MCID: MLD013
MIFTS: 26

Mild Hemophilia a malady

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Mild Hemophilia a

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Mild Hemophilia a:

Name: Mild Hemophilia a 51
Mild Hereditary Factor Viii Deficiency Disease 65
 
Mild Factor Viii Deficiency 51

Characteristics:

Orphanet epidemiological data:

51
mild factor viii deficiency:
Inheritance: X-linked recessive; Age of onset: Infancy,Neonatal

Classifications:



External Ids:

Orphanet51 169808
ICD10 via Orphanet28 D66
UMLS via Orphanet66 C0272324
UMLS65 C0272324

Summaries for Mild Hemophilia a

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MalaCards based summary: Mild Hemophilia a, also known as mild hereditary factor viii deficiency disease, is related to prostatitis and glossopharyngeal neuralgia. An important gene associated with Mild Hemophilia a is F8 (Coagulation Factor VIII), and among its related pathways are Collagen biosynthesis and modifying enzymes and Platelet activation, signaling and aggregation. Affiliated tissues include bone, lung and liver.

Related Diseases for Mild Hemophilia a

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Diseases in the Mild Hemophilia a family:

Mild Hemophilia B

Diseases related to Mild Hemophilia a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis10.1
2glossopharyngeal neuralgia10.1
3acquired hemophilia a10.0F10, F8
4stargardt disease 110.0
5prostate cancer10.0
6renal cell carcinoma10.0
7hemochromatosis10.0
8stargardt disease10.0
9pulmonary hypertension10.0
10end stage renal failure10.0
11pancreatic ductal adenocarcinoma10.0
12primary biliary cirrhosis10.0
13sleep apnea10.0
14obstructive sleep apnea10.0
15acute hemorrhagic conjunctivitis10.0
16corpus luteum cyst10.0
17congenital toxoplasmosis10.0
18urethritis10.0
19cervicitis10.0
20adenocarcinoma10.0
21thoracic outlet syndrome10.0
22aortic aneurysm10.0
23pancreatitis10.0
24hemangioblastoma10.0
25conjunctivitis10.0
26tauopathy10.0
27thyroiditis10.0
28abdominal aortic aneurysm10.0
29neuronitis10.0
30learning disability10.0
31intracranial hypertension10.0
32fasciitis10.0
33toxoplasmosis10.0
34neonatal hemochromatosis10.0
35clear cell renal cell carcinoma10.0
36eosinophilic fasciitis10.0
37growth hormone deficiency10.0
38isolated growth hormone deficiency10.0
39intellectual disability10.0
40aneurysm10.0
41solitary fibrous tumor10.0
42type 2n von willebrand disease9.8F8, VWF
43tyrobp-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy9.8F8, VWF
44acral dysostosis dyserythropoiesis syndrome9.8F8, VWF
45type 2m von willebrand disease9.8F8, VWF
46von willibrand disease, type 39.8F8, VWF
47dysthymic disorder9.8F8, VWF
48factor v deficiency9.8F10, VWF
49blood platelet disease9.8F8, VWF
50skeletal muscle regeneration9.8F8, VWF

Graphical network of the top 20 diseases related to Mild Hemophilia a:



Diseases related to mild hemophilia a

Symptoms for Mild Hemophilia a

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Drugs & Therapeutics for Mild Hemophilia a

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Drugs for Mild Hemophilia a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Factor VIIIPhase 4, Phase 2, Phase 1272
2Pharmaceutical SolutionsPhase 47004
3
Oprelvekinapproved, investigationalPhase 216145941-26-0
Synonyms:
145941-26-0
AGIF
Adipogenesis inhibitory factor
D05266
IL-11
 
Interleukin-11 precursor
Neumega
Neumega (TN)
Oprelvekin
Oprelvekin (USAN/INN)
Oprelvekin (genetical recombination)
Oprelvekin (genetical recombination) (JAN)
4Deamino Arginine VasopressinPhase 2, Phase 168
5CoagulantsPhase 11042
6VasopressinsPhase 1260
7Natriuretic AgentsPhase 11403
8HemostaticsPhase 11082
9Arginine VasopressinPhase 1264
10arginineNutraceuticalPhase 1364
11Protease Inhibitors4558
12Serine Proteinase Inhibitors705
13Thromboplastin54
14Lipoprotein-associated coagulation inhibitor7
15Thrombin269
16Anticoagulants1760
17Antithrombins574
18Factor Xa Inhibitors315
19HIV Protease Inhibitors4558
20Fibrinolytic Agents1567
21Antithrombin III563
22serineNutraceutical770

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Post Marketing Study in Haemophilia B Patients Using Nonafact® (Human Coagulation Factor IX)CompletedNCT00139828Phase 4
2High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With InhibitorsCompletedNCT00571584Phase 4
3Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle ArthropathyCompletedNCT00638001Phase 4
4Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia BCompletedNCT01027364Phase 3
5Efficacy and Safety of IL-11 in DDAVP UnresponsiveCompletedNCT00994929Phase 2
6Characterization of Laboratory Response to DDAVP in Adult Hemophilia A CarriersEnrolling by invitationNCT02506023Phase 1
7Allogenic Bone Marrow Derived Mesenchymal Stem Cell Therapy in Cases of HemophiliaNot yet recruitingNCT02108132Phase 1
8Tissue Factor Pathway Inhibitor (TFPI) and Haemorrhagic Manifestations in Haemophilia A and B PatientsCompletedNCT02540187
9Observational Registry of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With InhibitorsCompletedNCT00703911
10Project to Update the Study of Congenital Haemophilia in SpainCompletedNCT01959555
11Females With Severe or Moderate Hemophilia A or B: an International Multi-center StudyCompletedNCT00936312
12Gait Evaluation in Haemophiliac PatientsCompletedNCT00824798
13Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF - A Swedish Cohort StudyActive, not recruitingNCT02740413
14Inhibitor Development in Patients With Hemophilia A Undergoing SurgeryActive, not recruitingNCT01571934
15Platelet Function in Patients With Hemophilia AEnrolling by invitationNCT02093065
16Non Neutralizing Antibodies: Prevalence and CharacterizationWithdrawnNCT01541527

Search NIH Clinical Center for Mild Hemophilia a

Genetic Tests for Mild Hemophilia a

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Anatomical Context for Mild Hemophilia a

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MalaCards organs/tissues related to Mild Hemophilia a:

33
Bone, Lung, Liver

Animal Models for Mild Hemophilia a or affiliated genes

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Publications for Mild Hemophilia a

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Articles related to Mild Hemophilia a:

(show all 36)
idTitleAuthorsYear
1
Detection of hepatitis D virus RNA carrying large fragment deletions in patients with severe hepatitis B/D receiving oral antiviral therapy. (25612072)
2015
2
Tularemia among free-ranging mice without infection of exposed humans, Switzerland, 2012. (25531919)
2015
3
Nanoluciferase as a novel quantitative protein fusion tag: Application for overexpression and bioluminescent receptor-binding assays of human leukemia inhibitory factor. (25179300)
2014
4
Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population. (25129243)
2014
5
IL-1I^ increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells. (24974860)
2014
6
Cerebral venous thrombosis masquerading as hemicrania continua. (25387634)
2014
7
XRCC1 codon 280 polymorphism and susceptibility to lung cancer: a meta-analysis of the literatures. (23733202)
2013
8
Diagnostic discussion. Melanoacanthoma. (23513945)
2013
9
Does medical specialty influence the treatment of asymptomatic carotid stenosis? a Belgian multidisciplinary survey. (21460764)
2011
10
Challenges for cerebrovascular disease. (21188249)
2010
11
Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population]. (21154329)
2010
12
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. (20154720)
2010
13
Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. (20173668)
2010
14
Novel mutation in the NHLRC1 gene in a Malian family with a severe phenotype of Lafora disease. (19322595)
2009
15
Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking. (19191728)
2009
16
Bioactivation of lumiracoxib by peroxidases and human liver microsomes: identification of multiple quinone imine intermediates and GSH adducts. (19063590)
2009
17
Protein kinase B: signalling roles and therapeutic targeting. (17952368)
2008
18
Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. (17952071)
2007
19
Cytochrome C oxidase III interacts with hepatitis B virus X protein in vivo by yeast two-hybrid system. (15334674)
2004
20
Generalized bullous impetigo in a neonate. (15575854)
2004
21
Mdr-1 ribozyme in the reversal of multidrug resistance in human ovarian cancer]. (14575561)
2003
22
Structure, binding, and antagonists in the IL-4/IL-13 receptor system. (12421669)
2002
23
Diplopia and enophthalmos after surgical repair of blowout fracture. (12029579)
2002
24
Ocular Manifestation of Mucopolysaccharidosis I-S (Scheie's Syndrome)]. (12447720)
2002
25
The fetal origins of osteoporotic fracture. (11960204)
2002
26
A very rare cause of intestinal pseudoobstruction: familial visceral myopathy type IV. (10914974)
2000
27
Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma. (10875487)
2000
28
Regulation of reactive oxygen species by nerve growth factor but not Bcl-2 as a novel mechanism of protection of PC12 cells from superoxide anion-induced death. (10220589)
1999
29
Molecular and neuroanatomical mechanisms of sleep-wakefulness regulation by prostaglandins D2 and E2]. (10202759)
1998
30
Rapid enlargement of a choledochal cyst: antenatal diagnosis and delayed primary excision. (9639632)
1998
31
Phospholipase C gamma 1 overexpression and activation induced by interferon beta in human T lymphocytes: an ISGF3-independent response. (9325014)
1997
32
Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis. (8028036)
1994
33
Ultrastructural and cytochemical study of the odontoclasts in physiologic root resorption of human deciduous teeth. (1328451)
1992
34
The constitutive 7-ethoxycoumarin 0-deethylase of human placental microsomes: relationship to the intermediary steps in steroid aromatization. (2304374)
1990
35
Effects of thorotrast on humoral antibody, viral multiplication, and interferon during infection with St. Louis encephalitis virus in mice. (5111885)
1971
36
Basal cell epithelioma in a thermal burn scar. (5423393)
1970

Variations for Mild Hemophilia a

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Expression for genes affiliated with Mild Hemophilia a

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Search GEO for disease gene expression data for Mild Hemophilia a.

Pathways for genes affiliated with Mild Hemophilia a

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GO Terms for genes affiliated with Mild Hemophilia a

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Cellular components related to Mild Hemophilia a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.3F10, F8

Biological processes related to Mild Hemophilia a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00075969.4F10, F8
2post-translational protein modificationGO:00436879.3F10, F8

Sources for Mild Hemophilia a

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet