MCID: MGR002
MIFTS: 71

Migraine malady

Neuronal diseases category

Summaries for Migraine

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

MalaCards: Migraine, also known as migraine disorder, is related to migraine without aura and familial hemiplegic migraine. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways is Circadian entrainment. The compounds potassium and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related mouse phenotypes are nervous system and respiratory system.

Disease Ontology:8 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus:33 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

Wikipedia:63 Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches... more...

Description from OMIM:46 157300

Aliases & Classifications for Migraine

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Sources:
8Disease Ontology, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

migraine 8 43 46 10 44 33
migraine disorder 8 22
migraine variant 8 60
migraine disorders 60


Related Diseases for Migraine

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Migraine family:

Migraine 8

Diseases related to Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1migraine without aura31.4ATP1A2, CACNA1A
2familial hemiplegic migraine31.4ATP1A2, SCN1A, CACNA1A, NOTCH3
3hemiplegic migraine30.4CACNA1A, SCN1A, ATP1A2
4hypertension30.4EDNRA, CALCA
5alternating hemiplegia of childhood30.3ATP1A2
6hemiplegia30.2CACNA1A, ATP1A2
7ischemia30.1EDNRA, DRD2, ATP1A2
8personality disorder29.8DRD2, HTR1B
9bipolar disorder29.8DRD2
10cluster headache29.6CALCA, CACNA1A
11obsessive-compulsive disorder29.6DRD2, HTR1B
12paraganglioma29.6CALCA
13migraine with aura11.1
14cerebritis10.6
15patent foramen ovale10.6
16familial hemiplegic migraine type 110.4
17cadasil10.4
18transient global amnesia10.4
19familial hemiplegic migraine type 210.4
20familial hemiplegic migraine type 310.4
21basilar migraine10.4
22neuronitis10.4
23episodic ataxia10.3
24motion sickness10.3
25sporadic hemiplegic migraine10.3
26restless legs syndrome10.3
27retinitis10.3
28scotoma10.2
29meniere's disease10.2
30meningitis10.2
31stroke, ischemic10.2
32arteriovenous malformation10.2
33obesity10.2
34vestibular disease10.2
35cerebellar ataxia10.1
36cervicitis10.1
37glaucoma10.1
38ophthalmoplegia10.1
39episodic ataxia type 210.1
40tolosa-hunt syndrome10.1
41intracranial hypertension10.1
42mitral valve prolapse10.0
43low tension glaucoma10.0
44carotid artery dissection10.0
45post-traumatic stress disorder10.0
46cerebrovascular disease10.0
47complex regional pain syndrome10.0
48epilepsy syndrome10.0
49multiple sclerosis10.0
50neuropathy10.0

Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Clinical Features for Migraine

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Sources:
46OMIM
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Clinical features from OMIM:

157300

Clinical synopsis from OMIM:

157300

Drugs & Therapeutics for Migraine

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Migraine

Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Search CenterWatch for Migraine

Genetic Tests for Migraine

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Sources:
22GTR
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Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine22

Anatomical Context for Migraine

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Sources:
32MalaCards
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MalaCards organs/tissues related to Migraine:

32
Brain, Endothelial, Cortex, Testes, Heart, Liver, Thalamus, Pituitary, Monocytes, Trigeminal ganglion, Pineal, Tongue, Amygdala, Hypothalamus, Cerebellum, Occipital lobe, Smooth muscle, Kidney, T cells

Animal Models for Migraine or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Migraine:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3CALCA, CACNA1A, SCN1A, DRD2, EDNRA, ATP1A2
2MP:000538811.0ESR1, CALCA, CACNA1A, DRD2, EDNRA, ATP1A2
3MP:000536910.8CACNA1A, HTR1B, DRD2, EDNRA, ATP1A2, NOTCH3

Publications for Migraine

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Sources:
50PubMed
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Articles related to Migraine:

(show top 50)    (show all 2109)
idTitleAuthorsYear
1
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
2
Low fetuin-A level in migraine: a case-control study. (23925572)
2014
3
Regional homogeneity abnormalities affected by depressive symptoms in migraine patients without aura: a resting state study. (24147100)
2013
4
Patent Foramen Ovale and Migraine Attacks: A Systematic Review. (24355354)
2013
5
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. (24347803)
2013
6
Latin American consensus on guidelines for chronic migraine treatment. (23857614)
2013
7
Agreement of self-reported physician diagnosis of migraine with international classification of headache disorders-II migraine diagnostic criteria in a cross-sectional study of pregnant women. (24330724)
2013
8
IgG-based elimination diet in migraine plus irritable bowel syndrome. (23216231)
2013
9
Brief migraine episodes in children and adolescents-a modification to International Headache Society pediatric migraine (without aura) diagnostic criteria. (23526480)
2013
10
Maternal personality profile of children affected by migraine. (24049447)
2013
11
Atenolol in the prophylaxis of chronic migraine: a 3-month open-label study. (24083117)
2013
12
Acute confusional migraine and transient global amnesia: variants of cognitive migraine? (24073981)
2013
13
Migraine genetics--a review: Part I. (23848970)
2013
14
Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I. (23532548)
2013
15
Quantification of macular carotenoids using autofluorescence imaging in patients with photosensitive migraine and benign essential blepharospasm. (22332230)
2012
16
Migraine-triggered hemifacial spasm: three new cases. (22421902)
2012
17
Irritable bowel syndrome associated with mitral valve prolapse and autonomic and haemostatic abnormalities in children, adolescents and adults with migraine. (21426307)
2011
18
Comorbidities in cluster headache and migraine. (21510234)
2011
19
Letter by Bhindi and Ormerod regarding article, "Lack of association between migraine headache and patent foramen ovale: results of a case-control study". (21156652)
2010
20
Indications and outcomes for surgical treatment of patients with chronic migraine headaches caused by occipital neuralgia. (19407615)
2009
21
Herbs for calming liver and suppressing liver-yang in treatment of migraine with hyperactive liver-yang syndrome and its effects on lymphocyte protein expression: a randomized controlled trial]. (19134454)
2009
22
Serum concentrations of s100b and NSE in migraine. (18783450)
2009
23
Familial clustering of migraine, episodic vertigo, and MAcniA"re's disease. (18046258)
2008
24
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
25
Genetics of migraine: an update with special attention to genetic comorbidity. (18451712)
2008
26
Topiramate-associated worsening symptoms in a patient with familial hemiplegic migraine. (18603263)
2008
27
Treatment of hemiplegic migraine with triptans. (17718700)
2007
28
Sporadic and familial hemiplegic migraine: diagnosis and treatment. (16628531)
2006
29
CGRP and migraine: neurogenic inflammation revisited. (16362644)
2005
30
Migraine genetics: an update. (15907261)
2005
31
A single-fibre EMG study of neuromuscular transmission in migraine patients. (16162259)
2005
32
Genetic aspects of migraine]. (14600747)
2003
33
NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. (14659530)
2003
34
Second gene identified for familial hemiplegic migraine. (12849225)
2003
35
Significance of serotonin transporter gene polymorphism in migraine. (11412868)
2001
36
No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine. (11424980)
2001
37
Immunological aspects in migraine: increase of IL-10 plasma levels during attack. (11576199)
2001
38
New methods for evaluating acute treatments in migraine. (11200791)
2000
39
Possible risk factors and precipitants for migraine with aura in discordant twin-pairs: a population-based study. (11167911)
2000
40
Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance. (10940095)
2000
41
CACNA1A mutations: hemiplegic migraine, episodic ataxia type 2, and the others. (10408526)
1999
42
Role of magnesium in the pathogenesis and treatment of migraines. (9523054)
1998
43
Increased cerebrovascular pCO2 reactivity in migraine with aura--a transcranial Doppler study during hyperventilation. (7553811)
1995
44
Achromatopsia in the aura of migraine. (8509791)
1993
45
Dopamine D2-receptor imaging with 123I-iodobenzamide SPECT in migraine patients abusing ergotamine: does ergotamine cross the blood brain barrier? (8242725)
1993
46
SUMATRIPTAN: a receptor-targeted treatment for migraine. (8386498)
1993
47
Extracranial blood flow, pain and tenderness in migraine. Clinical and experimental studies. (7694438)
1993
48
Suboccipital cerebrospinal fluid and plasma concentrations of somatostatin, neuropeptide Y and beta-endorphin in patients with common migraine. (1357579)
1992
49
Hemiplegic migraine. (7288457)
1981
50
Basilar migraine, seizures, and severe epileptiform EEG abnormalities. (565890)
1978

Genetic Variations for Migraine

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Expression for genes affiliated with Migraine

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine

Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

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29KEGG
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Pathways related to Migraine according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9DRD2, SCN1A, HTR3D, HTR1B, CACNA1A

Compounds for genes affiliated with Migraine

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Migraine according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1potassium44 11 2413.3ATP1A2, EDNRA, SCN1A, CACNA1A, KCNK18
2acetylcholine44 49 28 11 2415.1CALCA, CACNA1A, DRD2, EDNRA
3tetrodotoxin44 59 2813.1CALCA, SCN1A, EDNRA
4triptan4411.0CALCA, HTR1B
5rizatriptan44 28 1113.0HTR1B, CALCA
6teriparatide44 1112.0ESR1, CALCA
7ibandronate44 1111.9ESR1, CALCA
8roxindole28 4411.9HTR1B, DRD2
9terguride28 4411.9DRD2, HTR1B
10ritanserin28 4411.9DRD2, HTR1B
11sertindole28 44 1112.9DRD2, HTR1B
12ropinirole44 1111.8HTR1B, DRD2
13risedronate44 59 49 28 1114.8CALCA, ESR1
14maoa4410.8HTR1B, DRD2
15lisuride28 44 1112.7DRD2, HTR1B
16ergotamine28 44 1112.7HTR1B, DRD2
17ketanserin28 4411.7DRD2, HTR1B
18pergolide28 44 1112.6HTR1B, DRD2
19pramipexole44 49 28 1113.4DRD2, HTR1B

GO Terms for genes affiliated with Migraine

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16Gene Ontology
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Cellular components related to Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T-tubuleGO:03031510.8ATP1A2, EDNRA, SCN1A

Biological processes related to Migraine according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720411.1CALCA, CACNA1A, EDNRA, ESR1
2G-protein coupled receptor internalizationGO:00203111.0DRD2, HTR1B, CALCA
3elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148211.0EDNRA, DRD2, CALCA
4adult walking behaviorGO:00762811.0DRD2, SCN1A, CACNA1A
5regulation of blood pressureGO:00821711.0ATP1A2, EDNRA, CALCA
6neurological system process involved in regulation of systemic arterial blood pressureGO:00197610.9CALCA, DRD2
7reduction of cytosolic calcium ion concentrationGO:05148110.9DRD2, ATP1A2
8negative regulation of synaptic transmission, glutamatergicGO:05196710.8DRD2, HTR1B
9regulation of dopamine secretionGO:01405910.8DRD2, HTR1B
10negative regulation of cAMP biosynthetic processGO:03081810.8EDNRA, HTR1B
11vasoconstrictionGO:04231010.7HTR1B, EDNRA
12activation of protein kinase activityGO:03214710.7DRD2, CALCA
13response to nicotineGO:03509410.7ATP1A2, DRD2
14response to cocaineGO:04222010.6DRD2, HTR1B
15response to morphineGO:04327810.4EDNRA, DRD2

Products for genes affiliated with Migraine

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  • Antibodies
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Sources for Migraine

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet