MCID: MGR003
MIFTS: 53

Migraine with Aura malady

Summaries for Migraine with Aura

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63Wikipedia, 32MalaCards
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Wikipedia:63 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

MalaCards: Migraine with Aura, also known as migraine disorders, is related to migraine and migraine without aura. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Monoamine Transport and Synaptic vesicle cycle. The compounds cgs-12066 and sb 224289 have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and endothelial, and related mouse phenotypes are cardiovascular system and respiratory system.

Aliases & Classifications for Migraine with Aura

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

migraine with aura 8 10 60
migraine disorders 60
classic migraine 8


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Disease Ontology8 DOID:10024
ICD9CM27 346.0
SNOMED-CT56 155047002, 4473006
MeSH34 D020325

Related Diseases for Migraine with Aura

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17GeneCards, 18GeneDecks
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Diseases in the Migraine with Aura family:

Migraine with Aura 9 Migraine with Aura 7

Diseases related to Migraine with Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.1NOTCH3, VIP, KCNK18, CACNA1A, HTR2C, HTR1B
2migraine without aura31.3CACNA1A, ATP1A2
3restless legs syndrome30.6DRD2
4familial hemiplegic migraine30.5ATP1A2, CACNA1A
5cadasil30.4VIP, EDNRB, MTHFR, NOTCH3, ADORA2A
6neuropathy30.2CACNA1A
7hemiplegic migraine30.2CACNA1A, ATP1A2
8obesity30.2DRD2, HTR2C
9ischemia30.2VIP, DRD2, ATP1A2, ADORA2A
10asthma30.2VIP, ADORA2A
11hypertension30.2EDNRB, MTHFR, DBH, SLC6A4
12cerebritis10.7
13patent foramen ovale10.6
14arteriovenous malformation10.5
15stroke, ischemic10.3
16cervicitis10.3
17migraine with aura 910.3
18migraine with aura 710.3
19moyamoya disease10.2
20marfan syndrome10.2
21crohn's disease10.2
22mitral valve prolapse10.2
23prosopagnosia10.2
24arachnoiditis10.2
25ischemic neuropathy10.2
26scotoma10.2
27chronic tic disorder10.2
28fabry disease10.2
29ischemic optic neuropathy10.2
30acute myocardial infarction10.2
31cerebrovascular disease10.2
32leukemia10.2
33meningitis10.2
34myocardial infarction10.2
35tic disorder10.2
36vasculitis10.2
37familial hemiplegic migraine type 110.2
38retinal artery occlusion10.0
39retinitis10.0
40sporadic hemiplegic migraine10.0
41dementia10.0NOTCH3
42wilson disease10.0DRD2
43premature ejaculation10.0SLC6A4
44eating disorder10.0SLC6A4
45heroin dependence10.0DRD2
46borderline personality disorder10.0SLC6A4, HTR1B
47bulimia nervosa10.0HTR1B, SLC6A4
48cluster headache10.0CACNA1A, VIP
49anorexia nervosa10.0SLC6A4, HTR2C
50alternating hemiplegia of childhood10.0ATP1A2

Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Clinical Features for Migraine with Aura

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Drugs & Therapeutics for Migraine with Aura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Migraine with Aura

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Genetic Tests for Migraine with Aura

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Anatomical Context for Migraine with Aura

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32MalaCards
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MalaCards organs/tissues related to Migraine with Aura:

32
Cortex, Brain, Endothelial, Testes, Heart, Liver, Pituitary

Animal Models for Migraine with Aura or affiliated genes

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36MGI
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Publications for Migraine with Aura

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50PubMed
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Articles related to Migraine with Aura:

(show top 50)    (show all 368)
idTitleAuthorsYear
1
Transient unilateral spatial neglect during aura in a woman with sporadic hemiplegic migraine. (23674829)
2013
2
Diagnostic delay in migraine with aura. (23695065)
2013
3
Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura. (23043936)
2013
4
Alexithymia and its impact on quality of life in a group of Brazilian women with migraine without aura. (23565860)
2013
5
New-onset migraine with aura after transcatheter closure of atrial septal defect. (22623072)
2012
6
Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM). (22933508)
2012
7
Migraine with aura in patients over 50 years of age: the Marseillea89s registry. (22302276)
2012
8
Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. (23109150)
2012
9
Characterization of consistent triggers of migraine with aura. (20847084)
2011
10
Asymmetry of visual function in migraine with aura: correlation with lateralisation of headache and aura. (20663857)
2011
11
Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura. (20740293)
2010
12
Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation. (20621801)
2010
13
Migraine with aura induced by efalizumab. (19549238)
2009
14
Cerebral vasculitis mimicking migraine with aura in a patient with Crohn's disease. (19402574)
2009
15
Reduced cerebellar inhibition in migraine with aura: a TMS study. (19156474)
2009
16
Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report. (18624711)
2009
17
Does closure of a patent foramen ovale have a role in the treatment of migraine with aura? (18545890)
2008
18
Patent foramen ovale detected by near-infrared spectroscopy in patients suffering from migraine with aura. (18545930)
2008
19
Replication study of the insulin receptor gene in migraine with aura. (18455362)
2008
20
Stereotyped topography of different elevated contingent negative variation components in children with migraine without aura points towards a subcortical dysfunction. (17027155)
2007
21
Diffusion MRI during migraine with aura attack associated with diagnostic microbubbles injection in subjects with large PFO. (18052957)
2007
22
Anger, depression and personality dimensions in patients with migraine without aura. (17230053)
2007
23
Levetiracetam in the prophylaxis of migraine with aura: a 6-month open-label study. (17095897)
2006
24
Migraine aura without headache compared to migraine with aura in patients with affective disorders. (16362710)
2005
25
Facilitatory effects of 1 Hz rTMS in motor cortex of patients affected by migraine with aura. (15480599)
2005
26
High prevalence of patent foramen ovale in migraine with aura. (16362645)
2005
27
Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms. (15109354)
2004
28
Is cardiac evaluation for a possible right-to-left shunt indicated in a scuba diver with migraine with aura? (12603652)
2003
29
Genetic loading in familial migraine with aura. (12876251)
2003
30
Acupuncture in the prophylactic treatment of migraine without aura: a comparison with flunarizine. (12390610)
2002
31
Migraine with aura versus migraine without aura: pain intensity and associated symptom intensities after placebo. (12390612)
2002
32
Re: "Daily migraine with aura: a new migraine variant" (Merims D., Kuritzky A. Headache. 2000;40:389-392). (11168613)
2001
33
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
34
Resolution of migraine with aura caused by an occipital arteriovenous malformation. (10927806)
2000
35
Possible risk factors and precipitants for migraine with aura in discordant twin-pairs: a population-based study. (11167911)
2000
36
Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study. (10099862)
1999
37
Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. (9989627)
1999
38
Pattern reversal visual evoked potentials in migraine with aura and migraine aura without headache. (9731935)
1998
39
Migraine with aura: a review of 81 patients at 10-20 years' follow-up. (9950627)
1998
40
Interictal and ictal phase study with Tc 99m HMPAO brain SPECT in juvenile migraine with aura. (9046721)
1997
41
Thresholds for detection of a target against a background grating suggest visual dysfunction in migraine with aura but not migraine without aura. (7641245)
1995
42
Cerebrovascular CO2 reactivity in migraine with aura and without aura. A transcranial Doppler study. (7484067)
1995
43
Visual dysfunction in migraine with aura. (8706119)
1995
44
Migraine with aura and migraine without aura: one entity, two, or more? (7553805)
1995
45
Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura. (7515329)
1994
46
Cerebral blood flow in migraine with aura: a transcranial Doppler sonography study. (1446988)
1992
47
Visual field loss after attacks of migraine with aura. (1473135)
1992
48
Magnetic resonance image abnormality in migraine with aura. (1889071)
1991
49
Exaggerated spontaneous release of tumor necrosis factor-alpha/cachectin in patients with migraine without aura. (2251950)
1990
50
Cerebral mapping in subjects suffering from migraine with aura. (2289228)
1990

Genetic Variations for Migraine with Aura

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Expression for genes affiliated with Migraine with Aura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

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37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Migraine with Aura

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1cgs-120662810.4HTR1D, HTR1B, HTR2C
2sb 2242892810.4HTR2C, HTR1B, HTR1D
3ketanserin28 4411.4SLC6A4, DRD2, HTR1D, HTR1B
4s330842810.4HTR1B, HTR2C, HTR1D
5sb 2166412810.4HTR1B, HTR1D, HTR2C
6roxindole28 4411.3HTR2C, DRD2, HTR1D, HTR1B
7antipsychotics4910.3DRD2, HTR2C, MTHFR
8terguride28 4411.3DRD2, HTR1D, HTR2C, HTR1B
9ritanserin28 4411.3HTR2C, HTR1B, HTR1D, DRD2
10sertindole28 44 1112.3DRD2, HTR2C, HTR1D, HTR1B
11tfmpp2810.3HTR1B, HTR2C, HTR1D
12ropinirole44 1111.3HTR1B, HTR2C, DRD2, HTR1D
13lisuride28 44 1112.3HTR1D, DRD2, HTR2C, HTR1B
14pergolide28 44 1112.3HTR2C, DRD2, HTR1B, HTR1D
15ergotamine28 44 1112.3HTR2C, HTR1B, HTR1D, DRD2
16pramipexole44 49 28 1113.3HTR1D, HTR2C, HTR1B, DRD2
17maoa4410.3DBH, SLC6A4, HTR2C, HTR1B, DRD2
18asenapine28 1111.3HTR1D, HTR1B, DRD2, HTR2C
19cabergoline28 44 1112.3HTR1D, HTR2C, DRD2, HTR1B
20sl65.01552810.3HTR2C, HTR1D, HTR1B
21aripiprazole28 49 44 11 2414.3HTR2C, HTR1B, HTR1D, DRD2
22gr-1279352810.3HTR1D, HTR1B, HTR2C
23ziprasidone49 28 44 1113.2HTR2C, HTR1B, HTR1D, DRD2
24ly3448642810.2HTR2C, HTR1B, HTR1D
25levodopa44 1111.2ADORA2A, MTHFR, DBH, HTR1B, DRD2
26mcpp4410.2SLC6A4, HTR2C, HTR1B
27quetiapine44 49 28 11 2414.2HTR1B, DRD2, ADORA2A, HTR1D, HTR2C
28yohimbine44 28 2 1113.2HTR2C, HTR1B, HTR1D, DRD2
29brl-155722810.2HTR1B, HTR2C, HTR1D
30apomorphine44 28 1112.2DRD2, HTR1D, HTR2C, HTR1B
31bromocriptine28 44 1112.2VIP, HTR2C, HTR1B, DRD2, HTR1D
32risperidone28 44 49 59 11 2415.2HTR1D, HTR1B, DRD2, HTR2C, SLC6A4
33propranolol44 28 49 11 2414.2DBH, HTR1D, HTR1B, HTR2C, VIP
34ru 2496928 4411.2HTR1D, HTR1B, HTR2C
35cocaine44 1111.1HTR1B, SLC6A4, ADORA2A, DBH, HTR2C, DRD2
36haloperidol44 28 2 49 1114.1VIP, HTR1D, SLC6A4, ADORA2A, DRD2
375-meot2810.1HTR1D, HTR1B, HTR2C
38amine4410.1HTR2C, ADORA2A, HTR1D, DBH, HTR1B, SLC6A4
39clozapine44 28 49 1113.1ADORA2A, SLC6A4, HTR1B, DRD2, HTR1D, HTR2C
40ipsapirone44 2811.0HTR2C, HTR1B, HTR1D
41acetylcholine44 49 28 11 2414.0EDNRB, HTR2C, DRD2, VIP, DBH, ADORA2A
42fluoxetine49 44 28 1113.0SLC6A4, DRD2, HTR1B, HTR2C
43gaba449.9ADORA2A, VIP, HTR2C, GABRA5, DBH, SLC6A4
44oxymetazoline28 44 1111.9HTR2C, HTR1B, HTR1D
45norepinephrine44 11 2411.8EDNRB, DBH, HTR1D, ADORA2A, HTR2C, DRD2
46adenylate449.8ADORA2A, DBH, EDNRB, DRD2, HTR1D, HTR2C
475-carboxamidotryptamine449.7HTR2C, HTR1D, HTR1B
485-hydroxytryptamine449.7DRD2, ADORA2A, SLC6A4, DBH, VIP, HTR2C
49dopamine44 28 11 2412.7VIP, HTR1B, HTR1D, DRD2, MTHFR, DBH
50glutamate449.6DBH, ADORA2A, MTHFR, EDNRB, VIP, SLC6A4

GO Terms for genes affiliated with Migraine with Aura

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16Gene Ontology
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Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.9ADORA2A, GABRA5, DRD2, CACNA1A
2integral to plasma membraneGO:0058879.1ADORA2A, SLC6A4, EDNRB, GABRA5, DRD2, HTR1D
3plasma membraneGO:0058868.6ADORA2A, KCNK18, CACNA1A, NOTCH3, SLC6A4, ATP1A2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.5ATP1A2, DRD2
2positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5ADORA2A, VIP
3behavioral response to ethanolGO:04814910.5DBH, DRD2
4negative regulation of synaptic transmission, glutamatergicGO:05196710.5DRD2, HTR1B
5regulation of dopamine secretionGO:01405910.5HTR1B, DRD2
6positive regulation of urine volumeGO:03581010.4ADORA2A, EDNRB, DRD2
7G-protein coupled receptor internalizationGO:00203110.4HTR1B, DRD2
8visual learningGO:00854210.4DRD2, ATP1A2, DBH
9positive regulation of renal sodium excretionGO:03581510.4DRD2, EDNRB, ADORA2A
10response to amphetamineGO:00197510.4ADORA2A, DBH, DRD2
11synaptic transmission, dopaminergicGO:00196310.4DRD2, ADORA2A
12regulation of behaviorGO:05079510.4HTR1B, HTR1D
13prepulse inhibitionGO:06013410.3ADORA2A, DRD2
14response to toxic substanceGO:00963610.3HTR1D, DRD2, SLC6A4
15locomotory behaviorGO:00762610.3ADORA2A, DBH, DRD2, HTR2C
16vasoconstrictionGO:04231010.3SLC6A4, EDNRB, HTR1D, HTR1B
17elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, HTR2C
18response to painGO:04826510.2EDNRB, DBH
19regulation of sensory perception of painGO:05193010.2EDNRB, VIP
20response to drugGO:04249310.1HTR2C, DRD2, SLC6A4, ADORA2A
21associative learningGO:00830610.1GABRA5, DRD2
22vasodilationGO:0423119.9ADORA2A, EDNRB
23synaptic transmissionGO:0072689.8KCNK18, CACNA1A, HTR2C, HTR1B, HTR1D, GABRA5

Molecular functions related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.1DRD2, HTR1B, HTR2C
2serotonin bindingGO:0513789.9HTR1D, HTR1B, HTR2C
3serotonin receptor activityGO:0049939.7HTR1D, HTR1B, HTR2C

Products for genes affiliated with Migraine with Aura

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Sources for Migraine with Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet