MGR13
MCID: MGR019
MIFTS: 16

Migraine, with or Without Aura 13 (MGR13) malady

Categories: Genetic diseases

Aliases & Classifications for Migraine, with or Without Aura 13

Aliases & Descriptions for Migraine, with or Without Aura 13:

Name: Migraine, with or Without Aura 13 54
Migraine with or Without Aura 13 66 29
Migraine, with or Without Aura, Susceptibility to, 13 13
Mgr13 66

Classifications:



External Ids:

OMIM 54 613656
MedGen 40 C3150908

Summaries for Migraine, with or Without Aura 13

UniProtKB/Swiss-Prot : 66 Migraine with or without aura 13: A form of migraine transmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.

MalaCards based summary : Migraine, with or Without Aura 13, also known as migraine with or without aura 13, is related to migraine with or without aura 1 and migraine with or without aura, susceptibility 13. An important gene associated with Migraine, with or Without Aura 13 is KCNK18 (Potassium Two Pore Domain Channel Subfamily K Member 18). The drugs Dronabinol and Analgesics have been mentioned in the context of this disorder.

Description from OMIM: 613656

Related Diseases for Migraine, with or Without Aura 13

Diseases related to Migraine, with or Without Aura 13 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 10.9
2 migraine with or without aura, susceptibility 13 10.8

Symptoms & Phenotypes for Migraine, with or Without Aura 13

Clinical features from OMIM:

613656

Drugs & Therapeutics for Migraine, with or Without Aura 13

Drugs for Migraine, with or Without Aura 13 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078 2978
2 Analgesics Phase 2
3 Analgesics, Non-Narcotic Phase 2
4 Cannabinoid Receptor Agonists Phase 2
5 Hallucinogens Phase 2
6 Hormone Antagonists Phase 2
7 Hormones Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
9 Neurotransmitter Agents Phase 2
10 Peripheral Nervous System Agents Phase 2
11 Psychotropic Drugs Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 DFN-11 Injection in Episodic Migraine With or Without Aura Active, not recruiting NCT02569853 Phase 3
2 Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache Completed NCT00123201 Phase 2

Search NIH Clinical Center for Migraine, with or Without Aura 13

Genetic Tests for Migraine, with or Without Aura 13

Genetic tests related to Migraine, with or Without Aura 13:

id Genetic test Affiliating Genes
1 Migraine, with or Without Aura 13 29

Anatomical Context for Migraine, with or Without Aura 13

Publications for Migraine, with or Without Aura 13

Variations for Migraine, with or Without Aura 13

ClinVar genetic disease variations for Migraine, with or Without Aura 13:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 KCNK18 NM_181840.1(KCNK18): c.414_415delCT (p.Phe139Trpfs) deletion risk factor rs869025175 GRCh37 Chromosome 10, 118969069: 118969070

Expression for Migraine, with or Without Aura 13

Search GEO for disease gene expression data for Migraine, with or Without Aura 13.

Pathways for Migraine, with or Without Aura 13

GO Terms for Migraine, with or Without Aura 13

Sources for Migraine, with or Without Aura 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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