MCID: MTR012
MIFTS: 52

Mitral Valve Disease malady

Cardiovascular diseases category

Summaries for Mitral Valve Disease

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MalaCards based summary: Mitral Valve Disease, also known as rheumatic mitral valve incompetence, is related to atrial fibrillation and mitral valve stenosis. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are S1P3 pathway and amb2 Integrin signaling. The compounds aliskiren and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Mitral Valve Disease

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 11DISEASES, 27ICD9CM, 55SNOMED-CT, 38NCIt, 25ICD10
See all sources

Mitral Valve Disease, Aliases & Descriptions:

Name: Mitral Valve Disease 9 43
Rheumatic Mitral Valve Incompetence 9 11
Rheumatic Disease of Mitral Valve 9 60
Chronic Rheumatic Mitral Valve 9 60
Rheumatic Mitral Valve Regurgitation 9
Rheumatic Mitral Valve Changes 9
 
Rheumatic Mitral Insufficiency 9
Rheumatic Mitral Regurgitation 60
Diseases of Mitral Valve 60
Disease of Mitral Valve 9
Mitral Rh Valve Dis. 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1atrial fibrillation31.3AGTR1, NPPA, ACE, SELP
2mitral valve stenosis31.0NPPA, SELP
3orthostatic intolerance30.9AGTR1
4pulmonary hypertension30.8AGT, NPPA, TPH1, NOS3
5congestive heart failure30.7AGTR1, AGT, NPPA, ACE
6arteriosclerosis30.6NOS3
7nephrotic syndrome30.1AGT, NPPA, ACE
8coronary artery disease29.9SELP, AGTR1, AGT, NOS3, ACE
9ischemia29.5TGFB2, NOS3, AKT1, SELP, AGT
10sick sinus syndrome10.5NPPA
11hepatorenal syndrome10.5NPPA
12gitelman syndrome10.5AGT
13proliferative glomerulonephritis10.4SELP
14artery disease10.4
15cor pulmonale10.4NPPA, AGTR1
16renal tubular dysgenesis10.3AGT, AGTR1
17marfan syndrome10.3
18endocarditis10.3
19aneurysm10.3
20endotheliitis10.3
21conn's syndrome10.3NPPA, AGTR1
22muscle hypertrophy10.3
23aortic valve disease 210.3NPPA, AGT
24vesicoureteral reflux10.3AGTR1, AGT
25dilated cardiomyopathy10.2
26dysphagia10.2
27blindness10.2
28vascular disease10.2SELP, AKT1
29portal hypertension10.2NOS3, AGTR1
30idiopathic edema10.1ACE, NPPA
31nephrosclerosis10.1AGTR1, ACE
32pure autonomic failure10.1ACE, NPPA
33renal fibrosis10.1AGT, TGFB2, AGTR1
34systemic lupus erythematosus10.1
35migraine10.1
36mucopolysaccharidosis vii10.1
37end stage renal failure10.1
38ischemic heart disease10.1
39splenic abscess10.1
40polyarteritis nodosa10.1
41hyperlucent lung10.1
42pulmonary edema10.1
43cerebritis10.1
44thoracic aortic aneurysm10.1
45aortic aneurysm10.1
46infective endocarditis10.1
47intracranial aneurysm10.1
48lupus erythematosus10.1
49mucopolysaccharidosis10.1
50respiratory failure10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Symptoms for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

31
Heart, Lung, Endothelial, Brain, Smooth muscle, Testes, Kidney, Skin

Animal Models for Mitral Valve Disease or affiliated genes

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Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Development of atrial fibrillation in patients with rheumatic mitral valve disease in sinus rhythm. (25665684)
2015
2
Systolic cardiac function assessment by feature tracking echocardiography in dogs with myxomatous mitral valve disease. (25833040)
2015
3
Left atrial rupture secondary to myxomatous mitral valve disease in 11 dogs. (25251426)
2014
4
Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation. (25115553)
2014
5
Echocardiography in mitral valve disease. Preface. (23743080)
2013
6
The role of exercise echocardiography in the management of mitral valve disease. (23959848)
2013
7
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
8
Heritability of premature mitral valve disease in Cavalier King Charles spaniels. (20347358)
2011
9
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
10
Molecular changes in fibrillar collagen in myxomatous mitral valve disease. (19632135)
2010
11
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography. (21143934)
2010
12
Functional tricuspid regurgitation in mitral valve disease: epidemiology and prognostic implications. (20813320)
2010
13
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
14
Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. (21036114)
2010
15
Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs. (19324577)
2010
16
Acquired atrial septal defects secondary to rupture of the atrial septum in dogs with degenerative mitral valve disease. (20584637)
2010
17
Percutaneous surgery for mitral valve disease. (19875371)
2009
18
Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease. (19143935)
2009
19
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
20
Principles of reconstructive surgery in degenerative mitral valve disease. (17870003)
2007
21
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
22
Giant left atrium secondary to rheumatic mitral valve disease. (16849894)
2006
23
Surgical treatment of atrial fibrillation through isolation of the left atrial posterior wall in patients with chronic rheumatic mitral valve disease. A randomized study with control group. (15375469)
2004
24
Tissue Doppler properties of the left atrial appendage in patients with mitral valve disease. (15104544)
2004
25
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
26
The Quattro valve in rheumatic mitral valve disease: four-year follow up. (14658818)
2003
27
Location, size, and morphologic characteristics of left atrial thrombi as assessed by transesophageal echocardiography in relation to systemic embolism in patients with rheumatic mitral valve disease. (12633822)
2003
28
Encircling isolation of pulmonary vein orifice for elimination of persistent atrial fibrillation associated with mitral valve disease. (12974929)
2003
29
Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease. (12056726)
2002
30
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
31
Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. (11420162)
2001
32
Surgical repair of the prolapsing anterior leaflet in degenerative mitral valve disease. (10678378)
2000
33
Surgery for mitral valve disease in the pediatric age group. (10384192)
1999
34
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
35
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
36
Repair of chordae tendineae for rheumatic mitral valve disease. A twenty-year experience. (8551768)
1996
37
Left atrial performance indices in chronic mitral valve disease. (8564003)
1995
38
The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. (8043061)
1994
39
Combined warfarin and antiplatelet therapy after St. Jude Medical valve replacement for mitral valve disease. (8113551)
1994
40
Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease. (8174568)
1994
41
Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. (15636941)
1994
42
Significance of left atrial spontaneous echo contrast in rheumatic mitral valve disease as a predictor of systemic arterial embolization: a transesophageal echocardiographic study. (8154427)
1994
43
Diagnosis of left atrial thrombi in mitral valve disease by coronary arteriography. (1699665)
1990
44
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
45
Echocardiography in mitral valve disease: a review. (3916435)
1985
46
Mitral valve disease and dysphagia. (6241564)
1984
47
Conservative surgery for mitral valve disease: clinical and echocardiographic analysis of results. (6612646)
1983
48
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
49
Pulmonary edema after ritodrine infusion for premature labor in a patient with mitral valve disease. (7211242)
1981
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.5AKT1, CXCR4
29.5SELP, AKT1
39.5SELP, TGFB2
49.4TGFB2, AKT1
59.3NOS3, AKT1
69.3NOS3, AKT1
7
Show member pathways
9.3NOS3, AKT1
8
Show member pathways
Angiogenesis36
9.3AKT1, NOS3
99.3AGT, NPPA, AKT1
10
Show member pathways
9.1NPPA, AKT1, TGFB2
11
Show member pathways
9.1TGFB2, AKT1, AGT
129.0AKT1, NOS3, NPPA
13
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.0AKT1, NOS3, AGTR1
14
Show member pathways
8.9AKT1, CXCR4, NOS3
15
Show member pathways
8.8NOS3, AKT1, TGFB2
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6ACE, AKT1, TGFB2
17
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
8.6AGTR1, NOS3, CXCR4, AKT1
18
Show member pathways
8.4TGFB2, AKT1, CXCR4, NOS3
19
Show member pathways
8.4NOS3, CXCR4, AKT1, TGFB2
20
Show member pathways
8.4NOS3, AKT1, SELP, TGFB2
21
Show member pathways
8.3AGTR1, AGT, NOS3, ACE
22
Show member pathways
8.3TGFB2, AKT1, CXCR4, AGT, AGTR1
23
Show member pathways
7.9TGFB2, AKT1, ACE, AGT, AGTR1

Compounds for genes affiliated with Mitral Valve Disease

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Compounds related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1aliskiren43 1210.3AGTR1, AGT, ACE
2cilazapril43 1210.3ACE, AGTR1, NPPA
3trandolapril43 1210.3ACE, NPPA, AGTR1
4saralasin439.2AGTR1, ACE, AGT
5eprosartan43 28 1211.2AGT, ACE, AGTR1
6pd12331943 2810.2ACE, AGTR1, AGT
7fosinopril43 1210.1AGTR1, NPPA, ACE
8olmesartan43 28 1211.1AGTR1, ACE, AGT
9benazepril43 49 1211.1AGT, AGTR1, ACE, NPPA
10lisinopril43 49 24 1212.0NPPA, ACE, AGT, AGTR1
11enalapril43 49 1211.0AGTR1, ACE, NPPA, AGT
12quinapril43 49 1211.0SELP, AGTR1, ACE, NPPA
13captopril43 59 49 28 1213.0AGT, NPPA, ACE, AGTR1
14isosorbide dinitrate43 49 1210.9ACE, NPPA, NOS3
15enalaprilat438.9AGT, ACE, NPPA
16valsartan43 59 28 1211.9AGT, SELP, ACE, AGTR1
17prostaglandin438.9TGFB2, CXCR4, AGT, AGTR1, NPPA
18sele438.8SELP, ACE, AGT
19sodium nitroprusside438.8NPPA, SELP, TPH1, AGTR1, NOS3
20carvedilol43 49 28 1211.8AGTR1, ACE, NOS3, NPPA
21l-nmma438.7AKT1, AGTR1, AGT, NPPA, NOS3
22phenylephrine43 28 24 1211.7NOS3, NPPA, AGT, AGTR1, AKT1
23simvastatin43 49 59 28 24 1213.5AGTR1, SELP, NOS3, AKT1, AGT
24fluvastatin43 49 28 1211.5AGTR1, NOS3, ACE, SELP
25n acetylcysteine438.5AGTR1, AGT, SELP, TGFB2, AKT1
26epinephrine43 24 1210.5AGTR1, NPPA, SELP, AKT1, CXCR4, AGT
27perindopril43 49 1210.5NPPA, NOS3, ACE, AGTR1, AGT
28amlodipine43 49 24 1211.5AGT, AGTR1, NPPA, NOS3, ACE
29ang ii438.4AGTR1, ACE, NOS3, AGT, NPPA
30dopamine43 28 24 1211.4TPH1, TGFB2, AKT1, NPPA, AGTR1, AGT
31cyclosporin a43 28 5910.4SELP, AGT, CXCR4, NPPA, TGFB2, AGTR1
32sb 20358043 599.4AGTR1, NOS3, CXCR4, AKT1, AGT
33nitroglycerin43 129.4NOS3, AGTR1, NPPA, ACE, SELP
34candesartan43 49 28 1211.3AGTR1, NOS3, ACE, SELP, AGT
35norepinephrine43 24 1210.3ACE, TPH1, AGTR1, SELP, NPPA, AGT
36pge2438.2TGFB2, AGT, NPPA, CXCR4, AKT1, SELP
37aspirin43 49 28 2411.1NOS3, ACE, CXCR4, SELP, AGTR1
38losartan43 49 28 1211.1AGT, SELP, AKT1, ACE, NPPA, AGTR1
39atorvastatin43 49 28 24 1212.1SELP, AKT1, ACE, NOS3, AGT
40genistein43 28 59 2 24 1213.0AGTR1, AKT1, SELP, AGT, NOS3, TGFB2
41pravastatin43 49 28 24 1211.9SELP, ACE, NOS3, AGTR1
42acetylcholine43 49 28 24 1211.9TPH1, AKT1, ACE, NOS3, AGTR1, AGT
43dexamethasone43 49 28 1210.8AGT, AGTR1, SELP, TGFB2, CXCR4, AKT1
44arginine437.6NOS3, AGTR1, AGT, TPH1, NPPA, SELP
45creatinine437.6AGT, NPPA, ACE, AKT1, TGFB2, SELP
46prostacyclin437.5SELP, AKT1, ACE, NOS3, NPPA, AGT
47estrogen437.4TPH1, TGFB2, SELP, AGTR1, NOS3, NPPA
48vegf437.4AGT, NPPA, NOS3, CXCR4, AKT1, SELP
49calcium43 49 24 129.8TGFB2, ACE, AGTR1, AGT, NPPA, NOS3
50nitric oxide43 24 128.8TGFB2, CXCR4, TPH1, AGTR1, AGT, NPPA

