MCID: MDD002
MIFTS: 51

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories

Summaries for Middle Ear Cholesteatoma

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32MalaCards
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MalaCards: Middle Ear Cholesteatoma, also known as cholesteatoma of middle ear and mastoid nos, is related to cholesteatoma and cholesteatoma of attic. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Beta defensins. The compounds hematoxylin and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotype integument.

Aliases & Classifications for Middle Ear Cholesteatoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Skin diseases


Aliases & Descriptions:

middle ear cholesteatoma 8 60
cholesteatoma of middle ear and mastoid nos 8
cholesteatoma of middle ear and/or mastoid 8
cholesteatoma of middle ear and mastoid 8
cholesteatoma of the middle ear 8
cholesterolosis of middle ear 8
cholesteatoma of middle ear 8
unspecified cholesteatoma 8
epidermosis of middle ear 8
cholesteatoma middle ear 44
epidermosis of ear 8


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Disease Ontology8 DOID:11433, DOID:10964
NCIt39 C3654
MeSH34 D018424
ICD1025 H71

Related Diseases for Middle Ear Cholesteatoma

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17GeneCards, 18GeneDecks
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Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma32.0LGALS1, KRT10, KRT13, KRT16, IL1A, DEFB4A
2cholesteatoma of attic10.4
3otitis media10.4
4cholesteatoma of external ear10.2
5chronic adhesive otitis media10.2
6middle ear cholesterol granuloma10.2
7down syndrome10.2
8facial paralysis10.2
9skin disease10.0IL1A
10epidermolytic acanthoma10.0KRT1
11periodontal disease10.0TNFSF11
12oral candidiasis10.0DEFB4A
13epidermolysis bullosa10.0FLG
14candidiasis10.0DEFB4A
15sinusitis10.0DEFB4A
16keratoacanthoma10.0KRT10, IVL
17oral cancer10.0IVL, KRT13
18gingivitis10.0IL1A, TNFSF11
19keratoderma10.0KRT16, KRT1
20esophagitis10.0S100A8
21epidermolytic hyperkeratosis10.0KRT1, KRT10
22ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT1, KRT10
23irritant dermatitis10.0KRT16
24influenza10.0CCL20
25molluscum contagiosum10.0FLG, IVL
26steatocystoma multiplex10.0KRT16, KRT10
27tonsillitis10.0DEFB1, DEFB4A
28palmoplantar keratosis10.0KRT16, KRT1, KRT10
29congenital ichthyosiform erythroderma10.0KRT10, IVL, FLG
30gastritis10.0DEFB4A, DEFB1, S100A8
31meningioma10.0KRT1, PGF
32palmoplantar keratoderma, epidermolytic10.0KRT1, KRT16
33alopecia areata10.0IL1A
34sarcoma10.0LGALS1, PGF
35contact dermatitis10.0FLG, IL1A, KRT16
36pancreatic cancer10.0LGALS1, CCL20
37sjogren's syndrome10.0S100A8
38peptic ulcer10.0S100A8
39pneumonia10.0S100A8, DEFB1, DEFB4A
40allergic rhinitis10.0FLG
41papilloma10.0KRT10, KRT13, IVL, FLG
42leukoplakia10.0FLG, IVL, DEFB4A, KRT1, KRT13
43periodontitis10.0TNFSF11, DEFB1, DEFB4A, IL1A
44nonepidermolytic palmoplantar keratoderma10.0FLG, DEFB4A, KRT16, KRT1, KRT10
45bowen syndrome10.0FLG, IVL, KRT16, KRT1, KRT10
46dermatitis10.0S100A7, FLG, IVL, IL1A, KRT16
47cervical cancer10.0IVL, IL1A, KRT10
48epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16, IVL, FLG
49asthma10.0S100A8, FLG, DEFB1, DEFB4A
50basal cell carcinoma10.0S100A7, IVL, KRT16, KRT10, LGALS1

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Clinical Features for Middle Ear Cholesteatoma

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Drugs & Therapeutics for Middle Ear Cholesteatoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Middle Ear Cholesteatoma

Drug clinical trials:

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Search NIH Clinical Center for Middle Ear Cholesteatoma

Search CenterWatch for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

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Anatomical Context for Middle Ear Cholesteatoma

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32MalaCards
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MalaCards organs/tissues related to Middle Ear Cholesteatoma:

32
Bone, Skin, Brain, Placenta

Animal Models for Middle Ear Cholesteatoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Middle Ear Cholesteatoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1LGALS1, KRT1, KRT16, TNFSF11

Publications for Middle Ear Cholesteatoma

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50PubMed
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Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Expression of the epidermal growth factor system in human middle ear cholesteatoma. (24256036)
2014
2
High-resolution three-dimensional diffusion-weighted imaging of middle ear cholesteatoma at 3.0 T MRI: usefulness of 3D turbo field-echo with diffusion-sensitized driven-equilibrium preparation (TFE-DSDE) compared to single-shot echo-planar imaging. (23701953)
2013
3
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth. (23852020)
2013
4
Clinical characteristics and surgical benefits and problems of chronic otitis media and middle ear cholesteatoma in elderly patients older than 70 years. (22801042)
2012
5
Non echo planar, diffusion-weighted magnetic resonance imaging (periodically rotated overlapping parallel lines with enhanced reconstruction sequence) compared with echo planar imaging for the detection of middle-ear cholesteatoma. (21110910)
2011
6
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
7
Activation of nuclear factor-kappaB and aberrant gene expression of interleukin 6 in middle ear cholesteatoma]. (19558856)
2009
8
Congenital middle ear cholesteatoma in children; retrospective review of 35 cases. (19270825)
2009
9
Apparent diffusion coefficient values of middle ear cholesteatoma differ from abscess and cholesteatoma admixed infection. (19246529)
2009
10
Psoriasin (S100A7), an antimicrobial peptide, is increased in human middle ear cholesteatoma. (19707901)
2009
11
Gelatinolytic activity of matrix metalloproteinases 2 and 9 in middle ear cholesteatoma. (19128667)
2008
12
Expressions of caspase-14 in human middle ear cholesteatoma. (18520823)
2008
13
Analysis of histopathological aspects in acquired middle ear cholesteatoma. (19582339)
2008
14
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
15
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
16
Comparative analysis of the epithelium stroma interaction of acquired middle ear cholesteatoma in children and adults. (17541620)
2007
17
Differentiation between cholesteatoma and inflammatory process of the middle ear, based on contrast-enhanced computed tomography imaging. (17052371)
2007
18
The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma. (17505610)
2007
19
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
20
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
21
Hexosaminidase as a new potential marker for middle ear cholesteatoma. (17052699)
2006
22
Expression of the gap junction proteins connexin 26 and connexin 43 in human middle ear cholesteatoma. (16428189)
2006
23
Overexpression of placenta growth factor in human middle ear cholesteatoma. (16864484)
2006
24
Efficacy of the KTP laser in the treatment of middle ear cholesteatoma. (15793394)
2005
25
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
26
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
27
Brain abscess secondary to the middle ear cholesteatoma: a report of two cases. (15571920)
2004
28
Middle ear cholesteatoma: characteristic CT findings in 64 patients. (15646162)
2004
29
Canal wall down tympanoplasty with canal reconstruction for middle-ear cholesteatoma: post-operative hearing, cholesteatoma recurrence, and status of re-aeration of reconstructed middle-ear cavity. (12816211)
2003
30
Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma. (12533693)
2003
31
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
32
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
33
p53 Expression and keratinocyte hyperproliferation in middle ear cholesteatoma. (12472520)
2002
34
Expression of matrix metalloproteinasa-2,9 in cholesteatoma and middle ear cancer]. (12761978)
2001
35
Stromal expression of matrix metalloprotease-9 in middle ear cholesteatomas. (10993447)
2000
36
Cell proliferation and apoptosis in human middle ear cholesteatoma. (9525508)
1998
37
Argyrophilic nucleolar organizer regions in auditory meatal skin and middle ear cholesteatoma. (9466068)
1997
38
Immunohistochemical studies with middle ear mucosal remnants in cholesteatoma]. (9378670)
1997
39
Kinetic analysis of cell proliferation using bromodeoxyuridine labeling and in situ detection of dying cells in the tympanic membrane and middle ear cholesteatoma. (8937634)
1996
40
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
41
Involvement of interleukin-1 in middle ear cholesteatoma. (7503375)
1995
42
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
43
Functional characterization of middle ear mucosa residues in cholesteatoma samples. (8172304)
1994
44
Incidence of attic retraction after staged intact canal wall tympanoplasty for middle ear cholesteatoma. (1417577)
1992
45
Possible role of interleukin 1 alpha and interleukin 1 beta in the pathogenesis of cholesteatoma of the middle ear. (1384343)
1992
46
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
47
Congenital middle ear cholesteatoma: report of 3 cases. (1799333)
1991
48
An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma. (2472127)
1989
49
Middle-ear cholesteatoma in children--an Indian perspective. (3694028)
1987
50
Results of conservative surgery for middle ear cholesteatoma. (881921)
1977

Genetic Variations for Middle Ear Cholesteatoma

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Expression for genes affiliated with Middle Ear Cholesteatoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Middle Ear Cholesteatoma

Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

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12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2KRT13, KRT1, KRT16
2
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10.2DEFB4A, DEFB103B, DEFB1
3
Immune response Bacterial infections in normal airways
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10.2CCL20, DEFB4A, IL1A
410.2IL1A, TNFSF11, CCL20
5
Hide members
9.9ICAM2, CTSH, DEFB1, DEFB103B, DEFB4A, IL1A

Compounds for genes affiliated with Middle Ear Cholesteatoma

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44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1hematoxylin4410.6KRT10, KRT1, IVL
2hbd24410.6DEFB1, DEFB103B, DEFB4A
3tazarotene44 1111.6S100A8, KRT1, KRT10
4isotretinoin44 1111.6KRT10, KRT1, KRT16
5procollagen4410.6TNFSF11
6polymyxin b4410.6TNFSF11, DEFB1, IL1A
7dithranol4410.6FLG, IVL, KRT16, KRT10
8estrogen4410.6S100A7, IVL, DEFB4A
9flagellin44 2811.6CCL20, S100A8, DEFB4A
10methylcellulose4410.5IVL, IL1A, KRT10
11sodium dodecylsulfate4410.5IVL, IL1A, KRT16, KRT1
12calcipotriol44 59 28 1113.5FLG, IVL, IL1A, KRT16, KRT10
13bromodeoxyuridine4410.5KRT10, KRT1, IVL, FLG
141,25 dihydroxy vitamin d34410.5TNFSF11, IVL, IL1A, KRT16, KRT10
15peptidoglycan44 2811.5DEFB4A, TNFSF11, CCL20
16allergens4410.5IVL, FLG, S100A8, CCL20
17arsenate4410.4FLG, IVL
18nicotine44 49 28 1113.4KRT1, IL1A, IVL, FLG
19urea44 11 2412.4S100A8, TNFSF11, FLG, IVL
20vitamin d4410.4TNFSF11, IVL, IL1A, KRT13, KRT10
21endotoxin4410.4IL1A, DEFB4A, S100A8, CCL20
22rantes4410.4CCL20, S100A8, ICAM2, DEFB4A, IL1A
23heparan sulfate44 2411.4TNFSF11, IVL, DEFB1, LGALS1
24proline4410.4IVL, KRT16, KRT1, KRT13, KRT10
25calcitriol44 59 11 2413.3S100A8, TNFSF11, FLG, IVL, IL1A, KRT16
26git 275910.3IL1A, S100A8
27retinoid4410.3S100A8, FLG, IVL, KRT16, KRT1, KRT10
28sb 20358044 5911.2IL1A, DEFB4A, IVL, TNFSF11
29fatty acid4410.2S100A7, S100A8, IVL, KRT10, LGALS1
30indomethacin44 59 28 1113.2LGALS1, IL1A, PGF, TNFSF11
31steroid4410.2TNFSF11, FLG, IVL, DEFB103B, DEFB4A, KRT16
32dexamethasone44 49 28 1113.2CCL20, S100A8, TNFSF11, DEFB1, DEFB103B, DEFB4A
33gf 109203x44 5911.2KRT10, IVL, FLG
34heparin44 28 11 2413.2TNFSF11, DEFB4A, PGF, IL1A, LGALS1
354-ipp5910.2IL1A, S100A8
36nitric oxide44 11 2412.2CCL20, S100A8, TNFSF11, FLG, PGF, IL1A
37serine4410.1S100A8, TNFSF11, CTSH, FLG, IVL, IL1A
38vegf4410.1TMSB10, IL1A, PGF, IVL, TNFSF11, CCL20
39progesterone44 59 28 11 2414.1DEFB103B, DEFB4A, IL1A, KRT1, KRT10
40lipid4410.1S100A8, TNFSF11, FLG, IVL, DEFB4A, PGF
41oxygen44 2411.0S100A7, S100A8, TNFSF11, IVL, PGF, LGALS1
42paraffin4410.0S100A8, TNFSF11, IVL, DEFB4A, PGF, KRT16
43cysteine4410.0CASP14, S100A8, TNFSF11, CTSH, FLG, IVL
44tyrosine449.9S100A8, ICAM2, TNFSF11, FLG, IVL, DEFB4A
45pd 98,059449.8TNFSF11, IVL, DEFB4A, PGF
46retinoic acid44 2410.8TMSB10, CASP14, S100A7, S100A8, FLG, IVL
47calcium44 49 11 2412.5TNFSF11, ICAM2, S100A8, S100A7, CASP14, CCL20

GO Terms for genes affiliated with Middle Ear Cholesteatoma

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16Gene Ontology
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Cellular components related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.2KRT10, KRT16, FLG
2keratin filamentGO:04509510.1KRT10, KRT13, KRT1, CASP14
3extracellular spaceGO:0056159.6CCL20, S100A8, TNFSF11, CTSH, PGF, IL1A
4extracellular regionGO:0055769.4CCL20, S100A7, S100A8, TNFSF11, DEFB1, DEFB4A

Biological processes related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:03021610.3KRT10, IVL, FLG, S100A7
2epidermis developmentGO:00854410.3CASP14, S100A7, KRT16, KRT13
3ERK1 and ERK2 cascadeGO:07037110.3CTSH, TNFSF11
4defense response to bacteriumGO:04274210.2DEFB4A, DEFB1, S100A8, CCL20
5acute inflammatory responseGO:00252610.2S100A8, DEFB1
6positive regulation of angiogenesisGO:04576610.1IL1A, PGF, CTSH
7immune responseGO:00695510.1CCL20, TNFSF11, DEFB1, DEFB4A, IL1A
8chemotaxisGO:0069359.9DEFB4A, DEFB1, CCL20

Molecular functions related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.3S100A8, S100A7
2structural molecule activityGO:0051989.8KRT13, KRT1, IVL, FLG

Products for genes affiliated with Middle Ear Cholesteatoma

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Sources for Middle Ear Cholesteatoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet