MCID: MGR002
MIFTS: 69

Migraine malady

Neuronal diseases category
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Summaries for Migraine

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Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

MalaCards: Migraine, also known as migraine disorder, is related to hemiplegic migraine and migraine without aura. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways are Synaptic transmission ion currents and Endothelin. The compounds triptan and teriparatide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:8 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus:34 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

Wikipedia:65 Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches... more...

Description from OMIM:47 157300

Aliases & Classifications for Migraine

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Sources:
8Disease Ontology, 22GTR, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

migraine 8 44 47 10 45 34
migraine disorder 8 22
migraine variant 8 62
migraine disorders 62


Related Diseases for Migraine

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Symptoms for Migraine

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

157300

Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Genetic Tests for Migraine

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Sources:
22GTR
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Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine22

Anatomical Context for Migraine

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Sources:
33MalaCards
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MalaCards organs/tissues related to Migraine:

33
Brain, Endothelial, Cortex, Testes, Heart, Liver, Thalamus, Pituitary, Monocytes, Trigeminal ganglion, Pineal, Tongue, Amygdala, Hypothalamus, Cerebellum, Occipital lobe, Smooth muscle, Kidney, T cells

Animal Models for Migraine or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Migraine:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5ESR1, EDNRA, ATP1A2, CACNA1A, CALCA, NOTCH3
2MP:00053699.5NOTCH3, EDNRA, ATP1A2, ESR1, HTR1B, CACNA1A
3MP:00053869.3NOTCH3, ATP1A2, SCN1A, ESR1, HTR1B, CACNA1A
4MP:00028739.2ATP1A2, NOTCH3, CALCA, CACNA1A, SCN1A, EDNRA
5MP:00036319.0CALCA, CACNA1A, ESR1, SCN1A, KCNK18, ATP1A2

Publications for Migraine

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52PubMed
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Articles related to Migraine:

(show top 50)    (show all 2088)
idTitleAuthorsYear
1
Nutraceuticals for the prevention of migraine in children: Do we know what the benefits and the risks are? (24436462)
2014
2
Is migraine a disorder of the central nervous system? (23695042)
2013
3
Genetic variants in the NOTCH4 gene influence the clinical features of migraine. (23566281)
2013
4
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
5
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? (24068339)
2013
6
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
7
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
8
Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. (23797675)
2013
9
Disrupted default mode network connectivity in migraine without aura. (24207164)
2013
10
Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura. (24038870)
2013
11
Regional homogeneity abnormalities affected by depressive symptoms in migraine patients without aura: a resting state study. (24147100)
2013
12
Serum iron may not be linked with migraine. (24101855)
2013
13
Association analysis of STX1A gene variants in common forms of migraine. (22250207)
2012
14
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
15
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
16
Migraine: Role of the TRESK two-pore potassium channel. (21855646)
2011
17
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
18
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
19
Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. (19673915)
2010
20
Migraine may be a risk factor for the development of complex regional pain syndrome. (19614690)
2010
21
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
22
The mechanism of peripheral and central sensitization in migraine. A literature review]. (19731814)
2009
23
Lack of association of hormone receptor polymorphisms with migraine. (19175383)
2009
24
Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. (19911463)
2009
25
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
26
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
27
Persistence with migraine prophylactic treatment and acute migraine medication utilization in the managed care setting. (19167603)
2008
28
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
29
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
30
Childhood steroid-responsive painful ophthalmoplegia: clues to ophthalmoplegic migraine. (17643751)
2007
31
Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. (17927652)
2007
32
Hemifacial spasm induced by trigeminal stimuli and coupled with ipsilateral migraine: a spasmodic migraine. (16919068)
2006
33
Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. (16472331)
2006
34
Acute aseptic meningitis inducing migraine-like attacks in a 7-year-old child. (16722988)
2006
35
Calcitonin gene-related peptide (CGRP) and migraine. (16927957)
2006
36
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
37
CGRP and migraine: neurogenic inflammation revisited. (16362644)
2005
38
No mutations in CACNA1A and ATP1A2 in probands with common types of migraine. (15210532)
2004
39
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
40
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
41
A typical migraine susceptibility region localizes to chromosome 1q31. (12030327)
2002
42
CGRP may play a causative role in migraine. (11993614)
2002
43
Development of CGRP antagonists for the treatment of migraine. (11717813)
2001
44
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
45
Chiropractic management of migraine without aura. A case study. (17987195)
1999
46
Role of magnesium in the pathogenesis and treatment of migraines. (9523054)
1998
47
Searching for migraine genes: exclusion of 290 cM out of the whole human genome. (9412851)
1997
48
Acute confusional migraine: variant of transient global amnesia. (7779209)
1995
49
Lack of association between anticardiolipin antibodies and migraine in systemic lupus erythematosus. (1549239)
1992
50
Migraine and anticardiolipin antibodies--case reports of 13 patients, and the prevalence of antiphospholipid antibodies in migraineurs. (1960059)
1991

Variations for Migraine

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Expression for genes affiliated with Migraine

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine

Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

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50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Migraine

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Migraine according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1triptan4510.4HTR1B, CALCA
2teriparatide45 1111.4CALCA, ESR1
3rizatriptan45 29 1112.3HTR1B, CALCA
4ibandronate45 1111.3CALCA, ESR1
5risedronate45 51 29 61 1114.3CALCA, ESR1
6n(g)-nitro-l-arginine methyl ester4510.3CALCA, EDNRA
7tetrodotoxin45 61 2912.2CALCA, SCN1A, EDNRA
8tibolone4510.2CALCA, ESR1
9sumatriptan45 29 61 51 24 1115.1CALCA, HTR1B
10phosphoramidon45 1111.0EDNRA, CALCA
11sodium45 2411.0EDNRA, ATP1A2, SCN1A, CACNA1A
12potassium45 24 1112.0CACNA1A, SCN1A, KCNK18, ATP1A2, EDNRA
13alendronate45 51 1111.8CALCA, ESR1
14testosterone45 61 24 1112.8CALCA, HTR1B, ESR1, EDNRA

GO Terms for genes affiliated with Migraine

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16Gene Ontology
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Cellular components related to Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.0CALCA, CACNA1A, SCN1A
2T-tubuleGO:0303159.9EDNRA, ATP1A2, SCN1A
3plasma membraneGO:0058868.5NOTCH3, EDNRA, ATP1A2, KCNK18, ESR1, PRRT2

Biological processes related to Migraine according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cAMP biosynthetic processGO:03081810.3EDNRA, HTR1B
2neuromuscular process controlling postureGO:05088410.3PRRT2, SCN1A
3G-protein coupled receptor internalizationGO:00203110.2HTR1B, CALCA
4positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.2CALCA, EDNRA
5regulation of blood pressureGO:00821710.2EDNRA, ATP1A2, CALCA
6adult walking behaviorGO:00762810.2CACNA1A, SCN1A
7vasoconstrictionGO:04231010.2HTR1B, EDNRA
8positive regulation of cytosolic calcium ion concentrationGO:00720410.1CALCA, CACNA1A, ESR1, EDNRA
9activation of adenylate cyclase activityGO:00719010.0EDNRA, CALCA
10protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.9HTR1B, EDNRA

Products for genes affiliated with Migraine

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Sources for Migraine

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet