MCID: MGR001
MIFTS: 55

Migraine Without Aura malady

Neuronal diseases category

Summaries for Migraine Without Aura

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9Disease Ontology, 48OMIM, 34MalaCards
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Disease Ontology:9 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards: Migraine Without Aura, also known as common migraine, is related to migraine and panic disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Hypothetical Network for Drug Addiction and Monoamine Transport. The compounds skf 81297 hydrobromide and sch 23390 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are vision/eye and adipose tissue.

Description from OMIM:48 157300

Aliases & Classifications for Migraine Without Aura

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9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

migraine without aura 9 48 11
common migraine 9 46 63
migraine with or without aura 48


External Ids:

Disease Ontology9 DOID:12783
MeSH36 D020326
ICD9CM28 346.1

Related Diseases for Migraine Without Aura

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18GeneCards, 19GeneDecks
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Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.8DRD3, HTR1A, EDNRA, DRD4, DRD5, DRD1
2panic disorder30.3HTR1A, DRD4, TPH2
3bipolar disorder29.8DRD3, DRD4, DRD1, HTR1A, TPH2, DRD5
4migraine with aura10.9
5headache10.9
6blindness10.7
7cerebritis10.5
8migraine with or without aura 110.5
9migraine with or without aura 310.5
10migraine, with or without aura 1210.5
11migraine, with or without aura 1310.5
12migraine with or without aura 510.5
13neuronitis10.4
14cluster headache10.4
15migraine without aura 410.4
16neurofibromatosis10.2
17parametritis10.2
18alexithymia10.2
19duodenitis10.2
20patent foramen ovale10.2
21endometriosis10.2
22pertussis10.2
23hemicrania continua10.2
24hypersomnia10.2
25delusional disorder10.1DRD4
26nicotine dependence10.1DRD4
27alcohol dependence10.1DRD1, DRD4
28substance abuse10.1DRD3, DRD4
29conduct disorder10.1DRD4, DRD5
30drug addiction10.0DRD3, DRD1
31endogenous depression10.0DRD3, HTR1A
32schizoaffective disorder10.0DRD4, DRD3
33gilles de la tourette syndrome10.0DRD4, DRD5
34seasonal affective disorder10.0DRD4, HTR1A
35pathological gambling10.0DRD1, DRD3, DRD4
36substance dependence10.0DRD5, DRD4, DRD3
37toxic shock syndrome10.0TNF, EDNRA
38memory impairment10.0DRD1, HTR1A
39personality disorder10.0TPH2, DRD4, DRD3
40anxiety disorder10.0TPH2, HTR1A
41familial hemiplegic migraine10.0
42carotidynia10.0
43hemiplegic migraine10.0
44essential hypertension10.0DRD5, EDNRA, DRD1
45anorexia nervosa10.0DRD4, HTR1A
46attention deficit hyperactivity disorder10.0DRD4, DRD5, TPH2, DRD1
47parkinson's disease10.0DRD1, HTR1A, DRD3, DRD4
48alzheimer's disease9.9HTR1A, DRD3, DRD1, DRD4
49viral infectious disease9.9EDNRA, TNF, HTR1A
50obesity9.9EDNRA, HTR1A, DRD4, TNF

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Symptoms for Migraine Without Aura

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48OMIM
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Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Migraine Without Aura

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Anatomical Context for Migraine Without Aura

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34MalaCards
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MalaCards organs/tissues related to Migraine Without Aura:

34
Brain, Cortex, Monocytes, Heart, Occipital lobe

Animal Models for Migraine Without Aura or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Migraine Without Aura:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9DRD1, DRD5, DRD4, TNF
2MP:00053758.5TNF, TPH2, DRD3, DRD1
3MP:00053818.5EDNRA, TNF, DRD3, DRD1
4MP:00053888.3DRD1, TPH2, TNF, EDNRA
5MP:00053867.4TNF, TPH2, HTR1A, DRD4, DRD3, DRD1
6MP:00107687.3EDNRA, TNF, TPH2, HTR1A, DRD3, DRD1
7MP:00053857.1EDNRA, TNF, TPH2, HTR1A, DRD5, DRD3
8MP:00053766.9EDNRA, TNF, TPH2, HTR1A, DRD4, DRD3
9MP:00036316.6DRD1, EDNRA, TNF, TPH2, HTR1A, DRD4

Publications for Migraine Without Aura

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53PubMed
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Articles related to Migraine Without Aura:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
2
Disrupted default mode network connectivity in migraine without aura. (24207164)
2013
3
Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. (24134520)
2013
4
Self-concept evaluation and migraine without aura in childhood. (23950647)
2013
5
Fatigue is increased in episodic migraine without aura patients. (23865916)
2013
6
A case of migraine without aura that was successfully treated with an herbal medicine. (23758551)
2013
7
A Japanese SUNA patient with migraine without aura and medication overuse headache responsive to topiramate. (24097323)
2013
8
Abnormal sensorimotor plasticity in migraine without aura patients. (23693159)
2013
9
I+-[11C] methyl-L tryptophan-PET as a surrogate for interictal cerebral serotonin synthesis in migraine without aura. (24057438)
2013
10
Hypersomnia in children affected by migraine without aura: a questionnaire-based case-control study. (23459616)
2013
11
Sublingual piroxicam in migraine without aura. (21887905)
2011
12
31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. (21289000)
2011
13
A case of strictly unilateral migraine without aura transformed in an episodic hemicrania continua. (20924631)
2011
14
Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration? (21293918)
2011
15
Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation. (21533737)
2011
16
Turn down the lights!: an irritable occipital cortex in migraine without aura. (21148117)
2011
17
Posterior hypoperfusion in migraine without aura? (20656715)
2010
18
Posterior cerebral hypoperfusion in migraine without aura. (18513260)
2008
19
Migraine without aura: comparison with cervicogenic headache. VAYgAY study of headache epidemiology. (18031560)
2008
20
Reversible imaging abnormalities consistent with CSD during migraine without aura attack. (18819183)
2008
21
Stereotyped topography of different elevated contingent negative variation components in children with migraine without aura points towards a subcortical dysfunction. (17027155)
2007
22
Seizures with prolonged EEG abnormalities during an attack of migraine without aura. (17578546)
2007
23
Serotonin transporter protein polymorphism and harm avoidance personality in migraine without aura. (16732845)
2006
24
Diagnostic criteria of pediatric migraine without aura. (16562783)
2006
25
Sleep quality, chronotypes and preferential timing of attacks in migraine without aura. (16362680)
2005
26
Plasma nociceptin levels are reduced in migraine without aura. (15773823)
2005
27
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. (15182958)
2004
28
Monozygotic twin sisters suffering from cluster headache and migraine without aura. (12796556)
2003
29
A locus for migraine without aura maps on chromosome 14q21.2-q22.3. (12474141)
2003
30
Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. (12047331)
2002
31
Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura. (12100091)
2002
32
Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. (12390611)
2002
33
Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. (11328331)
2001
34
Chiropractic management of migraine without aura. A case study. (17987195)
1999
35
Migraine without aura: a population-based twin study. (10514097)
1999
36
Weekend headache: a retrospective study in migraine without aura and episodic tension-type headache. (15613189)
1999
37
The relative role of genetic and environmental factors in migraine without aura. (10496258)
1999
38
Coexistence of cervicogenic headache and migraine without aura (?). (10713894)
1999
39
High-density assessment of the IHS classification criteria for migraine without aura: a prospective study. (10376163)
1999
40
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
41
QEEG in migraine without aura. (9731930)
1998
42
Migraine without aura and ACE-gene deletion polymorphism: is there a correlation? Preliminary findings. (9358966)
1997
43
A study of symptomatic drug use in migraine without aura. (8749703)
1995
44
Cognitive functions in migraine without aura between attacks: a psychophysiological approach using the "oddball" paradigm. (7746225)
1995
45
Thresholds for detection of a target against a background grating suggest visual dysfunction in migraine with aura but not migraine without aura. (7641245)
1995
46
The frontotemporal region plays a role in the genesis of migraine without aura. (7721576)
1995
47
Leukocyte subsets and cortisol serum levels in patients with migraine without aura and chronic tension-type headache. (8062352)
1994
48
Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. (8376100)
1993
49
Migraine without aura and ischemic stroke. (1517072)
1992
50
Autonomic nervous system function in migraine without aura. (1774161)
1991

Variations for Migraine Without Aura

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Expression for genes affiliated with Migraine Without Aura

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

Search GEO for disease gene expression data for Migraine Without Aura.

Pathways for genes affiliated with Migraine Without Aura

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB, 54QIAGEN, 56Reactome
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Pathways related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DRD1, DRD4
2
Show member pathways
Serotonin Transporter Activity39
9.3TPH2, TNF
39.2DRD1, DRD5, EDNRA
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.1DRD1, DRD3, DRD4
59.0TPH2, HTR1A
69.0DRD3, DRD4, EDNRA
78.7DRD4, DRD5, DRD3, DRD1
8
Show member pathways
8.7DRD4, DRD5, DRD3, DRD1
98.7TNF, TPH2, HTR1A
10
Show member pathways
8.1DRD1, DRD3, DRD5, DRD4, HTR1A
11
Show member pathways
7.6EDNRA, HTR1A, DRD4, DRD5, DRD3, DRD1
12
Show member pathways
7.6EDNRA, HTR1A, DRD4, DRD5, DRD3, DRD1
13
Show member pathways
7.3TPH2, HTR1A, DRD4, DRD5, DRD3, DRD1

Compounds for genes affiliated with Migraine Without Aura

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1skf 81297 hydrobromide629.8DRD5, DRD1
2sch 23390 hydrochloride629.8DRD1, DRD5
3sch 39166 hydrobromide629.7DRD5, DRD1
4skf-76783309.7DRD1, DRD5
5cis flupentixol309.6DRD5, DRD1, DRD3
6skf 38393 hydrobromide629.6DRD1, DRD5
7fluphenazine30 46 52 1212.5DRD4, DRD5, DRD1
8eticlopride46 3010.5DRD1, DRD3, DRD4
9methylphenidate46 52 1211.5DRD5, DRD1, DRD4
10sch 23390469.4DRD4, DRD3, DRD1
11skf 83959 hydrobromide629.4DRD1, DRD5
125-ht309.4HTR1A, DRD1, DRD5
13sulpiride46 30 1211.4DRD4, DRD3, DRD1
14thioridazine30 46 52 1212.3DRD5, HTR1A, DRD1
15ketanserin46 3010.3DRD1, DRD5, HTR1A
16quinpirole46 3010.3DRD4, DRD1, DRD3
17nemonapride46 52 3011.2DRD3, HTR1A, DRD4
18piribedil30 4610.2DRD4, HTR1A, DRD3
19roxindole30 4610.2HTR1A, DRD3, DRD4
20terguride46 3010.2DRD4, HTR1A, DRD3
21piperazine46 1210.2DRD3, DRD4, HTR1A
22paroxetine46 52 30 1212.0DRD4, DRD3, HTR1A
23catecholamine469.0DRD5, DRD3, DRD1, DRD4
24raclopride46 309.9DRD3, DRD4, HTR1A, DRD1
25paliperidone46 129.9DRD1, DRD3, HTR1A, DRD4
26iloperidone52 46 30 1211.9HTR1A, DRD4, DRD3, DRD1
27asenapine30 129.8HTR1A, DRD4, DRD1, DRD3
28risperidone46 52 30 62 25 1213.8HTR1A, DRD3, DRD4, DRD1
29maoa468.8DRD4, HTR1A, TPH2
30(+)-butaclamol46 309.5DRD3, DRD1, DRD5, DRD4, HTR1A
31rotigotine30 46 1210.5DRD5, DRD1, DRD4, DRD3, HTR1A
32spiperone46 309.5HTR1A, DRD1, DRD3, DRD4, DRD5
33ropinirole46 129.5HTR1A, DRD3, DRD5, DRD4, DRD1
34lisuride46 30 1210.5DRD3, DRD4, DRD5, DRD1, HTR1A
35pergolide46 30 1210.5DRD5, DRD1, DRD3, DRD4, HTR1A
36pramipexole46 30 52 1211.5DRD1, DRD5, DRD4, HTR1A, DRD3
37cabergoline46 30 1210.5DRD3, DRD5, DRD4, DRD1, HTR1A
38aripiprazole30 46 52 25 1212.5DRD1, DRD4, DRD3, DRD5, HTR1A
39ziprasidone30 52 46 1211.5DRD1, HTR1A, DRD4, DRD5, DRD3
40apomorphine30 46 1210.5HTR1A, DRD1, DRD3, DRD5, DRD4
41quetiapine46 52 30 25 1212.5DRD5, DRD4, DRD3, HTR1A, DRD1
42bromocriptine46 30 1210.5DRD3, HTR1A, DRD4, DRD5, DRD1
43chlorpromazine30 46 52 1211.5DRD1, HTR1A, DRD4, DRD5, DRD3
44olanzapine46 52 30 25 1212.5DRD4, DRD5, HTR1A, DRD1, DRD3
45levodopa46 129.5DRD5, DRD4, DRD3, DRD1, HTR1A
46clozapine46 30 52 1211.5DRD1, DRD3, HTR1A, DRD5, DRD4
47haloperidol46 52 30 3 1212.5HTR1A, DRD1, DRD4, DRD3, DRD5
48cyclic amp46 259.4DRD3, EDNRA, DRD5, DRD4, DRD1
49norepinephrine46 25 1210.0DRD5, DRD1, DRD4, EDNRA, HTR1A, DRD3
50dopamine46 30 25 1210.9DRD3, DRD1, DRD4, DRD5, HTR1A, EDNRA

GO Terms for genes affiliated with Migraine Without Aura

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17Gene Ontology
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Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.2TNF, HTR1A, DRD4, DRD5, DRD3, DRD1
2integral component of plasma membraneGO:0058876.9DRD1, EDNRA, TNF, HTR1A, DRD4, DRD5

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.1DRD5, DRD1
2cellular response to catecholamine stimulusGO:07187010.1DRD1, DRD5
3positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.1DRD5, DRD1
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.1DRD1, DRD5
5long term synaptic depressionGO:06029210.0DRD5, DRD1
6regulation of dopamine uptake involved in synaptic transmissionGO:05158410.0DRD1, DRD3
7transmission of nerve impulseGO:01922610.0DRD1, DRD5
8prepulse inhibitionGO:06013410.0DRD1, DRD3
9positive regulation of mitosisGO:0458409.9DRD3, TNF
10response to cocaineGO:0422209.9DRD5, DRD3
11response to histamineGO:0347769.9DRD3, DRD4
12negative regulation of blood pressureGO:0457769.9DRD5, DRD3
13adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.9DRD3, DRD4
14positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:0514829.9EDNRA, DRD1
15negative regulation of protein secretionGO:0507099.9DRD4, DRD3
16positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8DRD1, EDNRA
17arachidonic acid secretionGO:0504829.8DRD4, DRD3
18adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8DRD5, DRD1
19negative regulation of cAMP biosynthetic processGO:0308189.8EDNRA, DRD4
20response to morphineGO:0432789.8EDNRA, DRD3
21negative regulation of adenylate cyclase activityGO:0071949.8DRD3, DRD4
22adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.6DRD5, DRD3, DRD1
23vasoconstrictionGO:0423109.6EDNRA, HTR1A
24visual learningGO:0085429.6DRD1, DRD3
25activation of adenylate cyclase activityGO:0071909.6DRD1, DRD5, EDNRA
26social behaviorGO:0351769.6DRD3, DRD4
27response to activityGO:0148239.5TPH2, TNF
28cellular calcium ion homeostasisGO:0068749.5DRD4, DRD5, DRD3
29dopamine metabolic processGO:0424179.5DRD4, DRD3, DRD1
30behavioral response to cocaineGO:0481489.5DRD1, DRD3, DRD4
31response to drugGO:0424939.5TNF, DRD3, DRD1
32regulation of dopamine metabolic processGO:0420539.3HTR1A, DRD4, DRD1
33response to glucocorticoidGO:0513849.3TPH2, TNF
34behavioral fear responseGO:0016629.3HTR1A, DRD4, DRD1
35synaptic transmission, dopaminergicGO:0019639.1DRD1, DRD3, DRD5, DRD4
36response to amphetamineGO:0019759.1DRD1, DRD3, DRD5, DRD4
37circadian rhythmGO:0076239.0TPH2, DRD4
38G-protein coupled receptor signaling pathwayGO:0071869.0DRD3, HTR1A, EDNRA
39positive regulation of cell proliferationGO:0082848.6DRD3, HTR1A, EDNRA

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:0015889.6DRD1, DRD5
2drug bindingGO:0081449.5DRD3, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.2DRD3, DRD4
4dopamine neurotransmitter receptor activityGO:0049529.2DRD4, DRD5, DRD1
5dopamine bindingGO:0352408.8DRD1, DRD3, DRD5, DRD4

Products for genes affiliated with Migraine Without Aura

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Sources for Migraine Without Aura

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet