MCID: MDD002
MIFTS: 38

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories

Aliases & Classifications for Middle Ear Cholesteatoma

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Sources:
9Disease Ontology, 60UMLS, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 25ICD10
See all sources

Middle Ear Cholesteatoma, Aliases & Descriptions:

Name: Middle Ear Cholesteatoma 9 60
Cholesterolosis of Middle Ear 9 60
Cholesteatoma of Middle Ear and Mastoid Nos 9
Cholesteatoma of Middle Ear and/or Mastoid 9
Cholesteatoma of Middle Ear and Mastoid 9
Cholesteatoma of the Middle Ear 9
 
Cholesteatoma of Middle Ear 9
Epidermosis of Middle Ear 9
Unspecified Cholesteatoma 9
Cholesteatoma Middle Ear 43
Epidermosis of Ear 9
Cholesteatoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Skin diseases


External Ids:

Disease Ontology9 DOID:11433, DOID:10964
MeSH33 D018424
NCIt38 C3654
ICD1025 H71

Summaries for Middle Ear Cholesteatoma

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MalaCards based summary: Middle Ear Cholesteatoma, also known as cholesterolosis of middle ear, is related to cholesteatoma and otitis media. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Defensins and Cytoskeleton remodeling Keratin filaments. The compounds dithranol and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain.

Related Diseases for Middle Ear Cholesteatoma

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Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma31.5DEFB4A, DEFB1, KRT10, KRT16, KRT13
2otitis media10.5
3oral candidiasis10.4DEFB4A
4epidermolytic acanthoma10.4KRT1
5hypoxia10.4
6first branchial cleft anomaly10.4
7candidiasis10.4DEFB4A
8fibroma10.3KRT1
9osteoporosis10.3
10osteonecrosis10.3
11chronic adhesive otitis media10.3
12down syndrome10.3
13steatocystoma multiplex10.2KRT16, KRT10
14ichthyosis, cyclic, with epidermolytic hyperkeratosis10.2KRT10, KRT1
15epidermolytic hyperkeratosis10.2KRT10, KRT1
16palmoplantar keratoderma, epidermolytic10.2KRT16, KRT1
17congenital ichthyosiform erythroderma10.2KRT10, KRT1
18tonsillitis10.2DEFB4A, DEFB1
19keratoderma10.2KRT16, KRT1
20acne10.2DEFB4A, DEFB1
21duodenal ulcer10.1DEFB1, DEFB4A
22papilloma10.1KRT13, KRT10
23sarcoma, synovial10.1KRT1, KRT13
24periodontitis10.1DEFB1, DEFB4A
25skin benign neoplasm10.1KRT1, KRT13
26gastritis10.1DEFB4A, DEFB1
27basal cell carcinoma10.0KRT16, KRT10
28bowen syndrome10.0KRT16, KRT1, KRT10
29palmoplantar keratosis10.0KRT10, KRT1, KRT16
30periodontal disease10.0DEFB1, DEFB4A
31colitis10.0DEFB1, DEFB4A
32epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16
33cervical cancer, somatic10.0DEFB4A, KRT10, KRT1
34keratosis10.0KRT10, KRT1, KRT16
35leukoplakia10.0KRT13, KRT1, DEFB4A
36cystic fibrosis9.9DEFB4A, DEFB1, KRT13
37sarcoidosis 19.9DEFB4A, DEFB1
38palmoplantar keratoderma, nonepidermolytic9.9KRT16, KRT1, KRT10, DEFB4A
39skin disease9.9DEFB4A, KRT10, KRT1, KRT16
40lichen planus9.6KRT13, KRT16, KRT1, KRT10, DEFB4A
41psoriasis9.6DEFB4A, KRT10, KRT1, KRT16, KRT13
42tongue squamous cell carcinoma9.4DEFB4A, DEFB1, KRT10, KRT1, KRT16, KRT13

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Symptoms for Middle Ear Cholesteatoma

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Drugs & Therapeutics for Middle Ear Cholesteatoma

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Drug clinical trials:

Search ClinicalTrials for Middle Ear Cholesteatoma

Search NIH Clinical Center for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

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Anatomical Context for Middle Ear Cholesteatoma

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MalaCards organs/tissues related to Middle Ear Cholesteatoma:

31
Bone, Skin, Brain, Placenta

Animal Models for Middle Ear Cholesteatoma or affiliated genes

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Publications for Middle Ear Cholesteatoma

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Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Acquired middle ear cholesteatoma in children with cleft palate: experience from 18 surgical cases. (24690221)
2014
2
Long-term surgical and functional outcomes of the intact canal wall technique for middle ear cholesteatoma in the paediatric population. (25709151)
2014
3
Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. (24551293)
2014
4
Middle Ear Cholesteatoma Treated with a Mastoidectomy: A Systematic Review of the Measures Used. (25193517)
2014
5
External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review. (24664275)
2014
6
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
7
Apparent diffusion coefficients for detection of postoperative middle ear cholesteatoma on non-echo-planar diffusion-weighted images. (23801772)
2013
8
Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. (23769568)
2013
9
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
10
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
11
Canal wall up tympanoplasty for middle ear cholesteatoma in adults: modeling cartilage. (22226673)
2012
12
Congenital middle ear cholesteatoma. (21086268)
2010
13
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
14
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
15
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
16
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
17
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. (17921909)
2007
18
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
19
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
20
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
21
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
22
The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. (16001900)
2005
23
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
24
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
25
Epidermal growth factor expression in middle ear cholesteatoma. (15481560)
2004
26
Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. (15620146)
2004
27
3D micro-CT images of ossicles destroyed by middle ear cholesteatoma. (15224863)
2004
28
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
29
Expression of beta-defensins in human middle ear cholesteatoma. (12701748)
2003
30
The contralateral ear in patients with middle ear cholesteatoma after long-term follow-up. (14509404)
2003
31
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
32
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
33
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
34
The clinical evaluations of pathophysiology for congenital middle ear cholesteatoma. (11351288)
2001
35
Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. (11434956)
2001
36
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
37
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
38
Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth? (10445062)
1999
39
Management of labyrinthine fistula in middle ear cholesteatoma. (9519688)
1998
40
Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations. (8865776)
1996
41
Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death. (7475882)
1995
42
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
43
Significance of Langerhans' cells in middle ear cholesteatoma. (7871848)
1994
44
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
45
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
46
Sialomucin in middle ear cholesteatoma perimatrix. (1279931)
1992
47
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
48
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990
49
Pathogenesis and surgical treatment of the middle ear cholesteatoma. (286497)
1979
50
Collagenolytic activity in middle ear cholesteatoma. (4303159)
1969

Variations for Middle Ear Cholesteatoma

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Expression for genes affiliated with Middle Ear Cholesteatoma

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Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

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Pathways related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5DEFB1, DEFB4A
29.0KRT13, KRT16, KRT1

Compounds for genes affiliated with Middle Ear Cholesteatoma

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Compounds related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dithranol439.9KRT10, KRT16
2calcipotriol43 59 28 1212.8KRT10, KRT16
3tazarotene43 1210.8KRT10, KRT1
4hbd2439.7DEFB1, DEFB4A
5isoleucine439.7KRT1, KRT10
6hematoxylin439.7KRT1, KRT10
7sodium dodecylsulfate439.4KRT1, KRT16
8isotretinoin43 1210.4KRT10, KRT1, KRT16
91,25 dihydroxy vitamin d3439.3KRT16, KRT10
10retinoid439.3KRT16, KRT1, KRT10
11progesterone43 28 59 24 1213.2KRT1, KRT10, DEFB4A
12dexamethasone43 49 28 1212.1KRT10, DEFB1, DEFB4A
13steroid439.0KRT16, KRT1, KRT10, DEFB4A
14proline438.8KRT13, KRT16, KRT1, KRT10
15paraffin438.5DEFB4A, KRT10, KRT1, KRT16, KRT13
16serine438.3KRT10, KRT1, KRT16, CTSH
17retinoic acid43 248.9KRT13, KRT16, KRT1, KRT10, DEFB1, DEFB4A

GO Terms for genes affiliated with Middle Ear Cholesteatoma

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Cellular components related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.6KRT16, KRT10
2Golgi lumenGO:00057969.2DEFB1, DEFB4A
3keratin filamentGO:00450959.0KRT13, KRT1, KRT10
4extracellular vesicular exosomeGO:00700628.5KRT10, KRT1, KRT16, KRT13

Biological processes related to Middle Ear Cholesteatoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00069359.5DEFB1, DEFB4A
2defense response to bacteriumGO:00427429.2DEFB1, DEFB4A

Products for genes affiliated with Middle Ear Cholesteatoma

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Sources for Middle Ear Cholesteatoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet