MCID: MGR003
MIFTS: 53

Migraine with Aura malady

Summaries for Migraine with Aura

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63Wikipedia, 32MalaCards
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Wikipedia:63 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

MalaCards: Migraine with Aura, also known as migraine disorders, is related to migraine and migraine without aura. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Monoamine Transport and Synaptic vesicle cycle. The compounds cgs-12066 and sb 224289 have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and endothelial, and related mouse phenotypes are cardiovascular system and respiratory system.

Aliases & Classifications for Migraine with Aura

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

migraine with aura 8 10 60
migraine disorders 60
classic migraine 8


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Disease Ontology8 DOID:10024
ICD9CM27 346.0
SNOMED-CT56 155047002, 4473006
MeSH34 D020325

Related Diseases for Migraine with Aura

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17GeneCards, 18GeneDecks
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Diseases in the Migraine with Aura family:

Migraine with Aura 9 Migraine with Aura 7

Diseases related to Migraine with Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.1NOTCH3, VIP, KCNK18, CACNA1A, HTR2C, HTR1B
2migraine without aura31.3CACNA1A, ATP1A2
3restless legs syndrome30.6DRD2
4familial hemiplegic migraine30.5ATP1A2, CACNA1A
5cadasil30.4VIP, EDNRB, MTHFR, NOTCH3, ADORA2A
6neuropathy30.2CACNA1A
7hemiplegic migraine30.2CACNA1A, ATP1A2
8obesity30.2DRD2, HTR2C
9ischemia30.2VIP, DRD2, ATP1A2, ADORA2A
10asthma30.2VIP, ADORA2A
11hypertension30.2EDNRB, MTHFR, DBH, SLC6A4
12cerebritis10.7
13patent foramen ovale10.6
14arteriovenous malformation10.5
15stroke, ischemic10.3
16cervicitis10.3
17migraine with aura 910.3
18migraine with aura 710.3
19moyamoya disease10.2
20marfan syndrome10.2
21crohn's disease10.2
22mitral valve prolapse10.2
23prosopagnosia10.2
24arachnoiditis10.2
25ischemic neuropathy10.2
26scotoma10.2
27chronic tic disorder10.2
28fabry disease10.2
29ischemic optic neuropathy10.2
30acute myocardial infarction10.2
31cerebrovascular disease10.2
32leukemia10.2
33meningitis10.2
34myocardial infarction10.2
35tic disorder10.2
36vasculitis10.2
37familial hemiplegic migraine type 110.2
38retinal artery occlusion10.0
39retinitis10.0
40sporadic hemiplegic migraine10.0
41dementia10.0NOTCH3
42wilson disease10.0DRD2
43premature ejaculation10.0SLC6A4
44eating disorder10.0SLC6A4
45heroin dependence10.0DRD2
46borderline personality disorder10.0SLC6A4, HTR1B
47bulimia nervosa10.0HTR1B, SLC6A4
48cluster headache10.0CACNA1A, VIP
49anorexia nervosa10.0SLC6A4, HTR2C
50alternating hemiplegia of childhood10.0ATP1A2

Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Clinical Features for Migraine with Aura

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Drugs & Therapeutics for Migraine with Aura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Migraine with Aura

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Anatomical Context for Migraine with Aura

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32MalaCards
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MalaCards organs/tissues related to Migraine with Aura:

32
Cortex, Brain, Endothelial, Heart, Testes, Liver, Pituitary

Animal Models for Migraine with Aura or affiliated genes

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36MGI
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Publications for Migraine with Aura

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50PubMed
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Articles related to Migraine with Aura:

(show top 50)    (show all 368)
idTitleAuthorsYear
1
Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: A randomized study. (24363238)
2014
2
Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura. (24038870)
2013
3
White matter lesions progression in migraine with aura: a clinical and MRI longitudinal study. (22268442)
2013
4
Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. (23578775)
2013
5
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
6
The effect of patent foramen ovale closure on visual aura without headache or typical aura with migraine headache. (22721665)
2012
7
Cortical sensory plasticity in a model of migraine with aura. (23115163)
2012
8
Frovatriptan versus zolmitriptan for the acute treatment of migraine with aura: a subgroup analysis of a double-blind, randomized, multicenter, Italian study. (22644173)
2012
9
The borderland of migraine with aura: episodic unilateral mydriasis. (20862508)
2011
10
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). (21252164)
2011
11
Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study. (21816769)
2011
12
High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability? (19438928)
2010
13
Microembolic air load during contrast-transcranial Doppler: a trigger for migraine with aura? (20132338)
2010
14
Migraine: migraine with aura increases the risk of stroke. (20212428)
2010
15
Acute multifocal posterior placoid pigment epitheliopathy (AMPPPE) mimicking migraine with aura. (19220303)
2009
16
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. (19570717)
2009
17
Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. (17690944)
2008
18
Increased cerebral vasomotor reactivity in migraine with aura: an autoregulation disorder? A transcranial Doppler and near-infrared spectroscopy study. (18460006)
2008
19
Toward a further elucidation: role of vertebral artery hypoplasia in migraine with aura. (18057902)
2008
20
Abnormal visual processing in migraine with aura: a study of steady-state visual evoked potentials. (18495160)
2008
21
Co-occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure. (17572070)
2007
22
Migraine with aura and dental occlusion: a case report. (16536161)
2006
23
Current views of the risk of stroke for migraine with and migraine without aura. (18778576)
2006
24
Implications of clinical subtypes of migraine with aura. (16492238)
2006
25
Cessation of migraine with aura following removal of left atrial myxoma. (16930350)
2006
26
Disability pattern in chronic migraine with medication overuse: a comparison with migraine without aura. (15953274)
2005
27
Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura. (15644278)
2005
28
Migraine with aura from pathophysiology to treatment: therapeutic strategies. (15926005)
2005
29
A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes. (15586324)
2005
30
Hemicrania continua evolving from migraine with aura: clinical evidence of a possible correlation between two forms of primary headache. (15482368)
2004
31
Significant linkage to migraine with aura on chromosome 11q24. (12915447)
2003
32
Migraine with aura during pregnancy. (12864766)
2003
33
Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. (12390611)
2002
34
Migraine with aura after administration of sublingual nitroglycerin tablets. (11168608)
2001
35
Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine. (11489292)
2001
36
A prospective study of migraine with aura attacks in a headache clinic population. (11304028)
2000
37
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
38
Cerebral metastasis presenting as Valsalva-induced migraine with aura. (11279909)
1998
39
Clinical characteristics and long-term outcome of migraine with aura in children and adolescents. (9003726)
1997
40
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
41
A comparison of divalproex with propranolol and placebo for the prophylaxis of migraine without aura. (9311358)
1997
42
Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. (8536297)
1995
43
Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. (7641249)
1995
44
Immunocyte enumeration in duodenal biopsies of migraine without aura patients with or without food-induced migraine. (7828196)
1994
45
NMR spectroscopic and magnetoencephalographic studies in migraine with aura: support for the spreading depression hypothesis. (1495820)
1992
46
A double-blind controlled study of nifedipine as an abortive treatment in acute attacks of migraine with aura. (1423566)
1992
47
Sumatriptan in the treatment of acute migraine with aura. (1313746)
1992
48
In vivo administration of propranolol decreases exaggerated amounts of serum TNF-alpha in patients with migraine without aura. Possible mechanism of action. (1293974)
1992
49
Migraine with aura, cerebral ischemia, spreading depression, and compton scatter. (2016168)
1991
50
Alpha rhythm in classical migraine (migraine with aura): abnormalities in the headache-free interval. (2245466)
1990

Genetic Variations for Migraine with Aura

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Expression for genes affiliated with Migraine with Aura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

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37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Migraine with Aura

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1cgs-120662810.4HTR1D, HTR1B, HTR2C
2sb 2242892810.4HTR2C, HTR1B, HTR1D
3ketanserin28 4411.4SLC6A4, DRD2, HTR1D, HTR1B
4s330842810.4HTR1B, HTR2C, HTR1D
5sb 2166412810.4HTR1B, HTR1D, HTR2C
6roxindole28 4411.3HTR2C, DRD2, HTR1D, HTR1B
7antipsychotics4910.3DRD2, HTR2C, MTHFR
8terguride28 4411.3DRD2, HTR1D, HTR2C, HTR1B
9ritanserin28 4411.3HTR2C, HTR1B, HTR1D, DRD2
10sertindole28 44 1112.3DRD2, HTR2C, HTR1D, HTR1B
11tfmpp2810.3HTR1B, HTR2C, HTR1D
12ropinirole44 1111.3HTR1B, HTR2C, DRD2, HTR1D
13lisuride28 44 1112.3HTR1D, DRD2, HTR2C, HTR1B
14pergolide28 44 1112.3HTR2C, DRD2, HTR1B, HTR1D
15ergotamine28 44 1112.3HTR2C, HTR1B, HTR1D, DRD2
16pramipexole44 49 28 1113.3HTR1D, HTR2C, HTR1B, DRD2
17maoa4410.3DBH, SLC6A4, HTR2C, HTR1B, DRD2
18asenapine28 1111.3HTR1D, HTR1B, DRD2, HTR2C
19cabergoline28 44 1112.3HTR1D, HTR2C, DRD2, HTR1B
20sl65.01552810.3HTR2C, HTR1D, HTR1B
21aripiprazole28 49 44 11 2414.3HTR2C, HTR1B, HTR1D, DRD2
22gr-1279352810.3HTR1D, HTR1B, HTR2C
23ziprasidone49 28 44 1113.2HTR2C, HTR1B, HTR1D, DRD2
24ly3448642810.2HTR2C, HTR1B, HTR1D
25levodopa44 1111.2ADORA2A, MTHFR, DBH, HTR1B, DRD2
26mcpp4410.2SLC6A4, HTR2C, HTR1B
27quetiapine44 49 28 11 2414.2HTR1B, DRD2, ADORA2A, HTR1D, HTR2C
28yohimbine44 28 2 1113.2HTR2C, HTR1B, HTR1D, DRD2
29brl-155722810.2HTR1B, HTR2C, HTR1D
30apomorphine44 28 1112.2DRD2, HTR1D, HTR2C, HTR1B
31bromocriptine28 44 1112.2VIP, HTR2C, HTR1B, DRD2, HTR1D
32risperidone28 44 49 59 11 2415.2HTR1D, HTR1B, DRD2, HTR2C, SLC6A4
33propranolol44 28 49 11 2414.2DBH, HTR1D, HTR1B, HTR2C, VIP
34ru 2496928 4411.2HTR1D, HTR1B, HTR2C
35cocaine44 1111.1HTR1B, SLC6A4, ADORA2A, DBH, HTR2C, DRD2
36haloperidol44 28 2 49 1114.1VIP, HTR1D, SLC6A4, ADORA2A, DRD2
375-meot2810.1HTR1D, HTR1B, HTR2C
38amine4410.1HTR2C, ADORA2A, HTR1D, DBH, HTR1B, SLC6A4
39clozapine44 28 49 1113.1ADORA2A, SLC6A4, HTR1B, DRD2, HTR1D, HTR2C
40ipsapirone44 2811.0HTR2C, HTR1B, HTR1D
41acetylcholine44 49 28 11 2414.0EDNRB, HTR2C, DRD2, VIP, DBH, ADORA2A
42fluoxetine49 44 28 1113.0SLC6A4, DRD2, HTR1B, HTR2C
43gaba449.9ADORA2A, VIP, HTR2C, GABRA5, DBH, SLC6A4
44oxymetazoline28 44 1111.9HTR2C, HTR1B, HTR1D
45norepinephrine44 11 2411.8EDNRB, DBH, HTR1D, ADORA2A, HTR2C, DRD2
46adenylate449.8ADORA2A, DBH, EDNRB, DRD2, HTR1D, HTR2C
475-carboxamidotryptamine449.7HTR2C, HTR1D, HTR1B
485-hydroxytryptamine449.7DRD2, ADORA2A, SLC6A4, DBH, VIP, HTR2C
49dopamine44 28 11 2412.7VIP, HTR1B, HTR1D, DRD2, MTHFR, DBH
50glutamate449.6DBH, ADORA2A, MTHFR, EDNRB, VIP, SLC6A4

GO Terms for genes affiliated with Migraine with Aura

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16Gene Ontology
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Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.9ADORA2A, GABRA5, DRD2, CACNA1A
2integral to plasma membraneGO:0058879.1ADORA2A, KCNK18, HTR2C, HTR1B, HTR1D, DRD2
3plasma membraneGO:0058868.6HTR1D, HTR1B, HTR2C, CACNA1A, KCNK18, DRD2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.5ATP1A2, DRD2
2positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5ADORA2A, VIP
3behavioral response to ethanolGO:04814910.5DBH, DRD2
4negative regulation of synaptic transmission, glutamatergicGO:05196710.5DRD2, HTR1B
5regulation of dopamine secretionGO:01405910.5HTR1B, DRD2
6positive regulation of urine volumeGO:03581010.4ADORA2A, EDNRB, DRD2
7G-protein coupled receptor internalizationGO:00203110.4HTR1B, DRD2
8visual learningGO:00854210.4DRD2, ATP1A2, DBH
9positive regulation of renal sodium excretionGO:03581510.4DRD2, EDNRB, ADORA2A
10response to amphetamineGO:00197510.4ADORA2A, DBH, DRD2
11synaptic transmission, dopaminergicGO:00196310.4DRD2, ADORA2A
12regulation of behaviorGO:05079510.4HTR1B, HTR1D
13prepulse inhibitionGO:06013410.3ADORA2A, DRD2
14response to toxic substanceGO:00963610.3HTR1D, DRD2, SLC6A4
15locomotory behaviorGO:00762610.3ADORA2A, DBH, DRD2, HTR2C
16vasoconstrictionGO:04231010.3SLC6A4, EDNRB, HTR1D, HTR1B
17elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, HTR2C
18response to painGO:04826510.2EDNRB, DBH
19regulation of sensory perception of painGO:05193010.2EDNRB, VIP
20response to drugGO:04249310.1HTR2C, DRD2, SLC6A4, ADORA2A
21associative learningGO:00830610.1GABRA5, DRD2
22vasodilationGO:0423119.9ADORA2A, EDNRB
23synaptic transmissionGO:0072689.8KCNK18, CACNA1A, HTR2C, HTR1B, HTR1D, GABRA5

Molecular functions related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.1DRD2, HTR1B, HTR2C
2serotonin bindingGO:0513789.9HTR1D, HTR1B, HTR2C
3serotonin receptor activityGO:0049939.7HTR1D, HTR1B, HTR2C

Products for genes affiliated with Migraine with Aura

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Sources for Migraine with Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet