MCID: MGR002
MIFTS: 61

Migraine malady

Neuronal category

Summaries for Migraine

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.

MalaCards: Migraine, also known as migraine disorder, is related to hemiplegic migraine and familial hemiplegic migraine. An important gene associated with Migraine is EDNRA (endothelin receptor type A), and among its related pathways is Circadian entrainment. The compounds potassium and acetylcholine have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and respiratory system.

Disease Ontology:8 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus:34 If you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

Wikipedia:64 Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches... more...

Description from OMIM:47 157300

Aliases & Classifications for Migraine

Sources:
8Disease Ontology, 22GTR, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

migraine 8 44 47 10 45 34
migraine disorder 8 22
migraine variant 8 61
migraine disorders 61


Related Diseases for Migraine

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Migraine family:

migraine without aura migraine with aura
migraine with or without aura 1 migraine 8
migraine with or without aura 3 migraine, with or without aura 12
migraine, with or without aura 13 migraine with aura 9
migraine without aura 4 migraine with aura 7
migraine with or without aura 5

Diseases related to Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1hemiplegic migraine31.6ATP1A2, SCN1A, CACNA1A
2familial hemiplegic migraine31.4CACNA1A, SCN1A, ATP1A2, NOTCH3
3cluster headache30.8CACNA1A, CALCA
4migraine without aura30.4ATP1A2, CACNA1A
5alternating hemiplegia of childhood30.0ATP1A2
6bipolar disorder29.8DRD2
7obsessive-compulsive disorder29.6DRD2, HTR1B
8paraganglioma29.6CALCA
9headache10.9
10basilar migraine10.7
11patent foramen ovale10.6
12ataxia10.4
13cadasil10.4
14familial hemiplegic migraine type 110.4
15transient global amnesia10.4
16familial hemiplegic migraine type 210.4
17familial hemiplegic migraine type 310.4
18cyclic vomiting syndrome10.4
19episodic ataxia10.4
20restless legs syndrome10.3
21scotoma10.3
22n syndrome10.3
23sturge-weber syndrome10.2
24weber syndrome10.2
25stroke, ischemic10.2
26arteriovenous malformation10.2
27vestibular disease10.2
28migraine, familial basilar10.2
29fibromyalgia10.2
30occipital neuralgia10.2
31migraine 810.2
32tolosa-hunt syndrome10.1
33hemicrania continua10.1
34hemifacial spasm10.1
35syncope10.1
36paroxysmal dyskinesia10.1
37mitral valve prolapse10.1
38carotid artery dissection10.1
39post-traumatic stress disorder10.1
40sleep disorder10.1
41vasculitis10.1
42paroxysmal hemicrania10.1
43blindness10.1
44moyamoya disease10.0
45neurofibromatosis10.0
46sensorineural hearing loss10.0
47melas syndrome10.0
48ischemic neuropathy10.0
49panic disorder10.0
50dyspepsia10.0

Graphical network of the top 20 diseases related to Migraine:



Diseases related to migraine

Clinical Features for Migraine

Sources:
47OMIM
See all sources

Clinical features from OMIM:

157300

Clinical synopsis from OMIM:

157300

Drugs & Therapeutics for Migraine

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Migraine

Drug clinical trials:

Search ClinicalTrials for Migraine

Search NIH Clinical Center for Migraine

Search CenterWatch for Migraine

Genetic Tests for Migraine

Sources:
22GTR
See all sources

Genetic tests related to Migraine:

id Genetic test Affiliating Genes
1 Migraine22

Anatomical Context for Migraine

Animal Models for Migraine or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Migraine:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3NOTCH3, ATP1A2, EDNRA, DRD2, SCN1A, CACNA1A
2MP:000538811.0CALCA, ESR1, NOTCH3, ATP1A2, EDNRA, DRD2
3MP:000536910.8CACNA1A, HTR1B, DRD2, EDNRA, ATP1A2, NOTCH3

Publications for Migraine

Sources:
51PubMed
See all sources

Articles related to Migraine:

(show top 50)    (show all 2111)
idTitleAuthorsYear
1
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
2
Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study. (24412801)
2014
3
Genetic variants in the NOTCH4 gene influence the clinical features of migraine. (23566281)
2013
4
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study. (24275145)
2013
5
Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy. (23838748)
2013
6
Lifetime Prevalence and Correlates of Migraine Among Women in a Pacific Northwest Pregnancy Cohort Study. (23992560)
2013
7
Migraine headache triggered specifically by sunlight: report of 16 cases. (24051692)
2013
8
Episodic migraine and obesity and the influence of age, race, and sex. (24027060)
2013
9
"Compulsive plague! pain without end!" How Richard Wagner played out his migraine in the opera Siegfried. (24336305)
2013
10
Self-directed Mindfulness Training and Improvement in Blood Pressure, Migraine Frequency, and Quality of Life. (24278842)
2013
11
Association of MTHFR C677T polymorphism with susceptibility to migraine in the Chinese population. (23811028)
2013
12
Pediatric hemiplegic migraine: Role of multiple MRI techniques in evaluation of reversible hypoperfusion. (24142848)
2013
13
Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. (23126519)
2013
14
A prospective, open-label study of milnacipran in the prevention of headache in patients with episodic or chronic migraine. (24030685)
2013
15
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Propofol for migraine. (23872997)
2013
16
Migraine and white matter hyperintensities: the ARIC MRI study. (23975874)
2013
17
Evaluating the prophylaxis and long-term effectiveness of acupuncture for migraine without aura: study protocol for a randomized controlled trial. (24171782)
2013
18
Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Meniere's disease. (22259049)
2012
19
Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. (21539819)
2011
20
31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. (21289000)
2011
21
Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation. (21533737)
2011
22
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
23
Link between confusional migraine, hemiplegic migraine and episodic ataxia type 2: hypothesis, family genealogy, gene typing and classification. (19624685)
2010
24
Cerebral distribution of white matter lesions in migraine with aura patients. (20647177)
2010
25
Calcitonin gene-related peptide: A molecular link between obesity and migraine? (20369076)
2010
26
Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. (20206581)
2010
27
Migraine and patent foramen ovale: state of the science. (19951764)
2009
28
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. (19570717)
2009
29
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. (19336355)
2009
30
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
31
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
32
Delayed hyperperfusion following migraine with a prolonged aphasic aura in a patient with CADASIL. (18540869)
2008
33
Migraine secondary to superior oblique myokymia. (17692104)
2007
34
Effects of oestrogen on trigeminal ganglia in culture: implications for hormonal effects on migraine. (16396664)
2006
35
Clinical data on the CGRP antagonist BIBN4096BS for treatment of migraine attacks. (15867953)
2005
36
Monoamine oxidases A and B gene polymorphisms in migraine patients. (15694196)
2005
37
Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees. (16157018)
2005
38
Chromosome 19p13 loci in Finnish migraine with aura families. (15449251)
2005
39
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
40
Genetic aspects of migraine]. (14600747)
2003
41
Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. (11328331)
2001
42
Long term decline of P100 amplitude in migraine with aura. (10990512)
2000
43
A new family with paroxysmal exercise induced dystonia and migraine: a clinical and genetic study. (10766892)
2000
44
Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? (9876885)
1998
45
Preventive treatment of migraine and chronic tension headache with moclobemide]. (9324719)
1997
46
Autosomal dominant migraine with MRI white-matter abnormalities mapping to the CADASIL locus. (7783868)
1995
47
Migraine and anticardiolipin antibodies--case reports of 13 patients, and the prevalence of antiphospholipid antibodies in migraineurs. (1960059)
1991
48
Hemiplegic migraine and progressive hemifacial atrophy. (4026238)
1985
49
Hemiplegic migraine. (7288457)
1981
50
Hemiplegic migraine. (13489617)
1958

Genetic Variations for Migraine

Expression for genes affiliated with Migraine

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Migraine

Search GEO for disease gene expression data for Migraine.

Pathways for genes affiliated with Migraine

Sources:
30KEGG
See all sources

Pathways related to Migraine according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9DRD2, SCN1A, HTR3D, HTR1B, CACNA1A

Compounds for genes affiliated with Migraine

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Migraine according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1potassium45 11 2413.3ATP1A2, EDNRA, SCN1A, CACNA1A, KCNK18
2acetylcholine45 50 29 11 2415.1CALCA, CACNA1A, DRD2, EDNRA
3tetrodotoxin45 60 2913.1CALCA, SCN1A, EDNRA
4triptan4511.0CALCA, HTR1B
5rizatriptan45 29 1113.0HTR1B, CALCA
6teriparatide45 1112.0ESR1, CALCA
7ibandronate45 1111.9ESR1, CALCA
8roxindole29 4511.9HTR1B, DRD2
9terguride29 4511.9DRD2, HTR1B
10ritanserin29 4511.9DRD2, HTR1B
11sertindole29 45 1112.9DRD2, HTR1B
12ropinirole45 1111.8HTR1B, DRD2
13risedronate45 60 50 29 1114.8CALCA, ESR1
14maoa4510.8HTR1B, DRD2
15lisuride29 45 1112.7DRD2, HTR1B
16ergotamine29 45 1112.7HTR1B, DRD2
17ketanserin29 4511.7DRD2, HTR1B
18pergolide29 45 1112.6HTR1B, DRD2
19pramipexole45 50 29 1113.4DRD2, HTR1B

GO Terms for genes affiliated with Migraine

Sources:
16Gene Ontology
See all sources

Cellular components related to Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T-tubuleGO:03031510.8ATP1A2, EDNRA, SCN1A

Biological processes related to Migraine according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720411.1CALCA, CACNA1A, EDNRA, ESR1
2G-protein coupled receptor internalizationGO:00203111.0DRD2, HTR1B, CALCA
3elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148211.0EDNRA, DRD2, CALCA
4adult walking behaviorGO:00762811.0DRD2, SCN1A, CACNA1A
5regulation of blood pressureGO:00821711.0ATP1A2, EDNRA, CALCA
6neurological system process involved in regulation of systemic arterial blood pressureGO:00197610.9CALCA, DRD2
7reduction of cytosolic calcium ion concentrationGO:05148110.9DRD2, ATP1A2
8negative regulation of synaptic transmission, glutamatergicGO:05196710.8DRD2, HTR1B
9regulation of dopamine secretionGO:01405910.8DRD2, HTR1B
10negative regulation of cAMP biosynthetic processGO:03081810.8EDNRA, HTR1B
11vasoconstrictionGO:04231010.7HTR1B, EDNRA
12activation of protein kinase activityGO:03214710.7DRD2, CALCA
13response to nicotineGO:03509410.7ATP1A2, DRD2
14response to cocaineGO:04222010.6DRD2, HTR1B
15response to morphineGO:04327810.4EDNRA, DRD2

Products for genes affiliated with Migraine

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  • Lysates
  • Antibodies

Sources for Migraine

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet