MCID: MLL002
MIFTS: 45

Miller Fisher Syndrome malady

Neuronal diseases category

Summaries for Miller Fisher Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Miller-fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of guillain-barré syndrome. it is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. like guillain-barré syndrome, symptoms may be preceded by a viral illness. additional symptoms include generalized muscle weakness and respiratory failure. the majority of individuals with miller-fisher syndrome have a unique antibody that characterizes the disorder. treatment includes intravenous immunoglobulin (ivig) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. last updated: 10/21/2011

MalaCards: Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to guillain-barre syndrome and ophthalmoplegia. An important gene associated with Miller Fisher Syndrome is GSC (goosecoid homeobox). The compounds il-12 and neopterin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are limbs/digits/tail and behavior/neurological.

Disease Ontology:8 A guillain-barre syndrome that manifests as a descending paralysis. it usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS:43 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:63 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Aliases & Classifications for Miller Fisher Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
cranial variant of guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

miller fisher syndrome 8 43 10 44 60
cranial variant of guillain-barré syndrome 42 48
miller-fisher syndrome 42 48
cranial variant of gbs 42 48
miller-fisher variant of guillain-barre syndrome 8
fisher's syndrome 8
fisher syndrome 48


External Ids:

Disease Ontology8 DOID:12889
MeSH34 D019846
MESH via Orphanet35 D019846
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet57 1767005
UMLS via Orphanet61 C0393799

Related Diseases for Miller Fisher Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to miller fisher syndrome

Clinical Features for Miller Fisher Syndrome

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Drugs & Therapeutics for Miller Fisher Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Miller Fisher Syndrome

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Anatomical Context for Miller Fisher Syndrome

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32MalaCards
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MalaCards organs/tissues related to Miller Fisher Syndrome:

32
Eye, Brain, Testes, Lung, B cells, Dorsal root ganglion

Animal Models for Miller Fisher Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Miller Fisher Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6GSC, HMGA2, TNF
2MP:00053868.1GSC, SRF, HMGA2, TNF

Publications for Miller Fisher Syndrome

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50PubMed
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Articles related to Miller Fisher Syndrome:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Postvaccination Miller Fisher syndrome after combined pertussis, diphtheria and tetanus toxoid vaccine. (23219950)
2013
2
Miller Fisher syndrome with positivity of anti-GAD antibodies. (24103627)
2013
3
Miller Fisher syndrome mimicking ocular myasthenia gravis. (23190719)
2012
4
Miller Fisher syndrome associated with influenza A infection. (22989838)
2012
5
Pallidal hyperintensities--a coincidental finding of clinical relevance in Miller Fisher syndrome. (21749567)
2011
6
Bickerstaff's encephalitis and Miller Fisher syndrome associated with voltage-gated potassium channel and novel anti-neuronal antibodies. (20236177)
2010
7
Anti-GQ1b-negative Miller Fisher syndrome presented with one-sided horizontal gaze palsy. (20718193)
2010
8
Miller Fisher syndrome in a 66-year-old female after flu and pneumovax vaccinations. (18457810)
2008
9
Ocular presentation of pediatric Miller-Fisher syndrome. (18705624)
2008
10
Miller Fisher syndrome--an uncommon clinical presentation. (19263690)
2008
11
Recurrent miller fisher syndrome with abnormal terminal axon dysfunction: a case report. (18416284)
2007
12
Unusual manifestations in Miller-Fisher syndrome. (17691564)
2007
13
Clinical and immunological spectrum of the Miller Fisher syndrome. (17657801)
2007
14
Presynaptic neuromuscular transmission defect in the Miller Fisher syndrome. (16401873)
2006
15
A case of recurrent Miller Fisher syndrome mimicking botulism. (17205228)
2006
16
Acute angle closure in Miller Fisher syndrome. (16052258)
2006
17
Recent developments in Miller Fisher syndrome and related disorders. (16155441)
2005
18
Posterior reversible encephalopathy complicating intravenous immunoglobulins in a patient with miller-fisher syndrome. (16118497)
2005
19
Miller-Fisher syndrome mimicking intracranial hypertension following head trauma. (15830202)
2005
20
Miller Fisher syndrome possibly related to mycoplasma pneumoniae infection: report of one case. (15493737)
2004
21
Recurrent Miller Fisher syndrome. (15645989)
2004
22
Miller Fisher variant of Guillain-BarrAc syndrome associated with lactic acidosis and stavudine therapy. (12746793)
2003
23
Optic neuritis in anti-GQ1b positive recurrent Miller Fisher syndrome. (12928295)
2003
24
Clinical, electrophysiological, and serological overlap between Miller Fisher syndrome and acute sensory ataxic neuropathy. (11982496)
2002
25
Plasmapheresis and Miller Fisher syndrome: analysis of 50 consecutive cases. (11971070)
2002
26
Motor conduction studies in Miller Fisher syndrome with severe tetraparesis. (11870714)
2002
27
A child with Miller Fisher syndrome. (12174009)
2002
28
Complex gangliosides as autoantibody targets at the neuromuscular junction in Miller Fisher syndrome: a current perspective. (12374204)
2002
29
Involvement of the central nervous system in Miller Fisher syndrome: a case report. (12140109)
2002
30
Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome. (11148238)
2001
31
Miller Fisher syndrome in an elderly man. (11443034)
2001
32
Visual impairment in anti-GQ1b positive Miller Fisher syndrome. (11328199)
2001
33
Double agents and breakdown of integrity at the neuromuscular junction in Miller-Fisher syndrome. (11335689)
2001
34
Pain in Miller Fisher syndrome. (11081818)
2000
35
The immunopathogenesis of Miller Fisher syndrome. (10695710)
1999
36
Special sensory ataxia in Miller Fisher syndrome detected by postural body sway analysis. (10211482)
1999
37
Acute isolated ophthalmoplegia as a variant of Miller-Fisher syndrome. (9655138)
1998
38
Humoral immune response against Campylobacter jejuni lipopolysaccharides in Guillain-BarrAc and Miller Fisher syndrome. (9357448)
1997
39
Serum antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in Miller Fisher syndrome. (9317004)
1997
40
Miller Fisher syndrome in infancy. (8906374)
1996
41
Miller Fisher syndrome and anti-GQ1b antibodies. (7779653)
1995
42
Brainstem encephalitis and the Miller Fisher syndrome. (8382270)
1993
43
The use of intravenous immunoglobulin in Miller Fisher syndrome. (8214351)
1993
44
Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome. (1514781)
1992
45
Miller Fisher syndrome: an electrophysiologic case study. (3168912)
1988
46
Miller-Fisher syndrome (Guillain-BarrAc syndrome with ophthalmoplegia) during treatment with gold salts in a patient with rheumatoid arthritis. (3925959)
1985
47
Brainstem encephalitis or the Miller Fisher syndrome--a variant of acute idiopathic polyneuropathy. Case reports. (6648744)
1983
48
Successful plasmapheresis in the Miller-Fisher syndrome. (6786587)
1981
49
Peripheral nerve conduction in Miller Fisher syndrome. (925702)
1977
50
Miller-Fisher syndrome in a 22-month-old child. (5504080)
1970

Genetic Variations for Miller Fisher Syndrome

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Expression for genes affiliated with Miller Fisher Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Miller Fisher Syndrome

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Pathways for genes affiliated with Miller Fisher Syndrome

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Compounds for genes affiliated with Miller Fisher Syndrome

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44Novoseek, 28IUPHAR
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Compounds related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il-12449.0SRF, TNF
2neopterin449.0SRF, TNF
3okt3448.9SRF, TNF
4peptidoglycan44 289.7SRF, TNF

GO Terms for genes affiliated with Miller Fisher Syndrome

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16Gene Ontology
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Biological processes related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:0096159.3TNF, HMGA2
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9SRF, TNF
3negative regulation of transcription from RNA polymerase II promoterGO:0001228.9GSC, HMGA2, TNF
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.2HMGA2, TNF, SRF

Molecular functions related to Miller Fisher Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.1SRF, HMGA2

Products for genes affiliated with Miller Fisher Syndrome

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Sources for Miller Fisher Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet