MELAS
MCID: MTC023
MIFTS: 25

Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes (MELAS) malady

Summaries for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (melas) affects many parts of the body, particularly the brain and nervous system (encephalo-) and muscles (myopathy). symptoms typically begin in childhood and may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. most affected individuals experience stroke-like episodes beginning before age 40. people with melas can also have a buildup of lactic acid in their bodies that can lead to vomiting, abdominal pain, fatigue, muscle weakness, and difficulty breathing. the genes associated with melas are located in mitochondrial dna and therefore follow a maternal inheritance pattern (also called mitochondrial inheritance). melas can be inherited from the mother only, because only females pass mitochondrial dna to their children. in some cases, melas results from a new mutation that was not inherited from a person's mother. last updated: 12/3/2013

MalaCards: Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes, also known as melas syndrome, is related to lactic acidosis and melas syndrome. An important gene associated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes is MT-TK (mitochondrially encoded tRNA lysine), and among its related pathways is tRNA Aminoacylation. The compounds valine and nad have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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42NIH Rare Diseases, 21Genetics Home Reference, 60UMLS
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Aliases & Descriptions:

mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 42
melas syndrome 42 21 60
melas 42 21
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 21
mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes 21
myopathy, mitochondrial-encephalopathy-lactic acidosis-stroke 21
mitochondrial myopathy, lactic acidosis, stroke-like episode 21


Related Diseases for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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Diseases related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1lactic acidosis36.8MT-ND4, MT-ND1, GHRH, MT-ND5
2melas syndrome36.5MT-TL1, MT-ND5
3diabetes mellitus36.0MT-ND1, GH1
4parkinson's disease35.8MT-ND5, MT-ND1, GHRH
5merrf syndrome35.3MT-ND5, MT-TK
6mitochondrial disorders35.1MT-ND4, MT-ND5
7leber hereditary optic neuropathy34.7MT-ND1, MT-ND6, MT-ND5, MT-ND4
8leigh disease13.3MT-ND5, MT-ND4
9optic nerve disease13.3MT-ND4, MT-ND6
10mitochondrial dna-associated leigh syndrome and narp13.3MT-ND4, MT-TK, MT-TL1, MT-ND5, MT-ND1, MT-ND6
11opa3-related 3-methylglutaconic aciduria13.3MT-ND4
12mitochondrial complex i deficiency13.3MT-ND6, MT-ND5
13leber hereditary optic neuropathy with dystonia13.3MT-ND4, MT-ND6
14blindness13.3MT-ND4
15mitochondrial encephalomyopathy11.2
16pancreatitis10.7
17diabetic ketoacidosis10.6
18intestinal pseudo-obstruction10.6
19vitiligo10.6
20encephalitis10.6
21herpes simplex10.6
22intestinal obstruction10.6
23image syndrome10.6
24myopathy10.5
25cerebritis10.2
26status epilepticus10.1
27sensorineural hearing loss10.1
28hyperthyroidism10.1
29thyroiditis10.1
30merrf/melas overlap syndrome10.1
31paralytic ileus10.0
32choroiditis10.0
33kearns-sayre syndrome10.0
34melanoma10.0
35encephalomyopathy10.0
36melas, mt-nd6-related10.0
37melas, mt-nd1-related10.0
38melas, mt-tk-related10.0
39melas, mt-ts1-related10.0
40melas, mt-nd5-related10.0
41melas, mt-tl1-related10.0
42melas, mt-ts2-related10.0
43melas, mt-tf-related10.0
44melas, mt-tq-related10.0
45melas, mt-th-related10.0
46fibrous dysplasia10.0GH1
47moyamoya disease10.0
48meningoencephalitis10.0
49neuronitis10.0
50cortical blindness10.0

Graphical network of the top 20 diseases related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes:



Diseases related to mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes

Clinical Features for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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Drugs & Therapeutics for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Anatomical Context for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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MalaCards organs/tissues related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes:

32
Brain

Animal Models for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like... or affiliated genes

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Genetic Variations for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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Expression for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes

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Pathways for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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53Reactome, 29KEGG
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Pathways related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5MT-TK, MT-TL1

Compounds for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1valine4410.8
2nad28 2411.8
3nadh44 11 2412.8
4methionine4410.7
5rotenone4410.7
6isoleucine4410.5
7iron44 2411.2
8glucose4410.0GHRH
9alanine449.9GH1
10ghrp449.4GH1, GHRH
11pyridostigmine44 1110.4GHRH, GH1
12hexarelin44 2810.4GHRH, GH1
13pegvisomant44 1110.4GHRH, GH1
14acipimox44 2810.4GHRH, GH1
15lanreotide44 2810.4GHRH, GH1
16pirenzepine44 28 1111.3GH1, GHRH
17naltrexone44 49 28 1112.3GH1, GHRH
18sumatriptan44 28 59 49 11 2414.3GH1, GHRH
19serine449.3GHRH, GH1
20salbutamol44 49 28 11 2413.3GHRH, GH1
21bromocriptine28 44 1111.3GHRH, GH1
22naloxone44 49 28 1112.2GH1, GHRH
23clonidine44 28 1111.2GHRH, GH1
24octreotide44 59 28 1112.0GHRH, GH1
25opiate449.0GHRH, GH1
26atropine44 28 1110.9GHRH, GH1

GO Terms for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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Biological processes related to Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:0400189.0GH1, GHRH
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435688.7GH1, GHRH

Products for genes affiliated with Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like...

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
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34MeSH
35MESH via Orphanet
36MGI
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40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet