MCID: MSM014
MIFTS: 56

Mismatch Repair Cancer Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Blood diseases, Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Mismatch Repair Cancer Syndrome

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Aliases & Descriptions for Mismatch Repair Cancer Syndrome:

Name: Mismatch Repair Cancer Syndrome 49 11 45 67
Turcot Syndrome 45 22 47 67 24 65
Constitutional Mismatch Repair Deficiency Syndrome 51 67
Mismatch Repair Deficiency 45 67
Mmr Deficiency 45 67
Mmrcs 45 67
Malignant Tumors of the Central Nervous System Associated with Familial Polyposis of the Colon 45
Cns Tumors with Familial Polyposis of the Colon 45
Adenomatous Polyposis Coli with Cns Tumors 22
Brain Tumor-Polyposis Syndrome 1 67
 
Brain Tumor-Polyposis Syndrome 45
Malignant Childhood Neoplasm 65
Glioma-Polyposis Syndrome 45
Childhood Cancer Syndrome 67
Childhood Cancer 47
Cmmr-D Syndrome 51
Btp1 Syndrome 67
Cmmrds 67
Btps1 67

Characteristics:

Orphanet epidemiological data:

51
constitutional mismatch repair deficiency syndrome:
Inheritance: Autosomal recessive; Age of onset: Childhood

HPO:

61
mismatch repair cancer syndrome:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM49 276300
Orphanet51 252202
MedGen34 C0265325
MeSH36 D009386
UMLS65 C0265325, C0278704

Summaries for Mismatch Repair Cancer Syndrome

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OMIM:49 Constitutional mismatch repair deficiency is a rare childhood cancer predisposition syndrome with 4 main tumor types:... (276300) more...

MalaCards based summary: Mismatch Repair Cancer Syndrome, also known as turcot syndrome, is related to restless legs syndrome and breast cancer, and has symptoms including neoplasm of the colon, glioma and gastrointestinal hemorrhage. An important gene associated with Mismatch Repair Cancer Syndrome is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways are Deactivation of the beta-catenin transactivating complex and Regulation of Microtubule Cytoskeleton. Affiliated tissues include colon, brain and skin, and related mouse phenotypes are pigmentation and endocrine/exocrine gland.

NIH Rare Diseases:45 Turcot syndrome is a condition characterized by multiple adenomatous colon polyps, an increased risk of colorectal cancer, and an increased risk of brain cancer. it may be associated with familial adenomatous polyposis (fap) or lynch syndrome (also known as hereditary non-polyposis colorectal cancer or hnpcc). the molecular basis of most turcot syndrome is either a mutation in apc associated with fap or a mutation in one of the mismatch repair genes associated with lynch syndrome (mlh1 and pms2). the brain tumors in individuals with apc mutations are typically medulloblastoma, whereas those with mismatch repair mutations are usually glioblastoma multiforme. turcot syndrome typically follows an autosomal dominant inheritance pattern. last updated: 8/29/2012

UniProtKB/Swiss-Prot:67 Mismatch repair cancer syndrome: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.

Wikipedia:68 Mismatch repair cancer syndrome (MMRCS) is a cancer syndrome associated with biallelic DNA mismatch... more...

Related Diseases for Mismatch Repair Cancer Syndrome

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Diseases related to Mismatch Repair Cancer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1restless legs syndrome29.6APC, CTNNB1, MSH2, MSH6
2breast cancer28.8APC, CTNNB1, MLH1, MSH2, MSH6, PTEN
3colorectal cancer28.0APC, CTNNB1, MLH1, MSH2, MSH6, PMS1
4non-polyposis turcot syndrome12.3
5turcot syndrome with polyposis12.3
6adenomatous polyposis coli11.8
7mlh1-related turcot syndrome11.6
8msh2-related turcot syndrome11.6
9msh6-related turcot syndrome11.6
10pms2-related turcot syndrome11.6
11retinoblastoma11.5
12glioma susceptibility 110.6
13neurofibromatosis, type 110.6
14intracranial abscess10.3MLH1, MSH6
15chorioretinitis10.3MLH1, MSH2
16familial congenital fourth cranial nerve palsy10.3APC, MSH2
17post-surgical hypoinsulinemia10.2MSH2, PMS1
18transverse colon cancer10.2CTNNB1, MLH1
19beckwith-wiedemann syndrome10.2
20childhood leukemia10.2
21fibrous meningioma10.2APC, CTNNB1
22lacrimal passage granuloma10.2MSH2, MSH6
23iron metabolism disease10.2APC, CTNNB1
24colon mucinous adenocarcinoma10.1APC, CTNNB1
25retinitis10.1
26thyroiditis10.1
27skin squamous cell carcinoma10.1MLH1, MSH2
28allergic contact dermatitis10.1MLH1, MSH2, MSH6
29small non-cleaved cell lymphoma10.1MLH1, MSH2, MSH6
30leukemoid reaction10.1MLH1, MSH2, MSH6
31optic neuritis10.1
32papilledema10.1
33neuritis10.1
34food allergy10.1
35atypical mole syndrome10.1APC, MSH2, MSH6
36fibromatosis multiple non ossifying10.1APC, CTNNB1
37chondroblastoma10.1MLH1, MSH2, PMS1
38neuroblastoma10.0
39li-fraumeni syndrome10.0
40adrenal carcinoma10.0
41brain tumor, childhood10.0
42hyperinsulinism-hyperammonemia syndrome10.0APC, PTEN
43ovary neuroendocrine neoplasm10.0CTNNB1, PTEN
44choriocarcinoma10.0
45biliary tract neoplasm10.0APC, CTNNB1, MLH1
46ulnar neuropathy10.0APC, CTNNB1, MLH1
47adenomyoma of uterine corpus10.0CTNNB1, MLH1, MSH2
48hereditary renal cell carcinoma10.0MLH1, MSH2, PAX3
49organ system benign neoplasm10.0APC, CTNNB1, MLH1
50desmoid disease, hereditary10.0APC, CTNNB1

Graphical network of the top 20 diseases related to Mismatch Repair Cancer Syndrome:



Diseases related to mismatch repair cancer syndrome

Symptoms for Mismatch Repair Cancer Syndrome

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Symptoms by clinical synopsis from OMIM:

276300

Clinical features from OMIM:

276300

HPO human phenotypes related to Mismatch Repair Cancer Syndrome:

(show all 53)
id Description Frequency HPO Source Accession
1 neoplasm of the colon hallmark (90%) HP:0100273
2 glioma hallmark (90%) HP:0009733
3 gastrointestinal hemorrhage hallmark (90%) HP:0002239
4 abdominal pain hallmark (90%) HP:0002027
5 malabsorption hallmark (90%) HP:0002024
6 constipation hallmark (90%) HP:0002019
7 weight loss hallmark (90%) HP:0001824
8 neoplasm of the rectum typical (50%) HP:0100743
9 attention deficit hyperactivity disorder typical (50%) HP:0007018
10 increased intracranial pressure typical (50%) HP:0002516
11 migraine typical (50%) HP:0002076
12 nausea and vomiting typical (50%) HP:0002017
13 hypertonia typical (50%) HP:0001276
14 muscular hypotonia typical (50%) HP:0001252
15 seizures typical (50%) HP:0001250
16 intestinal polyposis occasional (7.5%) HP:0200008
17 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835
18 ovarian neoplasm occasional (7.5%) HP:0100615
19 amaurosis fugax occasional (7.5%) HP:0100576
20 sarcoma occasional (7.5%) HP:0100242
21 neoplasm of the thyroid gland occasional (7.5%) HP:0100031
22 urinary tract neoplasm occasional (7.5%) HP:0010786
23 uterine neoplasm occasional (7.5%) HP:0010784
24 neoplasm of the skeletal system occasional (7.5%) HP:0010622
25 agnosia occasional (7.5%) HP:0010524
26 neoplasm of the skin occasional (7.5%) HP:0008069
27 abnormal pyramidal signs occasional (7.5%) HP:0007256
28 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
29 paresthesia occasional (7.5%) HP:0003401
30 neuroblastoma occasional (7.5%) HP:0003006
31 neoplasm of the liver occasional (7.5%) HP:0002896
32 neoplasm of the pancreas occasional (7.5%) HP:0002894
33 developmental regression occasional (7.5%) HP:0002376
34 memory impairment occasional (7.5%) HP:0002354
35 neurological speech impairment occasional (7.5%) HP:0002167
36 flexion contracture occasional (7.5%) HP:0001371
37 gait disturbance occasional (7.5%) HP:0001288
38 visual field defect occasional (7.5%) HP:0001123
39 hallucinations occasional (7.5%) HP:0000738
40 visual impairment occasional (7.5%) HP:0000505
41 agenesis of corpus callosum rare (5%) HP:0001274
42 glioblastoma HP:0100843
43 neuroblastoma HP:0003006
44 ependymoma HP:0002888
45 medulloblastoma HP:0002885
46 rhabdomyosarcoma HP:0002859
47 basal cell carcinoma HP:0002671
48 lymphoma HP:0002665
49 leukemia HP:0001909
50 abnormality of the abdomen HP:0001438
51 hypermelanotic macule HP:0001034
52 axillary freckling HP:0000997
53 cafe-au-lait spot HP:0000957

Drugs & Therapeutics for Mismatch Repair Cancer Syndrome

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Drugs for Mismatch Repair Cancer Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Capecitabineapproved, investigationalPhase 31220154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
2
FluorouracilapprovedPhase 3168451-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
3
AspirinapprovedPhase 3102950-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
7 Select Adult Chewable Aspirin
7 Select Aspirin
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Adult Chewable Low Dose Aspirin
Adult Low Dose Aspirin
Adult Low Dose Aspirin Enteric Safety Coated
Adult Low Dose Enteric Coated Aspirin
Adult Low Strength Aspirin
Aloxiprimum
Asacard
Asagran
Asaphen
Asatard
Ascoden-30
Ascriptin Maximum Strength Buffered Aspirin
Ascriptin Regular Strength Buffered Aspirin
Aspalon
Aspec
Aspergum
Aspi-cor
Aspir Low
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin 81 Mg
Aspirin 81 Mg Low Dose
Aspirin Adult Low Dose
Aspirin Adult Low Strength
Aspirin Adult Low Strength Aspirin
Aspirin Adult low strength
Aspirin Chewable Low Dose
Aspirin Delayed Release
Aspirin EC
Aspirin EXTRA STRENGTH
Aspirin Ec
Aspirin Enteric
Aspirin Enteric Coated
Aspirin Enteric Coated Low Dose
Aspirin Enteric Safety Coated
Aspirin Enteric Safety-Coated
Aspirin Low Dose
Aspirin Low Dose Chewable
Aspirin Low Dose Enteric Coated
Aspirin Low Dose Safety Coated
Aspirin Low Strength
Aspirin Nsaid
Aspirin Regular Strength
Aspirin Regular Strength regular strength
Aspirin Regular strength
Aspirin Safety Coated
Aspirin Safety Coated Adult Low Dose
Aspirin Safety coated
Aspirin Thin coated
Aspirin [BAN:JAN]
Aspirin adult low dose
Aspirin adult low strength
Aspirin enteric safety coated
Aspirin low dose
Aspirin low dose chewable
Aspirin low dose enteric coated
Aspirin regular strength
Aspirina 03
Aspirine
Aspiring
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Advanced Aspirin Extra Strength
Bayer Advanced Aspirin Regular Strength
Bayer Aspirin 8 Hour
Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange
Bayer Aspirin Regimen Regular Strength
Bayer Buffered
Bayer Chewable - Aspirin Regimen Low Dose Aspirin Cherry Flavored
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Fast Release
Bayer Genuine Aspirin
Bayer Low Dose
Bayer Plus
Bayer Plus Extra Strength
Bayer Womens
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Buffered Aspirin
Bufferin
Bufferin LOW DOSE BUFFERED ASPIRIN
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Care One Aspirin
Cemirit
Chewable Adult Low Dose Aspirin
Chewable Aspirin
Chewable Low Dose Aspirin
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Critical Care Aspirin To Go
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dg Health Aspirin
Direct Safety Aspirin
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ec-81aspirin Enteric Coated
Ecolen
Ecotrin
Ecotrin Regular Strength
Empirin
Empirin with Codeine
Endosprin
Endydol
Enteric Aspirin
Enteric Coated Aspirin
Enteric Coated Aspirin Regular Strength
Enteric Coated Aspirin Regular strength
Enteric Coated Aspirin regular strength
Enteric Coated Asprin 81 Mg
Enteric Coated Low Dose Aspirin
 
Enteric Safety Coated Aspirin
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Equaline Aspirin
Equaline Aspirin adult low dose
Equate Aspirin
Equate Aspirin chewable
Extren
Fasprin
Flanax Aspirin Pain Reliever
Formucare Aspirin
Genuine Aspirin
Globentyl
Globoid
Good Neighbor Pharmacy Aspirin
Good Neighbor Pharmacy Aspirin Enteric Safety Coated
Good Neighbor Pharmacy Aspirin orange flavor chewable
Good Sense Aspirin
Good Sense Aspirin Enteric Safety Coated
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Handy Solutions Genuine Aspirin Bayer
Health Mart Aspirin
Health Mart Regular Strength Enteric Coated Aspirin
Health Sense Adult Chewable Low Strength Aspirin
Health Sense Aspirin 81
Health Sense Ecpirin
Healthy Accents Aspirin
Helicon
Henry Schein Aspirin
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kroger Value Aspirin
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Leader Aspirin
Leader Cardinal Health Aspirin
Leader Low Dose Aspirin
Levius
Lopac-A-5376
Lopac0_000038
Low Dose Adult Aspirin
Low Dose Aspirin
Low Dose Aspirin 81 Mg Safety Coated
Low Dose Aspirin Enteric Safety Coated
Low Dose Asprin
Low Dose Chewable Aspirin
Low Dose Miniprin Enteric Safety Coated
Low Dose Pain Relief Aspirin
Low Strength Chewable Aspirin
Low-dose Aspirin
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medi First Plus Aspirin
Medi-first Aspirin
Medique Aspirin
Medisyl
Micristin
Micro-coated Aspirin
Miniprin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
North Aspirin
Novasen
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Pain Relief Aspirin
Pain Relief Aspirin Low Dose
Persistin
Pharbest Aspirin 325mg
Pharbest Regular Strength Aspirin
Pharmacin
Pirseal
Plus Pharma NSAID 325 mg
Plus Pharma Nsaid Aspirin
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rapid Comfort Aspirin
Regular Strength Aspirin
Regular Strength Aspirin Ec
Regular Strength Buffered Aspirin
Regular Strength Enteric Aspirin
Regular Strength Enteric Coated Aspirin
Regular Strength Pain Relief
Regular Strength Tri-buffered Aspirin
Rexall Aspirin
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
Rugby Aspirin
Rx Act Aspirin
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Safety Coated Aspirin
Safety Coated Enteric Aspirin
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Smart Health Aspirin regular strength
Smart Sense Aspirin
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Solves - Aspirin Cherry
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
St. Joseph Chewable Aspirin
St. Joseph Safety Coated Aspirin
Sunmark Aspirin
Sunmark Aspirin Regular Strength
Sunmark Aspirin adult low strength
Sunmark Aspirin low dose
Supac
Tasprin
Temperal
Toldex
Topcare Aspirin
Tri-buffered Aspirin
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Uncoated Aspirin
Value Pharma Aspirin Pain Reliever
Value Pharmapain Reliever Extra Strength
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
Zee Aspirin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
4Antirheumatic AgentsPhase 3, Phase 18496
5Cyclooxygenase InhibitorsPhase 3, Phase 12225
6AntimetabolitesPhase 39454
7Anti-Inflammatory Agents, Non-SteroidalPhase 3, Phase 13549
8Peripheral Nervous System AgentsPhase 3, Phase 118510
9Antimetabolites, AntineoplasticPhase 35770
10Anti-Inflammatory AgentsPhase 3, Phase 18478
11AnalgesicsPhase 3, Phase 19358
12Analgesics, Non-NarcoticPhase 3, Phase 15184
13AntipyreticsPhase 31140
14Fibrinolytic AgentsPhase 31567
15Platelet Aggregation InhibitorsPhase 31935
16ColaNutraceuticalPhase 31768
17
CrizotinibapprovedPhase 292877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-Crizotinib
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
Crizotinib
Crizotinibum
 
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-02341066
PF-2341066
Xalkori
crizotinib
18
EpinephrineapprovedPhase 283451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
19
Sunitinibapproved, investigationalPhase 2486341031-54-7, 557795-19-45329102
Synonyms:
(2S)-2-hydroxybutanedioic acid
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
326914-13-0
341031-54-7
5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
557795-19-4
AC1NS62J
AC1O5CMQ
AKOS005145765
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
CHEBI:38940
CHEBI:550864
CHEMBL1567
CHEMBL535
CID5329102
CID6456015
D06402
D08552
DB01268
DB07417
EN002687
FT-0083555
FT-0083556
I01-1229
K00588a
KS-5022
LS-186078
LS-187023
LS-187648
MolPort-003-986-763
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
 
NSC736511
NSC750690
PDGF TK antagonist
PHA-290940AD
PNU-290940AD
S1042_Selleck
ST51053712
SU 011248
SU 11248
SU-010398
SU-011248 L-malate salt
SU-11248
SU-11248 L-malate salt
SU-11248J
SU-12662
SU010398
SU011248
SU011248 L-malate salt
SU11248
Su-011248
Sunitanib
Sunitinib
Sunitinib (INN)
Sunitinib (free base)
Sunitinib Malate
Sunitinib malate
Sunitinib malate (JAN/USAN)
Sunitinib malate [USAN]
Sunitinibum
Sutent
Sutent (TN)
Sutent, SU-11248
TL8002546
UNII-LVX8N1UT73
UNII-V99T50803M
sunitinib
sunitinibum
20
Dasatinibapproved, investigationalPhase 2268302962-49-83062316
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
AC1MI3ET
AC1Q2P0C
AmbotzLS-1203
Anh. dasatinib
Anhydrous dasatinib
BCB03_000715
BMS 354825
BMS dasatinib
BMS-354825
BMS-354825, Sprycel, BMS354825, Dasatinib
BMS354825
C488369
CHEBI:49375
CHEMBL1421
CID3062316
D03658
DB01254
Dasatinib
Dasatinib (USAN)
Dasatinib (anh.)
Dasatinib [USAN]
Dasatinib anhydrous
Dasatinib, BMS 354825
 
Dasatinibum
EC-000.2122
EN002710
FT-0084503
I14-1972
Kinome_3650
LS-186641
LS-187028
LS-187773
MolPort-003-846-143
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
NSC-732517
NSC732517
S1021_Selleck
SPRYCEL (TN)
Sprycel
Spyrcel
UNII-X78UG0A0RN
dasatinib
dasatinibum
nchembio.117-comp11
nchembio.162-comp4
nchembio.332-comp1
21
DabrafenibapprovedPhase 27044462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
22
Trastuzumabapproved, investigationalPhase 2726180288-69-19903
Synonyms:
180288-69-1
Anti HER2
Anti-erbB2 Monoclonal Antibody
D03257
HER2 Monoclonal Antibody
Herceptin
 
Herceptin (TN)
Ig gamma-1 chain C region
Trastuzumab
Trastuzumab (INN)
Trastuzumab (genetical recombination)
Trastuzumab (genetical recombination) (JAN)
trastuzumab
23
TrametinibapprovedPhase 2111871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
24
ado-trastuzumab emtansineapprovedPhase 2621018448-65-1
Synonyms:
Kadcyla
 
Trastuzumab-DM1
trastuzumab emtansine
trastuzumab-MCC-DM1
25Protein Kinase InhibitorsPhase 23162
26RacepinephrinePhase 2834
27
osimertinibPhase 23771496458
Synonyms:
 
Tagrisso
mereletinib
28Tubulin ModulatorsPhase 24279
29
s 1 (combination)Phase 2325
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
30AntibodiesPhase 24477
31Antimitotic AgentsPhase 24296
32Angiogenesis Modulating AgentsPhase 23611
33Angiogenesis InhibitorsPhase 23688
34MaytansinePhase 251
35Antineoplastic Agents, PhytogenicPhase 24294
36Epinephryl boratePhase 2834
37ImmunoglobulinsPhase 24477
38ImmunoconjugatesPhase 246
39tyrosineNutraceuticalPhase 2596
40
NaproxenapprovedPhase 124522204-53-11302, 156391
Synonyms:
(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-(S)-Naproxen
(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionsaeure
(+)-2-(Methoxy-2-naphthyl)-propionsaeure [German]
(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-Naproxen
(+)NAPROXEN
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
(S)-()-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-()-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
(S)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-Naproxen
2-(6-Methoxy-2-naphthyl)propionic acid
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)- (8CI)
22204-53-1
284785_ALDRICH
46482_FLUKA
46482_RIEDEL
65126_FLUKA
AC-1363
AC1L4G3X
AC1Q4ET9
AC1Q4F4H
AC1Q4F4I
ARONIS24306
Acusprain
Aleve
Anaprox
Anax
Anexopen
Apo-Napro-NA
Apo-Naproxen
Apronax
Artagen
Arthrisil
Artrixen
Artroxen
Atiflan
Axer
BIDD:GT0062
BRD-K59197931-001-02-9
BRD-K59197931-236-09-6
BSPBio_002067
Bipronyl
Bonyl
CAS-22204-53-1
CCRIS 5265
CG 3117
CHEBI:7476
CHEMBL154
CID156391
Calosen
Clinosyn
Congex
D-Naproxen
DB08298
DL Naproxen
DL-Naproxen
Danaprox
Daprox
Diocodal
DivK1c_000242
Duk
Dysmenalgit
Dysmenalgit N
EINECS 244-838-7
Ec-Naprosyn
Ec-naprosyn
Equiproxen
Equiproxen (Veterinary)
FT-0082415
Flanax Forte
Flexen
Flexipen
Floginax
Fuxen
Genoxen
HMS1920P13
HMS2089N21
HMS2091H12
HMS500M04
HSDB 3369
Headlon
IDI1_000242
InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
KBio1_000242
KBio2_001457
KBio2_004025
KBio2_006593
KBio3_001567
KBioGR_000597
KBioSS_001457
LS-124738
Laraflex
Lefaine
Leniartil
 
Lopac0_000792
M1021
Methoxypropiocin
MolPort-000-145-960
N8280_SIAL
NAPROXEN
NCGC00016759-01
NCGC00021127-01
NCGC00161591-01
NINDS_000242
NPS
Nafasol
Naixan
Nalyxan
Napflam
Napmel
Naposin
Napratec
Naprelan
Napren
Napren E
Naprius
Naprolag
Naprontag
Naprosin
Naprosyn
Naprosyn LLE
Naprosyn LLE Forte
Naprosyne
Naproxen
Naproxen Kit
Naproxen Sodium
Naproxen [USAN:BAN:INN:JAN]
Naproxen delayed release
Naproxen sodium
Naproxene
Naproxene [INN-French]
Naproxeno
Naproxeno [INN-Spanish]
Naproxenum
Naproxenum [INN-Latin]
Naproxi 250
Naproxi 500
Naproxène
Napxen
Narma
Narocin
Naxen
Naxen F
Naxopren
Naxyn
Naxyn 250
Naxyn 500
Noflam
Novonaprox
Nycopren
Opipramol
Patxen
Prafena
Prestwick0_000791
Prestwick1_000791
Prestwick2_000791
Prestwick_349
Prexan
Priaxen
Pronaxen
Proxen LE
Proxen LLE
RS 3540
RS-3540
Rahsen
Reuxen
Rheumaflex
Roxen
SPBio_000966
SPBio_002861
SPECTRUM1500425
SR-01000075977-3
STOCK1N-50633
Saritilron
Sinartrin
Sinton
Soproxen
Spectrum2_001043
Spectrum3_000514
Spectrum4_000069
Spectrum5_001327
Spectrum_000977
Sutolin
Sutony
TL8003659
Tohexen
Traumox
U-Ritis
UNII-57Y76R9ATQ
UPCMLD-DP001
UPCMLD-DP001:001
Velsay
Veradol
Vinsen
Xenar
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure [German]
d-2-(6-Methoxy-2-naphthyl)propionic acid
d-Naproxen

Interventional clinical trials:

idNameStatusNCT IDPhase
1Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and OverRecruitingNCT02355379Phase 3
2Aspirin as a Cancer Preventive in Carriers of a Germline Pathological Mismatch Repair Gene Defect, Lynch SyndromeNot yet recruitingNCT02497820Phase 3
3NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors or LymphomasSuspendedNCT02465060Phase 2
4Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch SyndromeRecruitingNCT02052908Phase 1
5Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment SelectionRecruitingNCT02750657
6Familial Cancer Registry and DNA BankRecruitingNCT02083224
7Adherence to Colon Cancer Screening (ACCS)RecruitingNCT02112747
8I-Scan For Colon Polyp Detection In HNPCCRecruitingNCT01823471
9Biomarkers in Samples From Patients With Endometrial CancerNot yet recruitingNCT01199250

Search NIH Clinical Center for Mismatch Repair Cancer Syndrome

Genetic Tests for Mismatch Repair Cancer Syndrome

About this section

Genetic tests related to Mismatch Repair Cancer Syndrome:

id Genetic test Affiliating Genes
1 Turcot Syndrome22 PMS2

Anatomical Context for Mismatch Repair Cancer Syndrome

About this section

MalaCards organs/tissues related to Mismatch Repair Cancer Syndrome:

33
Colon, Brain, Skin, Thyroid, Liver, Pancreas, Testes

Animal Models for Mismatch Repair Cancer Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Mismatch Repair Cancer Syndrome:

38 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9APC, CTNNB1, PAX3, PTEN
2MP:00053798.3APC, CTNNB1, MLH1, PAX3, PMS2, PTEN
3MP:00053708.1APC, CTNNB1, MYCN, PAX3, PTEN
4MP:00053718.0APC, CTNNB1, MYCN, PAX3, PTEN
5MP:00053678.0APC, CTNNB1, MYCN, PAX3, PTEN
6MP:00053897.9APC, CTNNB1, MLH1, MYCN, PMS2, PTEN
7MP:00053697.9APC, CTNNB1, MYCN, PAX3, PTEN
8MP:00107717.8APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
9MP:00053917.7APC, CTNNB1, MLH1, MYCN, PAX3, PTEN
10MP:00020067.1APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
11MP:00053977.1APC, CTNNB1, MSH2, MYCN, PAX3, PMS2
12MP:00053817.0APC, CTNNB1, MLH1, MSH2, MYCN, PAX3
13MP:00053846.6APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
14MP:00053766.5APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
15MP:00107686.5APC, CTNNB1, MLH1, MSH2, MSH6, MYCN

Publications for Mismatch Repair Cancer Syndrome

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Articles related to Mismatch Repair Cancer Syndrome:

idTitleAuthorsYear
1
Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetate. (9818855)
1998

Variations for Mismatch Repair Cancer Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Mismatch Repair Cancer Syndrome:

67
id Symbol AA change Variation ID SNP ID
1MLH1p.Met35AsnVAR_043388
2PMS2p.Ser46IleVAR_066838

Clinvar genetic disease variations for Mismatch Repair Cancer Syndrome:

5 (show all 30)
id Gene Variation Type Significance SNP ID Assembly Location
1MLH1NM_000249.3(MLH1): c.1852_1854delAAG (p.Lys618del)deletionPathogenicrs63751247GRCh37Chr 3, 37089130: 37089132
2MLH1NM_000249.3(MLH1): c.676C> T (p.Arg226Ter)single nucleotide variantPathogenicrs63751615GRCh37Chr 3, 37053589: 37053589
3MLH1NM_000249.3(MLH1): c.199G> T (p.Gly67Trp)single nucleotide variantPathogenicrs63750206GRCh37Chr 3, 37038192: 37038192
4MLH1MLH1, EX16DELdeletionPathogenic
5MLH1NM_000249.3(MLH1): c.1942C> T (p.Pro648Ser)single nucleotide variantPathogenicrs63750899GRCh37Chr 3, 37090053: 37090053
6MLH1MLH1, 2-BP DEL, 593AGdeletionPathogenic
7MLH1NM_000249.3(MLH1): c.104_105delTGinsAC (p.Met35Asn)indelPathogenicrs121912965GRCh37Chr 3, 37035142: 37035143
8MSH2MSH2, EX1-6 DELdeletionPathogenic
9MSH2NM_000251.2(MSH2): c.454delA (p.Met152Cysfs)deletionPathogenicrs63751449GRCh37Chr 2, 47637320: 47637320
10PMS2NM_000535.6(PMS2): c.2002A> G (p.Ile668Val)single nucleotide variantPathogenicrs869320619GRCh37Chr 7, 6026394: 6026394
11PMS2PMS2, EX11-EX14 DEL/18-BP INSindelPathogenic
12MLH1NM_000249.3(MLH1): c.218T> G (p.Leu73Arg)single nucleotide variantPathogenicrs397514684GRCh37Chr 3, 37042456: 37042456
13MSH6MSH6, TRP1024TERundetermined variantPathogenic
14MSH6MSH6, 3-BP DEL, NT3609deletionPathogenic
15MSH6NM_000179.2(MSH6): c.3633dupT (p.Val1212Cysfs)duplicationPathogenicrs587776706GRCh37Chr 2, 48032833: 48032833
16MSH6MSH6, 1-BP INS, 1596TinsertionPathogenic
17MSH6MSH6, 1-BP DEL, 3261CdeletionPathogenic
18MSH2NM_000251.2(MSH2): c.1662-1G> Asingle nucleotide variantPathogenicrs267607970GRCh37Chr 2, 47698103: 47698103
19PMS2NM_000535.5(PMS2): c.1306dupA (p.Ser436Lysfs)duplicationPathogenicrs63750106GRCh37Chr 7, 6027090: 6027090
20PMS2NM_000535.5(PMS2): c.1927C> T (p.Gln643Ter)single nucleotide variantPathogenicrs63751422GRCh37Chr 7, 6026469: 6026469
21PMS2NM_000535.5(PMS2): c.400C> T (p.Arg134Ter)single nucleotide variantPathogenicrs63750871GRCh37Chr 7, 6042221: 6042221
22PMS2NM_000535.5(PMS2): c.1221delG (p.Thr408Leufs)deletionPathogenicrs587776715GRCh37Chr 7, 6027175: 6027175
23PMS2PMS2, 4-BP DEL, 2361CTTCdeletionPathogenic
24PMS2NM_000535.5(PMS2): c.2404C> T (p.Arg802Ter)single nucleotide variantPathogenicrs63751466GRCh37Chr 7, 6017260: 6017260
25PMS2PMS2, 2-BP DEL, 2184TCdeletionPathogenic
26PMS2PMS2, LYS577FSstructural variantPathogenic
27PMS2NM_000535.5(PMS2): c.137G> T (p.Ser46Ile)single nucleotide variantLikely pathogenicrs121434629GRCh37Chr 7, 6045549: 6045549
28PMS2PMS2, 20-BP INS, NT1169insertionPathogenic
29PMS2PMS2, 1-BP DEL, 182AdeletionPathogenic
30PMS2NM_000535.5(PMS2): c.219T> A (p.Cys73Ter)single nucleotide variantPathogenicrs121434630GRCh37Chr 7, 6043634: 6043634

Cosmic variations for Mismatch Repair Cancer Syndrome:

7 (show top 50)    (show all 18748)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM28746IDH1central nervous system,brain,glioma,NS3
2COSM28746IDH1central nervous system,NS,glioma,glioblastoma multiforme3
3COSM28746IDH1central nervous system,NS,glioma,glioblastoma multiforme3
4COSM28746IDH1central nervous system,brain,glioma,glioblastoma multiforme3
5COSM28746IDH1central nervous system,brain,glioma,NS3
6COSM28746IDH1central nervous system,brain,glioma,NS3
7COSM28746IDH1central nervous system,brain,glioma,NS3
8COSM28746IDH1central nervous system,brain,glioma,NS3
9COSM28746IDH1central nervous system,brain,glioma,NS3
10COSM28746IDH1central nervous system,brain,glioma,NS3
11COSM28746IDH1central nervous system,brain,glioma,NS3
12COSM28746IDH1central nervous system,brain,glioma,NS3
13COSM28746IDH1central nervous system,brain,other,neoplasm3
14COSM28746IDH1central nervous system,brain,glioma,NS3
15COSM28746IDH1central nervous system,brain,glioma,NS3
16COSM28746IDH1central nervous system,brain,glioma,NS3
17COSM28746IDH1central nervous system,brain,glioma,NS3
18COSM28746IDH1central nervous system,brain,glioma,NS3
19COSM28746IDH1central nervous system,brain,glioma,NS3
20COSM28746IDH1central nervous system,brain,glioma,NS3
21COSM28746IDH1central nervous system,brain,glioma,NS3
22COSM28746IDH1central nervous system,brain,glioma,NS3
23COSM28746IDH1central nervous system,brain,glioma,NS3
24COSM28746IDH1central nervous system,brain,other,neoplasm3
25COSM28746IDH1central nervous system,brain,other,neoplasm3
26COSM28746IDH1central nervous system,brain,glioma,NS3
27COSM28746IDH1central nervous system,brain,glioma,NS3
28COSM28746IDH1central nervous system,brain,glioma,NS3
29COSM28746IDH1central nervous system,brain,glioma,NS3
30COSM28746IDH1central nervous system,brain,glioma,NS3
31COSM28746IDH1central nervous system,brain,glioma,NS3
32COSM28746IDH1central nervous system,brain,glioma,NS3
33COSM28746IDH1central nervous system,brain,glioma,NS3
34COSM28746IDH1central nervous system,brain,glioma,NS3
35COSM28746IDH1central nervous system,brain,glioma,NS3
36COSM28746IDH1central nervous system,brain,glioma,NS3
37COSM28746IDH1central nervous system,brain,glioma,NS3
38COSM28746IDH1central nervous system,brain,glioma,NS3
39COSM28746IDH1central nervous system,brain,glioma,NS3
40COSM28746IDH1central nervous system,brain,other,neoplasm3
41COSM28746IDH1central nervous system,brain,glioma,NS3
42COSM28746IDH1central nervous system,brain,glioma,NS3
43COSM28746IDH1central nervous system,brain,glioma,NS3
44COSM28746IDH1central nervous system,brain,glioma,NS3
45COSM28746IDH1central nervous system,brain,glioma,NS3
46COSM28746IDH1central nervous system,brain,glioma,NS3
47COSM28746IDH1central nervous system,brain,glioma,NS3
48COSM28746IDH1central nervous system,brain,glioma,NS3
49COSM28746IDH1central nervous system,brain,glioma,NS3
50COSM28746IDH1central nervous system,brain,glioma,NS3

Expression for genes affiliated with Mismatch Repair Cancer Syndrome

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Search GEO for disease gene expression data for Mismatch Repair Cancer Syndrome.

Pathways for genes affiliated with Mismatch Repair Cancer Syndrome

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Pathways related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.5APC, CTNNB1
29.4APC, PTEN
39.4MLH1, MSH2, MSH6
4
Show member pathways
9.2MLH1, MSH2, MSH6
59.1MLH1, MSH2, MSH6, PMS2
6
Show member pathways
9.1MSH2, MSH6, PTEN
78.9APC, CTNNB1, PTEN
88.9APC, CTNNB1, PTEN
9
Show member pathways
8.9APC, CTNNB1, PTEN
10
Show member pathways
8.9MLH1, MSH2, PMS2, PTEN
11
Show member pathways
8.7MLH1, MSH2, MSH6, PMS1, PMS2
128.6CTNNB1, MSH2, MSH6, PTEN
138.5APC, CTNNB1, MLH1, MSH2, MSH6
148.4APC, MLH1, MSH2, PMS2, PTEN
157.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN
16
Show member pathways
7.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN

GO Terms for genes affiliated with Mismatch Repair Cancer Syndrome

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Cellular components related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chiasmaGO:000571210.1MLH1, PMS1
2cell cortexGO:00059389.5APC, CTNNB1

Biological processes related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.4MLH1, MSH2
2somatic recombination of immunoglobulin gene segmentsGO:001644710.4MLH1, MSH2
3negative regulation of DNA recombinationGO:004591010.3MSH2, MSH6
4regulation of cell differentiationGO:00455959.9APC, CTNNB1
5cell fate specificationGO:00017089.9APC, CTNNB1
6beta-catenin destruction complex disassemblyGO:19048869.8APC, CTNNB1
7embryonic digit morphogenesisGO:00427339.5CTNNB1, MYCN
8DNA repairGO:00062819.4MLH1, MSH2, MSH6
9cellular response to DNA damage stimulusGO:00069749.4APC, MLH1, MSH2
10response to drugGO:00424938.6APC, CTNNB1, PTEN

Molecular functions related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:003213710.5MSH2, MSH6
2single thymine insertion bindingGO:003214310.5MSH2, MSH6
3ADP bindingGO:004353110.4MSH2, MSH6
4double-stranded DNA bindingGO:000369010.1MSH2, MSH6
5protein C-terminus bindingGO:000802210.1CTNNB1, MSH2
6single-stranded DNA bindingGO:00036979.2MLH1, MSH2, PMS1, PMS2
7DNA bindingGO:00036779.1MSH2, MSH6, PMS1, PMS2
8protein bindingGO:00055157.8CTNNB1, MLH1, MSH2, PAX3, PMS2, PTEN

Sources for Mismatch Repair Cancer Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet