MCID: MGR003
MIFTS: 38

Migraine with Aura malady

Summaries for Migraine with Aura

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64Wikipedia, 33MalaCards
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Wikipedia:64 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

MalaCards: Migraine with Aura, also known as migraine disorders, is related to hemiplegic migraine and restless legs syndrome. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Monoamine Transport and Synaptic vesicle cycle. The compounds cgs-12066 and sb 224289 have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and respiratory system.

Aliases & Classifications for Migraine with Aura

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

migraine with aura 8 10 61
migraine disorders 61
classic migraine 8


External Ids:

Disease Ontology8 DOID:10024
ICD9CM27 346.0
SNOMED-CT57 155047002, 4473006
MeSH35 D020325

Related Diseases for Migraine with Aura

Sources:
17GeneCards, 18GeneDecks
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Diseases in the migraine family:

migraine without aura migraine with aura
migraine with or without aura 1 migraine 8
migraine with or without aura 3 migraine, with or without aura 12
migraine, with or without aura 13 migraine with aura 9
migraine without aura 4 migraine with aura 7
migraine with or without aura 5

Diseases related to Migraine with Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1hemiplegic migraine30.7CACNA1A, ATP1A2
2restless legs syndrome30.6DRD2
3cluster headache30.5VIP, CACNA1A
4familial hemiplegic migraine30.5ATP1A2, CACNA1A
5cadasil30.5ADORA2A, VIP, MTHFR, NOTCH3, EDNRB
6asthma30.2ADORA2A, VIP
7headache10.8
8patent foramen ovale10.6
9arteriovenous malformation10.5
10stroke, ischemic10.3
11hemicrania continua10.3
12migraine with aura 910.3
13migraine with aura 710.3
14moyamoya disease10.2
15marfan syndrome10.2
16mitral valve prolapse10.2
17prosopagnosia10.2
18ischemic neuropathy10.2
19scotoma10.2
20fabry disease10.2
21ischemic optic neuropathy10.2
22acute myocardial infarction10.2
23vasculitis10.2
24epitheliopathy, acute posterior multifocal placoid pigment10.2
25pulmonary arteriovenous malformation10.2
26mthfr gene mutation10.2
27cardiovascular disease risk factor10.2
28head injury10.2
29syncope10.2
30migraine 810.2
31homocysteine plasma level10.2
32stroke, hemorrhagic10.2
33paroxysmal dyskinesia10.2
34cyclic vomiting syndrome10.0
35paroxysmal hemicrania10.0
36dementia10.0NOTCH3
37wilson disease10.0DRD2
38premature ejaculation10.0SLC6A4
39neuropathy10.0CACNA1A
40eating disorder10.0SLC6A4
41heroin dependence10.0DRD2
42borderline personality disorder10.0HTR1B, SLC6A4
43bulimia nervosa10.0HTR1B, SLC6A4
44anorexia nervosa10.0HTR2C, SLC6A4
45alternating hemiplegia of childhood10.0ATP1A2
46substance abuse10.0SLC6A4, DRD2
47multiple system atrophy10.0DBH, DRD2
48vascular dementia10.0NOTCH3
49constipation10.0SLC6A4, VIP
50migraine without aura10.0CACNA1A, ATP1A2

Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Clinical Features for Migraine with Aura

Drugs & Therapeutics for Migraine with Aura

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Migraine with Aura

Drug clinical trials:

Search ClinicalTrials for Migraine with Aura

Search NIH Clinical Center for Migraine with Aura

Search CenterWatch for Migraine with Aura

Genetic Tests for Migraine with Aura

Anatomical Context for Migraine with Aura

Animal Models for Migraine with Aura or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Migraine with Aura

Genetic Variations for Migraine with Aura

Expression for genes affiliated with Migraine with Aura

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

Sources:
38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 54Reactome
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Compounds for genes affiliated with Migraine with Aura

Sources:
29IUPHAR, 45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1cgs-120662910.4HTR1D, HTR1B, HTR2C
2sb 2242892910.4HTR2C, HTR1B, HTR1D
3ketanserin29 4511.4SLC6A4, DRD2, HTR1D, HTR1B
4s330842910.4HTR1B, HTR2C, HTR1D
5sb 2166412910.4HTR1B, HTR1D, HTR2C
6roxindole29 4511.3HTR2C, DRD2, HTR1D, HTR1B
7antipsychotics5010.3DRD2, HTR2C, MTHFR
8terguride29 4511.3DRD2, HTR1D, HTR2C, HTR1B
9ritanserin29 4511.3HTR2C, HTR1B, HTR1D, DRD2
10sertindole29 45 1112.3DRD2, HTR2C, HTR1D, HTR1B
11tfmpp2910.3HTR1B, HTR2C, HTR1D
12ropinirole45 1111.3HTR1B, HTR2C, DRD2, HTR1D
13lisuride29 45 1112.3HTR1D, DRD2, HTR2C, HTR1B
14pergolide29 45 1112.3HTR2C, DRD2, HTR1B, HTR1D
15ergotamine29 45 1112.3HTR2C, HTR1B, HTR1D, DRD2
16pramipexole45 50 29 1113.3HTR1D, HTR2C, HTR1B, DRD2
17maoa4510.3DBH, SLC6A4, HTR2C, HTR1B, DRD2
18asenapine29 1111.3HTR1D, HTR1B, DRD2, HTR2C
19cabergoline29 45 1112.3HTR1D, HTR2C, DRD2, HTR1B
20sl65.01552910.3HTR2C, HTR1D, HTR1B
21aripiprazole29 50 45 11 2414.3HTR2C, HTR1B, HTR1D, DRD2
22gr-1279352910.3HTR1D, HTR1B, HTR2C
23ziprasidone50 29 45 1113.2HTR2C, HTR1B, HTR1D, DRD2
24ly3448642910.2HTR2C, HTR1B, HTR1D
25levodopa45 1111.2ADORA2A, MTHFR, DBH, HTR1B, DRD2
26mcpp4510.2SLC6A4, HTR2C, HTR1B
27quetiapine45 50 29 11 2414.2HTR1B, DRD2, ADORA2A, HTR1D, HTR2C
28yohimbine45 29 2 1113.2HTR2C, HTR1B, HTR1D, DRD2
29brl-155722910.2HTR1B, HTR2C, HTR1D
30apomorphine45 29 1112.2DRD2, HTR1D, HTR2C, HTR1B
31bromocriptine29 45 1112.2VIP, HTR2C, HTR1B, DRD2, HTR1D
32risperidone29 45 50 60 11 2415.2HTR1D, HTR1B, DRD2, HTR2C, SLC6A4
33propranolol45 29 50 11 2414.2DBH, HTR1D, HTR1B, HTR2C, VIP
34ru 2496929 4511.2HTR1D, HTR1B, HTR2C
35cocaine45 1111.1HTR1B, SLC6A4, ADORA2A, DBH, HTR2C, DRD2
36haloperidol45 29 2 50 1114.1VIP, HTR1D, SLC6A4, ADORA2A, DRD2
375-meot2910.1HTR1D, HTR1B, HTR2C
38amine4510.1HTR2C, ADORA2A, HTR1D, DBH, HTR1B, SLC6A4
39clozapine45 29 50 1113.1ADORA2A, SLC6A4, HTR1B, DRD2, HTR1D, HTR2C
40ipsapirone45 2911.0HTR2C, HTR1B, HTR1D
41acetylcholine45 50 29 11 2414.0EDNRB, HTR2C, DRD2, VIP, DBH, ADORA2A
42fluoxetine50 45 29 1113.0SLC6A4, DRD2, HTR1B, HTR2C
43gaba459.9ADORA2A, VIP, HTR2C, GABRA5, DBH, SLC6A4
44oxymetazoline29 45 1111.9HTR2C, HTR1B, HTR1D
45norepinephrine45 11 2411.8EDNRB, DBH, HTR1D, ADORA2A, HTR2C, DRD2
46adenylate459.8ADORA2A, DBH, EDNRB, DRD2, HTR1D, HTR2C
475-carboxamidotryptamine459.7HTR2C, HTR1D, HTR1B
485-hydroxytryptamine459.7DRD2, ADORA2A, SLC6A4, DBH, VIP, HTR2C
49dopamine45 29 11 2412.7VIP, HTR1B, HTR1D, DRD2, MTHFR, DBH
50glutamate459.6DBH, ADORA2A, MTHFR, EDNRB, VIP, SLC6A4

GO Terms for genes affiliated with Migraine with Aura

Sources:
16Gene Ontology
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Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.9ADORA2A, GABRA5, DRD2, CACNA1A
2integral to plasma membraneGO:0058879.1ADORA2A, SLC6A4, EDNRB, GABRA5, DRD2, HTR1D
3plasma membraneGO:0058868.6ADORA2A, KCNK18, CACNA1A, NOTCH3, SLC6A4, ATP1A2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.5ATP1A2, DRD2
2positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5ADORA2A, VIP
3behavioral response to ethanolGO:04814910.5DBH, DRD2
4negative regulation of synaptic transmission, glutamatergicGO:05196710.5DRD2, HTR1B
5regulation of dopamine secretionGO:01405910.5HTR1B, DRD2
6positive regulation of urine volumeGO:03581010.4ADORA2A, EDNRB, DRD2
7G-protein coupled receptor internalizationGO:00203110.4HTR1B, DRD2
8visual learningGO:00854210.4DRD2, ATP1A2, DBH
9positive regulation of renal sodium excretionGO:03581510.4DRD2, EDNRB, ADORA2A
10response to amphetamineGO:00197510.4ADORA2A, DBH, DRD2
11synaptic transmission, dopaminergicGO:00196310.4DRD2, ADORA2A
12regulation of behaviorGO:05079510.4HTR1B, HTR1D
13prepulse inhibitionGO:06013410.3ADORA2A, DRD2
14response to toxic substanceGO:00963610.3HTR1D, DRD2, SLC6A4
15locomotory behaviorGO:00762610.3ADORA2A, DBH, DRD2, HTR2C
16vasoconstrictionGO:04231010.3SLC6A4, EDNRB, HTR1D, HTR1B
17elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, HTR2C
18response to painGO:04826510.2EDNRB, DBH
19regulation of sensory perception of painGO:05193010.2EDNRB, VIP
20response to drugGO:04249310.1HTR2C, DRD2, SLC6A4, ADORA2A
21associative learningGO:00830610.1GABRA5, DRD2
22vasodilationGO:0423119.9ADORA2A, EDNRB
23synaptic transmissionGO:0072689.8KCNK18, CACNA1A, HTR2C, HTR1B, HTR1D, GABRA5

Molecular functions related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.1DRD2, HTR1B, HTR2C
2serotonin bindingGO:0513789.9HTR1D, HTR1B, HTR2C
3serotonin receptor activityGO:0049939.7HTR1D, HTR1B, HTR2C

Products for genes affiliated with Migraine with Aura

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Sources for Migraine with Aura

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet