MCID: MTC015
MIFTS: 31

Mitochondrial Dna-Associated Leigh Syndrome and Narp malady

Genetic diseases (common) category
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Summaries for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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MalaCards based summary: Mitochondrial Dna-Associated Leigh Syndrome and Narp, also known as mtdna-associated leigh syndromenarp, is related to leigh syndrome due to mitochondrial complex i deficiency and mitochondrial disorders. An important gene associated with Mitochondrial Dna-Associated Leigh Syndrome and Narp is MT-TV (mitochondrially encoded tRNA valine), and among its related pathways are tRNA Aminoacylation and Alzheimer's disease. The compounds solium and rotenone have been mentioned in the context of this disorder.

GeneReviews summary for narp

Aliases & Classifications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Mitochondrial Dna-Associated Leigh Syndrome and Narp, Aliases & Descriptions:

Name: Mitochondrial Dna-Associated Leigh Syndrome and Narp 19 20 22
 
Mtdna-Associated Leigh Syndromenarp 19


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Graphical network of diseases related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:



Diseases related to mitochondrial dna-associated leigh syndrome and narp

Symptoms for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drugs & Therapeutics for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drug clinical trials:

Search ClinicalTrials for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search NIH Clinical Center for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Genetic Tests for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Genetic tests related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

id Genetic test Affiliating Genes
1 Mitochondrial Dna-Associated Leigh Syndrome and Narp20 22 MT-ATP6, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TL1 (show all 12)

MT-TV, MT-TW

Anatomical Context for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Animal Models for Mitochondrial Dna-Associated Leigh Syndrome and Narp or affiliated genes

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Publications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Articles related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

idTitleAuthorsYear
1
Mitochondrial DNA-Associated Leigh Syndrome and NARP (20301352)
1993

Variations for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Expression for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Expression patterns in normal tissues for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search GEO for disease gene expression data for Mitochondrial Dna-Associated Leigh Syndrome and Narp.

Pathways for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Compounds for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1solium4410.0MT-ND1, MT-ATP6
2rotenone449.8MT-ND6, MT-ND1
3pyruvate449.3MT-ND3, MT-ND1, MT-ND4
4methionine449.3MT-ND5, MT-ND2, MT-ND6, MT-ND1
5valine449.0MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND5
6threonine449.0MT-ND4, MT-ND1, MT-ND2, MT-ND3, MT-ND5
7alanine448.9MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
8atp44 289.8MT-ND4, MT-ND1, MT-CO3, MT-ATP6, MT-ND5
9Ubiquinol 8248.3MT-ND4, NDUFS7, MT-ND5, MT-ND3, MT-ND2, MT-ND6
10Sulfide247.9MT-ND4, MT-ND1, MT-ND6, MT-ND2, NDUFA12, NDUFA2
11Ubiquinone Q2247.9NDUFA2, NDUFA12, MT-ND2, MT-ND6, MT-ND1, MT-ND4
12QH2247.9MT-ND4, NDUFS7, NDUFA2, NDUFA12, MT-ND2, MT-ND6
13iron44 248.4MT-ND4, MT-ND1, MT-ND6, MT-ND2, BCS1L, NDUFA12
14FAD247.3FOXRED1, MT-ND4, MT-ND1, MT-ND6, MT-ND2, NDUFA12
15Ubiquinone Q1247.3MT-ND3, MT-ND2, MT-ND6, MT-ND1, MT-ND4, MT-ND5
16nad28 248.2MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
17nadh44 24 118.8NDUFS7, NDUFA2, NDUFA12, MT-ND5, MT-ATP6, MT-ND3

GO Terms for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Cellular components related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:0057478.6NDUFS7, NDUFA2, NDUFA12
2mitochondrial inner membraneGO:0057438.1NDUFS7, NDUFA2, NDUFA12, COX15

Biological processes related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial electron transport, NADH to ubiquinoneGO:0061209.4NDUFS7, NDUFA2
2mitochondrial respiratory chain complex I assemblyGO:0329819.3BCS1L, NDUFS7
3respiratory electron transport chainGO:0229048.9NDUFS7, NDUFA2, NDUFA12
4cellular metabolic processGO:0442378.9NDUFS7, NDUFA2, NDUFA12
5respiratory gaseous exchangeGO:0075858.8NDUFA12, COX15

Molecular functions related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADH dehydrogenase (ubiquinone) activityGO:0081378.9NDUFS7, NDUFA2, NDUFA12

Products for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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  • Antibodies
  • Proteins
  • Lysates

Sources for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet