MCID: MTR012
MIFTS: 60

Mitral Valve Disease malady

Cardiovascular diseases category

Summaries for Mitral Valve Disease

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MalaCards based summary: Mitral Valve Disease, also known as rheumatic mitral valve incompetence, is related to atrial fibrillation and congestive heart failure. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are S1P3 pathway and amb2 Integrin signaling. The compounds aliskiren and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Mitral Valve Disease

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 12DISEASES, 29ICD9CM, 57SNOMED-CT, 40NCIt, 27ICD10
See all sources

Mitral Valve Disease, Aliases & Descriptions:

Name: Mitral Valve Disease 10 45
Rheumatic Mitral Valve Incompetence 10 12 62
Rheumatic Mitral Valve Regurgitation 10 62
Rheumatic Disease of Mitral Valve 10 62
Chronic Rheumatic Mitral Valve 10 62
Rheumatic Mitral Valve Changes 10
 
Rheumatic Mitral Insufficiency 10
Rheumatic Mitral Regurgitation 62
Diseases of Mitral Valve 62
Disease of Mitral Valve 10
Mitral Rh Valve Dis. 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1atrial fibrillation31.5AGTR1, NPPA, ACE, SELP
2congestive heart failure30.9ACE, NPPA, AGT, AGTR1
3pulmonary hypertension30.9AGT, NPPA, NOS3, TPH1
4mitral valve stenosis30.6NPPA, SELP
5coronary artery disease30.5SELP, ACE, NOS3, AGT, AGTR1
6orthostatic intolerance30.2AGTR1
7arteriosclerosis30.2NOS3
8nephrotic syndrome30.1AGT, NPPA, ACE
9ischemia30.1AGT, NOS3, AKT1, SELP, TGFB2
10artery disease10.4
11marfan syndrome10.3
12endocarditis10.3
13aneurysm10.3
14endotheliitis10.3
15muscle hypertrophy10.3
16dilated cardiomyopathy10.3
17dysphagia10.3
18blindness10.3
19systemic lupus erythematosus10.1
20migraine10.1
21mucopolysaccharidosis vii10.1
22end stage renal failure10.1
23ischemic heart disease10.1
24splenic abscess10.1
25polyarteritis nodosa10.1
26hyperlucent lung10.1
27pulmonary edema10.1
28cerebritis10.1
29thoracic aortic aneurysm10.1
30aortic aneurysm10.1
31infective endocarditis10.1
32intracranial aneurysm10.1
33lupus erythematosus10.1
34mucopolysaccharidosis10.1
35respiratory failure10.1
36ventricular septal defect10.1
37aortic coarctation10.1
38cor triatriatum10.1
39pectus carinatum10.1
40syncope10.1
41atrial septal aneurysm10.1
42sick sinus syndrome10.1NPPA
43hepatorenal syndrome10.1NPPA
44gitelman syndrome10.1AGT
45proliferative glomerulonephritis10.1SELP
46cor pulmonale10.0AGTR1, NPPA
47renal tubular dysgenesis10.0AGT, AGTR1
48conn's syndrome10.0NPPA, AGTR1
49aortic valve disease 210.0AGT, NPPA
50vesicoureteral reflux10.0AGTR1, AGT

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Symptoms for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

33
Heart, Lung, Endothelial, Brain, Smooth muscle, Testes, Kidney, Skin

Animal Models for Mitral Valve Disease or affiliated genes

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Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Development of atrial fibrillation in patients with rheumatic mitral valve disease in sinus rhythm. (25665684)
2015
2
Systolic cardiac function assessment by feature tracking echocardiography in dogs with myxomatous mitral valve disease. (25833040)
2015
3
Left atrial rupture secondary to myxomatous mitral valve disease in 11 dogs. (25251426)
2014
4
Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation. (25115553)
2014
5
Echocardiography in mitral valve disease. Preface. (23743080)
2013
6
The role of exercise echocardiography in the management of mitral valve disease. (23959848)
2013
7
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
8
Heritability of premature mitral valve disease in Cavalier King Charles spaniels. (20347358)
2011
9
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
10
Molecular changes in fibrillar collagen in myxomatous mitral valve disease. (19632135)
2010
11
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography. (21143934)
2010
12
Functional tricuspid regurgitation in mitral valve disease: epidemiology and prognostic implications. (20813320)
2010
13
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
14
Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. (21036114)
2010
15
Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs. (19324577)
2010
16
Acquired atrial septal defects secondary to rupture of the atrial septum in dogs with degenerative mitral valve disease. (20584637)
2010
17
Percutaneous surgery for mitral valve disease. (19875371)
2009
18
Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease. (19143935)
2009
19
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
20
Principles of reconstructive surgery in degenerative mitral valve disease. (17870003)
2007
21
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
22
Giant left atrium secondary to rheumatic mitral valve disease. (16849894)
2006
23
Surgical treatment of atrial fibrillation through isolation of the left atrial posterior wall in patients with chronic rheumatic mitral valve disease. A randomized study with control group. (15375469)
2004
24
Tissue Doppler properties of the left atrial appendage in patients with mitral valve disease. (15104544)
2004
25
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
26
The Quattro valve in rheumatic mitral valve disease: four-year follow up. (14658818)
2003
27
Location, size, and morphologic characteristics of left atrial thrombi as assessed by transesophageal echocardiography in relation to systemic embolism in patients with rheumatic mitral valve disease. (12633822)
2003
28
Encircling isolation of pulmonary vein orifice for elimination of persistent atrial fibrillation associated with mitral valve disease. (12974929)
2003
29
Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease. (12056726)
2002
30
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
31
Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. (11420162)
2001
32
Surgical repair of the prolapsing anterior leaflet in degenerative mitral valve disease. (10678378)
2000
33
Surgery for mitral valve disease in the pediatric age group. (10384192)
1999
34
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
35
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
36
Repair of chordae tendineae for rheumatic mitral valve disease. A twenty-year experience. (8551768)
1996
37
Left atrial performance indices in chronic mitral valve disease. (8564003)
1995
38
The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. (8043061)
1994
39
Combined warfarin and antiplatelet therapy after St. Jude Medical valve replacement for mitral valve disease. (8113551)
1994
40
Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease. (8174568)
1994
41
Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. (15636941)
1994
42
Significance of left atrial spontaneous echo contrast in rheumatic mitral valve disease as a predictor of systemic arterial embolization: a transesophageal echocardiographic study. (8154427)
1994
43
Diagnosis of left atrial thrombi in mitral valve disease by coronary arteriography. (1699665)
1990
44
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
45
Echocardiography in mitral valve disease: a review. (3916435)
1985
46
Mitral valve disease and dysphagia. (6241564)
1984
47
Conservative surgery for mitral valve disease: clinical and echocardiographic analysis of results. (6612646)
1983
48
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
49
Pulmonary edema after ritodrine infusion for premature labor in a patient with mitral valve disease. (7211242)
1981
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.5AKT1, CXCR4
29.5SELP, AKT1
39.5SELP, TGFB2
49.4TGFB2, AKT1
59.3NOS3, AKT1
69.3NOS3, AKT1
7
Show member pathways
9.3NOS3, AKT1
8
Show member pathways
Angiogenesis38
9.3AKT1, NOS3
99.3AGT, NPPA, AKT1
10
Show member pathways
9.1NPPA, AKT1, TGFB2
11
Show member pathways
9.1TGFB2, AKT1, AGT
129.0AKT1, NOS3, NPPA
13
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0AKT1, NOS3, AGTR1
14
Show member pathways
8.9AKT1, CXCR4, NOS3
15
Show member pathways
8.8NOS3, AKT1, TGFB2
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.6ACE, AKT1, TGFB2
17
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.6AGTR1, NOS3, CXCR4, AKT1
18
Show member pathways
8.4TGFB2, AKT1, CXCR4, NOS3
19
Show member pathways
8.4NOS3, CXCR4, AKT1, TGFB2
20
Show member pathways
8.4NOS3, AKT1, SELP, TGFB2
21
Show member pathways
8.3AGTR1, AGT, NOS3, ACE
22
Show member pathways
8.3TGFB2, AKT1, CXCR4, AGT, AGTR1
23
Show member pathways
7.9TGFB2, AKT1, ACE, AGT, AGTR1

Compounds for genes affiliated with Mitral Valve Disease

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Compounds related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1aliskiren45 1310.3AGTR1, AGT, ACE
2cilazapril45 1310.3ACE, AGTR1, NPPA
3trandolapril45 1310.3ACE, NPPA, AGTR1
4saralasin459.2AGTR1, ACE, AGT
5eprosartan45 30 1311.2AGT, ACE, AGTR1
6pd12331945 3010.2ACE, AGTR1, AGT
7fosinopril45 1310.1AGTR1, NPPA, ACE
8olmesartan45 30 1311.1AGTR1, ACE, AGT
9benazepril45 51 1311.1AGT, AGTR1, ACE, NPPA
10lisinopril45 51 26 1312.0NPPA, ACE, AGT, AGTR1
11enalapril45 51 1311.0AGTR1, ACE, NPPA, AGT
12quinapril45 51 1311.0SELP, AGTR1, ACE, NPPA
13captopril45 61 51 30 1313.0AGT, NPPA, ACE, AGTR1
14isosorbide dinitrate45 51 1310.9ACE, NPPA, NOS3
15enalaprilat458.9AGT, ACE, NPPA
16valsartan45 61 30 1311.9AGT, SELP, ACE, AGTR1
17prostaglandin458.9TGFB2, CXCR4, AGT, AGTR1, NPPA
18sele458.8SELP, ACE, AGT
19sodium nitroprusside458.8NPPA, SELP, TPH1, AGTR1, NOS3
20carvedilol45 51 30 1311.8AGTR1, ACE, NOS3, NPPA
21l-nmma458.7AKT1, AGTR1, AGT, NPPA, NOS3
22phenylephrine45 30 26 1311.7NOS3, NPPA, AGT, AGTR1, AKT1
23simvastatin45 51 61 30 26 1313.5AGTR1, SELP, NOS3, AKT1, AGT
24fluvastatin45 51 30 1311.5AGTR1, NOS3, ACE, SELP
25n acetylcysteine458.5AGTR1, AGT, SELP, TGFB2, AKT1
26epinephrine45 26 1310.5AGTR1, NPPA, SELP, AKT1, CXCR4, AGT
27perindopril45 51 1310.5NPPA, NOS3, ACE, AGTR1, AGT
28amlodipine45 51 26 1311.5AGT, AGTR1, NPPA, NOS3, ACE
29ang ii458.4AGTR1, ACE, NOS3, AGT, NPPA
30dopamine45 30 26 1311.4TPH1, TGFB2, AKT1, NPPA, AGTR1, AGT
31cyclosporin a45 30 6110.4SELP, AGT, CXCR4, NPPA, TGFB2, AGTR1
32sb 20358045 619.4AGTR1, NOS3, CXCR4, AKT1, AGT
33nitroglycerin45 139.4NOS3, AGTR1, NPPA, ACE, SELP
34candesartan45 51 30 1311.3AGTR1, NOS3, ACE, SELP, AGT
35norepinephrine45 26 1310.3ACE, TPH1, AGTR1, SELP, NPPA, AGT
36pge2458.2TGFB2, AGT, NPPA, CXCR4, AKT1, SELP
37aspirin45 51 30 2611.1NOS3, ACE, CXCR4, SELP, AGTR1
38losartan45 51 30 1311.1AGT, SELP, AKT1, ACE, NPPA, AGTR1
39atorvastatin45 51 30 26 1312.1SELP, AKT1, ACE, NOS3, AGT
40genistein45 30 61 3 26 1313.0AGTR1, AKT1, SELP, AGT, NOS3, TGFB2
41pravastatin45 51 30 26 1311.9SELP, ACE, NOS3, AGTR1
42acetylcholine45 51 30 26 1311.9TPH1, AKT1, ACE, NOS3, AGTR1, AGT
43dexamethasone45 51 30 1310.8AGT, AGTR1, SELP, TGFB2, CXCR4, AKT1
44arginine457.6NOS3, AGTR1, AGT, TPH1, NPPA, SELP
45creatinine457.6AGT, NPPA, ACE, AKT1, TGFB2, SELP
46prostacyclin457.5SELP, AKT1, ACE, NOS3, NPPA, AGT
47estrogen457.4TPH1, TGFB2, SELP, AGTR1, NOS3, NPPA
48vegf457.4AGT, NPPA, NOS3, CXCR4, AKT1, SELP
49calcium45 51 26 139.8TGFB2, ACE, AGTR1, AGT, NPPA, NOS3
50nitric oxide45 26 138.8TGFB2, CXCR4, TPH1, AGTR1, AGT, NPPA

GO Terms for genes affiliated with Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5SELP, CXCR4, ACE
2extracellular spaceGO:00056157.9AGT, NPPA, ACE, SELP, TGFB2
3plasma membraneGO:00058867.3AGTR1, NOS3, ACE, CXCR4, AKT1, SELP

Biological processes related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:000203410.2AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:003386410.1AGTR1, AGT
3regulation of renal sodium excretionGO:003581310.1AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, AGTR1
5positive regulation of cholesterol esterificationGO:001087310.1AGT, AGTR1
6low-density lipoprotein particle remodelingGO:003437410.1AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:020003799.9AGT, AGTR1
9regulation of blood vessel sizeGO:00508809.8NOS3, NPPA
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8AGT, AGTR1
11positive regulation of inflammatory responseGO:00507299.8AGTR1, AGT
12nitric oxide mediated signal transductionGO:00072639.7AGT, NOS3
13response to fluid shear stressGO:00344059.7AKT1, NOS3
14regulation of renal output by angiotensinGO:00020199.7AGT, ACE
15regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.7AGTR1, ACE
16germ cell developmentGO:00072819.7CXCR4, AKT1
17cellular response to mechanical stimulusGO:00712609.7AGT, NPPA, AKT1
18positive regulation of cellular protein metabolic processGO:00322709.6AKT1, AGT, AGTR1
19regulation of vasodilationGO:00423129.6AGTR1, ACE
20nitric oxide biosynthetic processGO:00068099.6NOS3, AKT1
21negative regulation of cell growthGO:00303089.6AGT, NPPA, TGFB2
22angiotensin maturationGO:00020039.6AGT, ACE
23regulation of nitric-oxide synthase activityGO:00509999.6AKT1, NOS3
24nitric oxide metabolic processGO:00462099.5AKT1, NOS3
25positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5TGFB2, SELP, AGT
26response to hypoxiaGO:00016669.5NPPA, CXCR4, TGFB2
27calcium-mediated signalingGO:00197229.4AGTR1, CXCR4
28regulation of vasoconstrictionGO:00192299.3AGTR1, AGT, ACE
29response to heatGO:00094089.3NOS3, AKT1
30kidney developmentGO:00018229.3AGTR1, AGT, ACE
31G-protein coupled receptor signaling pathwayGO:00071869.2AKT1, CXCR4, AGT, AGTR1
32platelet activationGO:00301689.2AKT1, SELP, TGFB2
33regulation of blood pressureGO:00082179.1ACE, NOS3, NPPA
34inflammatory responseGO:00069549.0SELP, AKT1, CXCR4
35blood coagulationGO:00075968.7TGFB2, SELP, AKT1, NOS3
36blood vessel remodelingGO:00019748.5AGT, NOS3, ACE, TGFB2

Molecular functions related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:00317119.0AGTR1, ACE
2protein bindingGO:00055156.4SELP, AKT1, CXCR4, ACE, NOS3, AGT

Products for genes affiliated with Mitral Valve Disease

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Sources for Mitral Valve Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet