MCID: MTR012
MIFTS: 63

Mitral Valve Disease malady

Cardiovascular diseases category
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Summaries for Mitral Valve Disease

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Wikipedia:65 Mitral insufficiency (MI), mitral regurgitation or mitral incompetence is a disorder of the heart in... more...

MalaCards based summary: Mitral Valve Disease, also known as rheumatic mitral valve incompetence, is related to mitral valve stenosis and mitral valve prolapse. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are S1P3 pathway and amb2 Integrin signaling. The compounds aliskiren and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Mitral Valve Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Mitral Valve Disease, Aliases & Descriptions:

Name: Mitral Valve Disease 8 44
Rheumatic Mitral Valve Incompetence 8 10 62
Rheumatic Mitral Valve Regurgitation 8 62
Rheumatic Disease of Mitral Valve 8 62
Chronic Rheumatic Mitral Valve 8 62
Rheumatic Mitral Regurgitation 62
 
Rheumatic Mitral Insufficiency 8
Rheumatic Mitral Valve Changes 8
Diseases of Mitral Valve 62
Disease of Mitral Valve 8
Mitral Rh Valve Dis. 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1mitral valve stenosis31.0NPPA, SELP
2mitral valve prolapse30.9AGTR1
3pulmonary hypertension30.8AGT, NPPA, NOS3, TPH1
4thromboembolism30.8SELP, NOS3
5congestive heart failure30.7ACE, NPPA, AGT, AGTR1
6arteriosclerosis30.6NOS3
7hypertension30.3ACE, NOS3, NPPA, AGT, AGTR1
8nephrotic syndrome30.2AGT, NPPA, ACE
9sepsis29.8TGFB2, SELP, CXCR4, NOS3
10ischemia29.5AGT, NOS3, AKT1, SELP, TGFB2
11hypercholesterolemia29.5SELP, ACE, NOS3, AGT, AGTR1
12insulin resistance29.4AKT1, ACE, NOS3, AGT, AGTR1
13essential hypertension29.3SELP, ACE, NOS3, NPPA, AGT, AGTR1
14type 2 diabetes mellitus29.1SELP, AKT1, ACE, NOS3, AGT, AGTR1
15diabetes mellitus28.9SELP, AKT1, ACE, NOS3, NPPA, AGT
16sick sinus syndrome10.5NPPA
17hepatorenal syndrome10.5NPPA
18gitelman syndrome10.5AGT
19proliferative glomerulonephritis10.4SELP
20artery disease10.4
21cor pulmonale10.4AGTR1, NPPA
22renal tubular dysgenesis10.3AGT, AGTR1
23conn's syndrome10.3NPPA, AGTR1
24marfan syndrome10.3
25endocarditis10.3
26aneurysm10.3
27endotheliitis10.3
28aortic valve stenosis10.3AGT, NPPA
29vesicoureteral reflux10.3AGTR1, AGT
30dilated cardiomyopathy10.2
31williams syndrome10.2
32dysphagia10.2
33blindness10.2
34vascular disease10.2SELP, AKT1
35portal hypertension10.2NOS3, AGTR1
36idiopathic edema10.1NPPA, ACE
37nephrosclerosis10.1AGTR1, ACE
38pure autonomic failure10.1ACE, NPPA
39renal fibrosis10.1TGFB2, AGT, AGTR1
40end stage renal failure10.1
41familial hypercholesterolemia10.1
42ischemic heart disease10.1
43systemic lupus erythematosus10.1
44thoracic aortic aneurysm10.1
45splenic abscess10.1
46axenfeld-rieger syndrome10.1
47polyarteritis nodosa10.1
48hyperlucent lung10.1
49intracranial aneurysm10.1
50pulmonary edema10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Symptoms for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

32
Heart, Lung, Endothelial, Brain, Smooth muscle, Kidney, Skin, Testes

Animal Models for Mitral Valve Disease or affiliated genes

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Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Left atrial rupture secondary to myxomatous mitral valve disease in 11 dogs. (25251426)
2014
2
Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation. (25115553)
2014
3
Echocardiography in mitral valve disease. Preface. (23743080)
2013
4
The role of exercise echocardiography in the management of mitral valve disease. (23959848)
2013
5
Long-term results of the maze procedure on left ventricular function for persistent atrial fibrillation associated with mitral valve disease. (21331619)
2012
6
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
7
Heritability of premature mitral valve disease in Cavalier King Charles spaniels. (20347358)
2011
8
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
9
Molecular changes in fibrillar collagen in myxomatous mitral valve disease. (19632135)
2010
10
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography. (21143934)
2010
11
Functional tricuspid regurgitation in mitral valve disease: epidemiology and prognostic implications. (20813320)
2010
12
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
13
Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. (21036114)
2010
14
Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs. (19324577)
2010
15
Acquired atrial septal defects secondary to rupture of the atrial septum in dogs with degenerative mitral valve disease. (20584637)
2010
16
Percutaneous surgery for mitral valve disease. (19875371)
2009
17
Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease. (19143935)
2009
18
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
19
Principles of reconstructive surgery in degenerative mitral valve disease. (17870003)
2007
20
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
21
Giant left atrium secondary to rheumatic mitral valve disease. (16849894)
2006
22
Surgical treatment of atrial fibrillation through isolation of the left atrial posterior wall in patients with chronic rheumatic mitral valve disease. A randomized study with control group. (15375469)
2004
23
Tissue Doppler properties of the left atrial appendage in patients with mitral valve disease. (15104544)
2004
24
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
25
The Quattro valve in rheumatic mitral valve disease: four-year follow up. (14658818)
2003
26
Location, size, and morphologic characteristics of left atrial thrombi as assessed by transesophageal echocardiography in relation to systemic embolism in patients with rheumatic mitral valve disease. (12633822)
2003
27
Encircling isolation of pulmonary vein orifice for elimination of persistent atrial fibrillation associated with mitral valve disease. (12974929)
2003
28
Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease. (12056726)
2002
29
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
30
Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. (11420162)
2001
31
Surgical repair of the prolapsing anterior leaflet in degenerative mitral valve disease. (10678378)
2000
32
Surgery for mitral valve disease in the pediatric age group. (10384192)
1999
33
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
34
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
35
Repair of chordae tendineae for rheumatic mitral valve disease. A twenty-year experience. (8551768)
1996
36
Left atrial performance indices in chronic mitral valve disease. (8564003)
1995
37
The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. (8043061)
1994
38
Combined warfarin and antiplatelet therapy after St. Jude Medical valve replacement for mitral valve disease. (8113551)
1994
39
Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease. (8174568)
1994
40
Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. (15636941)
1994
41
Significance of left atrial spontaneous echo contrast in rheumatic mitral valve disease as a predictor of systemic arterial embolization: a transesophageal echocardiographic study. (8154427)
1994
42
Diagnosis of left atrial thrombi in mitral valve disease by coronary arteriography. (1699665)
1990
43
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
44
Echocardiography in mitral valve disease: a review. (3916435)
1985
45
Mitral valve disease and dysphagia. (6241564)
1984
46
Conservative surgery for mitral valve disease: clinical and echocardiographic analysis of results. (6612646)
1983
47
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
48
Pulmonary edema after ritodrine infusion for premature labor in a patient with mitral valve disease. (7211242)
1981
49
Werner's syndrome associated with mitral valve disease. (7275449)
1981
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Expression patterns in normal tissues for genes affiliated with Mitral Valve Disease

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Pathways for genes affiliated with Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.5AKT1, CXCR4
29.5SELP, AKT1
39.5SELP, TGFB2
49.4TGFB2, AKT1
59.3NOS3, AKT1
69.3NOS3, AKT1
7
Show member pathways
9.3NOS3, AKT1
8
Show member pathways
Angiogenesis37
9.3AKT1, NOS3
99.3AGT, NPPA, AKT1
10
Show member pathways
9.1NPPA, AKT1, TGFB2
11
Show member pathways
9.1TGFB2, AKT1, AGT
129.0AKT1, NOS3, NPPA
13
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0AKT1, NOS3, AGTR1
14
Show member pathways
8.9AKT1, CXCR4, NOS3
15
Show member pathways
8.8NOS3, AKT1, TGFB2
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6ACE, AKT1, TGFB2
17
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.6AGTR1, NOS3, CXCR4, AKT1
18
Show member pathways
8.4TGFB2, AKT1, CXCR4, NOS3
19
Show member pathways
8.4NOS3, CXCR4, AKT1, TGFB2
20
Show member pathways
8.4NOS3, AKT1, SELP, TGFB2
21
Show member pathways
8.3AGTR1, AGT, NOS3, ACE
22
Show member pathways
8.3TGFB2, AKT1, CXCR4, AGT, AGTR1
23
Show member pathways
7.9TGFB2, AKT1, ACE, AGT, AGTR1

Compounds for genes affiliated with Mitral Valve Disease

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Compounds related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1aliskiren44 1110.3AGTR1, AGT, ACE
2cilazapril44 1110.3ACE, AGTR1, NPPA
3trandolapril44 1110.3ACE, NPPA, AGTR1
4saralasin449.2AGTR1, ACE, AGT
5eprosartan44 28 1111.2AGT, ACE, AGTR1
6pd12331944 2810.2ACE, AGTR1, AGT
7fosinopril44 1110.1AGTR1, NPPA, ACE
8olmesartan44 28 1111.1AGTR1, ACE, AGT
9benazepril44 50 1111.1AGT, AGTR1, ACE, NPPA
10lisinopril44 50 24 1112.0NPPA, ACE, AGT, AGTR1
11enalapril44 50 1111.0AGTR1, ACE, NPPA, AGT
12quinapril44 50 1111.0SELP, AGTR1, ACE, NPPA
13captopril44 61 50 28 1113.0AGT, NPPA, ACE, AGTR1
14isosorbide dinitrate44 50 1110.9ACE, NPPA, NOS3
15enalaprilat448.9AGT, ACE, NPPA
16valsartan44 61 28 1111.9AGT, SELP, ACE, AGTR1
17prostaglandin448.9TGFB2, CXCR4, AGT, AGTR1, NPPA
18sele448.8SELP, ACE, AGT
19sodium nitroprusside448.8NPPA, SELP, TPH1, AGTR1, NOS3
20carvedilol44 50 28 1111.8AGTR1, ACE, NOS3, NPPA
21l-nmma448.7AKT1, AGTR1, AGT, NPPA, NOS3
22phenylephrine44 28 24 1111.7NOS3, NPPA, AGT, AGTR1, AKT1
23simvastatin44 50 61 28 24 1113.5AGTR1, SELP, NOS3, AKT1, AGT
24fluvastatin44 50 28 1111.5AGTR1, NOS3, ACE, SELP
25n acetylcysteine448.5AGTR1, AGT, SELP, TGFB2, AKT1
26epinephrine44 24 1110.5AGTR1, NPPA, SELP, AKT1, CXCR4, AGT
27perindopril44 50 1110.5NPPA, NOS3, ACE, AGTR1, AGT
28amlodipine44 50 24 1111.5AGT, AGTR1, NPPA, NOS3, ACE
29ang ii448.4AGTR1, ACE, NOS3, AGT, NPPA
30dopamine44 28 24 1111.4TPH1, TGFB2, AKT1, NPPA, AGTR1, AGT
31cyclosporin a44 28 6110.4SELP, AGT, CXCR4, NPPA, TGFB2, AGTR1
32sb 20358044 619.4AGTR1, NOS3, CXCR4, AKT1, AGT
33nitroglycerin44 119.4NOS3, AGTR1, NPPA, ACE, SELP
34candesartan44 50 28 1111.3AGTR1, NOS3, ACE, SELP, AGT
35norepinephrine44 24 1110.3ACE, TPH1, AGTR1, SELP, NPPA, AGT
36pge2448.2TGFB2, AGT, NPPA, CXCR4, AKT1, SELP
37aspirin44 50 28 2411.1NOS3, ACE, CXCR4, SELP, AGTR1
38losartan44 50 28 1111.1AGT, SELP, AKT1, ACE, NPPA, AGTR1
39atorvastatin44 50 28 24 1112.1SELP, AKT1, ACE, NOS3, AGT
40genistein44 28 61 2 24 1113.0AGTR1, AKT1, SELP, AGT, NOS3, TGFB2
41pravastatin44 50 28 24 1111.9SELP, ACE, NOS3, AGTR1
42acetylcholine44 50 28 24 1111.9TPH1, AKT1, ACE, NOS3, AGTR1, AGT
43dexamethasone44 50 28 1110.8AGT, AGTR1, SELP, TGFB2, CXCR4, AKT1
44arginine447.6NOS3, AGTR1, AGT, TPH1, NPPA, SELP
45creatinine447.6AGT, NPPA, ACE, AKT1, TGFB2, SELP
46prostacyclin447.5SELP, AKT1, ACE, NOS3, NPPA, AGT
47estrogen447.4TPH1, TGFB2, SELP, AGTR1, NOS3, NPPA
48vegf447.4AGT, NPPA, NOS3, CXCR4, AKT1, SELP
49calcium44 50 24 119.8TGFB2, ACE, AGTR1, AGT, NPPA, NOS3
50nitric oxide44 24 118.8TGFB2, CXCR4, TPH1, AGTR1, AGT, NPPA

GO Terms for genes affiliated with Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5SELP, CXCR4, ACE
2extracellular spaceGO:0056157.9AGT, NPPA, ACE, SELP, TGFB2
3plasma membraneGO:0058867.3AGTR1, NOS3, ACE, CXCR4, AKT1, SELP

Biological processes related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:00203410.2AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:03386410.1AGTR1, AGT
3regulation of renal sodium excretionGO:03581310.1AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:00201810.1AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.1AGT, AGTR1
6low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:20003799.9AGT, AGTR1
9regulation of blood vessel sizeGO:0508809.8NOS3, NPPA
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.8AGT, AGTR1
11positive regulation of inflammatory responseGO:0507299.8AGTR1, AGT
12nitric oxide mediated signal transductionGO:0072639.7AGT, NOS3
13response to fluid shear stressGO:0344059.7AKT1, NOS3
14regulation of renal output by angiotensinGO:0020199.7AGT, ACE
15regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.7AGTR1, ACE
16germ cell developmentGO:0072819.7CXCR4, AKT1
17cellular response to mechanical stimulusGO:0712609.7AGT, NPPA, AKT1
18positive regulation of cellular protein metabolic processGO:0322709.6AKT1, AGT, AGTR1
19regulation of vasodilationGO:0423129.6AGTR1, ACE
20nitric oxide biosynthetic processGO:0068099.6NOS3, AKT1
21negative regulation of cell growthGO:0303089.6AGT, NPPA, TGFB2
22angiotensin maturationGO:0020039.6AGT, ACE
23regulation of nitric-oxide synthase activityGO:0509999.6AKT1, NOS3
24nitric oxide metabolic processGO:0462099.5AKT1, NOS3
25positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5TGFB2, SELP, AGT
26response to hypoxiaGO:0016669.5NPPA, CXCR4, TGFB2
27calcium-mediated signalingGO:0197229.4AGTR1, CXCR4
28regulation of vasoconstrictionGO:0192299.3AGTR1, AGT, ACE
29response to heatGO:0094089.3NOS3, AKT1
30kidney developmentGO:0018229.3AGTR1, AGT, ACE
31G-protein coupled receptor signaling pathwayGO:0071869.2AKT1, CXCR4, AGT, AGTR1
32platelet activationGO:0301689.2AKT1, SELP, TGFB2
33regulation of blood pressureGO:0082179.1ACE, NOS3, NPPA
34inflammatory responseGO:0069549.0SELP, AKT1, CXCR4
35blood coagulationGO:0075968.7TGFB2, SELP, AKT1, NOS3
36blood vessel remodelingGO:0019748.5AGT, NOS3, ACE, TGFB2

Molecular functions related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.0AGTR1, ACE
2protein bindingGO:0055156.4SELP, AKT1, CXCR4, ACE, NOS3, AGT

Products for genes affiliated with Mitral Valve Disease

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Sources for Mitral Valve Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet