MCID: MLL002
MIFTS: 45

Miller Fisher Syndrome malady

Neuronal diseases category

Summaries for Miller Fisher Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Miller-fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of guillain-barré syndrome. it is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. like guillain-barré syndrome, symptoms may be preceded by a viral illness. additional symptoms include generalized muscle weakness and respiratory failure. the majority of individuals with miller-fisher syndrome have a unique antibody that characterizes the disorder. treatment includes intravenous immunoglobulin (ivig) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. last updated: 10/21/2011

MalaCards: Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to guillain-barre syndrome and ophthalmoplegia. An important gene associated with Miller Fisher Syndrome is GSC (goosecoid homeobox). The compounds il-12 and neopterin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung, and related mouse phenotypes are limbs/digits/tail and behavior/neurological.

Disease Ontology:8 A guillain-barre syndrome that manifests as a descending paralysis. it usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS:43 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:63 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Aliases & Classifications for Miller Fisher Syndrome

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 48Orphanet, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
cranial variant of guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

miller fisher syndrome 8 43 10 44 60
cranial variant of guillain-barré syndrome 42 48
miller-fisher syndrome 42 48
cranial variant of gbs 42 48
miller-fisher variant of guillain-barre syndrome 8
fisher's syndrome 8
fisher syndrome 48


External Ids:

Disease Ontology8 DOID:12889
MeSH34 D019846
MESH via Orphanet35 D019846
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet57 1767005
UMLS via Orphanet61 C0393799

Related Diseases for Miller Fisher Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to miller fisher syndrome

Clinical Features for Miller Fisher Syndrome

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Drugs & Therapeutics for Miller Fisher Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Miller Fisher Syndrome

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Anatomical Context for Miller Fisher Syndrome

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32MalaCards
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MalaCards organs/tissues related to Miller Fisher Syndrome:

32
Eye, Brain, Lung, Testes, B cells, Dorsal root ganglion

Animal Models for Miller Fisher Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Miller Fisher Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6GSC, HMGA2, TNF
2MP:00053868.1GSC, SRF, HMGA2, TNF

Publications for Miller Fisher Syndrome

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50PubMed
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Articles related to Miller Fisher Syndrome:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Internal ophthalmoplegia as the initial symptom of Miller-Fisher syndrome. (24075583)
2013
2
Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oculomotor weakness in Guillain-BarrAc syndrome and Miller Fisher syndrome. (23173866)
2013
3
A young lady with thalamic stroke mimicking acute Miller Fisher syndrome. (23022907)
2012
4
Recurrent Miller Fisher syndrome with vestibular involvement. (21934313)
2011
5
Atypical Miller Fisher syndrome associated with glutamate receptor antibodies. (22707623)
2011
6
Miller fisher syndrome presents as an acute voice change to hypernasal speech. (20213780)
2010
7
The H reflex as a diagnostic tool for Miller Fisher syndrome in pediatric patients. (20071180)
2010
8
Detection of MCP-1 and IL-8 in the serum and cerebrospinal fluid of a child with Miller Fisher syndrome. (19846311)
2009
9
A combined presentation of Graves' disease and Miller-Fisher syndrome. (18514733)
2008
10
Miller Fisher syndrome associated with Burkitt's lymphoma. (16643330)
2006
11
An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome. (15596779)
2004
12
Miller Fisher syndrome associated with Pasteurella multocida infection. (15548510)
2004
13
MR imaging findings of spinal posterior column involvement in a case of Miller Fisher syndrome. (15090361)
2004
14
Association of cardiomyopathy caused by autonomic nervous system impairment with the Miller Fisher syndrome. (12700327)
2003
15
Bickerstaff's brainstem encephalitis, Miller Fisher syndrome and Guillain-Barre syndrome overlap with negative anti-GQ1b antibodies. (12603297)
2003
16
Corticobulbar dysfunction in the Miller Fisher syndrome. (12860506)
2003
17
Miller Fisher syndrome. (14601502)
2003
18
Childhood Miller Fisher syndrome: case report and review of the literature. (12422918)
2002
19
Miller-Fisher syndrome and Hodgkin's disease. (12185180)
2002
20
Miller Fisher syndrome and plasmapheresis. (12460409)
2002
21
Benign intracranial hypertension: atypical presentation of Miller Fisher syndrome? (11955933)
2002
22
Miller Fisher syndrome in adult onset Still's disease: case report and review of the literature of other neurological manifestations. (11886973)
2002
23
Guillain-BarrAc syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits. (11254608)
2001
24
Miller Fisher syndrome: MRI findings. (11723258)
2001
25
Clinical features and prognosis of Miller Fisher syndrome. (11320188)
2001
26
Ataxic Guillain-BarrAc syndrome with anti-GQ1b antibody: relation to Miller Fisher syndrome. (10802797)
2000
27
Miller Fisher syndrome: axonal, demyelinating or both? (11155543)
2000
28
Miller fisher syndrome: a hospital-based retrospective study. (10965158)
2000
29
Acute onset of a bilateral areflexical mydriasis in Miller-Fisher syndrome: a rare neuro-ophthalmologic disease. (10770512)
2000
30
Cerebral infarction complicating intravenous immunoglobulin therapy in a patient with Miller Fisher syndrome. (10811710)
2000
31
Use of photic feedback as an adjunct treatment in a case of Miller Fisher syndrome. (10769908)
2000
32
Miller Fisher syndrome associated with bulbar paralysis and elevation of antibodies against gangliosides. (10618891)
1999
33
Development of facial palsy during immunoadsorption plasmapheresis in Miller Fisher syndrome: a clinical report of two cases. (9527160)
1998
34
Lipo-oligosaccharides of Campylobacter jejuni serotype O:10. Structures of core oligosaccharide regions from a bacterial isolate from a patient with the Miller-Fisher syndrome and from the serotype reference strain. (9581276)
1997
35
Molecular mimicry between gangliosides and lipopolysaccharides of Campylobacter jejuni isolated from patients with Guillain-BarrAc syndrome and Miller Fisher syndrome. (9396700)
1997
36
Atypical Miller Fisher syndrome with GQ1b antibodies. (18638884)
1996
37
Cranial nerve enhancement on three-dimensional MRI in Miller Fisher syndrome. (8960757)
1996
38
Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3. (8757818)
1996
39
HLA and anti-GQ1b IgG antibody in Miller Fisher syndrome and Guillain-BarrAc syndrome. (7560017)
1995
40
Life-threatening hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with the miller fisher syndrome. (15251587)
1995
41
Miller-Fisher syndrome with rapid recovery. (7910293)
1994
42
Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome. (8120137)
1994
43
Pediatric Miller Fisher syndrome requiring intubation: a case report. (8344052)
1993
44
Miller Fisher syndrome: etiological significance of serial blink reflexes and MRI study. (1623849)
1992
45
Miller Fisher syndrome in systemic lupus erythematosus. (2273495)
1990
46
Miller-Fisher syndrome and pontine abnormalities on MRI: a case report. (1963636)
1990
47
A case of Miller Fisher syndrome. (3217336)
1988
48
Neuropathological findings in Miller Fisher syndrome. (6736980)
1984
49
The Miller-Fisher syndrome--a case report. (6529746)
1984
50
Successful plasmapheresis in the Miller-Fisher syndrome. (6786483)
1981

Genetic Variations for Miller Fisher Syndrome

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Expression for genes affiliated with Miller Fisher Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Miller Fisher Syndrome

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Pathways for genes affiliated with Miller Fisher Syndrome

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Compounds for genes affiliated with Miller Fisher Syndrome

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44Novoseek, 28IUPHAR
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Compounds related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il-12449.0SRF, TNF
2neopterin449.0SRF, TNF
3okt3448.9SRF, TNF
4peptidoglycan44 289.7SRF, TNF

GO Terms for genes affiliated with Miller Fisher Syndrome

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16Gene Ontology
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Biological processes related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:0096159.3HMGA2, TNF
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9SRF, TNF
3negative regulation of transcription from RNA polymerase II promoterGO:0001228.9GSC, HMGA2, TNF
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TNF, HMGA2, SRF

Molecular functions related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.1SRF, HMGA2

Products for genes affiliated with Miller Fisher Syndrome

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Sources for Miller Fisher Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet