MCID: MGR001
MIFTS: 52

Migraine Without Aura malady

Summaries for Migraine Without Aura

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards: Migraine Without Aura, also known as common migraine, is related to migraine and panic disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Dopamine receptors. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, monocytes and cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Description from OMIM:46 157300

Aliases & Classifications for Migraine Without Aura

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

migraine without aura 8 46 10
common migraine 8 44 60
migraine with or without aura 46


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Disease Ontology8 DOID:12783
MeSH34 D020326
ICD9CM27 346.1

Related Diseases for Migraine Without Aura

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17GeneCards, 18GeneDecks
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Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.0DRD5, PNOC, DRD4, DRD3, DRD1, KCNK18
2panic disorder30.3DRD4, TPH2, HTR1A
3bipolar disorder29.9DRD1, HTR1A, DRD3, DRD5, DRD4, TPH2
4migraine with aura11.1
5cerebritis10.5
6migraine with or without aura 110.5
7migraine with or without aura 310.5
8migraine, with or without aura 1210.5
9migraine, with or without aura 1310.5
10migraine with or without aura 510.5
11neuronitis10.4
12migraine without aura 410.4
13stroke, ischemic10.2
14neurofibromatosis10.2
15parametritis10.2
16patent foramen ovale10.2
17alexithymia10.2
18duodenitis10.2
19endometriosis10.2
20pertussis10.2
21nicotine dependence10.0DRD4
22cocaine dependence10.0DRD3
23dementia10.0HTR1A
24multiple sclerosis10.0TNF
25spinocerebellar ataxia type 310.0HTR1A
26prion disease10.0ENO2
27delusional disorder10.0DRD4
28substance abuse10.0DRD3, DRD4
29neuroblastoma10.0ENO2
30alcohol dependence10.0DRD4, DRD1
31anorexia nervosa10.0HTR1A, DRD4
32anxiety disorder10.0TPH2
33fibromyalgia10.0PNOC
34epulis10.0ENO2
35ischemia10.0HTR1A, PNOC
36ganglioneuroblastoma10.0S100B, ENO2
37pathological gambling10.0DRD1, DRD3, DRD4
38astrocytoma10.0S100B, INA
39endogenous depression10.0DRD3, HTR1A
40drug dependence10.0PNOC, DRD3
41ganglioglioma10.0S100B, ENO2
42merkel cell carcinoma10.0ENO2
43substance dependence10.0DRD3, DRD4, DRD5
44sudden infant death syndrome10.0HTR1A
45personality disorder10.0TPH2, DRD4, DRD3
46schizoaffective disorder10.0DRD4, DRD3
47olfactory neuroblastoma10.0ENO2, S100B
48chronic fatigue syndrome10.0HTR1A
49prostate small cell carcinoma10.0INA
50gilles de la tourette syndrome10.0HTR1A, DRD4, DRD3, DRD1

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Clinical Features for Migraine Without Aura

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46OMIM
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Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Migraine Without Aura

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Anatomical Context for Migraine Without Aura

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32MalaCards
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MalaCards organs/tissues related to Migraine Without Aura:

32
Brain, Monocytes, Cortex, Heart, Occipital lobe

Animal Models for Migraine Without Aura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Migraine Without Aura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.4TNF, HTR1A, DRD1, DRD3, DRD4, DRD5
2MP:00053869.1TPH2, S100B, TNF, HTR1A, DRD1, DRD3

Publications for Migraine Without Aura

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50PubMed
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Articles related to Migraine Without Aura:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Abnormal sensorimotor plasticity in migraine without aura patients. (23693159)
2013
2
Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population. (23984350)
2013
3
Executive resting-state network connectivity in migraine without aura. (22908362)
2012
4
Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1. (21964821)
2012
5
Regional homogeneity abnormalities in patients with interictal migraine without aura: a resting-state study. (22020869)
2012
6
Turn down the lights!: an irritable occipital cortex in migraine without aura. (21148117)
2011
7
Does visual cortex lactate increase following photic stimulation in migraine without aura patients? A functional (1)H-MRS study. (21301922)
2011
8
Posterior hypoperfusion in migraine without aura? (20656715)
2010
9
Matrix metalloproteinases during and outside of migraine attacks without aura. (19614693)
2010
10
Familial migraine without aura with perimenopausal onset. (20089034)
2010
11
Cutaneous application of menthol 10% solution as an abortive treatment of migraine without aura: a randomised, double-blind, placebo-controlled, crossed-over study. (20456191)
2010
12
PACAP38 induces migraine-like attacks in patients with migraine without aura. (19052139)
2009
13
Family-based analysis of serotonin transporter gene polymorphisms in migraine with and without aura. (17598758)
2007
14
Serotonin transporter protein polymorphism and harm avoidance personality in migraine without aura. (16732845)
2006
15
The functional Val158Met variant of the COMT gene is not associated with migraine with or without aura. (16767536)
2006
16
Chemokine levels in the jugular venous blood of migraine without aura patients during attacks. (15546258)
2004
17
Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities. (15022209)
2004
18
Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. (15265050)
2004
19
A locus for migraine without aura maps on chromosome 14q21.2-q22.3. (12474141)
2003
20
Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. (12967601)
2003
21
Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. (12873747)
2003
22
Localization of a gene for migraine without aura to chromosome 4q21. (14513409)
2003
23
Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. (12047331)
2002
24
Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura. (12100091)
2002
25
Dopamine receptor genes and migraine with and without aura: an association study. (12047334)
2002
26
Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1. (12473779)
2002
27
Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. (11328331)
2001
28
Genetics of migraine without aura, migraine with aura, migrainous disorder, head trauma migraine without aura and tension-type headache. (11595012)
2001
29
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. (11320173)
2001
30
Interictal and postictal contingent negative variation in migraine without aura. (11168606)
2001
31
Migraine without aura: a population-based twin study. (10514097)
1999
32
High-density assessment of the IHS classification criteria for migraine without aura: a prospective study. (10376163)
1999
33
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
34
EEG spectral analysis in migraine without aura attacks. (9731936)
1998
35
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
36
When conventional treatment is not enough: a case of migraine without aura responding to homeopathy. (9395706)
1997
37
Migraine without aura and migraine with aura are inherited disorders. (8869764)
1996
38
Ketorolac vs chlorpromazine in the treatment of acute migraine without aura. A prospective, randomized, double-blind trial. (8694672)
1996
39
Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. (8536297)
1995
40
The frontotemporal region plays a role in the genesis of migraine without aura. (7721576)
1995
41
Genesis of migraine without aura. (8530285)
1995
42
Migraine with aura and migraine without aura are two different entities. (7553806)
1995
43
Cerebral blood flow velocities are reduced during attacks of unilateral migraine without aura. (7641244)
1995
44
In vivo effects of alprazolam and lorazepam on the immune response in patients with migraine without aura. (8227969)
1993
45
Cervicogenic headache, migraine without aura and tension-type headache. Diagnostic blockade of greater occipital and supra-orbital nerves. (1454403)
1992
46
Selegeline, a MAO B inhibitor, is not effective in the prophylaxis of migraine without aura--an open study. (1399565)
1992
47
Are TNF-alpha and IL-1 beta relevant in the pathogenesis of migraine without aura? (1891987)
1991
48
Transcranial Doppler (TCD) after nitroglycerin in migraine without aura. (1774175)
1991
49
Premonitory symptoms in migraine without aura: a clinical investigation. (2093052)
1990
50
European multicenter trial of nimodipine in the prophylaxis of common migraine (migraine without aura). Migraine-Nimodipine European Study Group (MINES). (2693405)
1989

Genetic Variations for Migraine Without Aura

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Expression for genes affiliated with Migraine Without Aura

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

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Pathways for genes affiliated with Migraine Without Aura

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Migraine Without Aura

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1cis flupentixol2810.6DRD3, DRD5, DRD1
2eticlopride28 4411.6DRD3, DRD1, DRD4
3nemonapride49 44 2812.5HTR1A, DRD3, DRD4
4sch 233904410.5DRD3, DRD1, DRD4
5piribedil28 4411.5DRD4, DRD3, HTR1A
6raclopride44 2811.5DRD4, HTR1A, DRD1, DRD3
7roxindole28 4411.5HTR1A, DRD3, DRD4
8Methotrimeprazine1110.5DRD5, DRD1, DRD3, DRD4
9paliperidone44 1111.5DRD4, DRD3, DRD1, HTR1A
10iloperidone49 44 28 1113.5DRD3, DRD1, HTR1A, DRD4
11asenapine28 1111.5DRD1, DRD3, DRD4, HTR1A
12terguride28 4411.5DRD3, DRD4, HTR1A
13fluphenazine28 44 1112.5DRD1, DRD5, DRD4
14(+)-butaclamol28 4411.4DRD5, HTR1A, DRD1, DRD3, DRD4
15rotigotine44 28 1112.4DRD4, DRD1, DRD3, DRD5, HTR1A
16spiperone28 4411.4DRD4, DRD3, HTR1A, DRD5, DRD1
17ropinirole44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
18lisuride28 44 1112.4DRD3, DRD4, HTR1A, DRD1, DRD5
19piperazine44 1111.4DRD4, DRD3, HTR1A
20pergolide28 44 1112.4DRD1, HTR1A, DRD4, DRD5, DRD3
21pramipexole44 49 28 1113.4DRD5, DRD4, DRD3, DRD1, HTR1A
22cabergoline28 44 1112.4DRD4, HTR1A, DRD1, DRD5, DRD3
235-ht2810.4HTR1A, DRD5, DRD1
24aripiprazole28 49 44 11 2414.4DRD4, DRD3, DRD1, HTR1A, DRD5
25ziprasidone49 28 44 1113.4DRD4, DRD3, DRD5, HTR1A, DRD1
26apomorphine44 28 1112.4DRD1, DRD3, HTR1A, DRD4, DRD5
27quetiapine44 49 28 11 2414.4DRD1, DRD3, DRD4, DRD5, HTR1A
28risperidone28 44 49 59 11 2415.4DRD4, DRD1, DRD3, HTR1A
29chlorpromazine44 28 49 1113.4DRD4, DRD3, DRD5, DRD1, HTR1A
30bromocriptine28 44 1112.4HTR1A, DRD5, DRD4, DRD3, DRD1
31olanzapine49 44 28 11 2414.4DRD3, DRD4, DRD5, DRD1, HTR1A
32sulpiride44 28 1112.4DRD1, DRD4, DRD3
33methylphenidate44 49 1112.4DRD1, DRD4, DRD5
34levodopa44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
35clozapine44 28 49 1113.4DRD3, DRD5, DRD4, DRD1, HTR1A
36haloperidol44 28 2 49 1114.4DRD5, DRD4, DRD3, DRD1, HTR1A
37maoa4410.3TPH2, HTR1A, DRD4
38cocaine44 1111.3DRD3, DRD1, S100B, DRD4, PNOC
39catecholamine4410.3DRD3, S100B, DRD1, DRD4, DRD5, ENO2
40thioridazine28 44 49 1113.3DRD5, DRD1, HTR1A
41opiate4410.2DRD3, INA, DRD1, PNOC
42quinpirole44 2811.2DRD4, DRD3, DRD1
435-hydroxytryptamine4410.2TPH2, ENO2, PNOC, DRD4, HTR1A
44ketanserin28 4411.2HTR1A, DRD5
45potassium44 11 2412.1KCNK18, S100B, DRD3, PNOC, ENO2, DRD4
46norepinephrine44 11 2412.0DRD4, DRD1, PNOC, HTR1A, S100B, DRD3
47dopamine44 28 11 2413.0ENO2, DRD1, S100B, DRD5, DRD4, PNOC
48gaba4410.0S100B, DRD1, ENO2, DRD4, PNOC
49adenylate449.8DRD4, ENO2, PNOC, DRD1, S100B, HTR1A
50calcium44 49 11 2412.0MMP17, PNOC, DRD3, DRD1, S100B, DRD4

GO Terms for genes affiliated with Migraine Without Aura

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16Gene Ontology
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Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7MMP17, DRD5, DRD4, DRD3, DRD1, HTR1A

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.6DRD1, DRD5
2response to histamineGO:03477610.5DRD4, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.5DRD3, DRD1
4adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3, DRD5
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD3
6regulation of dopamine metabolic processGO:04205310.5DRD4, HTR1A, DRD1
7cellular response to catecholamine stimulusGO:07187010.5DRD1, DRD5
8dopamine metabolic processGO:04241710.5DRD4, DRD3, DRD1
9behavioral response to cocaineGO:04814810.5DRD1, DRD3, DRD4
10positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5DRD1, DRD5
11behavioral fear responseGO:00166210.5DRD4, DRD1, HTR1A
12synaptic transmission, dopaminergicGO:00196310.4DRD1, DRD5, DRD4, DRD3
13response to amphetamineGO:00197510.4DRD1, DRD3, DRD4, DRD5
14phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD1, DRD5
15response to glucocorticoid stimulusGO:05138410.3S100B, TPH2, TNF
16long term synaptic depressionGO:06029210.3DRD5, DRD1
17arachidonic acid secretionGO:05048210.3DRD3, DRD4
18cellular calcium ion homeostasisGO:00687410.3DRD3, DRD5, DRD4
19negative regulation of protein secretionGO:05070910.2DRD3, DRD4
20prepulse inhibitionGO:06013410.0DRD3, DRD1

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD3, DRD4
2dopamine bindingGO:03524010.1DRD1, DRD3, DRD4, DRD5
3dopamine neurotransmitter receptor activityGO:00495210.1DRD1, DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.0DRD1, DRD5

Products for genes affiliated with Migraine Without Aura

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
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