GO Terms for genes affiliated with Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5SELP, CXCR4, ACE
2extracellular spaceGO:00056157.9AGT, NPPA, ACE, SELP, TGFB2
3plasma membraneGO:00058867.3AGTR1, NOS3, ACE, CXCR4, AKT1, SELP

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:000203410.2AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:003386410.1AGTR1, AGT
3regulation of renal sodium excretionGO:003581310.1AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, AGTR1
5positive regulation of cholesterol esterificationGO:001087310.1AGT, AGTR1
6low-density lipoprotein particle remodelingGO:003437410.1AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:020003799.9AGT, AGTR1
9regulation of blood vessel sizeGO:00508809.8NOS3, NPPA
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8AGT, AGTR1
11positive regulation of inflammatory responseGO:00507299.8AGTR1, AGT
12nitric oxide mediated signal transductionGO:00072639.7AGT, NOS3
13response to fluid shear stressGO:00344059.7AKT1, NOS3
14regulation of renal output by angiotensinGO:00020199.7AGT, ACE
15regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.7AGTR1, ACE
16germ cell developmentGO:00072819.7CXCR4, AKT1
17cellular response to mechanical stimulusGO:00712609.7AGT, NPPA, AKT1
18positive regulation of cellular protein metabolic processGO:00322709.6AKT1, AGT, AGTR1
19regulation of vasodilationGO:00423129.6AGTR1, ACE
20nitric oxide biosynthetic processGO:00068099.6NOS3, AKT1
21negative regulation of cell growthGO:00303089.6AGT, NPPA, TGFB2
22angiotensin maturationGO:00020039.6AGT, ACE
23regulation of nitric-oxide synthase activityGO:00509999.6AKT1, NOS3
24nitric oxide metabolic processGO:00462099.5AKT1, NOS3
25positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5TGFB2, SELP, AGT
26response to hypoxiaGO:00016669.5NPPA, CXCR4, TGFB2
27calcium-mediated signalingGO:00197229.4AGTR1, CXCR4
28regulation of vasoconstrictionGO:00192299.3AGTR1, AGT, ACE
29response to heatGO:00094089.3NOS3, AKT1
30kidney developmentGO:00018229.3AGTR1, AGT, ACE
31G-protein coupled receptor signaling pathwayGO:00071869.2AKT1, CXCR4, AGT, AGTR1
32platelet activationGO:00301689.2AKT1, SELP, TGFB2
33regulation of blood pressureGO:00082179.1ACE, NOS3, NPPA
34inflammatory responseGO:00069549.0SELP, AKT1, CXCR4
35blood coagulationGO:00075968.7TGFB2, SELP, AKT1, NOS3
36blood vessel remodelingGO:00019748.5AGT, NOS3, ACE, TGFB2

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:00317119.0AGTR1, ACE
2protein bindingGO:00055156.4SELP, AKT1, CXCR4, ACE, NOS3, AGT

Products for genes affiliated with Mitral Valve Disease

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Sources for Mitral Valve Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet