MCID: MDD002
MIFTS: 44

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories

Summaries for Middle Ear Cholesteatoma

About this section


MalaCards based summary: Middle Ear Cholesteatoma, also known as cholesteatoma of the middle ear, is related to cholesteatoma and otitis media. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Defensins and Cytoskeleton remodeling Keratin filaments. The compounds dithranol and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain.

Aliases & Classifications for Middle Ear Cholesteatoma

About this section
Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 40NCIt, 27ICD10
See all sources

Middle Ear Cholesteatoma, Aliases & Descriptions:

Name: Middle Ear Cholesteatoma 10 62
Cholesteatoma of the Middle Ear 10 62
Cholesteatoma of Middle Ear 10 62
Epidermosis of Middle Ear 10 62
Epidermosis of Ear 10 62
Cholesteatoma of Middle Ear and Mastoid Nos 10
 
Cholesteatoma of Middle Ear and/or Mastoid 10
Cholesteatoma of Middle Ear and Mastoid 10
Cholesterolosis of Middle Ear 10
Cholesteatoma, Unspecified 62
Unspecified Cholesteatoma 10
Cholesteatoma Middle Ear 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Skin diseases


External Ids:

Disease Ontology10 DOID:11433, DOID:10964
MeSH35 D018424
NCIt40 C3654
ICD1027 H71

Related Diseases for Middle Ear Cholesteatoma

About this section

Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma32.0DEFB4A, DEFB1, KRT10, KRT16, KRT13
2otitis media10.5
3hypoxia10.4
4first branchial cleft anomaly10.4
5osteoporosis10.3
6osteonecrosis10.3
7chronic adhesive otitis media10.3
8down syndrome10.3
9oral candidiasis10.0DEFB4A
10epidermolytic acanthoma10.0KRT1
11candidiasis10.0DEFB4A
12fibroma10.0KRT1
13steatocystoma multiplex10.0KRT16, KRT10
14ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
15epidermolytic hyperkeratosis10.0KRT10, KRT1
16palmoplantar keratoderma, epidermolytic10.0KRT16, KRT1
17congenital ichthyosiform erythroderma10.0KRT10, KRT1
18tonsillitis10.0DEFB4A, DEFB1
19keratoderma10.0KRT16, KRT1
20acne10.0DEFB4A, DEFB1
21duodenal ulcer10.0DEFB1, DEFB4A
22papilloma10.0KRT13, KRT10
23sarcoma, synovial10.0KRT1, KRT13
24periodontitis10.0DEFB1, DEFB4A
25skin benign neoplasm10.0KRT1, KRT13
26gastritis10.0DEFB4A, DEFB1
27basal cell carcinoma10.0KRT16, KRT10
28bowen syndrome10.0KRT16, KRT1, KRT10
29palmoplantar keratosis10.0KRT10, KRT1, KRT16
30periodontal disease10.0DEFB1, DEFB4A
31colitis10.0DEFB1, DEFB4A
32epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16
33cervical cancer, somatic10.0DEFB4A, KRT10, KRT1
34keratosis10.0KRT10, KRT1, KRT16
35leukoplakia10.0KRT13, KRT1, DEFB4A
36cystic fibrosis10.0DEFB4A, DEFB1, KRT13
37sarcoidosis 110.0DEFB4A, DEFB1
38skin disease10.0DEFB4A, KRT10, KRT1, KRT16
39lichen planus9.9KRT13, KRT16, KRT1, KRT10, DEFB4A
40psoriasis9.9DEFB4A, KRT10, KRT1, KRT16, KRT13
41tongue squamous cell carcinoma9.9DEFB4A, DEFB1, KRT10, KRT1, KRT16, KRT13

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Symptoms for Middle Ear Cholesteatoma

About this section

Drugs & Therapeutics for Middle Ear Cholesteatoma

About this section

Drug clinical trials:

Search ClinicalTrials for Middle Ear Cholesteatoma

Search NIH Clinical Center for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

About this section

Anatomical Context for Middle Ear Cholesteatoma

About this section

MalaCards organs/tissues related to Middle Ear Cholesteatoma:

33
Bone, Skin, Brain, Placenta

Animal Models for Middle Ear Cholesteatoma or affiliated genes

About this section

Publications for Middle Ear Cholesteatoma

About this section

Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
2
Long-term surgical and functional outcomes of the intact canal wall technique for middle ear cholesteatoma in the paediatric population. (25709151)
2014
3
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
4
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
5
External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review. (24664275)
2014
6
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
7
Apparent diffusion coefficients for detection of postoperative middle ear cholesteatoma on non-echo-planar diffusion-weighted images. (23801772)
2013
8
Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. (23769568)
2013
9
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
10
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
11
Canal wall up tympanoplasty for middle ear cholesteatoma in adults: modeling cartilage. (22226673)
2012
12
Congenital middle ear cholesteatoma. (21086268)
2010
13
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
14
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
15
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
16
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
17
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. (17921909)
2007
18
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
19
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
20
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
21
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
22
The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. (16001900)
2005
23
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
24
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
25
Epidermal growth factor expression in middle ear cholesteatoma. (15481560)
2004
26
Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. (15620146)
2004
27
3D micro-CT images of ossicles destroyed by middle ear cholesteatoma. (15224863)
2004
28
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
29
Expression of beta-defensins in human middle ear cholesteatoma. (12701748)
2003
30
The contralateral ear in patients with middle ear cholesteatoma after long-term follow-up. (14509404)
2003
31
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
32
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
33
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
34
The clinical evaluations of pathophysiology for congenital middle ear cholesteatoma. (11351288)
2001
35
Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. (11434956)
2001
36
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
37
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
38
Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth? (10445062)
1999
39
Management of labyrinthine fistula in middle ear cholesteatoma. (9519688)
1998
40
Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations. (8865776)
1996
41
Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death. (7475882)
1995
42
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
43
Significance of Langerhans' cells in middle ear cholesteatoma. (7871848)
1994
44
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
45
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
46
Sialomucin in middle ear cholesteatoma perimatrix. (1279931)
1992
47
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
48
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990
49
Pathogenesis and surgical treatment of the middle ear cholesteatoma. (286497)
1979
50
Collagenolytic activity in middle ear cholesteatoma. (4303159)
1969

Variations for Middle Ear Cholesteatoma

About this section

Expression for genes affiliated with Middle Ear Cholesteatoma

About this section

Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

About this section

Pathways related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5DEFB1, DEFB4A
29.0KRT13, KRT16, KRT1

Compounds for genes affiliated with Middle Ear Cholesteatoma

About this section

Compounds related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dithranol459.9KRT10, KRT16
2calcipotriol45 61 30 1312.8KRT10, KRT16
3tazarotene45 1310.8KRT10, KRT1
4hbd2459.7DEFB1, DEFB4A
5isoleucine459.7KRT1, KRT10
6hematoxylin459.7KRT1, KRT10
7sodium dodecylsulfate459.4KRT1, KRT16
8isotretinoin45 1310.4KRT10, KRT1, KRT16
91,25 dihydroxy vitamin d3459.3KRT16, KRT10
10retinoid459.3KRT16, KRT1, KRT10
11progesterone45 30 61 26 1313.2KRT1, KRT10, DEFB4A
12dexamethasone45 51 30 1312.1KRT10, DEFB1, DEFB4A
13steroid459.0KRT16, KRT1, KRT10, DEFB4A
14proline458.8KRT13, KRT16, KRT1, KRT10
15paraffin458.5DEFB4A, KRT10, KRT1, KRT16, KRT13
16serine458.3KRT10, KRT1, KRT16, CTSH
17retinoic acid45 268.9KRT13, KRT16, KRT1, KRT10, DEFB1, DEFB4A

GO Terms for genes affiliated with Middle Ear Cholesteatoma

About this section

Cellular components related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.6KRT16, KRT10
2Golgi lumenGO:00057969.2DEFB1, DEFB4A
3keratin filamentGO:00450959.0KRT13, KRT1, KRT10
4extracellular vesicular exosomeGO:00700628.5KRT10, KRT1, KRT16, KRT13

Biological processes related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00069359.5DEFB1, DEFB4A
2defense response to bacteriumGO:00427429.2DEFB1, DEFB4A

Products for genes affiliated with Middle Ear Cholesteatoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Middle Ear Cholesteatoma

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet