MCID: MDD002
MIFTS: 34

Middle Ear Cholesteatoma malady

Ear, Skin categories

Summaries for Middle Ear Cholesteatoma

Sources:
33MalaCards
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MalaCards: Middle Ear Cholesteatoma, also known as cholesteatoma of middle ear and mastoid nos, is related to hypoxia and chronic adhesive otitis media. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Beta defensins. The compounds hematoxylin and hbd2 have been mentioned in the context of this disorder. Related mouse phenotype integument.

Aliases & Classifications for Middle Ear Cholesteatoma

Sources:
8Disease Ontology, 61UMLS, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear, Skin


Aliases & Descriptions:

middle ear cholesteatoma 8 61
cholesteatoma of middle ear and mastoid nos 8
cholesteatoma of middle ear and/or mastoid 8
cholesteatoma of middle ear and mastoid 8
cholesteatoma of the middle ear 8
cholesterolosis of middle ear 8
cholesteatoma of middle ear 8
unspecified cholesteatoma 8
epidermosis of middle ear 8
cholesteatoma middle ear 45
epidermosis of ear 8


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Disease Ontology8 DOID:11433, DOID:10964
NCIt40 C3654
MeSH35 D018424
ICD1025 H71

Related Diseases for Middle Ear Cholesteatoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hypoxia10.4
2chronic adhesive otitis media10.2
3skin disease10.0IL1A
4epidermolytic acanthoma10.0KRT1
5periodontal disease10.0TNFSF11
6oral candidiasis10.0DEFB4A
7epidermolysis bullosa10.0FLG
8candidiasis10.0DEFB4A
9sinusitis10.0DEFB4A
10keratoacanthoma10.0KRT10, IVL
11oral cancer10.0IVL, KRT13
12gingivitis10.0IL1A, TNFSF11
13keratoderma10.0KRT16, KRT1
14esophagitis10.0S100A8
15epidermolytic hyperkeratosis10.0KRT1, KRT10
16ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT1, KRT10
17irritant dermatitis10.0KRT16
18influenza10.0CCL20
19molluscum contagiosum10.0FLG, IVL
20steatocystoma multiplex10.0KRT16, KRT10
21tonsillitis10.0DEFB1, DEFB4A
22palmoplantar keratosis10.0KRT16, KRT1, KRT10
23congenital ichthyosiform erythroderma10.0KRT10, IVL, FLG
24gastritis10.0DEFB4A, DEFB1, S100A8
25meningioma10.0KRT1, PGF
26palmoplantar keratoderma, epidermolytic10.0KRT1, KRT16
27alopecia areata10.0IL1A
28sarcoma10.0LGALS1, PGF
29contact dermatitis10.0FLG, IL1A, KRT16
30pancreatic cancer10.0LGALS1, CCL20
31sjogren's syndrome10.0S100A8
32peptic ulcer10.0S100A8
33pneumonia10.0S100A8, DEFB1, DEFB4A
34allergic rhinitis10.0FLG
35papilloma10.0KRT10, KRT13, IVL, FLG
36leukoplakia10.0FLG, IVL, DEFB4A, KRT1, KRT13
37periodontitis10.0TNFSF11, DEFB1, DEFB4A, IL1A
38nonepidermolytic palmoplantar keratoderma10.0FLG, DEFB4A, KRT16, KRT1, KRT10
39bowen syndrome10.0FLG, IVL, KRT16, KRT1, KRT10
40dermatitis10.0S100A7, FLG, IVL, IL1A, KRT16
41cervical cancer10.0IVL, IL1A, KRT10
42epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16, IVL, FLG
43asthma10.0S100A8, FLG, DEFB1, DEFB4A
44basal cell carcinoma10.0S100A7, IVL, KRT16, KRT10, LGALS1
45duodenitis10.0S100A8
46keratosis10.0FLG, IVL, KRT16, KRT1, KRT10
47stomach cancer10.0S100A8, ICAM2, DEFB4A, PGF
48duodenal ulcer10.0S100A8, DEFB1, DEFB4A
49ichthyosis vulgaris10.0IVL, FLG
50sarcoidosis10.0DEFB1, DEFB4A, IL1A

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Clinical Features for Middle Ear Cholesteatoma

Drugs & Therapeutics for Middle Ear Cholesteatoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Middle Ear Cholesteatoma

Drug clinical trials:

Search ClinicalTrials for Middle Ear Cholesteatoma

Search NIH Clinical Center for Middle Ear Cholesteatoma

Search CenterWatch for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

Anatomical Context for Middle Ear Cholesteatoma

Animal Models for Middle Ear Cholesteatoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Middle Ear Cholesteatoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1LGALS1, KRT1, KRT16, TNFSF11

Publications for Middle Ear Cholesteatoma

Sources:
51PubMed
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Articles related to Middle Ear Cholesteatoma:

idTitleAuthorsYear
1
Does early surgical intervention of middle ear atelectasis improve long-term results and prevent cholesteatoma? (18936347)
2008
2
Congenital middle ear cholesteatoma: need for early recognition--role of computed tomography scan. (12633921)
2003
3
Routine radiography in early cholesteatomatous middle ear disease. (1123566)
1975

Genetic Variations for Middle Ear Cholesteatoma

Expression for genes affiliated with Middle Ear Cholesteatoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Middle Ear Cholesteatoma

Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

Sources:
12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2KRT13, KRT1, KRT16
2
Hide members
10.2DEFB4A, DEFB103B, DEFB1
3
Immune response Bacterial infections in normal airways
Hide members
10.2CCL20, DEFB4A, IL1A
410.2IL1A, TNFSF11, CCL20
5
Hide members
9.9ICAM2, CTSH, DEFB1, DEFB103B, DEFB4A, IL1A

Compounds for genes affiliated with Middle Ear Cholesteatoma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1hematoxylin4510.6KRT10, KRT1, IVL
2hbd24510.6DEFB1, DEFB103B, DEFB4A
3tazarotene45 1111.6S100A8, KRT1, KRT10
4isotretinoin45 1111.6KRT10, KRT1, KRT16
5procollagen4510.6TNFSF11
6polymyxin b4510.6TNFSF11, DEFB1, IL1A
7dithranol4510.6FLG, IVL, KRT16, KRT10
8estrogen4510.6S100A7, IVL, DEFB4A
9flagellin45 2911.6CCL20, S100A8, DEFB4A
10methylcellulose4510.5IVL, IL1A, KRT10
11sodium dodecylsulfate4510.5IVL, IL1A, KRT16, KRT1
12calcipotriol45 60 29 1113.5FLG, IVL, IL1A, KRT16, KRT10
13bromodeoxyuridine4510.5KRT10, KRT1, IVL, FLG
141,25 dihydroxy vitamin d34510.5TNFSF11, IVL, IL1A, KRT16, KRT10
15peptidoglycan45 2911.5DEFB4A, TNFSF11, CCL20
16allergens4510.5IVL, FLG, S100A8, CCL20
17arsenate4510.4FLG, IVL
18nicotine45 50 29 1113.4KRT1, IL1A, IVL, FLG
19urea45 11 2412.4S100A8, TNFSF11, FLG, IVL
20vitamin d4510.4TNFSF11, IVL, IL1A, KRT13, KRT10
21endotoxin4510.4IL1A, DEFB4A, S100A8, CCL20
22rantes4510.4CCL20, S100A8, ICAM2, DEFB4A, IL1A
23heparan sulfate45 2411.4TNFSF11, IVL, DEFB1, LGALS1
24proline4510.4IVL, KRT16, KRT1, KRT13, KRT10
25calcitriol45 60 11 2413.3S100A8, TNFSF11, FLG, IVL, IL1A, KRT16
26git 276010.3IL1A, S100A8
27retinoid4510.3S100A8, FLG, IVL, KRT16, KRT1, KRT10
28sb 20358045 6011.2IL1A, DEFB4A, IVL, TNFSF11
29fatty acid4510.2S100A7, S100A8, IVL, KRT10, LGALS1
30indomethacin45 60 29 1113.2LGALS1, IL1A, PGF, TNFSF11
31steroid4510.2TNFSF11, FLG, IVL, DEFB103B, DEFB4A, KRT16
32dexamethasone45 50 29 1113.2CCL20, S100A8, TNFSF11, DEFB1, DEFB103B, DEFB4A
33gf 109203x45 6011.2KRT10, IVL, FLG
34heparin45 29 11 2413.2TNFSF11, DEFB4A, PGF, IL1A, LGALS1
354-ipp6010.2IL1A, S100A8
36nitric oxide45 11 2412.2CCL20, S100A8, TNFSF11, FLG, PGF, IL1A
37serine4510.1S100A8, TNFSF11, CTSH, FLG, IVL, IL1A
38vegf4510.1TMSB10, IL1A, PGF, IVL, TNFSF11, CCL20
39progesterone45 60 29 11 2414.1DEFB103B, DEFB4A, IL1A, KRT1, KRT10
40lipid4510.1S100A8, TNFSF11, FLG, IVL, DEFB4A, PGF
41oxygen45 2411.0S100A7, S100A8, TNFSF11, IVL, PGF, LGALS1
42paraffin4510.0S100A8, TNFSF11, IVL, DEFB4A, PGF, KRT16
43cysteine4510.0CASP14, S100A8, TNFSF11, CTSH, FLG, IVL
44tyrosine459.9S100A8, ICAM2, TNFSF11, FLG, IVL, DEFB4A
45pd 98,059459.8TNFSF11, IVL, DEFB4A, PGF
46retinoic acid45 2410.8TMSB10, CASP14, S100A7, S100A8, FLG, IVL
47calcium45 50 11 2412.5TNFSF11, ICAM2, S100A8, S100A7, CASP14, CCL20

GO Terms for genes affiliated with Middle Ear Cholesteatoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.2KRT10, KRT16, FLG
2keratin filamentGO:04509510.1KRT10, KRT13, KRT1, CASP14
3extracellular spaceGO:0056159.6CCL20, S100A8, TNFSF11, CTSH, PGF, IL1A
4extracellular regionGO:0055769.4CCL20, S100A7, S100A8, TNFSF11, DEFB1, DEFB4A

Biological processes related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:03021610.3KRT10, IVL, FLG, S100A7
2epidermis developmentGO:00854410.3CASP14, S100A7, KRT16, KRT13
3ERK1 and ERK2 cascadeGO:07037110.3CTSH, TNFSF11
4defense response to bacteriumGO:04274210.2DEFB4A, DEFB1, S100A8, CCL20
5acute inflammatory responseGO:00252610.2S100A8, DEFB1
6positive regulation of angiogenesisGO:04576610.1IL1A, PGF, CTSH
7immune responseGO:00695510.1CCL20, TNFSF11, DEFB1, DEFB4A, IL1A
8chemotaxisGO:0069359.9DEFB4A, DEFB1, CCL20

Molecular functions related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.3S100A8, S100A7
2structural molecule activityGO:0051989.8KRT13, KRT1, IVL, FLG

Products for genes affiliated with Middle Ear Cholesteatoma

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  • Proteins
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  • Antibodies

Sources for Middle Ear Cholesteatoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet