Aliases & Classifications for Milk Allergy

MalaCards integrated aliases for Milk Allergy:

Name: Milk Allergy 12 14
Milk Hypersensitivity 41 69
Milk Allergic Reaction 12
Allergy Milk 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4376
MeSH 41 D016269
UMLS 69 C0079840

Summaries for Milk Allergy

Disease Ontology : 12 A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

MalaCards based summary : Milk Allergy, also known as milk hypersensitivity, is related to goat milk allergy and cow milk allergy. An important gene associated with Milk Allergy is CD79A (CD79a Molecule), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Soy Bean and Caseins have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and testes, and related phenotype is endocrine/exocrine gland.

Wikipedia : 72 Milk allergy is an adverse immune reaction to one or more proteins in cow\'s milk. When allergy symptoms... more...

Related Diseases for Milk Allergy

Diseases related to Milk Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 goat milk allergy 34.3 CSN1S1 LALBA
2 cow milk allergy 33.0 CD79A IL10 IL5 RNASE3
3 eosinophilic gastroenteritis 29.8 IL5 RNASE3
4 sinusitis 29.5 IL5 RNASE3
5 egg allergy 29.4 IL4 IL5
6 dermatitis 29.3 IL4 IL5 RNASE3
7 ige responsiveness, atopic 28.9 CSN1S1 IL10 IL4 IL5 RNASE3
8 tetanus 28.8 CD79A IL10 IL4 IL5
9 gastroenteritis 28.8 IL10 IL4 IL5 RNASE3
10 dermatitis, atopic 28.7 CSN1S1 IL10 IL4 IL5 RNASE3
11 inflammatory bowel disease 28.4 CD79A IL10 IL4 IL5
12 asthma 28.0 CD79A IL10 IL4 IL5 RNASE3
13 allergic hypersensitivity disease 27.9 CSN1S1 IL10 IL4 IL5 LALBA RNASE3
14 lactose intolerance 11.3
15 heiner syndrome 11.1
16 sporotrichosis 10.4 CD79A IL10
17 mycetoma 10.4 CSN1S1 IL10
18 chronic graft versus host disease 10.4 CD79A IL10
19 clonorchiasis 10.3 CD79A IL10
20 taeniasis 10.3 CD79A IL10
21 chronic interstitial cystitis 10.3 CD79A RNASE3
22 anisakiasis 10.3 CD79A RNASE3
23 maxillary sinusitis 10.3 CD79A RNASE3
24 tuberculoid leprosy 10.3 IL10 TGFB2
25 lipid-rich carcinoma 10.3 CSN2 LALBA
26 lipoid nephrosis 10.2 CD79A IL10
27 henoch-schoenlein purpura 10.2 CD79A RNASE3
28 tropical endomyocardial fibrosis 10.2 IL10 IL4
29 hyperlucent lung 10.2 IL10 IL4
30 tungiasis 10.2 IL10 IL4
31 endomyocardial fibrosis 10.2 IL10 IL4
32 collagenous colitis 10.2 CD79A RNASE3
33 retinitis pigmentosa 22 10.2 IL10 IL4
34 baylisascariasis 10.2 IL10 IL4
35 chronic maxillary sinusitis 10.2 CD79A RNASE3
36 beta-lactam allergy 10.2 IL10 IL4
37 q fever 10.2 CD79A IL10
38 parasitic ichthyosporea infectious disease 10.2 CD79A IL4
39 congenital hypogammaglobulinemia 10.2 CD79A IL4
40 buruli ulcer 10.2 IL10 IL4
41 rhinosporidiosis 10.2 CD79A IL4
42 poliomyelitis 10.2 IL10 IL4
43 immunodeficiency with hyper-igm, type 1 10.2 CD79A IL4
44 primary systemic mycosis 10.2 IL10 IL4
45 blepharoconjunctivitis 10.2 IL4 RNASE3
46 bardet-biedl syndrome 15 10.1 IL10 IL4
47 microscopic colitis 10.1 CD79A IL4
48 celiac disease 1 10.1 CD79A IL10 LALBA
49 eales disease 10.1 IL10 IL4
50 vulvovaginal candidiasis 10.1 CD79A IL4

Graphical network of the top 20 diseases related to Milk Allergy:



Diseases related to Milk Allergy

Symptoms & Phenotypes for Milk Allergy

MGI Mouse Phenotypes related to Milk Allergy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CSN2 CSN3 IL10 IL4 LALBA TGFB2

Drugs & Therapeutics for Milk Allergy

Drugs for Milk Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Soy Bean Nutraceutical Phase 4
2 Caseins Phase 2, Phase 3
3 Acidophilus Nutraceutical Phase 2, Phase 3
4
Omalizumab Approved, Investigational Phase 2,Early Phase 1 242138-07-4
5 Vaccines Phase 2
6 Chelating Agents Phase 2
7 Anti-Allergic Agents Phase 2,Early Phase 1
8 Anti-Asthmatic Agents Phase 2,Early Phase 1
9 Antibodies Phase 2,Phase 1
10 Antibodies, Monoclonal Phase 2
11 Immunoglobulins Phase 2,Phase 1
12 Respiratory System Agents Phase 2,Early Phase 1
13 Immunoglobulin E Phase 1, Phase 2
14 Whey Protein Nutraceutical Phase 2
15
Calcium Carbonate Approved, Investigational 471-34-1
16
Menthol Approved 2216-51-5 16666
17
Menadione Approved, Nutraceutical 58-27-5 4055
18
Phytonadione Approved, Investigational, Nutraceutical 84-80-0 5284607 4812
19 Calcium, Dietary
20 Complement System Proteins
21 Dermatologic Agents
22 Antifibrinolytic Agents
23 Coagulants
24 Hemostatics
25 Micronutrients
26 Trace Elements
27 Vitamin K 2
28 Vitamin MK 7
29 Vitamins
30 Flax Nutraceutical
31 Menaquinone Nutraceutical
32 naphthoquinone Nutraceutical
33 Vitamin K Nutraceutical

Interventional clinical trials:

(show top 50) (show all 92)

# Name Status NCT ID Phase Drugs
1 Safety of Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
2 Growth, Safety and Tolerance of a Rice Protein Hydrolysate Formula in Infants With Cow's Milk Protein Allergy Recruiting NCT02405923 Phase 4
3 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Recruiting NCT01966640 Phase 4
4 Parmigiano-Reggiano Cheese as a Possible Strategy to Acquire Oral Tolerance in Children With Cow's Milk Allergy Unknown status NCT02081651 Phase 3
5 Microbiota as Potential Target for Food Allergy Unknown status NCT02087930 Phase 2, Phase 3
6 Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy Completed NCT02351531 Phase 3
7 Evaluation of the Hypoallergenicity of an Extensively Hydrolyzed Formula Recruiting NCT02711163 Phase 3
8 Improving the Safety of Oral Immunotherapy in Cow's Milk Allergy Not yet recruiting NCT02216175 Phase 2, Phase 3
9 Epigenetic Effects Elicited By Lactobacillus GG In Children With Cow's Milk Allergy Unknown status NCT02062476 Phase 2
10 Evaluation of the Efficacy of a New Infant Formula in Subjects With Cow's Milk Allergy Unknown status NCT02149134 Phase 2
11 Therapeutic Effect of Chinese Herbal Medicine on Food Allergy Unknown status NCT00602160 Phase 2 FAHF-2 (TM)
12 Milk ALLERGY ELIMINATION THROUGH NAET® (Nambudripad's Allergy Elimination Techniques). Completed NCT00328731 Phase 1, Phase 2
13 OIT and Xolair® (Omalizumab) in Cow's Milk Allergy Completed NCT01157117 Phase 2 Milk powder
14 Study of Milk Allergy and Tolerance in Children Completed NCT00778258 Phase 2
15 A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy Completed NCT00465569 Phase 1, Phase 2 cow's milk powder
16 Free Amino Acid-based Formula to Treat Children Cow's Milk Protein Allergy Completed NCT02536482 Phase 2
17 The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy Completed NCT00732654 Phase 1, Phase 2 Milk Protein Extract Immunotherapy goal of 4mg/day;Milk Protein Extract Immunotherapy goal of 7mg/day;Milk Powder Immunotherapy goal dose 2000 mg/day;Milk Powder Immunotherapy goal dose 1000mg/day
18 Tolerance of Infants With Cow's Milk Protein Allergy to Extensively Hydrolyzed Rice Protein or Casein Infant Formulas Completed NCT01909661 Phase 2
19 The Effect of Baked Milk on Cow's Milk Allergy Recruiting NCT02738060 Phase 2
20 Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy Recruiting NCT02414243 Phase 2
21 A Clinical Study to Investigate the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth, Safety and Tolerance in Healthy Term Infants Recruiting NCT03062761 Phase 2
22 Efficacy and Safety of Viaskin Milk in Children With IgE-Mediated Cow's Milk Allergy Active, not recruiting NCT02223182 Phase 1, Phase 2
23 Milk Patch for Eosinophilic Esophagitis Active, not recruiting NCT02579876 Phase 2 Viaskin Milk 500 mcg;Viaskin Placebo
24 Impact of Infant Formula on Resolution of Cow's Milk Allergy Terminated NCT02719405 Phase 2
25 Study to Identify Non-Invasive Markers of Gastrointestinal Allergy Completed NCT00272818 Phase 1
26 Baked Milk Oral Immunotherapy for Cow's Milk Allergy Enrolling by invitation NCT03462030 Phase 1 Baked non-fat cow's milk powder;Placebo: Tapioca Powder
27 Hypoallergenicity To Substitutive Formulas In Children With Cow's Milk Allergy Unknown status NCT02144428
28 Oral Tolerance in Cow’s Milk Allergy in the Infant Unknown status NCT00298376
29 Cow's Milk Allergy in Infants With Obstructive Sleep Apnea (OSA) Unknown status NCT00659854
30 Effect Of Lactobacillus GG on Atopic March Unknown status NCT01891916
31 Nutrition in Children With Food Allergy Unknown status NCT01583907 Early Phase 1
32 Young Adults With Life Threatening Cow's Milk Allergy: Risks of Decrease Bone Mineralization and Methods of Calcium Supplementation Unknown status NCT01930266
33 Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients Unknown status NCT01968278
34 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
35 The Influence of Probiotics on the Immunologic Response to Vaccinations in Infants Unknown status NCT00645996
36 Prevention of Cow's Milk Allergy in Children Completed NCT00792090
37 Effect of Therapy With Aminoacid Based Formula Versus Hydrolyzed Whey Proteins in Children With Cow's Milk Allergy Completed NCT02379598
38 Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy Completed NCT01622426
39 A Growth and Hypoallergenicity Study of a New Formula for Infants With Cow Milk Allergy Completed NCT00664768
40 Cow's Milk Allergy and Functional Gastrointestinal Disorders Completed NCT01901380
41 Oral Immunotherapy in Cow's Milk Allergy (CMA) in Children : "Petit Lait" Study Completed NCT02465905
42 Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy Completed NCT02779881
43 Effects of Different Dietary Regimens on Tolerance Acquisition in Children With Cow's Milk Allergy Completed NCT01634490
44 An Interventional Study of Milk Allergy Completed NCT00578656 Early Phase 1
45 Camel's Milk as a Safe Alternative in Cow's Milk Allergy Completed NCT01223885
46 Formula for Children With Cow's Milk Allergy Completed NCT02317952
47 Tolerability and Safety of An Infant Formula Completed NCT00938483
48 Specific Oral Tolerance Induction to Cow's Milk Allergy Completed NCT01199484
49 Polymerized Beta-lactoglobulin Comparative Immunoreactivity Completed NCT01589731
50 Isomil Post Marketing Observational Study Completed NCT01809951

Search NIH Clinical Center for Milk Allergy

Cochrane evidence based reviews: milk hypersensitivity

Genetic Tests for Milk Allergy

Anatomical Context for Milk Allergy

MalaCards organs/tissues related to Milk Allergy:

38
Colon, Small Intestine, Testes, T Cells, Bone, B Cells, Skin

Publications for Milk Allergy

Articles related to Milk Allergy:

(show top 50) (show all 198)
# Title Authors Year
1
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
2018
2
Elevated serum adipsin may predict unsuccessful treatment for cows' milk allergy but other biomarkers do not. ( 29028118 )
2018
3
Shift from IgE-mediated cow's milk allergy to food protein induced enterocolitis syndrome in two infants. ( 29444343 )
2018
4
Correction to: Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. ( 29416848 )
2018
5
Bodybuilding protein supplements and cow's milk allergy in adult. ( 29350021 )
2018
6
Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients. ( 29408543 )
2018
7
PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention. ( 29079360 )
2018
8
Tolerability and palatability of donkey's milk in children with cow's milk allergy. ( 29392769 )
2018
9
Basophil activation test in a case report of cow's milk allergy may reveal a non-IgE mediated mechanism. ( 29369413 )
2018
10
The global impact of the DRACMA guidelines cow's milk allergy clinical practice. ( 29308116 )
2018
11
Randomized Trial of a Yogurt-type Amino Acid-based Formula in Infants and Children With Severe Cow's Milk Allergy. ( 29095347 )
2018
12
Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study. ( 29393170 )
2018
13
Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization. ( 27826960 )
2017
14
Altered miR-193a-5p expression in children with cow's milk allergy. ( 28857182 )
2017
15
Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy. ( 28597347 )
2017
16
Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial. ( 29234055 )
2017
17
Evidence for Involvement of IL-9 and IL-22 in Cows' Milk Allergy in Infants. ( 28934137 )
2017
18
Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age. ( 28720381 )
2017
19
An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care. ( 28948011 )
2017
20
Long-term outcomes following baked milk-containing diet for IgE-mediated milk allergy. ( 28583481 )
2017
21
Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy. ( 29149860 )
2017
22
Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study. ( 28459985 )
2017
23
Immunotherapy for cow's milk allergy. ( 28825866 )
2017
24
Accuracy of serum IgE concentrations and papule diameter in the diagnosis of cow's milk allergy. ( 28963879 )
2017
25
Natural history of immunoglobulin E-mediated cow's milk allergy in a population of Argentine children. ( 28737860 )
2017
26
Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants. ( 28698533 )
2017
27
Gastrointestinal Symptoms of Food Challenge-Proven Non-Ige Cow's Milk Allergy are Dissipated by Early School Age. ( 28922259 )
2017
28
Is a slow-progression baked milk protocol of oral immunotherapy always a safe option for children with cow's milk allergy? A randomized controlled trial. ( 28875570 )
2017
29
Cost-effectiveness of using an extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in the US. ( 29098889 )
2017
30
A History of Cow's Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren. ( 28715821 )
2017
31
Prognostic accuracy of clinical signs and diagnostic tests in cow's milk allergy in newborns. ( 28416249 )
2017
32
The Efficacy of Oral Immunotherapy in Patients with Cow's Milk Allergy. ( 28732431 )
2017
33
Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited. ( 29270244 )
2017
34
Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy. ( 29031891 )
2017
35
Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy. ( 28414061 )
2017
36
Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review. ( 28516451 )
2017
37
Preventive effects of royal jelly against anaphylactic response in a murine model of cow's milk allergy. ( 28982287 )
2017
38
Association between Caesarean Delivery and Isolated Doses of Formula Feeding in Cow Milk Allergy. ( 28787733 )
2017
39
Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. ( 28852472 )
2017
40
Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells. ( 29033945 )
2017
41
Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies. ( 28679035 )
2017
42
Epigenetic features of FoxP3 in children with cow's milk allergy. ( 27525046 )
2016
43
Clinical and laboratory 2-year outcome of oral immunotherapy in patients with cow's milk allergy. ( 26482941 )
2016
44
Cows Milk Allergy: A Cohort of Patients from a University Hospital. ( 27685484 )
2016
45
Febrile attacks triggered by milk allergy in an infant with mevalonate kinase deficiency. ( 27387687 )
2016
46
Human milk oligosaccharides and development of cow's milk allergy in infants. ( 27702672 )
2016
47
Cow's Milk Allergy Prescribing Is Influenced by Regional and National Guidance. ( 26628440 )
2016
48
Cow's Milk Allergy: the Relevance of IgE. ( 26540507 )
2016
49
Role of specific IgE to I^-lactoglobulin in the gastrointestinal phenotype of cow's milk allergy. ( 26909103 )
2016
50
Yogurt in the Treatment of I^-Lactoglobulin-Induced Gastrointestinal Cow's Milk Allergy. ( 27763864 )
2016

Variations for Milk Allergy

Expression for Milk Allergy

Search GEO for disease gene expression data for Milk Allergy.

Pathways for Milk Allergy

Pathways related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 IL10 IL4 IL5 RNASE3
2
Show member pathways
12.32 IL10 IL4 IL5 TGFB2
3
Show member pathways
12.19 IL10 IL4 IL5
4
Show member pathways
12.09 IL10 IL4 IL5
5
Show member pathways
12.02 IL10 IL4 TGFB2
6
Show member pathways
11.88 IL10 IL4 IL5
7 11.55 CSN2 IL4 IL5
8 11.52 CD79A IL10 IL4 IL5
9 11.51 IL10 IL4 IL5
10 11.38 IL10 IL4 IL5
11 11.21 IL10 IL4 IL5
12
Show member pathways
11.15 IL10 TGFB2
13 11.1 IL4 IL5
14 11.08 IL4 IL5
15 10.97 IL10 IL4 IL5
16 10.96 IL10 IL4 IL5
17 10.85 IL10 IL4 IL5
18 10.75 IL10 IL4 IL5 TGFB2
19 10.74 IL4 TGFB2
20 10.74 IL10 IL4 IL5 TGFB2
21 10.21 IL4 IL5 TGFB2

GO Terms for Milk Allergy

Cellular components related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CSN2 CSN3 IL10 IL4 IL5 LALBA
2 extracellular region GO:0005576 9.28 CSN1S1 CSN2 CSN3 IL10 IL4 IL5

Biological processes related to Milk Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 IL10 IL4 IL5 TGFB2
2 defense response to bacterium GO:0042742 9.63 IL10 LALBA RNASE3
3 lactation GO:0007595 9.52 CSN2 CSN3
4 positive regulation of B cell proliferation GO:0030890 9.51 IL4 IL5
5 positive regulation of cell cycle GO:0045787 9.49 IL10 TGFB2
6 B cell proliferation GO:0042100 9.48 CD79A IL10
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL10 IL4
8 B cell differentiation GO:0030183 9.43 CD79A IL10 IL4
9 B cell activation GO:0042113 9.4 CD79A IL4
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
11 type 2 immune response GO:0042092 9.16 IL10 IL4
12 regulation of isotype switching GO:0045191 8.96 IL10 IL4
13 regulation of complement-dependent cytotoxicity GO:1903659 8.62 IL10 TGFB2

Molecular functions related to Milk Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL10 IL4 IL5 TGFB2
2 growth factor activity GO:0008083 8.92 IL10 IL4 IL5 TGFB2

Sources for Milk Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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