MCID: MGR001
MIFTS: 52

Migraine Without Aura malady

Summaries for Migraine Without Aura

About this section
Sources:
8Disease Ontology, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A migraine that is characterized by migraine headaches that are not accompanied by an aura.

MalaCards: Migraine Without Aura, also known as common migraine, is related to migraine and panic disorder. An important gene associated with Migraine Without Aura is TNF (tumor necrosis factor), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Dopamine receptors. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are nervous system and behavior/neurological.

Description from OMIM:46 157300

Aliases & Classifications for Migraine Without Aura

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

migraine without aura 8 46 10
common migraine 8 44 60
migraine with or without aura 46


External Ids:

Disease Ontology8 DOID:12783
MeSH34 D020326
ICD9CM27 346.1

Related Diseases for Migraine Without Aura

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Migraine Without Aura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.0DRD5, PNOC, DRD4, DRD3, DRD1, KCNK18
2panic disorder30.3DRD4, TPH2, HTR1A
3bipolar disorder29.9DRD1, HTR1A, DRD3, DRD5, DRD4, TPH2
4migraine with aura11.1
5cerebritis10.5
6migraine with or without aura 110.5
7migraine with or without aura 310.5
8migraine, with or without aura 1210.5
9migraine, with or without aura 1310.5
10migraine with or without aura 510.5
11neuronitis10.4
12migraine without aura 410.4
13stroke, ischemic10.2
14neurofibromatosis10.2
15parametritis10.2
16patent foramen ovale10.2
17alexithymia10.2
18duodenitis10.2
19endometriosis10.2
20pertussis10.2
21nicotine dependence10.0DRD4
22cocaine dependence10.0DRD3
23dementia10.0HTR1A
24multiple sclerosis10.0TNF
25spinocerebellar ataxia type 310.0HTR1A
26prion disease10.0ENO2
27delusional disorder10.0DRD4
28substance abuse10.0DRD3, DRD4
29neuroblastoma10.0ENO2
30alcohol dependence10.0DRD4, DRD1
31anorexia nervosa10.0HTR1A, DRD4
32anxiety disorder10.0TPH2
33fibromyalgia10.0PNOC
34epulis10.0ENO2
35ischemia10.0HTR1A, PNOC
36ganglioneuroblastoma10.0S100B, ENO2
37pathological gambling10.0DRD1, DRD3, DRD4
38astrocytoma10.0S100B, INA
39endogenous depression10.0DRD3, HTR1A
40drug dependence10.0PNOC, DRD3
41ganglioglioma10.0S100B, ENO2
42merkel cell carcinoma10.0ENO2
43substance dependence10.0DRD3, DRD4, DRD5
44sudden infant death syndrome10.0HTR1A
45personality disorder10.0TPH2, DRD4, DRD3
46schizoaffective disorder10.0DRD4, DRD3
47olfactory neuroblastoma10.0ENO2, S100B
48chronic fatigue syndrome10.0HTR1A
49prostate small cell carcinoma10.0INA
50gilles de la tourette syndrome10.0HTR1A, DRD4, DRD3, DRD1

Graphical network of the top 20 diseases related to Migraine Without Aura:



Diseases related to migraine without aura

Clinical Features for Migraine Without Aura

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

157300

Drugs & Therapeutics for Migraine Without Aura

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Migraine Without Aura

Drug clinical trials:

Search ClinicalTrials for Migraine Without Aura

Search NIH Clinical Center for Migraine Without Aura

Search CenterWatch for Migraine Without Aura

Genetic Tests for Migraine Without Aura

About this section

Anatomical Context for Migraine Without Aura

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Migraine Without Aura:

32
Brain, Cortex, Monocytes, Heart, Occipital lobe

Animal Models for Migraine Without Aura or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Migraine Without Aura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.4TNF, HTR1A, DRD1, DRD3, DRD4, DRD5
2MP:00053869.1TPH2, S100B, TNF, HTR1A, DRD1, DRD3

Publications for Migraine Without Aura

About this section
Sources:
50PubMed
See all sources

Articles related to Migraine Without Aura:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: A randomized study. (24363238)
2014
2
Fatigue is increased in episodic migraine without aura patients. (23865916)
2013
3
I+-[11C] methyl-L tryptophan-PET as a surrogate for interictal cerebral serotonin synthesis in migraine without aura. (24057438)
2013
4
Hypersomnia in children affected by migraine without aura: a questionnaire-based case-control study. (23459616)
2013
5
Evaluating the prophylaxis and long-term effectiveness of acupuncture for migraine without aura: study protocol for a randomized controlled trial. (24171782)
2013
6
Lack of association between GRIA1 polymorphisms and haplotypes with migraine without aura or response to triptans. (24030684)
2013
7
Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura. (23348909)
2013
8
Alexithymia and its impact on quality of life in a group of Brazilian women with migraine without aura. (23565860)
2013
9
Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study. (23511357)
2013
10
Axonal loss of white matter in migraine without aura: a tract-based spatial statistics study. (23150889)
2013
11
The effect of patent foramen ovale closure on visual aura without headache or typical aura with migraine headache. (22721665)
2012
12
Sublingual piroxicam in migraine without aura. (21887905)
2011
13
31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. (21289000)
2011
14
(1)H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique. (20706770)
2010
15
Mixture analysis of age at onset in migraine without aura: evidence for three subgroups. (20408885)
2010
16
Perimenstrual headache: migraine without aura or premenstrual syndrome symptom? (21417101)
2010
17
Peri-ictal changes of cortical excitability in children suffering from migraine without aura. (19796876)
2009
18
Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. (17690944)
2008
19
Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study. (18727636)
2008
20
Clinical correlates of phosphene perception in migraine without aura: an Asian study. (17720202)
2008
21
Tension-type headache: comparison with migraine without aura and cervicogenic headache. The VAYgAY study of headache epidemiology. (18671906)
2008
22
Cervicogenic headache: comparison with migraine without aura; VAYgAY study. (18494988)
2008
23
Helicobacter pylori infection as an environmental risk factor for migraine without aura. (18071631)
2007
24
Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura. (19513339)
2007
25
Diagnostic criteria of pediatric migraine without aura. (16562783)
2006
26
Dipyridamole may induce migraine in patients with migraine without aura. (16886928)
2006
27
Dysfunction of arousal systems in sleep-related migraine without aura. (16776702)
2006
28
Migraine with aura and migraine without aura are not distinct entities: further evidence from a large Dutch population study. (16611468)
2006
29
Gender ratio of migraine without aura: observations over time. (16688599)
2006
30
Plasma nociceptin levels are reduced in migraine without aura. (15773823)
2005
31
Migraine aura without headache compared to migraine with aura in patients with affective disorders. (16362710)
2005
32
Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype. (16362702)
2005
33
Conversion from migraine without aura to typical aura without headache after irbesartan. (16362652)
2005
34
Glutathione S-transferase polymorphisms: susceptibility to migraine without aura. (12736537)
2003
35
Migraine with aura versus migraine without aura: pain intensity and associated symptom intensities after placebo. (12390612)
2002
36
Migraine without aura and migrainous disorder in children; International Headache Society (IHS) and revised IHS criteria. (11128818)
2000
37
Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients. (10961765)
2000
38
Comparison of pharmacological treatment versus acupuncture treatment for migraine without aura--analysis of socio-medical parameters. (11038990)
2000
39
Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance. (10940095)
2000
40
Pattern reversal visual evoked potentials in migraine with aura and migraine aura without headache. (9731935)
1998
41
Migrainous disorder and its relation to migraine without aura and migraine with aura. A genetic epidemiological study. (8902253)
1996
42
Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population. (8792035)
1996
43
Cognitive functions in migraine without aura between attacks: a psychophysiological approach using the "oddball" paradigm. (7746225)
1995
44
Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. (7641249)
1995
45
Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura. (8530012)
1995
46
Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study. (8164818)
1994
47
Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. (8376100)
1993
48
Effectiveness of a piroxicam fast dissolving formulation sublingually administered in the symptomatic treatment of migraine without aura. (8349471)
1993
49
Migraine with aura and migraine without aura: an epidemiological study. (1525797)
1992
50
Exaggerated spontaneous release of tumor necrosis factor-alpha/cachectin in patients with migraine without aura. (2251950)
1990

Genetic Variations for Migraine Without Aura

About this section

Expression for genes affiliated with Migraine Without Aura

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Migraine Without Aura

Search GEO for disease gene expression data for Migraine Without Aura.

Pathways for genes affiliated with Migraine Without Aura

About this section
Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
See all sources

Compounds for genes affiliated with Migraine Without Aura

About this section
Sources:
28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Migraine Without Aura according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1cis flupentixol2810.6DRD3, DRD5, DRD1
2eticlopride28 4411.6DRD3, DRD1, DRD4
3nemonapride49 44 2812.5HTR1A, DRD3, DRD4
4sch 233904410.5DRD3, DRD1, DRD4
5piribedil28 4411.5DRD4, DRD3, HTR1A
6raclopride44 2811.5DRD4, HTR1A, DRD1, DRD3
7roxindole28 4411.5HTR1A, DRD3, DRD4
8Methotrimeprazine1110.5DRD5, DRD1, DRD3, DRD4
9paliperidone44 1111.5DRD4, DRD3, DRD1, HTR1A
10iloperidone49 44 28 1113.5DRD3, DRD1, HTR1A, DRD4
11asenapine28 1111.5DRD1, DRD3, DRD4, HTR1A
12terguride28 4411.5DRD3, DRD4, HTR1A
13fluphenazine28 44 1112.5DRD1, DRD5, DRD4
14(+)-butaclamol28 4411.4DRD5, HTR1A, DRD1, DRD3, DRD4
15rotigotine44 28 1112.4DRD4, DRD1, DRD3, DRD5, HTR1A
16spiperone28 4411.4DRD4, DRD3, HTR1A, DRD5, DRD1
17ropinirole44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
18lisuride28 44 1112.4DRD3, DRD4, HTR1A, DRD1, DRD5
19piperazine44 1111.4DRD4, DRD3, HTR1A
20pergolide28 44 1112.4DRD1, HTR1A, DRD4, DRD5, DRD3
21pramipexole44 49 28 1113.4DRD5, DRD4, DRD3, DRD1, HTR1A
22cabergoline28 44 1112.4DRD4, HTR1A, DRD1, DRD5, DRD3
235-ht2810.4HTR1A, DRD5, DRD1
24aripiprazole28 49 44 11 2414.4DRD4, DRD3, DRD1, HTR1A, DRD5
25ziprasidone49 28 44 1113.4DRD4, DRD3, DRD5, HTR1A, DRD1
26apomorphine44 28 1112.4DRD1, DRD3, HTR1A, DRD4, DRD5
27quetiapine44 49 28 11 2414.4DRD1, DRD3, DRD4, DRD5, HTR1A
28risperidone28 44 49 59 11 2415.4DRD4, DRD1, DRD3, HTR1A
29chlorpromazine44 28 49 1113.4DRD4, DRD3, DRD5, DRD1, HTR1A
30bromocriptine28 44 1112.4HTR1A, DRD5, DRD4, DRD3, DRD1
31olanzapine49 44 28 11 2414.4DRD3, DRD4, DRD5, DRD1, HTR1A
32sulpiride44 28 1112.4DRD1, DRD4, DRD3
33methylphenidate44 49 1112.4DRD1, DRD4, DRD5
34levodopa44 1111.4DRD5, DRD4, DRD3, DRD1, HTR1A
35clozapine44 28 49 1113.4DRD3, DRD5, DRD4, DRD1, HTR1A
36haloperidol44 28 2 49 1114.4DRD5, DRD4, DRD3, DRD1, HTR1A
37maoa4410.3TPH2, HTR1A, DRD4
38cocaine44 1111.3DRD3, DRD1, S100B, DRD4, PNOC
39catecholamine4410.3DRD3, S100B, DRD1, DRD4, DRD5, ENO2
40thioridazine28 44 49 1113.3DRD5, DRD1, HTR1A
41opiate4410.2DRD3, INA, DRD1, PNOC
42quinpirole44 2811.2DRD4, DRD3, DRD1
435-hydroxytryptamine4410.2TPH2, ENO2, PNOC, DRD4, HTR1A
44ketanserin28 4411.2HTR1A, DRD5
45potassium44 11 2412.1KCNK18, S100B, DRD3, PNOC, ENO2, DRD4
46norepinephrine44 11 2412.0DRD4, DRD1, PNOC, HTR1A, S100B, DRD3
47dopamine44 28 11 2413.0ENO2, DRD1, S100B, DRD5, DRD4, PNOC
48gaba4410.0S100B, DRD1, ENO2, DRD4, PNOC
49adenylate449.8DRD4, ENO2, PNOC, DRD1, S100B, HTR1A
50calcium44 49 11 2412.0MMP17, PNOC, DRD3, DRD1, S100B, DRD4

GO Terms for genes affiliated with Migraine Without Aura

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7MMP17, DRD5, DRD4, DRD3, DRD1, HTR1A

Biological processes related to Migraine Without Aura according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.6DRD5, DRD1
2response to histamineGO:03477610.5DRD3, DRD4
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.5DRD3, DRD1
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD3
5dopamine metabolic processGO:04241710.5DRD1, DRD3, DRD4
6regulation of dopamine metabolic processGO:04205310.5DRD4, DRD1, HTR1A
7adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3, DRD5
8cellular response to catecholamine stimulusGO:07187010.5DRD1, DRD5
9behavioral response to cocaineGO:04814810.5DRD4, DRD3, DRD1
10positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5DRD5, DRD1
11behavioral fear responseGO:00166210.5HTR1A, DRD1, DRD4
12synaptic transmission, dopaminergicGO:00196310.4DRD5, DRD4, DRD3, DRD1
13response to amphetamineGO:00197510.4DRD1, DRD3, DRD4, DRD5
14phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD1, DRD5
15response to glucocorticoid stimulusGO:05138410.3TPH2, TNF, S100B
16long term synaptic depressionGO:06029210.3DRD5, DRD1
17arachidonic acid secretionGO:05048210.3DRD4, DRD3
18cellular calcium ion homeostasisGO:00687410.3DRD5, DRD4, DRD3
19negative regulation of protein secretionGO:05070910.2DRD3, DRD4
20prepulse inhibitionGO:06013410.0DRD3, DRD1

Molecular functions related to Migraine Without Aura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3
2dopamine bindingGO:03524010.1DRD5, DRD4, DRD3, DRD1
3dopamine neurotransmitter receptor activityGO:00495210.1DRD1, DRD4, DRD5
4dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.0DRD5, DRD1

Products for genes affiliated with Migraine Without Aura

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Migraine Without Aura

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet