MCID: MLL002
MIFTS: 39

Miller Fisher Syndrome

Categories: Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Miller Fisher Syndrome

MalaCards integrated aliases for Miller Fisher Syndrome:

Name: Miller Fisher Syndrome 12 51 52 42 14 69
Cranial Variant of Guillain-Barré Syndrome 50 56
Miller-Fisher Syndrome 50 56
Cranial Variant of Gbs 50 56
Miller-Fisher Variant of Guillain-Barre Syndrome 12
Fisher's Syndrome 12
Fisher Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
miller-fisher syndrome
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12889
ICD10 33 G61.0
MeSH 42 D019846
NCIt 47 C116958
Orphanet 56 ORPHA98919
MESH via Orphanet 43 D019846
UMLS via Orphanet 70 C0393799
ICD10 via Orphanet 34 G61.0
UMLS 69 C0393799

Summaries for Miller Fisher Syndrome

NIH Rare Diseases : 50 miller-fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of guillain-barré syndrome. it is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. like guillain-barré syndrome, symptoms may be preceded by a viral illness. additional symptoms include generalized muscle weakness and respiratory failure. the majority of individuals with miller-fisher syndrome have a unique antibody that characterizes the disorder. treatment includes intravenous immunoglobulin (ivig) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care. last updated: 10/21/2011

MalaCards based summary : Miller Fisher Syndrome, also known as cranial variant of guillain-barré syndrome, is related to lymphoma and kozlowski warren fisher syndrome, and has symptoms including cerebellar ataxia and ophthalmoplegia. An important gene associated with Miller Fisher Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Immune response NFAT in immune response and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and lung.

Disease Ontology : 12 A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.

NINDS : 51 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Related Diseases for Miller Fisher Syndrome

Diseases related to Miller Fisher Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.6 CD40LG TNF
2 kozlowski warren fisher syndrome 11.8
3 guillain-barre syndrome 11.5
4 bickerstaff brainstem encephalitis 11.4
5 rickettsialpox 10.6 CD40LG TNF
6 lung disease 10.6 CD40LG TNF
7 uveitis 10.6 CD40LG TNF
8 central nervous system leiomyosarcoma 10.6 CD40LG TNF
9 ileocolitis 10.6 CD40LG TNF
10 dermatomycosis 10.6 CD40LG TNF
11 alkhurma hemorrhagic fever 10.6 CD40LG TNF
12 discitis 10.6 CD40LG TNF
13 tularemia 10.6 CD40LG TNF
14 hepadnavirus infection 10.6 CD40LG TNF
15 bladder diverticulum 10.6 CD40LG TNF
16 functional gastric disease 10.6 CD40LG TNF
17 cellular schwannoma 10.6 CD40LG TNF
18 pyridoxine deficiency 10.6 CD40LG TNF
19 cryptococcosis 10.6 CD40LG TNF
20 megaloblastic anemia 10.6 CD40LG TNF
21 dracunculiasis 10.6 CD40LG TNF
22 acute vascular insufficiency of intestine 10.6 CD40LG TNF
23 peripheral nervous system disease 10.5 CD40LG TNF
24 conduct disorder 10.5 CD40LG TNF
25 testicular infarct 10.5 CD40LG TNF
26 ceruminous carcinoma 10.5 CD40LG TNF
27 foodborne botulism 10.5 CD40LG TNF
28 bartonellosis 10.5 CD40LG TNF
29 cutaneous fibrous histiocytoma 10.5 CD40LG TNF
30 human monocytic ehrlichiosis 10.5 CD40LG TNF
31 glioblastoma multiforme 10.5 CD40LG TNF
32 ostertagiasis 10.5 CD40LG TNF
33 membranoproliferative glomerulonephritis 10.5 CD40LG TNF
34 early congenital syphilis 10.5 CD40LG TNF
35 plummer's disease 10.5 CD40LG TNF
36 endogenous depression 10.5 CD40LG TNF
37 residual stage corticosteroid-induced glaucoma 10.5 CD40LG TNF
38 crest syndrome 10.5 CD40LG TNF
39 nasopharyngitis 10.5 CD40LG TNF
40 tick-borne encephalitis 10.5 CD40LG TNF
41 disease of mental health 10.5 CD40LG TNF
42 extrahepatic bile duct adenocarcinoma 10.5 CD40LG TNF
43 iida kannari syndrome 10.5 CD40LG TNF
44 cannabis dependence 10.5 CD40LG MAG
45 uterine ligament papillary cystadenoma 10.5 CD40LG MAG
46 atrophy of prostate 10.5 CD40LG TNF
47 acute hemorrhagic encephalitis 10.5 CD40LG MAG
48 sublingual gland cancer 10.5 CD40LG TNF
49 arteriosclerosis 10.5 CD40LG MAG
50 esophagus melanoma 10.5 CD40LG TNF

Graphical network of the top 20 diseases related to Miller Fisher Syndrome:



Diseases related to Miller Fisher Syndrome

Symptoms & Phenotypes for Miller Fisher Syndrome

UMLS symptoms related to Miller Fisher Syndrome:


cerebellar ataxia, ophthalmoplegia

Drugs & Therapeutics for Miller Fisher Syndrome

Drugs for Miller Fisher Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
2 International Guillain-Barré Syndrome Outcome Study Recruiting NCT01582763

Search NIH Clinical Center for Miller Fisher Syndrome

Cochrane evidence based reviews: miller fisher syndrome

Genetic Tests for Miller Fisher Syndrome

Anatomical Context for Miller Fisher Syndrome

MalaCards organs/tissues related to Miller Fisher Syndrome:

39
Eye, Brain, Lung, Testes, Breast, B Cells, Dorsal Root Ganglion

Publications for Miller Fisher Syndrome

Articles related to Miller Fisher Syndrome:

(show top 50) (show all 275)
id Title Authors Year
1
A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence? ( 28090073 )
2017
2
MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. ( 28209311 )
2017
3
A Case of Miller Fisher Syndrome and Literature Review. ( 28367386 )
2017
4
Incomplete Miller-Fisher Syndrome with Advanced Stage Burkitt Lymphoma. ( 28601853 )
2017
5
Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. ( 28067631 )
2017
6
Multiple cranial nerve neuropathies, ataxia and, areflexia: Miller Fisher syndrome in a child and review. ( 28214063 )
2017
7
Unilateral Oculomotor Nerve Palsy Following Campylobacter Infection: A Mild Form of Miller Fisher Syndrome without Ataxia. ( 28943568 )
2017
8
Recurrent Guillain-BarrAc syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis. ( 27084218 )
2016
9
A case of miller fisher syndrome associated with preceding herpes zoster ophthalmicus. ( 27875624 )
2016
10
Late Presentation of Ataxia, Areflexia, and Electrophysiological Abnormalities as Part of Miller Fisher Syndrome: Case Report. ( 27928406 )
2016
11
An Overlapping Case of Miller Fisher Syndrome, Bickerstaff's Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome. ( 27974981 )
2016
12
Miller Fisher syndrome. ( 27737870 )
2016
13
Overlap of Myasthenia Gravis and Miller Fisher Syndrome. ( 27432103 )
2016
14
An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. ( 27597525 )
2016
15
Pediatric Miller Fisher Syndrome Complicating an Epstein-Barr Virus Infection. ( 27460528 )
2016
16
Posterior reversible encephalopathy syndrome following immunoglobulin therapy in a patient with Miller-Fisher syndrome. ( 26929465 )
2016
17
Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology? ( 27239355 )
2016
18
Takotsubo cardiomyopathy associated with Miller-Fisher syndrome. ( 28040387 )
2016
19
Miller Fisher syndrome presenting as palate paralysis. ( 27609285 )
2016
20
Miller Fisher Syndrome: A Case Report Highlighting Heterogeneity of Clinical Features and Focused Differential Diagnosis. ( 27437164 )
2016
21
An unusual presentation of Miller Fisher syndrome with optic neuropathy. ( 27554001 )
2016
22
Clinical Features of Miller-Fisher Syndrome in Pregnancy. ( 26697248 )
2015
23
False-Positive Serum Botulism Bioassay in Miller-Fisher Syndrome. ( 26301377 )
2015
24
Neuro-ophthalmological manifestations in three cases of Miller Fisher syndrome and a brief review of literature. ( 26588640 )
2015
25
A case of Miller Fisher syndrome during preoperative chemotherapy for breast cancer. ( 26629243 )
2015
26
Papilledema in an otherwise clinically typical case of Miller Fisher syndrome. ( 26455984 )
2015
27
Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis. ( 25890931 )
2015
28
Miller-Fisher Syndrome: Is the ataxia central or peripheral? ( 26331046 )
2015
29
Miller-Fisher syndrome associated with unilateral cerebral white matter lesions. ( 26377988 )
2015
30
Atypical Miller Fisher Syndrome with Anisocoria and Rapidly Fluctuating Pupillary Diameter. ( 26380131 )
2015
31
Novel Variant of Miller Fisher Syndrome Occurring With Tumor Necrosis Factor I+ Antagonist Therapy. ( 26551961 )
2015
32
Delayed facial palsy in Miller Fisher syndrome. ( 26277343 )
2015
33
Recurrent pediatric miller fisher syndrome. ( 25160556 )
2014
34
Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-BarrAc syndrome in the spectrum of nodo-paranodopathies. ( 24534627 )
2014
35
A Case of Neuromyelitis Optica Masquerading as Miller Fisher Syndrome. ( 25408664 )
2014
36
Total internal and external ophthalmoplegia as presenting symptoms of Miller Fisher syndrome. ( 25121494 )
2014
37
Cerebral infarction 3 weeks after intravenous immunoglobulin for Miller Fisher syndrome: a case report. ( 24661403 )
2014
38
Taste impairment in Miller Fisher syndrome. ( 25116259 )
2014
39
Posterior reversible encephalopathy syndrome and stroke after intravenous immunoglobulin treatment in Miller-Fisher syndrome/Bickerstaff brain stem encephalitis overlap syndrome. ( 25149206 )
2014
40
Miller Fisher syndrome with presynaptic neuromuscular transmission disorder. ( 25300589 )
2014
41
Acute Angle-Closure Glaucoma in a Patient With Miller Fisher Syndrome Without Pupillary Dysfunction. ( 25393040 )
2014
42
Miller Fisher syndrome related to Orientia tsutsugamushi infection. ( 25065842 )
2014
43
A pediatric case of Miller Fisher syndrome with central involvement. ( 23196382 )
2013
44
Internal ophthalmoplegia as the initial symptom of Miller-Fisher syndrome. ( 24075583 )
2013
45
Miller Fisher syndrome with positivity of anti-GAD antibodies. ( 24103627 )
2013
46
The effectiveness of immunomodulating treatment on Miller Fisher syndrome: a retrospective analysis of 65 Chinese patients. ( 23781970 )
2013
47
Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oculomotor weakness in Guillain-BarrAc syndrome and Miller Fisher syndrome. ( 23173866 )
2013
48
A case of atypical Miller Fisher syndrome with negative anti-GQ1b immunoglobulin G and importance of H reflex. ( 24192691 )
2013
49
Miller Fisher syndrome with positivity of anti-GAD antibodies. ( 24094904 )
2013
50
Limb motor nerve dysfunction in Miller Fisher syndrome. ( 23521640 )
2013

Variations for Miller Fisher Syndrome

Expression for Miller Fisher Syndrome

Search GEO for disease gene expression data for Miller Fisher Syndrome.

Pathways for Miller Fisher Syndrome

GO Terms for Miller Fisher Syndrome

Biological processes related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Miller Fisher Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 CD40LG TNF

Sources for Miller Fisher Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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