MCID: MTR012
MIFTS: 58

Mitral Valve Disease malady

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Disease

Aliases & Descriptions for Mitral Valve Disease:

Name: Mitral Valve Disease 12 52 14
Chronic Rheumatic Mitral Valve 12 69
Disease of Mitral Valve 12 29
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Rheumatic Mitral Insufficiency 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 69
Diseases of Mitral Valve 69
Mitral Rh Valve Dis. 12

Classifications:



Summaries for Mitral Valve Disease

MalaCards based summary : Mitral Valve Disease, also known as chronic rheumatic mitral valve, is related to mitral valve stenosis and loeys-dietz syndrome 5. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are Integrin Pathway and p70S6K Signaling. The drugs Epinephrine and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Mitral Valve Disease

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 mitral valve stenosis 11.3
2 loeys-dietz syndrome 5 11.1
3 cardiac valvular dysplasia, x-linked 11.0
4 orthostatic intolerance 10.9
5 atrial fibrillation 10.6
6 penile cancer, childhood 10.3 ACE AGT
7 prostate neuroendocrine neoplasm 10.2 ACE AGT AGTR1
8 preaxial polydactyly of fingers 10.2 ACE AGT AGTR1
9 cascade stomach 10.2 ACE AGT AGTR1
10 clear cell adenocarcinoma 10.2 ACE AGTR1 NPPA
11 hyperuricemic nephropathy, familial juvenile 2 10.2 ACE AGT AGTR1
12 cetp-related hyperalphalipoproteinemia 10.2 ACE AGT AGTR1
13 flat umbilicus familial 10.2 ACE AGT AGTR1
14 agammaglobulinemia 6 10.2 ACE AGT AGTR1
15 familial nasal acilia 10.2 AGT AGTR1 NPPA
16 rapidly progressive glomerulonephritis 10.2 ACE NOS3 NPPA
17 algoneurodystrophy 10.2 FBN1 MMP1 TGFB2
18 pulmonary hypertension 10.2
19 congestive heart failure 10.2
20 alpha-2-plasmin inhibitor deficiency 10.2 ACE AGTR1 NOS3
21 systolic heart failure 10.2 ACE AGT AGTR1
22 acute posterior multifocal placoid pigment epitheliopathy 10.2 ACE AGTR1 NOS3
23 hypogonadism mitral valve prolapse mental retardation 10.2 ACE NPPA
24 familial nephrotic syndrome 10.2 ACE AGT AGTR1
25 citrullinemia, type ii, neonatal-onset 10.1 ACE AGTR1 NOS3
26 welander distal myopathy 10.1 AGT AGTR1 NOS3
27 budd-chiari syndrome 10.1 ACE AGTR1 AKT1 NOS3
28 central nervous system teratoma 10.1 FBN1 MMP1 MMP13
29 tuberculous peritonitis 10.1 IL10 SLC6A4 TPH1
30 mixed ductal-endocrine carcinoma 10.0 FBN1 MMP1 MMP13
31 iris disease 10.0 ACE AGT AGTR1 NOS3 NPPA
32 inferolateral myocardial infarct 10.0 ACE NPPA NPPB
33 aplasia cutis congenita recessive 10.0 ACE AGT AGTR1 FBN1 NOS3
34 syringomelia hyperkeratosis 10.0 ACE NPPA NPPB
35 kartagener syndrome 10.0 ACE NOS3
36 petrositis 10.0 ACE AGTR1 NPPB
37 median neuropathy 10.0 ACE FBN1 NPPB
38 iida kannari syndrome 10.0 ACE NPPA NPPB
39 cardiomyopathy 10.0
40 histidine metabolism disease 10.0 NOS3 NPPA NPPB
41 deafness, autosomal recessive 79 10.0 ACE FBN1 NPPB
42 coronary artery disease 10.0
43 dilated cardiomyopathy 10.0
44 artery disease 10.0
45 endotheliitis 10.0
46 critical limb ischemia 9.9 ACE AGTR1 NPPA NPPB
47 diabetic encephalopathy 9.9 ACE NOS3 NPPB
48 joint disorders 9.9 ACE AGTR1 NOS3 NPPB
49 adams-oliver syndrome 9.9 ACE AGT NPPA NPPB
50 marfan syndrome 9.9

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 84)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Anxiety Disorder
Aortic Atherosclerosis Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchiectasis Bronchitis
Cardiac Arrest Cardiogenic Shock
Cardiomyopathy, Familial Hypertrophic Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Constrictive Pericarditis
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Dressler's Syndrome Dyskinesia of Esophagus
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Conduction Disease
Heart Disease Hepatitis
Hyperlipidemia, Familial Combined Hyperlipoproteinemia Type Iv
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis
Hypoglycemia Hypothyroidism
Idiopathic Interstitial Pneumonia Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia
Irritable Bowel Syndrome Ischemic Heart Disease

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease

Symptoms & Phenotypes for Mitral Valve Disease

MGI Mouse Phenotypes related to Mitral Valve Disease:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 PTK2 SLC6A4 TGFB2 TPH1 ACE ADAM17
2 homeostasis/metabolism MP:0005376 10.41 SLC6A4 TGFB2 TPH1 ACE ADAM17 AGT
3 growth/size/body region MP:0005378 10.38 ACE ADAM17 AGT AGTR1 AKT1 CXCR4
4 immune system MP:0005387 10.27 AGT AGTR1 AKT1 CXCR4 FBN1 IL10
5 hematopoietic system MP:0005397 10.26 ACE ADAM17 AGTR1 AKT1 CXCR4 FBN1
6 endocrine/exocrine gland MP:0005379 10.25 SLC6A4 TGFB2 ACE ADAM17 AKT1 CXCR4
7 mortality/aging MP:0010768 10.21 ACE ADAM17 AGT AGTR1 AKT1 CXCR4
8 muscle MP:0005369 10.18 ADAM17 AGT AKT1 CXCR4 FBN1 IL10
9 adipose tissue MP:0005375 10.11 ACE AGT AGTR1 AKT1 FBN1 NOS3
10 integument MP:0010771 10.08 FBN1 IL10 MMP13 PTK2 SLC6A4 TPH1
11 nervous system MP:0003631 10.06 AGT AGTR1 AKT1 CXCR4 FBN1 IL10
12 limbs/digits/tail MP:0005371 10 ADAM17 FBN1 IL10 MMP13 NOS3 PTK2
13 renal/urinary system MP:0005367 9.86 ACE AGT AGTR1 CXCR4 FBN1 NOS3
14 neoplasm MP:0002006 9.85 ACE AKT1 CXCR4 IL10 MMP1 PTK2
15 reproductive system MP:0005389 9.85 ACE ADAM17 AGT AKT1 CXCR4 FBN1
16 respiratory system MP:0005388 9.61 ADAM17 AKT1 CXCR4 FBN1 IL10 NOS3
17 skeleton MP:0005390 9.28 ADAM17 AKT1 CXCR4 FBN1 IL10 MMP13

Drugs & Therapeutics for Mitral Valve Disease

Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3 37350-58-6, 51384-51-1 4171
3
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
6
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
7
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
8
Norepinephrine Approved Phase 4 51-41-2 439260
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
11
Candesartan Approved Phase 4 139481-59-7 2541
12
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
13
Cabergoline Approved Phase 4 81409-90-7 54746
14
Dobutamine Approved Phase 4 34368-04-2 36811
15
Sevelamer Approved Phase 4 52757-95-6, 152751-57-0 3085017
16
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
17
Etomidate Approved Phase 4 33125-97-2 36339 667484
18
Cosyntropin Approved Phase 4 16960-16-0 16129617
19
Calcium acetate Approved Phase 4 62-54-4
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Acetaminophen Approved Phase 4 103-90-2 1983
22
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
23
Rivaroxaban Approved Phase 4,Phase 2 366789-02-8
24
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
25
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
28
Phenprocoumon Approved Phase 4 435-97-2 9908 54680692
29
Menadione Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-27-5 4055
30
Phytonadione Approved, Nutraceutical Phase 4,Phase 2,Phase 3 84-80-0 4812 5284607
31
Butyric Acid Experimental Phase 4 107-92-6 264
32
Angiotensin II Phase 4,Phase 3 68521-88-0, 11128-99-7 65143 172198
33 Analgesics Phase 4,Phase 2
34
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Serine Proteinase Inhibitors Phase 4,Phase 2
36 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Narcotics Phase 4
38 Adrenergic Antagonists Phase 4,Phase 2,Phase 3,Phase 1
39 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
40 Coagulants Phase 4,Phase 2,Phase 3
41 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 2,Phase 3
42 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Sympatholytics Phase 4,Phase 2,Phase 3
45 Cyclooxygenase Inhibitors Phase 4,Phase 2
46 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
47 Hemostatics Phase 4,Phase 2,Phase 3
48 Analgesics, Non-Narcotic Phase 4,Phase 2
49 Trace Elements Phase 4,Phase 2,Phase 3
50 Analgesics, Opioid Phase 4

Interventional clinical trials:

(show top 50) (show all 306)
id Name Status NCT ID Phase
1 Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Unknown status NCT01536717 Phase 4
2 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4
3 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
4 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4
5 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4
6 Partial Oral Treatment of Endocarditis Unknown status NCT01375257 Phase 4
7 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4
8 Propofol Effects on Mitral Valve Annular Velocity Completed NCT01826149 Phase 4
9 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4
10 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
11 The Effects of Levosimendan During Mitral Valve Surgery Completed NCT01969071 Phase 4
12 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4
13 Cardiac Valve Complications in Prolactinomas Treated With Cabergoline Completed NCT00460616 Phase 4
14 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
15 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
16 Clinical Evaluation on Advanced Resynchronization Completed NCT00658203 Phase 4
17 Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair Completed NCT01144039 Phase 4
18 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4
19 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4
20 General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function Recruiting NCT03013075 Phase 4
21 Surgical Treatment of Ischemic Mitral Regurgitation Recruiting NCT01368575 Phase 4
22 (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) Recruiting NCT02592889 Phase 4
23 PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension Recruiting NCT02378649 Phase 4
24 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4
25 Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery Recruiting NCT02546765 Phase 4
26 Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral Stenosis Active, not recruiting NCT01406353 Phase 4
27 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation Active, not recruiting NCT02687932 Phase 4
28 Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease Not yet recruiting NCT02982850 Phase 4
29 Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery Not yet recruiting NCT02644980 Phase 4
30 High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy Terminated NCT02534155 Phase 4
31 Very Low Dose Oral Anticoagulation and Thromboembolic and Bleeding Complications Terminated NCT00528671 Phase 4
32 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
33 Efficiency of Radiofrequency Ablation for Surgical Treatment of Chronic Atrial Fibrillation With Rheumatic Valve Disease Unknown status NCT01013688 Phase 3
34 Predictors of Postoperative Left Ventricular Function in Patients Undergoing Mitral Valve Repair for Severe Degenerative Mitral Regurgitation Unknown status NCT01519050 Phase 3
35 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
36 Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular Unknown status NCT00659451 Phase 3
37 Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation Unknown status NCT00691470 Phase 2, Phase 3
38 Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
39 Randomised Ischaemic Mitral Evaluation (RIME) Trial Completed NCT00413998 Phase 3
40 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) Completed NCT01052428 Phase 2, Phase 3
41 Effect of Ivabradine on Heart Rate & Effort Tolerance in Mitral Stenosis in Sinus Rhythm Completed NCT01022463 Phase 3
42 Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients Completed NCT01621971 Phase 3
43 Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass Completed NCT02025621 Phase 3
44 Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation Completed NCT02132767 Phase 3
45 Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation Recruiting NCT01920698 Phase 3
46 Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) Recruiting NCT01626079 Phase 3
47 Cingularbio® Heart Valve Clincial Study Recruiting NCT02755220 Phase 3
48 Vitamin K1 to Slow Progression of Vascular Calcification in HD Patients Recruiting NCT01742273 Phase 3
49 Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial) Active, not recruiting NCT02435303 Phase 2, Phase 3
50 Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart Failure Suspended NCT00815386 Phase 2, Phase 3

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

Genetic tests related to Mitral Valve Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 29

Anatomical Context for Mitral Valve Disease

MalaCards organs/tissues related to Mitral Valve Disease:

39
Heart, Lung, Endothelial, Testes, Brain, Smooth Muscle, Kidney

Publications for Mitral Valve Disease

Articles related to Mitral Valve Disease:

(show top 50) (show all 621)
id Title Authors Year
1
Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration. ( 28132441 )
2017
2
Serum proteomic profiles in CKCS with Mitral valve disease. ( 28173805 )
2017
3
Mitral valve morphology assessed by three-dimensional transthoracic echocardiography in healthy dogs and dogs with myxomatous mitral valve disease. ( 28279678 )
2017
4
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
5
Erratum to degenerative mitral valve disease-contemporary surgical approaches and repair techniques. ( 28447012 )
2017
6
Exercise Testing and Stress Imaging in Mitral Valve Disease. ( 28290006 )
2017
7
Should pre-operative left atrial volume receive more consideration in patients with degenerative mitral valve disease undergoing mitral valve surgery? ( 27855288 )
2017
8
Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease. ( 28478943 )
2017
9
Real-Time 3-Dimensional Echocardiographic Assessment of Effective Regurgitant Orifice Area in Dogs With Myxomatous Mitral Valve Disease. ( 28109120 )
2017
10
Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease. ( 28111138 )
2017
11
Correlation between serum homocysteine concentration and severity of mitral valve disease in dogs. ( 28345991 )
2017
12
Pulmonary hypertension and mitral valve disease: Still a beast. ( 28411749 )
2017
13
Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease. ( 28380134 )
2017
14
Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays. ( 28449360 )
2017
15
Degenerative mitral valve disease-contemporary surgical approaches and repair techniques. ( 28203540 )
2017
16
Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease. ( 28453968 )
2017
17
A retrospective study of degenerative mitral valve disease in small-breed dogs: Survival and prognostic variables. ( 28057898 )
2017
18
Assessment of Left Atrial Deformation and Function by 2-Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease. ( 28455877 )
2017
19
Complex robotic correction for complex degenerative mitral valve disease. ( 28203546 )
2017
20
Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs. ( 28145607 )
2017
21
Differences in atrial fibrillationa89associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis. ( 27667121 )
2016
22
Comparison of outcomes of tricuspid annuloplasty with 3D-rigid versus flexible prosthetic ring for functional tricuspid regurgitation secondary to rheumatic mitral valve disease. ( 28066587 )
2016
23
Pulmonary vascular remodeling in mitral valve disease: An optical coherence tomography study. ( 26580335 )
2016
24
Galectin-3 in cardiac muscle and circulation of dogs with degenerative mitral valve disease. ( 26786977 )
2016
25
Valve Replacement with a Sutureless Aortic Prosthesis in a Patient with Concomitant Mitral Valve Disease and Severe Aortic Root Calcification. ( 27127442 )
2016
26
Mitraclip Followed by Surgical Aortic Valve Replacement: Hybrid Techniques for Regurgitant Aortic and Mitral Valve Disease. ( 27449464 )
2016
27
The immunohistochemical evaluation of selected markers in the left atrium of dogs with end-stage dilated cardiomyopathy and myxomatous mitral valve disease - a preliminary study. ( 27980728 )
2016
28
Case images: Left atrial appendage ostial stenosis in a patient with rheumatic mitral valve disease. ( 27665342 )
2016
29
Rheumatic Mitral Valve Disease Is Associated With Worse Outcomes in Stroke: A Thailand National Database Study. ( 27703088 )
2016
30
Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: a 4.8-year prospective cohort study. ( 27288746 )
2016
31
Reply: Limitations of Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification: Should it Be Performed Outside the Purview of a Clinical Trial? ( 27931601 )
2016
32
Treatment of Chronic Atrial Fibrillation During Surgery for Rheumatic Mitral Valve Disease. ( 27849305 )
2016
33
Aortic and Mitral Valve Disease and Left Ventricular Dysfunction in Children. ( 27490591 )
2016
34
Transcatheter valve implantation for calcific mitral valve disease. ( 26919347 )
2016
35
Extended neochord weaving technique for degenerative mitral valve disease. ( 27649998 )
2016
36
A comparison of the histopathologic pattern of the left atrium in canine dilated cardiomyopathy and chronic mitral valve disease. ( 26728624 )
2016
37
Preliminary Investigation of Cardiovascular-Renal Disorders in Dogs with Chronic Mitral Valve Disease. ( 27717188 )
2016
38
Effects of pimobendan on myocardial perfusion and pulmonary transit time in dogs with myxomatous mitral valve disease: a pilot study. ( 27569835 )
2016
39
Left atrial volume and function in dogs with naturally occurring myxomatous mitral valve disease. ( 27825670 )
2016
40
Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial. ( 27678080 )
2016
41
Surgery for rheumatic mitral valve disease in sub-saharan African countries: why valve repair is still the best surgical option. ( 28154662 )
2016
42
Results of a single-stage hybrid procedure for patients with coronary and mitral valve disease. ( 26922294 )
2016
43
LA thrombus formation in mitral valve disease. ( 28005019 )
2016
44
Limitations of Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification: Should it Be Performed Outside the Purview of a Clinical Trial? ( 27931600 )
2016
45
The Burden of Pulmonary Hypertension in Patients with Degenerative Mitral Valve Disease in Enugu South-East Nigeria: An Echocardiographic Based Study. ( 27398249 )
2016
46
Balloon expandable transcatheter heart valves for native mitral valve disease with severe mitral annular calcification. ( 27094423 )
2016
47
Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds. ( 28092620 )
2016
48
Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. ( 26831162 )
2016
49
Transcatheter mitral valve implantation for inoperable severely calcified native mitral valve disease: A systematic review. ( 26577250 )
2016
50
Is minimally invasive thoracoscopic surgery the new benchmark for treating mitral valve disease? ( 27942489 )
2016

Variations for Mitral Valve Disease

Expression for Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for Mitral Valve Disease

Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 AKT1 CXCR4 FBN1 MMP1 MMP13 PTK2
2
Show member pathways
12.79 ACE AGT AGTR1 AKT1 PTK2 TGFB2
3
Show member pathways
12.58 ADAM17 FBN1 MMP1 MMP13 TGFB2
4
Show member pathways
12.56 AGT AGTR1 AKT1 CXCR4 NOS3 PTK2
5
Show member pathways
12.31 AKT1 NPPA NPPB TGFB2
6
Show member pathways
12.3 AGTR1 AKT1 IL10 NOS3 PTK2
7
Show member pathways
11.91 AGT AKT1 NPPA NPPB
8 11.77 AKT1 NOS3 NPPA
9
Show member pathways
11.76 ADAM17 MMP1 MMP13
10 11.73 IL10 PTK2 TGFB2
11 11.7 AKT1 NOS3 PTK2
12 11.7 AGTR1 AKT1 CXCR4 MMP1 PTK2 TGFB2
13
Show member pathways
11.64 AKT1 NOS3 PTK2
14 11.59 AKT1 CXCR4 PTK2
15 11.55 AGTR1 AKT1 NOS3 TGFB2
16 11.51 AGTR1 CXCR4 IL10
17 11.49 AKT1 MMP13 NOS3
18 11.47 AKT1 MMP13 TGFB2
19 11.45 ACE AGT AGTR1
20
Show member pathways
11.16 ACE AGT AGTR1 NOS3
21 10.71 AKT1 NOS3 PTK2

GO Terms for Mitral Valve Disease

Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACE AGT FBN1 IL10 MMP1 MMP13
2 extracellular space GO:0005615 9.23 ACE AGT FBN1 IL10 MMP13 NPPA

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.91 FBN1 MMP1 MMP13 NPPA
2 response to organic substance GO:0010033 9.84 AKT1 IL10 SLC6A4
3 positive regulation of cell growth GO:0030307 9.82 ADAM17 AKT1 TGFB2
4 extracellular matrix disassembly GO:0022617 9.82 FBN1 MMP1 MMP13
5 cellular response to mechanical stimulus GO:0071260 9.81 AGT AKT1 NPPA
6 negative regulation of cell growth GO:0030308 9.81 AGT NPPA NPPB TGFB2
7 response to hypoxia GO:0001666 9.8 ADAM17 CXCR4 NPPA SLC6A4 TGFB2
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 AGT PTK2 TGFB2
9 positive regulation of cell cycle GO:0045787 9.72 IL10 SLC6A4 TGFB2
10 kidney development GO:0001822 9.72 ACE AGT AGTR1 FBN1 TGFB2
11 cell adhesion mediated by integrin GO:0033627 9.68 ADAM17 FBN1
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.67 AGT IL10
13 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.67 AGT AGTR1
14 low-density lipoprotein particle remodeling GO:0034374 9.66 AGT AGTR1
15 positive regulation of renal sodium excretion GO:0035815 9.66 AGT NPPB
16 nitric oxide biosynthetic process GO:0006809 9.65 AKT1 NOS3
17 angiotensin maturation GO:0002003 9.65 ACE AGT
18 regulation of vasoconstriction GO:0019229 9.65 ACE AGT AGTR1
19 neutrophil mediated immunity GO:0002446 9.63 ACE ADAM17
20 receptor guanylyl cyclase signaling pathway GO:0007168 9.63 NPPA NPPB
21 positive regulation of cellular protein metabolic process GO:0032270 9.63 AGT AGTR1 AKT1
22 negative regulation of organ growth GO:0046621 9.62 PTK2 SLC6A4
23 positive regulation of cholesterol esterification GO:0010873 9.62 AGT AGTR1
24 response to fluid shear stress GO:0034405 9.61 AKT1 NOS3
25 regulation of vasodilation GO:0042312 9.61 ACE AGTR1 NPPB
26 cell growth involved in cardiac muscle cell development GO:0061049 9.6 AGT NPPA
27 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.58 ADAM17 AKT1
28 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGT AGTR1
29 renin-angiotensin regulation of aldosterone production GO:0002018 9.57 AGT AGTR1
30 regulation of renal sodium excretion GO:0035813 9.56 AGT AGTR1
31 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.54 AGT AGTR1
32 regulation of blood vessel diameter GO:0097746 9.54 ACE AGTR1 NPPB
33 regulation of complement-dependent cytotoxicity GO:1903659 9.52 IL10 TGFB2
34 regulation of renal output by angiotensin GO:0002019 9.49 ACE AGT
35 blood vessel remodeling GO:0001974 9.46 ACE AGT NOS3 TGFB2
36 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGT AGTR1
37 regulation of blood pressure GO:0008217 9.35 ACE AGT NOS3 NPPA NPPB
38 regulation of blood vessel size GO:0050880 8.92 AGT NOS3 NPPA NPPB

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.46 ACE ADAM17 MMP1 MMP13
2 hormone activity GO:0005179 9.26 AGT FBN1 NPPA NPPB
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Mitral Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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