MCID: MGR003
MIFTS: 53

Migraine with Aura malady

Summaries for Migraine with Aura

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63Wikipedia, 32MalaCards
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Wikipedia:63 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

MalaCards: Migraine with Aura, also known as migraine disorders, is related to migraine and migraine without aura. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Monoamine Transport and Synaptic vesicle cycle. The compounds sb 224289 and cgs-12066 have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and endothelial, and related mouse phenotypes are cardiovascular system and respiratory system.

Aliases & Classifications for Migraine with Aura

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

migraine with aura 8 10 60
migraine disorders 60
classic migraine 8


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Disease Ontology8 DOID:10024
ICD9CM27 346.0
SNOMED-CT56 155047002, 4473006
MeSH34 D020325

Related Diseases for Migraine with Aura

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17GeneCards, 18GeneDecks
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Diseases in the Migraine with Aura family:

Migraine with Aura 9 Migraine with Aura 7

Diseases related to Migraine with Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.1NOTCH3, VIP, KCNK18, CACNA1A, HTR2C, HTR1B
2migraine without aura31.3CACNA1A, ATP1A2
3restless legs syndrome30.6DRD2
4familial hemiplegic migraine30.5ATP1A2, CACNA1A
5cadasil30.4VIP, EDNRB, MTHFR, NOTCH3, ADORA2A
6neuropathy30.2CACNA1A
7hemiplegic migraine30.2CACNA1A, ATP1A2
8obesity30.2DRD2, HTR2C
9ischemia30.2VIP, DRD2, ATP1A2, ADORA2A
10asthma30.2VIP, ADORA2A
11hypertension30.2EDNRB, MTHFR, DBH, SLC6A4
12cerebritis10.7
13patent foramen ovale10.6
14arteriovenous malformation10.5
15stroke, ischemic10.3
16cervicitis10.3
17migraine with aura 910.3
18migraine with aura 710.3
19moyamoya disease10.2
20marfan syndrome10.2
21crohn's disease10.2
22mitral valve prolapse10.2
23prosopagnosia10.2
24arachnoiditis10.2
25ischemic neuropathy10.2
26scotoma10.2
27chronic tic disorder10.2
28fabry disease10.2
29ischemic optic neuropathy10.2
30acute myocardial infarction10.2
31cerebrovascular disease10.2
32leukemia10.2
33meningitis10.2
34myocardial infarction10.2
35tic disorder10.2
36vasculitis10.2
37familial hemiplegic migraine type 110.2
38retinal artery occlusion10.0
39retinitis10.0
40sporadic hemiplegic migraine10.0
41dementia10.0NOTCH3
42wilson disease10.0DRD2
43premature ejaculation10.0SLC6A4
44eating disorder10.0SLC6A4
45heroin dependence10.0DRD2
46borderline personality disorder10.0SLC6A4, HTR1B
47bulimia nervosa10.0HTR1B, SLC6A4
48cluster headache10.0CACNA1A, VIP
49anorexia nervosa10.0SLC6A4, HTR2C
50alternating hemiplegia of childhood10.0ATP1A2

Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Clinical Features for Migraine with Aura

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Drugs & Therapeutics for Migraine with Aura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Migraine with Aura

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Anatomical Context for Migraine with Aura

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32MalaCards
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MalaCards organs/tissues related to Migraine with Aura:

32
Cortex, Brain, Endothelial, Heart, Testes, Liver, Pituitary

Animal Models for Migraine with Aura or affiliated genes

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36MGI
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Publications for Migraine with Aura

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50PubMed
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Articles related to Migraine with Aura:

(show top 50)    (show all 368)
idTitleAuthorsYear
1
Multimodal assessment of optokinetic visual stimulation response in migraine with aura. (23980899)
2014
2
Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. (24134520)
2013
3
Abnormal changes of synaptic excitability in migraine with aura. (22079926)
2012
4
Hemiplegic migraine aura begins with cerebral hypoperfusion: imaging in the acute phase. (21797860)
2011
5
Impaired glutamatergic neurotransmission in migraine with aura? Evidence by an input-output curves transcranial magnetic stimulation study. (21521207)
2011
6
Migraine with aura and the risk of increased mortality. (20736272)
2010
7
Migraine with aura is a risk factor for cervical artery dissection: a case-control study. (20431287)
2010
8
History of migraine with aura and cortical spreading depression from 1941 and onwards. (19740119)
2010
9
Changes in functional vasomotor reactivity in migraine with aura. (19558541)
2009
10
Atrial septal defect closure and migraine with aura: is there a correlation? (19455281)
2009
11
Migraine with aura. (18687723)
2008
12
Vertebral artery dissection onset mimics migraine with aura in a graphic designer. (18377386)
2008
13
Delayed hyperperfusion following migraine with a prolonged aphasic aura in a patient with CADASIL. (18540869)
2008
14
Homeostatic metaplasticity of the motor cortex is altered during headache-free intervals in migraine with aura. (18372292)
2008
15
Hashimoto's encephalopathy mimicking migraine with aura. (17355509)
2007
16
Asymmetric distribution of visual evoked potentials in patients with migraine with aura during the interictal phase. (17932863)
2007
17
The extent of right-to-left shunt fails to correlate with severity of clinical picture in migraine with aura. (16688594)
2006
18
Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. (17116097)
2006
19
The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. (17063315)
2006
20
Sarah Raphael's migraine with aura as inspiration for the Foray of her work into abstraction. (16730510)
2006
21
MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura. (15955037)
2005
22
A high incidence of migraine with aura among morbidly obese women. (15985113)
2005
23
Ictal and interictal hypoactivation of the occipital cortex in migraine with aura. A neuroimaging and electrophysiological study. (16483455)
2005
24
Serotonin 2C receptor gene Cys23Ser polymorphism: a candidate genetic risk factor of migraine with aura in Japanese population. (15147464)
2004
25
Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine. (12601098)
2003
26
Treatment of migraine with aura: comments and perspectives. (12624713)
2003
27
Familial occurrence of migraine with aura in a population-based study. (12603641)
2003
28
An epidemiological study of migraine with aura in the San Severo general population: a pilot research project of cooperation between neurologists and general practitioners. (14634262)
2003
29
Transformation into daily migraine with aura following transcutaneous atrial septal defect closure. (12752756)
2003
30
A prospective study of the headache phase in 32 migraine with aura patients. (12133039)
2002
31
Dopamine receptor genes and migraine with and without aura: an association study. (12047334)
2002
32
Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study. (12110110)
2002
33
Modulation of visual cortical excitability in migraine with aura: effects of 1 Hz repetitive transcranial magnetic stimulation. (12110957)
2002
34
Genetics of migraine without aura, migraine with aura, migrainous disorder, head trauma migraine without aura and tension-type headache. (11595012)
2001
35
Acetazolamide for the treatment of migraine with aura in CADASIL. (11739850)
2001
36
Migraine with aura and white matter abnormalities: Notch3 mutation. (10802804)
2000
37
Potential source of cerebral embolism in migraine with aura: a transcranial Doppler study. (10599818)
1999
38
Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura. (9952029)
1999
39
Migraine with aura-like headache associated with moyamoya disease. (10442455)
1999
40
Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. (9513185)
1998
41
Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? (9876885)
1998
42
The D2 receptor NcoI allele: absence of allelic association with migraine with aura. (9748084)
1998
43
Hyperbaric oxygen in the treatment of migraine with aura. (9529766)
1998
44
Frequency of factor V Leiden in juvenile migraine with aura. (11279903)
1998
45
Migraine without aura and migraine with aura are inherited disorders. (8869764)
1996
46
Migraine with aura and functional psychosis: a rare differential diagnosis. (8522155)
1995
47
Sex-hormone-related events in migrainous females. A clinical comparative study between migraine with aura and migraine without aura. (7641250)
1995
48
In vivo effects of alprazolam and lorazepam on the immune response in patients with migraine without aura. (8227969)
1993
49
Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura. (1603349)
1992
50
Tardive long lasting hyperemia in classic migraine (migraine with aura). (3442799)
1987

Genetic Variations for Migraine with Aura

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Expression for genes affiliated with Migraine with Aura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

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37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Migraine with Aura

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1sb 2242892810.4HTR2C, HTR1B, HTR1D
2cgs-120662810.4HTR1D, HTR2C, HTR1B
3ketanserin28 4411.4HTR1D, DRD2, SLC6A4, HTR1B
4sb 2166412810.4HTR1D, HTR1B, HTR2C
5s330842810.4HTR2C, HTR1D, HTR1B
6roxindole28 4411.3DRD2, HTR1D, HTR1B, HTR2C
7antipsychotics4910.3HTR2C, MTHFR, DRD2
8terguride28 4411.3HTR2C, HTR1D, HTR1B, DRD2
9ritanserin28 4411.3HTR2C, HTR1D, DRD2, HTR1B
10sertindole28 44 1112.3DRD2, HTR1D, HTR1B, HTR2C
11tfmpp2810.3HTR1B, HTR2C, HTR1D
12ropinirole44 1111.3DRD2, HTR1B, HTR1D, HTR2C
13mcpp4410.3HTR2C, HTR1B, SLC6A4
14lisuride28 44 1112.3HTR2C, DRD2, HTR1B, HTR1D
15pergolide28 44 1112.3HTR1D, HTR2C, DRD2, HTR1B
16ergotamine28 44 1112.3HTR1B, DRD2, HTR1D, HTR2C
17pramipexole44 49 28 1113.3DRD2, HTR2C, HTR1B, HTR1D
18maoa4410.3SLC6A4, HTR2C, HTR1B, DRD2, DBH
19asenapine28 1111.3HTR2C, HTR1B, HTR1D, DRD2
20cabergoline28 44 1112.3HTR1D, DRD2, HTR1B, HTR2C
21aripiprazole28 49 44 11 2414.3DRD2, HTR1D, HTR1B, HTR2C
22gr-1279352810.3HTR1D, HTR1B, HTR2C
23ziprasidone49 28 44 1113.2HTR1B, DRD2, HTR1D, HTR2C
24brl-155722810.2HTR1D, HTR1B, HTR2C
25levodopa44 1111.2ADORA2A, DBH, MTHFR, DRD2, HTR1B
26quetiapine44 49 28 11 2414.2ADORA2A, HTR2C, HTR1D, HTR1B, DRD2
27yohimbine44 28 2 1113.2DRD2, HTR1D, HTR1B, HTR2C
28sl65.01552810.2HTR1B, HTR1D, HTR2C
29apomorphine44 28 1112.2HTR2C, HTR1B, HTR1D, DRD2
30bromocriptine28 44 1112.2DRD2, HTR1B, HTR2C, VIP, HTR1D
31risperidone28 44 49 59 11 2415.2SLC6A4, HTR1D, HTR1B, HTR2C, DRD2
32ly3448642810.2HTR2C, HTR1B, HTR1D
33propranolol44 28 49 11 2414.2DBH, HTR1D, VIP, HTR1B, HTR2C
34ru 2496928 4411.2HTR1D, HTR1B, HTR2C
35cocaine44 1111.1HTR1B, DRD2, DBH, SLC6A4, ADORA2A, HTR2C
36haloperidol44 28 2 49 1114.1VIP, HTR1D, DRD2, SLC6A4, ADORA2A
375-meot2810.1HTR1D, HTR1B, HTR2C
38amine4410.1ADORA2A, SLC6A4, DBH, HTR1D, HTR1B, HTR2C
39clozapine44 28 49 1113.1HTR2C, HTR1B, HTR1D, DRD2, SLC6A4, ADORA2A
40oxymetazoline28 44 1112.0HTR2C, HTR1B, HTR1D
41acetylcholine44 49 28 11 2414.0EDNRB, CACNA1A, DBH, ADORA2A, DRD2, HTR2C
42fluoxetine49 44 28 1113.0DRD2, SLC6A4, HTR2C, HTR1B
43gaba449.9GABRA5, VIP, HTR2C, DRD2, DBH, SLC6A4
448-oh-dpat289.9HTR2C, HTR1D, HTR1B
45norepinephrine44 11 2411.8SLC6A4, ADORA2A, EDNRB, HTR2C, DRD2, HTR1D
46adenylate449.8DBH, DRD2, ADORA2A, HTR1D, EDNRB, HTR2C
47minaprine44 1110.8SLC6A4, DRD2, HTR2C
485-hydroxytryptamine449.7HTR1D, HTR2C, VIP, HTR1B, DRD2, EDNRB
49dopamine44 28 11 2412.7ADORA2A, SLC6A4, DBH, MTHFR, DRD2, HTR1D
50glutamate449.6ADORA2A, EDNRB, VIP, CACNA1A, HTR2C, DRD2

GO Terms for genes affiliated with Migraine with Aura

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16Gene Ontology
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Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.9ADORA2A, GABRA5, DRD2, CACNA1A
2integral to plasma membraneGO:0058879.1ADORA2A, KCNK18, HTR2C, HTR1B, HTR1D, DRD2
3plasma membraneGO:0058868.6HTR1D, HTR1B, HTR2C, CACNA1A, KCNK18, DRD2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.5ATP1A2, DRD2
2positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5ADORA2A, VIP
3behavioral response to ethanolGO:04814910.5DBH, DRD2
4negative regulation of synaptic transmission, glutamatergicGO:05196710.5DRD2, HTR1B
5regulation of dopamine secretionGO:01405910.5HTR1B, DRD2
6positive regulation of urine volumeGO:03581010.4ADORA2A, EDNRB, DRD2
7G-protein coupled receptor internalizationGO:00203110.4HTR1B, DRD2
8visual learningGO:00854210.4DRD2, ATP1A2, DBH
9positive regulation of renal sodium excretionGO:03581510.4DRD2, EDNRB, ADORA2A
10response to amphetamineGO:00197510.4ADORA2A, DBH, DRD2
11synaptic transmission, dopaminergicGO:00196310.4DRD2, ADORA2A
12regulation of behaviorGO:05079510.4HTR1B, HTR1D
13prepulse inhibitionGO:06013410.3ADORA2A, DRD2
14response to toxic substanceGO:00963610.3HTR1D, DRD2, SLC6A4
15locomotory behaviorGO:00762610.3ADORA2A, DBH, DRD2, HTR2C
16vasoconstrictionGO:04231010.3SLC6A4, EDNRB, HTR1D, HTR1B
17elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, HTR2C
18response to painGO:04826510.2EDNRB, DBH
19regulation of sensory perception of painGO:05193010.2EDNRB, VIP
20response to drugGO:04249310.1HTR2C, DRD2, SLC6A4, ADORA2A
21associative learningGO:00830610.1GABRA5, DRD2
22vasodilationGO:0423119.9ADORA2A, EDNRB
23synaptic transmissionGO:0072689.8KCNK18, CACNA1A, HTR2C, HTR1B, HTR1D, GABRA5

Molecular functions related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.1DRD2, HTR1B, HTR2C
2serotonin bindingGO:0513789.9HTR1D, HTR1B, HTR2C
3serotonin receptor activityGO:0049939.7HTR1D, HTR1B, HTR2C

Products for genes affiliated with Migraine with Aura

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Sources for Migraine with Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet