MCID: MTC015
MIFTS: 31

Mitochondrial Dna-Associated Leigh Syndrome and Narp malady

Genetic diseases (common) category

Summaries for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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20GeneReviews, 34MalaCards
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MalaCards: Mitochondrial Dna-Associated Leigh Syndrome and Narp, also known as mtdna-associated leigh syndromenarp, is related to leigh syndrome due to mitochondrial complex i deficiency and mitochondrial disorders. An important gene associated with Mitochondrial Dna-Associated Leigh Syndrome and Narp is MT-TV (mitochondrially encoded tRNA valine), and among its related pathways are tRNA Aminoacylation and Alzheimer's disease. The compounds solium and rotenone have been mentioned in the context of this disorder.

GeneReviews summary for narp

Aliases & Classifications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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20GeneReviews, 21GeneTests, 23GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

mitochondrial dna-associated leigh syndrome and narp 20 21 23
mtdna-associated leigh syndromenarp 20


Related Diseases for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:



Diseases related to mitochondrial dna-associated leigh syndrome and narp

Symptoms for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drugs & Therapeutics for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Genetic Tests for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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21GeneTests, 23GTR
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Genetic tests related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

id Genetic test Affiliating Genes
1 Mitochondrial Dna-Associated Leigh Syndrome and Narp21 23 MT-ATP6, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TL1 (show all 12)

MT-TV, MT-TW

Anatomical Context for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Animal Models for Mitochondrial Dna-Associated Leigh Syndrome and Narp or affiliated genes

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Publications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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53PubMed
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Articles related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

idTitleAuthorsYear
1
Mitochondrial DNA-Associated Leigh Syndrome and NARP (20301352)
1993

Variations for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Expression for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Pathways for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1solium4610.0MT-ND1, MT-ATP6
2rotenone469.8MT-ND6, MT-ND1
3pyruvate469.3MT-ND3, MT-ND1, MT-ND4
4methionine469.3MT-ND5, MT-ND2, MT-ND6, MT-ND1
5valine469.0MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND5
6threonine469.0MT-ND4, MT-ND1, MT-ND2, MT-ND3, MT-ND5
7alanine468.9MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
8atp46 309.8MT-ND4, MT-ND1, MT-CO3, MT-ATP6, MT-ND5
9Ubiquinol 8258.3MT-ND4, NDUFS7, MT-ND5, MT-ND3, MT-ND2, MT-ND6
10Sulfide257.9MT-ND4, MT-ND1, MT-ND6, MT-ND2, NDUFA12, NDUFA2
11Ubiquinone Q2257.9NDUFA2, NDUFA12, MT-ND2, MT-ND6, MT-ND1, MT-ND4
12QH2257.9MT-ND4, NDUFS7, NDUFA2, NDUFA12, MT-ND2, MT-ND6
13iron46 258.4MT-ND4, MT-ND1, MT-ND6, MT-ND2, BCS1L, NDUFA12
14FAD257.3FOXRED1, MT-ND4, MT-ND1, MT-ND6, MT-ND2, NDUFA12
15Ubiquinone Q1257.3MT-ND3, MT-ND2, MT-ND6, MT-ND1, MT-ND4, MT-ND5
16nad30 258.2MT-ND4, MT-ND1, MT-ND6, MT-ND2, MT-ND3, MT-ND5
17nadh46 25 128.8NDUFS7, NDUFA2, NDUFA12, MT-ND5, MT-ATP6, MT-ND3

GO Terms for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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17Gene Ontology
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Cellular components related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:0057478.6NDUFS7, NDUFA2, NDUFA12
2mitochondrial inner membraneGO:0057438.1NDUFS7, NDUFA2, NDUFA12, COX15

Biological processes related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial electron transport, NADH to ubiquinoneGO:0061209.4NDUFS7, NDUFA2
2mitochondrial respiratory chain complex I assemblyGO:0329819.3BCS1L, NDUFS7
3respiratory electron transport chainGO:0229048.9NDUFS7, NDUFA2, NDUFA12
4cellular metabolic processGO:0442378.9NDUFS7, NDUFA2, NDUFA12
5respiratory gaseous exchangeGO:0075858.8NDUFA12, COX15

Molecular functions related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADH dehydrogenase (ubiquinone) activityGO:0081378.9NDUFS7, NDUFA2, NDUFA12

Products for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Sources for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet