Migraine Without Aura malady

Disease Ontology: A migraine that is characterized by migraine headaches that are not accompanied by an aura.⁶

MalaCards: Migraine Without Aura, also known as common migraine, is related to migraine with aura and familial hemiplegic migraine. An important gene associated with Migraine Without Aura is MGR12 (Migraine, with or without aura, susceptibility to, 12), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The compounds egcg and spiperone have been mentioned in the context of this disorder. Affiliated tissues include brain and monocytes, and related mouse phenotypes are taste/olfaction and adipose tissue.

OMIM: 157300

Aliases & Descriptions:

migraine without aura 6 33 common migraine 6 8 32 43

migraine with or without aura 7 33 migraine disorders 43

Diseases related to migraine without aura by text searches and GeneDecks gene sharing:

(show top 50)    (show all 443)

id	Related Disease	Score	Top Affiliating Genes
1	migraine with aura	30.0	KCNK18, MGR5, MA, CACNA1A, DRD2, SLC6A3
2	familial hemiplegic migraine	29.3	MGR, MGR5, CACNA1A
3	hemiplegic migraine	29.3	MGR, MGR5, CACNA1A
4	bipolar disorder	29.2	HTR1A, SLC6A4
5	panic disorder	28.7	HTR1A, TPH2, DRD1, DRD2, DRD3, DRD4
6	neurodegeneration	26.0	LDLR, S100B, GSTP1, ENO2, CCL2, CACNA1A
7	neuronitis	20.4	PAFAH1B1, KCNK18, LDLR, S100B, GSTM1, GSTP1
8	vascular dementia	13.7	MA, TNF
9	septic shock	13.7	MA, TNF
10	cerebral malaria	13.6	MA, TNF
11	delusional disorder	13.5	DRD3, DRD4
12	generalized anxiety disorder	13.5	HTR1A, SLC6A4
13	myoclonus-dystonia	13.4	DRD2, DRD3, DRD4
14	endogenous depression	13.4	HTR1A, DRD3, SLC6A4
15	attention deficit hyperactivity disorder	13.4	DRD4, SLC6A3
16	separation anxiety disorder	13.4	DRD4, SLC6A3
17	lambert-eaton myasthenic syndrome	13.4	ENO2, CACNA1A, TNF
18	novelty seeking personality	13.4	DRD2, DRD4, COMT
19	antisocial personality disorder	13.4	DRD2, DRD4, SLC6A4
20	congenital epulis	13.3	S100B, ENO2
21	meningeal melanocytoma	13.3	S100B, ENO2
22	leptin receptor deficiency	13.3	DRD2, SLC6A3
23	mycobacterium marinum	13.3	IL8, TNF
24	parametritis	13.3	HTR1A, TNF, SLC6A3
25	cryptogenic organizing pneumonia	13.2	IL8, TNF
26	tic disorder	13.2	DRD2, DRD4
27	opiate dependence	13.2	DRD2, DRD3
28	striatonigral degeneration	13.2	DRD1, DRD2, SLC6A3
29	congenital granular cell tumor	13.2	S100B, ENO2
30	bednar's tumor	13.2	S100B, ENO2
31	ganglioneuroblastoma	13.2	S100B, ENO2, HTR1A
32	myoclonus	13.2	HTR1A, DRD2, DRD3, DRD4
33	askin's tumor	13.2	S100B, ENO2
34	diffuse gastric cancer	13.1	GSTM1, GSTP1, GSTT1
35	metachromatic leukodystrophy	13.1	HTR1A, SLC6A3, SLC6A4
36	cardia cancer	13.1	GSTM1, GSTP1, GSTT1
37	schizophreniform disorder	13.1	DRD2, PRL
38	neonatal jaundice	13.1	GSTM1, GSTT1, TNF
39	peripartum cardiomyopathy	13.1	DRD2, PRL
40	exfoliation syndrome	13.1	GSTM1, GSTP1, GSTT1
41	movement disease	13.1	DRD2, DRD3, SLC6A3
42	memory impairment	13.1	HTR1A, DRD1, SLC6A3
43	conduction disease	13.1	DRD4, DRD5, SLC6A3, SLC6A4
44	alcoholic psychosis	13.1	SLC6A3, SLC6A4
45	drug addiction	13.1	DRD1, DRD2, DRD3, SLC6A3
46	alcoholic pancreatitis	13.1	GSTM1, GSTP1, GSTT1
47	spermatocele	13.1	IL8, TNF
48	paralysis	13.1	KCNK18, CACNA1A, DRD2, DRD3, DRD4
49	bladder cancer susceptibility	13.0	GSTM1, GSTP1, GSTT1, TNF
50	hepatic encephalopathy	13.0	S100B, TNF, DRD2

Clinical features from OMIM: 157300

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to migraine without aura:

²²

MGI Mouse Phenotypes related to migraine without aura:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.5	ENO2, TPH2, DRD2, SLC6A3
2	adipose tissue phenotype	MP:0005375	7.9	NOS2, DRD3, DRD2, TNF, TPH2, CCL2
3	growth/size phenotype	MP:0005378	7.3	SLC6A4, SLC6A3, NFKB1, DRD3, DRD2, DRD1
4	integument phenotype	MP:0010771	7.2	SLC6A4, SLC6A3, PRL, PNOC, DRD2, DRD1
5	muscle phenotype	MP:0005369	7.2	SLC6A4, SLC6A3, NFKB1, NOS2, DRD2, DRD1
6	cardiovascular system phenotype	MP:0005385	7.1	DRD3, DRD5, NOS2, COMT, SLC6A4, DRD2
7	nervous system phenotype	MP:0003631	6.7	DRD4, DRD5, COMT, PRL, SLC6A3, SLC6A4
8	homeostasis/metabolism phenotype	MP:0005376	4.7	DRD3, DRD4, NOS2, COMT, NFKB1, PRL
9	behavior/neurological phenotype	MP:0005386	4.2	PAFAH1B1, DRD3, DRD4, PNOC, NOS2, COMT

Articles related to migraine without aura:

(show all 25)

id	Title	Authors	Year	Affiliating Genes
1	Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration? (21293918)	Yilmaz N.... Dora B.	2011	S100B, ENO2
2	Genetic TPH2 variants and the susceptibility for migr aine: association of a TPH2 haplotype with migraine without aura. (20740293)	Jung A.... Marziniak M.	2010	TPH2
3	Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. (17690944)	Karwautz A.... Wober-Bingol C.	2008	SLC6A3
4	Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study. (18727636)	Lothe A.... MauguiA"re F.	2008	HTR1A
5	Family-based analysis of serotonin transporter gene polymorphisms in migraine with and without aura. (17598758)	Karwautz A.F.... Collier D.A.	2007	SLC6A4
6	Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura. (19513339)	Park J.W.... Shin H.E.	2007	COMT
7	A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura. (17474108)	de Sousa S.C.... Wober-Bingol C.	2007	DRD4
8	Serotonin transporter protein polymorphism and harm avoidance personality in migraine without aura. (16732845)	Park J.W.... Lee K.S.	2006	SLC6A4
9	The functional Val158Met variant of the COMT gene is not associated with migraine with or without aura. (16767536)	MAPssner R.... Meyer J.	2006	COMT
10	The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. (17063315)	Mazaheri S.... Rafiei A.	2006	TNF
11	NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks. (16919057)	Sarchielli P.... Calabresi P.	2006	NFKB1, NOS2
12	Plasma nociceptin levels are reduced in migraine without aura. (15773823)	Ertsey C.... Tekes K.	2005	PNOC
13	Chemokine levels in the jugular venous blood of migraine without aura patients during attacks. (15546258)	Sarchielli P.... Gallai V.	2004	IL8, CCL2
14	Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. (15265050)	Sarchielli P.... Gallai V.	2004	PAFAH1B1
15	A locus for migraine without aura maps on chromosome 14q21.2-q22.3. (12474141)	Soragna D.... Mostacciuolo M.L.	2003	MGR4
16	Central 5-HT receptor hypersensitivity in migraine without aura. (12534577)	Cassidy E.M.... O'Keane V.	2003	PRL, HTR1A
17	Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. (12967601)	Stochino M.E.... Severino G.	2003	DRD2, DRD3, DRD1
18	Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. (12873747)	Mochi M.... Montagna P.	2003	LDLR
19	Glutathione S-transferase polymorphisms: susceptibility to migraine without aura. (12736537)	Kusumi M.... Nakashima K.	2003	GSTP1, GSTT1, GSTM1
20	Dopamine receptor genes and migraine with and without aura: an association study. (12047334)	Shepherd A.G.... Griffiths L.R.	2002	DRD3, DRD1, DRD5
21	Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1. (12473779)	Carlsson A.... Holmberg M.	2002	MGR3
22	Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. (11320173)	Terwindt G.M.... Ferrari M.D.	2001	CACNA1A
23	Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)	Ogilvie A.D.... Olesen J.	1998	SLC6A4
24	Association between dopamine receptor genes and migraine without aura in a Sardinian sample. (9748026)	Del Zompo M.... Piccardi M.P.	1998	DRD2, DRD3, DRD4
25	Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)	Ophoff R.A.... Ferrari M.D.	1997	CACNA1A

Genes related to migraine without aura according to GeneCards:

(show all 32)

id	Symbol	Description	Score	GeneCards Section Context
1	MGR12	Migraine, with or without aura, susceptibility to, 12	11.1	Aliases & Descriptions
2	MGR5	Migraine with or without aura, susceptibility to, 5	11.1	Aliases & Descriptions
3	MGR3	Migraine, familial, with or without aura, susceptibility to	11.1	Publications
4	MGR4	Migraine, susceptibility to, 4	11.1	Publications
5	KCNK18	potassium channel, subfamily K, member 18	11.1
6	MA	Migraine with aura, susceptibility to	11.1
7	MGR	Migraine, several forms	11.1
8	TNF	tumor necrosis factor	11.1	Publications
9	DRD5	dopamine receptor D5	11.0	Publications
10	PNOC	prepronociceptin	11.0	Publications
11	DRD1	dopamine receptor D1	11.0	Publications
12	TPH2	tryptophan hydroxylase 2	11.0	Publications
13	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	11.0	Publications
14	DRD4	dopamine receptor D4	11.0	Publications
15	DRD3	dopamine receptor D3	11.0	Publications
16	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11.0	Publications
17	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
18	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
19	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
20	DRD2	dopamine receptor D2	11.0	Publications
21	COMT	catechol-O-methyltransferase	11.0	Publications
22	GSTT1	glutathione S-transferase theta 1	11.0	Publications
23	S100B	S100 calcium binding protein B	11.0	Publications
24	LDLR	low density lipoprotein receptor	11.0	Publications
25	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
26	GSTM1	glutathione S-transferase mu 1	11.0	Publications
27	GSTP1	glutathione S-transferase pi 1	11.0	Publications
28	IL8	interleukin 8	11.0	Publications
29	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
30	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
31	PRL	prolactin	11.0	Publications
32	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0	Publications

Pathways related to migraine without aura according to GeneDecks:

(show all 25)

id	Pathway	Score	Top Affiliating Genes
1	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	10.0	DRD1, DRD2, DRD3, DRD4
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.9	HTR1A, TPH2, SLC6A4
3	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.7	GSTM1, GSTP1, GSTT1
4	CDK5 Pathway36	9.6	DRD5, DRD4, DRD3, DRD2, DRD1, CACNA1A
5	Amine ligand-binding receptors38	9.6	HTR1A, DRD1, DRD2, DRD3, DRD4, DRD5
6	Naphthalene metabolism41	9.6	GSTT1, GSTP1, GSTM1
7	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.6	DRD5, DRD4, DRD3, DRD2, DRD1, CACNA1A
8	Naphthalene metabolism10	9.6	GSTT1, GSTP1, GSTM1
9	Phase II conjugation38	9.6	COMT, GSTP1, GSTM1
10	Amoebiasis20	9.5	NOS2, IL8
11	Glutathione metabolism10	9.4	GSTM1, GSTP1, GSTT1
12	Immune response_MIF-mediated glucocorticoid regulation41	9.1	NFKB1, NOS2, TNF, IL8
13	Immune response MIF-mediated glucocorticoid regulation10	9.1	NFKB1, NOS2, TNF, IL8
14	NOD-like receptor signaling pathway20	9.1	IL8, CCL2, TNF, NFKB1
15	Immune response_MIF in innate immunity response41	9.0	NFKB1, NOS2, TNF, IL8
16	Immune response MIF in innate immunity response10	9.0	NFKB1, NOS2, TNF, IL8
17	Bacterial infections in CF airways41	9.0	NFKB1, NOS2, TNF, IL8
18	Immune response IL-1 signaling pathway10	9.0	NFKB1, NOS2, TNF, IL8
19	Immune response_IL-1 signaling pathway41	9.0	NFKB1, NOS2, TNF, IL8
20	Pertussis20	8.9	NFKB1, NOS2, TNF, IL8
21	Toxoplasmosis20	8.9	LDLR, TNF, NOS2, NFKB1
22	Neuroactive ligand-receptor interaction20	8.8	PRL, DRD5, DRD4, DRD3, DRD2, DRD1
23	MIF Mediated Glucocorticoid Regulation36	8.7	NFKB1, TNF, CCL2, IL8
24	Chagas disease (American trypanosomiasis)20	8.5	NFKB1, NOS2, TNF, CCL2, IL8
25	MIF Regulation of Innate Immune Cells36	8.5	NFKB1, TNF, CCL2, IL8

Compounds related to migraine without aura according to GeneDecks:

(show top 50)    (show all 230)

id	Compound	Score	Top Affiliating Genes
1	egcg32	9.9	LDLR
2	spiperone32	9.8	HTR1A, DRD1, DRD2, DRD4
3	sch 2339032	9.8	DRD1, DRD2, DRD3, DRD4
4	Methotrimeprazine9 9	10.7	DRD2, DRD3, DRD4, DRD5, DRD1
5	rotigotine32 9 9	11.6	DRD5, DRD3, DRD4, DRD2, DRD1, HTR1A
6	piperazine32 9 9	11.5	DRD2, SLC6A3, DRD4, DRD3, HTR1A
7	bromocriptine32 9 9	11.5	HTR1A, DRD3, DRD5, PRL
8	raclopride32 42	10.5	HTR1A, DRD2, DRD3, DRD4, SLC6A3, DRD1
9	haloperidol32 34 9 9	12.4	HTR1A, DRD1, DRD3, SLC6A4, DRD4, SLC6A3
10	ropinirole32 9 9	11.4	DRD4, DRD2, DRD3, HTR1A, DRD1, DRD5
11	amphetamine32 9 9	11.4	SLC6A4, PNOC, DRD4, DRD1, SLC6A3, DRD2
12	6-hydroxydopamine32	9.3	SLC6A3, COMT, DRD4, DRD3, DRD2, DRD1
13	methylphenidate32 9 9	11.3	DRD1, COMT, DRD5, DRD4, DRD2, SLC6A4
14	catecholamine32	9.2	DRD3, COMT, DRD5, S100B, ENO2, DRD1
15	mptp32	9.2	DRD2, DRD3, SLC6A4, SLC6A3, DRD1, COMT
16	glutamate32	9.2	COMT, PNOC, LDLR, CACNA1A, DRD1, DRD2
17	maoa32	9.2	HTR1A, DRD2, SLC6A4, SLC6A3, COMT, TPH2
18	methamphetamine32 9 9	11.2	DRD1, SLC6A4, COMT, DRD3, DRD4, SLC6A3
19	paliperidone32 9 9	10.9	DRD1, DRD2, DRD3, PRL, DRD4, HTR1A
20	imipramine32 34 9 18 9	12.9	DRD1, GSTP1, HTR1A, SLC6A4, DRD3, SLC6A3
21	remoxipride32 9 9	10.9	DRD4, DRD3, DRD2, PRL
22	sulpiride32 9 9	10.9	DRD4, SLC6A3, PRL, DRD2, DRD3, DRD1
23	heroin32 9 9	10.9	DRD2, DRD4, DRD3, CCL2, SLC6A4, SLC6A3
24	lisuride32 9 9	10.8	DRD2, DRD1, HTR1A, PRL, DRD5, DRD4
25	aripiprazole32 34 9 18 9	12.8	DRD2, DRD5, DRD1, DRD3, DRD4, PRL
26	ziprasidone32 9 9	10.8	HTR1A, DRD1, DRD3, DRD4, PRL, DRD2
27	trimipramine32 34 9 9	11.8	PRL, DRD2, HTR1A, DRD1, SLC6A4, SLC6A3
28	paroxetine32 34 9 9	11.7	HTR1A, DRD4, SLC6A4, SLC6A3, COMT, PRL
29	fluoxetine32 34 9 9	11.7	PRL, SLC6A3, SLC6A4, DRD2, TPH2, HTR1A
30	opiate32	8.6	DRD3, SLC6A4, SLC6A3, PRL, PNOC, DRD2
31	pergolide32 9 9	10.6	DRD5, DRD4, DRD3, DRD2, DRD1, HTR1A
32	gaba32 42	9.6	ENO2, DRD1, DRD2, DRD4, PNOC, SLC6A3
33	cabergoline32 9 9	10.6	DRD1, DRD2, DRD3, DRD4, DRD5, COMT
34	clomipramine32 34 9 9	11.6	PRL, HTR1A, GSTP1, SLC6A3, SLC6A4
35	quetiapine32 9 18 9	11.5	DRD5, DRD4, DRD3, DRD1, PRL, DRD2
36	clozapine32 34 9 9	11.4	SLC6A4, SLC6A3, PRL, DRD4, DRD3, DRD2
37	valine32	8.4	COMT, SLC6A3, DRD4, GSTP1, SLC6A4, GSTT1
38	olanzapine32 34 9 18 9	12.3	DRD3, DRD2, DRD1, HTR1A, DRD4, DRD5
39	pramipexole32 9 9	10.3	DRD5, DRD4, DRD3, DRD1, HTR1A, DRD2
40	apomorphine32 9 9	10.2	DRD5, DRD4, DRD3, DRD2, DRD1, COMT
41	risperidone32 34 9 18 9	12.2	SLC6A4, SLC6A3, PRL, COMT, DRD4, DRD2
42	dopamine32 9 18 9	11.0	SLC6A4, DRD1, S100B, SLC6A3, COMT, PNOC
43	acetylcholine32 9 18 9	11.0	SLC6A3, ENO2, PNOC, HTR1A, NOS2, CACNA1A
44	5-hydroxytryptamine32	8.0	COMT, PRL, ENO2, HTR1A, TPH2, DRD2
45	cocaine32 9 9	9.9	PNOC, DRD2, S100B, DRD3, COMT, PRL
46	levodopa32 9 9	9.9	SLC6A3, PRL, COMT, GSTP1, HTR1A, DRD1
47	nmda32 42	8.6	DRD2, ENO2, HTR1A, DRD1, LDLR, CCL2
48	adenylate32	7.6	DRD2, DRD1, NOS2, PNOC, LDLR, S100B
49	estrogen32	7.5	SLC6A4, PRL, COMT, NOS2, PNOC, DRD1
50	norepinephrine32 9 18 9	9.8	S100B, ENO2, CCL2, HTR1A, DRD1, DRD2

Cellular components related to migraine without aura according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	perikaryon	GO:043204	9.8	ENO2, CACNA1A, DRD2
2	neuronal cell body	GO:043025	8.7	SLC6A3, DRD4, DRD1, CCL2, S100B, PAFAH1B1
3	integral to plasma membrane	GO:005887	8.1	KCNK18, SLC6A4, SLC6A3, DRD5, DRD4, DRD3
4	plasma membrane	GO:005886	7.1	DRD3, DRD4, DRD5, COMT, SLC6A3, SLC6A4

Biological processes related to migraine without aura according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	sensitization	GO:046960	10.5	DRD5, DRD1
2	musculoskeletal movement, spinal reflex action	GO:050883	10.4	DRD3, CACNA1A
3	negative regulation of circadian sleep/wake cycle, sleep	GO:042321	10.4	DRD2, DRD1
4	adenylate cyclase-activating dopamine receptor signaling pathway	GO:007191	10.3	DRD5, DRD3, DRD1
5	positive regulation of dopamine uptake involved in synaptic transmission	GO:051586	10.3	DRD2, DRD4
6	phospholipase C-activating dopamine receptor signaling pathway	GO:060158	10.3	DRD5, DRD2, DRD1
7	negative regulation of dopamine receptor signaling pathway	GO:060160	10.3	DRD2, DRD3
8	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.2	DRD3, DRD2, DRD1
9	response to histamine	GO:034776	10.2	DRD4, DRD3, DRD2
10	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.2	DRD2, DRD3, DRD4
11	negative regulation of protein secretion	GO:050709	10.2	DRD2, DRD3, DRD4
12	regulation of long-term neuronal synaptic plasticity	GO:048169	10.2	DRD5, DRD2, DRD1
13	arachidonic acid secretion	GO:050482	10.2	DRD4, DRD3, DRD2
14	negative regulation of adenylate cyclase activity	GO:007194	10.2	DRD2, DRD3, DRD4
15	negative regulation of blood pressure	GO:045776	10.2	DRD5, DRD3, DRD2
16	regulation of dopamine metabolic process	GO:042053	10.2	SLC6A3, DRD4, DRD1
17	regulation of cAMP metabolic process	GO:030814	10.1	DRD3, DRD2
18	adult walking behavior	GO:007628	10.1	DRD2, DRD1, CACNA1A
19	behavioral response to cocaine	GO:048148	10.1	DRD1, DRD2, DRD3, DRD4
20	visual learning	GO:008542	10.1	DRD1, DRD2, DRD3, DRD5
21	dopamine metabolic process	GO:042417	10.1	DRD4, DRD3, DRD2, DRD1
22	behavioral response to ethanol	GO:048149	10.0	DRD4, DRD2
23	social behavior	GO:035176	10.0	DRD3, DRD4, SLC6A4
24	dopamine catabolic process	GO:042420	10.0	SLC6A3, COMT
25	learning or memory	GO:007611	10.0	DRD3, S100B, PAFAH1B1
26	cerebral cortex GABAergic interneuron migration	GO:021853	10.0	DRD2, DRD1
27	synaptic transmission, dopaminergic	GO:001963	9.9	DRD1, DRD2, DRD3, DRD4, DRD5
28	response to cocaine	GO:042220	9.9	DRD2, DRD3, DRD5, SLC6A3
29	prepulse inhibition	GO:060134	9.9	DRD1, DRD2, DRD3, SLC6A3
30	response to amphetamine	GO:001975	9.9	DRD5, DRD4, DRD3, DRD2, DRD1
31	synapse assembly	GO:007416	9.9	CACNA1A, DRD1, DRD2
32	response to activity	GO:014823	9.9	TNF, TPH2, CCL2
33	calcium-mediated signaling	GO:019722	9.7	IL8, TNF, DRD1
34	memory	GO:007613	9.5	S100B, DRD1, SLC6A4
35	synaptic transmission	GO:007268	9.4	SLC6A3, COMT, PNOC, DRD5, CACNA1A, KCNK18
36	cellular response to interleukin-1	GO:071347	9.2	NFKB1, CCL2, IL8
37	response to bacterium	GO:009617	9.2	CCL2, NOS2, NFKB1
38	response to hypoxia	GO:001666	9.0	SLC6A4, NOS2, DRD2, TNF, CCL2
39	cellular response to lipopolysaccharide	GO:071222	8.8	GSTP1, IL8, CCL2, NOS2
40	response to drug	GO:042493	8.5	SLC6A4, SLC6A3, COMT, DRD3, DRD2, DRD1

Molecular functions related to migraine without aura according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine receptor activity	GO:004952	10.0	DRD5, DRD4, DRD1
2	monoamine transmembrane transporter activity	GO:008504	9.9	SLC6A3, SLC6A4
3	dopamine receptor activity, coupled via Gs	GO:001588	9.8	DRD1, DRD5
4	dopamine receptor activity, coupled via Gi/Go	GO:001591	9.8	DRD4, DRD3, DRD2
5	glutathione transferase activity	GO:004364	9.3	GSTT1, GSTP1, GSTM1
6	dopamine binding	GO:035240	9.3	DRD1, DRD2, DRD3, DRD4, DRD5, SLC6A3
7	drug binding	GO:008144	9.0	SLC6A3, DRD5, DRD4, DRD3, DRD2, DRD1