MCID: MSM014
MIFTS: 60

Mismatch Repair Cancer Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Blood diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Mismatch Repair Cancer Syndrome

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Aliases & Descriptions for Mismatch Repair Cancer Syndrome:

Name: Mismatch Repair Cancer Syndrome 50 46 68 12
Turcot Syndrome 46 23 68 25 48 66
Constitutional Mismatch Repair Deficiency Syndrome 52 68
Mismatch Repair Deficiency 46 68
Mmr Deficiency 46 68
Mmrcs 46 68
Malignant Tumors of the Central Nervous System Associated with Familial Polyposis of the Colon 46
Cns Tumors with Familial Polyposis of the Colon 46
Adenomatous Polyposis Coli with Cns Tumors 23
 
Brain Tumor-Polyposis Syndrome 1 68
Brain Tumor-Polyposis Syndrome 46
Glioma-Polyposis Syndrome 46
Childhood Cancer Syndrome 68
Childhood Cancer 48
Cmmr-D Syndrome 52
Btp1 Syndrome 68
Cmmrds 68
Btps1 68

Characteristics:

Orphanet epidemiological data:

52
constitutional mismatch repair deficiency syndrome:
Inheritance: Autosomal recessive; Age of onset: Childhood

HPO:

62
mismatch repair cancer syndrome:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM50 276300
Orphanet52 ORPHA252202
MedGen35 C0265325
MeSH37 D009386

Summaries for Mismatch Repair Cancer Syndrome

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OMIM:50 Constitutional mismatch repair deficiency is a rare childhood cancer predisposition syndrome with 4 main tumor types:... (276300) more...

MalaCards based summary: Mismatch Repair Cancer Syndrome, also known as turcot syndrome, is related to colorectal cancer and non-polyposis turcot syndrome, and has symptoms including weight loss, constipation and malabsorption. An important gene associated with Mismatch Repair Cancer Syndrome is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways are Busulfan Pathway, Pharmacodynamics and Doxorubicin Pathway, Pharmacokinetics. Affiliated tissues include colon, brain and skin, and related mouse phenotypes are pigmentation and liver/biliary system.

NIH Rare Diseases:46 Turcot syndrome is a condition characterized by multiple adenomatous colon polyps, an increased risk of colorectal cancer, and an increased risk of brain cancer. it may be associated with familial adenomatous polyposis (fap) or lynch syndrome (also known as hereditary non-polyposis colorectal cancer or hnpcc). the molecular basis of most turcot syndrome is either a mutation in apc associated with fap or a mutation in one of the mismatch repair genes associated with lynch syndrome (mlh1 and pms2). the brain tumors in individuals with apc mutations are typically medulloblastoma, whereas those with mismatch repair mutations are usually glioblastoma multiforme. turcot syndrome typically follows an autosomal dominant inheritance pattern. last updated: 8/29/2012

UniProtKB/Swiss-Prot:68 Mismatch repair cancer syndrome: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.

Wikipedia:69 Mismatch repair cancer syndrome (MMRCS) is a cancer syndrome associated with biallelic DNA mismatch... more...

Related Diseases for Mismatch Repair Cancer Syndrome

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Diseases related to Mismatch Repair Cancer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer27.6APC, CTNNB1, MLH1, MSH2, MSH6, PMS1
2non-polyposis turcot syndrome11.9
3adenomatous polyposis coli11.4
4retinoblastoma11.3
5mlh1-related turcot syndrome11.3
6msh2-related turcot syndrome11.3
7msh6-related turcot syndrome11.3
8pms2-related turcot syndrome11.3
9angioimmunoblastic lymphadenopathy with dysproteinemia10.5MLH1, MSH2
10pityriasis rosea10.5MLH1, MSH2
11sleeping sickness10.5MLH1, MSH6
12ampulla of vater squamous cell carcinoma10.4APC, MLH1
13childhood leukemia10.4
14acute perichondritis of pinna10.3MSH2, PMS1
15cecum lymphoma10.3MSH2, PMS1
16serous surface papilloma10.3CTNNB1, MLH1
17ehlers-danlos syndrome, type viic10.3APC, CTNNB1
18lynch syndrome10.2
19neuroblastoma10.2
20spleen angiosarcoma10.2MLH1, MSH2, MSH6
21solitary bone cyst10.2MLH1, MSH2, MSH6
22optic papillitis10.2MLH1, MSH2, MSH6
23glioma susceptibility 110.2
24neurofibromatosis, type 110.2
25myelophthisic anemia10.2APC, CTNNB1
26colver steer godman syndrome10.2APC, MLH1, MSH2
27acquired amegakaryocytic thrombocytopenia10.1APC, MSH2, MSH6
28fibrosing mediastinitis10.1APC, CTNNB1
29gastrointestinal neuroendocrine tumor10.1CTNNB1, MLH1
30leukemia10.1
31cervical adenomyoma10.1CTNNB1, MLH1, MSH2
32hyperaldosteronism10.0MLH1, MSH2, PAX3
33periapical granuloma10.0CTNNB1, MLH1, MSH2
34congenital hypomyelination neuropathy10.0CTNNB1, MLH1, MSH2
35endometrial cancer10.0
36neurofibromatosis10.0
37large intestine adenocarcinoma10.0MLH1, MSH2, MSH6, PMS2
38neuropathy, distal hereditary motor, type viib10.0MLH1, MSH2, MSH6, PMS2
39neurofibromatosis-noonan syndrome9.9MLH1, MSH2, MSH6, PMS2
40glomerulosclerosis, focal segmental, 79.9APC, PTEN
41in situ carcinoma9.9MLH1, MSH2, MSH6, PMS2
42desmoplastic infantile astrocytoma9.9APC, CTNNB1
43l-cell glucagon-like peptide producing tumor9.9MSH2, MYCN
44clear cell acanthoma9.9MLH1, MYCN
45thyrotoxic periodic paralysis 29.9CTNNB1, PTEN
46visual cortex disease9.8MLH1, PMS1, PTEN
47food allergy9.8MLH1, MSH2, MSH6, PMS1
48nodular degeneration of cornea9.7CTNNB1, MLH1, PTEN
49tempi syndrome9.7MYCN, PTEN
50prostate embryonal rhabdomyosarcoma9.7MSH2, MSH6, PAX3, PMS2

Graphical network of the top 20 diseases related to Mismatch Repair Cancer Syndrome:



Diseases related to mismatch repair cancer syndrome

Symptoms for Mismatch Repair Cancer Syndrome

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Symptoms by clinical synopsis from OMIM:

276300

Clinical features from OMIM:

276300

HPO human phenotypes related to Mismatch Repair Cancer Syndrome:

(show all 53)
id Description Frequency HPO Source Accession
1 weight loss hallmark (90%) HP:0001824
2 constipation hallmark (90%) HP:0002019
3 malabsorption hallmark (90%) HP:0002024
4 abdominal pain hallmark (90%) HP:0002027
5 gastrointestinal hemorrhage hallmark (90%) HP:0002239
6 glioma hallmark (90%) HP:0009733
7 neoplasm of the colon hallmark (90%) HP:0100273
8 seizures typical (50%) HP:0001250
9 muscular hypotonia typical (50%) HP:0001252
10 hypertonia typical (50%) HP:0001276
11 nausea and vomiting typical (50%) HP:0002017
12 migraine typical (50%) HP:0002076
13 increased intracranial pressure typical (50%) HP:0002516
14 attention deficit hyperactivity disorder typical (50%) HP:0007018
15 neoplasm of the rectum typical (50%) HP:0100743
16 visual impairment occasional (7.5%) HP:0000505
17 hallucinations occasional (7.5%) HP:0000738
18 visual field defect occasional (7.5%) HP:0001123
19 gait disturbance occasional (7.5%) HP:0001288
20 flexion contracture occasional (7.5%) HP:0001371
21 neurological speech impairment occasional (7.5%) HP:0002167
22 memory impairment occasional (7.5%) HP:0002354
23 developmental regression occasional (7.5%) HP:0002376
24 neoplasm of the pancreas occasional (7.5%) HP:0002894
25 neoplasm of the liver occasional (7.5%) HP:0002896
26 neuroblastoma occasional (7.5%) HP:0003006
27 paresthesia occasional (7.5%) HP:0003401
28 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
29 abnormal pyramidal signs occasional (7.5%) HP:0007256
30 neoplasm of the skin occasional (7.5%) HP:0008069
31 agnosia occasional (7.5%) HP:0010524
32 neoplasm of the skeletal system occasional (7.5%) HP:0010622
33 uterine neoplasm occasional (7.5%) HP:0010784
34 urinary tract neoplasm occasional (7.5%) HP:0010786
35 neoplasm of the thyroid gland occasional (7.5%) HP:0100031
36 sarcoma occasional (7.5%) HP:0100242
37 amaurosis fugax occasional (7.5%) HP:0100576
38 ovarian neoplasm occasional (7.5%) HP:0100615
39 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835
40 intestinal polyposis occasional (7.5%) HP:0200008
41 agenesis of corpus callosum rare (5%) HP:0001274
42 cafe-au-lait spot HP:0000957
43 axillary freckling HP:0000997
44 hypermelanotic macule HP:0001034
45 abnormality of the abdomen HP:0001438
46 leukemia HP:0001909
47 lymphoma HP:0002665
48 basal cell carcinoma HP:0002671
49 rhabdomyosarcoma HP:0002859
50 medulloblastoma HP:0002885
51 ependymoma HP:0002888
52 neuroblastoma HP:0003006
53 glioblastoma HP:0100843

Drugs & Therapeutics for Mismatch Repair Cancer Syndrome

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Drugs for Mismatch Repair Cancer Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FluorouracilPhase 3172851-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
2
CapecitabinePhase 31257154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
3
OxaliplatinPhase 3136661825-94-35310940, 9887054, 43805, 6857599, 9887054
Synonyms:
CHEMBL1201055
CID9887054
D01790
DACPLAT
Diaminocyclohexane Oxalatoplatinum
Eloxatin
Eloxatin (TN)
Elplat
Foloxatine
L-OHP
Oxalatoplatin
 
Oxalatoplatinum
Oxaliplatin (JAN/USAN/INN)
Oxaliplatin [Usan:Inn:Ban]
Oxaliplatino [Spanish]
Oxaliplatinum [Latin]
Oxaloplatine [French]
Oxaloplatino [Spanish]
Transplatin
oxaliplatin
oxaliplatine
oxaliplatino
oxaliplatinum
4
leucovorinPhase 3104758-05-9143, 54575
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
5
LevoleucovorinPhase 369668538-85-2
Synonyms:
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-5-formyltetrahydrofolic acid
(6S)-Folinic acid
(6S)-Leucovorin
 
(S)-Leucovorin
Citrovorum factor
L-Folinic acid
Levofolene
Levofolinic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
6
AspirinPhase 3107450-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
 
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
7
Folic AcidNutraceuticalPhase 3, Phase 1, Phase 2414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
8FolateNutraceuticalPhase 3, Phase 1, Phase 24143
9COLANutraceuticalPhase 31824
10
TrametinibPhase 2115871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
11
trastuzumabPhase 2751180288-69-19903
Synonyms:
180288-69-1
Anti HER2
Anti-erbB2 Monoclonal Antibody
D03257
HER2 Monoclonal Antibody
Herceptin
 
Herceptin (TN)
Ig gamma-1 chain C region
Trastuzumab
Trastuzumab (INN)
Trastuzumab (genetical recombination)
Trastuzumab (genetical recombination) (JAN)
trastuzumab
12
SunitinibPhase 2493341031-54-7, 557795-19-45329102
Synonyms:
(2S)-2-hydroxybutanedioic acid
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
326914-13-0
341031-54-7
5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
557795-19-4
AC1NS62J
AC1O5CMQ
AKOS005145765
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
CHEBI:38940
CHEBI:550864
CHEMBL1567
CHEMBL535
CID5329102
CID6456015
D06402
D08552
DB01268
DB07417
EN002687
FT-0083555
FT-0083556
I01-1229
K00588a
KS-5022
LS-186078
LS-187023
LS-187648
MolPort-003-986-763
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
 
NSC736511
NSC750690
PDGF TK antagonist
PHA-290940AD
PNU-290940AD
S1042_Selleck
ST51053712
SU 011248
SU 11248
SU-010398
SU-011248 L-malate salt
SU-11248
SU-11248 L-malate salt
SU-11248J
SU-12662
SU010398
SU011248
SU011248 L-malate salt
SU11248
Su-011248
Sunitanib
Sunitinib
Sunitinib (INN)
Sunitinib (free base)
Sunitinib malate
Sunitinib malate (JAN/USAN)
Sunitinib malate [USAN]
Sunitinibum
Sutent
Sutent (TN)
Sutent, SU-11248
TL8002546
UNII-LVX8N1UT73
UNII-V99T50803M
sunitinib
sunitinibum
13
ThioguaninePhase 1, Phase 281154-42-72723601
Synonyms:
154-42-7
2 Amino 6 Purinethiol
2-Amino 6MP
2-Amino 6mp
2-Amino-1,7-dihydro-6H-purin-6-thion
2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]
2-Amino-1,7-dihydro-6H-purine-6-thione
2-Amino-6-MP
2-Amino-6-mercaptopurine
2-Amino-6-merkaptopurin
2-Amino-6-merkaptopurin [Czech]
2-Amino-6-purinethiol
2-Amino-9H-purine-6-thiol
2-Aminopurin-6-thiol
2-Aminopurin-6-thiol [Czech]
2-Aminopurine-6(1H)-thione
2-Aminopurine-6-thiol
2-Thioguanine
2-amino-1,9-Dihydropurine-6-thione
2-amino-1H-purine-6(7H)-thione
2-amino-3,7-dihydropurine-6-thione
2-aminopurine-6-thiol
5580-03-0
6 Thioguanine
6-Mercapto-2-aminopurine
6-Mercaptoguanine
6-TG
6-Thioguanine
6-Thioguanine (6-TG)
6-Thioguanine, Thioguanine
A4660_SIGMA
A4882_SIGMA
AC-11125
AC1MC379
AI3-26078
AKOS003389499
BSPBio_001994
BW 5071
C07648
C5H7N5S
CCRIS 8997
CHEBI:136864
CHEMBL727
CID2723601
D013866
D08603
DB00352
DX4
DivK1c_000428
EINECS 205-827-2
FT-0083572
Glaxo Wellcome Brand of Thioguanine
Glaxo Wellcome Brand of Tioguanine
GlaxoSmithKline Brand of Thioguanine
GlaxoSmithKline Brand of Tioguanine
Guanine, thio- (VAN)
HMS1921E09
HMS2092M11
HMS501F10
HSDB 2504
I14-1541
IDI1_000428
KBio1_000428
KBio2_000715
KBio2_002476
KBio2_003283
KBio2_005044
 
KBio2_005851
KBio2_007612
KBio3_001494
KBio3_002954
KBioGR_001452
KBioGR_002476
KBioSS_000715
KBioSS_002483
LS-888
LT00455187
Lanvis
Lanvis (TN)
MLS001333131
MLS001333132
MolPort-000-929-106
MolPort-001-813-204
MolPort-003-984-174
NCGC00094792-01
NCGC00094792-02
NCGC00094792-03
NCI60_041643
NCIOpen2_004153
NINDS_000428
NSC 752
NSC-752
NSC752
S1774_Selleck
SBB067147
SMP2_000326
SMR000857244
SPBio_000849
SPECTRUM1500573
ST50298831
Spectrum2_000695
Spectrum3_000577
Spectrum4_000926
Spectrum5_001455
Spectrum_000235
T0212
TG
THG
Tabloid
ThG
Thioguanin GSK
Thioguanin-GSK
ThioguaninGSK
Thioguanine
Thioguanine Hemihydrate
Thioguanine Monosodium Salt
Thioguanine Tabloid
Thioguanine [USAN:BAN]
Tioguanin
Tioguanina
Tioguanina Wellcome
Tioguanina [INN-Spanish]
Tioguanine
Tioguanine (INN)
Tioguanine GlaxoSmithKline Brand
Tioguaninum
Tioguaninum [INN-Latin]
UNII-FTK8U1GZNX
UNII-WIX31ZPX66
WLN: T56 BNM FYM INJ FUS HZ
Wellcome Brand of Thioguanine
Wellcome U3B
ZINC18085533
cMAP_000061
purine antimetabolite: antimetabolite: inhibits nucleic acid replication
thioguanine
14
s 1 (combination)Phase 2343
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
15
MethotrexatePhase 1, Phase 214961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
16
DasatinibPhase 2276302962-49-83062316
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
AC1MI3ET
AC1Q2P0C
AmbotzLS-1203
Anhydrous dasatinib
BCB03_000715
BMS 354825
BMS dasatinib
BMS-354825
BMS-354825, Sprycel, BMS354825, Dasatinib
BMS354825
C488369
CHEBI:49375
CHEMBL1421
CID3062316
D03658
DB01254
Dasatinib
Dasatinib (USAN)
Dasatinib (anh.)
Dasatinib [USAN]
Dasatinib anhydrous
Dasatinib, BMS 354825
Dasatinibum
EC-000.2122
 
EN002710
FT-0084503
I14-1972
Kinome_3650
LS-186641
LS-187028
LS-187773
MolPort-003-846-143
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
NSC-732517
NSC732517
S1021_Selleck
SPRYCEL (TN)
Sprycel
Spyrcel
UNII-X78UG0A0RN
anh. dasatinib
dasatinib
dasatinib (anhydrous)
dasatinibum
nchembio.117-comp11
nchembio.162-comp4
nchembio.332-comp1
17
DabrafenibPhase 27544462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
18
CrizotinibPhase 297877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-Crizotinib
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
Crizotinib
Crizotinibum
 
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-02341066
PF-2341066
Xalkori
crizotinib
19
PalbociclibPhase 2107571190-30-211431660, 5005498
Synonyms:
2euf
571190-30-2
6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
AC1NS8RV
CHEMBL189963
CID5330286
 
EC-000.2350
Kinome_3823
Kinome_3824
LQQ
PD 0332991
PD 332991, PD 0332991, PD0332991
PD-0332991
PD-332991
PD0332991
Palbociclib
S1116_Selleck
20
EpinephrinePhase 288651-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
21
osimertinibPhase 2451421373-65-071496458
Synonyms:
Mereletinib
 
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Tagrisso
mereletinib
22
nivolumabPhase 2254946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
23tyrosineNutraceuticalPhase 2633
24
NaproxenPhase 124822204-53-11302, 156391
Synonyms:
(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-(S)-Naproxen
(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionsaeure
(+)-2-(Methoxy-2-naphthyl)-propionsaeure [German]
(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-Naproxen
(+)NAPROXEN
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
(S)-()-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-()-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
(S)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-Naproxen
2-(6-Methoxy-2-naphthyl)propionic acid
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)- (8CI)
22204-53-1
284785_ALDRICH
46482_FLUKA
46482_RIEDEL
65126_FLUKA
AC-1363
AC1L4G3X
AC1Q4ET9
AC1Q4F4H
AC1Q4F4I
ARONIS24306
Acusprain
Aleve
Anaprox
Anax
Anexopen
Apo-Napro-NA
Apo-Naproxen
Apronax
Artagen
Arthrisil
Artrixen
Artroxen
Atiflan
Axer
BIDD:GT0062
BRD-K59197931-001-02-9
BRD-K59197931-236-09-6
BSPBio_002067
Bipronyl
Bonyl
CAS-22204-53-1
CCRIS 5265
CG 3117
CHEBI:7476
CHEMBL154
CID156391
Calosen
Clinosyn
Congex
D-Naproxen
DB08298
DL Naproxen
DL-Naproxen
Danaprox
Daprox
Diocodal
DivK1c_000242
Duk
Dysmenalgit
Dysmenalgit N
EINECS 244-838-7
Ec-Naprosyn
Equiproxen
Equiproxen (Veterinary)
FT-0082415
Flanax Forte
Flexen
Flexipen
Floginax
Fuxen
Genoxen
HMS1920P13
HMS2089N21
HMS2091H12
HMS500M04
HSDB 3369
Headlon
IDI1_000242
InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
KBio1_000242
KBio2_001457
KBio2_004025
KBio2_006593
KBio3_001567
KBioGR_000597
KBioSS_001457
LS-124738
Laraflex
 
Lefaine
Leniartil
Lopac0_000792
M1021
Methoxypropiocin
MolPort-000-145-960
N8280_SIAL
NAPROXEN
NCGC00016759-01
NCGC00021127-01
NCGC00161591-01
NINDS_000242
NPS
Nafasol
Naixan
Nalyxan
Napflam
Napmel
Naposin
Napratec
Naprelan
Napren
Napren E
Naprius
Naprolag
Naprontag
Naprosin
Naprosyn LLE
Naprosyn LLE Forte
Naprosyne
Naproxen
Naproxen Sodium
Naproxen [USAN:BAN:INN:JAN]
Naproxene
Naproxene [INN-French]
Naproxeno
Naproxeno [INN-Spanish]
Naproxenum
Naproxenum [INN-Latin]
Naproxi 250
Naproxi 500
Naproxène
Napxen
Narma
Narocin
Naxen
Naxen F
Naxopren
Naxyn
Naxyn 250
Naxyn 500
Noflam
Novonaprox
Nycopren
Opipramol
Patxen
Prafena
Prestwick0_000791
Prestwick1_000791
Prestwick2_000791
Prestwick_349
Prexan
Priaxen
Pronaxen
Proxen LE
Proxen LLE
RS 3540
RS-3540
Rahsen
Reuxen
Rheumaflex
Roxen
SPBio_000966
SPBio_002861
SPECTRUM1500425
SR-01000075977-3
STOCK1N-50633
Saritilron
Sinartrin
Sinton
Soproxen
Spectrum2_001043
Spectrum3_000514
Spectrum4_000069
Spectrum5_001327
Spectrum_000977
Sutolin
Sutony
TL8003659
Tohexen
Traumox
U-Ritis
UNII-57Y76R9ATQ
UPCMLD-DP001
UPCMLD-DP001:001
Velsay
Veradol
Vinsen
Xenar
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure [German]
d-2-(6-Methoxy-2-naphthyl)propionic acid
d-Naproxen

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and OverRecruitingNCT02355379Phase 3
2Finding the Best Dose of Aspirin to Prevent Lynch Syndrome CancersNot yet recruitingNCT02497820Phase 3
3Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair or Microsatellite InstabilityNot yet recruitingNCT02912559Phase 3
4Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch SyndromeNot yet recruitingNCT02813824Phase 3
5NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors or LymphomasRecruitingNCT02465060Phase 2
6Thiopurine Enhanced ALL Maintenance TherapyRecruitingNCT02912676Phase 1, Phase 2
7Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch SyndromeRecruitingNCT02052908Phase 1
8Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment SelectionRecruitingNCT02750657
9Familial Cancer Registry and DNA BankRecruitingNCT02083224
10Adherence to Colon Cancer Screening (ACCS)RecruitingNCT02112747
11I-Scan For Colon Polyp Detection In HNPCCRecruitingNCT01823471
12Biomarkers in Samples From Patients With Endometrial CancerNot yet recruitingNCT01199250

Search NIH Clinical Center for Mismatch Repair Cancer Syndrome

Genetic Tests for Mismatch Repair Cancer Syndrome

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Genetic tests related to Mismatch Repair Cancer Syndrome:

id Genetic test Affiliating Genes
1 Turcot Syndrome25 23 PMS2

Anatomical Context for Mismatch Repair Cancer Syndrome

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MalaCards organs/tissues related to Mismatch Repair Cancer Syndrome:

34
Colon, Brain, Skin, Testes, Pancreas, Liver, Thyroid

Animal Models for Mismatch Repair Cancer Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Mismatch Repair Cancer Syndrome:

39 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0APC, CTNNB1, PAX3, PTEN
2MP:00053708.1APC, CTNNB1, MYCN, PAX3, PTEN
3MP:00053698.0APC, CTNNB1, MYCN, PAX3, PTEN
4MP:00053798.0APC, CTNNB1, MLH1, PAX3, PMS2, PTEN
5MP:00053897.9APC, CTNNB1, MLH1, MYCN, PMS2, PTEN
6MP:00107717.9APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
7MP:00053677.8APC, CTNNB1, MYCN, PAX3, PTEN
8MP:00053717.7APC, CTNNB1, MYCN, PAX3, PTEN
9MP:00053917.5APC, CTNNB1, MLH1, MYCN, PAX3, PTEN
10MP:00053977.3APC, CTNNB1, MSH2, MYCN, PAX3, PMS2
11MP:00020067.0APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
12MP:00053817.0APC, CTNNB1, MLH1, MSH2, MYCN, PAX3
13MP:00053846.7APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
14MP:00107686.5APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
15MP:00053766.4APC, CTNNB1, MLH1, MSH2, MSH6, MYCN

Publications for Mismatch Repair Cancer Syndrome

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Articles related to Mismatch Repair Cancer Syndrome:

idTitleAuthorsYear
1
Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome. (23483711)
2013

Variations for Mismatch Repair Cancer Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Mismatch Repair Cancer Syndrome:

68
id Symbol AA change Variation ID SNP ID
1MLH1p.Met35AsnVAR_043388
2PMS2p.Ser46IleVAR_066838rs121434629

Clinvar genetic disease variations for Mismatch Repair Cancer Syndrome:

5 (show all 30)
id Gene Variation Type Significance SNP ID Assembly Location
1MLH1NM_000249.3(MLH1): c.1852_1854delAAG (p.Lys618del)deletionPathogenicrs63751247GRCh37Chr 3, 37089130: 37089132
2MLH1NM_000249.3(MLH1): c.676C> T (p.Arg226Ter)single nucleotide variantPathogenicrs63751615GRCh37Chr 3, 37053589: 37053589
3MLH1NM_000249.3(MLH1): c.199G> T (p.Gly67Trp)single nucleotide variantPathogenicrs63750206GRCh37Chr 3, 37038192: 37038192
4MLH1MLH1, EX16DELdeletionPathogenic
5MLH1NM_000249.3(MLH1): c.1942C> T (p.Pro648Ser)single nucleotide variantPathogenicrs63750899GRCh37Chr 3, 37090053: 37090053
6MLH1MLH1, 2-BP DEL, 593AGdeletionPathogenic
7MLH1NM_000249.3(MLH1): c.104_105delTGinsAC (p.Met35Asn)indelPathogenicrs121912965GRCh37Chr 3, 37035142: 37035143
8MSH2MSH2, EX1-6 DELdeletionPathogenic
9MSH2NM_000251.2(MSH2): c.454delA (p.Met152Cysfs)deletionPathogenicrs63751449GRCh37Chr 2, 47637320: 47637320
10PMS2NM_000535.6(PMS2): c.2002A> G (p.Ile668Val)single nucleotide variantPathogenicrs869320619GRCh37Chr 7, 6026394: 6026394
11PMS2PMS2, EX11-EX14 DEL/18-BP INSindelPathogenic
12MLH1NM_000249.3(MLH1): c.218T> G (p.Leu73Arg)single nucleotide variantLikely pathogenic, Pathogenicrs397514684GRCh37Chr 3, 37042456: 37042456
13MSH6MSH6, TRP1024TERundetermined variantPathogenic
14MSH6MSH6, 3-BP DEL, NT3609deletionPathogenic
15MSH6NM_000179.2(MSH6): c.3633dupT (p.Val1212Cysfs)duplicationPathogenicrs587776706GRCh37Chr 2, 48032833: 48032833
16MSH6MSH6, 1-BP INS, 1596TinsertionPathogenic
17MSH6MSH6, 1-BP DEL, 3261CdeletionPathogenic
18MSH2NM_000251.2(MSH2): c.1662-1G> Asingle nucleotide variantPathogenicrs267607970GRCh37Chr 2, 47698103: 47698103
19PMS2NM_000535.6(PMS2): c.1306dupA (p.Ser436Lysfs)duplicationPathogenicrs63750106GRCh37Chr 7, 6027090: 6027090
20PMS2NM_000535.6(PMS2): c.1927C> T (p.Gln643Ter)single nucleotide variantPathogenicrs63751422GRCh37Chr 7, 6026469: 6026469
21PMS2NM_000535.6(PMS2): c.400C> T (p.Arg134Ter)single nucleotide variantPathogenicrs63750871GRCh37Chr 7, 6042221: 6042221
22PMS2NM_000535.6(PMS2): c.1221delG (p.Thr408Leufs)deletionPathogenicrs587776715GRCh37Chr 7, 6027175: 6027175
23PMS2PMS2, 4-BP DEL, 2361CTTCdeletionPathogenic
24PMS2NM_000535.6(PMS2): c.2404C> T (p.Arg802Ter)single nucleotide variantPathogenicrs63751466GRCh37Chr 7, 6017260: 6017260
25PMS2PMS2, 2-BP DEL, 2184TCdeletionPathogenic
26PMS2PMS2, LYS577FSstructural variantPathogenic
27PMS2NM_000535.6(PMS2): c.137G> T (p.Ser46Ile)single nucleotide variantLikely pathogenicrs121434629GRCh37Chr 7, 6045549: 6045549
28PMS2PMS2, 20-BP INS, NT1169insertionPathogenic
29PMS2PMS2, 1-BP DEL, 182AdeletionPathogenic
30PMS2NM_000535.6(PMS2): c.219T> A (p.Cys73Ter)single nucleotide variantPathogenicrs121434630GRCh37Chr 7, 6043634: 6043634

Cosmic variations for Mismatch Repair Cancer Syndrome:

8 (show top 50)    (show all 1921)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM39700ABL2central nervous system,brain,glioma,glioblastoma multiformec.1352C>Tp.P451L0
2COSM1716612ATRXcentral nervous system,brain,glioma,NSc.662G>Tp.R221M0
3COSM28746IDH1central nervous system,brain,glioma,NSc.395G>Ap.R132H0
4COSM13331INSRRcentral nervous system,brain,glioma,NSc.3194G>Ap.G1065E0
5COSM20987STKLD1central nervous system,brain,glioma,NSc.416G>Ap.G139D0
6COSM39494LRFN5central nervous system,brain,glioma,glioblastoma multiformec.187G>Ap.V63I0
7COSM54520TENM2central nervous system,brain,glioma,NSc.5930C>Ap.T1977N0
8COSM28747IDH1central nervous system,brain,glioma,NSc.394C>Tp.R132C0
9COSM28749IDH1central nervous system,brain,glioma,NSc.394C>Gp.R132G0
10COSM40976SCN9Acentral nervous system,brain,glioma,glioblastoma multiformec.4862C>Tp.T1621M0
11COSM5032PTENcentral nervous system,brain,glioma,glioblastoma multiformec.394G>Ap.G132S0
12COSM550KRAScentral nervous system,brain,glioma,NSc.181C>Gp.Q61E0
13COSM40687TGM1central nervous system,brain,glioma,glioblastoma multiformec.531G>Ap.K177K0
14COSM40145GOLGA3central nervous system,brain,glioma,glioblastoma multiformec.732G>Ap.R244R0
15COSM40805ARHGAP5central nervous system,brain,glioma,glioblastoma multiformec.3371C>Tp.S1124L0
16COSM40142GNPTGcentral nervous system,brain,glioma,glioblastoma multiformec.427G>Ap.G143R0
17COSM40087CPSF7central nervous system,brain,glioma,glioblastoma multiformec.694C>Tp.L232F0
18COSM40874FRMD3central nervous system,brain,glioma,glioblastoma multiformec.346C>Tp.P116S0
19COSM11205TP53central nervous system,brain,glioma,glioblastoma multiformec.796G>Cp.G266R0
20COSM43759TP53central nervous system,brain,glioma,NSc.97-1G>Ap.?0
21COSM5296PTENcentral nervous system,brain,glioma,glioblastoma multiformec.195C>Ap.Y65*0
22COSM39512PSMD8central nervous system,brain,glioma,glioblastoma multiformec.113C>Tp.T38I0
23COSM13353PRKD3central nervous system,brain,glioma,NSc.2146G>Ap.V716M0
24COSM39922CADPScentral nervous system,brain,glioma,glioblastoma multiformec.1411G>Ap.A471T0
25COSM39786ABCA5central nervous system,brain,glioma,glioblastoma multiformec.2746C>Tp.L916F0
26COSM5911PTENcentral nervous system,brain,glioma,glioblastoma multiformec.254-3C>Ap.?0
27COSM40202IQGAP2central nervous system,brain,glioma,glioblastoma multiformec.2854G>Ap.D952N0
28COSM10758TP53central nervous system,brain,glioma,NSc.659A>Gp.Y220C0
29COSM10659TP53central nervous system,brain,glioma,NSc.817C>Tp.R273C0
30COSM39581SCN9Acentral nervous system,brain,glioma,glioblastoma multiformec.640C>Tp.R214*0
31COSM476BRAFcentral nervous system,brain,glioma,NSc.1799T>Ap.V600E0
32COSM327928H3F3Acentral nervous system,brain,glioma,glioblastoma multiformec.83A>Tp.K28M0
33COSM44169TP53central nervous system,brain,glioma,glioblastoma multiformec.614A>Cp.Y205S0
34COSM39740PDGFRAcentral nervous system,brain,glioma,glioblastoma multiformec.3149T>Cp.I1050T0
35COSM41066OSBPL2central nervous system,brain,glioma,glioblastoma multiformec.894C>Tp.I298I0
36COSM5151PTENcentral nervous system,brain,glioma,glioblastoma multiformec.1003C>Tp.R335*0
37COSM13351PINK1central nervous system,brain,glioma,NSc.644C>Tp.P215L0
38COSM21690EGFRcentral nervous system,brain,glioma,glioblastoma multiformec.1793G>Tp.G598V0
39COSM10656TP53central nervous system,brain,glioma,NSc.742C>Tp.R248W0
40COSM40737UBE2G2central nervous system,brain,glioma,glioblastoma multiformec.61C>Tp.P21S0
41COSM40071FAM43Acentral nervous system,brain,glioma,glioblastoma multiformec.611G>Ap.R204Q0
42COSM40281LRRC4central nervous system,brain,glioma,glioblastoma multiformec.327C>Tp.N109N0
43COSM39938CDH24central nervous system,brain,glioma,glioblastoma multiformec.288G>Ap.E96E0
44COSM5090PTENcentral nervous system,brain,glioma,glioblastoma multiformec.287C>Tp.P96L0
45COSM96934ATRXcentral nervous system,brain,glioma,glioblastoma multiformec.5408G>Ap.R1803H0
46COSM5121PTENcentral nervous system,brain,glioma,glioblastoma multiformec.331T>Cp.W111R0
47COSM40654SPTBN1central nervous system,brain,glioma,glioblastoma multiformec.3210C>Tp.D1070D0
48COSM6932TP53central nervous system,brain,glioma,glioblastoma multiformec.733G>Ap.G245S0
49COSM39934CDC7central nervous system,brain,glioma,glioblastoma multiformec.356G>Ap.G119E0
50COSM5137PTENcentral nervous system,brain,glioma,glioblastoma multiformec.107G>Ap.G36E0

Expression for genes affiliated with Mismatch Repair Cancer Syndrome

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Search GEO for disease gene expression data for Mismatch Repair Cancer Syndrome.

Pathways for genes affiliated with Mismatch Repair Cancer Syndrome

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Pathways related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8MLH1, MSH2
2
Show member pathways
9.8MLH1, MSH2
39.5APC, CTNNB1
49.4APC, PTEN
5
Show member pathways
9.2MLH1, MSH2, PTEN
69.1MLH1, MSH2, MSH6, PMS2
7
Show member pathways
9.1MSH2, MSH6, PTEN
89.0APC, CTNNB1, PAX3
9
Show member pathways
8.9APC, CTNNB1, PTEN
108.9APC, CTNNB1, PTEN
118.9APC, CTNNB1, PTEN
12
Show member pathways
8.9MLH1, MSH2, PMS2, PTEN
13
Show member pathways
8.7MLH1, MSH2, MSH6, PMS1, PMS2
148.6CTNNB1, MSH2, MSH6, PTEN
158.5APC, CTNNB1, MLH1, MSH2, MSH6
168.4APC, MLH1, MSH2, PMS2, PTEN
177.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN
18
Show member pathways
7.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN

GO Terms for genes affiliated with Mismatch Repair Cancer Syndrome

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Cellular components related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MutSalpha complexGO:003230110.5MSH2, MSH6
2chiasmaGO:000571210.4MLH1, PMS1
3synaptonemal complexGO:000079510.3MLH1, PMS1
4MutLalpha complexGO:003238910.1MLH1, PMS1, PMS2
5Wnt signalosomeGO:199090910.1APC, CTNNB1
6catenin complexGO:001634210.1APC, CTNNB1
7beta-catenin destruction complexGO:003087710.0APC, CTNNB1
8nucleoplasmGO:00056547.1APC, CTNNB1, MLH1, MSH2, MSH6, PAX3

Biological processes related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.5MLH1, MSH2
2meiotic mismatch repairGO:000071010.5MSH2, MSH6
3determination of adult lifespanGO:000834010.3MSH2, MSH6
4maintenance of DNA repeat elementsGO:004357010.3MSH2, MSH6
5negative regulation of DNA recombinationGO:004591010.3MSH2, MSH6
6positive regulation of helicase activityGO:005109610.2MSH2, MSH6
7somatic recombination of immunoglobulin gene segmentsGO:001644710.1MLH1, MSH2, MSH6
8isotype switchingGO:00451909.9MLH1, MSH2, MSH6
9beta-catenin destruction complex disassemblyGO:19048869.9APC, CTNNB1
10regulation of cell differentiationGO:00455959.9APC, CTNNB1
11cell fate specificationGO:00017089.9APC, CTNNB1
12pancreas developmentGO:00310169.9APC, CTNNB1
13intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.8MLH1, MSH2, MSH6
14somatic hypermutation of immunoglobulin genesGO:00164469.7MLH1, MSH2, MSH6, PMS2
15DNA repairGO:00062819.7MLH1, MSH2, MSH6
16reciprocal meiotic recombinationGO:00071319.6MLH1, MSH2, MSH6
17cellular response to DNA damage stimulusGO:00069749.6APC, MLH1, MSH2
18positive regulation of mesenchymal cell proliferationGO:00020539.5CTNNB1, MYCN
19mismatch repairGO:00062989.3MLH1, MSH2, MSH6, PMS1, PMS2
20canonical Wnt signaling pathwayGO:00600709.1APC, CTNNB1, PTEN
21response to drugGO:00424938.2APC, CTNNB1, PMS1, PMS2, PTEN

Molecular functions related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1single thymine insertion bindingGO:003214310.5MSH2, MSH6
2single guanine insertion bindingGO:003214210.5MSH2, MSH6
3oxidized purine DNA bindingGO:003235710.5MSH2, MSH6
4MutSalpha complex bindingGO:003240710.5MLH1, PMS2
5MutLalpha complex bindingGO:003240510.4MSH2, MSH6
6ADP bindingGO:004353110.3MSH2, MSH6
7guanine/thymine mispair bindingGO:003213710.2MLH1, MSH2, MSH6
8four-way junction DNA bindingGO:000040010.2MSH2, MSH6
9cadherin bindingGO:004529610.0APC, CTNNB1
10mismatched DNA bindingGO:003098310.0MSH2, MSH6, PMS1
11double-stranded DNA bindingGO:00036909.6CTNNB1, MSH2, MSH6
12magnesium ion bindingGO:00002879.5MSH2, MSH6, PTEN
13single-stranded DNA bindingGO:00036979.4MLH1, MSH2, PMS1, PMS2
14ATPase activityGO:00168878.9MLH1, MSH2, MSH6, PMS1, PMS2
15protein kinase bindingGO:00199018.6APC, CTNNB1, MSH2, PTEN
16DNA bindingGO:00036777.7CTNNB1, MSH2, MSH6, MYCN, PMS1, PMS2

Sources for Mismatch Repair Cancer Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet