MCID: MTR012
MIFTS: 62

Mitral Valve Disease malady

Cardiovascular diseases category

Summaries for Mitral Valve Disease

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66Wikipedia, 34MalaCards
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Wikipedia:66 Mitral insufficiency (MI), mitral regurgitation or mitral incompetence is a disorder of the heart in... more...

MalaCards: Mitral Valve Disease, also known as rheumatic mitral valve incompetence, is related to congestive heart failure and hypertension. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are S1P3 pathway and amb2 Integrin signaling. The compounds aliskiren and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Mitral Valve Disease

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

mitral valve disease 9 46
rheumatic mitral valve incompetence 9 11
rheumatic mitral valve regurgitation 9
rheumatic disease of mitral valve 9
rheumatic mitral insufficiency 9
rheumatic mitral valve changes 9
chronic rheumatic mitral valve 9
diseases of mitral valve 63
disease of mitral valve 9
mitral rh valve dis. 9


Related Diseases for Mitral Valve Disease

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18GeneCards, 19GeneDecks
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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure30.8AGTR1, AGT, NPPA, ACE
2hypertension30.7NOS3, AGTR1, ACE, NPPA, AGT
3thromboembolism30.7NOS3, SELP
4mitral valve stenosis30.6NPPA, SELP
5coronary artery disease30.4SELP, AGTR1, AGT, NOS3, ACE
6mitral valve prolapse30.3AGTR1
7arteriosclerosis30.2NOS3
8nephrotic syndrome30.1AGT, NPPA, ACE
9sepsis30.0TGFB2, SELP, CXCR4, NOS3
10ischemia30.0TGFB2, NOS3, AKT1, SELP, AGT
11hypercholesterolemia30.0AGTR1, AGT, NOS3, SELP, ACE
12insulin resistance29.9AGT, NOS3, ACE, AGTR1, AKT1
13essential hypertension29.9AGTR1, ACE, AGT, NPPA, SELP, NOS3
14type 2 diabetes mellitus29.9AKT1, ACE, NOS3, SELP, AGTR1, AGT
15diabetes mellitus29.8NPPA, AGT, SELP, NOS3, ACE, AKT1
16artery disease10.4
17endocarditis10.3
18aneurysm10.3
19marfan syndrome10.2
20dilated cardiomyopathy10.2
21williams syndrome10.2
22dysphagia10.2
23blindness10.2
24endotheliitis10.2
25sick sinus syndrome10.1NPPA
26hepatorenal syndrome10.1NPPA
27gitelman syndrome10.1AGT
28proliferative glomerulonephritis10.1SELP
29cor pulmonale10.1NPPA, AGTR1
30intracranial aneurysm10.1
31splenic abscess10.1
32polyarteritis nodosa10.1
33end stage renal failure10.1
34hyperlucent lung10.1
35cerebritis10.1
36systemic lupus erythematosus10.1
37familial hypercholesterolemia10.1
38thoracic aortic aneurysm10.1
39axenfeld-rieger syndrome10.1
40aortic aneurysm10.1
41aortic valve disease10.1
42infective endocarditis10.1
43lupus erythematosus10.1
44migraine10.1
45mucopolysaccharidosis10.1
46respiratory failure10.1
47ventricular septal defect10.1
48aortic coarctation10.1
49cor triatriatum10.1
50pectus carinatum10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Symptoms for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Mitral Valve Disease

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Search CenterWatch for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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34MalaCards
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MalaCards organs/tissues related to Mitral Valve Disease:

34
Heart, Lung, Endothelial, Brain, Testes, Smooth muscle, Kidney, Skin

Animal Models for Mitral Valve Disease or affiliated genes

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Sources:
38MGI
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Publications for Mitral Valve Disease

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53PubMed
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Articles related to Mitral Valve Disease:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Echocardiography in mitral valve disease. Preface. (23743080)
2013
2
The role of exercise echocardiography in the management of mitral valve disease. (23959848)
2013
3
Evaluation of 3-methylhistidine levels in dogs with chronic mitral valve disease. (23542657)
2013
4
Long-term results of the maze procedure on left ventricular function for persistent atrial fibrillation associated with mitral valve disease. (21331619)
2012
5
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
6
Heritability of premature mitral valve disease in Cavalier King Charles spaniels. (20347358)
2011
7
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
8
Molecular changes in fibrillar collagen in myxomatous mitral valve disease. (19632135)
2010
9
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography. (21143934)
2010
10
Functional tricuspid regurgitation in mitral valve disease: epidemiology and prognostic implications. (20813320)
2010
11
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
12
Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. (21036114)
2010
13
Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs. (19324577)
2010
14
Acquired atrial septal defects secondary to rupture of the atrial septum in dogs with degenerative mitral valve disease. (20584637)
2010
15
Percutaneous surgery for mitral valve disease. (19875371)
2009
16
Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease. (19143935)
2009
17
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
18
Principles of reconstructive surgery in degenerative mitral valve disease. (17870003)
2007
19
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
20
Giant left atrium secondary to rheumatic mitral valve disease. (16849894)
2006
21
Surgical treatment of atrial fibrillation through isolation of the left atrial posterior wall in patients with chronic rheumatic mitral valve disease. A randomized study with control group. (15375469)
2004
22
Tissue Doppler properties of the left atrial appendage in patients with mitral valve disease. (15104544)
2004
23
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
24
The Quattro valve in rheumatic mitral valve disease: four-year follow up. (14658818)
2003
25
Location, size, and morphologic characteristics of left atrial thrombi as assessed by transesophageal echocardiography in relation to systemic embolism in patients with rheumatic mitral valve disease. (12633822)
2003
26
Encircling isolation of pulmonary vein orifice for elimination of persistent atrial fibrillation associated with mitral valve disease. (12974929)
2003
27
Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease. (12056726)
2002
28
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
29
Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. (11420162)
2001
30
Surgical repair of the prolapsing anterior leaflet in degenerative mitral valve disease. (10678378)
2000
31
Surgery for mitral valve disease in the pediatric age group. (10384192)
1999
32
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
33
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
34
Repair of chordae tendineae for rheumatic mitral valve disease. A twenty-year experience. (8551768)
1996
35
Left atrial performance indices in chronic mitral valve disease. (8564003)
1995
36
The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. (8043061)
1994
37
Combined warfarin and antiplatelet therapy after St. Jude Medical valve replacement for mitral valve disease. (8113551)
1994
38
Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease. (8174568)
1994
39
Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. (15636941)
1994
40
Significance of left atrial spontaneous echo contrast in rheumatic mitral valve disease as a predictor of systemic arterial embolization: a transesophageal echocardiographic study. (8154427)
1994
41
Diagnosis of left atrial thrombi in mitral valve disease by coronary arteriography. (1699665)
1990
42
Clinical and hemodynamic profile of patients with calcific mitral valve disease. (2098311)
1990
43
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
44
Echocardiography in mitral valve disease: a review. (3916435)
1985
45
Mitral valve disease and dysphagia. (6241564)
1984
46
Clinical thromboembolism, atrial dysrhythmia and left atrial thrombus in surgically treated patients with mitral valve disease. (6724632)
1984
47
Conservative surgery for mitral valve disease: clinical and echocardiographic analysis of results. (6612646)
1983
48
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
49
Werner's syndrome associated with mitral valve disease. (7275449)
1981
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 5Cell Signaling Technology, 54QIAGEN, 61Thomson Reuters, 52PharmGKB
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Pathways related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
S1P2 pathway39
S1P4 pathway39
S1P5 pathway39
S1P1 pathway39
Sphingosine 1-phosphate (S1P) pathway39
9.5AKT1, CXCR4
29.5SELP, AKT1
39.5SELP, TGFB2
49.4TGFB2, AKT1
59.3NOS3, AKT1
69.3NOS3, AKT1
7
Show member pathways
9.3NOS3, AKT1
8
Show member pathways
Angiogenesis39
9.3AKT1, NOS3
99.3AGT, NPPA, AKT1
10
Show member pathways
9.1NPPA, AKT1, TGFB2
11
Show member pathways
9.1TGFB2, AKT1, AGT
129.0AKT1, NOS3, NPPA
13
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.0AKT1, NOS3, AGTR1
14
Show member pathways
8.9AKT1, CXCR4, NOS3
15
Show member pathways
8.8NOS3, AKT1, TGFB2
16
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.6ACE, AKT1, TGFB2
17
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
8.6AGTR1, NOS3, CXCR4, AKT1
18
Show member pathways
8.4TGFB2, AKT1, CXCR4, NOS3
19
Show member pathways
8.4NOS3, CXCR4, AKT1, TGFB2
20
Show member pathways
8.4NOS3, AKT1, SELP, TGFB2
21
Show member pathways
8.3AGTR1, AGT, NOS3, ACE
22
Show member pathways
8.3TGFB2, AKT1, CXCR4, AGT, AGTR1
23
Show member pathways
7.9TGFB2, AKT1, ACE, AGT, AGTR1

Compounds for genes affiliated with Mitral Valve Disease

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1aliskiren46 1210.3AGTR1, AGT, ACE
2cilazapril46 1210.3ACE, AGTR1, NPPA
3trandolapril46 1210.3ACE, NPPA, AGTR1
4saralasin469.2AGTR1, ACE, AGT
5eprosartan46 30 1211.2AGT, ACE, AGTR1
6pd12331946 3010.2ACE, AGTR1, AGT
7fosinopril46 1210.1AGTR1, NPPA, ACE
8olmesartan46 30 1211.1AGTR1, ACE, AGT
9benazepril46 52 1211.1AGT, AGTR1, ACE, NPPA
10lisinopril46 52 25 1212.0NPPA, ACE, AGT, AGTR1
11enalapril46 52 1211.0AGTR1, ACE, NPPA, AGT
12quinapril46 52 1211.0SELP, AGTR1, ACE, NPPA
13captopril46 62 52 30 1213.0AGT, NPPA, ACE, AGTR1
14isosorbide dinitrate46 52 1210.9ACE, NPPA, NOS3
15enalaprilat468.9AGT, ACE, NPPA
16valsartan46 62 30 1211.9AGT, SELP, ACE, AGTR1
17prostaglandin468.9TGFB2, CXCR4, AGT, AGTR1, NPPA
18sele468.8SELP, ACE, AGT
19sodium nitroprusside468.8NPPA, SELP, TPH1, AGTR1, NOS3
20carvedilol46 52 30 1211.8AGTR1, ACE, NOS3, NPPA
21l-nmma468.7AKT1, AGTR1, AGT, NPPA, NOS3
22phenylephrine46 30 25 1211.7NOS3, NPPA, AGT, AGTR1, AKT1
23simvastatin46 52 62 30 25 1213.5AGTR1, SELP, NOS3, AKT1, AGT
24fluvastatin46 52 30 1211.5AGTR1, NOS3, ACE, SELP
25n acetylcysteine468.5AGTR1, AGT, SELP, TGFB2, AKT1
26epinephrine46 25 1210.5AGTR1, NPPA, SELP, AKT1, CXCR4, AGT
27perindopril46 52 1210.5NPPA, NOS3, ACE, AGTR1, AGT
28amlodipine46 52 25 1211.5AGT, AGTR1, NPPA, NOS3, ACE
29ang ii468.4AGTR1, ACE, NOS3, AGT, NPPA
30dopamine46 30 25 1211.4TPH1, TGFB2, AKT1, NPPA, AGTR1, AGT
31cyclosporin a46 30 6210.4SELP, AGT, CXCR4, NPPA, TGFB2, AGTR1
32sb 20358046 629.4AGTR1, NOS3, CXCR4, AKT1, AGT
33nitroglycerin46 129.4NOS3, AGTR1, NPPA, ACE, SELP
34candesartan46 52 30 1211.3AGTR1, NOS3, ACE, SELP, AGT
35norepinephrine46 25 1210.3ACE, TPH1, AGTR1, SELP, NPPA, AGT
36pge2468.2TGFB2, AGT, NPPA, CXCR4, AKT1, SELP
37aspirin46 52 30 2511.1NOS3, ACE, CXCR4, SELP, AGTR1
38losartan46 52 30 1211.1AGT, SELP, AKT1, ACE, NPPA, AGTR1
39atorvastatin46 52 30 25 1212.1SELP, AKT1, ACE, NOS3, AGT
40genistein46 30 62 3 25 1213.0AGTR1, AKT1, SELP, AGT, NOS3, TGFB2
41pravastatin46 52 30 25 1211.9SELP, ACE, NOS3, AGTR1
42acetylcholine46 52 30 25 1211.9TPH1, AKT1, ACE, NOS3, AGTR1, AGT
43dexamethasone46 52 30 1210.8AGT, AGTR1, SELP, TGFB2, CXCR4, AKT1
44arginine467.6NOS3, AGTR1, AGT, TPH1, NPPA, SELP
45creatinine467.6AGT, NPPA, ACE, AKT1, TGFB2, SELP
46prostacyclin467.5SELP, AKT1, ACE, NOS3, NPPA, AGT
47estrogen467.4TPH1, TGFB2, SELP, AGTR1, NOS3, NPPA
48vegf467.4AGT, NPPA, NOS3, CXCR4, AKT1, SELP
49calcium46 52 25 129.8TGFB2, ACE, AGTR1, AGT, NPPA, NOS3
50nitric oxide46 25 128.8TGFB2, CXCR4, TPH1, AGTR1, AGT, NPPA

GO Terms for genes affiliated with Mitral Valve Disease

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Sources:
17Gene Ontology
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Cellular components related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5SELP, CXCR4, ACE
2extracellular spaceGO:0056157.9AGT, NPPA, ACE, SELP, TGFB2
3plasma membraneGO:0058867.3AGTR1, NOS3, ACE, CXCR4, AKT1, SELP

Biological processes related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:00203410.2AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:03386410.1AGTR1, AGT
3regulation of renal sodium excretionGO:03581310.1AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:00201810.1AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.1AGT, AGTR1
6low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:20003799.9AGT, AGTR1
9regulation of blood vessel sizeGO:0508809.8NOS3, NPPA
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.8AGT, AGTR1
11positive regulation of inflammatory responseGO:0507299.8AGTR1, AGT
12nitric oxide mediated signal transductionGO:0072639.7AGT, NOS3
13response to fluid shear stressGO:0344059.7AKT1, NOS3
14regulation of renal output by angiotensinGO:0020199.7AGT, ACE
15regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.7AGTR1, ACE
16germ cell developmentGO:0072819.7CXCR4, AKT1
17cellular response to mechanical stimulusGO:0712609.7AGT, NPPA, AKT1
18positive regulation of cellular protein metabolic processGO:0322709.6AKT1, AGT, AGTR1
19regulation of vasodilationGO:0423129.6AGTR1, ACE
20nitric oxide biosynthetic processGO:0068099.6NOS3, AKT1
21negative regulation of cell growthGO:0303089.6AGT, NPPA, TGFB2
22angiotensin maturationGO:0020039.6AGT, ACE
23regulation of nitric-oxide synthase activityGO:0509999.6AKT1, NOS3
24nitric oxide metabolic processGO:0462099.5AKT1, NOS3
25positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5TGFB2, SELP, AGT
26response to hypoxiaGO:0016669.5NPPA, CXCR4, TGFB2
27calcium-mediated signalingGO:0197229.4AGTR1, CXCR4
28regulation of vasoconstrictionGO:0192299.3AGTR1, AGT, ACE
29response to heatGO:0094089.3NOS3, AKT1
30kidney developmentGO:0018229.3AGTR1, AGT, ACE
31G-protein coupled receptor signaling pathwayGO:0071869.2AKT1, CXCR4, AGT, AGTR1
32platelet activationGO:0301689.2AKT1, SELP, TGFB2
33regulation of blood pressureGO:0082179.1ACE, NOS3, NPPA
34inflammatory responseGO:0069549.0SELP, AKT1, CXCR4
35blood coagulationGO:0075968.7TGFB2, SELP, AKT1, NOS3
36blood vessel remodelingGO:0019748.5AGT, NOS3, ACE, TGFB2

Molecular functions related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.0AGTR1, ACE
2protein bindingGO:0055156.4SELP, AKT1, CXCR4, ACE, NOS3, AGT

Products for genes affiliated with Mitral Valve Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitral Valve Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet