MCID: MTC015
MIFTS: 24

Mitochondrial Dna-Associated Leigh Syndrome and Narp malady

Summaries for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
19GeneReviews, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Mitochondrial Dna-Associated Leigh Syndrome and Narp, also known as mtdna-associated leigh syndromenarp, is related to n syndrome and leukodystrophy. An important gene associated with Mitochondrial Dna-Associated Leigh Syndrome and Narp is MT-TV (mitochondrially encoded tRNA valine), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and tRNA Aminoacylation. The compounds solium and N-Formylmethionine have been mentioned in the context of this disorder.

GeneReviews summary for narp

Aliases & Classifications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
19GeneReviews, 20GeneTests, 22GTR
See all sources

Aliases & Descriptions:

mitochondrial dna-associated leigh syndrome and narp 19 20 22
mtdna-associated leigh syndromenarp 19


Related Diseases for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:



Diseases related to mitochondrial dna-associated leigh syndrome and narp

Clinical Features for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Drugs & Therapeutics for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Drug clinical trials:

Search ClinicalTrials for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search NIH Clinical Center for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search CenterWatch for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Genetic Tests for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Mitochondrial Dna-Associated Leigh Syndrome and Narp:

id Genetic test Affiliating Genes
1 Mitochondrial Dna-associated Leigh Syndrome And Narp20 22 MT-ATP6, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, MT-TK, MT-TL1 (show all 12)

MT-TV, MT-TW

Anatomical Context for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Animal Models for Mitochondrial Dna-Associated Leigh Syndrome and Narp or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Genetic Variations for Mitochondrial Dna-Associated Leigh Syndrome and Narp

Expression for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Search GEO for disease gene expression data for Mitochondrial Dna-Associated Leigh Syndrome and Narp.

Pathways for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
50PharmGKB, 54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1solium4510.2MT-ND1, MT-ATP6
2N-Formylmethionine1110.0MT-CO3, MT-ND1
3pyruvate459.7MT-ND1, MT-ND4, MT-ND3, SURF1
4methionine459.7MT-ND6, MT-ND1, MT-ND5, MT-ND2
5valine459.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
6alanine459.5MT-ND2, MT-ND3, MT-ND5, MT-ND1, MT-ND6
7threonine459.2MT-ND1, MT-ND4, MT-ND5, MT-ND3, MT-ND2
8iron45 249.6NDUFS3, NDUFS8, NDUFA2, NDUFS7, MT-ND6, MT-ND1
9nad29 249.5NDUFS7, NDUFA2, NDUFS8, NDUFS3, MT-ND6, MT-ND1
10nadh45 11 2410.2MT-ND2, NDUFS3, NDUFS8, NDUFA2, NDUFS7, MT-ND6

GO Terms for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

Sources:
16Gene Ontology
See all sources

Cellular components related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:0057479.1NDUFS7, NDUFA2, NDUFS8, NDUFS3
2mitochondrial inner membraneGO:0057439.1NDUFS7, NDUFAF6, NDUFA2, NDUFS8, NDUFS3

Biological processes related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular metabolic processGO:0442379.4NDUFS7, NDUFA2, NDUFS8, NDUFS3
2mitochondrial respiratory chain complex I assemblyGO:0329819.4BCS1L, NDUFS7, NDUFAF6, NDUFS8
3mitochondrial electron transport, NADH to ubiquinoneGO:0061209.3NDUFS3, NDUFS8, NDUFA2, NDUFS7
4respiratory electron transport chainGO:0229049.1NDUFS3, NDUFS8, NDUFA2, NDUFS7

Molecular functions related to Mitochondrial Dna-Associated Leigh Syndrome and Narp according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
14 iron, 4 sulfur cluster bindingGO:0515399.9NDUFS7, NDUFS8
2NADH dehydrogenase activityGO:0039549.4NDUFS7, NDUFS8, NDUFS3
3NADH dehydrogenase (ubiquinone) activityGO:0081379.3NDUFS7, NDUFA2, NDUFS8, NDUFS3

Products for genes affiliated with Mitochondrial Dna-Associated Leigh Syndrome and Narp

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitochondrial Dna-Associated Leigh Syndrome and Narp

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet