MCID: MGR003
MIFTS: 46

Migraine with Aura malady

Neuronal diseases category
Download this MalaCard

Summaries for Migraine with Aura

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 An aura is a perceptual disturbance experienced by some with migraine or seizures before either the... more...

MalaCards: Migraine with Aura, also known as migraine disorders, is related to migraine and familial hemiplegic migraine. An important gene associated with Migraine with Aura is KCNK18 (potassium channel, subfamily K, member 18), and among its related pathways are Thyroid hormone signaling pathway and Monoamine Transport. The compounds quetiapine and clozapine have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and brain, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Migraine with Aura

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH, 27ICD9CM, 58SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

migraine with aura 8 10 62
migraine disorders 62
classic migraine 8


External Ids:

Disease Ontology8 DOID:10024
MeSH35 D020325
SNOMED-CT58 4473006, 155047002
ICD9CM27 346.0

Related Diseases for Migraine with Aura

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Migraine with Aura:



Diseases related to migraine with aura

Symptoms for Migraine with Aura

About this section

Drugs & Therapeutics for Migraine with Aura

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Migraine with Aura

Search NIH Clinical Center for Migraine with Aura

Genetic Tests for Migraine with Aura

About this section

Anatomical Context for Migraine with Aura

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Migraine with Aura:

33
Eye, Cortex, Brain, Endothelial, Heart, Testes, Liver, Pituitary

Animal Models for Migraine with Aura or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Migraine with Aura:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3ATP1A2, ADORA2A, HTR1B, NOTCH3
2MP:00107718.1ATP1A2, ADORA2A, NOTCH3, DBH
3MP:00053857.6NOTCH3, HTR1B, ADORA2A, DBH, ATP1A2
4MP:00053867.5DBH, ADORA2A, HTR1B, NOTCH3, ATP1A2
5MP:00036317.4DBH, ADORA2A, NOTCH3, KCNK18, ATP1A2

Publications for Migraine with Aura

About this section
Sources:
52PubMed
See all sources

Articles related to Migraine with Aura:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
White matter lesions progression in migraine with aura: a clinical and MRI longitudinal study. (22268442)
2013
2
Posterior circulation embolism as a potential mechanism for migraine with aura. (22523188)
2012
3
New-onset migraine with aura after transcatheter closure of atrial septal defect. (22623072)
2012
4
The human I1-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients. (22752568)
2012
5
The borderland of migraine with aura: episodic unilateral mydriasis. (20862508)
2011
6
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). (21252164)
2011
7
Characterization of consistent triggers of migraine with aura. (20847084)
2011
8
Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. (20592202)
2010
9
Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. (20855363)
2010
10
Migraine with aura and the risk of increased mortality. (20736272)
2010
11
Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. (20736269)
2010
12
Migraine with aura induced by artificial microbubbles. (19170691)
2009
13
Modulation of visual cortex excitability in migraine with aura: effects of valproate therapy. (19800389)
2009
14
New genetic evidence for involvement of the dopamine system in migraine with aura. (19152006)
2009
15
Migraine with aura. (18687723)
2008
16
Does closure of a patent foramen ovale have a role in the treatment of migraine with aura? (18545890)
2008
17
Vertebral artery dissection onset mimics migraine with aura in a graphic designer. (18377386)
2008
18
Hashimoto's encephalopathy mimicking migraine with aura. (17355509)
2007
19
Migraine with aura and restless legs syndrome. (17497271)
2007
20
Abnormalities of Na/K ATPase in migraine with aura. (17257232)
2007
21
Migraine with aura and ischemic stroke: which additional factors matter? (17690307)
2007
22
The extent of right-to-left shunt fails to correlate with severity of clinical picture in migraine with aura. (16688594)
2006
23
Levetiracetam in the prophylaxis of migraine with aura: a 6-month open-label study. (17095897)
2006
24
Migraine with aura. a risk factor for unprovoked seizures in children? (16718706)
2006
25
Migraine with aura linked to greater cardiovascular disease risk. (17102787)
2006
26
Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura. (17115991)
2006
27
Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. (15313840)
2004
28
Is cardiac evaluation for a possible right-to-left shunt indicated in a scuba diver with migraine with aura? (12603652)
2003
29
Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine. (12601098)
2003
30
Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. (12047331)
2002
31
A prospective study of the headache phase in 32 migraine with aura patients. (12133039)
2002
32
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
33
Migraine with aura after intracranial endovascular procedures. (11318889)
2001
34
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
35
Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. (11075839)
2000
36
Daily migraine with aura: a new migraine variant. (10849034)
2000
37
Resolution of migraine with aura caused by an occipital arteriovenous malformation. (10927806)
2000
38
Long term decline of P100 amplitude in migraine with aura. (10990512)
2000
39
Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study. (10099862)
1999
40
Possible predictive factors in the prognosis of migraine with aura. (10595293)
1999
41
Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. (9513185)
1998
42
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
43
Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? (9876885)
1998
44
Clinical characteristics and long-term outcome of migraine with aura in children and adolescents. (9003726)
1997
45
Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. (9222191)
1997
46
MRI during migraine with aura. (8606228)
1996
47
Migraine with aura: segregation analysis and heritability estimation. (8682675)
1996
48
Migraine with aura and functional psychosis: a rare differential diagnosis. (8522155)
1995
49
Cerebral blood flow in migraine with aura: a transcranial Doppler sonography study. (1446988)
1992
50
Migraine with aura, cerebral ischemia, spreading depression, and compton scatter. (2016168)
1991

Variations for Migraine with Aura

About this section

Expression for genes affiliated with Migraine with Aura

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Migraine with Aura

Search GEO for disease gene expression data for Migraine with Aura.

Pathways for genes affiliated with Migraine with Aura

About this section
Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Migraine with Aura according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NOTCH3, ATP1A2
2
Show member pathways
Serotonin Transporter Activity38
9.1ADORA2A, DBH

Compounds for genes affiliated with Migraine with Aura

About this section
Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Migraine with Aura according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1quetiapine45 51 29 24 1113.7HTR1B, ADORA2A
2clozapine45 29 51 1112.5HTR1B, ADORA2A
3maoa459.4DBH, HTR1B
4potassium45 24 1111.4ATP1A2, KCNK18, ADORA2A
5mptp459.4ADORA2A, DBH
6acetic acid45 29 24 1112.4HTR1B, DBH
7opiate459.3DBH, ADORA2A
8propranolol45 29 51 24 1113.3HTR1B, DBH
9lithium45 51 24 1112.2DBH, HTR1B
10phorbol459.1ADORA2A, DBH
11levodopa45 119.9HTR1B, ADORA2A, DBH
12amine458.9HTR1B, ADORA2A, DBH
13cocaine45 119.9DBH, ADORA2A, HTR1B
145-hydroxytryptamine458.9HTR1B, ADORA2A, DBH
15dopamine45 29 24 1111.9DBH, ADORA2A, HTR1B
16cyclic amp45 249.8HTR1B, ADORA2A, DBH
17oxygen45 249.6HTR1B, ADORA2A, DBH
18nitric oxide45 24 1110.5DBH, ADORA2A, HTR1B
19glutamate458.4ADORA2A, DBH, ATP1A2
20calcium45 51 24 1111.0NOTCH3, ADORA2A, DBH, KCNK18, ATP1A2

GO Terms for genes affiliated with Migraine with Aura

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synapseGO:0452029.6PRRT2, ATP1A2
2plasma membraneGO:0058867.3NOTCH3, HTR1B, PRRT2, ADORA2A, KCNK18, ATP1A2

Biological processes related to Migraine with Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5HTR1B, ADORA2A
2potassium ion transportGO:0068139.3KCNK18, ATP1A2
3response to amphetamineGO:0019759.2ADORA2A, DBH
4visual learningGO:0085429.2DBH, ATP1A2
5locomotory behaviorGO:0076269.1ADORA2A, DBH
6synaptic transmissionGO:0072688.7KCNK18, DBH, HTR1B

Products for genes affiliated with Migraine with Aura

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Migraine with Aura

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet