MELAS
MCID: MTC023
MIFTS: 24

Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes (MELAS) malady

Summaries for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (melas) affects many parts of the body, particularly the brain and nervous system (encephalo-) and muscles (myopathy). symptoms typically begin in childhood and may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. most affected individuals experience stroke-like episodes beginning before age 40. people with melas can also have a buildup of lactic acid in their bodies that can lead to vomiting, abdominal pain, fatigue, muscle weakness, and difficulty breathing. the genes associated with melas are located in mitochondrial dna and therefore follow a maternal inheritance pattern (also called mitochondrial inheritance). melas can be inherited from the mother only, because only females pass mitochondrial dna to their children. in some cases, melas results from a new mutation that was not inherited from a person's mother. last updated: 12/3/2013

MalaCards: Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes, also known as melas syndrome, is related to melas syndrome and parkinson's disease. An important gene associated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes is MT-TK (mitochondrially encoded tRNA lysine), and among its related pathways is tRNA Aminoacylation. The compounds valine and nad have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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43NIH Rare Diseases, 21Genetics Home Reference, 61UMLS
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Aliases & Descriptions:

mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 43
melas syndrome 43 21 61
melas 43 21
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 21
mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes 21
myopathy, mitochondrial-encephalopathy-lactic acidosis-stroke 21
mitochondrial myopathy, lactic acidosis, stroke-like episode 21


Related Diseases for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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17GeneCards, 18GeneDecks
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Diseases related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1melas syndrome36.5MT-TL1, MT-ND5
2parkinson's disease35.9MT-ND5, MT-ND1, GHRH
3merrf syndrome35.4MT-ND5, MT-TK
4leber hereditary optic neuropathy34.8MT-ND1, MT-ND6, MT-ND5, MT-ND4
5mitochondrial complex i deficiency34.8MT-ND6, MT-ND5
6blindness34.8MT-ND4
7leigh disease13.3MT-ND5, MT-ND4
8diabetes mellitus13.3MT-ND1, GH1
9lactic acidosis13.3MT-ND4, MT-ND1, GHRH, MT-ND5
10optic nerve disease13.3MT-ND4, MT-ND6
11mitochondrial dna-associated leigh syndrome and narp13.3MT-ND4, MT-TK, MT-TL1, MT-ND5, MT-ND1, MT-ND6
12mitochondrial disorders13.3MT-ND4, MT-ND5
13opa3-related 3-methylglutaconic aciduria13.3MT-ND4
14leber hereditary optic neuropathy with dystonia13.3MT-ND4, MT-ND6
15encephalomyopathy11.3
16acanthocytosis10.6
17growth hormone deficiency10.6
18vitiligo10.6
193-m syndrome10.6
20herpes simplex encephalitis10.6
21mitochondrial cardiomyopathy10.6
22ileus10.6
23n syndrome10.5
24merrf/melas overlap syndrome10.4
25sensorineural hearing loss10.1
26paralytic ileus10.0
27status epilepticus10.0
28kearns-sayre syndrome10.0
29young syndrome10.0
30say syndrome10.0
31melas, mt-nd6-related10.0
32melas, mt-nd1-related10.0
33melas, mt-tk-related10.0
34melas, mt-ts1-related10.0
35melas, mt-nd5-related10.0
36melas, mt-tl1-related10.0
37melas, mt-ts2-related10.0
38melas, mt-tf-related10.0
39melas, mt-tq-related10.0
40melas, mt-th-related10.0
41fibrous dysplasia10.0GH1
42pituitary hypoplasia10.0GHRH
43vipoma10.0GHRH, GH1
44adrenal gland hyperfunction10.0GH1, GHRH
45glucagonoma10.0GHRH, GH1
46cushing's syndrome10.0GHRH, GH1
47hyperprolactinemia10.0GHRH, GH1
48hypopituitarism10.0GH1, GHRH
49moyamoya disease9.9
50wolff-parkinson-white syndrome9.9

Graphical network of the top 20 diseases related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes:



Diseases related to mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes

Clinical Features for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

Drugs & Therapeutics for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

Anatomical Context for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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MalaCards organs/tissues related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes:

33
Brain

Animal Models for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like... or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

Genetic Variations for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

Expression for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes

Search GEO for disease gene expression data for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes.

Pathways for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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54Reactome, 30KEGG
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Pathways related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5MT-TK, MT-TL1

Compounds for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1valine4510.8
2nad29 2411.8
3nadh45 11 2412.8
4methionine4510.7
5rotenone4510.7
6isoleucine4510.5
7iron45 2411.2
8glucose4510.0GHRH
9alanine459.9GH1
10ghrp459.4GH1, GHRH
11hexarelin45 2910.4GHRH, GH1
12pyridostigmine45 1110.4GHRH, GH1
13pegvisomant45 1110.4GH1, GHRH
14acipimox45 2910.4GH1, GHRH
15lanreotide45 2910.4GH1, GHRH
16pirenzepine45 29 1111.3GHRH, GH1
17naltrexone45 50 29 1112.3GH1, GHRH
18sumatriptan45 29 60 50 11 2414.3GH1, GHRH
19serine459.3GHRH, GH1
20salbutamol45 50 29 11 2413.3GH1, GHRH
21bromocriptine29 45 1111.3GH1, GHRH
22naloxone45 50 29 1112.2GHRH, GH1
23clonidine45 29 1111.2GH1, GHRH
24octreotide45 60 29 1112.0GHRH, GH1
25opiate459.0GH1, GHRH
26atropine45 29 1110.9GH1, GHRH

GO Terms for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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16Gene Ontology
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Biological processes related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:0400189.0GH1, GHRH
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435688.7GH1, GHRH

Products for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet