MCID: MDD002
MIFTS: 46

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories
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Summaries for Middle Ear Cholesteatoma

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MalaCards based summary: Middle Ear Cholesteatoma, also known as cholesteatoma of the middle ear, is related to cholesteatoma and otitis media. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Defensins and Cytoskeleton remodeling Keratin filaments. The compounds dithranol and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain.

Aliases & Classifications for Middle Ear Cholesteatoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Middle Ear Cholesteatoma, Aliases & Descriptions:

Name: Middle Ear Cholesteatoma 8 62
Cholesteatoma of the Middle Ear 8 62
Cholesteatoma of Middle Ear 8 62
Epidermosis of Middle Ear 8 62
Epidermosis of Ear 8 62
Cholesteatoma of Middle Ear and Mastoid Nos 8
 
Cholesteatoma of Middle Ear and/or Mastoid 8
Cholesteatoma of Middle Ear and Mastoid 8
Cholesterolosis of Middle Ear 8
Cholesteatoma, Unspecified 62
Unspecified Cholesteatoma 8
Cholesteatoma Middle Ear 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Skin diseases


External Ids:

Disease Ontology8 DOID:11433, DOID:10964
MeSH34 D018424
NCIt39 C3654
ICD1025 H71

Related Diseases for Middle Ear Cholesteatoma

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Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma31.5DEFB4A, DEFB1, KRT10, KRT16, KRT13
2otitis media10.5
3oral candidiasis10.4DEFB4A
4epidermolytic acanthoma10.4KRT1
5hypoxia10.4
6first branchial cleft anomaly10.4
7candidiasis10.4DEFB4A
8fibroma10.4KRT1
9osteonecrosis10.3
10osteoporosis10.3
11down syndrome10.3
12cleft palate10.3
13chronic adhesive otitis media10.3
14steatocystoma multiplex10.2KRT16, KRT10
15ichthyosis, cyclic, with epidermolytic hyperkeratosis10.2KRT10, KRT1
16epidermolytic hyperkeratosis10.2KRT10, KRT1
17palmoplantar keratoderma, epidermolytic10.2KRT16, KRT1
18congenital ichthyosiform erythroderma10.2KRT10, KRT1
19tonsillitis10.2DEFB4A, DEFB1
20keratoderma10.2KRT16, KRT1
21duodenal ulcer10.1DEFB1, DEFB4A
22papilloma10.1KRT13, KRT10
23synovial sarcoma10.1KRT1, KRT13
24periodontitis10.1DEFB1, DEFB4A
25skin benign neoplasm10.1KRT1, KRT13
26gastritis10.1DEFB4A, DEFB1
27basal cell carcinoma10.0KRT16, KRT10
28bowen syndrome10.0KRT16, KRT1, KRT10
29periodontal disease10.0DEFB1, DEFB4A
30colitis10.0DEFB1, DEFB4A
31palmoplantar keratosis10.0KRT10, KRT1, KRT16
32cervical cancer10.0DEFB4A, KRT10, KRT1
33epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16
34keratosis10.0KRT10, KRT1, KRT16
35leukoplakia10.0KRT13, KRT1, DEFB4A
36cystic fibrosis9.9DEFB4A, DEFB1, KRT13
37sarcoidosis9.9DEFB4A, DEFB1
38nonepidermolytic palmoplantar keratoderma9.9KRT16, KRT1, KRT10, DEFB4A
39skin disease9.9DEFB4A, KRT10, KRT1, KRT16
40lichen planus9.7KRT13, KRT16, KRT1, KRT10, DEFB4A
41psoriasis9.6DEFB4A, KRT10, KRT1, KRT16, KRT13
42tongue squamous cell carcinoma9.4DEFB4A, DEFB1, KRT10, KRT1, KRT16, KRT13

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Symptoms for Middle Ear Cholesteatoma

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Drugs & Therapeutics for Middle Ear Cholesteatoma

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Drug clinical trials:

Search ClinicalTrials for Middle Ear Cholesteatoma

Search NIH Clinical Center for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

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Anatomical Context for Middle Ear Cholesteatoma

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MalaCards organs/tissues related to Middle Ear Cholesteatoma:

32
Skin, Bone, Brain, Placenta

Animal Models for Middle Ear Cholesteatoma or affiliated genes

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Publications for Middle Ear Cholesteatoma

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Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
2
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
3
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
4
External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review. (24664275)
2014
5
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
6
Apparent diffusion coefficients for detection of postoperative middle ear cholesteatoma on non-echo-planar diffusion-weighted images. (23801772)
2013
7
Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. (23769568)
2013
8
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
9
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
10
Canal wall up tympanoplasty for middle ear cholesteatoma in adults: modeling cartilage. (22226673)
2012
11
Congenital middle ear cholesteatoma. (21086268)
2010
12
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
13
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
14
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
15
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. (17921909)
2007
16
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
17
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
18
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
19
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
20
The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. (16001900)
2005
21
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
22
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
23
Epidermal growth factor expression in middle ear cholesteatoma. (15481560)
2004
24
Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. (15620146)
2004
25
3D micro-CT images of ossicles destroyed by middle ear cholesteatoma. (15224863)
2004
26
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
27
Expression of beta-defensins in human middle ear cholesteatoma. (12701748)
2003
28
The contralateral ear in patients with middle ear cholesteatoma after long-term follow-up. (14509404)
2003
29
Congenital middle ear cholesteatoma: need for early recognition--role of computed tomography scan. (12633921)
2003
30
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
31
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
32
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
33
The clinical evaluations of pathophysiology for congenital middle ear cholesteatoma. (11351288)
2001
34
Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. (11434956)
2001
35
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
36
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
37
Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth? (10445062)
1999
38
Management of labyrinthine fistula in middle ear cholesteatoma. (9519688)
1998
39
Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations. (8865776)
1996
40
Heat shock proteins in middle ear cholesteatoma. (8570255)
1996
41
Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death. (7475882)
1995
42
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
43
Significance of Langerhans' cells in middle ear cholesteatoma. (7871848)
1994
44
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
45
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
46
Sialomucin in middle ear cholesteatoma perimatrix. (1279931)
1992
47
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
48
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990
49
Pathogenesis and surgical treatment of the middle ear cholesteatoma. (286497)
1979
50
Collagenolytic activity in middle ear cholesteatoma. (4303159)
1969

Variations for Middle Ear Cholesteatoma

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Expression for genes affiliated with Middle Ear Cholesteatoma

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Expression patterns in normal tissues for genes affiliated with Middle Ear Cholesteatoma

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Pathways for genes affiliated with Middle Ear Cholesteatoma

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Pathways related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5DEFB1, DEFB4A
29.0KRT13, KRT16, KRT1

Compounds for genes affiliated with Middle Ear Cholesteatoma

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Compounds related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dithranol449.9KRT10, KRT16
2calcipotriol44 61 28 1112.8KRT10, KRT16
3tazarotene44 1110.8KRT10, KRT1
4hbd2449.7DEFB1, DEFB4A
5isoleucine449.7KRT1, KRT10
6hematoxylin449.7KRT1, KRT10
7sodium dodecylsulfate449.4KRT1, KRT16
8isotretinoin44 1110.4KRT10, KRT1, KRT16
91,25 dihydroxy vitamin d3449.3KRT16, KRT10
10retinoid449.3KRT16, KRT1, KRT10
11progesterone44 28 61 24 1113.2KRT1, KRT10, DEFB4A
12dexamethasone44 50 28 1112.1KRT10, DEFB1, DEFB4A
13steroid449.0KRT16, KRT1, KRT10, DEFB4A
14proline448.8KRT13, KRT16, KRT1, KRT10
15paraffin448.5DEFB4A, KRT10, KRT1, KRT16, KRT13
16serine448.3KRT10, KRT1, KRT16, CTSH
17retinoic acid44 248.9KRT13, KRT16, KRT1, KRT10, DEFB1, DEFB4A

GO Terms for genes affiliated with Middle Ear Cholesteatoma

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Cellular components related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.6KRT16, KRT10
2Golgi lumenGO:0057969.2DEFB1, DEFB4A
3keratin filamentGO:0450959.0KRT13, KRT1, KRT10
4extracellular vesicular exosomeGO:0700628.5KRT10, KRT1, KRT16, KRT13

Biological processes related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.5DEFB1, DEFB4A
2defense response to bacteriumGO:0427429.2DEFB1, DEFB4A

Products for genes affiliated with Middle Ear Cholesteatoma

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Sources for Middle Ear Cholesteatoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet