MCID: MGR003
MIFTS: 48

Migraine with Aura malady

Neuronal diseases category
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Summaries for Migraine with Aura

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Disease Ontology:8 A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon.

MalaCards based summary: Migraine with Aura, also known as migraine disorders, is related to familial hemiplegic migraine and migraine. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Thyroid hormone signaling pathway and Monoamine Transport. The compounds quetiapine and clozapine have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and brain, and related mouse phenotypes are muscle and integument.

Wikipedia:65 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

Descriptions from OMIM:46 609179,609670

Aliases & Classifications for Migraine with Aura

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Migraine with Aura, Aliases & Descriptions:

Name: Migraine with Aura 8 10 62
Migraine Disorders 62
 
Classic Migraine 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:10024
ICD9CM27 346.0
SNOMED-CT57 4473006, 155047002
MeSH34 D020325

Related Diseases for Migraine with Aura

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Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Symptoms for Migraine with Aura

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Clinical features from OMIM:

609179,609670

Drugs & Therapeutics for Migraine with Aura

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Drug clinical trials:

Search ClinicalTrials for Migraine with Aura

Search NIH Clinical Center for Migraine with Aura

Genetic Tests for Migraine with Aura

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Anatomical Context for Migraine with Aura

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MalaCards organs/tissues related to Migraine with Aura:

32
Eye, Cortex, Brain, Endothelial, Heart, Testes, Liver, Pituitary

Animal Models for Migraine with Aura or affiliated genes

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MGI Mouse Phenotypes related to Migraine with Aura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3ATP1A2, ADORA2A, HTR1B, NOTCH3
2MP:00107718.1ATP1A2, ADORA2A, NOTCH3, DBH
3MP:00053857.6NOTCH3, HTR1B, ADORA2A, DBH, ATP1A2
4MP:00053867.5DBH, ADORA2A, HTR1B, NOTCH3, ATP1A2
5MP:00036317.4DBH, ADORA2A, NOTCH3, KCNK18, ATP1A2

Publications for Migraine with Aura

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Articles related to Migraine with Aura:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Circulating microparticles in migraine with aura: Cause or consequence, a link to stroke. (24715499)
2014
2
Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura. (24885597)
2014
3
Migraine with aura is associated with impaired colour vision: Results from the cross-sectional German DMKG headache study. (25179294)
2014
4
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
5
New-onset migraine with aura after transcatheter closure of atrial septal defect. (22623072)
2012
6
The human I1-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients. (22752568)
2012
7
The borderland of migraine with aura: episodic unilateral mydriasis. (20862508)
2011
8
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). (21252164)
2011
9
Characterization of consistent triggers of migraine with aura. (20847084)
2011
10
Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. (20592202)
2010
11
Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. (20855363)
2010
12
Migraine with aura and the risk of increased mortality. (20736272)
2010
13
Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. (20736269)
2010
14
Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. (19415441)
2009
15
Migraine with aura induced by artificial microbubbles. (19170691)
2009
16
Modulation of visual cortex excitability in migraine with aura: effects of valproate therapy. (19800389)
2009
17
Migraine with aura. (18687723)
2008
18
Does closure of a patent foramen ovale have a role in the treatment of migraine with aura? (18545890)
2008
19
Vertebral artery dissection onset mimics migraine with aura in a graphic designer. (18377386)
2008
20
Hashimoto's encephalopathy mimicking migraine with aura. (17355509)
2007
21
Migraine with aura and restless legs syndrome. (17497271)
2007
22
Abnormalities of Na/K ATPase in migraine with aura. (17257232)
2007
23
The extent of right-to-left shunt fails to correlate with severity of clinical picture in migraine with aura. (16688594)
2006
24
Levetiracetam in the prophylaxis of migraine with aura: a 6-month open-label study. (17095897)
2006
25
Migraine with aura. a risk factor for unprovoked seizures in children? (16718706)
2006
26
Migraine with aura linked to greater cardiovascular disease risk. (17102787)
2006
27
Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura. (17115991)
2006
28
Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. (15313840)
2004
29
Is cardiac evaluation for a possible right-to-left shunt indicated in a scuba diver with migraine with aura? (12603652)
2003
30
Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. (12047331)
2002
31
A prospective study of the headache phase in 32 migraine with aura patients. (12133039)
2002
32
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
33
Migraine with aura after intracranial endovascular procedures. (11318889)
2001
34
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
35
Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. (11075839)
2000
36
Daily migraine with aura: a new migraine variant. (10849034)
2000
37
Resolution of migraine with aura caused by an occipital arteriovenous malformation. (10927806)
2000
38
Long term decline of P100 amplitude in migraine with aura. (10990512)
2000
39
Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study. (10099862)
1999
40
Possible predictive factors in the prognosis of migraine with aura. (10595293)
1999
41
Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. (9513185)
1998
42
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
43
Clinical characteristics and long-term outcome of migraine with aura in children and adolescents. (9003726)
1997
44
Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. (9222191)
1997
45
MRI during migraine with aura. (8606228)
1996
46
Migraine with aura: segregation analysis and heritability estimation. (8682675)
1996
47
Migraine with aura and functional psychosis: a rare differential diagnosis. (8522155)
1995
48
Cerebral blood flow in migraine with aura: a transcranial Doppler sonography study. (1446988)
1992
49
Migraine with aura, cerebral ischemia, spreading depression, and compton scatter. (2016168)
1991
50
Tardive long lasting hyperemia in classic migraine (migraine with aura). (3442799)
1987

Variations for Migraine with Aura

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Expression for genes affiliated with Migraine with Aura

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Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

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Pathways related to Migraine with Aura according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NOTCH3, ATP1A2
2
Show member pathways
Serotonin Transporter Activity37
9.1ADORA2A, DBH

Compounds for genes affiliated with Migraine with Aura

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Sources:
44Novoseek, 50PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1quetiapine44 50 28 24 1113.7HTR1B, ADORA2A
2clozapine44 28 50 1112.5HTR1B, ADORA2A
3maoa449.4DBH, HTR1B
4potassium44 24 1111.4ATP1A2, KCNK18, ADORA2A
5mptp449.4ADORA2A, DBH
6acetic acid44 28 24 1112.4HTR1B, DBH
7opiate449.3DBH, ADORA2A
8propranolol44 28 50 24 1113.3HTR1B, DBH
9lithium44 50 24 1112.2DBH, HTR1B
10phorbol449.1ADORA2A, DBH
11levodopa44 119.9HTR1B, ADORA2A, DBH
12amine448.9HTR1B, ADORA2A, DBH
13cocaine44 119.9DBH, ADORA2A, HTR1B
145-hydroxytryptamine448.9HTR1B, ADORA2A, DBH
15dopamine44 28 24 1111.9DBH, ADORA2A, HTR1B
16cyclic amp44 249.8HTR1B, ADORA2A, DBH
17oxygen44 249.6HTR1B, ADORA2A, DBH
18nitric oxide44 24 1110.5DBH, ADORA2A, HTR1B
19glutamate448.4ADORA2A, DBH, ATP1A2
20calcium44 50 24 1111.0NOTCH3, ADORA2A, DBH, KCNK18, ATP1A2

GO Terms for genes affiliated with Migraine with Aura

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Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.6PRRT2, ATP1A2
2plasma membraneGO:0058867.3NOTCH3, HTR1B, PRRT2, ADORA2A, KCNK18, ATP1A2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5HTR1B, ADORA2A
2potassium ion transportGO:0068139.3KCNK18, ATP1A2
3response to amphetamineGO:0019759.2ADORA2A, DBH
4visual learningGO:0085429.2DBH, ATP1A2
5locomotory behaviorGO:0076269.1ADORA2A, DBH
6synaptic transmissionGO:0072688.7KCNK18, DBH, HTR1B

Products for genes affiliated with Migraine with Aura

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Sources for Migraine with Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet