MCID: MLL002
MIFTS: 43

Miller Fisher Syndrome malady

Categories: Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Miller Fisher Syndrome

Aliases & Descriptions for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 51 52 42 14 69
Cranial Variant of Guillain-Barré Syndrome 50 56
Miller-Fisher Syndrome 50 56
Cranial Variant of Gbs 50 56
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Fisher's Syndrome 12
Fisher Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
miller-fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
ICD10 33 G61.0
MeSH 42 D019846
NCIt 47 C116958
Orphanet 56 ORPHA98919
MESH via Orphanet 43 D019846
UMLS via Orphanet 70 C0393799
ICD10 via Orphanet 34 G61.0
UMLS 69 C0393799

Summaries for Miller Fisher Syndrome

NIH Rare Diseases : 50 miller-fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of guillain-barré syndrome. it is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. like guillain-barré syndrome, symptoms may be preceded by a viral illness. additional symptoms include generalized muscle weakness and respiratory failure. the majority of individuals with miller-fisher syndrome have a unique antibody that characterizes the disorder. treatment includes intravenous immunoglobulin (ivig) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. last updated: 10/21/2011

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to guillain-barre syndrome and kozlowski warren fisher syndrome, and has symptoms including cerebellar ataxia and ophthalmoplegia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are TRAF Pathway and Immune response NFAT in immune response. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung.

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS : 51 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 11.9
2 kozlowski warren fisher syndrome 11.8
3 bickerstaff brainstem encephalitis 11.4
4 encephalitis 10.4
5 neuropathy 10.3
6 hemangioma of orbit 10.2 CD40LG TNF
7 dermatitis herpetiformis 10.2 CD40LG TNF
8 spotted fever 10.2 CD40LG TNF
9 human immunodeficiency virus infectious disease 10.2 CD40LG TNF
10 uveitis 10.2 CD40LG TNF
11 congenital hypothyroidism 10.2 CD40LG TNF
12 gastroduodenal crohn's disease 10.2 CD40LG TNF
13 dermatomycosis 10.2 CD40LG TNF
14 conduct disorder 10.2 CD40LG TNF
15 pancreatic signet ring cell adenocarcinoma 10.2 CD40LG TNF
16 tularemia 10.2 CD40LG TNF
17 cryptococcosis 10.2 CD40LG TNF
18 cerebellar liponeurocytoma 10.2 CD40LG TNF
19 oral cavity cancer 10.2 CD40LG TNF
20 mineral metabolism disease 10.2 CD40LG TNF
21 hereditary alpha tryptasemia syndrome 10.2 CD40LG TNF
22 conjunctival vascular disease 10.2 CD40LG TNF
23 rickettsialpox 10.2 CD40LG TNF
24 functional gastric disease 10.2 CD40LG TNF
25 ataxia 10.2
26 astrocytoma 10.2 CD40LG TNF
27 powassan encephalitis 10.2 CD40LG TNF
28 benign deep fibrous histiocytoma 10.2 CD40LG TNF
29 endogenous depression 10.2 CD40LG TNF
30 jaw cancer 10.2 CD40LG MAG
31 wound botulism 10.2 CD40LG TNF
32 cannabis dependence 10.2 CD40LG MAG
33 plummer's disease 10.2 CD40LG TNF
34 nerve compression syndrome 10.2 CD40LG MAG
35 dracunculiasis 10.2 CD40LG TNF
36 ovarian cystic teratoma 10.2 CD40LG TNF
37 glomangiosarcoma 10.2 CD40LG MAG
38 radial hypoplasia, triphalangeal thumbs and hypospadias 10.2 CD40LG TNF
39 dentin caries 10.2 CD40LG TNF
40 arteriosclerosis 10.2 CD40LG MAG
41 acinic cell breast carcinoma 10.2 CD40LG TNF
42 tuberculosis 10.2 CD40LG TNF
43 disease of mental health 10.2 CD40LG TNF
44 atrophy of prostate 10.2 CD40LG TNF
45 ethmoid sinus schneiderian papilloma 10.2 CD40LG MAG
46 newcastle disease 10.2 CD40LG TNF
47 facial nerve neoplasm 10.2 CD40LG HMGA2
48 carotenemia 10.2 CD40LG TNF
49 spastic ataxia 7, autosomal dominant 10.2 CD40LG HMGA2
50 immunoglobulin g deficiency 10.2 CD40LG TNF

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:


cerebellar ataxia, ophthalmoplegia

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 3 51-41-2 439260
3
Lenalidomide Approved Phase 3 191732-72-6 216326
4
Bevacizumab Approved, Investigational Phase 3 216974-75-3
5
Fluorouracil Approved Phase 3 51-21-8 3385
6
Levoleucovorin Approved Phase 3 68538-85-2
7
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
8
Ginseng Approved, Nutraceutical Phase 3 50647-08-0
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
11 Analgesics Phase 3
12 Antidepressive Agents Phase 3
13 Dopamine Agents Phase 3
14 Duloxetine Hydrochloride Phase 3
15 Neurotransmitter Agents Phase 3
16 Neurotransmitter Uptake Inhibitors Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Psychotropic Drugs Phase 3
19
Serotonin Phase 3 50-67-9 5202
20 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
21 Antibodies Phase 3
22 Immunoglobulins Phase 3
23 Angiogenesis Inhibitors Phase 3
24 Angiogenesis Modulating Agents Phase 3
25 Anti-Bacterial Agents Phase 3
26 Anti-Infective Agents Phase 3
27 Epoetin alfa Phase 3 113427-24-0
28 Hematinics Phase 3
29 Immunosuppressive Agents Phase 3
30 Antibodies, Monoclonal Phase 3
31 Antidotes Phase 3
32 Antimetabolites Phase 3
33 Antimetabolites, Antineoplastic Phase 3
34 Bone Density Conservation Agents Phase 3
35 Calcium, Dietary Phase 3
36 Endothelial Growth Factors Phase 3
37 Immunoglobulin G Phase 3
38 Micronutrients Phase 3
39 Mitogens Phase 3
40 Protective Agents Phase 3
41 Trace Elements Phase 3
42 Vitamin B Complex Phase 3
43 Vitamins Phase 3
44 Cola Nutraceutical Phase 3
45 Folate Nutraceutical Phase 3
46 Vitamin B9 Nutraceutical Phase 3
47
Paclitaxel Approved, Vet_approved 33069-62-4 36314
48 Albumin-Bound Paclitaxel
49 Antimitotic Agents
50 Antineoplastic Agents, Phytogenic

Interventional clinical trials:


id Name Status NCT ID Phase
1 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
2 Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00489411 Phase 3
3 Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome and Anemia Active, not recruiting NCT00843882 Phase 3
4 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3
5 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
6 Acute Pain Caused by Paclitaxel in Patients With Cancer Completed NCT00860041
7 International Guillain-Barré Syndrome Outcome Study Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

MalaCards organs/tissues related to Miller Fisher Syndrome:

39
Eye, Brain, Lung, Testes, B Cells, Breast, Dorsal Root Ganglion

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 270)
id Title Authors Year
1
A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence? ( 28090073 )
2017
2
Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. ( 28067631 )
2017
3
Miller Fisher syndrome presenting as palate paralysis. ( 27609285 )
2016
4
Pediatric Miller Fisher Syndrome Complicating an Epstein-Barr Virus Infection. ( 27460528 )
2016
5
A case of miller fisher syndrome associated with preceding herpes zoster ophthalmicus. ( 27875624 )
2016
6
Miller Fisher Syndrome: A Case Report Highlighting Heterogeneity of Clinical Features and Focused Differential Diagnosis. ( 27437164 )
2016
7
Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology? ( 27239355 )
2016
8
Late Presentation of Ataxia, Areflexia, and Electrophysiological Abnormalities as Part of Miller Fisher Syndrome: Case Report. ( 27928406 )
2016
9
Posterior reversible encephalopathy syndrome following immunoglobulin therapy in a patient with Miller-Fisher syndrome. ( 26929465 )
2016
10
An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. ( 27597525 )
2016
11
Overlap of Myasthenia Gravis and Miller Fisher Syndrome. ( 27432103 )
2016
12
Miller Fisher syndrome. ( 27737870 )
2016
13
Takotsubo cardiomyopathy associated with Miller-Fisher syndrome. ( 28040387 )
2016
14
An unusual presentation of Miller Fisher syndrome with optic neuropathy. ( 27554001 )
2016
15
An Overlapping Case of Miller Fisher Syndrome, Bickerstaff's Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome. ( 27974981 )
2016
16
Recurrent Guillain-BarrAc syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis. ( 27084218 )
2016
17
Papilledema in an otherwise clinically typical case of Miller Fisher syndrome. ( 26455984 )
2015
18
Neuro-ophthalmological manifestations in three cases of Miller Fisher syndrome and a brief review of literature. ( 26588640 )
2015
19
Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis. ( 25890931 )
2015
20
Miller-Fisher Syndrome: Is the ataxia central or peripheral? ( 26331046 )
2015
21
A case of Miller Fisher syndrome during preoperative chemotherapy for breast cancer. ( 26629243 )
2015
22
Novel Variant of Miller Fisher Syndrome Occurring With Tumor Necrosis Factor I+ Antagonist Therapy. ( 26551961 )
2015
23
Clinical Features of Miller-Fisher Syndrome in Pregnancy. ( 26697248 )
2015
24
Delayed facial palsy in Miller Fisher syndrome. ( 26277343 )
2015
25
False-Positive Serum Botulism Bioassay in Miller-Fisher Syndrome. ( 26301377 )
2015
26
Atypical Miller Fisher Syndrome with Anisocoria and Rapidly Fluctuating Pupillary Diameter. ( 26380131 )
2015
27
Miller-Fisher syndrome associated with unilateral cerebral white matter lesions. ( 26377988 )
2015
28
A Case of Neuromyelitis Optica Masquerading as Miller Fisher Syndrome. ( 25408664 )
2014
29
Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-BarrAc syndrome in the spectrum of nodo-paranodopathies. ( 24534627 )
2014
30
Taste impairment in Miller Fisher syndrome. ( 25116259 )
2014
31
Miller Fisher syndrome with presynaptic neuromuscular transmission disorder. ( 25300589 )
2014
32
Cerebral infarction 3 weeks after intravenous immunoglobulin for Miller Fisher syndrome: a case report. ( 24661403 )
2014
33
Recurrent pediatric miller fisher syndrome. ( 25160556 )
2014
34
Miller Fisher syndrome related to Orientia tsutsugamushi infection. ( 25065842 )
2014
35
Total internal and external ophthalmoplegia as presenting symptoms of Miller Fisher syndrome. ( 25121494 )
2014
36
Acute Angle-Closure Glaucoma in a Patient With Miller Fisher Syndrome Without Pupillary Dysfunction. ( 25393040 )
2014
37
Posterior reversible encephalopathy syndrome and stroke after intravenous immunoglobulin treatment in Miller-Fisher syndrome/Bickerstaff brain stem encephalitis overlap syndrome. ( 25149206 )
2014
38
Limb motor nerve dysfunction in Miller Fisher syndrome. ( 23521640 )
2013
39
An 85-year-old woman with Miller Fisher syndrome. ( 24353740 )
2013
40
Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oculomotor weakness in Guillain-BarrAc syndrome and Miller Fisher syndrome. ( 23173866 )
2013
41
The effectiveness of immunomodulating treatment on Miller Fisher syndrome: a retrospective analysis of 65 Chinese patients. ( 23781970 )
2013
42
Internal ophthalmoplegia as the initial symptom of Miller-Fisher syndrome. ( 24075583 )
2013
43
A case of atypical Miller Fisher syndrome with negative anti-GQ1b immunoglobulin G and importance of H reflex. ( 24192691 )
2013
44
Postvaccination Miller Fisher syndrome after combined pertussis, diphtheria and tetanus toxoid vaccine. ( 23219950 )
2013
45
Miller Fisher syndrome with positivity of anti-GAD antibodies. ( 24103627 )
2013
46
Miller Fisher syndrome with positivity of anti-GAD antibodies. ( 23253818 )
2013
47
A pediatric case of Miller Fisher syndrome with central involvement. ( 23196382 )
2013
48
Recurrent Miller Fisher Syndrome in Children. ( 24321544 )
2013
49
Miller Fisher syndrome with positivity of anti-GAD antibodies. ( 24094904 )
2013
50
Recurrent Miller Fisher syndrome: clinical and laboratory features. ( 22117529 )
2012

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

GO Terms for Miller Fisher Syndrome

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 CD40LG TNF

Sources for Miller Fisher Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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