MCID: MDD005
MIFTS: 25

Middle Lobe Syndrome malady

Respiratory diseases category

Aliases & Classifications for Middle Lobe Syndrome

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Aliases & Descriptions for Middle Lobe Syndrome:

Name: Middle Lobe Syndrome 10 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:2810
SNOMED-CT59 28295001
MeSH36 D008878

Summaries for Middle Lobe Syndrome

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Disease Ontology:10 A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. it is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

MalaCards based summary: Middle Lobe Syndrome is related to asthma and aspergillosis. An important gene associated with Middle Lobe Syndrome is KRT74 (Keratin 74, Type II). Affiliated tissues include lung, and related mouse phenotypes are cardiovascular system and integument.

Related Diseases for Middle Lobe Syndrome

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Diseases related to Middle Lobe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1asthma10.4
2aspergillosis10.4
3allergic bronchopulmonary aspergillosis10.4
4tuberculosis10.4
5sarcoma10.3
6lung cancer10.1
7atopy10.1
8sinusitis10.1
9histoplasmosis10.1
10papilloma10.1
11mycobacterium fortuitum10.1
12idiopathic generalized epilepsy9.8CDSN, KRT74
13uterine corpus diffuse leiomyomatosis9.8FLNC, VEGFA
14mitochondrial non-syndromic sensorineural deafness9.8CDSN, KRT74
15malignant oculomotor nerve tumor9.2CDSN, FLNC, JUP, KRT74, VEGFA

Graphical network of diseases related to Middle Lobe Syndrome:



Diseases related to middle lobe syndrome

Symptoms for Middle Lobe Syndrome

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Drugs & Therapeutics for Middle Lobe Syndrome

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Drugs for Middle Lobe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved76851-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2Racepinephrine768
3
4Epinephryl borate768
5Kavanutraceutical1239000-38-85281052

Interventional clinical trials:

idNameStatusNCT IDPhase
1Auriculotherapy in Tension-type Headache Due to Temporomandibular DysfunctionCompletedNCT02309775
2Sleep Apnea in Early to Mid-Stage Alzheimer's DiseaseRecruitingNCT01400542
3Multi-modal Neuroimaging in Alzheimer's DiseaseActive, not recruitingNCT01554202

Search NIH Clinical Center for Middle Lobe Syndrome


Cochrane evidence based reviews: Middle Lobe Syndrome

Genetic Tests for Middle Lobe Syndrome

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Anatomical Context for Middle Lobe Syndrome

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MalaCards organs/tissues related to Middle Lobe Syndrome:

33
Lung

Animal Models for Middle Lobe Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Middle Lobe Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9CDSN, FLNC, JUP, VEGFA
2MP:00107717.7CDSN, FLNC, JUP, VEGFA

Publications for Middle Lobe Syndrome

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Articles related to Middle Lobe Syndrome:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis. (26379001)
2015
2
Middle lobe syndrome due to calcified adenopathy. (24712018)
2014
3
Middle lobe syndrome associated with major haemoptysis. (23587098)
2013
4
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. (22377566)
2012
5
Surgical treatment of right middle lobe syndrome in children. (22347343)
2012
6
Middle lobe syndrome in the left lower lobe in chronic obstructive pulmonary disease. (19517049)
2009
7
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. (20298381)
2009
8
Bronchial anthracofibrosis and tuberculosis presenting as a middle lobe syndrome. (18253679)
2008
9
Endobronchial tuberculosis presenting as right middle lobe syndrome: clinical characteristics and bronchoscopic findings in 22 cases. (18729304)
2008
10
Bronchial hyperresponsiveness in persistent middle lobe syndrome in childhood. (17256771)
2007
11
Middle lobe syndrome in children with asthma: review of 56 cases. (15281327)
2004
12
Kaposi's sarcoma: another cause of middle lobe syndrome. (11705444)
2001
13
Middle lobe syndrome due to obstructing solitary bronchial papilloma. (10630661)
1999
14
Not the right middle lobe syndrome? (9254755)
1997
15
The right middle-lobe syndrome--a case report and review of the literature. (9107229)
1997
16
Allergic bronchopulmonary aspergillosis with middle lobe syndrome and allergic Aspergillus sinusitis. (8339813)
1993
17
Role of infection in the middle lobe syndrome in asthma. (1599294)
1992
18
Right middle lobe syndrome caused by Mycobacterium fortuitum in a patient with human immunodeficiency virus infection. (1631699)
1992
19
A case of middle lobe syndrome occurring in two sisters. (2243453)
1990
20
Right middle lobe syndrome progressing to death in a 77-year-old woman. (3826100)
1987
21
Aetiopathogenesis of middle lobe syndrome--review of 27 cases. (6511721)
1984
22
Right middle lobe syndrome due to an endobronchial angiofibroma. A case report. (6830389)
1983
23
Peripheral middle lobe syndrome. (6611925)
1983
24
Traction diverticula of the esophagus in the middle lobe syndrome. (6786722)
1981
25
Middle lobe syndrome. (7430667)
1980
26
Isolated middle lobe atelectasis: aetiology, pathogenesis, and treatment of the so-called middle lobe syndrome. (7434301)
1980
27
The middle lobe syndrome and its quasi variants. (4810669)
1974
28
Middle lobe syndrome in asthmatic children. (5012331)
1972
29
Middle lobe syndrome and intractable asthma. (5532652)
1970
30
Middle lobe syndrome. (4996247)
1970
31
Spontaneous right chylothorax with middle lobe syndrome. Report of a case. (6038786)
1967
32
The middle lobe syndrome: a clinical study. (5953791)
1966
33
The right middle lobe syndrome, a non-obstructive complex. (5947916)
1966
34
Psittacosis as a cause of middle lobe syndrome: report of two cases. (13900719)
1962
35
Bilateral middle lobe syndrome. (13512135)
1958
36
The correlation of bronchoscopic and bronchographic findings in the middle lobe syndrome. (13606713)
1958
37
The correlation of bronchoscopic and bronchographic findings in the middle lobe syndrome. (13635712)
1958
38
The correlation of bronchoscopic and bronchographic findings in the middle lobe syndrome. (13572232)
1958
39
Middle lobe syndrome. (13467312)
1957
40
The middle lobe syndrome; certain aspects illustrated by several acute cases. (13434914)
1957
41
Middle lobe syndrome. (13308584)
1956
42
The middle lobe syndrome; a review of the anatomic and clinical features. (14376795)
1955
43
Nontuberculous pulmonary disease: the middle lobe syndrome: anatomic and clinical features. (13216865)
1954
44
Middle lobe syndrome produced by foreign body in lower third of esophagus. (13044637)
1953
45
The so-called middle lobe syndrome. (14931380)
1952
46
The middle lobe syndrome and histoplasmosis. (12999422)
1952
47
Traction diverticula of the esophagus in middle lobe syndrome. (14903511)
1952
48
Nonspecific pneumonitis of the left upper lobe ( simulating the middle lobe syndrome and producing an early superior pulmonary sulcus syndrome). (14804710)
1951
49
The middle lobe syndrome. (14826934)
1951
50
Middle lobe syndrome. (18874043)
1948

Variations for Middle Lobe Syndrome

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Expression for genes affiliated with Middle Lobe Syndrome

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Search GEO for disease gene expression data for Middle Lobe Syndrome.

Pathways for genes affiliated with Middle Lobe Syndrome

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GO Terms for genes affiliated with Middle Lobe Syndrome

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Cellular components related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.7JUP, KRT74
2Z discGO:00300189.3FLNC, JUP
3cell-cell junctionGO:00059119.0CDSN, JUP
4desmosomeGO:00300578.7CDSN, JUP

Biological processes related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell junction assemblyGO:00343299.5FLNC, JUP
2cell migrationGO:00164779.3JUP, VEGFA
3single organismal cell-cell adhesionGO:00163378.9CDSN, JUP

Molecular functions related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428038.5CDSN, JUP, VEGFA

Sources for Middle Lobe Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet