MCID: MGR001
MIFTS: 52

Migraine Without Aura malady

Summaries for Migraine Without Aura

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards: Migraine Without Aura, also known as common migraine, is related to migraine and panic disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Dopamine receptors. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are nervous system and behavior/neurological.

Description from OMIM:46 157300

Aliases & Classifications for Migraine Without Aura

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

migraine without aura 8 46 10
common migraine 8 44 60
migraine with or without aura 46


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Disease Ontology8 DOID:12783
MeSH34 D020326
ICD9CM27 346.1

Related Diseases for Migraine Without Aura

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17GeneCards, 18GeneDecks
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Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.0DRD5, PNOC, DRD4, DRD3, DRD1, KCNK18
2panic disorder30.3DRD4, TPH2, HTR1A
3bipolar disorder29.9DRD1, HTR1A, DRD3, DRD5, DRD4, TPH2
4migraine with aura11.1
5cerebritis10.5
6migraine with or without aura 110.5
7migraine with or without aura 310.5
8migraine, with or without aura 1210.5
9migraine, with or without aura 1310.5
10migraine with or without aura 510.5
11neuronitis10.4
12migraine without aura 410.4
13stroke, ischemic10.2
14neurofibromatosis10.2
15parametritis10.2
16patent foramen ovale10.2
17alexithymia10.2
18duodenitis10.2
19endometriosis10.2
20pertussis10.2
21nicotine dependence10.0DRD4
22cocaine dependence10.0DRD3
23dementia10.0HTR1A
24multiple sclerosis10.0TNF
25spinocerebellar ataxia type 310.0HTR1A
26prion disease10.0ENO2
27delusional disorder10.0DRD4
28substance abuse10.0DRD3, DRD4
29neuroblastoma10.0ENO2
30alcohol dependence10.0DRD4, DRD1
31anorexia nervosa10.0HTR1A, DRD4
32anxiety disorder10.0TPH2
33fibromyalgia10.0PNOC
34epulis10.0ENO2
35ischemia10.0HTR1A, PNOC
36ganglioneuroblastoma10.0S100B, ENO2
37pathological gambling10.0DRD1, DRD3, DRD4
38astrocytoma10.0S100B, INA
39endogenous depression10.0DRD3, HTR1A
40drug dependence10.0PNOC, DRD3
41ganglioglioma10.0S100B, ENO2
42merkel cell carcinoma10.0ENO2
43substance dependence10.0DRD3, DRD4, DRD5
44sudden infant death syndrome10.0HTR1A
45personality disorder10.0TPH2, DRD4, DRD3
46schizoaffective disorder10.0DRD4, DRD3
47olfactory neuroblastoma10.0ENO2, S100B
48chronic fatigue syndrome10.0HTR1A
49prostate small cell carcinoma10.0INA
50gilles de la tourette syndrome10.0HTR1A, DRD4, DRD3, DRD1

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Clinical Features for Migraine Without Aura

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46OMIM
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Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Migraine Without Aura

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Anatomical Context for Migraine Without Aura

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32MalaCards
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MalaCards organs/tissues related to Migraine Without Aura:

32
Brain, Cortex, Monocytes, Heart, Occipital lobe

Animal Models for Migraine Without Aura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Migraine Without Aura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.4TNF, HTR1A, DRD1, DRD3, DRD4, DRD5
2MP:00053869.1TPH2, S100B, TNF, HTR1A, DRD1, DRD3

Publications for Migraine Without Aura

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50PubMed
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Articles related to Migraine Without Aura:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Executive dysfunctions in migraine with and without aura: what is the role of white matter lesions? (23808818)
2014
2
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
3
Disrupted default mode network connectivity in migraine without aura. (24207164)
2013
4
A case of migraine without aura that was successfully treated with an herbal medicine. (23758551)
2013
5
White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study. (23447382)
2013
6
Brief migraine episodes in children and adolescents-a modification to International Headache Society pediatric migraine (without aura) diagnostic criteria. (23526480)
2013
7
Heart rate variability in sleep-related migraine without aura. (23853566)
2013
8
Dynamic changes in thalamic microstructure of migraine without aura patients: a diffusion tensor magnetic resonance imaging study. (24200371)
2013
9
Effect of pain on the timing pattern of masseter muscle activity during the open-close-clench cycle in the migraine without aura and tension type headaches. (24250884)
2012
10
Detection of possible factors favouring the evolution of migraine without aura into chronic migraine. (22644195)
2012
11
A case of strictly unilateral migraine without aura transformed in an episodic hemicrania continua. (20924631)
2011
12
Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration? (21293918)
2011
13
Bronchial hyper-reactivity in migraine without aura: is it a new clue for inflammation? (21352216)
2011
14
Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study. (21816769)
2011
15
Combined oral contraceptives in women with menstrual migraine without aura. (21843889)
2011
16
Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura. (20740293)
2010
17
Plasma homocysteine in patients of migraine without aura. (21702266)
2010
18
Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study. (19614704)
2010
19
Response to Ayurvedic therapy in the treatment of migraine without aura. (20532095)
2010
20
Posterior cerebral hypoperfusion in migraine without aura. (18513260)
2008
21
Migraine without aura: comparison with cervicogenic headache. VAYgAY study of headache epidemiology. (18031560)
2008
22
Reversible imaging abnormalities consistent with CSD during migraine without aura attack. (18819183)
2008
23
Seizures with prolonged EEG abnormalities during an attack of migraine without aura. (17578546)
2007
24
Inhibition of the nociceptive R2 blink reflex after supraorbital or index finger stimulation is normal in migraine without aura between attacks. (17598762)
2007
25
A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura. (17474108)
2007
26
Current views of the risk of stroke for migraine with and migraine without aura. (18778576)
2006
27
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. (15182958)
2004
28
Monozygotic twin sisters suffering from cluster headache and migraine without aura. (12796556)
2003
29
Central 5-HT receptor hypersensitivity in migraine without aura. (12534577)
2003
30
Transient visual disturbances during migraine without aura attacks. (12390623)
2002
31
Comparison of cortical excitability in chronic migraine (transformed migraine) and migraine without aura. A transcranial magnetic stimulation study. (12242552)
2002
32
Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study. (12110110)
2002
33
Acupuncture in the prophylactic treatment of migraine without aura: a comparison with flunarizine. (12390610)
2002
34
Contingent negative variation in subjects at risk for migraine without aura. (11690729)
2001
35
Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura. (10825576)
2000
36
Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura. (10765051)
2000
37
Chiropractic management of migraine without aura. A case study. (17987195)
1999
38
Weekend headache: a retrospective study in migraine without aura and episodic tension-type headache. (15613189)
1999
39
The relative role of genetic and environmental factors in migraine without aura. (10496258)
1999
40
Propranolol vs flunarizine vs flunarizine plus propranolol in migraine without aura prophylaxis. A double-blind trial. (9629401)
1997
41
Cerebrovascular CO2 reactivity in migraine with aura and without aura. A transcranial Doppler study. (7484067)
1995
42
Migraine with aura and migraine without aura: one entity, two, or more? (7553805)
1995
43
Intranasal capsaicin for acute abortive treatment of migraine without aura. (7775192)
1995
44
Sex-hormone-related events in migrainous females. A clinical comparative study between migraine with aura and migraine without aura. (7641250)
1995
45
Intracellular and plasma magnesium in familial hemiplegic migraine and migraine with and without aura. (8200020)
1994
46
Immunocyte enumeration in duodenal biopsies of migraine without aura patients with or without food-induced migraine. (7828196)
1994
47
In vivo administration of propranolol decreases exaggerated amounts of serum TNF-alpha in patients with migraine without aura. Possible mechanism of action. (1293974)
1992
48
Autonomic nervous system function in migraine without aura. (1774161)
1991
49
The similarities and differences of migraine with aura and migraine without aura: a preliminary study. (1742774)
1991
50
Genetic transmission of migraine without aura: a study of 68 families. (1783537)
1991

Genetic Variations for Migraine Without Aura

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Expression for genes affiliated with Migraine Without Aura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

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Pathways for genes affiliated with Migraine Without Aura

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Migraine Without Aura

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1cis flupentixol2810.6DRD3, DRD5, DRD1
2eticlopride28 4411.6DRD3, DRD1, DRD4
3nemonapride49 44 2812.5HTR1A, DRD3, DRD4
4sch 233904410.5DRD3, DRD1, DRD4
5piribedil28 4411.5DRD4, DRD3, HTR1A
6raclopride44 2811.5DRD4, HTR1A, DRD1, DRD3
7roxindole28 4411.5HTR1A, DRD3, DRD4
8Methotrimeprazine1110.5DRD5, DRD1, DRD3, DRD4
9paliperidone44 1111.5DRD4, DRD3, DRD1, HTR1A
10iloperidone49 44 28 1113.5DRD3, DRD1, HTR1A, DRD4
11asenapine28 1111.5DRD1, DRD3, DRD4, HTR1A
12terguride28 4411.5DRD3, DRD4, HTR1A
13fluphenazine28 44 1112.5DRD1, DRD5, DRD4
14(+)-butaclamol28 4411.4DRD5, HTR1A, DRD1, DRD3, DRD4
15rotigotine44 28 1112.4DRD4, DRD1, DRD3, DRD5, HTR1A
16spiperone28 4411.4DRD4, DRD3, HTR1A, DRD5, DRD1
17ropinirole44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
18lisuride28 44 1112.4DRD3, DRD4, HTR1A, DRD1, DRD5
19piperazine44 1111.4DRD4, DRD3, HTR1A
20pergolide28 44 1112.4DRD1, HTR1A, DRD4, DRD5, DRD3
21pramipexole44 49 28 1113.4DRD5, DRD4, DRD3, DRD1, HTR1A
22cabergoline28 44 1112.4DRD4, HTR1A, DRD1, DRD5, DRD3
235-ht2810.4HTR1A, DRD5, DRD1
24aripiprazole28 49 44 11 2414.4DRD4, DRD3, DRD1, HTR1A, DRD5
25ziprasidone49 28 44 1113.4DRD4, DRD3, DRD5, HTR1A, DRD1
26apomorphine44 28 1112.4DRD1, DRD3, HTR1A, DRD4, DRD5
27quetiapine44 49 28 11 2414.4DRD1, DRD3, DRD4, DRD5, HTR1A
28risperidone28 44 49 59 11 2415.4DRD4, DRD1, DRD3, HTR1A
29chlorpromazine44 28 49 1113.4DRD4, DRD3, DRD5, DRD1, HTR1A
30bromocriptine28 44 1112.4HTR1A, DRD5, DRD4, DRD3, DRD1
31olanzapine49 44 28 11 2414.4DRD3, DRD4, DRD5, DRD1, HTR1A
32sulpiride44 28 1112.4DRD1, DRD4, DRD3
33methylphenidate44 49 1112.4DRD1, DRD4, DRD5
34levodopa44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
35clozapine44 28 49 1113.4DRD3, DRD5, DRD4, DRD1, HTR1A
36haloperidol44 28 2 49 1114.4DRD5, DRD4, DRD3, DRD1, HTR1A
37maoa4410.3TPH2, HTR1A, DRD4
38cocaine44 1111.3DRD3, DRD1, S100B, DRD4, PNOC
39catecholamine4410.3DRD3, S100B, DRD1, DRD4, DRD5, ENO2
40thioridazine28 44 49 1113.3DRD5, DRD1, HTR1A
41opiate4410.2DRD3, INA, DRD1, PNOC
42quinpirole44 2811.2DRD4, DRD3, DRD1
435-hydroxytryptamine4410.2TPH2, ENO2, PNOC, DRD4, HTR1A
44ketanserin28 4411.2HTR1A, DRD5
45potassium44 11 2412.1KCNK18, S100B, DRD3, PNOC, ENO2, DRD4
46norepinephrine44 11 2412.0DRD4, DRD1, PNOC, HTR1A, S100B, DRD3
47dopamine44 28 11 2413.0ENO2, DRD1, S100B, DRD5, DRD4, PNOC
48gaba4410.0S100B, DRD1, ENO2, DRD4, PNOC
49adenylate449.8DRD4, ENO2, PNOC, DRD1, S100B, HTR1A
50calcium44 49 11 2412.0MMP17, PNOC, DRD3, DRD1, S100B, DRD4

GO Terms for genes affiliated with Migraine Without Aura

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16Gene Ontology
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Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7MMP17, DRD5, DRD4, DRD3, DRD1, HTR1A

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.6DRD5, DRD1
2response to histamineGO:03477610.5DRD3, DRD4
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.5DRD3, DRD1
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD3
5dopamine metabolic processGO:04241710.5DRD1, DRD3, DRD4
6regulation of dopamine metabolic processGO:04205310.5DRD4, DRD1, HTR1A
7adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3, DRD5
8cellular response to catecholamine stimulusGO:07187010.5DRD1, DRD5
9behavioral response to cocaineGO:04814810.5DRD4, DRD3, DRD1
10positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5DRD5, DRD1
11behavioral fear responseGO:00166210.5HTR1A, DRD1, DRD4
12synaptic transmission, dopaminergicGO:00196310.4DRD5, DRD4, DRD3, DRD1
13response to amphetamineGO:00197510.4DRD1, DRD3, DRD4, DRD5
14phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD1, DRD5
15response to glucocorticoid stimulusGO:05138410.3TPH2, TNF, S100B
16long term synaptic depressionGO:06029210.3DRD5, DRD1
17arachidonic acid secretionGO:05048210.3DRD4, DRD3
18cellular calcium ion homeostasisGO:00687410.3DRD5, DRD4, DRD3
19negative regulation of protein secretionGO:05070910.2DRD3, DRD4
20prepulse inhibitionGO:06013410.0DRD3, DRD1

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3
2dopamine bindingGO:03524010.1DRD5, DRD4, DRD3, DRD1
3dopamine neurotransmitter receptor activityGO:00495210.1DRD1, DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.0DRD5, DRD1

Products for genes affiliated with Migraine Without Aura

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Sources for Migraine Without Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet