MCID: MLL002
MIFTS: 44

Miller Fisher Syndrome

Categories: Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Miller Fisher Syndrome

MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 72 50 51 41 14 69
Cranial Variant of Guillain-Barré Syndrome 49 55
Miller-Fisher Syndrome 49 55
Cranial Variant of Gbs 49 55
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Fisher's Syndrome 12
Fisher Syndrome 55

Characteristics:

Orphanet epidemiological data:

55
miller-fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
ICD10 32 G61.0
MeSH 41 D019846
NCIt 46 C116958
Orphanet 55 ORPHA98919
MESH via Orphanet 42 D019846
UMLS via Orphanet 70 C0393799
ICD10 via Orphanet 33 G61.0
UMLS 69 C0393799

Summaries for Miller Fisher Syndrome

NIH Rare Diseases : 49 Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barré syndrome. The main features are lack of muscle coordination (ataxia), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes. Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome. Treatment includes intravenous immunoglobulin (IVIG), plasmapheresis (a plasma exchange procedure in which the antibodies are removed from the blood) and supportive care. The prognosis is usually good, and in most cases, there is almost complete recovery within 6 months. In rare cases, the syndrome may progress and permanent neurological deficits may be present. Last updated: 10/31/2017

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to guillain-barre syndrome and optic neuritis, and has symptoms including ophthalmoplegia and cerebellar ataxia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are TRAF Pathway and Immune response NFAT in immune response. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain.

NINDS : 50 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

Wikipedia : 72 Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the... more...

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 33.5 CD40LG TNF
2 optic neuritis 30.5 MAG TNF
3 neuritis 30.5 MAG TNF
4 q fever 30.4 CD40LG TNF
5 kozlowski warren fisher syndrome 12.0
6 bickerstaff brainstem encephalitis 11.5
7 encephalitis 10.4
8 trench fever 10.4 CD40LG TNF
9 encephalitozoonosis 10.4 CD40LG TNF
10 rheumatoid lung disease 10.4 CD40LG TNF
11 ataxia and polyneuropathy, adult-onset 10.4
12 neuropathy 10.4
13 central nervous system vasculitis 10.4 CD40LG TNF
14 jejunoileitis 10.4 CD40LG TNF
15 primary systemic mycosis 10.4 CD40LG TNF
16 acute salpingitis 10.4 CD40LG TNF
17 coccidiosis 10.4 CD40LG TNF
18 hemorrhagic fever 10.4 CD40LG TNF
19 pneumocystosis 10.4 CD40LG TNF
20 streptococcal meningitis 10.4 CD40LG TNF
21 spinal cord disease 10.4 CD40LG TNF
22 pustulosis palmaris et plantaris 10.4 CD40LG TNF
23 panuveitis 10.4 CD40LG TNF
24 scrub typhus 10.4 CD40LG TNF
25 lichen disease 10.4 CD40LG TNF
26 chronic salpingitis 10.4 CD40LG TNF
27 plasmodium vivax malaria 10.4 CD40LG TNF
28 critical illness polyneuropathy 10.4 CD40LG TNF
29 middle ear disease 10.4 CD40LG TNF
30 progressive multifocal leukoencephalopathy 10.4 CD40LG TNF
31 hepatitis e 10.3 CD40LG TNF
32 commensal bacterial infectious disease 10.3 CD40LG TNF
33 churg-strauss syndrome 10.3 CD40LG TNF
34 hypersensitivity reaction type iv disease 10.3 CD40LG TNF
35 lymph node disease 10.3 CD40LG TNF
36 hemorrhagic fever with renal syndrome 10.3 CD40LG TNF
37 rheumatic fever 10.3 CD40LG TNF
38 extrinsic cardiomyopathy 10.3 CD40LG TNF
39 chikungunya 10.3 CD40LG TNF
40 exanthem 10.3 CD40LG TNF
41 cogan syndrome 10.3 CD40LG TNF
42 cutaneous lupus erythematosus 10.3 CD40LG TNF
43 legionellosis 10.3 CD40LG TNF
44 idiopathic neutropenia 10.3 CD40LG TNF
45 mixed connective tissue disease 10.3 CD40LG TNF
46 echinococcosis 10.3 CD40LG TNF
47 leptospirosis 10.3 CD40LG TNF
48 mononeuritis multiplex 10.3 CD40LG MAG
49 mononeuritis of upper limb and mononeuritis multiplex 10.3 CD40LG MAG
50 parasitic helminthiasis infectious disease 10.3 CD40LG TNF

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:


ophthalmoplegia, cerebellar ataxia

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
2 International Guillain-Barré Syndrome Outcome Study Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

MalaCards organs/tissues related to Miller Fisher Syndrome:

38
Eye, Heart, Brain, Dorsal Root Ganglion, B Cells, Lung, Testes

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 281)
# Title Authors Year
1
Acute Cerebellar Ataxia Associated with Anti-glutamic Acid Decarboxylase Antibodies Mimicking Miller Fisher Syndrome. ( 29093402 )
2018
2
Miller Fisher syndrome associated with a Zika virus infection. ( 29356259 )
2018
3
Bulbar paralysis associated with Miller-Fisher syndrome and its overlaps in Chinese patients. ( 29124441 )
2018
4
Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. ( 28067631 )
2017
5
Multiple cranial nerve neuropathies, ataxia and, areflexia: Miller Fisher syndrome in a child and review. ( 28214063 )
2017
6
Miller-Fisher syndrome after coronary artery bypass surgery. ( 29297541 )
2017
7
Incomplete Miller-Fisher Syndrome with Advanced Stage Burkitt Lymphoma. ( 28601853 )
2017
8
A Case of Miller Fisher Syndrome and Literature Review. ( 28367386 )
2017
9
Unilateral Oculomotor Nerve Palsy Following Campylobacter Infection: A Mild Form of Miller Fisher Syndrome without Ataxia. ( 28943568 )
2017
10
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. ( 29390338 )
2017
11
A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence? ( 28090073 )
2017
12
Miller Fisher syndrome with sinus arrest. ( 29109855 )
2017
13
MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. ( 28209311 )
2017
14
An unusual presentation of Miller Fisher syndrome with optic neuropathy. ( 27554001 )
2016
15
Takotsubo cardiomyopathy associated with Miller-Fisher syndrome. ( 28040387 )
2016
16
An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. ( 27597525 )
2016
17
Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology? ( 27239355 )
2016
18
Late Presentation of Ataxia, Areflexia, and Electrophysiological Abnormalities as Part of Miller Fisher Syndrome: Case Report. ( 27928406 )
2016
19
A case of miller fisher syndrome associated with preceding herpes zoster ophthalmicus. ( 27875624 )
2016
20
Miller Fisher syndrome. ( 27737870 )
2016
21
Posterior reversible encephalopathy syndrome following immunoglobulin therapy in a patient with Miller-Fisher syndrome. ( 26929465 )
2016
22
An Overlapping Case of Miller Fisher Syndrome, Bickerstaff's Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome. ( 27974981 )
2016
23
Overlap of Myasthenia Gravis and Miller Fisher Syndrome. ( 27432103 )
2016
24
Pediatric Miller Fisher Syndrome Complicating an Epstein-Barr Virus Infection. ( 27460528 )
2016
25
Miller Fisher Syndrome: A Case Report Highlighting Heterogeneity of Clinical Features and Focused Differential Diagnosis. ( 27437164 )
2016
26
Miller Fisher syndrome presenting as palate paralysis. ( 27609285 )
2016
27
Recurrent Guillain-BarrAc syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis. ( 27084218 )
2016
28
Novel Variant of Miller Fisher Syndrome Occurring With Tumor Necrosis Factor I+ Antagonist Therapy. ( 26551961 )
2015
29
Papilledema in an otherwise clinically typical case of Miller Fisher syndrome. ( 26455984 )
2015
30
Delayed facial palsy in Miller Fisher syndrome. ( 26277343 )
2015
31
A case of Miller Fisher syndrome during preoperative chemotherapy for breast cancer. ( 26629243 )
2015
32
Atypical Miller Fisher Syndrome with Anisocoria and Rapidly Fluctuating Pupillary Diameter. ( 26380131 )
2015
33
Miller-Fisher syndrome associated with unilateral cerebral white matter lesions. ( 26377988 )
2015
34
Miller-Fisher Syndrome: Is the ataxia central or peripheral? ( 26331046 )
2015
35
Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis. ( 25890931 )
2015
36
Neuro-ophthalmological manifestations in three cases of Miller Fisher syndrome and a brief review of literature. ( 26588640 )
2015
37
Clinical Features of Miller-Fisher Syndrome in Pregnancy. ( 26697248 )
2015
38
False-Positive Serum Botulism Bioassay in Miller-Fisher Syndrome. ( 26301377 )
2015
39
Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-BarrAc syndrome in the spectrum of nodo-paranodopathies. ( 24534627 )
2014
40
A Case of Neuromyelitis Optica Masquerading as Miller Fisher Syndrome. ( 25408664 )
2014
41
Cerebral infarction 3 weeks after intravenous immunoglobulin for Miller Fisher syndrome: a case report. ( 24661403 )
2014
42
Acute Angle-Closure Glaucoma in a Patient With Miller Fisher Syndrome Without Pupillary Dysfunction. ( 25393040 )
2014
43
Total internal and external ophthalmoplegia as presenting symptoms of Miller Fisher syndrome. ( 25121494 )
2014
44
Recurrent pediatric miller fisher syndrome. ( 25160556 )
2014
45
Miller Fisher syndrome related to Orientia tsutsugamushi infection. ( 25065842 )
2014
46
Posterior reversible encephalopathy syndrome and stroke after intravenous immunoglobulin treatment in Miller-Fisher syndrome/Bickerstaff brain stem encephalitis overlap syndrome. ( 25149206 )
2014
47
Miller Fisher syndrome with presynaptic neuromuscular transmission disorder. ( 25300589 )
2014
48
Taste impairment in Miller Fisher syndrome. ( 25116259 )
2014
49
The effectiveness of immunomodulating treatment on Miller Fisher syndrome: a retrospective analysis of 65 Chinese patients. ( 23781970 )
2013
50
Internal ophthalmoplegia as the initial symptom of Miller-Fisher syndrome. ( 24075583 )
2013

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

GO Terms for Miller Fisher Syndrome

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 CD40LG TNF

Sources for Miller Fisher Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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