MCID: MTC028
MIFTS: 21

Mitochondrial Cardiomyopathy malady

Cardiovascular diseases category

Summaries for Mitochondrial Cardiomyopathy

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32MalaCards
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MalaCards: Mitochondrial Cardiomyopathy is related to myopathy and kearns-sayre syndrome. An important gene associated with Mitochondrial Cardiomyopathy is MT-TL1 (mitochondrially encoded tRNA leucine 1 (UUA/G)), and among its related pathways is tRNA Aminoacylation. The compounds rrna and l-alanine have been mentioned in the context of this disorder.

Aliases & Classifications for Mitochondrial Cardiomyopathy

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20GeneTests, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

mitochondrial cardiomyopathy 20 22


Related Diseases for Mitochondrial Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases related to Mitochondrial Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1myopathy30.1CS
2kearns-sayre syndrome10.2
3keshan disease10.1
4friedreich ataxia10.0
5melas syndrome10.0
6muscular atrophy10.0
7hypertrophic cardiomyopathy10.0
8congestive heart failure10.0
9diabetes mellitus10.0
10ischemia10.0
11kidney disease10.0
12lactic acidosis10.0
13mitochondrial encephalomyopathy10.0
14pericardial effusion10.0
15respiratory failure10.0
16restrictive cardiomyopathy10.0
17spinal muscular atrophy10.0
183 methylglutaconic aciduria type i10.0

Graphical network of diseases related to Mitochondrial Cardiomyopathy:



Diseases related to mitochondrial cardiomyopathy

Clinical Features for Mitochondrial Cardiomyopathy

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Drugs & Therapeutics for Mitochondrial Cardiomyopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mitochondrial Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Mitochondrial Cardiomyopathy

Search NIH Clinical Center for Mitochondrial Cardiomyopathy

Search CenterWatch for Mitochondrial Cardiomyopathy

Genetic Tests for Mitochondrial Cardiomyopathy

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20GeneTests, 22GTR
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Genetic tests related to Mitochondrial Cardiomyopathy:

id Genetic test Affiliating Genes
1 Mitochondrial Cardiomyopathy20 MT-TL1
2 Cardiomyopathy, Mitochondrial22

Anatomical Context for Mitochondrial Cardiomyopathy

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Animal Models for Mitochondrial Cardiomyopathy or affiliated genes

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Publications for Mitochondrial Cardiomyopathy

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Genetic Variations for Mitochondrial Cardiomyopathy

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Expression for genes affiliated with Mitochondrial Cardiomyopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitochondrial Cardiomyopathy

Search GEO for disease gene expression data for Mitochondrial Cardiomyopathy.

Pathways for genes affiliated with Mitochondrial Cardiomyopathy

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53Reactome, 29KEGG
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Pathways related to Mitochondrial Cardiomyopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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8.2AARS, AARS2, MT-TG, MT-TI, MT-TH, MT-TL1

Compounds for genes affiliated with Mitochondrial Cardiomyopathy

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Mitochondrial Cardiomyopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rrna449.5MT-ATP8, CS
2l-alanine28 59 11 2412.4AARS, AARS2
3rotenone449.1HMOX1, CS
4nadh44 11 2410.5HMOX1, MT-ATP8, CS

GO Terms for genes affiliated with Mitochondrial Cardiomyopathy

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Sources:
16Gene Ontology
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Biological processes related to Mitochondrial Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:0064189.4AARS, AARS2

Molecular functions related to Mitochondrial Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA bindingGO:0000499.4AARS, AARS2
2alanine-tRNA ligase activityGO:0048139.1AARS, AARS2

Products for genes affiliated with Mitochondrial Cardiomyopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitochondrial Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet