MCID: MDD005
MIFTS: 24

Middle Lobe Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Middle Lobe Syndrome

MalaCards integrated aliases for Middle Lobe Syndrome:

Name: Middle Lobe Syndrome 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2810
MeSH 41 D008878
SNOMED-CT 64 28295001
UMLS 69 C0026069

Summaries for Middle Lobe Syndrome

Disease Ontology : 12 A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

MalaCards based summary : Middle Lobe Syndrome is related to mycobacterium tuberculosis 1 and aspergillosis. An important gene associated with Middle Lobe Syndrome is BANF1 (Barrier To Autointegration Factor 1), and among its related pathways/superpathways is Keratinization. Affiliated tissues include lung.

Related Diseases for Middle Lobe Syndrome

Graphical network of the top 20 diseases related to Middle Lobe Syndrome:



Diseases related to Middle Lobe Syndrome

Symptoms & Phenotypes for Middle Lobe Syndrome

Drugs & Therapeutics for Middle Lobe Syndrome

Search Clinical Trials , NIH Clinical Center for Middle Lobe Syndrome

Cochrane evidence based reviews: middle lobe syndrome

Genetic Tests for Middle Lobe Syndrome

Anatomical Context for Middle Lobe Syndrome

MalaCards organs/tissues related to Middle Lobe Syndrome:

38
Lung

Publications for Middle Lobe Syndrome

Articles related to Middle Lobe Syndrome:

(show top 50) (show all 106)
# Title Authors Year
1
Middle lobe syndrome: An exceptional presentation of concomitant lepidic adenocarcinoma and bronchial anthracofibrosis. ( 29424200 )
2017
2
Middle lobe syndrome: an intriguing presentation of tracheobronchial amyloidosis. ( 28536221 )
2017
3
Infectious Causes of Right Middle Lobe Syndrome. ( 28178715 )
2017
4
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome. ( 28667658 )
2017
5
A case of upper left extremity deep vein thrombosis with right side middle lobe syndrome. ( 28974915 )
2017
6
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome. ( 26844222 )
2016
7
Image Diagnosis: Endobronchial Tuberculosis Masquerading as an Endobronchial Tumor with Presentation as Middle Lobe Syndrome. ( 28080949 )
2016
8
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. ( 27764010 )
2016
9
Right middle lobe torsion after right upper lobectomy in a patient with an undiagnosed middle lobe syndrome. ( 27707504 )
2016
10
Middle lobe syndrome: a singularly rare presentation of complicated pulmonary hydatid disease. ( 27045051 )
2016
11
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome. ( 27807707 )
2016
12
Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis. ( 26379001 )
2015
13
Ten Years' Experience in Surgical Treatment of Right Middle Lobe Syndrome. ( 25753209 )
2015
14
Middle lobe syndrome: a rare presentation of allergic bronchopulmonary aspergillosis. ( 25053632 )
2014
15
Middle lobe syndrome in children today. ( 24630779 )
2014
16
Middle lobe syndrome due to calcified adenopathy. ( 24712018 )
2014
17
Chest MR imaging in the follow-up of pulmonary alterations in paediatric patients with middle lobe syndrome: comparison with chest X-ray. ( 23090250 )
2013
18
Middle lobe syndrome associated with major haemoptysis. ( 23587098 )
2013
19
Surgical treatment of right middle lobe syndrome in children. ( 22347343 )
2012
20
Chronic atelectasis of the left lower lobe: a clinicopathological condition equivalent to middle lobe syndrome. ( 22761114 )
2012
21
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. ( 22377566 )
2012
22
Thoracoscopic lobectomy as a treatment option for persistent middle lobe syndrome in children. ( 20500467 )
2010
23
Chyloptysis with right middle lobe syndrome complicated postoperatively by chylothorax: an unusual cause of right middle lobe syndrome. ( 19399303 )
2009
24
Middle lobe syndrome in the left lower lobe in chronic obstructive pulmonary disease. ( 19517049 )
2009
25
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. ( 20298381 )
2009
26
Endobronchial tuberculosis presenting as right middle lobe syndrome: clinical characteristics and bronchoscopic findings in 22 cases. ( 18729304 )
2008
27
Bronchial anthracofibrosis and tuberculosis presenting as a middle lobe syndrome. ( 18253679 )
2008
28
Bronchial hyperresponsiveness in persistent middle lobe syndrome in childhood. ( 17256771 )
2007
29
Lung cancer arising in association with middle lobe syndrome. ( 16821589 )
2006
30
Editorial: respecting the middle lobe syndrome. ( 16845655 )
2006
31
Middle lobe syndrome as the pulmonary manifestation of primary SjAPgren's syndrome. ( 16548837 )
2006
32
Bronchial hyperresponsiveness, atopy, and bronchoalveolar lavage eosinophils in persistent middle lobe syndrome. ( 16845656 )
2006
33
The role of timely intervention in middle lobe syndrome in children. ( 16236916 )
2005
34
Middle lobe syndrome in children with asthma: review of 56 cases. ( 15281327 )
2004
35
Kaposi's sarcoma: another cause of middle lobe syndrome. ( 11705444 )
2001
36
Improvement in right lung atelectasis (middle lobe syndrome) following administration of low-dose roxithromycin. ( 11287839 )
2001
37
Middle lobe syndrome due to obstructing solitary bronchial papilloma. ( 10630661 )
1999
38
The right middle-lobe syndrome--a case report and review of the literature. ( 9107229 )
1997
39
Not the right middle lobe syndrome? ( 9254755 )
1997
40
Middle lobe syndrome. ( 8644568 )
1996
41
Case report: Blastomyces dermatitidis as a cause of middle lobe syndrome. ( 8853069 )
1996
42
Middle lobe syndrome: a clinicopathological study of 21 patients. ( 7890282 )
1995
43
Outcome after right middle lobe syndrome. ( 7606950 )
1995
44
Allergic bronchopulmonary aspergillosis with middle lobe syndrome and allergic Aspergillus sinusitis. ( 8339813 )
1993
45
Right middle lobe syndrome caused by Mycobacterium fortuitum in a patient with human immunodeficiency virus infection. ( 1631699 )
1992
46
Role of infection in the middle lobe syndrome in asthma. ( 1599294 )
1992
47
Clinical findings in middle lobe syndrome and other processes of pulmonary shrinkage in children (atelectasis syndrome). ( 1747357 )
1991
48
A case of middle lobe syndrome occurring in two sisters. ( 2243453 )
1990
49
Right middle lobe syndrome progressing to death in a 77-year-old woman. ( 3826100 )
1987
50
Right middle lobe syndrome in children. ( 3623806 )
1987

Variations for Middle Lobe Syndrome

Expression for Middle Lobe Syndrome

Search GEO for disease gene expression data for Middle Lobe Syndrome.

Pathways for Middle Lobe Syndrome

Pathways related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CDSN JUP KRT74

GO Terms for Middle Lobe Syndrome

Cellular components related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.67 BANF1 CDSN JUP KRT74
2 intermediate filament GO:0005882 9.32 JUP KRT74
3 cell-cell junction GO:0005911 9.26 CDSN JUP
4 Z disc GO:0030018 9.16 FLNC JUP
5 cornified envelope GO:0001533 8.96 CDSN JUP
6 desmosome GO:0030057 8.62 CDSN JUP

Biological processes related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.16 JUP KRT74
2 cell-cell adhesion GO:0098609 8.96 CDSN JUP
3 cornification GO:0070268 8.8 CDSN JUP KRT74

Molecular functions related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.96 JUP KRT74
2 protein homodimerization activity GO:0042803 8.8 BANF1 CDSN JUP

Sources for Middle Lobe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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