MCID: MLL002
MIFTS: 41

Miller Fisher Syndrome malady

Neuronal category

Summaries for Miller Fisher Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Miller-fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of guillain-barré syndrome. it is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. like guillain-barré syndrome, symptoms may be preceded by a viral illness. additional symptoms include generalized muscle weakness and respiratory failure. the majority of individuals with miller-fisher syndrome have a unique antibody that characterizes the disorder. treatment includes intravenous immunoglobulin (ivig) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. last updated: 10/21/2011

MalaCards: Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to n syndrome and guillain-barr� syndrome. An important gene associated with Miller Fisher Syndrome is GSC (goosecoid homeobox). The compounds il-12 and neopterin have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and b cells, and related mouse phenotypes are limbs/digits/tail and behavior/neurological.

Disease Ontology:8 A guillain-barre syndrome that manifests as a descending paralysis. it usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS:44 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:64 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Aliases & Classifications for Miller Fisher Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
cranial variant of guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

miller fisher syndrome 8 44 10 45 61
cranial variant of guillain-barré syndrome 43 49
miller-fisher syndrome 43 49
cranial variant of gbs 43 49
miller-fisher variant of guillain-barre syndrome 8
fisher's syndrome 8
fisher syndrome 49


External Ids:

Disease Ontology8 DOID:12889
MeSH35 D019846
MESH via Orphanet36 D019846
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet58 1767005
UMLS via Orphanet62 C0393799

Related Diseases for Miller Fisher Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to miller fisher syndrome

Clinical Features for Miller Fisher Syndrome

Drugs & Therapeutics for Miller Fisher Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Miller Fisher Syndrome:

33
Brain, Lung, B cells, Dorsal root ganglion, Trigeminal ganglion

Animal Models for Miller Fisher Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Miller Fisher Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6GSC, HMGA2, TNF
2MP:00053868.1GSC, SRF, HMGA2, TNF

Publications for Miller Fisher Syndrome

Sources:
51PubMed
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Articles related to Miller Fisher Syndrome:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
A pediatric case of Miller Fisher syndrome with central involvement. (23196382)
2013
2
Miller Fisher syndrome with positivity of anti-GAD antibodies. (24094904)
2013
3
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. (22447677)
2012
4
Recurrent Miller Fisher syndrome: clinical and laboratory features. (22117529)
2012
5
Miller Fisher syndrome: brief overview and update with a focus on electrophysiological findings. (21631649)
2012
6
Abnormalities of neuromuscular transmission in patients with Miller-Fisher syndrome. (22939779)
2012
7
Bilateral oculomotor synkinesis following Miller Fisher syndrome. (22407534)
2012
8
Miller Fisher syndrome following vaccination. (22109514)
2012
9
Symptomatic Recovery in Miller Fisher Syndrome Parallels Vestibular-Perceptual and not Vestibular-Ocular Reflex Function. (21350734)
2011
10
Motor and sensory conduction failure in overlap of Guillain-BarrAc and Miller Fisher syndrome: two simultaneous cases. (21316711)
2011
11
Bickerstaff's encephalitis and Miller Fisher syndrome associated with voltage-gated potassium channel and novel anti-neuronal antibodies. (20236177)
2010
12
Electrophysiological evidence of cerebellar fiber system involvement in the Miller Fisher syndrome. (19863971)
2010
13
Miller-Fisher syndrome in a patient with rheumatoid arthritis treated with adalimumab. (18818868)
2009
14
Bilateral enhancement of the cranial nerves III-XII in severe Miller-Fisher syndrome. (19672080)
2009
15
Miller-Fisher syndrome associated with chronic lymphocytic leukemia. (18688150)
2008
16
Eyelid nystagmus in Miller Fisher syndrome. (19029160)
2008
17
Positive "ice-on-eyes" test in Miller Fisher syndrome. (18502954)
2008
18
Unilateral external ophthalmoplegia in Miller Fisher syndrome: case report. (17439660)
2007
19
Headache associated with miller fisher syndrome. (17927654)
2007
20
Miller Fisher syndrome: a case with pattern of pure sensory polyneuropathy concomitant with anti-GQ1B antibody. (17479657)
2007
21
Miller Fisher syndrome and Escherichia coli infection: is it a novel association? (17608309)
2007
22
A case of Miller Fisher syndrome with anti GQ1b in Thailand. (17375649)
2007
23
Intravenous immunoglobulin therapy for Miller Fisher syndrome. (17404197)
2007
24
Anti-GQ1b-negative Miller-Fisher syndrome with lower cranial nerve involvement from parasinusoidal aspergilloma. (16081159)
2006
25
Ganglioside complexes as targets for antibodies in Miller Fisher syndrome. (16754692)
2006
26
Spontaneous recovery in a case of Miller-Fisher syndrome presenting as polyneuritis cranialis. (16862205)
2006
27
Anti-ganglioside complex antibodies in Miller Fisher syndrome. (16614007)
2006
28
Topical diclofenac for the treatment of eyeache in Miller-Fisher syndrome. (16411102)
2006
29
Recurrent Miller-Fisher syndrome. (14975425)
2004
30
Miller Fisher variant of Guillain-BarrAc syndrome associated with lactic acidosis and stavudine therapy. (12746793)
2003
31
Clinical, electrophysiological, and serological overlap between Miller Fisher syndrome and acute sensory ataxic neuropathy. (11982496)
2002
32
Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome. (11148238)
2001
33
Transcranial magnetic stimulation studies in the Miller Fisher syndrome: evidence of corticospinal tract abnormality. (11459894)
2001
34
Miller Fisher syndrome: toward a more comprehensive understanding. (11780304)
2001
35
The miller fisher syndrome: an infranuclear cause of diffuse ophthalmoplegia. (21149044)
2001
36
Miller Fisher syndrome: immunofluorescence and immunoelectron microscopic localization of IgG at the mouse neuromuscular junction. (11307623)
2001
37
Amplified fragment length polymorphism analysis of Campylobacter jejuni strains isolated from chickens and from patients with gastroenteritis or Guillain-BarrAc or Miller Fisher syndrome. (10966409)
2000
38
Miller Fisher syndrome: an uncommon acute neuropathy. (10802419)
2000
39
The immunopathogenesis of Miller Fisher syndrome. (10695710)
1999
40
Neurosyphilis mimicking Miller-Fisher syndrome: a case report and MRI findings. (9674818)
1998
41
Neuromuscular blockade by immunoglobulin G from patients with Miller Fisher syndrome. (9668311)
1998
42
Anti-GQ1b IgG antibody activities related to the severity of Miller Fisher syndrome. (9785590)
1998
43
Cross-reactive antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in patients with Guillain-BarrAc or Miller Fisher syndrome. (9041356)
1997
44
Somatosensory evoked blink response: findings in patients with Miller Fisher syndrome and in normal subjects. (7823078)
1995
45
Lupus erythematosus and Miller-Fisher syndrome. (8042933)
1994
46
Abnormal evoked potentials in Miller-Fisher syndrome: further evidence of combined peripheral and central demyelination. (8164009)
1994
47
Miller Fisher syndrome is associated with serum antibodies to GQ1b ganglioside. (8437011)
1993
48
Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-BarrAc syndrome: clinical and immunohistochemical studies. (8413947)
1993
49
The localization of the lesion in patients with acute ophthalmoplegia, ataxia and areflexia (Miller Fisher syndrome). A serial multimodal neurophysiological study. (2835120)
1988
50
Demyelinating optic neuropathy with Miller-Fisher syndrome. The case for overlap syndromes with central and peripheral demyelination. (3612209)
1987

Genetic Variations for Miller Fisher Syndrome

Expression for genes affiliated with Miller Fisher Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for genes affiliated with Miller Fisher Syndrome

Compounds for genes affiliated with Miller Fisher Syndrome

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45Novoseek, 29IUPHAR
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Compounds related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il-12459.0SRF, TNF
2neopterin459.0SRF, TNF
3okt3458.9SRF, TNF
4peptidoglycan45 299.7SRF, TNF

GO Terms for genes affiliated with Miller Fisher Syndrome

Sources:
16Gene Ontology
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Biological processes related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:0096159.3TNF, HMGA2
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9SRF, TNF
3negative regulation of transcription from RNA polymerase II promoterGO:0001228.9GSC, HMGA2, TNF
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.2HMGA2, TNF, SRF

Molecular functions related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.1SRF, HMGA2

Products for genes affiliated with Miller Fisher Syndrome

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Sources for Miller Fisher Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet