarction

Drugs for Middle Cerebral Artery Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved, Investigational Phase 4 7491-74-9
2 Pharmaceutical Solutions Phase 4
3
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
4 Epoetin alfa Phase 2, Phase 3 113427-24-0
5 Hematinics Phase 2, Phase 3
6 Tissue Plasminogen Activator Phase 2, Phase 3
7 Anticholesteremic Agents Phase 1, Phase 2
8 Antimetabolites Phase 1, Phase 2
9 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
10 Calcium, Dietary Phase 1, Phase 2
11 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
12 Hypolipidemic Agents Phase 1, Phase 2
13 Lipid Regulating Agents Phase 1, Phase 2
14
Glycerol Approved, Investigational 56-81-5 753
15
Lidocaine Approved, Vet_approved 137-58-6 3676
16 Anesthetics

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
2 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
3 Endovascular Therapy for Acute Ischemic Stroke Trial Completed NCT02350283 Phase 3
4 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
5 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
6 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
7 Application of Contrast Enhance Ultrasound to Evaluate Hemodynamics Change in MCA With Moderate to Severe Stenosis Unknown status NCT01617538 Phase 1, Phase 2 atorvastatin
8 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
9 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
10 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
11 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
12 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
13 A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke Terminated NCT02928393 Phase 2 Basmisanil;Placebo
14 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
15 Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery Unknown status NCT00867581
16 Gait Training for Persons With Stroke Completed NCT00612300 Early Phase 1
17 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
18 ERic Acute StrokE Recanalization (ERASER) Completed NCT02534701
19 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
20 Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery Recruiting NCT02609256
21 tDCS in Acute Stroke Patients Recruiting NCT02806856
22 Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies Active, not recruiting NCT00467103
23 Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy. Not yet recruiting NCT03221959

Search NIH Clinical Center for Middle Cerebral Artery Infarction

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Middle Cerebral Artery Infarction cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Middle Cerebral Artery Infarction:
Neuroncell
Embryonic/Adult Cultured Cells Related to Middle Cerebral Artery Infarction:
Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: infarction, middle cerebral artery

Genetic Tests for Middle Cerebral Artery Infarction

Anatomical Context for Middle Cerebral Artery Infarction

MalaCards organs/tissues related to Middle Cerebral Artery Infarction:

38
Bone, Brain, Bone Marrow, Cortex, Pituitary, Thalamus

Publications for Middle Cerebral Artery Infarction

Articles related to Middle Cerebral Artery Infarction:

(show top 50) (show all 203)
# Title Authors Year
1
Decompressive hemicraniectomy for malignant middle cerebral artery infarction including patients with additional involvement of the anterior and/or posterior cerebral artery territory-outcome analysis and definition of prognostic factors. ( 28965156 )
2018
2
Early Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction in Asian Patients: A Single-Center Study. ( 29317364 )
2018
3
Protein microarray analysis identifies key cytokines associated with malignant middle cerebral artery infarction. ( 28828208 )
2017
4
The Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction. ( 28939676 )
2017
5
Clinical and Radiological Predictors of Malignant Middle Cerebral Artery Infarction Development and Outcomes. ( 28736129 )
2017
6
Decompressive craniectomy for the treatment of malignant middle cerebral artery infarction. ( 28604106 )
2017
7
Massive Middle Cerebral Artery Infarction After Surgically Assisted Rapid Palatal Expansion: A Case Report. ( 28438597 )
2017
8
National Survey of Neurosurgeons and Stroke Physicians on Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 28235642 )
2017
9
Decompressive hemicraniectomy for malignant middle cerebral artery infarction. Experience from the Western Province of Saudi Arabia. ( 28678213 )
2017
10
Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach. ( 29202815 )
2017
11
Predictors of early in-hospital death after decompressive craniectomy in swollen middle cerebral artery infarction. ( 27942881 )
2017
12
Musical, visual and cognitive deficits after middle cerebral artery infarction. ( 29260010 )
2017
13
Malignant middle cerebral artery infarction. ( 28438757 )
2017
14
Pharyngolaryngeal Sensory Deficits in Patients with Middle Cerebral Artery Infarction: Lateralization and Relation to Overall Dysphagia Severity. ( 28972945 )
2017
15
Malignant middle cerebral artery infarction: An unusual but severe neurovascular condition. ( 27147151 )
2016
16
Identification of cytokines for early prediction of malignant middle cerebral artery infarction. ( 26981614 )
2016
17
Clinical course, prognostic factors, and long-term outcomes of malignant middle cerebral artery infarction patients in the modern era. ( 27147150 )
2016
18
Decompressive craniectomy 116a88h after malignant middle cerebral artery infarction. ( 26892675 )
2016
19
Crossed cerebellar diaschisis in patients with acute middle cerebral artery infarction: Occurrence and perfusion characteristics. ( 26661242 )
2016
20
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction. ( 26666449 )
2016
21
Decompressive craniectomy for malignant middle cerebral artery infarction in a 16-year old boy: a case report. ( 27998316 )
2016
22
Large Size Hemicraniectomy Reduces Early Herniation in Malignant Middle Cerebral Artery Infarction. ( 26855236 )
2016
23
Predicting Mortality in Patients With "Malignant" Middle Cerebral Artery Infarction Using Susceptibility-Weighted Magnetic Resonance Imaging: Preliminary Findings. ( 26937906 )
2016
24
Decompressive craniectomy in malignant middle cerebral artery infarction: To be, or not to be? ( 29443256 )
2016
25
Impact of timing of cranioplasty on hydrocephalus after decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 28012353 )
2016
26
Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case-Control Study. ( 27443695 )
2016
27
Neurologic Functional Outcomes of Decompressive Hemicraniectomy Versus Conventional Treatment for Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis. ( 28024976 )
2016
28
10-Year Institutional Retrospective Case Series of Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction (mMCAI). ( 27639522 )
2016
29
Functional Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction and Their Association with Preoperative Thalamus Deformation: An Analysis of 12 Patients. ( 27477404 )
2016
30
Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Infarction: The 'Real World' Beyond Studies. ( 27379413 )
2016
31
Association Between Prolonged Seizures and Malignant Middle Cerebral Artery Infarction in Children With Acute Ischemic Stroke. ( 27663488 )
2016
32
Prediction of Malignant Middle Cerebral Artery Infarction in Elderly Patients. ( 27009609 )
2016
33
De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited. ( 27091344 )
2016
34
Analysis of the Outcome and Prognostic Factors of Decompressive Craniectomy between Young and Elderly Patients for Acute Middle Cerebral Artery Infarction. ( 27847759 )
2016
35
Decompressive craniectomy for severe middle cerebral artery infarction: a meta-analysis of randomised controlled trials. ( 27968912 )
2016
36
Predictive factors for decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 26923797 )
2016
37
Reduction of Midline Shift Following Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 27733025 )
2016
38
Serum malondialdehyde levels in patients with malignant middle cerebral artery infarction are associated with mortality. ( 25933254 )
2015
39
A Right Middle Cerebral Artery Infarct After Frontal Eosinophilic Granuloma Resection in an 8-Year-Old Boy with Factor V Leiden. ( 26442559 )
2015
40
Predictors of malignant brain edema in middle cerebral artery infarction observed on CT angiography. ( 25510537 )
2015
41
Effect of Intravenous Thrombolysis on the Time Course of the Apparent Diffusion Coefficient in Acute Middle Cerebral Artery Infarction. ( 25895155 )
2015
42
Effect of Donepezil on Wernicke Aphasia After Bilateral Middle Cerebral Artery Infarction: Subtraction Analysis of Brain F-18 Fluorodeoxyglucose Positron Emission Tomographic Images. ( 26166237 )
2015
43
Decompressive hemicraniectomy in patients with malignant middle cerebral artery infarction: A systematic review and meta-analysis. ( 25661677 )
2015
44
A Cohort Study of Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction: A Real-World Experience in Clinical Practice. ( 26107675 )
2015
45
Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction. ( 26162891 )
2015
46
Ethical considerations for craniectomy in malignant middle cerebral artery infarction: should we still deny our patient a life-saving procedure? ( 26404880 )
2015
47
The prediction of malignant middle cerebral artery infarction: a predicting approach using random forest. ( 25804564 )
2015
48
Hemicraniectomy in older patients with malignant middle cerebral artery infarction. ( 25681285 )
2015
49
Malignant Middle Cerebral Artery Infarction Resulting from Dissection of Middle Cerebral Artery. ( 26279098 )
2015
50
Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction. ( 26030673 )
2015

Variations for Middle Cerebral Artery Infarction

Expression for Middle Cerebral Artery Infarction

Search GEO for disease gene expression data for Middle Cerebral Artery Infarction.

Pathways for Middle Cerebral Artery Infarction

Pathways related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 EDN1 ENO2

GO Terms for Middle Cerebral Artery Infarction

Cellular components related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CD40LG EDN1 ENO2 PLAT S100B

Biological processes related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 8.62 EDN1 S100B

Molecular functions related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.8 EDN1 PLAT S100B

Sources for Middle Cerebral Artery Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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