MCID: MDD002
MIFTS: 45

Middle Ear Cholesteatoma malady

Ear diseases, Skin diseases categories
Download this MalaCard

Summaries for Middle Ear Cholesteatoma

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Middle Ear Cholesteatoma, also known as cholesteatoma of middle ear and mastoid nos, is related to cholesteatoma and otitis media. An important gene associated with Middle Ear Cholesteatoma is DEFB4A (defensin, beta 4A), and among its related pathways are Defensins and Cytoskeleton remodeling Keratin filaments. The compounds dithranol and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain.

Aliases & Classifications for Middle Ear Cholesteatoma

About this section
Sources:
8Disease Ontology, 62UMLS, 45Novoseek, 40NCIt, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Skin diseases


Aliases & Descriptions:

middle ear cholesteatoma 8 62
cholesteatoma of middle ear and mastoid nos 8
cholesteatoma of middle ear and/or mastoid 8
cholesteatoma of middle ear and mastoid 8
cholesteatoma of the middle ear 8
cholesterolosis of middle ear 8
cholesteatoma of middle ear 8
unspecified cholesteatoma 8
epidermosis of middle ear 8
cholesteatoma middle ear 45
epidermosis of ear 8


External Ids:

Disease Ontology8 DOID:11433, DOID:10964
NCIt40 C3654
MeSH35 D018424
ICD1025 H71

Related Diseases for Middle Ear Cholesteatoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Middle Ear Cholesteatoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1cholesteatoma31.9DEFB4A, DEFB1, KRT10, KRT16, KRT13
2otitis media10.5
3hypoxia10.4
4chronic adhesive otitis media10.2
5down syndrome10.2
6first branchial cleft anomaly10.2
7oral candidiasis10.1DEFB4A
8epidermolytic acanthoma10.1KRT1
9candidiasis10.1DEFB4A
10fibroma10.1KRT1
11steatocystoma multiplex10.1KRT16, KRT10
12ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
13epidermolytic hyperkeratosis10.0KRT10, KRT1
14palmoplantar keratoderma, epidermolytic10.0KRT16, KRT1
15congenital ichthyosiform erythroderma10.0KRT10, KRT1
16tonsillitis10.0DEFB4A, DEFB1
17keratoderma10.0KRT16, KRT1
18duodenal ulcer10.0DEFB1, DEFB4A
19papilloma10.0KRT13, KRT10
20synovial sarcoma10.0KRT1, KRT13
21periodontitis10.0DEFB1, DEFB4A
22skin benign neoplasm10.0KRT1, KRT13
23gastritis10.0DEFB4A, DEFB1
24sarcoidosis10.0DEFB4A, DEFB1
25bowen syndrome10.0KRT16, KRT1, KRT10
26palmoplantar keratosis10.0KRT10, KRT1, KRT16
27epidermolysis bullosa simplex10.0KRT10, KRT1, KRT16
28cervical cancer10.0DEFB4A, KRT10, KRT1
29keratosis10.0KRT10, KRT1, KRT16
30leukoplakia10.0KRT13, KRT1, DEFB4A
31periodontal disease10.0DEFB1, DEFB4A
32basal cell carcinoma10.0KRT16, KRT10
33cystic fibrosis10.0DEFB4A, DEFB1, KRT13
34nonepidermolytic palmoplantar keratoderma10.0KRT16, KRT1, KRT10, DEFB4A
35skin disease10.0DEFB4A, KRT10, KRT1, KRT16
36lichen planus9.9KRT13, KRT16, KRT1, KRT10, DEFB4A
37psoriasis9.9DEFB4A, KRT10, KRT1, KRT16, KRT13
38tongue squamous cell carcinoma9.8DEFB4A, DEFB1, KRT10, KRT1, KRT16, KRT13

Graphical network of the top 20 diseases related to Middle Ear Cholesteatoma:



Diseases related to middle ear cholesteatoma

Symptoms for Middle Ear Cholesteatoma

About this section

Drugs & Therapeutics for Middle Ear Cholesteatoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Middle Ear Cholesteatoma

Search NIH Clinical Center for Middle Ear Cholesteatoma

Genetic Tests for Middle Ear Cholesteatoma

About this section

Anatomical Context for Middle Ear Cholesteatoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Middle Ear Cholesteatoma:

33
Skin, Bone, Brain, Placenta

Animal Models for Middle Ear Cholesteatoma or affiliated genes

About this section

Publications for Middle Ear Cholesteatoma

About this section
Sources:
52PubMed
See all sources

Articles related to Middle Ear Cholesteatoma:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Congenital middle ear cholesteatoma: experience from 26 surgical cases. (23815048)
2013
2
Apparent diffusion coefficients for detection of postoperative middle ear cholesteatoma on non-echo-planar diffusion-weighted images. (23801772)
2013
3
Clinical characteristics of patients with labyrinthine fistulae caused by middle ear cholesteatoma. (23769568)
2013
4
Staging primary middle ear cholesteatoma with non-echoplanar (half-Fourier-acquisition single-shot turbo-spin-echo) diffusion-weighted magnetic resonance imaging helps plan surgery in 22 patients: our experience. (22925100)
2012
5
MRI findings of a middle ear cholesteatoma in a dog. (22843826)
2012
6
Canal wall up tympanoplasty for middle ear cholesteatoma in adults: modeling cartilage. (22226673)
2012
7
Congenital middle ear cholesteatoma. (21086268)
2010
8
Computed tomography features of middle ear cholesteatoma in dogs. (20806867)
2010
9
Activation of nuclear factor-kappaB and aberrant gene expression of interleukin 6 in middle ear cholesteatoma]. (19558856)
2009
10
Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma]. (19157151)
2008
11
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. (17419529)
2007
12
Expression patterns of Ki-67 and telomerase activity in middle ear cholesteatoma. (17255888)
2007
13
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. (17921909)
2007
14
The value of single-shot turbo spin-echo diffusion-weighted MR imaging in the detection of middle ear cholesteatoma. (17768611)
2007
15
Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma. (18036420)
2007
16
Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]. (16927804)
2006
17
Expression of RANKL and OPG in middle ear cholesteatoma tissue. (16826057)
2006
18
The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. (16001900)
2005
19
The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. (15499989)
2004
20
Micronucleus frequency in acquired middle ear cholesteatoma. (15513528)
2004
21
Epidermal growth factor expression in middle ear cholesteatoma. (15481560)
2004
22
3D micro-CT images of ossicles destroyed by middle ear cholesteatoma. (15224863)
2004
23
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1. (12567091)
2003
24
Expression of beta-defensins in human middle ear cholesteatoma. (12701748)
2003
25
The contralateral ear in patients with middle ear cholesteatoma after long-term follow-up. (14509404)
2003
26
Congenital middle ear cholesteatoma: need for early recognition--role of computed tomography scan. (12633921)
2003
27
Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. (12768723)
2002
28
Bilateral occurrence of congenital middle ear cholesteatoma. (12447250)
2002
29
p53 Expression and keratinocyte hyperproliferation in middle ear cholesteatoma. (12472520)
2002
30
Hearing results after tympanoplasty in elderly patients with middle ear cholesteatoma. (11813895)
2001
31
The clinical evaluations of pathophysiology for congenital middle ear cholesteatoma. (11351288)
2001
32
Hearing results of canal wall reconstruction tympanoplasty for middle ear cholesteatoma in children. (11434956)
2001
33
Signal transduction pathway in human middle ear cholesteatoma. (10352447)
1999
34
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. (10518363)
1999
35
Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth? (10445062)
1999
36
Management of labyrinthine fistula in middle ear cholesteatoma. (9519688)
1998
37
Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations. (8865776)
1996
38
Heat shock proteins in middle ear cholesteatoma. (8570255)
1996
39
Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death. (7475882)
1995
40
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. (8562031)
1995
41
Significance of Langerhans' cells in middle ear cholesteatoma. (7871848)
1994
42
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study. (7513006)
1994
43
Platelet-derived growth factor in middle ear cholesteatoma. (7917251)
1994
44
Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. (1280020)
1992
45
Sialomucin in middle ear cholesteatoma perimatrix. (1279931)
1992
46
Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. (1671546)
1991
47
Third place--Resident Basic Science Award 1990. Interleukin 1 causing bone destruction in middle ear cholesteatoma. (2174138)
1990
48
An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma. (2472127)
1989
49
Pathogenesis and surgical treatment of the middle ear cholesteatoma. (286497)
1979
50
Collagenolytic activity in middle ear cholesteatoma. (4303159)
1969

Variations for Middle Ear Cholesteatoma

About this section

Expression for genes affiliated with Middle Ear Cholesteatoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Middle Ear Cholesteatoma

Search GEO for disease gene expression data for Middle Ear Cholesteatoma.

Pathways for genes affiliated with Middle Ear Cholesteatoma

About this section
Sources:
50PathCards, 55Reactome, 60Thomson Reuters
See all sources

Pathways related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5DEFB1, DEFB4A
29.0KRT13, KRT16, KRT1

Compounds for genes affiliated with Middle Ear Cholesteatoma

About this section
Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
See all sources

Compounds related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1dithranol459.9KRT10, KRT16
2calcipotriol45 61 29 1112.8KRT10, KRT16
3tazarotene45 1110.8KRT10, KRT1
4hbd2459.7DEFB1, DEFB4A
5isoleucine459.7KRT1, KRT10
6hematoxylin459.7KRT1, KRT10
7sodium dodecylsulfate459.4KRT1, KRT16
8isotretinoin45 1110.4KRT10, KRT1, KRT16
91,25 dihydroxy vitamin d3459.3KRT16, KRT10
10retinoid459.3KRT16, KRT1, KRT10
11progesterone45 29 61 24 1113.2KRT1, KRT10, DEFB4A
12dexamethasone45 51 29 1112.1KRT10, DEFB1, DEFB4A
13steroid459.0KRT16, KRT1, KRT10, DEFB4A
14proline458.8KRT13, KRT16, KRT1, KRT10
15paraffin458.5DEFB4A, KRT10, KRT1, KRT16, KRT13
16serine458.3KRT10, KRT1, KRT16, CTSH
17retinoic acid45 248.9KRT13, KRT16, KRT1, KRT10, DEFB1, DEFB4A

GO Terms for genes affiliated with Middle Ear Cholesteatoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.6KRT16, KRT10
2Golgi lumenGO:0057969.2DEFB1, DEFB4A
3keratin filamentGO:0450959.0KRT13, KRT1, KRT10
4extracellular vesicular exosomeGO:0700628.5KRT10, KRT1, KRT16, KRT13

Biological processes related to Middle Ear Cholesteatoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.5DEFB1, DEFB4A
2defense response to bacteriumGO:0427429.2DEFB1, DEFB4A

Products for genes affiliated with Middle Ear Cholesteatoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Middle Ear Cholesteatoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet