MCID: MGR002
MIFTS: 64

Migraine malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Migraine

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Migraine, Aliases & Descriptions:

Name: Migraine 45 9 42 11 43 32
Migraine Without Aura 45 9 11
Common Migraine 9 43 60
Migraine Variant 9 60
Migraine with 9 22
 
Migraine with or Without Aura, Susceptibility to, 1 10
Migraine Disorders 60
Migraine Disorder 9
Without Aura 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


Summaries for Migraine

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OMIM:45 Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for... (157300) more...

MalaCards based summary: Migraine, also known as migraine without aura, is related to hemiplegic migraine and familial hemiplegic migraine, and has symptoms including autosomal dominant inheritance, photophobia and vomiting. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and Thyroid hormone signaling pathway. The compounds triptan and teriparatide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:9 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MedlinePlus:32 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

NINDS:42 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

Wikipedia:63 Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often... more...

Related Diseases for Migraine

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Diseases related to Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 380)
idRelated DiseaseScoreTop Affiliating Genes
1hemiplegic migraine32.3SCN1A, ATP1A2, CACNA1A
2familial hemiplegic migraine32.0NOTCH3, CACNA1A, SCN1A, ATP1A2
3cluster headache31.5CACNA1A, CALCA
4alternating hemiplegia of childhood31.2ATP1A2
5hemiplegia31.0ATP1A2, CACNA1A
6complex regional pain syndrome30.8CALCA
7benign familial infantile epilepsy30.5ATP1A2
8epilepsy syndrome30.4CACNA1A, ATP1A2, SCN1A
9migraine with aura11.1
10headache11.0
11sporadic hemiplegic migraine10.7
12cerebritis10.7
13basilar migraine10.6
14patent foramen ovale10.6
15ataxia10.5
16blindness10.5
17migraine, familial hemiplegic, 210.5
18migraine, familial hemiplegic, 110.5
19transient global amnesia10.5
20migraine, familial hemiplegic, 310.5
21cadasil10.5
22vascular dementia10.4NOTCH3
23dravet syndrome10.4SCN1A
24episodic ataxia10.4
25neuronitis10.4
26cyclic vomiting syndrome10.4
27epilepsy, idiopathic generalized10.4SCN1A, CACNA1A
28motion sickness10.4
29endotheliitis10.4
30restless legs syndrome10.3
31retinitis10.3
32scotoma10.3
33meniere's disease10.3
34meningitis10.3
35weber syndrome10.3
36episodic ataxia, type 210.2
37obesity10.2
38cerebellar ataxia10.2
39arteriovenous malformation10.2
40fibromyalgia10.2
41ophthalmoplegia10.2
42occipital neuralgia10.2
43breast ductal carcinoma10.2ESR1, EDNRA
44tolosa-hunt syndrome10.1
45cervicitis10.1
46intracranial hypertension10.1
47ischemia10.1
48hemicrania continua10.1
49trochleitis10.1
50aneurysm10.1

Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Symptoms for Migraine

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Symptoms by clinical synopsis from OMIM:

157300

Clinical features from OMIM:

157300

HPO human phenotypes related to Migraine:

(show all 7)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 photophobia HP:0000613
3 vomiting HP:0002013
4 nausea HP:0002018
5 migraine with aura HP:0002077
6 migraine without aura HP:0002083
7 phonophobia HP:0002183

Drugs & Therapeutics for Migraine

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Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Genetic Tests for Migraine

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Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine22

Anatomical Context for Migraine

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MalaCards organs/tissues related to Migraine:

31
Brain, Endothelial, Cortex, Testes, Heart, Liver, Thalamus, Pituitary, Monocytes, Trigeminal ganglion, Cerebellum, Smooth muscle, Kidney, T cells, Occipital lobe, Hypothalamus, Amygdala, Tongue, Pineal

Animal Models for Migraine or affiliated genes

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Publications for Migraine

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Articles related to Migraine:

(show top 50)    (show all 2227)
idTitleAuthorsYear
1
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
2
Nutraceuticals for the prevention of migraine in children: Do we know what the benefits and the risks are? (24436462)
2014
3
Migraine: Nasal sumatriptan could provide quick relief for migraine. (25404512)
2014
4
Discussion: nonendoscopic deactivation of nerve triggers in migraine headache patients: surgical technique and outcomes. (25357036)
2014
5
Editorial: TRIGGERS and Premonitory Features in Migraine. (25399859)
2014
6
Is migraine a disorder of the central nervous system? (23695042)
2013
7
Angiotensin I-converting enzyme gene (I/D) polymorphism in patients with migraine. (23278516)
2013
8
Genetic variants in the NOTCH4 gene influence the clinical features of migraine. (23566281)
2013
9
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
10
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
11
Casein kinase idelta mutations in familial migraine and advanced phase. (23636092)
2013
12
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
13
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
14
Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. (23797675)
2013
15
Association analysis of STX1A gene variants in common forms of migraine. (22250207)
2012
16
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
17
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
18
Migraine: Role of the TRESK two-pore potassium channel. (21855646)
2011
19
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
20
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
21
Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. (19673915)
2010
22
Migraine may be a risk factor for the development of complex regional pain syndrome. (19614690)
2010
23
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
24
The mechanism of peripheral and central sensitization in migraine. A literature review]. (19731814)
2009
25
Lack of association of hormone receptor polymorphisms with migraine. (19175383)
2009
26
Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. (19911463)
2009
27
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
28
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
29
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
30
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
31
Childhood steroid-responsive painful ophthalmoplegia: clues to ophthalmoplegic migraine. (17643751)
2007
32
Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. (17927652)
2007
33
Hemifacial spasm induced by trigeminal stimuli and coupled with ipsilateral migraine: a spasmodic migraine. (16919068)
2006
34
Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. (16472331)
2006
35
Acute aseptic meningitis inducing migraine-like attacks in a 7-year-old child. (16722988)
2006
36
Calcitonin gene-related peptide (CGRP) and migraine. (16927957)
2006
37
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
38
CGRP and migraine: neurogenic inflammation revisited. (16362644)
2005
39
No mutations in CACNA1A and ATP1A2 in probands with common types of migraine. (15210532)
2004
40
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
41
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
42
A typical migraine susceptibility region localizes to chromosome 1q31. (12030327)
2002
43
CGRP may play a causative role in migraine. (11993614)
2002
44
Development of CGRP antagonists for the treatment of migraine. (11717813)
2001
45
Chiropractic management of migraine without aura. A case study. (17987195)
1999
46
Role of magnesium in the pathogenesis and treatment of migraines. (9523054)
1998
47
Searching for migraine genes: exclusion of 290 cM out of the whole human genome. (9412851)
1997
48
Acute confusional migraine: variant of transient global amnesia. (7779209)
1995
49
Lack of association between anticardiolipin antibodies and migraine in systemic lupus erythematosus. (1549239)
1992
50
Migraine and anticardiolipin antibodies--case reports of 13 patients, and the prevalence of antiphospholipid antibodies in migraineurs. (1960059)
1991

Variations for Migraine

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Expression for genes affiliated with Migraine

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Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

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Pathways related to Migraine according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CALCA, EDNRA
210.1NOTCH3, ESR1, ATP1A2
3
Show member pathways
9.8CACNA1A, HTR3D, HTR1B, SCN1A

Compounds for genes affiliated with Migraine

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Compounds related to Migraine according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1triptan4310.4CALCA, HTR1B
2teriparatide43 1211.4CALCA, ESR1
3toxin-14310.4TNF, EDNRA
4rizatriptan43 28 1212.4CALCA, HTR1B
5ibandronate43 1211.4ESR1, CALCA
6risedronate43 49 28 59 1214.4ESR1, CALCA
7tetrodotoxin43 59 2812.3EDNRA, SCN1A, CALCA
8n(g)-nitro-l-arginine methyl ester4310.3CALCA, EDNRA
9tibolone4310.3ESR1, CALCA
10alendronate43 49 1212.2CALCA, ESR1
11sumatriptan43 28 59 49 24 1215.2CALCA, HTR1B
12sodium43 2411.1CACNA1A, SCN1A, ATP1A2, EDNRA
13phosphoramidon43 1211.1CALCA, EDNRA
14potassium43 24 1212.1CACNA1A, SCN1A, KCNK18, ATP1A2, EDNRA
15leflunomide43 49 1211.9ESR1, TNF

GO Terms for genes affiliated with Migraine

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Cellular components related to Migraine according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1T-tubuleGO:00303159.8EDNRA, ATP1A2, SCN1A
2plasma membraneGO:00058869.0EDNRA, ATP1A2, KCNK18, TNF, ESR1, PRRT2

Biological processes related to Migraine according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cAMP biosynthetic processGO:003081810.4EDNRA, HTR1B
2neuromuscular process controlling postureGO:005088410.4PRRT2, SCN1A
3G-protein coupled receptor internalizationGO:000203110.3CALCA, HTR1B
4positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:005148210.3EDNRA, CALCA
5regulation of blood pressureGO:000821710.3ATP1A2, EDNRA, CALCA
6vasoconstrictionGO:004231010.3EDNRA, HTR1B
7positive regulation of nitric oxide biosynthetic processGO:004542910.2ESR1, TNF
8adult walking behaviorGO:000762810.2CACNA1A, SCN1A
9positive regulation of cytosolic calcium ion concentrationGO:000720410.2ESR1, EDNRA, CALCA, CACNA1A
10activation of adenylate cyclase activityGO:000719010.1EDNRA, CALCA
11protein kinase C-activating G-protein coupled receptor signaling pathwayGO:00072059.9HTR1B, EDNRA

Products for genes affiliated with Migraine

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Sources for Migraine

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet