MCID: MGR028
MIFTS: 47

Migraine with or Without Aura 1 malady

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Migraine with or Without Aura 1

Aliases & Descriptions for Migraine with or Without Aura 1:

Name: Migraine with or Without Aura 1 54
Migraine 54 12 51 52 41 14
Migraine Without Aura 54 12 42 14
Migraine Variant 12 29 69
Common Migraine 12 52 69
Migraine Disorders 42 69
Migraine with or Without Aura, Susceptibility to, 1 13
Migraine with or Without Aura 12
Migraine Disorder 12

Characteristics:

HPO:

32
migraine with or without aura 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Migraine with or Without Aura 1

OMIM : 54 Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for... (157300) more...

MalaCards based summary : Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine with aura, and has symptoms including photophobia, nausea and vomiting. An important gene associated with Migraine with or Without Aura 1 is EDNRA (Endothelin Receptor Type A). The drugs Aspirin and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain.

Disease Ontology : 12 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

MedlinePlus : 41 if you suffer from migraine headaches, you're not alone. about 12 percent of the u.s. population gets them. migraines are recurring attacks of moderate to severe pain. the pain is throbbing or pulsing, and is often on one side of the head. during migraines, people are very sensitive to light and sound. they may also become nauseated and vomit. migraine is three times more common in women than in men. some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision. many things can trigger a migraine. these include anxiety stress lack of food or sleep exposure to light hormonal changes (in women) doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. now they believe the cause is related to genes that control the activity of some brain cells. medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. for many people, treatments to relieve stress can also help. nih: national institute of neurological disorders and stroke

NINDS : 51 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.  Migraine in some women may relate to changes in hormones and hormonal levels during their menstrual cycle.  For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine has a genetic cause.

Related Diseases for Migraine with or Without Aura 1

Diseases related to Migraine with or Without Aura 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
id Related Disease Score Top Affiliating Genes
1 familial hemiplegic migraine 12.5
2 migraine with aura 12.3
3 migraine, familial hemiplegic, 2 12.2
4 migraine, familial hemiplegic, 3 12.2
5 migraine with brainstem aura 12.2
6 sporadic hemiplegic migraine 12.2
7 migraine, familial hemiplegic, 1 12.2
8 hemiplegic migraine 12.2
9 migraine, with or without aura 13 12.1
10 migraine with or without aura 5 11.9
11 familial or sporadic hemiplegic migraine 11.9
12 migraine with or without aura 3 11.7
13 migraine with aura 9 11.7
14 migraine without aura 4 11.7
15 migraine, familial typical 2 11.7
16 migraine with aura 7 11.7
17 migraine with or without aura 6 11.7
18 migraine with or without aura, susceptibility 13 11.7
19 cyclic vomiting syndrome 11.6
20 headache 11.3
21 epilepsy, familial temporal lobe, 4 11.3
22 handl syndrome 11.3
23 episodic ataxia 11.3
24 alternating hemiplegia of childhood 11.2
25 trochleitis 11.2
26 cadasil 11.1
27 hemicrania continua 11.1
28 carotidynia 11.1
29 cluster headache 11.0
30 episodic ataxia, type 2 11.0
31 new daily-persistent headache 10.9
32 alpha-methylacyl-coa racemase deficiency 10.8
33 vasculopathy, retinal, with cerebral leukodystrophy 10.8
34 peroxisome biogenesis disorder 14b 10.8
35 cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 10.8
36 dystonia 9 10.8
37 basal ganglia calcification, idiopathic, 4 10.6
38 mitochondrial recessive ataxia syndrome 10.6
39 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 10.6
40 primary familial brain calcification 10.6
41 orthostatic intolerance 10.6
42 valproate embryopathy, susceptibility to 10.6
43 hyperacusis 10.6
44 riboflavin deficiency 10.6
45 ariboflavinosis 10.6
46 adie pupil 10.6
47 sturge-weber syndrome, somatic, mosaic 10.6
48 cadasil 1 10.6
49 benign epilepsy with centrotemporal spikes 10.6
50 col4a1-related brain small-vessel disease 10.6

Comorbidity relations with Migraine with or Without Aura 1 via Phenotypic Disease Network (PDN):


Anxiety Disorder Esophagitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Migraine with or Without Aura 1:



Diseases related to Migraine with or Without Aura 1

Symptoms & Phenotypes for Migraine with or Without Aura 1

Symptoms by clinical synopsis from OMIM:

157300

Clinical features from OMIM:

157300

Human phenotypes related to Migraine with or Without Aura 1:

32 (show all 6)
id Description HPO Frequency HPO Source Accession
1 photophobia 32 HP:0000613
2 nausea 32 HP:0002018
3 vomiting 32 HP:0002013
4 phonophobia 32 HP:0002183
5 migraine with aura 32 HP:0002077
6 migraine without aura 32 HP:0002083

UMLS symptoms related to Migraine with or Without Aura 1:


back pain, headache, hemiplegia, nausea, pain, sciatica, seizures, syncope, tremor, chronic pain, scotoma, scintillating, vertigo/dizziness, hemicrania, sleeplessness, recurrent paroxysmal headache

Drugs & Therapeutics for Migraine with or Without Aura 1

Drugs for Migraine with or Without Aura 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 503)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
2
Ticlopidine Approved Phase 4 55142-85-3 5472
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
4
Ketorolac Approved Phase 4,Phase 2,Phase 3,Phase 1 74103-06-3, 66635-83-4 3826
5
Metoclopramide Approved, Investigational Phase 4,Phase 3,Phase 2 364-62-5 4168
6
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 99-66-1 3121
7
Milnacipran Approved Phase 4 92623-85-3 65833
8
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757 53477783
9
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
10
Timolol Approved Phase 4 26839-75-8 33624 5478
11
Sumatriptan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103628-46-2 5358
12
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
13
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
14
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
15
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1 97240-79-4 5284627
16
Prochlorperazine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1984-02-6, 58-38-8 4917
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
18
Salmon Calcitonin Approved, Investigational Phase 4,Phase 1 47931-85-1 16129616
19
Histamine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 75614-87-8, 51-45-6 774
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
21
Dihydroergotamine Approved Phase 4,Phase 3,Phase 1 6190-39-2, 511-12-6 10531
22
Amitriptyline Approved Phase 4,Phase 3 50-48-6 2160
23
Perphenazine Approved Phase 4,Phase 3 58-39-9 4748
24
Zonisamide Approved, Investigational Phase 4,Phase 2 68291-97-4 5734
25
Ergotamine Approved Phase 4,Phase 3 113-15-5 8223
26
Nortriptyline Approved Phase 4 72-69-5 4543
27
Nadolol Approved Phase 4,Phase 1 42200-33-9 39147
28
Rizatriptan Approved Phase 4,Phase 3,Phase 2,Phase 1 145202-66-0, 144034-80-0 5078
29
Frovatriptan Approved, Investigational Phase 4,Phase 3,Phase 2 158747-02-5 77992
30
Diphenhydramine Approved Phase 4,Phase 2,Phase 3 58-73-1, 147-24-0 3100
31
Promethazine Approved Phase 4,Phase 2,Phase 3 60-87-7 4927
32
Almotriptan Approved, Investigational Phase 4,Phase 3 154323-57-6, 181183-52-8 123606
33
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 1
34
Eletriptan Approved, Investigational Phase 4,Phase 3,Phase 2 143322-58-1 77993
35
Naratriptan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 143388-64-1, 121679-13-8 4440
36
Zolmitriptan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 139264-17-8 441240 60857
37
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
38
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
39
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
40
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
41
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
42
Dinoprostone Approved Phase 4,Phase 1,Phase 2 363-24-6 5280360
43
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
44
Flunarizine Approved Phase 4,Phase 1 52468-60-7 941361
45
Norepinephrine Approved Phase 4 51-41-2 439260
46
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
47
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
48
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
49
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
50
Ephedrine Approved Phase 4 299-42-3 9294

Interventional clinical trials:

(show top 50) (show all 837)
id Name Status NCT ID Phase
1 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
2 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
3 Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Unknown status NCT00799045 Phase 4
4 A Randomized Trial of Valproate Versus Ketorolac Versus Metoclopramide for Acute Migraine Unknown status NCT01267864 Phase 4
5 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4
6 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4
7 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4
8 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4
9 Cupping and Serkangabin Versus Conventional Migraine Treatment Completed NCT01476930 Phase 4
10 "Completeness of Response" Following Treatment With Treximet™ for Migraine Completed NCT00893737 Phase 4
11 Drug and Non-Drug Treatment Of Severe Migraine Completed NCT00910689 Phase 4
12 Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine Completed NCT00846495 Phase 4
13 Ictal and Interictal Inflammatory Markers in Migraine Completed NCT01138150 Phase 4
14 An Efficacy and Tolerability Study of Topiramate in Participants With Migraine Completed NCT01060111 Phase 4
15 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4
16 A Randomized, Placebo-Controlled, Double-blind Study of Tianshu Capsule in the Treatment of Migraine. Completed NCT02035111 Phase 4
17 Two Rizatriptan Prescribing Portions for Treatment of Migraine Completed NCT00397254 Phase 4
18 The Effectiveness of Almotriptan Malate (AXERT®) 12.5 Milligrams When Taken at the Onset of Migraine Pain Completed NCT00212823 Phase 4
19 Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine Completed NCT00904098 Phase 4
20 Migraine Treatment Satisfaction With Treximet Versus Concomitant 2 Aleve and Imitrex Completed NCT01450995 Phase 4
21 Trial of Comprehensive Migraine Intervention Completed NCT01071317 Phase 4
22 Effect of Acetyl-L-carnitine in Migraine Completed NCT01695317 Phase 4
23 Treximet Trademark (TM) in the Prevention and Modification of Disease Progression in Migraine Completed NCT01300546 Phase 4
24 Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? Completed NCT01086358 Phase 4
25 Treximet in the Treatment of Chronic Migraine Completed NCT01090050 Phase 4
26 A Clinical Trial Comparing Two Different Medications to Determine Which One is Better for Patients With an Acute Migraines in the Emergency Department Completed NCT00364806 Phase 4
27 Greater Occipital Nerve Block for Migraine Prophylaxis Completed NCT00915473 Phase 4
28 A Trial to Study of the Effects of Eletriptan 40mg on Mild vs Moderate to Severe Pain Intensity of Migraine Completed NCT00174395 Phase 4
29 Intravenous Metoclopramide in the Acute Treatment of Migraine: A Double-blind, Randomized, Placebo-controlled Trial Completed NCT02314351 Phase 4
30 Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. Completed NCT00212810 Phase 4
31 Evaluation of Treatment Satisfaction and Preference for Sumavel DosePro in the Treatment of Migraine Completed NCT01016834 Phase 4
32 Oral Dexamethasone for Treatment of Migraine Completed NCT00216736 Phase 4
33 CGRP, Estrogen, Cortisol, VIP, α-Amylase, PGE2, PGI2 and ß-Endorphin Levels in Menstrual Migraine Before and After Treximet Completed NCT01329562 Phase 4
34 Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis Completed NCT02639598 Phase 4
35 A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine Headache Completed NCT00210509 Phase 4
36 A Research Study Examining The Use Of Duloxetine In The Prevention Of Migraine Headache Completed NCT00443352 Phase 4
37 A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period Completed NCT00792636 Phase 4
38 Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine Completed NCT00210496 Phase 4
39 The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache Completed NCT00719134 Phase 4
40 Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine Completed NCT01248468 Phase 4
41 Pharmacokinetics & Safety of Cambia® in Migraine With or Without Aura in 12-17 Year Olds Completed NCT02287376 Phase 4
42 Safety and Efficacy of Eletriptan for the Treatment of Migraine in Subjects Unsuccessfully Treated With Nonsteroidal Anti-inflammatory Drugs Completed NCT00634985 Phase 4
43 A Study of Prophylaxis for Migraine Patients With Topiramate in India Completed NCT01836874 Phase 4
44 Diphenhydramine for Acute Migraine Completed NCT01825941 Phase 4
45 Efficacy and Safety of Eletriptan for the Treatment of Migraine in Patients Not Satisfied With Rizatriptan Therapy Completed NCT00632385 Phase 4
46 Clinical Study Of Migraine Evolution Completed NCT00460005 Phase 4
47 Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes. Completed NCT02436499 Phase 4
48 An Observational Study of BOTOX® as Headache Prophylaxis for Chronic Migraine Completed NCT01686581 Phase 4
49 Comparison of Ketorolac Nasal Spray to Sumatriptan Nasal Spray and Placebo for Acute Treatment of Migraine Completed NCT01807234 Phase 4
50 Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine Completed NCT01709708 Phase 4

Search NIH Clinical Center for Migraine with or Without Aura 1

Cochrane evidence based reviews: migraine without aura

Genetic Tests for Migraine with or Without Aura 1

Genetic tests related to Migraine with or Without Aura 1:

id Genetic test Affiliating Genes
1 Migraine 29

Anatomical Context for Migraine with or Without Aura 1

MalaCards organs/tissues related to Migraine with or Without Aura 1:

39
Brain

Publications for Migraine with or Without Aura 1

Variations for Migraine with or Without Aura 1

Copy number variations for Migraine with or Without Aura 1 from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39736 10 118956999 118969809 Copy number KCNK18 Migraine

Expression for Migraine with or Without Aura 1

Search GEO for disease gene expression data for Migraine with or Without Aura 1.

Pathways for Migraine with or Without Aura 1

GO Terms for Migraine with or Without Aura 1

Sources for Migraine with or Without Aura 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet