MCID: MDD002
MIFTS: 40

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories

Aliases & Classifications for Middle Ear Cholesteatoma

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Sources:
10Disease Ontology, 65UMLS, 47Novoseek, 36MeSH, 59SNOMED-CT, 42NCIt, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Middle Ear Cholesteatoma:

Name: Middle Ear Cholesteatoma 10 65
Cholesterolosis of Middle Ear 10 65
Cholesteatoma of Middle Ear and Mastoid Nos 10
Cholesteatoma of Middle Ear and/or Mastoid 10
Cholesteatoma of Middle Ear and Mastoid 10
Cholesteatoma of the Middle Ear 10
Cholesteatoma of Middle Ear 10
 
Epidermosis of Middle Ear 10
Unspecified Cholesteatoma 10
Cholesteatoma, Middle Ear 36
Cholesteatoma Middle Ear 47
Epidermosis of Ear 10
Cholesteatoma 65


Classifications:



External Ids:

Disease Ontology10 DOID:11433, DOID:10964
NCIt42 C3654
MeSH36 D018424
ICD1027 H71

Summaries for Middle Ear Cholesteatoma

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MalaCards based summary: Middle Ear Cholesteatoma, also known as cholesterolosis of middle ear, is related to cholesteatoma and otitis media. An important gene associated with Middle Ear Cholesteatoma is IL1A (Interleukin 1, Alpha), and among its related pathways are a6b1 and a6b4 Integrin signaling and Syndecan-4-mediated signaling events. Affiliated tissues include skin, bone and placenta, and related mouse phenotypes are digestive/alimentary and integument.

Related Diseases for Middle Ear Cholesteatoma

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Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma11.4
2otitis media10.6
3mastoiditis10.4
4hypoxia10.4
5first branchial cleft anomaly10.4
6osteoporosis10.3
7osteonecrosis10.3
8chronic adhesive otitis media10.3
9petrositis10.3
10down syndrome10.3
11ischemia10.2IL1A, KRT16
12alopecia universalis10.2ICAM1, IL1A
13methylmalonic aciduria and homocystinuria type cble10.2IL1A, TNFSF11
14liver cirrhosis10.2ICAM1, IL1A, KRT13
15diabetic cataract10.1IL1A, MMP9
16conventional central osteosarcoma10.1ICAM1, IL1A, KRT16
17periodic limb movement disorder10.1ICAM1, KRT13, KRT16
18oral pharyngeal disorders10.1ICAM1, IL1A, MMP1
19congenital methemoglobinemia10.1FGF2, MMP1
20retinal drusen10.1MMP1, MMP9
21wild type attr amyloidosis10.1MMP1, MMP9
22vestibule of mouth cancer10.1FGF2, ICAM1
23carcinoma arising in nasal papillomatosis10.1MMP1, MMP9
24limb deficiencies distal with micrognathia10.1MMP1, MMP9
25benign prostate phyllodes tumor10.1MMP1, MMP9
26adult brain stem glioma10.1MMP1, MMP9
27pancreatic mucinous cystadenoma10.1MMP9, TNFSF11
28thrombocytopenia10.1ICAM1, MMP9
29odontoma10.1MMP1, MMP9
30verrucous nevus acanthokeratolytic10.1ICAM1, MMP9
31psoriatic arthritis10.1IL1A, MMP1, TNFSF11
32synovium cancer10.1ICAM1, MMP1, TNFSF11
33sick building syndrome10.1MMP9, TNFSF11
34pyrimidine metabolic disorder10.1MMP1, MMP9
35chronic hiccups10.0EGF, IL1A
36hepatic vein thrombosis10.0MMP1, MMP9
37morbid obesity10.0MMP1, MMP9
38dominant beta-thalassemia10.0FGF2, TNFSF11
39drug dependence10.0FGF2, MMP9
40brachydactyly - arterial hypertension10.0MMP1, MMP9
41cervical adenoid basal carcinoma10.0FGF2, HIF1A, ICAM1
42microvascular complications of diabetes 510.0FGF2, HIF1A, ICAM1
43polyneuropathy mental retardation acromicria premature menopause10.0ICAM1, IL1A
44anaplastic large cell lymphoma9.9EGF, MMP9
45auricular cancer9.9HIF1A, MMP1, MMP9
46microvascular complications of diabetes 19.9FGF2, ICAM1, MMP9
47keratitis9.9FGF2, ICAM1, MMP9
48pericarditis9.9FGF2, HIF1A
49adenosarcoma of the uterus9.9EGF, MMP9
50periodontitis9.9IL1A, MMP1, MMP9, TNFSF11

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Symptoms for Middle Ear Cholesteatoma

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Drugs & Therapeutics for Middle Ear Cholesteatoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
2Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryRecruitingNCT01584011
3Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Middle Ear Cholesteatoma


Cochrane evidence based reviews: Cholesteatoma, Middle Ear

Genetic Tests for Middle Ear Cholesteatoma

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Anatomical Context for Middle Ear Cholesteatoma

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MalaCards organs/tissues related to Middle Ear Cholesteatoma:

33
Skin, Bone, Placenta, Brain

Animal Models for Middle Ear Cholesteatoma or affiliated genes

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MGI Mouse Phenotypes related to Middle Ear Cholesteatoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6EGF, HIF1A, ICAM1, KRT16, MMP9
2MP:00107718.0EGF, HIF1A, ICAM1, KRT16, MMP9, TNFSF11
3MP:00020067.7FGF2, HIF1A, ICAM1, IL1A, MMP1, MMP9
4MP:00053877.7EGF, HIF1A, ICAM1, IL1A, MMP1, MMP9
5MP:00053766.7FGF2, HIF1A, ICAM1, IL1A, KRT16, MMP1

Publications for Middle Ear Cholesteatoma

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Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 215)
idTitleAuthorsYear
1
Detectability and anatomical correlation of middle ear cholesteatoma using fused thin slice non-echo planar imaging diffusion-weighted image and magnetic resonance cisternography (FTS-nEPID). (26283576)
2015
2
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
3
Long-term surgical and functional outcomes of the intact canal wall technique for middle ear cholesteatoma in the paediatric population. (25709151)
2014
4
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
5
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
6
External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review. (24664275)
2014
7
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
8
Apparent diffusion coefficients for detection of postoperative middle ear cholesteatoma on non-echo-planar diffusion-weighted images. (23801772)
2013
9
Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. (23769568)
2013
10
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
11
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
12
Canal wall up tympanoplasty for middle ear cholesteatoma in adults: modeling cartilage. (22226673)
2012
13
Congenital middle ear cholesteatoma. (21086268)
2010
14
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
15
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
16
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
17
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
18
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
19
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
20
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
21
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
22
The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. (16001900)
2005
23
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
24
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
25
Epidermal growth factor expression in middle ear cholesteatoma. (15481560)
2004
26
Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. (15620146)
2004
27
3D micro-CT images of ossicles destroyed by middle ear cholesteatoma. (15224863)
2004
28
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
29
Expression of beta-defensins in human middle ear cholesteatoma. (12701748)
2003
30
The contralateral ear in patients with middle ear cholesteatoma after long-term follow-up. (14509404)
2003
31
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
32
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
33
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
34
The clinical evaluations of pathophysiology for congenital middle ear cholesteatoma. (11351288)
2001
35
Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. (11434956)
2001
36
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
37
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
38
Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth? (10445062)
1999
39
Management of labyrinthine fistula in middle ear cholesteatoma. (9519688)
1998
40
Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations. (8865776)
1996
41
Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death. (7475882)
1995
42
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
43
Significance of Langerhans' cells in middle ear cholesteatoma. (7871848)
1994
44
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
45
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
46
Sialomucin in middle ear cholesteatoma perimatrix. (1279931)
1992
47
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
48
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990
49
Pathogenesis and surgical treatment of the middle ear cholesteatoma. (286497)
1979
50
Collagenolytic activity in middle ear cholesteatoma. (4303159)
1969

Variations for Middle Ear Cholesteatoma

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Expression for genes affiliated with Middle Ear Cholesteatoma

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Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

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GO Terms for genes affiliated with Middle Ear Cholesteatoma

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Cellular components related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7EGF, FGF2, IL1A, MMP1, MMP9, TNFSF11
2extracellular spaceGO:00056157.4EGF, FGF2, ICAM1, IL1A, LGALS8, MMP9

Biological processes related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1connective tissue replacement involved in inflammatory response wound healingGO:000224810.4HIF1A, IL1A
2response to copper ionGO:004668810.3ICAM1, IL1A
3ERK1 and ERK2 cascadeGO:007037110.3EGF, TNFSF11
4positive regulation of DNA bindingGO:004338810.2EGF, MMP9
5positive regulation of cerebellar granule cell precursor proliferationGO:002194010.2EGF, FGF2
6positive regulation of vascular endothelial growth factor productionGO:001057510.1HIF1A, IL1A
7mammary gland alveolus developmentGO:006074910.1EGF, TNFSF11
8positive regulation of phosphorylationGO:004232710.0EGF, TNFSF11
9positive regulation of mitotic nuclear divisionGO:00458409.8EGF, IL1A
10positive regulation of MAP kinase activityGO:00434069.5EGF, FGF2, TNFSF11
11positive regulation of angiogenesisGO:00457669.5FGF2, HIF1A, IL1A
12angiogenesisGO:00015259.5EGF, FGF2, HIF1A
13positive regulation of ERK1 and ERK2 cascadeGO:00703749.4FGF2, ICAM1, IL1A
14leukocyte migrationGO:00509009.4ICAM1, MMP1, MMP9
15extracellular matrix organizationGO:00301988.3FGF2, ICAM1, MMP1, MMP9

Molecular functions related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.3FGF2, IL1A, TNFSF11

Sources for Middle Ear Cholesteatoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet