MCID: MTC015
MIFTS: 26

Mitochondrial Dna-Associated Leigh Syndrome and Narp malady

Genetic diseases (common) category

Aliases & Classifications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Aliases & Descriptions for Mitochondrial Dna-Associated Leigh Syndrome and Narp:

Name: Mitochondrial Dna-Associated Leigh Syndrome and Narp 19 20 22
 
Mtdna-Associated Leigh Syndromenarp 19


Classifications:



Summaries for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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MalaCards based summary: Mitochondrial Dna-Associated Leigh Syndrome and Narp, also known as mtdna-associated leigh syndromenarp, is related to leigh syndrome and mitochondrial disorders. An important gene associated with Mitochondrial Dna-Associated Leigh Syndrome and Narp is MT-TV (mitochondrially encoded tRNA valine), and among its related pathways are tRNA Aminoacylation and Alzheimer's disease. The compounds solium and rotenone have been mentioned in the context of this disorder.

GeneReviews summary for narp

Related Diseases for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Graphical network of diseases related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:



Diseases related to mitochondrial dna-associated leigh syndrome and narp

Symptoms for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drugs & Therapeutics for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drug clinical trials:

Search ClinicalTrials for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search NIH Clinical Center for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Genetic Tests for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Genetic tests related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

id Genetic test Affiliating Genes
1 Mitochondrial Dna-Associated Leigh Syndrome and Narp20 22 MT-ATP6, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TL1 (show all 12)

MT-TV, MT-TW

Anatomical Context for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Animal Models for Mitochondrial Dna-Associated Leigh Syndrome and Narp or affiliated genes

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Publications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Articles related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

idTitleAuthorsYear
1
Mitochondrial DNA-Associated Leigh Syndrome and NARP (20301352)
1993

Variations for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Expression for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Search GEO for disease gene expression data for Mitochondrial Dna-Associated Leigh Syndrome and Narp.

Pathways for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Compounds for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1solium4410.0MT-ND1, MT-ATP6
2rotenone449.8MT-ND1, MT-ND6
3pyruvate449.3MT-ND3, MT-ND1, MT-ND4
4methionine449.3MT-ND1, MT-ND2, MT-ND6, MT-ND5
5valine449.0MT-ND4, MT-ND5, MT-ND2, MT-ND6, MT-ND1
6threonine449.0MT-ND1, MT-ND2, MT-ND5, MT-ND3, MT-ND4
7alanine448.9MT-ND5, MT-ND1, MT-ND3, MT-ND2, MT-ND6
8atp44 289.8MT-ND4, MT-ND1, MT-CO3, MT-ATP6, MT-ND5
9Ubiquinol 8248.3MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
10Sulfide247.9NDUFS7, NDUFA2, NDUFA12, MT-ND2, MT-ND4, MT-ND1
11Ubiquinone Q2247.9MT-ND6, NDUFS7, MT-ND1, MT-ND2, NDUFA12, NDUFA2
12QH2247.9NDUFA2, NDUFS7, MT-ND4, MT-ND1, MT-ND6, MT-ND2
13iron44 248.4NDUFS7, NDUFA2, NDUFA12, BCS1L, MT-ND2, MT-ND6
14FAD247.3FOXRED1, MT-ND4, MT-ND6, MT-ND2, NDUFA12, NDUFA2
15Ubiquinone Q1247.3MT-ND5, NDUFS7, NDUFA12, NDUFA2, MT-ND4, MT-ND1
16nad28 248.2MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
17nadh44 24 118.8NDUFA12, NDUFA2, NDUFS7, MT-ND5, MT-ND4, MT-CO3

GO Terms for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Cellular components related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:00057478.6NDUFS7, NDUFA2, NDUFA12
2mitochondrial inner membraneGO:00057438.1NDUFS7, NDUFA2, NDUFA12, COX15

Biological processes related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial electron transport, NADH to ubiquinoneGO:00061209.4NDUFS7, NDUFA2
2mitochondrial respiratory chain complex I assemblyGO:00329819.3BCS1L, NDUFS7
3respiratory electron transport chainGO:00229048.9NDUFS7, NDUFA2, NDUFA12
4cellular metabolic processGO:00442378.9NDUFS7, NDUFA2, NDUFA12
5respiratory gaseous exchangeGO:00075858.8NDUFA12, COX15

Molecular functions related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADH dehydrogenase (ubiquinone) activityGO:00081378.9NDUFS7, NDUFA2, NDUFA12

Sources for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet