MCID: MGR001
MIFTS: 55

Migraine Without Aura malady

Neuronal diseases category
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Summaries for Migraine Without Aura

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Disease Ontology:8 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards based summary: Migraine Without Aura, also known as common migraine, is related to migraine and panic disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Hypothetical Network for Drug Addiction and Monoamine Transport. The compounds skf 81297 hydrobromide and sch 23390 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are vision/eye and adipose tissue.

Description from OMIM:46 157300

Aliases & Classifications for Migraine Without Aura

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Migraine Without Aura, Aliases & Descriptions:

Name: Migraine Without Aura 8 46 10 62
Common Migraine 8 44 62
 
Migraine with or Without Aura 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:12783
MeSH34 D020326
ICD9CM27 346.1

Related Diseases for Migraine Without Aura

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Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.1DRD3, HTR1A, EDNRA, DRD4, DRD5, DRD1
2panic disorder30.2HTR1A, DRD4, TPH2
3bipolar disorder29.2DRD3, DRD4, DRD1, HTR1A, TPH2, DRD5
4migraine with aura10.9
5headache10.9
6blindness10.7
7cerebritis10.5
8migraine with or without aura 110.5
9migraine with or without aura 310.5
10migraine, with or without aura 1210.5
11migraine, with or without aura 1310.5
12migraine with or without aura 510.5
13delusional disorder10.4DRD4
14neuronitis10.4
15endometriosis10.4
16cluster headache10.4
17migraine without aura 410.4
18nicotine dependence10.3DRD4
19alcohol dependence10.3DRD1, DRD4
20parametritis10.2
21patent foramen ovale10.2
22neurofibromatosis10.2
23alexithymia10.2
24duodenitis10.2
25pertussis10.2
26hemicrania continua10.2
27hypersomnia10.2
28substance abuse10.2DRD3, DRD4
29conduct disorder10.2DRD4, DRD5
30drug addiction10.2DRD3, DRD1
31endogenous depression10.2DRD3, HTR1A
32schizoaffective disorder10.2DRD4, DRD3
33gilles de la tourette syndrome10.2DRD4, DRD5
34seasonal affective disorder10.1DRD4, HTR1A
35pathological gambling10.1DRD1, DRD3, DRD4
36substance dependence10.1DRD5, DRD4, DRD3
37toxic shock syndrome10.0TNF, EDNRA
38memory impairment10.0DRD1, HTR1A
39familial hemiplegic migraine10.0
40carotidynia10.0
41hemiplegic migraine10.0
42personality disorder10.0TPH2, DRD4, DRD3
43anxiety disorder10.0TPH2, HTR1A
44essential hypertension9.9DRD5, EDNRA, DRD1
45anorexia nervosa9.9DRD4, HTR1A
46attention deficit hyperactivity disorder9.8DRD4, DRD5, TPH2, DRD1
47parkinson's disease9.8DRD1, HTR1A, DRD3, DRD4
48alzheimer's disease9.8HTR1A, DRD3, DRD1, DRD4
49viral infectious disease9.7EDNRA, TNF, HTR1A
50obesity9.7EDNRA, HTR1A, DRD4, TNF

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Symptoms for Migraine Without Aura

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Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

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Drug clinical trials:

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Genetic Tests for Migraine Without Aura

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Anatomical Context for Migraine Without Aura

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MalaCards organs/tissues related to Migraine Without Aura:

32
Brain, Cortex, Monocytes, Heart, Occipital lobe

Animal Models for Migraine Without Aura or affiliated genes

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MGI Mouse Phenotypes related to Migraine Without Aura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9DRD1, DRD5, DRD4, TNF
2MP:00053758.5TNF, TPH2, DRD3, DRD1
3MP:00053818.5EDNRA, TNF, DRD3, DRD1
4MP:00053888.3DRD1, TPH2, TNF, EDNRA
5MP:00053867.4TNF, TPH2, HTR1A, DRD4, DRD3, DRD1
6MP:00107687.3EDNRA, TNF, TPH2, HTR1A, DRD3, DRD1
7MP:00053857.1EDNRA, TNF, TPH2, HTR1A, DRD5, DRD3
8MP:00053766.9EDNRA, TNF, TPH2, HTR1A, DRD4, DRD3
9MP:00036316.6DRD1, EDNRA, TNF, TPH2, HTR1A, DRD4

Publications for Migraine Without Aura

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Articles related to Migraine Without Aura:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Cognitive dysfunction during migraine attacks: A study on migraine without aura. (25324500)
2014
2
Temperamental characteristics in childhood migraine without aura: a multicenter study. (23983467)
2013
3
Disrupted default mode network connectivity in migraine without aura. (24207164)
2013
4
Effectiveness and safety of Nintendo Wii Fit Plusa8c training in children with migraine without aura: a preliminary study. (24453490)
2013
5
Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. (24134520)
2013
6
Self-concept evaluation and migraine without aura in childhood. (23950647)
2013
7
Fatigue is increased in episodic migraine without aura patients. (23865916)
2013
8
A case of migraine without aura that was successfully treated with an herbal medicine. (23758551)
2013
9
A Japanese SUNA patient with migraine without aura and medication overuse headache responsive to topiramate. (24097323)
2013
10
Abnormal sensorimotor plasticity in migraine without aura patients. (23693159)
2013
11
I+-[11C] methyl-L tryptophan-PET as a surrogate for interictal cerebral serotonin synthesis in migraine without aura. (24057438)
2013
12
Hypersomnia in children affected by migraine without aura: a questionnaire-based case-control study. (23459616)
2013
13
Sublingual piroxicam in migraine without aura. (21887905)
2011
14
31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. (21289000)
2011
15
A case of strictly unilateral migraine without aura transformed in an episodic hemicrania continua. (20924631)
2011
16
Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration? (21293918)
2011
17
Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation. (21533737)
2011
18
Turn down the lights!: an irritable occipital cortex in migraine without aura. (21148117)
2011
19
Posterior hypoperfusion in migraine without aura? (20656715)
2010
20
Posterior cerebral hypoperfusion in migraine without aura. (18513260)
2008
21
Migraine without aura: comparison with cervicogenic headache. VAYgAY study of headache epidemiology. (18031560)
2008
22
Reversible imaging abnormalities consistent with CSD during migraine without aura attack. (18819183)
2008
23
Stereotyped topography of different elevated contingent negative variation components in children with migraine without aura points towards a subcortical dysfunction. (17027155)
2007
24
Seizures with prolonged EEG abnormalities during an attack of migraine without aura. (17578546)
2007
25
Serotonin transporter protein polymorphism and harm avoidance personality in migraine without aura. (16732845)
2006
26
Diagnostic criteria of pediatric migraine without aura. (16562783)
2006
27
Sleep quality, chronotypes and preferential timing of attacks in migraine without aura. (16362680)
2005
28
Plasma nociceptin levels are reduced in migraine without aura. (15773823)
2005
29
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. (15182958)
2004
30
Monozygotic twin sisters suffering from cluster headache and migraine without aura. (12796556)
2003
31
A locus for migraine without aura maps on chromosome 14q21.2-q22.3. (12474141)
2003
32
Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. (12047331)
2002
33
Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura. (12100091)
2002
34
Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. (12390611)
2002
35
Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. (11328331)
2001
36
Chiropractic management of migraine without aura. A case study. (17987195)
1999
37
Migraine without aura: a population-based twin study. (10514097)
1999
38
Weekend headache: a retrospective study in migraine without aura and episodic tension-type headache. (15613189)
1999
39
The relative role of genetic and environmental factors in migraine without aura. (10496258)
1999
40
Coexistence of cervicogenic headache and migraine without aura (?). (10713894)
1999
41
Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura. (9601620)
1998
42
QEEG in migraine without aura. (9731930)
1998
43
Migraine without aura and ACE-gene deletion polymorphism: is there a correlation? Preliminary findings. (9358966)
1997
44
A study of symptomatic drug use in migraine without aura. (8749703)
1995
45
Cognitive functions in migraine without aura between attacks: a psychophysiological approach using the "oddball" paradigm. (7746225)
1995
46
Thresholds for detection of a target against a background grating suggest visual dysfunction in migraine with aura but not migraine without aura. (7641245)
1995
47
The frontotemporal region plays a role in the genesis of migraine without aura. (7721576)
1995
48
Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. (8376100)
1993
49
Migraine without aura and ischemic stroke. (1517072)
1992
50
Autonomic nervous system function in migraine without aura. (1774161)
1991

Variations for Migraine Without Aura

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Expression for genes affiliated with Migraine Without Aura

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Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

Search GEO for disease gene expression data for Migraine Without Aura.

Pathways for genes affiliated with Migraine Without Aura

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Pathways related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DRD1, DRD4
2
Show member pathways
Serotonin Transporter Activity37
9.3TPH2, TNF
39.2DRD1, DRD5, EDNRA
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.1DRD1, DRD3, DRD4
59.0TPH2, HTR1A
69.0DRD3, DRD4, EDNRA
78.7DRD4, DRD5, DRD3, DRD1
8
Show member pathways
8.7DRD4, DRD5, DRD3, DRD1
98.7TNF, TPH2, HTR1A
10
Show member pathways
8.1DRD1, DRD3, DRD5, DRD4, HTR1A
11
Show member pathways
7.6EDNRA, HTR1A, DRD4, DRD5, DRD3, DRD1
12
Show member pathways
7.6EDNRA, HTR1A, DRD4, DRD5, DRD3, DRD1
13
Show member pathways
7.3TPH2, HTR1A, DRD4, DRD5, DRD3, DRD1

Compounds for genes affiliated with Migraine Without Aura

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Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1skf 81297 hydrobromide619.8DRD5, DRD1
2sch 23390 hydrochloride619.8DRD1, DRD5
3sch 39166 hydrobromide619.7DRD5, DRD1
4skf-76783289.7DRD1, DRD5
5cis flupentixol289.6DRD5, DRD1, DRD3
6skf 38393 hydrobromide619.6DRD1, DRD5
7fluphenazine28 44 50 1112.5DRD4, DRD5, DRD1
8eticlopride44 2810.5DRD1, DRD3, DRD4
9methylphenidate44 50 1111.5DRD5, DRD1, DRD4
10sch 23390449.4DRD4, DRD3, DRD1
11skf 83959 hydrobromide619.4DRD1, DRD5
125-ht289.4HTR1A, DRD1, DRD5
13sulpiride44 28 1111.4DRD4, DRD3, DRD1
14thioridazine28 44 50 1112.3DRD5, HTR1A, DRD1
15ketanserin44 2810.3DRD1, DRD5, HTR1A
16quinpirole44 2810.3DRD4, DRD1, DRD3
17nemonapride44 50 2811.2DRD3, HTR1A, DRD4
18piribedil28 4410.2DRD4, HTR1A, DRD3
19roxindole28 4410.2HTR1A, DRD3, DRD4
20terguride44 2810.2DRD4, HTR1A, DRD3
21piperazine44 1110.2DRD3, DRD4, HTR1A
22paroxetine44 50 28 1112.0DRD4, DRD3, HTR1A
23catecholamine449.0DRD5, DRD3, DRD1, DRD4
24raclopride44 289.9DRD3, DRD4, HTR1A, DRD1
25paliperidone44 119.9DRD1, DRD3, HTR1A, DRD4
26iloperidone50 44 28 1111.9HTR1A, DRD4, DRD3, DRD1
27asenapine28 119.8HTR1A, DRD4, DRD1, DRD3
28risperidone44 50 28 61 24 1113.8HTR1A, DRD3, DRD4, DRD1
29maoa448.8DRD4, HTR1A, TPH2
30(+)-butaclamol44 289.5DRD3, DRD1, DRD5, DRD4, HTR1A
31rotigotine28 44 1110.5DRD5, DRD1, DRD4, DRD3, HTR1A
32spiperone44 289.5HTR1A, DRD1, DRD3, DRD4, DRD5
33ropinirole44 119.5HTR1A, DRD3, DRD5, DRD4, DRD1
34lisuride44 28 1110.5DRD3, DRD4, DRD5, DRD1, HTR1A
35pergolide44 28 1110.5DRD5, DRD1, DRD3, DRD4, HTR1A
36pramipexole44 28 50 1111.5DRD1, DRD5, DRD4, HTR1A, DRD3
37cabergoline44 28 1110.5DRD3, DRD5, DRD4, DRD1, HTR1A
38aripiprazole28 44 50 24 1112.5DRD1, DRD4, DRD3, DRD5, HTR1A
39ziprasidone28 50 44 1111.5DRD1, HTR1A, DRD4, DRD5, DRD3
40apomorphine28 44 1110.5HTR1A, DRD1, DRD3, DRD5, DRD4
41quetiapine44 50 28 24 1112.5DRD5, DRD4, DRD3, HTR1A, DRD1
42bromocriptine44 28 1110.5DRD3, HTR1A, DRD4, DRD5, DRD1
43chlorpromazine28 44 50 1111.5DRD1, HTR1A, DRD4, DRD5, DRD3
44olanzapine44 50 28 24 1112.5DRD4, DRD5, HTR1A, DRD1, DRD3
45levodopa44 119.5DRD5, DRD4, DRD3, DRD1, HTR1A
46clozapine44 28 50 1111.5DRD1, DRD3, HTR1A, DRD5, DRD4
47haloperidol44 50 28 2 1112.5HTR1A, DRD1, DRD4, DRD3, DRD5
48cyclic amp44 249.4DRD3, EDNRA, DRD5, DRD4, DRD1
49norepinephrine44 24 1110.0DRD5, DRD1, DRD4, EDNRA, HTR1A, DRD3
50dopamine44 28 24 1110.9DRD3, DRD1, DRD4, DRD5, HTR1A, EDNRA

GO Terms for genes affiliated with Migraine Without Aura

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Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.2TNF, HTR1A, DRD4, DRD5, DRD3, DRD1
2integral component of plasma membraneGO:0058876.9DRD1, EDNRA, TNF, HTR1A, DRD4, DRD5

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.1DRD5, DRD1
2cellular response to catecholamine stimulusGO:07187010.1DRD1, DRD5
3positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.1DRD5, DRD1
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.1DRD1, DRD5
5long term synaptic depressionGO:06029210.0DRD5, DRD1
6regulation of dopamine uptake involved in synaptic transmissionGO:05158410.0DRD1, DRD3
7transmission of nerve impulseGO:01922610.0DRD1, DRD5
8prepulse inhibitionGO:06013410.0DRD1, DRD3
9positive regulation of mitosisGO:0458409.9DRD3, TNF
10response to cocaineGO:0422209.9DRD5, DRD3
11response to histamineGO:0347769.9DRD3, DRD4
12negative regulation of blood pressureGO:0457769.9DRD5, DRD3
13adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.9DRD3, DRD4
14positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:0514829.9EDNRA, DRD1
15negative regulation of protein secretionGO:0507099.9DRD4, DRD3
16positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8DRD1, EDNRA
17arachidonic acid secretionGO:0504829.8DRD4, DRD3
18adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8DRD5, DRD1
19negative regulation of cAMP biosynthetic processGO:0308189.8EDNRA, DRD4
20response to morphineGO:0432789.8EDNRA, DRD3
21negative regulation of adenylate cyclase activityGO:0071949.8DRD3, DRD4
22adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.6DRD5, DRD3, DRD1
23vasoconstrictionGO:0423109.6EDNRA, HTR1A
24visual learningGO:0085429.6DRD1, DRD3
25activation of adenylate cyclase activityGO:0071909.6DRD1, DRD5, EDNRA
26social behaviorGO:0351769.6DRD3, DRD4
27response to activityGO:0148239.5TPH2, TNF
28cellular calcium ion homeostasisGO:0068749.5DRD4, DRD5, DRD3
29dopamine metabolic processGO:0424179.5DRD4, DRD3, DRD1
30behavioral response to cocaineGO:0481489.5DRD1, DRD3, DRD4
31response to drugGO:0424939.5TNF, DRD3, DRD1
32regulation of dopamine metabolic processGO:0420539.3HTR1A, DRD4, DRD1
33response to glucocorticoidGO:0513849.3TPH2, TNF
34behavioral fear responseGO:0016629.3HTR1A, DRD4, DRD1
35synaptic transmission, dopaminergicGO:0019639.1DRD1, DRD3, DRD5, DRD4
36response to amphetamineGO:0019759.1DRD1, DRD3, DRD5, DRD4
37circadian rhythmGO:0076239.0TPH2, DRD4
38G-protein coupled receptor signaling pathwayGO:0071869.0DRD3, HTR1A, EDNRA
39positive regulation of cell proliferationGO:0082848.6DRD3, HTR1A, EDNRA

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:0015889.6DRD1, DRD5
2drug bindingGO:0081449.5DRD3, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.2DRD3, DRD4
4dopamine neurotransmitter receptor activityGO:0049529.2DRD4, DRD5, DRD1
5dopamine bindingGO:0352408.8DRD1, DRD3, DRD5, DRD4

Products for genes affiliated with Migraine Without Aura

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Sources for Migraine Without Aura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet