MCID: MDD005
MIFTS: 25

Middle Lobe Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Middle Lobe Syndrome

MalaCards integrated aliases for Middle Lobe Syndrome:

Name: Middle Lobe Syndrome 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2810
MeSH 42 D008878
SNOMED-CT 64 28295001
UMLS 69 C0026069

Summaries for Middle Lobe Syndrome

Disease Ontology : 12 A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

MalaCards based summary : Middle Lobe Syndrome is related to tuberculosis and aspergillosis. An important gene associated with Middle Lobe Syndrome is FLNC (Filamin C), and among its related pathways/superpathways is Keratinization. The drugs Epinephrine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include lung.

Related Diseases for Middle Lobe Syndrome

Diseases related to Middle Lobe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 10.0
2 aspergillosis 9.9
3 allergic bronchopulmonary aspergillosis 9.9
4 asthma 9.8
5 chronic pneumonitis of infancy 9.8 CDSN KRT74
6 sarcoma 9.8
7 vesicoureteral reflux 7 9.7 JUP KRT74
8 basophil adenoma 9.7 CDSN KRT74
9 skin fragility-woolly hair syndrome 9.6 JUP KRT74
10 lung cancer 9.6
11 atopy 9.6
12 silicosis 9.6
13 sinusitis 9.6
14 histoplasmosis 9.6
15 papilloma 9.6
16 amyloidosis 9.6
17 mycobacterium fortuitum 9.6
18 loeys-dietz syndrome 5 9.4 JUP KRT74
19 malignant oculomotor nerve tumor 8.0 BANF1 CDSN FLNC JUP KRT74

Graphical network of the top 20 diseases related to Middle Lobe Syndrome:



Diseases related to Middle Lobe Syndrome

Symptoms & Phenotypes for Middle Lobe Syndrome

Drugs & Therapeutics for Middle Lobe Syndrome

Drugs for Middle Lobe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Ethanol Approved 64-17-5 702
3 Racepinephrine Approved
4 Epinephryl borate
5 Kava Nutraceutical 9000-38-8

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Apnea Positive Pressure Long-Term Efficacy Study Completed NCT00051363 Phase 3
2 Auriculotherapy in Tension-type Headache Due to Temporomandibular Dysfunction Completed NCT02309775
3 Sleep Apnea in Early to Mid-Stage Alzheimer's Disease Terminated NCT01400542

Search NIH Clinical Center for Middle Lobe Syndrome

Cochrane evidence based reviews: middle lobe syndrome

Genetic Tests for Middle Lobe Syndrome

Anatomical Context for Middle Lobe Syndrome

MalaCards organs/tissues related to Middle Lobe Syndrome:

39
Lung

Publications for Middle Lobe Syndrome

Articles related to Middle Lobe Syndrome:

(show top 50) (show all 104)
id Title Authors Year
1
Middle lobe syndrome: an intriguing presentation of tracheobronchial amyloidosis. ( 28536221 )
2017
2
Infectious Causes of Right Middle Lobe Syndrome. ( 28178715 )
2017
3
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome. ( 28667658 )
2017
4
Right middle lobe torsion after right upper lobectomy in a patient with an undiagnosed middle lobe syndrome. ( 27707504 )
2016
5
Image Diagnosis: Endobronchial Tuberculosis Masquerading as an Endobronchial Tumor with Presentation as Middle Lobe Syndrome. ( 28080949 )
2016
6
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome. ( 27807707 )
2016
7
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. ( 27764010 )
2016
8
Middle lobe syndrome: a singularly rare presentation of complicated pulmonary hydatid disease. ( 27045051 )
2016
9
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome. ( 26844222 )
2016
10
Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis. ( 26379001 )
2015
11
Ten Years' Experience in Surgical Treatment of Right Middle Lobe Syndrome. ( 25753209 )
2015
12
Middle lobe syndrome in children today. ( 24630779 )
2014
13
Middle lobe syndrome due to calcified adenopathy. ( 24712018 )
2014
14
Middle lobe syndrome: a rare presentation of allergic bronchopulmonary aspergillosis. ( 25053632 )
2014
15
Middle lobe syndrome associated with major haemoptysis. ( 23587098 )
2013
16
Chest MR imaging in the follow-up of pulmonary alterations in paediatric patients with middle lobe syndrome: comparison with chest X-ray. ( 23090250 )
2013
17
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. ( 22377566 )
2012
18
Chronic atelectasis of the left lower lobe: a clinicopathological condition equivalent to middle lobe syndrome. ( 22761114 )
2012
19
Surgical treatment of right middle lobe syndrome in children. ( 22347343 )
2012
20
Thoracoscopic lobectomy as a treatment option for persistent middle lobe syndrome in children. ( 20500467 )
2010
21
Chyloptysis with right middle lobe syndrome complicated postoperatively by chylothorax: an unusual cause of right middle lobe syndrome. ( 19399303 )
2009
22
Middle lobe syndrome in the left lower lobe in chronic obstructive pulmonary disease. ( 19517049 )
2009
23
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. ( 20298381 )
2009
24
Bronchial anthracofibrosis and tuberculosis presenting as a middle lobe syndrome. ( 18253679 )
2008
25
Endobronchial tuberculosis presenting as right middle lobe syndrome: clinical characteristics and bronchoscopic findings in 22 cases. ( 18729304 )
2008
26
Bronchial hyperresponsiveness in persistent middle lobe syndrome in childhood. ( 17256771 )
2007
27
Middle lobe syndrome as the pulmonary manifestation of primary SjAPgren's syndrome. ( 16548837 )
2006
28
Lung cancer arising in association with middle lobe syndrome. ( 16821589 )
2006
29
Bronchial hyperresponsiveness, atopy, and bronchoalveolar lavage eosinophils in persistent middle lobe syndrome. ( 16845656 )
2006
30
Editorial: respecting the middle lobe syndrome. ( 16845655 )
2006
31
The role of timely intervention in middle lobe syndrome in children. ( 16236916 )
2005
32
Middle lobe syndrome in children with asthma: review of 56 cases. ( 15281327 )
2004
33
Kaposi's sarcoma: another cause of middle lobe syndrome. ( 11705444 )
2001
34
Improvement in right lung atelectasis (middle lobe syndrome) following administration of low-dose roxithromycin. ( 11287839 )
2001
35
Middle lobe syndrome due to obstructing solitary bronchial papilloma. ( 10630661 )
1999
36
Not the right middle lobe syndrome? ( 9254755 )
1997
37
The right middle-lobe syndrome--a case report and review of the literature. ( 9107229 )
1997
38
Case report: Blastomyces dermatitidis as a cause of middle lobe syndrome. ( 8853069 )
1996
39
Middle lobe syndrome. ( 8644568 )
1996
40
Outcome after right middle lobe syndrome. ( 7606950 )
1995
41
Middle lobe syndrome: a clinicopathological study of 21 patients. ( 7890282 )
1995
42
Allergic bronchopulmonary aspergillosis with middle lobe syndrome and allergic Aspergillus sinusitis. ( 8339813 )
1993
43
Right middle lobe syndrome caused by Mycobacterium fortuitum in a patient with human immunodeficiency virus infection. ( 1631699 )
1992
44
Role of infection in the middle lobe syndrome in asthma. ( 1599294 )
1992
45
Clinical findings in middle lobe syndrome and other processes of pulmonary shrinkage in children (atelectasis syndrome). ( 1747357 )
1991
46
A case of middle lobe syndrome occurring in two sisters. ( 2243453 )
1990
47
Right middle lobe syndrome progressing to death in a 77-year-old woman. ( 3826100 )
1987
48
Right middle lobe syndrome in children. ( 3623806 )
1987
49
Aetiopathogenesis of middle lobe syndrome--review of 27 cases. ( 6511721 )
1984
50
Peripheral middle lobe syndrome. ( 6611925 )
1983

Variations for Middle Lobe Syndrome

Expression for Middle Lobe Syndrome

Search GEO for disease gene expression data for Middle Lobe Syndrome.

Pathways for Middle Lobe Syndrome

Pathways related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CDSN JUP KRT74

GO Terms for Middle Lobe Syndrome

Cellular components related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.67 BANF1 CDSN JUP KRT74
2 intermediate filament GO:0005882 9.32 JUP KRT74
3 cell-cell junction GO:0005911 9.26 CDSN JUP
4 Z disc GO:0030018 9.16 FLNC JUP
5 cornified envelope GO:0001533 8.96 CDSN JUP
6 desmosome GO:0030057 8.62 CDSN JUP

Biological processes related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 JUP KRT74
2 cornification GO:0070268 8.8 CDSN JUP KRT74

Molecular functions related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.96 JUP KRT74
2 protein homodimerization activity GO:0042803 8.8 BANF1 CDSN JUP

Sources for Middle Lobe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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