Mirror Movements 2

Categories: Genetic diseases

Aliases & Classifications for Mirror Movements 2

MalaCards integrated aliases for Mirror Movements 2:

Name: Mirror Movements 2 54 24 71 29 13 69
Mrmv2 71



incomplete penetrance (50%)
disorder usually remains stable over time
onset in infancy or early childhood

autosomal dominant


mirror movements 2:
Inheritance autosomal dominant inheritance
Onset and clinical course incomplete penetrance


External Ids:

OMIM 54 614508
MedGen 40 C3281089
MeSH 42 D020820
SNOMED-CT via HPO 65 263681008 229247004

Summaries for Mirror Movements 2

OMIM : 54
Mirror movements are involuntary movements of a side of the body that mirror intentional movements on the opposite side. Mild mirror movements are physiologic in young children and gradually disappear within the first decade of life, likely due to maturation of the motor network. Mirror movements that persist beyond age 10 years represent a rare disorder usually showing autosomal dominant inheritance with incomplete penetrance (summary by Depienne et al., 2012). For a discussion of genetic heterogeneity of mirror movements, see MRMV1 (157600). (614508)

MalaCards based summary : Mirror Movements 2, is also known as mrmv2, and has symptoms including bimanual synkinesia An important gene associated with Mirror Movements 2 is RAD51 (RAD51 Recombinase). The drugs Menthol and Mirabegron have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

UniProtKB/Swiss-Prot : 71 Mirror movements 2: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.

Related Diseases for Mirror Movements 2

Diseases in the Mirror Movements 2 family:

Mirror Movements 3

Symptoms & Phenotypes for Mirror Movements 2

Symptoms via clinical synopsis from OMIM:


Neurologic- Central Nervous System:
abnormal corticospinal tract decussation
difficulties in fine bimanual activities
writing fatigability
mirror movements, involuntary, usually of the upper limb and hand

Muscle Soft Tissue:
pain or cramping during sustained manual activity

Clinical features from OMIM:


Human phenotypes related to Mirror Movements 2:

id Description HPO Frequency HPO Source Accession
1 bimanual synkinesia 32 HP:0001335

Drugs & Therapeutics for Mirror Movements 2

Drugs for Mirror Movements 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
2 Mirabegron Approved Phase 1 223673-61-8
3 Adrenergic Agents Phase 1
4 Adrenergic Agonists Phase 1
5 Adrenergic beta-3 Receptor Agonists Phase 1
6 Adrenergic beta-Agonists Phase 1
7 Neurotransmitter Agents Phase 1
Epinephrine Approved, Vet_approved 51-43-4 5816
9 Racepinephrine Approved
Benzocaine Approved 1994-09-7, 94-09-7 2337
Pilocarpine Approved 54-71-7, 92-13-7 5910
12 Propoxycaine Approved 86-43-1
13 tannic acid Approved, Nutraceutical
14 Epinephryl borate
15 Anesthetics
16 Anesthetics, Local
17 Autonomic Agents
18 Central Nervous System Depressants
19 Cholinergic Agents
20 Peripheral Nervous System Agents
21 Proxymetacaine

Interventional clinical trials:

(show all 30)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Mirror Therapy in Stroke Patients With Unilateral Neglect - A Randomized Controlled Trial Completed NCT01735877 Phase 3
2 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
3 Mirror Therapy After Stroke: A Dosing Study Recruiting NCT02778087 Phase 2, Phase 3
4 Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction Unknown status NCT01010607 Phase 1, Phase 2
5 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
6 Robot Assisted Upper Limb Neuro-Rehabilitation Completed NCT00011583 Phase 2
7 Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta 3-Adrenergic Receptor Agonists Recruiting NCT03049462 Phase 1 Mirabegron
8 Robot- Versus Mirror-Assisted Rehabilitation in Stroke Patients Unknown status NCT01724164
9 Effects of RR and MT on Patient With Stroke Unknown status NCT01655446
10 Robot-Assisted Therapy in Stroke Patients Unknown status NCT00917605
11 Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain Unknown status NCT00639431
12 Role of the SMA During Unimanual and Bimanual Movements Preparation: the Mirror Movements Paradigm Completed NCT02073604
13 A Clinical Trial to Study the Effect of Imagined Progressive Movements in Patients With Paralysis of One Side of the Body. Completed NCT02232295
14 Mirroring a Movement Completed NCT00123448
15 Effects of Intensive Robot-assisted Therapy in Patients With Subacute Stroke Completed NCT01767480
16 Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System Completed NCT00872183
17 Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies Completed NCT02199158
18 Walking Adaptability Post-Spinal Cord Injury Completed NCT01851629
19 Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms Recruiting NCT02878746
20 Reaching Training Based on Robotic Hybrid Assistance for Stroke Patients ( RETRAINER-S2 ) Recruiting NCT03199833
21 Hybrid Approach to Mirror Therapy and Transcranial Direct Current Stimulation for Stroke Recovery Recruiting NCT02254616
22 PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy Recruiting NCT02131909
23 Early Independent Adaptive Arm and Hand Rehab Recruiting NCT02749500
24 Effect of Mirror Therapy Versus Bilateral Arm Training for Rehabilitation After Chronic Stroke Recruiting NCT02548234
25 Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure Recruiting NCT02613013 Pilocarpine;Proparacaine
26 Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS) Recruiting NCT02487966
27 Enhanced Reality for Hemiparetic Arm in the Stroke Patients Not yet recruiting NCT03270852
28 Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment Not yet recruiting NCT02838485
29 Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures Not yet recruiting NCT02957240
30 Efficacy of Unilateral Versus Bilateral Approach to Robot-Assisted Rehabilitation in Patients With Subacute Stroke Withdrawn NCT01939041

Search NIH Clinical Center for Mirror Movements 2

Genetic Tests for Mirror Movements 2

Genetic tests related to Mirror Movements 2:

id Genetic test Affiliating Genes
1 Mirror Movements 2 29 24 RAD51

Anatomical Context for Mirror Movements 2

MalaCards organs/tissues related to Mirror Movements 2:

Spinal Cord

Publications for Mirror Movements 2

Variations for Mirror Movements 2

ClinVar genetic disease variations for Mirror Movements 2:

id Gene Variation Type Significance SNP ID Assembly Location
1 RAD51 NM_002875.4(RAD51): c.760C> T (p.Arg254Ter) single nucleotide variant Pathogenic,risk factor rs199925463 GRCh37 Chromosome 15, 41021818: 41021818
2 RAD51 NM_002875.4(RAD51): c.855dupA (p.Pro286Thrfs) duplication Pathogenic rs724159986 GRCh38 Chromosome 15, 40729933: 40729933

Expression for Mirror Movements 2

Search GEO for disease gene expression data for Mirror Movements 2.

Pathways for Mirror Movements 2

GO Terms for Mirror Movements 2

Sources for Mirror Movements 2

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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