MMRCS
MCID: MSM014
MIFTS: 57

Mismatch Repair Cancer Syndrome (MMRCS) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Blood diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Mismatch Repair Cancer Syndrome

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Aliases & Descriptions for Mismatch Repair Cancer Syndrome:

Name: Mismatch Repair Cancer Syndrome 52 48 70 12
Turcot Syndrome 48 24 70 27 50 68
Constitutional Mismatch Repair Deficiency Syndrome 54 70
Mismatch Repair Deficiency 48 70
Mmr Deficiency 48 70
Mmrcs 48 70
Malignant Tumors of the Central Nervous System Associated with Familial Polyposis of the Colon 48
Cns Tumors with Familial Polyposis of the Colon 48
Adenomatous Polyposis Coli with Cns Tumors 24
Brain Tumor-Polyposis Syndrome 1 70
 
Brain Tumor-Polyposis Syndrome 48
Malignant Childhood Neoplasm 68
Childhood Cancer Syndrome 70
Glioma-Polyposis Syndrome 48
Childhood Cancer 50
Cmmr-D Syndrome 54
Btp1 Syndrome 70
Cmmrds 70
Btps1 70

Characteristics:

Orphanet epidemiological data:

54
constitutional mismatch repair deficiency syndrome:
Inheritance: Autosomal recessive; Age of onset: Childhood

HPO:

64
mismatch repair cancer syndrome:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 276300
Orphanet54 ORPHA252202
MedGen37 C0265325
MeSH39 D009386

Summaries for Mismatch Repair Cancer Syndrome

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OMIM:52 Constitutional mismatch repair deficiency is a rare childhood cancer predisposition syndrome with 4 main tumor types:... (276300) more...

MalaCards based summary: Mismatch Repair Cancer Syndrome, also known as turcot syndrome, is related to colorectal cancer and retinoblastoma, and has symptoms including cafe-au-lait spot, axillary freckling and hypermelanotic macule. An important gene associated with Mismatch Repair Cancer Syndrome is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Wnt/beta-catenin Signaling Pathway in Leukemia. Affiliated tissues include brain, colon and skin, and related mouse phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased shRNA abundance (Z-score > 2).

NIH Rare Diseases:48 Turcot syndrome is a condition characterized by multiple adenomatous colon polyps, an increased risk of colorectal cancer, and an increased risk of brain cancer. it may be associated with familial adenomatous polyposis (fap) or lynch syndrome (also known as hereditary non-polyposis colorectal cancer or hnpcc). the molecular basis of most turcot syndrome is either a mutation in apc associated with fap or a mutation in one of the mismatch repair genes associated with lynch syndrome (mlh1 and pms2). the brain tumors in individuals with apc mutations are typically medulloblastoma, whereas those with mismatch repair mutations are usually glioblastoma multiforme. turcot syndrome typically follows an autosomal dominant inheritance pattern. last updated: 8/29/2012

UniProtKB/Swiss-Prot:70 Mismatch repair cancer syndrome: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.

Wikipedia:71 Mismatch repair cancer syndrome (MMRCS) is a cancer syndrome associated with biallelic DNA mismatch... more...

Related Diseases for Mismatch Repair Cancer Syndrome

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Diseases related to Mismatch Repair Cancer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer29.3APC, CTNNB1, MLH1, MSH2, MSH6, PMS1
2retinoblastoma11.4
3adenomatous polyposis coli11.3
4mlh1-related turcot syndrome11.1
5msh2-related turcot syndrome11.1
6msh6-related turcot syndrome11.1
7pms2-related turcot syndrome11.1
8glioma susceptibility 111.1
9neurofibromatosis, type 111.1
10childhood leukemia11.0
11neuroblastoma10.9
12beckwith-wiedemann syndrome10.7
13adrenal carcinoma10.7
14li-fraumeni syndrome10.5
15brain tumor, childhood10.5
16cask-related disorders10.3MSH6, PMS2
17skin melanoma10.2MLH1, MSH2
18htr2a-related altered drug metabolism10.2APC, MLH1
19aorta atresia10.2MLH1, MSH2
20hereditary sensory and autonomic neuropathy with deafness and global delay10.2APC, MLH1
21trypanosomiasis10.2MLH1, MSH6
22endometrial squamous cell carcinoma10.2APC, MLH1
23factor xiii deficiency10.2MSH2, PMS1
24bacteremia10.2MSH6, PMS2
25lynch syndrome10.2
26macular degeneration, early-onset10.1APC, CTNNB1
27neurocutaneous melanosis, somatic10.1MLH1, MSH2
28papilloma10.1CTNNB1, MLH1
29benign fibrous mesothelioma10.1MLH1, MSH2, MSH6
30neuroretinitis10.1MLH1, MSH2, MSH6
31skin papilloma10.1MLH1, MSH2, MSH6
32dfnb110.1APC, CTNNB1
33cardiomyopathy, dilated, 1r10.1MSH2, MSH6
34bronchogenic cyst10.1APC, PTEN
35diabetes mellitus, noninsulin-dependent, 210.1APC, CTNNB1
36familial hypopituitarism10.1APC, MLH1, MSH2
37bronchiectasis oligospermia10.1APC, PTEN
38autoimmune autonomic ganglionopathy10.1APC, MSH2, MSH6
39fibrolamellar carcinoma10.1CTNNB1, MLH1, MSH2
40collecting duct carcinoma10.0MLH1, MSH2, PAX3
41breast ductal carcinoma10.0CTNNB1, PTEN
42congenital symblepharon10.0CTNNB1, MLH1, MSH2
43oral squamous cell carcinoma10.0CTNNB1, MLH1, MSH2
44large intestine adenoma10.0MLH1, MSH2, MSH6, PMS2
45neuropathy, distal hereditary motor, type viib10.0MLH1, MSH2, MSH6, PMS2
46neurofibromatosis-noonan syndrome10.0MLH1, MSH2, MSH6, PMS2
47wolffian duct adenoma10.0MLH1, MSH2, MSH6, PMS2
48adult syndrome10.0CTNNB1, PTEN
49wagr syndrome10.0CTNNB1, MLH1, MSH2
50seborrheic dermatitis10.0MLH1, MSH2, MSH6, PMS2

Graphical network of the top 20 diseases related to Mismatch Repair Cancer Syndrome:



Diseases related to mismatch repair cancer syndrome

Symptoms & Phenotypes for Mismatch Repair Cancer Syndrome

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Symptoms by clinical synopsis from OMIM:

276300

Clinical features from OMIM:

276300

Human phenotypes related to Mismatch Repair Cancer Syndrome:

 64 (show all 13)
id Description HPO Frequency HPO Source Accession
1 cafe-au-lait spot64 HP:0000957
2 axillary freckling64 HP:0000997
3 hypermelanotic macule64 HP:0001034
4 agenesis of corpus callosum64 HP:0001274
5 abnormality of abdomen morphology64 HP:0001438
6 leukemia64 HP:0001909
7 lymphoma64 HP:0002665
8 basal cell carcinoma64 HP:0002671
9 rhabdomyosarcoma64 HP:0002859
10 medulloblastoma64 HP:0002885
11 ependymoma64 HP:0002888
12 neuroblastoma64 HP:0003006
13 glioblastoma64 HP:0100843

GenomeRNAi Phenotypes related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-39.2MLH1, MSH2, MSH6, PMS1, PMS2
2GR00366-A-1929.2APC, CTNNB1, MLH1

MGI Mouse Phenotypes related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

41 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9APC, CTNNB1, PAX3, PTEN
2MP:00053798.0APC, CTNNB1, MLH1, PAX3, PMS2, PTEN
3MP:00053898.0APC, CTNNB1, MLH1, MYCN, PMS2, PTEN
4MP:00053677.9APC, CTNNB1, MYCN, PAX3, PTEN
5MP:00053717.9APC, CTNNB1, MYCN, PAX3, PTEN
6MP:00053887.9CTNNB1, MLH1, MYCN, PAX3, PTEN
7MP:00053917.6APC, CTNNB1, MLH1, MYCN, PAX3, PTEN
8MP:00107717.5APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
9MP:00053707.4APC, CTNNB1, MYCN, PAX3, PMS2, PTEN
10MP:00020067.1APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
11MP:00053977.1APC, CTNNB1, MSH2, MYCN, PAX3, PMS2
12MP:00053816.8APC, CTNNB1, MLH1, MSH2, MYCN, PAX3
13MP:00053766.6APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
14MP:00107686.5APC, CTNNB1, MLH1, MSH2, MSH6, MYCN
15MP:00053846.5APC, CTNNB1, MLH1, MSH2, MSH6, MYCN

Drugs & Therapeutics for Mismatch Repair Cancer Syndrome

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Drugs for Mismatch Repair Cancer Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 70)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Capecitabineapproved, investigationalPhase 3, Phase 21342154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
2
FluorouracilapprovedPhase 3, Phase 2185651-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
3
Oxaliplatinapproved, investigationalPhase 3, Phase 2146061825-94-35310940, 9887054, 6857599, 9887054, 43805
Synonyms:
CHEMBL1201055
CID9887054
D01790
DACPLAT
Diaminocyclohexane Oxalatoplatinum
Eloxatin
Eloxatin (TN)
Elplat
Foloxatine
L-OHP
Oxalatoplatin
 
Oxalatoplatinum
Oxaliplatin (JAN/USAN/INN)
Oxaliplatin [Usan:Inn:Ban]
Oxaliplatino [Spanish]
Oxaliplatinum [Latin]
Oxaloplatine [French]
Oxaloplatino [Spanish]
Transplatin
oxaliplatin
oxaliplatine
oxaliplatino
oxaliplatinum
4
LevoleucovorinapprovedPhase 372868538-85-2
Synonyms:
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-5-formyltetrahydrofolic acid
(6S)-Folinic acid
(6S)-Leucovorin
 
(S)-Leucovorin
Citrovorum factor
L-Folinic acid
Levofolene
Levofolinic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
5
Aspirinapproved, vet_approvedPhase 3115250-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalicylsäure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide acetylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
Entericin
Enterophen
 
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
acide 2-(acétyloxy)benzoïque
acide acétylsalicylique
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
salicylic acid acetate
ácido acetilsalicílico
6
leucovorinapproved, NutraceuticalPhase 3, Phase 2, Phase 1323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
7
Folic Acidapproved, nutraceutical, vet_approvedPhase 3, Phase 1, Phase 2439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
8Peripheral Nervous System AgentsPhase 3, Phase 123689
9Immunosuppressive AgentsPhase 3, Phase 1, Phase 213086
10AntibodiesPhase 3, Phase 1, Phase 26394
11Antimetabolites, AntineoplasticPhase 3, Phase 2, Phase 17361
12Cyclooxygenase InhibitorsPhase 3, Phase 12870
13Antibodies, MonoclonalPhase 3, Phase 1, Phase 24039
14Vitamin B ComplexPhase 3, Phase 1, Phase 24337
15ImmunoglobulinsPhase 3, Phase 1, Phase 26394
16Analgesics, Non-NarcoticPhase 3, Phase 16501
17Anti-Inflammatory Agents, Non-SteroidalPhase 3, Phase 14443
18AntimetabolitesPhase 3, Phase 2, Phase 112054
19Antirheumatic AgentsPhase 3, Phase 1, Phase 210956
20AnalgesicsPhase 3, Phase 111733
21Anti-Inflammatory AgentsPhase 3, Phase 110729
22Protective AgentsPhase 37443
23Trace ElementsPhase 36001
24Acetylsalicylic acid lysinatePhase 312
25MicronutrientsPhase 36001
26VitaminsPhase 35282
27Platelet Aggregation InhibitorsPhase 32516
28Fibrinolytic AgentsPhase 32388
29AntidotesPhase 31071
30Bone Density Conservation AgentsPhase 33376
31HematinicsPhase 31684
32Calcium, DietaryPhase 35713
33AntipyreticsPhase 31605
34ColaNutraceuticalPhase 31946
35Vitamin B9NutraceuticalPhase 3, Phase 1, Phase 24392
36FolateNutraceuticalPhase 3, Phase 1, Phase 24392
37
PalbociclibapprovedPhase 2127571190-30-211431660, 5005498, 5330286
Synonyms:
2euf
571190-30-2
6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
AC1NS8RV
CHEMBL189963
CID5330286
EC-000.2350
 
Ibrance
Kinome_3823
Kinome_3824
LQQ
PD 0332991
PD 332991, PD 0332991, PD0332991
PD-0332991
PD-332991
PD0332991
Palbociclib
S1116_Selleck
38
Epinephrineapproved, vet_approvedPhase 298551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
39
PertuzumabapprovedPhase 2127145040-37-5, 380610-27-52540
Synonyms:
2C4 Antibody
380610-27-5
D05446
Immunoglobulin G1, anti-(human v (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer
LS-185920
MOAB 2C4
MOAB2C4
Monoclonal Antibody 2C4
 
Omnitarg
Perjeta
Pertuzumab
Pertuzumab (USAN/INN)
Pertuzumab (genetical recombination)
Pertuzumab (genetical recombination) (JAN)
pertuzumab
rhuMAb 2C4
rhuMAb-2C4
40
OsimertinibapprovedPhase 2591421373-65-071496458
Synonyms:
Mereletinib
 
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Tagrisso
mereletinib
41
TrametinibapprovedPhase 2131871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
42
DabrafenibapprovedPhase 28444462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
43
ThioguanineapprovedPhase 1, Phase 283154-42-72723601
Synonyms:
154-42-7
2 Amino 6 Purinethiol
2-Amino 6MP
2-Amino 6mp
2-Amino-1,7-dihydro-6H-purin-6-thion
2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]
2-Amino-1,7-dihydro-6H-purine-6-thione
2-Amino-6-MP
2-Amino-6-mercaptopurine
2-Amino-6-merkaptopurin
2-Amino-6-merkaptopurin [Czech]
2-Amino-6-purinethiol
2-Amino-9H-purine-6-thiol
2-Aminopurin-6-thiol
2-Aminopurin-6-thiol [Czech]
2-Aminopurine-6(1H)-thione
2-Aminopurine-6-thiol
2-Thioguanine
2-amino-1,9-Dihydropurine-6-thione
2-amino-1H-purine-6(7H)-thione
2-amino-3,7-dihydropurine-6-thione
2-aminopurine-6-thiol
5580-03-0
6 Thioguanine
6-Mercapto-2-aminopurine
6-Mercaptoguanine
6-TG
6-Thioguanine
6-Thioguanine (6-TG)
6-Thioguanine, Thioguanine
A4660_SIGMA
A4882_SIGMA
AC-11125
AC1MC379
AI3-26078
AKOS003389499
BSPBio_001994
BW 5071
C07648
C5H7N5S
CCRIS 8997
CHEBI:136864
CHEMBL727
CID2723601
D013866
D08603
DB00352
DX4
DivK1c_000428
EINECS 205-827-2
FT-0083572
Glaxo Wellcome Brand of Thioguanine
Glaxo Wellcome Brand of Tioguanine
GlaxoSmithKline Brand of Thioguanine
GlaxoSmithKline Brand of Tioguanine
Guanine, thio- (VAN)
HMS1921E09
HMS2092M11
HMS501F10
HSDB 2504
I14-1541
IDI1_000428
KBio1_000428
KBio2_000715
KBio2_002476
KBio2_003283
KBio2_005044
 
KBio2_005851
KBio2_007612
KBio3_001494
KBio3_002954
KBioGR_001452
KBioGR_002476
KBioSS_000715
KBioSS_002483
LS-888
LT00455187
Lanvis
Lanvis (TN)
MLS001333131
MLS001333132
MolPort-000-929-106
MolPort-001-813-204
MolPort-003-984-174
NCGC00094792-01
NCGC00094792-02
NCGC00094792-03
NCI60_041643
NCIOpen2_004153
NINDS_000428
NSC 752
NSC-752
NSC752
S1774_Selleck
SBB067147
SMP2_000326
SMR000857244
SPBio_000849
SPECTRUM1500573
ST50298831
Spectrum2_000695
Spectrum3_000577
Spectrum4_000926
Spectrum5_001455
Spectrum_000235
T0212
TG
THG
Tabloid
ThG
Thioguanin GSK
Thioguanin-GSK
ThioguaninGSK
Thioguanine
Thioguanine Hemihydrate
Thioguanine Monosodium Salt
Thioguanine Tabloid
Thioguanine [USAN:BAN]
Tioguanin
Tioguanina
Tioguanina Wellcome
Tioguanina [INN-Spanish]
Tioguanine
Tioguanine (INN)
Tioguanine GlaxoSmithKline Brand
Tioguaninum
Tioguaninum [INN-Latin]
UNII-FTK8U1GZNX
UNII-WIX31ZPX66
WLN: T56 BNM FYM INJ FUS HZ
Wellcome Brand of Thioguanine
Wellcome U3B
ZINC18085533
cMAP_000061
purine antimetabolite: antimetabolite: inhibits nucleic acid replication
thioguanine
44
MethotrexateapprovedPhase 1, Phase 215511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
45
Trastuzumabapproved, investigationalPhase 2784180288-69-19903
Synonyms:
180288-69-1
Anti HER2
Anti-erbB2 Monoclonal Antibody
D03257
HER2 Monoclonal Antibody
Herceptin
 
Herceptin (TN)
Ig gamma-1 chain C region
Trastuzumab
Trastuzumab (INN)
Trastuzumab (genetical recombination)
Trastuzumab (genetical recombination) (JAN)
trastuzumab
46
Sunitinibapproved, investigationalPhase 2510341031-54-7, 557795-19-45329102
Synonyms:
(2S)-2-hydroxybutanedioic acid
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
326914-13-0
341031-54-7
5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
557795-19-4
AC1NS62J
AC1O5CMQ
AKOS005145765
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
CHEBI:38940
CHEBI:550864
CHEMBL1567
CHEMBL535
CID5329102
CID6456015
D06402
D08552
DB01268
DB07417
EN002687
FT-0083555
FT-0083556
I01-1229
K00588a
KS-5022
LS-186078
LS-187023
LS-187648
MolPort-003-986-763
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
 
NSC736511
NSC750690
PDGF TK antagonist
PHA-290940AD
PNU-290940AD
S1042_Selleck
ST51053712
SU 011248
SU 11248
SU-010398
SU-011248 L-malate salt
SU-11248
SU-11248 L-malate salt
SU-11248J
SU-12662
SU010398
SU011248
SU011248 L-malate salt
SU11248
Su-011248
Sunitanib
Sunitinib
Sunitinib (INN)
Sunitinib (free base)
Sunitinib malate
Sunitinib malate (JAN/USAN)
Sunitinib malate [USAN]
Sunitinibum
Sutent
Sutent (TN)
Sutent, SU-11248
TL8002546
UNII-LVX8N1UT73
UNII-V99T50803M
sunitinib
sunitinibum
47
Dasatinibapproved, investigationalPhase 2285302962-49-83062316
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
AC1MI3ET
AC1Q2P0C
AmbotzLS-1203
Anhydrous dasatinib
BCB03_000715
BMS 354825
BMS dasatinib
BMS-354825
BMS-354825, Sprycel, BMS354825, Dasatinib
BMS354825
C488369
CHEBI:49375
CHEMBL1421
CID3062316
D03658
DB01254
Dasatinib
Dasatinib (USAN)
Dasatinib (anh.)
Dasatinib [USAN]
Dasatinib anhydrous
Dasatinib, BMS 354825
Dasatinibum
EC-000.2122
 
EN002710
FT-0084503
I14-1972
Kinome_3650
LS-186641
LS-187028
LS-187773
MolPort-003-846-143
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
NSC-732517
NSC732517
S1021_Selleck
SPRYCEL (TN)
Sprycel
Spyrcel
UNII-X78UG0A0RN
anh. dasatinib
dasatinib
dasatinib (anhydrous)
dasatinibum
nchembio.117-comp11
nchembio.162-comp4
nchembio.332-comp1
48
nivolumabapprovedPhase 1, Phase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
49
CrizotinibapprovedPhase 2104877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-crizotinib
Crizotinib
 
Crizotinibum
PF-02341066
Xalkori
crizotinib
50
Bevacizumabapproved, investigationalPhase 22020216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and OverRecruitingNCT02355379Phase 3
2Finding the Best Dose of Aspirin to Prevent Lynch Syndrome CancersNot yet recruitingNCT02497820Phase 3
3Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair or Microsatellite InstabilityNot yet recruitingNCT02912559Phase 3
4Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch SyndromeNot yet recruitingNCT02813824Phase 3
5Pilot Study of Nivolumab in Pediatric Patients With Hypermutant CancersRecruitingNCT02992964Phase 1, Phase 2
6Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004RecruitingNCT03050814Phase 2
7NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple MyelomaRecruitingNCT02465060Phase 2
8Thiopurine EnhAnced Maintenance TherapyRecruitingNCT02912676Phase 1, Phase 2
9Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch SyndromeRecruitingNCT02052908Phase 1
10I-Scan For Colon Polyp Detection In HNPCCUnknown statusNCT01823471
11Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, or Hypermutated Brain TumorsRecruitingNCT02359565
12Familial Investigations of Childhood Cancer PredispositionRecruitingNCT03050268
13Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment SelectionRecruitingNCT02750657
14Familial Cancer Registry and DNA BankRecruitingNCT02083224
15Adherence to Colon Cancer Screening (ACCS)RecruitingNCT02112747
16Phenotyping of Small Bowel AdenocarcinomaActive, not recruitingNCT02976090
17Inherited Susceptible Genes Among Epithelial Ovarian CancerNot yet recruitingNCT03015376
18Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal CancerNot yet recruitingNCT03047226
19Biomarkers in Samples From Patients With Endometrial CancerNot yet recruitingNCT01199250

Search NIH Clinical Center for Mismatch Repair Cancer Syndrome

Genetic Tests for Mismatch Repair Cancer Syndrome

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Genetic tests related to Mismatch Repair Cancer Syndrome:

id Genetic test Affiliating Genes
1 Turcot Syndrome27 24 PMS2

Anatomical Context for Mismatch Repair Cancer Syndrome

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MalaCards organs/tissues related to Mismatch Repair Cancer Syndrome:

36
Brain, Colon, Skin

Publications for Mismatch Repair Cancer Syndrome

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Articles related to Mismatch Repair Cancer Syndrome:

idTitleAuthorsYear
1
Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome. (23483711)
2013

Variations for Mismatch Repair Cancer Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Mismatch Repair Cancer Syndrome:

70
id Symbol AA change Variation ID SNP ID
1MLH1p.Met35AsnVAR_043388rs121912965
2PMS2p.Glu705LysVAR_012974rs267608161
3PMS2p.Ser46IleVAR_066838rs121434629
4PMS2p.Arg107TrpVAR_078521
5PMS2p.Cys115GlyVAR_078522
6PMS2p.Ser815LeuVAR_078537

Clinvar genetic disease variations for Mismatch Repair Cancer Syndrome:

5 (show all 30)
id Gene Variation Type Significance SNP ID Assembly Location
1MLH1NM_ 000249.3(MLH1): c.1852_ 1854delAAG (p.Lys618del)deletionPathogenicrs63751247GRCh37Chr 3, 37089130: 37089132
2MLH1NM_ 000249.3(MLH1): c.676C> T (p.Arg226Ter)SNVPathogenicrs63751615GRCh37Chr 3, 37053589: 37053589
3MLH1NM_ 000249.3(MLH1): c.199G> T (p.Gly67Trp)SNVPathogenicrs63750206GRCh37Chr 3, 37038192: 37038192
4MLH1MLH1, EX16DELdeletionPathogenic
5MLH1NM_ 000249.3(MLH1): c.1942C> T (p.Pro648Ser)SNVPathogenicrs63750899GRCh37Chr 3, 37090053: 37090053
6MLH1MLH1, 2-BP DEL, 593AGdeletionPathogenic
7MLH1NM_ 000249.3(MLH1): c.104_ 105delTGinsAC (p.Met35Asn)indelPathogenicrs121912965GRCh37Chr 3, 37035142: 37035143
8MSH2MSH2, EX1-6 DELdeletionPathogenic
9MSH2NM_ 000251.2(MSH2): c.454delA (p.Met152Cysfs)deletionPathogenicrs63751449GRCh37Chr 2, 47637320: 47637320
10PMS2NM_ 000535.6(PMS2): c.2002A> G (p.Ile668Val)SNVPathogenicrs869320619GRCh37Chr 7, 6026394: 6026394
11MSH6NM_ 000179.2(MSH6): c.3311_ 3312delTT (p.Phe1104Trpfs)deletionPathogenicrs267608092GRCh37Chr 2, 48030697: 48030698
12MSH6MSH6, TRP1024TERundetermined variantPathogenic
13MSH6MSH6, 3-BP DEL, NT3609deletionPathogenic
14MSH6NM_ 000179.2(MSH6): c.3633dupT (p.Val1212Cysfs)duplicationPathogenicrs587776706GRCh37Chr 2, 48032833: 48032833
15MSH6MSH6, 1-BP INS, 1596TinsertionPathogenic
16MSH6MSH6, 1-BP DEL, 3261CdeletionPathogenic
17MLH1NM_ 000249.3(MLH1): c.1943C> T (p.Pro648Leu)SNVPathogenicrs63750610GRCh37Chr 3, 37090054: 37090054
18MSH2NM_ 000251.2(MSH2): c.1662-1G> ASNVPathogenicrs267607970GRCh37Chr 2, 47698103: 47698103
19PMS2NM_ 000535.6(PMS2): c.1145-?_ 2445+?deldeletionPathogenic
20PMS2NM_ 000535.6(PMS2): c.1169_ 1170ins20 (p.?)insertionPathogenicrs587779327GRCh37Chr 7, 6027226: 6027227
21PMS2NM_ 000535.6(PMS2): c.1306dupA (p.Ser436Lysfs)duplicationPathogenicrs63750106GRCh37Chr 7, 6027090: 6027090
22PMS2NM_ 000535.6(PMS2): c.182delA (p.Tyr61Leufs)deletionPathogenicrs63750793GRCh37Chr 7, 6043671: 6043671
23PMS2NM_ 000535.6(PMS2): c.1927C> T (p.Gln643Ter)SNVPathogenicrs63751422GRCh37Chr 7, 6026469: 6026469
24PMS2NM_ 000535.6(PMS2): c.2361_ 2364delCTTC (p.Phe788Cysfs)deletionPathogenicrs267608160GRCh37Chr 7, 6017300: 6017303
25PMS2NM_ 000535.6(PMS2): c.400C> T (p.Arg134Ter)SNVPathogenicrs63750871GRCh37Chr 7, 6042221: 6042221
26PMS2NM_ 000535.6(PMS2): c.1221delG (p.Thr408Leufs)deletionPathogenicrs587776715GRCh37Chr 7, 6027175: 6027175
27PMS2NM_ 000535.6(PMS2): c.2404C> T (p.Arg802Ter)SNVPathogenicrs63751466GRCh37Chr 7, 6017260: 6017260
28PMS2NM_ 000535.6(PMS2): c.1731_ 1732delGCinsAGT (p.Arg578Valfs)indelPathogenicrs1057515572GRCh38Chr 7, 5987033: 5987034
29PMS2NM_ 000535.6(PMS2): c.137G> T (p.Ser46Ile)SNVLikely pathogenicrs121434629GRCh37Chr 7, 6045549: 6045549
30PMS2NM_ 000535.6(PMS2): c.219T> A (p.Cys73Ter)SNVPathogenicrs121434630GRCh37Chr 7, 6043634: 6043634

Cosmic variations for Mismatch Repair Cancer Syndrome:

8 (show top 50)    (show all 1939)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM54395NOP9central nervous system,brain,glioma,glioblastoma multiformec.1625G>Ap.R542H10
2COSM54397LINC01551central nervous system,brain,glioma,glioblastoma multiformec.48G>Ap.R16R10
3COSM54487DLEC1central nervous system,brain,glioma,glioblastoma multiformec.2614C>Tp.R872C10
4COSM54498USO1central nervous system,brain,glioma,glioblastoma multiformec.749C>Tp.A250V10
5COSM39706ASH1Lcentral nervous system,brain,glioma,glioblastoma multiformec.3127G>Cp.G1043R10
6COSM33702PTENcentral nervous system,brain,glioma,glioblastoma multiformec.530A>Gp.Y177C10
7COSM5089PTENcentral nervous system,brain,glioma,glioblastoma multiformec.517C>Tp.R173C10
8COSM40610SLC2A1central nervous system,brain,glioma,glioblastoma multiformec.224G>Ap.G75E10
9COSM28746IDH1central nervous system,brain,glioma,glioblastoma multiformec.395G>Ap.R132H10
10COSM763PIK3CAcentral nervous system,brain,glioma,glioblastoma multiformec.1633G>Ap.E545K10
11COSM39272XPO7central nervous system,brain,glioma,glioblastoma multiformec.1157G>Ap.R386Q10
12COSM29340EGFRcentral nervous system,brain,glioma,glioblastoma multiformec.818C>Ap.T273N10
13COSM10790TP53central nervous system,brain,glioma,glioblastoma multiformec.455C>Tp.P152L10
14COSM45035TP53central nervous system,brain,glioma,glioblastoma multiformec.761T>Gp.I254S10
15COSM40117FUBP1central nervous system,brain,glioma,glioblastoma multiformec.842C>Tp.P281L10
16COSM39671KCNA7central nervous system,brain,glioma,glioblastoma multiformec.828C>Tp.I276I10
17COSM5177PTENcentral nervous system,brain,glioma,glioblastoma multiformec.240A>Tp.K80N10
18COSM28747IDH1central nervous system,brain,glioma,glioblastoma multiformec.394C>Tp.R132C10
19COSM43868TP53central nervous system,brain,glioma,glioblastoma multiformec.689C>Tp.T230I10
20COSM21446PIK3CAcentral nervous system,brain,glioma,glioblastoma multiformec.3012G>Tp.M1004I10
21COSM40698TMEM38Acentral nervous system,brain,glioma,glioblastoma multiformec.151C>Tp.P51S10
22COSM39310GKcentral nervous system,brain,glioma,glioblastoma multiformec.1205C>Tp.A402V10
23COSM40959ESR1central nervous system,brain,glioma,glioblastoma multiformec.1022C>Tp.S341L10
24COSM5208PTENcentral nervous system,brain,glioma,glioblastoma multiformec.1007A>Tp.Y336F10
25COSM39991CREB1central nervous system,brain,glioma,glioblastoma multiformec.711C>Tp.S237S10
26COSM327928H3F3Acentral nervous system,brain,glioma,glioblastoma multiformec.83A>Tp.K28M10
27COSM40041DSTcentral nervous system,brain,glioma,glioblastoma multiformec.2431G>Ap.A811T10
28COSM5219PTENcentral nervous system,brain,glioma,glioblastoma multiformec.388C>Gp.R130G10
29COSM5103PTENcentral nervous system,brain,glioma,glioblastoma multiformec.466G>Ap.G156R10
30COSM776PIK3CAcentral nervous system,brain,glioma,glioblastoma multiformec.3140A>Tp.H1047L10
31COSM39861ATP7Bcentral nervous system,brain,glioma,glioblastoma multiformec.4072G>Ap.A1358T10
32COSM39653A2Mcentral nervous system,brain,glioma,glioblastoma multiformec.917C>Ap.T306N10
33COSM39977VPS13Bcentral nervous system,brain,glioma,glioblastoma multiformec.1913C>Tp.T638I10
34COSM40289CD163L1central nervous system,brain,glioma,glioblastoma multiformec.4039+1G>Ap.?10
35COSM21687EGFRcentral nervous system,brain,glioma,glioblastoma multiformec.866C>Tp.A289V10
36COSM40484POLR3Ecentral nervous system,brain,glioma,glioblastoma multiformec.2052G>Ap.E684E10
37COSM40854RPS6KB2central nervous system,brain,glioma,glioblastoma multiformec.90C>Tp.P30P10
38COSM44202TP53central nervous system,brain,glioma,glioblastoma multiformec.550G>Tp.D184Y10
39COSM39287LAMA1central nervous system,brain,glioma,glioblastoma multiformec.6329G>Ap.R2110H10
40COSM10758TP53central nervous system,brain,glioma,glioblastoma multiformec.659A>Gp.Y220C10
41COSM39546SLC30A9central nervous system,brain,glioma,glioblastoma multiformec.962G>Ap.G321D10
42COSM40843PAPLNcentral nervous system,brain,glioma,glioblastoma multiformec.1509G>Ap.V503V10
43COSM96935ATRXcentral nervous system,brain,glioma,glioblastoma multiformec.789G>Ap.W263*10
44COSM5139PTENcentral nervous system,brain,glioma,glioblastoma multiformec.263A>Gp.Y88C10
45COSM39409RB1central nervous system,brain,glioma,glioblastoma multiformec.265-1G>Ap.?10
46COSM40695ANO5central nervous system,brain,glioma,glioblastoma multiformec.1258G>Ap.E420K10
47COSM5185PTENcentral nervous system,brain,glioma,glioblastoma multiformec.69A>Cp.L23F10
48COSM5042PTENcentral nervous system,brain,glioma,glioblastoma multiformec.182A>Gp.H61R10
49COSM10704TP53central nervous system,brain,glioma,glioblastoma multiformec.844C>Tp.R282W10
50COSM39254AMMECR1Lcentral nervous system,brain,glioma,glioblastoma multiformec.689C>Tp.T230I10

Expression for genes affiliated with Mismatch Repair Cancer Syndrome

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Search GEO for disease gene expression data for Mismatch Repair Cancer Syndrome.

Pathways for genes affiliated with Mismatch Repair Cancer Syndrome

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Pathways related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8MLH1, MSH2
29.5APC, CTNNB1
39.5APC, CTNNB1
49.5APC, CTNNB1
59.5APC, CTNNB1
69.4APC, PTEN
79.4MLH1, MSH2, MSH6
8
Show member pathways
9.2MLH1, MSH2, PTEN
99.1MLH1, MSH2, MSH6, PMS2
109.1MSH2, MSH6, PTEN
119.0APC, CTNNB1, PAX3
128.9APC, CTNNB1, PTEN
138.9APC, CTNNB1, PTEN
14
Show member pathways
8.9MLH1, MSH2, PMS2, PTEN
15
Show member pathways
8.7MLH1, MSH2, MSH6, PMS1, PMS2
168.6CTNNB1, MSH2, MSH6, PTEN
178.5APC, CTNNB1, MLH1, MSH2, MSH6
188.4APC, MLH1, MSH2, PMS2, PTEN
197.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN
20
Show member pathways
7.9APC, CTNNB1, MLH1, MSH2, MSH6, PTEN

GO Terms for genes affiliated with Mismatch Repair Cancer Syndrome

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Cellular components related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:003230010.6MSH2, PMS2
2MutSalpha complexGO:003230110.6MSH2, MSH6
3beta-catenin destruction complexGO:003087710.4APC, CTNNB1
4catenin complexGO:001634210.4APC, CTNNB1
5MutLalpha complexGO:003238910.2MLH1, PMS1, PMS2
6Wnt signalosomeGO:19909099.5APC, CTNNB1
7nucleoplasmGO:00056547.9APC, CTNNB1, MLH1, MSH2, MSH6, PAX3
8nucleusGO:00056346.0APC, CTNNB1, MLH1, MSH2, MSH6, MYCN

Biological processes related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1determination of adult lifespanGO:000834010.4MSH2, MSH6
2positive regulation of isotype switching to IgA isotypesGO:004829810.4MLH1, MSH2
3positive regulation of isotype switching to IgG isotypesGO:004830410.4MLH1, MSH2
4maintenance of DNA repeat elementsGO:004357010.4MSH2, MSH6
5negative regulation of DNA recombinationGO:004591010.4MSH2, MSH6
6positive regulation of helicase activityGO:005109610.4MSH2, MSH6
7beta-catenin destruction complex disassemblyGO:190488610.3APC, CTNNB1
8intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.1MLH1, MSH2, MSH6
9isotype switchingGO:004519010.1MLH1, MSH2, MSH6
10positive regulation of cell deathGO:00109429.9APC, MYCN
11somatic recombination of immunoglobulin genes involved in immune responseGO:00022049.8MLH1, MSH2
12positive regulation of mesenchymal cell proliferationGO:00020539.8CTNNB1, MYCN
13canonical Wnt signaling pathwayGO:00600709.6APC, CTNNB1, PTEN
14DNA repairGO:00062819.3MLH1, MSH2, MSH6, PMS1, PMS2
15somatic recombination of immunoglobulin gene segmentsGO:00164479.3MLH1, MSH2, MSH6
16mismatch repairGO:00062989.3MLH1, MSH2, MSH6, PMS1, PMS2
17somatic hypermutation of immunoglobulin genesGO:00164469.3MLH1, MSH2, MSH6, PMS2
18cellular response to DNA damage stimulusGO:00069749.0APC, MLH1, MSH2, MSH6, PMS1, PMS2
19response to drugGO:00424938.9CTNNB1, PMS1, PMS2, PTEN

Molecular functions related to Mismatch Repair Cancer Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1ADP bindingGO:004353110.5MSH2, MSH6
2MutSalpha complex bindingGO:003240710.5MLH1, PMS2
3four-way junction DNA bindingGO:000040010.4MSH2, MSH6
4MutLalpha complex bindingGO:003240510.4MSH2, MSH6
5oxidized purine DNA bindingGO:003235710.4MSH2, MSH6
6single guanine insertion bindingGO:003214210.3MSH2, MSH6
7single thymine insertion bindingGO:003214310.3MSH2, MSH6
8guanine/thymine mispair bindingGO:003213710.1MLH1, MSH2, MSH6
9double-stranded DNA bindingGO:00036909.9CTNNB1, MSH2, MSH6
10magnesium ion bindingGO:00002879.8MSH2, MSH6, PTEN
11ATPase activityGO:00168879.4MLH1, MSH2, MSH6, PMS1, PMS2
12mismatched DNA bindingGO:00309839.3MLH1, MSH2, MSH6, PMS1, PMS2
13protein kinase bindingGO:00199019.1APC, CTNNB1, MSH2, PTEN
14single-stranded DNA bindingGO:00036979.0MLH1, MSH2, PMS1, PMS2
15DNA bindingGO:00036778.3CTNNB1, MSH2, MSH6, MYCN, PMS1, PMS2

Sources for Mismatch Repair Cancer Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet