MCID: MGR002
MIFTS: 71

Migraine malady

Neuronal diseases category

Summaries for Migraine

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OMIM:46 Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for...157300 more...

MalaCards based summary: Migraine, also known as migraine disorder, is related to hemiplegic migraine and migraine without aura, and has symptoms including autosomal dominant inheritance, photophobia and vomiting. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways are Synaptic transmission ion currents and Endothelin. The compounds triptan and teriparatide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:9 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus:33 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

NINDS:43 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

Wikipedia:64 Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches... more...

Description from OMIM:46 613656

Aliases & Classifications for Migraine

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Sources:
9Disease Ontology, 23GTR, 43NINDS, 46OMIM, 11DISEASES, 44Novoseek, 33MedlinePlus, 61UMLS, 56SNOMED-CT, 28ICD9CM, 34MeSH, 26ICD10
See all sources

Migraine, Aliases & Descriptions:

Name: Migraine 9 43 46 11 44 33
Migraine Disorder 9 61
Migraine Variant 9 61
 
Migraine with 9 23
Migraine Disorders 61
Without Aura 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:6364
ICD9CM28 346
MeSH34 D008881

Related Diseases for Migraine

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Diseases in the Migraine family:

Migraine 8

Diseases related to Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 376)
idRelated DiseaseScoreTop Affiliating Genes
1hemiplegic migraine32.2ATP1A2, SCN1A, CACNA1A
2migraine without aura32.1CACNA1A, ATP1A2
3familial hemiplegic migraine31.9NOTCH3, CACNA1A, SCN1A, ATP1A2
4cluster headache31.4CALCA, CACNA1A
5alternating hemiplegia of childhood31.2ATP1A2
6hemiplegia31.0ATP1A2, CACNA1A
7epilepsy syndrome30.1ATP1A2, SCN1A, CACNA1A
8uterine fibroid29.9ESR1, EDNRA
9migraine with aura11.1
10headache11.0
11sporadic hemiplegic migraine10.7
12cerebritis10.7
13basilar migraine10.6
14patent foramen ovale10.6
15familial hemiplegic migraine type 110.6
16familial hemiplegic migraine type 210.5
17benign familial infantile epilepsy10.5ATP1A2
18ataxia10.5
19blindness10.5
20cadasil10.5
21transient global amnesia10.5
22dravet syndrome10.4SCN1A
23familial hemiplegic migraine type 310.4
24neuronitis10.4
25cyclic vomiting syndrome10.4
26episodic ataxia10.4
27motion sickness10.4
28idiopathic generalized epilepsy10.4CACNA1A, SCN1A
29restless legs syndrome10.4
30retinitis10.4
31endotheliitis10.3
32hypertension10.3
33scotoma10.3
34meningitis10.3
35sturge-weber syndrome10.3
36weber syndrome10.3
37arteriovenous malformation10.2
38meniere's disease10.2
39cerebellar ataxia10.2
40obesity10.2
41fibromyalgia10.2
42cervicitis10.2
43ophthalmoplegia10.2
44episodic ataxia type 210.2
45occipital neuralgia10.2
46tolosa-hunt syndrome10.1
47intracranial hypertension10.1
48ischemia10.1
49hemicrania continua10.1
50trochleitis10.1

Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Symptoms for Migraine

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Symptoms by clinical synopsis from OMIM:

157300

Clinical features from OMIM:

613656,157300

HPO human phenotypes related to Migraine:

(show all 7)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 photophobia HP:0000613
3 vomiting HP:0002013
4 nausea HP:0002018
5 migraine with aura HP:0002077
6 migraine without aura HP:0002083
7 phonophobia HP:0002183

Drugs & Therapeutics for Migraine

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Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Genetic Tests for Migraine

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Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine23

Anatomical Context for Migraine

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MalaCards organs/tissues related to Migraine:

32
Brain, Cortex, Endothelial, Testes, Heart, Liver, Thalamus, Pituitary, Monocytes, Trigeminal ganglion, Cerebellum, Smooth muscle, Occipital lobe, Hypothalamus, Amygdala, Tongue, Pineal

Animal Models for Migraine or affiliated genes

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MGI Mouse Phenotypes related to Migraine:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5ESR1, EDNRA, ATP1A2, CACNA1A, CALCA, NOTCH3
2MP:00053699.5NOTCH3, EDNRA, ATP1A2, ESR1, HTR1B, CACNA1A
3MP:00053869.3NOTCH3, ATP1A2, SCN1A, ESR1, HTR1B, CACNA1A
4MP:00028739.2ATP1A2, NOTCH3, CALCA, CACNA1A, SCN1A, EDNRA
5MP:00036319.0CALCA, CACNA1A, ESR1, SCN1A, KCNK18, ATP1A2

Publications for Migraine

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Articles related to Migraine:

(show top 50)    (show all 2180)
idTitleAuthorsYear
1
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
2
Nutraceuticals for the prevention of migraine in children: Do we know what the benefits and the risks are? (24436462)
2014
3
Migraine: Nasal sumatriptan could provide quick relief for migraine. (25404512)
2014
4
Discussion: nonendoscopic deactivation of nerve triggers in migraine headache patients: surgical technique and outcomes. (25357036)
2014
5
Editorial: TRIGGERS and Premonitory Features in Migraine. (25399859)
2014
6
Is migraine a disorder of the central nervous system? (23695042)
2013
7
Angiotensin I-converting enzyme gene (I/D) polymorphism in patients with migraine. (23278516)
2013
8
Genetic variants in the NOTCH4 gene influence the clinical features of migraine. (23566281)
2013
9
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
10
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
11
Casein kinase idelta mutations in familial migraine and advanced phase. (23636092)
2013
12
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
13
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
14
Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. (23797675)
2013
15
Association analysis of STX1A gene variants in common forms of migraine. (22250207)
2012
16
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
17
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
18
Migraine: Role of the TRESK two-pore potassium channel. (21855646)
2011
19
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
20
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
21
Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. (19673915)
2010
22
Migraine may be a risk factor for the development of complex regional pain syndrome. (19614690)
2010
23
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
24
The mechanism of peripheral and central sensitization in migraine. A literature review]. (19731814)
2009
25
Lack of association of hormone receptor polymorphisms with migraine. (19175383)
2009
26
Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. (19911463)
2009
27
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
28
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
29
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
30
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
31
Childhood steroid-responsive painful ophthalmoplegia: clues to ophthalmoplegic migraine. (17643751)
2007
32
Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. (17927652)
2007
33
Hemifacial spasm induced by trigeminal stimuli and coupled with ipsilateral migraine: a spasmodic migraine. (16919068)
2006
34
Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. (16472331)
2006
35
Acute aseptic meningitis inducing migraine-like attacks in a 7-year-old child. (16722988)
2006
36
Calcitonin gene-related peptide (CGRP) and migraine. (16927957)
2006
37
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
38
CGRP and migraine: neurogenic inflammation revisited. (16362644)
2005
39
No mutations in CACNA1A and ATP1A2 in probands with common types of migraine. (15210532)
2004
40
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
41
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
42
A typical migraine susceptibility region localizes to chromosome 1q31. (12030327)
2002
43
CGRP may play a causative role in migraine. (11993614)
2002
44
Development of CGRP antagonists for the treatment of migraine. (11717813)
2001
45
Chiropractic management of migraine without aura. A case study. (17987195)
1999
46
Role of magnesium in the pathogenesis and treatment of migraines. (9523054)
1998
47
Searching for migraine genes: exclusion of 290 cM out of the whole human genome. (9412851)
1997
48
Acute confusional migraine: variant of transient global amnesia. (7779209)
1995
49
Lack of association between anticardiolipin antibodies and migraine in systemic lupus erythematosus. (1549239)
1992
50
Migraine and anticardiolipin antibodies--case reports of 13 patients, and the prevalence of antiphospholipid antibodies in migraineurs. (1960059)
1991

Variations for Migraine

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Expression for genes affiliated with Migraine

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Expression patterns in normal tissues for genes affiliated with Migraine

Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

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Compounds for genes affiliated with Migraine

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Compounds related to Migraine according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1triptan4410.4HTR1B, CALCA
2teriparatide44 1211.4CALCA, ESR1
3rizatriptan44 29 1212.3HTR1B, CALCA
4ibandronate44 1211.3CALCA, ESR1
5risedronate44 50 29 60 1214.3CALCA, ESR1
6n(g)-nitro-l-arginine methyl ester4410.3CALCA, EDNRA
7tetrodotoxin44 60 2912.2CALCA, SCN1A, EDNRA
8tibolone4410.2CALCA, ESR1
9sumatriptan44 29 60 50 25 1215.1CALCA, HTR1B
10phosphoramidon44 1211.0EDNRA, CALCA
11sodium44 2511.0EDNRA, ATP1A2, SCN1A, CACNA1A
12potassium44 25 1212.0CACNA1A, SCN1A, KCNK18, ATP1A2, EDNRA
13alendronate44 50 1211.8CALCA, ESR1
14testosterone44 60 25 1212.8CALCA, HTR1B, ESR1, EDNRA

GO Terms for genes affiliated with Migraine

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Cellular components related to Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.0CALCA, CACNA1A, SCN1A
2T-tubuleGO:0303159.9SCN1A, ATP1A2, EDNRA
3plasma membraneGO:0058868.5EDNRA, ATP1A2, KCNK18, ESR1, PRRT2, HTR1B

Biological processes related to Migraine according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cAMP biosynthetic processGO:03081810.3EDNRA, HTR1B
2neuromuscular process controlling postureGO:05088410.3PRRT2, SCN1A
3G-protein coupled receptor internalizationGO:00203110.2HTR1B, CALCA
4positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.2CALCA, EDNRA
5regulation of blood pressureGO:00821710.2EDNRA, ATP1A2, CALCA
6adult walking behaviorGO:00762810.2CACNA1A, SCN1A
7vasoconstrictionGO:04231010.2HTR1B, EDNRA
8positive regulation of cytosolic calcium ion concentrationGO:00720410.1CALCA, CACNA1A, ESR1, EDNRA
9activation of adenylate cyclase activityGO:00719010.0EDNRA, CALCA
10protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.9HTR1B, EDNRA

Products for genes affiliated with Migraine

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Sources for Migraine

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet