MCID: MGR001
MIFTS: 39

Migraine Without Aura malady

Summaries for Migraine Without Aura

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards: Migraine Without Aura, also known as common migraine, is related to panic disorder and bipolar disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Dopamine receptors. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Description from OMIM:47 157300

Aliases & Classifications for Migraine Without Aura

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

migraine without aura 8 47 10
common migraine 8 45 61
migraine with or without aura 47


External Ids:

Disease Ontology8 DOID:12783
MeSH35 D020326
ICD9CM27 346.1

Related Diseases for Migraine Without Aura

Sources:
17GeneCards, 18GeneDecks
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Diseases in the migraine family:

migraine without aura migraine with aura
migraine with or without aura 1 migraine 8
migraine with or without aura 3 migraine, with or without aura 12
migraine, with or without aura 13 migraine with aura 9
migraine without aura 4 migraine with aura 7
migraine with or without aura 5

Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.3TPH2, DRD4, HTR1A
2bipolar disorder29.9HTR1A, DRD1, DRD3, DRD4, DRD5, TPH2
3headache10.9
4migraine with or without aura 110.5
5migraine with or without aura 310.5
6migraine, with or without aura 1210.5
7migraine, with or without aura 1310.5
8migraine with or without aura 510.5
9cluster headache10.4
10migraine without aura 410.4
11stroke, ischemic10.2
12neurofibromatosis10.2
13patent foramen ovale10.2
14alexithymia10.2
15hemicrania continua10.2
16hypersomnia10.2
17migraine 810.2
18h. pylori infection10.2
19nicotine dependence10.0DRD4
20cocaine dependence10.0DRD3
21dementia10.0HTR1A
22multiple sclerosis10.0TNF
23spinocerebellar ataxia type 310.0HTR1A
24prion disease10.0ENO2
25delusional disorder10.0DRD4
26substance abuse10.0DRD4, DRD3
27neuroblastoma10.0ENO2
28alcohol dependence10.0DRD4, DRD1
29anorexia nervosa10.0DRD4, HTR1A
30anxiety disorder10.0TPH2
31fibromyalgia10.0PNOC
32epulis10.0ENO2
33ischemia10.0HTR1A, PNOC
34pathological gambling10.0DRD1, DRD3, DRD4
35ganglioneuroblastoma10.0ENO2, S100B
36astrocytoma10.0INA, S100B
37endogenous depression10.0HTR1A, DRD3
38drug dependence10.0PNOC, DRD3
39ganglioglioma10.0S100B, ENO2
40merkel cell carcinoma10.0ENO2
41substance dependence10.0DRD5, DRD4, DRD3
42sudden infant death syndrome10.0HTR1A
43personality disorder10.0TPH2, DRD4, DRD3
44schizoaffective disorder10.0DRD4, DRD3
45olfactory neuroblastoma10.0S100B, ENO2
46chronic fatigue syndrome10.0HTR1A
47prostate small cell carcinoma10.0INA
48down syndrome10.0S100B, HTR1A
49gilles de la tourette syndrome10.0HTR1A, DRD1, DRD3, DRD4
50attention deficit hyperactivity disorder10.0DRD1, DRD4, DRD5, TPH2

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Clinical Features for Migraine Without Aura

Sources:
47OMIM
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Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Migraine Without Aura

Search CenterWatch for Migraine Without Aura

Genetic Tests for Migraine Without Aura

Anatomical Context for Migraine Without Aura

Animal Models for Migraine Without Aura or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Migraine Without Aura:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.4TNF, HTR1A, DRD1, DRD3, DRD4, DRD5
2MP:00053869.1TPH2, S100B, TNF, HTR1A, DRD1, DRD3

Publications for Migraine Without Aura

Genetic Variations for Migraine Without Aura

Expression for genes affiliated with Migraine Without Aura

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

Search GEO for disease gene expression data for Migraine Without Aura.

Pathways for genes affiliated with Migraine Without Aura

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG
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Compounds for genes affiliated with Migraine Without Aura

Sources:
29IUPHAR, 45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1cis flupentixol2910.6DRD3, DRD5, DRD1
2eticlopride29 4511.6DRD3, DRD1, DRD4
3nemonapride50 45 2912.5HTR1A, DRD3, DRD4
4sch 233904510.5DRD3, DRD1, DRD4
5piribedil29 4511.5DRD4, DRD3, HTR1A
6raclopride45 2911.5DRD4, HTR1A, DRD1, DRD3
7roxindole29 4511.5HTR1A, DRD3, DRD4
8Methotrimeprazine1110.5DRD5, DRD1, DRD3, DRD4
9paliperidone45 1111.5DRD4, DRD3, DRD1, HTR1A
10iloperidone50 45 29 1113.5DRD3, DRD1, HTR1A, DRD4
11asenapine29 1111.5DRD1, DRD3, DRD4, HTR1A
12terguride29 4511.5DRD3, DRD4, HTR1A
13fluphenazine29 45 1112.5DRD1, DRD5, DRD4
14(+)-butaclamol29 4511.4DRD5, HTR1A, DRD1, DRD3, DRD4
15rotigotine45 29 1112.4DRD4, DRD1, DRD3, DRD5, HTR1A
16spiperone29 4511.4DRD4, DRD3, HTR1A, DRD5, DRD1
17ropinirole45 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
18lisuride29 45 1112.4DRD3, DRD4, HTR1A, DRD1, DRD5
19piperazine45 1111.4DRD4, DRD3, HTR1A
20pergolide29 45 1112.4DRD1, HTR1A, DRD4, DRD5, DRD3
21pramipexole45 50 29 1113.4DRD5, DRD4, DRD3, DRD1, HTR1A
22cabergoline29 45 1112.4DRD4, HTR1A, DRD1, DRD5, DRD3
235-ht2910.4HTR1A, DRD5, DRD1
24aripiprazole29 50 45 11 2414.4DRD4, DRD3, DRD1, HTR1A, DRD5
25ziprasidone50 29 45 1113.4DRD4, DRD3, DRD5, HTR1A, DRD1
26apomorphine45 29 1112.4DRD1, DRD3, HTR1A, DRD4, DRD5
27quetiapine45 50 29 11 2414.4DRD1, DRD3, DRD4, DRD5, HTR1A
28risperidone29 45 50 60 11 2415.4DRD4, DRD1, DRD3, HTR1A
29chlorpromazine45 29 50 1113.4DRD4, DRD3, DRD5, DRD1, HTR1A
30bromocriptine29 45 1112.4HTR1A, DRD5, DRD4, DRD3, DRD1
31olanzapine50 45 29 11 2414.4DRD3, DRD4, DRD5, DRD1, HTR1A
32sulpiride45 29 1112.4DRD1, DRD4, DRD3
33methylphenidate45 50 1112.4DRD1, DRD4, DRD5
34levodopa45 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
35clozapine45 29 50 1113.4DRD3, DRD5, DRD4, DRD1, HTR1A
36haloperidol45 29 2 50 1114.4DRD5, DRD4, DRD3, DRD1, HTR1A
37maoa4510.3TPH2, HTR1A, DRD4
38cocaine45 1111.3DRD3, DRD1, S100B, DRD4, PNOC
39catecholamine4510.3DRD3, S100B, DRD1, DRD4, DRD5, ENO2
40thioridazine29 45 50 1113.3DRD5, DRD1, HTR1A
41opiate4510.2DRD3, INA, DRD1, PNOC
42quinpirole45 2911.2DRD4, DRD3, DRD1
435-hydroxytryptamine4510.2TPH2, ENO2, PNOC, DRD4, HTR1A
44ketanserin29 4511.2HTR1A, DRD5
45potassium45 11 2412.1KCNK18, S100B, DRD3, PNOC, ENO2, DRD4
46norepinephrine45 11 2412.0DRD4, DRD1, PNOC, HTR1A, S100B, DRD3
47dopamine45 29 11 2413.0ENO2, DRD1, S100B, DRD5, DRD4, PNOC
48gaba4510.0S100B, DRD1, ENO2, DRD4, PNOC
49adenylate459.8DRD4, ENO2, PNOC, DRD1, S100B, HTR1A
50calcium45 50 11 2412.0MMP17, PNOC, DRD3, DRD1, S100B, DRD4

GO Terms for genes affiliated with Migraine Without Aura

Sources:
16Gene Ontology
See all sources

Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7MMP17, DRD5, DRD4, DRD3, DRD1, HTR1A

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.6DRD5, DRD1
2response to histamineGO:03477610.5DRD3, DRD4
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.5DRD3, DRD1
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD3
5dopamine metabolic processGO:04241710.5DRD1, DRD3, DRD4
6regulation of dopamine metabolic processGO:04205310.5DRD4, DRD1, HTR1A
7adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3, DRD5
8cellular response to catecholamine stimulusGO:07187010.5DRD1, DRD5
9behavioral response to cocaineGO:04814810.5DRD4, DRD3, DRD1
10positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5DRD5, DRD1
11behavioral fear responseGO:00166210.5HTR1A, DRD1, DRD4
12synaptic transmission, dopaminergicGO:00196310.4DRD5, DRD4, DRD3, DRD1
13response to amphetamineGO:00197510.4DRD1, DRD3, DRD4, DRD5
14phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD1, DRD5
15response to glucocorticoid stimulusGO:05138410.3TPH2, TNF, S100B
16long term synaptic depressionGO:06029210.3DRD5, DRD1
17arachidonic acid secretionGO:05048210.3DRD4, DRD3
18cellular calcium ion homeostasisGO:00687410.3DRD5, DRD4, DRD3
19negative regulation of protein secretionGO:05070910.2DRD3, DRD4
20prepulse inhibitionGO:06013410.0DRD3, DRD1

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3
2dopamine bindingGO:03524010.1DRD5, DRD4, DRD3, DRD1
3dopamine neurotransmitter receptor activityGO:00495210.1DRD1, DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.0DRD5, DRD1

Products for genes affiliated with Migraine Without Aura

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Sources for Migraine Without Aura

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet