MCID: MTR012
MIFTS: 56

Mitral Valve Disease malady

Cardiovascular diseases category

Summaries for Mitral Valve Disease

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MalaCards: Mitral Valve Disease, also known as mitral and aortic valve disease, unspecified, is related to congestive heart failure and hypertension. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds norepinephrine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Mitral Valve Disease

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

mitral valve disease 8
mitral and aortic valve disease, unspecified 8
mitral and aortic valve disease nos 8
disease of mitral and aortic valves 8
diseases of mitral valve 60


External Ids:

Disease Ontology8 DOID:61
ICD9CM27 424.0
NCIt39 C78446
ICD1025 I05.9, I39.0

Related Diseases for Mitral Valve Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure30.8NPPA, AGTR1, AGT, ACE
2hypertension30.8NPPA, AGTR1, AGT, NOS3, ACE
3coronary artery disease30.7NPPA, AGTR1, AGT, CXCR4, NOS3, ACE
4mitral valve prolapse30.6AGTR1
5mitral valve stenosis30.5NPPA, SELP
6dilated cardiomyopathy30.3NPPA, ACE
7migraine30.1TPH1
8arteriosclerosis30.1NOS3
9nephrotic syndrome30.1ACE, AGT, NPPA
10ischemia30.1SELP, NOS3, AGT, AKT1
11chronic kidney failure30.1NPPA, AGTR1, AGT, NOS3, ACE
12ischemic heart disease30.1NPPA, AGTR1, AGT, NOS3, ACE, SELP
13essential hypertension30.1SELP, ACE, NOS3, AGT, AGTR1, NPPA
14type 2 diabetes mellitus30.1AKT1, AGTR1, AGT, NOS3, ACE, SELP
15diabetes mellitus30.1NPPA, AKT1, AGTR1, AGT, NOS3, ACE
16rheumatic disease of mitral valve10.9
17aortic disease10.8
18pulmonary valve disease10.8
19heart valve disease10.8
20vein disease10.6
21rheumatic tricuspid valve disease10.3
22aneurysm disease10.3
23bronchial disease10.3
24endocarditis10.3
25marfan syndrome10.2
26rheumatic pulmonary valve disease10.2
27brain disease10.2
28collagen disease10.2
29infective endocarditis10.2
30respiratory failure10.2
31ventricular septal defect10.2
32williams syndrome10.2
33axenfeld-rieger syndrome10.1
34hyperlucent lung10.1
35pulmonary edema10.1
36cerebritis10.1
37systemic lupus erythematosus10.1
38intracranial aneurysm10.1
39polyarteritis nodosa10.1
40coats disease10.1
41splenic abscess10.1
42dissecting aortic aneurysm10.1
43coronary thrombosis10.1
44end stage renal failure10.1
45rheumatic mitral valve incompetence10.1
46thoracic aortic aneurysm10.1
47familial hypercholesterolemia10.1
48aortic aneurysm10.1
49kidney disease10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Clinical Features for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mitral Valve Disease

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Search CenterWatch for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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32MalaCards
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MalaCards organs/tissues related to Mitral Valve Disease:

32
Heart, Lung, Brain, Endothelial, Testes, Kidney, Skin, Thyroid, Smooth muscle

Animal Models for Mitral Valve Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mitral Valve Disease:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2AGTR1, AGT, ACE
2MP:00053759.2TPH1, ACE, AGT
3MP:00053888.4AKT1, CXCR4, NOS3, TPH1
4MP:00053907.9TPH1, SELP, NOS3, CXCR4, AKT1
5MP:00053697.7NPPA, AKT1, AGT, CXCR4, NOS3, TPH1
6MP:00053707.6AKT1, AGT, NOS3, ACE, SELP
7MP:00053977.3NPPA, AKT1, CXCR4, NOS3, ACE, SELP
8MP:00053876.9AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
9MP:00053866.9AKT1, AGT, NOS3, ACE, SELP, TPH1
10MP:00107686.6AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
11MP:00053786.6AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
12MP:00053856.3TPH1, NPPA, AKT1, AGTR1, AGT, CXCR4
13MP:00053766.3NPPA, AKT1, AGTR1, AGT, CXCR4, NOS3

Publications for Mitral Valve Disease

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Sources:
50PubMed
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Articles related to Mitral Valve Disease:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Double orifice mitral valve in rheumatic heart disease. (24028525)
2014
2
Interrupted Commissural Band Annuloplasty for Degenerative Mitral Valve Disease. (24140215)
2013
3
Impact of preoperative atrial fibrillation on mortality and cardiovascular outcomes of mechanical mitral valve replacement for rheumatic mitral valve disease. (22621873)
2013
4
Relationship between incidentally detected calcification of the mitral valve on 64-row multidetector computed tomography and mitral valve disease on echocardiography. (23077412)
2012
5
Increased amount of atrial fibrosis in patients with atrial fibrillation secondary to mitral valve disease. (22014714)
2012
6
Artificial chordae for degenerative mitral valve disease: critical analysis of current techniques. (22962321)
2012
7
Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels. (22050842)
2012
8
Mitral valve disease in Marfan syndrome and related disorders. (21866385)
2011
9
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
10
Clinical practice. Mitral regurgitation due to degenerative mitral-valve disease. (20647211)
2010
11
Structural and cellular changes in canine myxomatous mitral valve disease: an image analysis study. (20329491)
2010
12
N-terminal pro B-type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease. (20070494)
2010
13
Percutaneous surgery for mitral valve disease. (19875371)
2009
14
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
15
Natural history of aortic valve disease following intervention for rheumatic mitral valve disease. (19301554)
2009
16
Use of the vertebral heart score in coughing dogs with chronic degenerative mitral valve disease. (19194070)
2009
17
child with Morquio syndrome and mixed mitral valve disease. (18590267)
2008
18
Mitral valve disease presentation and surgical outcome in African-American patients compared with white patients. (18154787)
2008
19
Surgery for atrial fibrillation in patients with mitral valve disease: results at five years from the International Registry of Atrial Fibrillation Surgery. (18374769)
2008
20
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
21
Long-term results of the Cox-Maze III procedure for persistent atrial fibrillation associated with rheumatic mitral valve disease: 10-year experience. (17158057)
2007
22
Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve disease. (16844549)
2006
23
Is posterior leaflet extension and associated commissurotomy effective in rheumatic mitral valve disease? Long-term outcome. (15562843)
2004
24
New insights into degenerative mitral valve disease in dogs. (15325478)
2004
25
Intraoperative assessment of mitral valve and peri-operative results of surgical treatment of mitral valve disease in patients who previously underwent closed surgical and percutaneous transluminal mitral commissurotomy. (14560347)
2003
26
Cardiopulmonary bypass strategy during concomitant surgical treatment of mitral valve disease and atrial fibrillation. (12705646)
2003
27
Repair versus replacement for degenerative mitral valve disease with coexisting ischemic heart disease. (12830055)
2003
28
Evaluation of clinical treatment of atrial fibrillation associated with rheumatic mitral valve disease by radiofrequency ablation. (11825731)
2002
29
Electrophysiological analysis of chronic atrial fibrillation associated with mitral valve disease by using spectral analysis. (11318009)
2001
30
Mitral regurgitation protects from left atrial thrombogenesis in patients with mitral valve disease and atrial fibrillation. (11139944)
2000
31
Superiority of mitral valve replacement with preservation of subvalvular structure to conventional replacement in severe rheumatic mitral valve disease: a modified technique and results of one-year follow up. (11041173)
2000
32
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
33
Left atrial ball thrombi without mitral valve disease treated by surgical removal. (9750439)
1998
34
Atrial dissociation after atrial compartment operation for chronic atrial fibrillation in mitral valve disease. (9584308)
1998
35
Comparative efficacy of the maze procedure for restoration of atrial contraction in patients with and without giant left atrium associated with mitral valve disease. (9562013)
1998
36
A modified maze procedure performed only on the left atrium for chronic atrial fibrillation associated with mitral valve disease: report of a case. (8919286)
1996
37
Spontaneous echo contrast on transthoracic echocardiography and left atrial thrombus in rheumatic mitral valve disease patients: a clinicopathologic study. (8001302)
1994
38
Does asymmetric mitral valve disease predict an adverse outcome after percutaneous balloon mitral valvotomy? An echocardiographic study. (1595546)
1992
39
Gaucher's disease with mitral valve calcification. (1614920)
1992
40
Historical note on hoarseness in mitral valve disease. (2909611)
1989
41
Key enzymes of myocardial energy metabolism in papillary muscle of patients with mitral valve disease--relation to left ventricular function. (2524875)
1989
42
Incidence, extent and localisation of left ventricular wall motion abnormalities in patients with mitral valve disease. (3727669)
1986
43
Embolism, thrombosis and anticoagulant haemorrhage in mitral valve disease. A prospective study of patients having valve replacement with the pericardial xenograft. (6519097)
1984
44
Surgical treatment of mitral valve disease: pathologic findings and atrial dysrhythmia. (6857300)
1983
45
Assessment of rheumatic mitral valve disease. Value of echocardiography in patients clinically suspected of predominant stenosis. (6821609)
1983
46
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
47
Pulmonary edema after ritodrine infusion for premature labor in a patient with mitral valve disease. (7211242)
1981
48
Critical assessment of two-dimensional echocardiographic estimation of the mitral valve area in rheumatic mitral valve disease: calcific deposits in the valve as a major determinant of the accuracy of the method. (7274280)
1981
49
Where are the diseases of yesteryear? DaCosta's syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and the mitral valve prolapse syndrome. (770030)
1976
50
Successful replacement of aortic and mitral valves with ball valve prostheses in a patient with rehumatic heart disease and SC hemoglobinopathy. (5101322)
1971

Genetic Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AGT
2
Hide members
10.0NOS3
3
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9.6AGT, AGTR1
49.1NOS3, AKT1
5
Hide members
9.1NOS3, AKT1
69.1AKT1, NOS3
78.8NOS3, AKT1, NPPA
8
Development PDGF signaling via STATs and NF-kB
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8.8AKT1, AGTR1, NOS3
98.4NOS3, CXCR4, AKT1, NPPA
10
Hide members
8.3CXCR4, AGT, AGTR1, AKT1
11
Hide members
8.1AKT1, AGTR1, AGT, ACE
12
Hide members
7.8NOS3, CXCR4, AGT, AGTR1, AKT1

Compounds for genes affiliated with Mitral Valve Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5TPH1
2estrogen4410.5TPH1
3losartan44 49 28 1112.6NPPA, AGT, SELP
4trandolapril44 1110.5ACE, NPPA, AGTR1
5cilazapril44 1110.5NPPA, AGTR1, ACE
6fosinopril44 1110.5NPPA, AGTR1, ACE
7ramipril44 1110.4ACE, NPPA, AGTR1
8aliskiren44 1110.3AGT, ACE, AGTR1
9isosorbide dinitrate44 49 1111.3NOS3, ACE, NPPA
10saralasin449.3ACE, AGT, AGTR1
11eprosartan44 28 1111.3ACE, AGTR1, AGT
12enalaprilat449.3NPPA, ACE, AGT
13kt 582344 2810.3NOS3, SELP, NPPA
14pd12331944 2810.3AGT, AGTR1, ACE
15olmesartan44 28 1111.3AGTR1, ACE, AGT
16metoprolol44 28 49 11 2413.3ACE, NPPA, NOS3
17chymostatin449.2AGTR1, AGT, ACE
18nitrendipine44 49 28 1112.2NPPA, AGTR1, ACE
19sele449.1AGT, SELP, ACE
20quinapril44 1110.1ACE, SELP, NPPA, AGTR1
21atenolol44 28 49 11 2413.1AGTR1, ACE, AGT
22benazepril44 1110.1AGT, AGTR1, NPPA, ACE
23lisinopril44 11 2411.1AGTR1, NPPA, AGT, ACE
24enalapril44 49 1111.0AGTR1, NPPA, AGT, ACE
25carvedilol44 49 28 1112.0ACE, NPPA, AGTR1, NOS3
26valsartan44 59 28 1111.9ACE, AGTR1, AGT, SELP
27telmisartan44 28 1110.9ACE, AGTR1, AGT
28sodium nitroprusside448.9TPH1, SELP, NOS3, AGTR1, NPPA
29guanylate448.7NOS3, NPPA, AGTR1, AGT
30doxazosin44 119.7AGTR1, ACE, SELP
31nitroglycerin44 119.6ACE, NPPA, AGTR1, SELP, NOS3
32perindopril44 49 1110.6AGT, AGTR1, NPPA, ACE, NOS3
33amlodipine44 49 11 2411.6NPPA, AGTR1, AGT, NOS3, ACE
34ang ii448.5NPPA, AGTR1, NOS3, ACE, AGT
35aspirin44 49 28 2411.4SELP, ACE, NOS3, AGTR1, CXCR4
36candesartan44 28 1110.4AGTR1, SELP, ACE, AGT, NOS3
37l-nmma448.3NOS3, AGT, AKT1, NPPA, AGTR1
38phenylephrine44 28 11 2411.3NPPA, NOS3, AGT, AGTR1, AKT1
39atorvastatin44 49 28 11 2412.2NOS3, SELP, AGT, AKT1
40simvastatin44 49 59 28 11 2413.2NOS3, AGT, AGTR1, AKT1, SELP
41sb 20358044 599.1AGT, AGTR1, CXCR4, NOS3, AKT1
42actinomycin d448.0AKT1, AGT, CXCR4, AGTR1, NOS3
43epinephrine44 11 2410.0NPPA, SELP, CXCR4, AGT, AKT1, AGTR1
44ly294002448.0AGT, SELP, CXCR4, NOS3, AKT1
45creatinine447.7AKT1, NPPA, SELP, ACE, AGTR1, AGT
46acetylcholine44 49 28 11 2411.7AKT1, AGT, NOS3, ACE, TPH1, AGTR1
47vegf447.4SELP, NOS3, CXCR4, AGT, AGTR1, AKT1
48nitric oxide44 11 249.3ACE, SELP, AGT, NPPA, AGTR1, NOS3
49prostacyclin447.3NOS3, NPPA, AKT1, AGTR1, AGT, ACE
50arginine447.1TPH1, NPPA, AKT1, SELP, AGTR1, AGT

GO Terms for genes affiliated with Mitral Valve Disease

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16Gene Ontology
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Cellular components related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0SELP, ACE, CXCR4

Biological processes related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:0338649.9AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:0020349.9AGTR1, AGT
3renin-angiotensin regulation of aldosterone productionGO:0020189.9AGT, AGTR1
4regulation of renal sodium excretionGO:0358139.9AGT, AGTR1
5positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
6low-density lipoprotein particle remodelingGO:0343749.8AGTR1, AGT
7regulation of blood vessel sizeGO:0508809.8NPPA, NOS3
8regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8ACE, AGTR1
9regulation of vasodilationGO:0423129.7AGTR1, ACE
10positive regulation of macrophage derived foam cell differentiationGO:0107449.7AGT, AGTR1
11regulation of renal output by angiotensinGO:0020199.7ACE, AGT
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.6AGT, AGTR1
13angiotensin maturationGO:0020039.6ACE, AGT
14nitric oxide mediated signal transductionGO:0072639.5NOS3, AGT
15positive regulation of reactive oxygen species metabolic processGO:20003799.5AGT, AGTR1
16response to fluid shear stressGO:0344059.4AKT1, NOS3
17nitric oxide biosynthetic processGO:0068099.3NOS3, AKT1
18regulation of blood pressureGO:0082179.3NPPA, NOS3, ACE
19regulation of vasoconstrictionGO:0192299.3ACE, AGT, AGTR1
20kidney developmentGO:0018229.2ACE, AGT, AGTR1
21nitric oxide metabolic processGO:0462099.2NOS3, AKT1
22blood vessel remodelingGO:0019749.2AGT, NOS3, ACE
23regulation of nitric-oxide synthase activityGO:0509999.1AKT1, NOS3
24positive regulation of cellular protein metabolic processGO:0322709.1AGT, AGTR1, AKT1
25germ cell developmentGO:0072818.9CXCR4, AKT1
26G-protein coupled receptor signaling pathwayGO:0071868.7CXCR4, AGT, AGTR1, AKT1

Molecular functions related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.5ACE, AGTR1
2acetyltransferase activator activityGO:0106989.3AGT, AGTR1

Products for genes affiliated with Mitral Valve Disease

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Mitral Valve Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet