MCID: MTC015
MIFTS: 28

Mitochondrial Dna-Associated Leigh Syndrome and Narp malady

Summaries for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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MalaCards: Mitochondrial Dna-Associated Leigh Syndrome and Narp, also known as mtdna-associated leigh syndromenarp, is related to leukodystrophy and opa3-related 3-methylglutaconic aciduria. An important gene associated with Mitochondrial Dna-Associated Leigh Syndrome and Narp is MT-TV (mitochondrially encoded tRNA valine), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and tRNA Aminoacylation. The compounds solium and N-Formylmethionine have been mentioned in the context of this disorder.

GeneReviews summary for narp

Aliases & Classifications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Aliases & Descriptions:

mitochondrial dna-associated leigh syndrome and narp 19 20 22
mtdna-associated leigh syndromenarp 19


Related Diseases for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Graphical network of diseases related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:



Diseases related to mitochondrial dna-associated leigh syndrome and narp

Clinical Features for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Drugs & Therapeutics for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Genetic tests related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

id Genetic test Affiliating Genes
1 Mitochondrial Dna-Associated Leigh Syndrome and Narp20 22 MT-ATP6, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TL1 (show all 12)

MT-TV, MT-TW

Anatomical Context for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Animal Models for Mitochondrial Dna-Associated Leigh Syndrome and Narp or affiliated genes

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Publications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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50PubMed
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Articles related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

idTitleAuthorsYear
1
Mitochondrial DNA-Associated Leigh Syndrome and NARP (20301352)
1993

Genetic Variations for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Expression for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Pathways for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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49PharmGKB, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1solium4410.2MT-ND1, MT-ATP6
2N-Formylmethionine1110.0MT-CO3, MT-ND1
3pyruvate449.7MT-ND1, MT-ND4, MT-ND3, SURF1
4methionine449.7MT-ND6, MT-ND1, MT-ND5, MT-ND2
5valine449.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
6alanine449.5MT-ND2, MT-ND3, MT-ND5, MT-ND1, MT-ND6
7threonine449.2MT-ND1, MT-ND4, MT-ND5, MT-ND3, MT-ND2
8iron44 249.6NDUFS3, NDUFS8, NDUFA2, NDUFS7, MT-ND6, MT-ND1
9nad28 249.5NDUFS7, NDUFA2, NDUFS8, NDUFS3, MT-ND6, MT-ND1
10nadh44 11 2410.2MT-ND2, NDUFS3, NDUFS8, NDUFA2, NDUFS7, MT-ND6

GO Terms for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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16Gene Ontology
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Cellular components related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:0057479.1NDUFS7, NDUFA2, NDUFS8, NDUFS3
2mitochondrial inner membraneGO:0057439.1NDUFS7, NDUFAF6, NDUFA2, NDUFS8, NDUFS3

Biological processes related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular metabolic processGO:0442379.4NDUFS7, NDUFA2, NDUFS8, NDUFS3
2mitochondrial respiratory chain complex I assemblyGO:0329819.4BCS1L, NDUFS7, NDUFAF6, NDUFS8
3mitochondrial electron transport, NADH to ubiquinoneGO:0061209.3NDUFS3, NDUFS8, NDUFA2, NDUFS7
4respiratory electron transport chainGO:0229049.1NDUFS3, NDUFS8, NDUFA2, NDUFS7

Molecular functions related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
14 iron, 4 sulfur cluster bindingGO:0515399.9NDUFS7, NDUFS8
2NADH dehydrogenase activityGO:0039549.4NDUFS7, NDUFS8, NDUFS3
3NADH dehydrogenase (ubiquinone) activityGO:0081379.3NDUFS7, NDUFA2, NDUFS8, NDUFS3

Products for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

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Sources for Mitochondrial Dna-Associated Leigh Syndrome and Narp

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet