MCID: MTR012
MIFTS: 52

Mitral Valve Disease malady

Cardiovascular diseases category

Aliases & Classifications for Mitral Valve Disease

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 10DISEASES, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Aliases & Descriptions for Mitral Valve Disease:

Name: Mitral Valve Disease 8 44
Rheumatic Mitral Valve Incompetence 8 10
Rheumatic Disease of Mitral Valve 8 61
Chronic Rheumatic Mitral Valve 8 61
Rheumatic Mitral Valve Regurgitation 8
Rheumatic Mitral Valve Changes 8
 
Rheumatic Mitral Insufficiency 8
Rheumatic Mitral Regurgitation 61
Diseases of Mitral Valve 61
Disease of Mitral Valve 8
Mitral Rh Valve Dis. 8


Classifications:



Summaries for Mitral Valve Disease

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MalaCards based summary: Mitral Valve Disease, also known as rheumatic mitral valve incompetence, is related to atrial fibrillation and mitral valve stenosis. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are S1P3 pathway and amb2 Integrin signaling. The compounds aliskiren and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related mouse phenotypes are adipose tissue and respiratory system.

Related Diseases for Mitral Valve Disease

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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1atrial fibrillation31.3AGTR1, NPPA, ACE, SELP
2mitral valve stenosis31.0NPPA, SELP
3orthostatic intolerance30.9AGTR1
4pulmonary hypertension30.8AGT, NPPA, TPH1, NOS3
5congestive heart failure30.7AGTR1, AGT, NPPA, ACE
6arteriosclerosis30.6NOS3
7nephrotic syndrome30.1AGT, NPPA, ACE
8coronary artery disease29.9SELP, AGTR1, AGT, NOS3, ACE
9ischemia29.5TGFB2, NOS3, AKT1, SELP, AGT
10sick sinus syndrome10.5NPPA
11hepatorenal syndrome10.5NPPA
12gitelman syndrome10.5AGT
13proliferative glomerulonephritis10.4SELP
14artery disease10.4
15cor pulmonale10.4NPPA, AGTR1
16renal tubular dysgenesis10.3AGT, AGTR1
17marfan syndrome10.3
18endocarditis10.3
19aneurysm10.3
20endotheliitis10.3
21conn's syndrome10.3NPPA, AGTR1
22muscle hypertrophy10.3
23aortic valve disease 210.3NPPA, AGT
24vesicoureteral reflux10.3AGTR1, AGT
25dilated cardiomyopathy10.2
26dysphagia10.2
27blindness10.2
28vascular disease10.2SELP, AKT1
29portal hypertension10.2NOS3, AGTR1
30idiopathic edema10.1ACE, NPPA
31nephrosclerosis10.1AGTR1, ACE
32pure autonomic failure10.1ACE, NPPA
33renal fibrosis10.1AGT, TGFB2, AGTR1
34systemic lupus erythematosus10.1
35migraine10.1
36mucopolysaccharidosis vii10.1
37end stage renal failure10.1
38ischemic heart disease10.1
39splenic abscess10.1
40polyarteritis nodosa10.1
41hyperlucent lung10.1
42pulmonary edema10.1
43cerebritis10.1
44thoracic aortic aneurysm10.1
45aortic aneurysm10.1
46infective endocarditis10.1
47intracranial aneurysm10.1
48lupus erythematosus10.1
49mucopolysaccharidosis10.1
50respiratory failure10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Symptoms for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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MalaCards organs/tissues related to Mitral Valve Disease:

31
Heart, Lung, Endothelial, Brain, Smooth muscle, Testes, Kidney, Skin

Animal Models for Mitral Valve Disease or affiliated genes

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Publications for Mitral Valve Disease

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Articles related to Mitral Valve Disease:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Development of atrial fibrillation in patients with rheumatic mitral valve disease in sinus rhythm. (25665684)
2015
2
Systolic cardiac function assessment by feature tracking echocardiography in dogs with myxomatous mitral valve disease. (25833040)
2015
3
Left atrial rupture secondary to myxomatous mitral valve disease in 11 dogs. (25251426)
2014
4
Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation. (25115553)
2014
5
Echocardiography in mitral valve disease. Preface. (23743080)
2013
6
The role of exercise echocardiography in the management of mitral valve disease. (23959848)
2013
7
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
8
Heritability of premature mitral valve disease in Cavalier King Charles spaniels. (20347358)
2011
9
Holter monitoring in 36 dogs with myxomatous mitral valve disease. (20854294)
2010
10
Molecular changes in fibrillar collagen in myxomatous mitral valve disease. (19632135)
2010
11
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography. (21143934)
2010
12
Functional tricuspid regurgitation in mitral valve disease: epidemiology and prognostic implications. (20813320)
2010
13
Re: Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. (21054535)
2010
14
Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. (21036114)
2010
15
Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs. (19324577)
2010
16
Acquired atrial septal defects secondary to rupture of the atrial septum in dogs with degenerative mitral valve disease. (20584637)
2010
17
Percutaneous surgery for mitral valve disease. (19875371)
2009
18
Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease. (19143935)
2009
19
Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: A retrospective study of 141 cases. (19737176)
2009
20
Principles of reconstructive surgery in degenerative mitral valve disease. (17870003)
2007
21
Indications for surgery in degenerative mitral valve disease. (17870002)
2007
22
Giant left atrium secondary to rheumatic mitral valve disease. (16849894)
2006
23
Surgical treatment of atrial fibrillation through isolation of the left atrial posterior wall in patients with chronic rheumatic mitral valve disease. A randomized study with control group. (15375469)
2004
24
Tissue Doppler properties of the left atrial appendage in patients with mitral valve disease. (15104544)
2004
25
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
26
The Quattro valve in rheumatic mitral valve disease: four-year follow up. (14658818)
2003
27
Location, size, and morphologic characteristics of left atrial thrombi as assessed by transesophageal echocardiography in relation to systemic embolism in patients with rheumatic mitral valve disease. (12633822)
2003
28
Encircling isolation of pulmonary vein orifice for elimination of persistent atrial fibrillation associated with mitral valve disease. (12974929)
2003
29
Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease. (12056726)
2002
30
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
31
Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. (11420162)
2001
32
Surgical repair of the prolapsing anterior leaflet in degenerative mitral valve disease. (10678378)
2000
33
Surgery for mitral valve disease in the pediatric age group. (10384192)
1999
34
The Cox-Maze III procedure for atrial fibrillation associated with rheumatic mitral valve disease. (10509965)
1999
35
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
36
Repair of chordae tendineae for rheumatic mitral valve disease. A twenty-year experience. (8551768)
1996
37
Left atrial performance indices in chronic mitral valve disease. (8564003)
1995
38
The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. (8043061)
1994
39
Combined warfarin and antiplatelet therapy after St. Jude Medical valve replacement for mitral valve disease. (8113551)
1994
40
Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease. (8174568)
1994
41
Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. (15636941)
1994
42
Significance of left atrial spontaneous echo contrast in rheumatic mitral valve disease as a predictor of systemic arterial embolization: a transesophageal echocardiographic study. (8154427)
1994
43
Diagnosis of left atrial thrombi in mitral valve disease by coronary arteriography. (1699665)
1990
44
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
45
Echocardiography in mitral valve disease: a review. (3916435)
1985
46
Mitral valve disease and dysphagia. (6241564)
1984
47
Conservative surgery for mitral valve disease: clinical and echocardiographic analysis of results. (6612646)
1983
48
Right Ventricular function in aortic and mitral valve disease. (7226931)
1981
49
Pulmonary edema after ritodrine infusion for premature labor in a patient with mitral valve disease. (7211242)
1981
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.5AKT1, CXCR4
29.5SELP, AKT1
39.5TGFB2, SELP
49.4TGFB2, AKT1
59.3NOS3, AKT1
69.3AKT1, NOS3
7
Show member pathways
9.3AKT1, NOS3
8
Show member pathways
Angiogenesis36
9.3AKT1, NOS3
99.3AKT1, AGT, NPPA
10
Show member pathways
9.1TGFB2, AKT1, NPPA
11
Show member pathways
9.1TGFB2, AGT, AKT1
129.0AKT1, NPPA, NOS3
13
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.0AGTR1, NOS3, AKT1
14
Show member pathways
8.9NOS3, AKT1, CXCR4
15
Show member pathways
8.8NOS3, TGFB2, AKT1
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6ACE, TGFB2, AKT1
17
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
8.6AGTR1, NOS3, AKT1, CXCR4
18
Show member pathways
8.4CXCR4, NOS3, AKT1, TGFB2
19
Show member pathways
8.4NOS3, CXCR4, TGFB2, AKT1
20
Show member pathways
8.4TGFB2, SELP, NOS3, AKT1
21
Show member pathways
8.3AGTR1, ACE, NOS3, AGT
22
Show member pathways
8.3AGTR1, AKT1, AGT, CXCR4, TGFB2
23
Show member pathways
7.9TGFB2, AKT1, AGT, ACE, AGTR1

Compounds for genes affiliated with Mitral Valve Disease

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Compounds related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1aliskiren44 1110.3AGTR1, AGT, ACE
2cilazapril44 1110.3ACE, AGTR1, NPPA
3trandolapril44 1110.3ACE, NPPA, AGTR1
4saralasin449.2AGTR1, ACE, AGT
5eprosartan44 28 1111.2AGT, ACE, AGTR1
6pd12331944 2810.2ACE, AGTR1, AGT
7fosinopril44 1110.1AGTR1, NPPA, ACE
8olmesartan44 28 1111.1AGTR1, ACE, AGT
9benazepril44 50 1111.1AGT, AGTR1, ACE, NPPA
10lisinopril44 50 24 1112.0NPPA, ACE, AGT, AGTR1
11enalapril44 50 1111.0AGTR1, ACE, NPPA, AGT
12quinapril44 50 1111.0SELP, AGTR1, ACE, NPPA
13captopril44 60 50 28 1113.0AGT, NPPA, ACE, AGTR1
14isosorbide dinitrate44 50 1110.9ACE, NPPA, NOS3
15enalaprilat448.9AGT, ACE, NPPA
16valsartan44 60 28 1111.9AGT, SELP, ACE, AGTR1
17prostaglandin448.9TGFB2, CXCR4, AGT, AGTR1, NPPA
18sele448.8SELP, ACE, AGT
19sodium nitroprusside448.8NPPA, SELP, TPH1, AGTR1, NOS3
20carvedilol44 50 28 1111.8AGTR1, ACE, NOS3, NPPA
21l-nmma448.7AKT1, AGTR1, AGT, NPPA, NOS3
22phenylephrine44 28 24 1111.7NOS3, NPPA, AGT, AGTR1, AKT1
23simvastatin44 50 60 28 24 1113.5AGTR1, SELP, NOS3, AKT1, AGT
24fluvastatin44 50 28 1111.5AGTR1, NOS3, ACE, SELP
25n acetylcysteine448.5AGTR1, AGT, SELP, TGFB2, AKT1
26epinephrine44 24 1110.5AGTR1, NPPA, SELP, AKT1, CXCR4, AGT
27perindopril44 50 1110.5NPPA, NOS3, ACE, AGTR1, AGT
28amlodipine44 50 24 1111.5AGT, AGTR1, NPPA, NOS3, ACE
29ang ii448.4AGTR1, ACE, NOS3, AGT, NPPA
30dopamine44 28 24 1111.4TPH1, TGFB2, AKT1, NPPA, AGTR1, AGT
31cyclosporin a44 28 6010.4SELP, AGT, CXCR4, NPPA, TGFB2, AGTR1
32sb 20358044 609.4AGTR1, NOS3, CXCR4, AKT1, AGT
33nitroglycerin44 119.4NOS3, AGTR1, NPPA, ACE, SELP
34candesartan44 50 28 1111.3AGTR1, NOS3, ACE, SELP, AGT
35norepinephrine44 24 1110.3ACE, TPH1, AGTR1, SELP, NPPA, AGT
36pge2448.2TGFB2, AGT, NPPA, CXCR4, AKT1, SELP
37aspirin44 50 28 2411.1NOS3, ACE, CXCR4, SELP, AGTR1
38losartan44 50 28 1111.1AGT, SELP, AKT1, ACE, NPPA, AGTR1
39atorvastatin44 50 28 24 1112.1SELP, AKT1, ACE, NOS3, AGT
40genistein44 28 60 1 24 1113.0AGTR1, AKT1, SELP, AGT, NOS3, TGFB2
41pravastatin44 50 28 24 1111.9SELP, ACE, NOS3, AGTR1
42acetylcholine44 50 28 24 1111.9TPH1, AKT1, ACE, NOS3, AGTR1, AGT
43dexamethasone44 50 28 1110.8AGT, AGTR1, SELP, TGFB2, CXCR4, AKT1
44arginine447.6NOS3, AGTR1, AGT, TPH1, NPPA, SELP
45creatinine447.6AGT, NPPA, ACE, AKT1, TGFB2, SELP
46prostacyclin447.5SELP, AKT1, ACE, NOS3, NPPA, AGT
47estrogen447.4TPH1, TGFB2, SELP, AGTR1, NOS3, NPPA
48vegf447.4AGT, NPPA, NOS3, CXCR4, AKT1, SELP
49calcium44 50 24 119.8TGFB2, ACE, AGTR1, AGT, NPPA, NOS3
50nitric oxide44 24 118.8TGFB2, CXCR4, TPH1, AGTR1, AGT, NPPA

GO Terms for genes affiliated with Mitral Valve Disease

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Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5SELP, CXCR4, ACE
2extracellular spaceGO:00056157.9AGT, NPPA, ACE, SELP, TGFB2
3plasma membraneGO:00058867.3AGTR1, NOS3, ACE, CXCR4, AKT1, SELP

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.2AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:000203410.1AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, AGTR1
4regulation of renal sodium excretionGO:003581310.1AGT, AGTR1
5positive regulation of cholesterol esterificationGO:001087310.1AGT, AGTR1
6low-density lipoprotein particle remodelingGO:003437410.1AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:020003799.9AGTR1, AGT
9regulation of blood vessel sizeGO:00508809.8NOS3, NPPA
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8AGT, AGTR1
11positive regulation of inflammatory responseGO:00507299.8AGTR1, AGT
12nitric oxide mediated signal transductionGO:00072639.7NOS3, AGT
13response to fluid shear stressGO:00344059.7AKT1, NOS3
14regulation of renal output by angiotensinGO:00020199.7ACE, AGT
15regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.7AGTR1, ACE
16germ cell developmentGO:00072819.7CXCR4, AKT1
17cellular response to mechanical stimulusGO:00712609.7AKT1, AGT, NPPA
18positive regulation of cellular protein metabolic processGO:00322709.6AGTR1, AGT, AKT1
19regulation of vasodilationGO:00423129.6ACE, AGTR1
20nitric oxide biosynthetic processGO:00068099.6NOS3, AKT1
21negative regulation of cell growthGO:00303089.6TGFB2, AGT, NPPA
22angiotensin maturationGO:00020039.6AGT, ACE
23regulation of nitric-oxide synthase activityGO:00509999.6AKT1, NOS3
24nitric oxide metabolic processGO:00462099.5NOS3, AKT1
25positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5SELP, TGFB2, AGT
26response to hypoxiaGO:00016669.5NPPA, CXCR4, TGFB2
27calcium-mediated signalingGO:00197229.4AGTR1, CXCR4
28regulation of vasoconstrictionGO:00192299.3AGTR1, ACE, AGT
29response to heatGO:00094089.3AKT1, NOS3
30kidney developmentGO:00018229.3AGTR1, AGT, ACE
31G-protein coupled receptor signaling pathwayGO:00071869.2AGTR1, AKT1, AGT, CXCR4
32platelet activationGO:00301689.2TGFB2, SELP, AKT1
33regulation of blood pressureGO:00082179.1ACE, NOS3, NPPA
34inflammatory responseGO:00069549.0SELP, AKT1, CXCR4
35blood coagulationGO:00075968.7TGFB2, NOS3, AKT1, SELP
36blood vessel remodelingGO:00019748.5ACE, TGFB2, NOS3, AGT

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:00317119.0AGTR1, ACE
2protein bindingGO:00055156.4SELP, AKT1, CXCR4, ACE, NOS3, AGT

Sources for Mitral Valve Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet