MCID: MGR002
MIFTS: 71

Migraine malady

Neuronal diseases category

Summaries for Migraine

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

MalaCards: Migraine, also known as migraine disorder, is related to migraine without aura and familial hemiplegic migraine. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways is Circadian entrainment. The compounds potassium and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related mouse phenotypes are nervous system and respiratory system.

Disease Ontology:8 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus:33 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

Wikipedia:63 Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches... more...

Description from OMIM:46 157300

Aliases & Classifications for Migraine

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Sources:
8Disease Ontology, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

migraine 8 43 46 10 44 33
migraine disorder 8 22
migraine variant 8 60
migraine disorders 60


Related Diseases for Migraine

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Migraine family:

Migraine 8

Diseases related to Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1migraine without aura31.4ATP1A2, CACNA1A
2familial hemiplegic migraine31.4ATP1A2, SCN1A, CACNA1A, NOTCH3
3hemiplegic migraine30.4CACNA1A, SCN1A, ATP1A2
4hypertension30.4EDNRA, CALCA
5alternating hemiplegia of childhood30.3ATP1A2
6hemiplegia30.2CACNA1A, ATP1A2
7ischemia30.1EDNRA, DRD2, ATP1A2
8personality disorder29.8DRD2, HTR1B
9bipolar disorder29.8DRD2
10cluster headache29.6CALCA, CACNA1A
11obsessive-compulsive disorder29.6DRD2, HTR1B
12paraganglioma29.6CALCA
13migraine with aura11.1
14cerebritis10.6
15patent foramen ovale10.6
16familial hemiplegic migraine type 110.4
17cadasil10.4
18transient global amnesia10.4
19familial hemiplegic migraine type 210.4
20familial hemiplegic migraine type 310.4
21basilar migraine10.4
22neuronitis10.4
23episodic ataxia10.3
24motion sickness10.3
25sporadic hemiplegic migraine10.3
26restless legs syndrome10.3
27retinitis10.3
28scotoma10.2
29meniere's disease10.2
30meningitis10.2
31stroke, ischemic10.2
32arteriovenous malformation10.2
33obesity10.2
34vestibular disease10.2
35cerebellar ataxia10.1
36cervicitis10.1
37glaucoma10.1
38ophthalmoplegia10.1
39episodic ataxia type 210.1
40tolosa-hunt syndrome10.1
41intracranial hypertension10.1
42mitral valve prolapse10.0
43low tension glaucoma10.0
44carotid artery dissection10.0
45post-traumatic stress disorder10.0
46cerebrovascular disease10.0
47complex regional pain syndrome10.0
48epilepsy syndrome10.0
49multiple sclerosis10.0
50neuropathy10.0

Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Clinical Features for Migraine

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Sources:
46OMIM
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Clinical features from OMIM:

157300

Clinical synopsis from OMIM:

157300

Drugs & Therapeutics for Migraine

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Migraine

Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Search CenterWatch for Migraine

Genetic Tests for Migraine

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Sources:
22GTR
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Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine22

Anatomical Context for Migraine

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Sources:
32MalaCards
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MalaCards organs/tissues related to Migraine:

32
Brain, Endothelial, Cortex, Testes, Heart, Liver, Pituitary, Thalamus, Monocytes, Trigeminal ganglion, Amygdala, Tongue, Smooth muscle, Pineal, Hypothalamus, T cells, Cerebellum, Occipital lobe, Kidney

Animal Models for Migraine or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Migraine:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3CALCA, CACNA1A, SCN1A, DRD2, EDNRA, ATP1A2
2MP:000538811.0ESR1, CALCA, CACNA1A, DRD2, EDNRA, ATP1A2
3MP:000536910.8CACNA1A, HTR1B, DRD2, EDNRA, ATP1A2, NOTCH3

Publications for Migraine

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Sources:
50PubMed
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Articles related to Migraine:

(show top 50)    (show all 2109)
idTitleAuthorsYear
1
Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: A randomized study. (24363238)
2014
2
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
3
Bloody migraine? (24085023)
2013
4
Asynchronicity of facial blood perfusion in migraine. (24324592)
2013
5
Migraine and epilepsy: progress towards preemptive therapy. (23731571)
2013
6
Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: a retrospective study in Japan. (24074550)
2013
7
Genome-wide meta-analysis identifies new susceptibility loci for migraine. (23793025)
2013
8
Evaluation of headache and regional cerebral flood flow in patients with migraine. (24089063)
2013
9
Age-related prevalence and features of migraine headache in Hungarian schoolchildren and adolescents. (23746927)
2013
10
The relationship between serum levels of vitamin D and migraine. (23961291)
2013
11
Migraine misdiagnosis as a sinusitis, a delay that can last for many years. (24330723)
2013
12
White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study. (23447382)
2013
13
Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke? (22404149)
2012
14
Does the neurobiology of migraine make migraine patients "difficult"? (24137827)
2012
15
Migraine: Role of the TRESK two-pore potassium channel. (21855646)
2011
16
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
17
Needle-free subcutaneous sumatriptan: in the acute treatment of migraine attacks or cluster headache episodes. (22054121)
2011
18
Migraine and restless legs syndrome: is there an association? (21660429)
2011
19
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). (21252164)
2011
20
Turn down the lights!: an irritable occipital cortex in migraine without aura. (21148117)
2011
21
Sumatriptan-naproxen fixed combination for acute treatment of migraine: a critical appraisal. (20368903)
2010
22
5-HTTLPR polymorphism in the serotonin transporter gene and migraine: a systematic review and meta-analysis. (20959425)
2010
23
No direct association of serotonin transporter (STin2 VNTR) and receptor (HT 102T>C) gene variants in genetic susceptibility to migraine. (21206007)
2010
24
Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. (20035431)
2010
25
Prolonged left homonymous hemianopsia associated with migraine-like attacks in a child with Sturge-Weber syndrome. (19800749)
2010
26
No association of migraine to the GABA-A receptor complex on chromosome 15. (17580321)
2008
27
Amino acid changes in the amino terminus of the Na,K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine. (17877748)
2007
28
Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3. (18021921)
2007
29
The influence of estrogen on migraine: a systematic review. (16622144)
2006
30
Serotonin transporter protein polymorphism and harm avoidance personality in migraine without aura. (16732845)
2006
31
Migraine-like attacks in child with Sturge-Weber syndrome without facial nevus. (15664776)
2005
32
A thromboembolic predisposition and the effect of anticoagulants on migraine. (15147246)
2004
33
Innovative treatment of acute migraine pain with CGRP receptor antagonists]. (15523578)
2004
34
Chemokine levels in the jugular venous blood of migraine without aura patients during attacks. (15546258)
2004
35
Migraine, cortical blindness, multiple cerebral infarctions and hypocoagulopathy in celiac disease. (12827546)
2003
36
Migraine with aura after intracranial endovascular procedures. (11318889)
2001
37
Triptans in the treatment of basilar migraine and migraine with prolonged aura. (11903526)
2001
38
Migrainous brain stem disturbance in Norrie disease: case report. (11430297)
2001
39
T-cell subsets and expression of integrins in peripheral blood of patients with migraine. (10570725)
1999
40
Transient global amnesia and migraine. A case control study. (9693225)
1998
41
Mitochondrial DNA in stroke and migraine with aura. (9548008)
1998
42
Familial hemiplegic migraine: involvement of a calcium neuronal channel. (9436352)
1997
43
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. (8967979)
1996
44
Common heredity of familial hemiplegic migraine and basilar artery migraine? (8706104)
1995
45
Migraine with aura as the presentation of leukemia. (8530284)
1995
46
The relationship between cyclic vomiting syndrome and abdominal migraine. (8708867)
1995
47
Sweating and vascular responses in the face: normal regulation and dysfunction in migraine, cluster headache and harlequin syndrome. (7888747)
1994
48
High incidence of endogenous depression in migraine: confirmation by tyramine test. (2391520)
1990
49
What is new in the treatment of migraine?]. (2155472)
1990
50
Capgras syndrome in a patient with migraine. (2289104)
1990

Genetic Variations for Migraine

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Expression for genes affiliated with Migraine

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine

Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

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29KEGG
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Pathways related to Migraine according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9DRD2, SCN1A, HTR3D, HTR1B, CACNA1A

Compounds for genes affiliated with Migraine

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Migraine according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1potassium44 11 2413.3ATP1A2, EDNRA, SCN1A, CACNA1A, KCNK18
2acetylcholine44 49 28 11 2415.1CALCA, CACNA1A, DRD2, EDNRA
3tetrodotoxin44 59 2813.1CALCA, SCN1A, EDNRA
4triptan4411.0CALCA, HTR1B
5rizatriptan44 28 1113.0HTR1B, CALCA
6teriparatide44 1112.0ESR1, CALCA
7ibandronate44 1111.9ESR1, CALCA
8roxindole28 4411.9HTR1B, DRD2
9terguride28 4411.9DRD2, HTR1B
10ritanserin28 4411.9DRD2, HTR1B
11sertindole28 44 1112.9DRD2, HTR1B
12ropinirole44 1111.8HTR1B, DRD2
13risedronate44 59 49 28 1114.8CALCA, ESR1
14maoa4410.8HTR1B, DRD2
15lisuride28 44 1112.7DRD2, HTR1B
16ergotamine28 44 1112.7HTR1B, DRD2
17ketanserin28 4411.7DRD2, HTR1B
18pergolide28 44 1112.6HTR1B, DRD2
19pramipexole44 49 28 1113.4DRD2, HTR1B

GO Terms for genes affiliated with Migraine

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16Gene Ontology
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Cellular components related to Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T-tubuleGO:03031510.8ATP1A2, EDNRA, SCN1A

Biological processes related to Migraine according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720411.1CALCA, CACNA1A, EDNRA, ESR1
2G-protein coupled receptor internalizationGO:00203111.0DRD2, HTR1B, CALCA
3elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148211.0EDNRA, DRD2, CALCA
4adult walking behaviorGO:00762811.0DRD2, SCN1A, CACNA1A
5regulation of blood pressureGO:00821711.0ATP1A2, EDNRA, CALCA
6neurological system process involved in regulation of systemic arterial blood pressureGO:00197610.9CALCA, DRD2
7reduction of cytosolic calcium ion concentrationGO:05148110.9DRD2, ATP1A2
8negative regulation of synaptic transmission, glutamatergicGO:05196710.8DRD2, HTR1B
9regulation of dopamine secretionGO:01405910.8DRD2, HTR1B
10negative regulation of cAMP biosynthetic processGO:03081810.8EDNRA, HTR1B
11vasoconstrictionGO:04231010.7HTR1B, EDNRA
12activation of protein kinase activityGO:03214710.7DRD2, CALCA
13response to nicotineGO:03509410.7ATP1A2, DRD2
14response to cocaineGO:04222010.6DRD2, HTR1B
15response to morphineGO:04327810.4EDNRA, DRD2

Products for genes affiliated with Migraine

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Sources for Migraine

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet