MCID: MTR012
MIFTS: 59

Mitral Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Disease

MalaCards integrated aliases for Mitral Valve Disease:

Name: Mitral Valve Disease 12 51 14
Chronic Rheumatic Mitral Valve 12 69
Rheumatic Mitral Valve Regurgitation 12
Rheumatic Mitral Valve Incompetence 12
Rheumatic Disease of Mitral Valve 12
Abnormality of the Mitral Valve 28
Rheumatic Mitral Insufficiency 12
Rheumatic Mitral Valve Changes 12
Rheumatic Mitral Regurgitation 69
Diseases of Mitral Valve 69
Disease of Mitral Valve 12
Mitral Rh Valve Dis. 12

Classifications:



Summaries for Mitral Valve Disease

MalaCards based summary : Mitral Valve Disease, also known as chronic rheumatic mitral valve, is related to orthostatic intolerance and atrial fibrillation. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Metoprolol and Morphine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Mitral Valve Disease

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 32.4 AGTR1 FBN1 NOS3
2 atrial fibrillation 31.3 ACE AGT AGTR1 NPPA
3 coronary artery anomaly 30.2 ACE AGTR1 NOS3 NPPA
4 pulmonary hypertension 30.2 ACE NOS3 NPPA SLC6A4 TPH1
5 arteries, anomalies of 30.1 ACE AGT AGTR1 NOS3
6 aortic aneurysm, familial thoracic 1 30.1 FBN1 MMP1 TGFB2
7 end stage renal failure 30.0 ACE AGT AGTR1
8 pulmonary edema 29.8 ACE IL10 NOS3
9 hyperlucent lung 29.8 IL10 IL4
10 heart disease 29.6 ACE AGTR1 FBN1 NOS3 NPPA TGFB3
11 aortic aneurysm 29.6 FBN1 MMP13 TGFB2
12 rheumatic heart disease 29.6 ACE IL10 IL4
13 stroke, ischemic 29.5 ACE AGTR1 AKT1 FBN1 NOS3
14 aortic coarctation 29.5 ACE AGT AGTR1 FBN1 NOS3
15 hypertension, essential 29.4 ACE AGT AGTR1 NOS3 NPPA
16 dilated cardiomyopathy 28.3 ACE AGT AGTR1 IL10 IL4 MMP1
17 cardiac valvular dysplasia, x-linked 11.4
18 mitral valve stenosis 11.4
19 loeys-dietz syndrome 5 11.2
20 loeys-dietz syndrome 4 10.5 TGFB2 TGFB3
21 pediatric hypertension 10.5 ACE AGT
22 adrenal gland pheochromocytoma 10.4 AKT1 NOS3
23 mitral valve insufficiency 10.4 ACE FBN1 NPPA
24 anterolateral myocardial infarction 10.4 ACE NPPA
25 loeys-dietz syndrome 10.4 FBN1 TGFB2 TGFB3
26 hypoaldosteronism 10.4 ACE NPPA
27 posterior urethral valves 10.4 ACE AGT AGTR1
28 anuria 10.4 ACE AGT AGTR1
29 familial hypertension 10.4 AGT AGTR1 NPPA
30 fibromuscular dysplasia 10.4 ACE AGT AGTR1
31 oligohydramnios 10.4 ACE AGT AGTR1
32 renal tubular dysgenesis 10.4 ACE AGT AGTR1
33 tuberculoid leprosy 10.3 IL10 TGFB2 TGFB3
34 renal dysplasia 10.3 ACE AGT AGTR1
35 chronic actinic dermatitis 10.3 FBN1 MMP1
36 vasculogenic impotence 10.3 ACE NOS3 NPPA
37 congestive heart failure 10.3
38 acute mountain sickness 10.3 ACE AGTR1 NOS3
39 otosclerosis 10.3 ACE AGT AGTR1
40 nonarteritic anterior ischemic optic neuropathy 10.3 ACE AGTR1 NOS3
41 inguinal hernia 10.2 FBN1 MMP1 MMP13
42 malignant hypertension 10.2 ACE AGT AGTR1 NPPA
43 aortic valve disease 2 10.2 ACE AGT FBN1 NPPA
44 hypertensive heart disease 10.2 ACE AGT AGTR1 MMP1
45 glucose metabolism disease 10.2 ACE AKT1 NOS3
46 fibrosis of extraocular muscles, congenital, 1 10.2
47 irritable bowel syndrome 10.2 IL10 SLC6A4 TPH1
48 tropical endomyocardial fibrosis 10.2 IL10 IL4
49 renal artery disease 10.1 ACE AGTR1 NOS3 NPPA
50 renovascular hypertension 10.1 ACE AGTR1 NOS3 NPPA

Comorbidity relations with Mitral Valve Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 86)


Accessory Nerve Disease Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alcoholic Cardiomyopathy Anxiety
Aortic Atherosclerosis Aortic Valve Disease 1
Atrioventricular Block Basilar Artery Insufficiency
Benign Essential Hypertension Bronchiectasis
Bronchitis Cardiac Arrest
Cardiac Arrhythmia Cardiogenic Shock
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Constrictive Pericarditis
Coronary Artery Aneurysm Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Disseminated Intravascular Coagulation Dressler's Syndrome
Dyskinesia of Esophagus Dysthymic Disorder
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hepatitis
Hyperlipoproteinemia, Type Iv Hyperlipoproteinemia, Type V
Hypertension, Essential Hypertrophic Cardiomyopathy
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypothyroidism Idiopathic Interstitial Pneumonia
Intermediate Coronary Syndrome Intracranial Embolism

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to Mitral Valve Disease

Symptoms & Phenotypes for Mitral Valve Disease

MGI Mouse Phenotypes related to Mitral Valve Disease:

43 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.52 FBN1 CXCR4 AKT1 ADAM17 MMP13 AGT
2 homeostasis/metabolism MP:0005376 10.5 FBN1 CXCR4 AKT1 ADAM17 MMP13 AGT
3 growth/size/body region MP:0005378 10.48 FBN1 AGTR1 CXCR4 AKT1 MMP13 ADAM17
4 cellular MP:0005384 10.4 AKT1 FBN1 CXCR4 IL10 MMP13 ADAM17
5 immune system MP:0005387 10.39 FBN1 AGTR1 CXCR4 AKT1 ADAM17 AGT
6 hematopoietic system MP:0005397 10.38 FBN1 AGTR1 CXCR4 AKT1 ADAM17 IL4
7 behavior/neurological MP:0005386 10.34 AKT1 AGTR1 AGER IL10 AGT FBN1
8 endocrine/exocrine gland MP:0005379 10.3 AKT1 FBN1 CXCR4 IL10 ADAM17 IL4
9 mortality/aging MP:0010768 10.28 AKT1 AGTR1 CXCR4 IL10 AGT ADAM17
10 muscle MP:0005369 10.22 FBN1 CXCR4 AKT1 ADAM17 AGT NOS3
11 integument MP:0010771 10.19 AKT1 IL10 MMP13 ADAM17 FBN1 IL4
12 digestive/alimentary MP:0005381 10.18 CXCR4 IL10 ADAM17 IL4 PTK2 NOS3
13 nervous system MP:0003631 10.18 AKT1 FBN1 AGTR1 CXCR4 AGT ADAM17
14 embryo MP:0005380 10.17 AKT1 CXCR4 IL10 ADAM17 FBN1 PTK2
15 adipose tissue MP:0005375 10.15 AKT1 AGTR1 AGT FBN1 ACE NOS3
16 limbs/digits/tail MP:0005371 10.08 IL10 MMP13 ADAM17 FBN1 PTK2 NOS3
17 liver/biliary system MP:0005370 10 AKT1 IL10 AGT IL4 ACE PTK2
18 normal MP:0002873 9.97 AKT1 IL10 ADAM17 IL4 AGER SLC6A4
19 renal/urinary system MP:0005367 9.96 FBN1 AGTR1 CXCR4 AGT IL4 ACE
20 reproductive system MP:0005389 9.9 AKT1 FBN1 CXCR4 AGT ADAM17 IL4
21 respiratory system MP:0005388 9.7 FBN1 CXCR4 AKT1 ADAM17 IL4 IL10
22 skeleton MP:0005390 9.4 AKT1 FBN1 CXCR4 MMP13 ADAM17 IL4

Drugs & Therapeutics for Mitral Valve Disease

Drugs for Mitral Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8 Racepinephrine Approved Phase 4 329-65-7
9 Analgesics Phase 4,Phase 2
10 Central Nervous System Depressants Phase 4,Phase 2
11 Analgesics, Non-Narcotic Phase 4,Phase 2
12 Anesthetics Phase 4,Phase 2
13 Anesthetics, Local Phase 4,Phase 2
14 Peripheral Nervous System Agents Phase 4,Phase 2
15 Anti-Arrhythmia Agents Phase 4,Phase 2
16 Pharmaceutical Solutions Phase 4
17 Adrenergic Agents Phase 4
18 Adrenergic Antagonists Phase 4
19 Adrenergic beta-1 Receptor Antagonists Phase 4
20 Adrenergic beta-Antagonists Phase 4
21 Sympatholytics Phase 4
22 Neurotransmitter Agents Phase 4
23 Antihypertensive Agents Phase 4
24 Autonomic Agents Phase 4
25 Narcotics Phase 4
26 Analgesics, Opioid Phase 4
27 Anesthetics, General Phase 4
28 Antipyretics Phase 4
29 Carticaine Phase 4
30 Epinephryl borate Phase 4
31
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
32 Sildenafil Citrate Phase 2, Phase 3 171599-83-0
33 Vasodilator Agents Phase 2, Phase 3
34 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3
35 Phosphodiesterase Inhibitors Phase 2, Phase 3
36 Citrate Nutraceutical Phase 2, Phase 3
37
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
38
Ketorolac Approved Phase 2 74103-06-3, 66635-83-4 3826
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
40 Sodium Channel Blockers Phase 2
41 Cyclooxygenase Inhibitors Phase 2
42 Diuretics, Potassium Sparing Phase 2
43 Anti-Inflammatory Agents Phase 2
44 Anti-Inflammatory Agents, Non-Steroidal Phase 2
45 Ketorolac Tromethamine Phase 2
46 Antirheumatic Agents Phase 2
47 Plasma-lyte 148

Interventional clinical trials:

(show top 50) (show all 51)

# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
2 General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function Recruiting NCT03013075 Phase 4 Bupivacaine heavy and Morphine;General Anesthetics
3 Postoperative Analgesia After Minithoracotomy Recruiting NCT03415555 Phase 4 Oxycodone;paracetamol
4 Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Terminated NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
5 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
6 Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair Completed NCT00567853 Phase 3
7 Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial) Active, not recruiting NCT02435303 Phase 2, Phase 3 Sildenafil;Placebo
8 Preoperative Oral Immunonutrition and Cardiac Patients Not yet recruiting NCT03445221 Phase 2, Phase 3
9 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
10 Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery Completed NCT01481350 Phase 2 sildenafil
11 Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation Completed NCT00807040 Phase 2
12 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
13 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery Unknown status NCT02374229 Phase 1
14 St. Jude Medical Percutaneous Mitral Valve Repair Study Completed NCT01500148 Phase 1
15 Mitral Implantation of TRAnscatheter vaLves Recruiting NCT02370511 Phase 1
16 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
17 Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring Unknown status NCT01987635
18 Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5% Unknown status NCT01849757
19 Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease Completed NCT03278574
20 Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery Completed NCT01646541
21 The Effectiveness of Respiratory Physiotherapy in Mitral Valve Surgery Completed NCT02278835
22 Safety and Performance Study of the NeoChord Device Completed NCT01777815
23 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Completed NCT01246947
24 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262
25 Identifying an Ideal Cardiopulmonary Exercise Test Parameter Completed NCT01162083
26 Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR Completed NCT02371863
27 Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery Recruiting NCT02925819
28 A Modified Cox-Maze Operation for the Treatment of Permanent Atrial Fibrillation With Mitral Valve Disease Recruiting NCT03347695
29 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study Recruiting NCT03155373
30 PRESERVE-MITRAL Post-Market Registry Recruiting NCT03283722
31 Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach Recruiting NCT03195595
32 Annuloplasty for Not-Severe TR in Patient Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552
33 Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders Recruiting NCT03365453
34 Early Initiation of Post Sternotomy CArdiac Rehabilitation Recruiting NCT03223558
35 Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair Recruiting NCT02803957
36 STS/ACC TVT Registry Mitral Module Recruiting NCT02245763
37 MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery Recruiting NCT03012178
38 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Recruiting NCT02804321
39 PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients Recruiting NCT03438825
40 Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients Recruiting NCT03444259
41 Improving Mitral Repair for Functional Mitral Regurgitation Recruiting NCT03366649
42 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
43 HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve Active, not recruiting NCT02097420
44 Long Term Follow Up for CTSN Mitral Valve Repair Studies Enrolling by invitation NCT03066050
45 Mitral Annuloplasty Rings RCT Not yet recruiting NCT03290872
46 PARTNER 3 Trial - Mitral Valve in Valve Not yet recruiting NCT03193801
47 Prophylactic Pulmonary Vein Isolation Study Terminated NCT00587899
48 Artificial Valve Endocarditis Reduction Trial Terminated NCT00590889
49 The Dutch Asymptomatic Mitral Regurgitation Trial Terminated NCT01708265
50 Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry Terminated NCT01281397

Search NIH Clinical Center for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

Genetic tests related to Mitral Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Mitral Valve 28

Anatomical Context for Mitral Valve Disease

MalaCards organs/tissues related to Mitral Valve Disease:

38
Heart, Testes, Endothelial, Whole Blood, Lung, Brain, Smooth Muscle

Publications for Mitral Valve Disease

Articles related to Mitral Valve Disease:

(show top 50) (show all 655)
# Title Authors Year
1
Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease. ( 29420783 )
2018
2
Repair for rheumatic mitral valve disease. The controversy goes on! ( 29331985 )
2018
3
Long-term results of suture annuloplasty for degenerative mitral valve disease: a propensity-matched analysis. ( 29206693 )
2018
4
Regional Left Ventricular Myocardial Mechanics in Degenerative Myxomatous Mitral Valve Disease: A Comparison Between Fibroelastic Deficiency and Barlow's Disease. ( 29361488 )
2018
5
Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease. ( 29315310 )
2018
6
Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. ( 29214723 )
2018
7
Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease. ( 29200408 )
2018
8
Echocardiographic Estimates of Right Ventricular Systolic Function in Dogs with Myxomatous Mitral Valve Disease. ( 29224256 )
2018
9
Causes of repair failure for degenerative mitral valve disease and reoperation outcomes. ( 29309559 )
2018
10
Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration. ( 29428085 )
2018
11
Risk Factors of Recurrence of Atrial Fibrillation after AF Surgery in Patients with AF and Mitral Valve Disease. ( 29410135 )
2018
12
Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. ( 29390969 )
2018
13
Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs. ( 28145607 )
2017
14
Mitral valve repair for degenerative mitral valve disease: surgical approach, patient selection and long-term outcomes. ( 28566474 )
2017
15
Substrate characteristics and ablation outcome of left atrial tachycardia in rheumatic mitral valve disease. ( 28594430 )
2017
16
Exercise Testing and Stress Imaging in Mitral Valve Disease. ( 28290006 )
2017
17
Degenerative mitral valve disease-contemporary surgical approaches and repair techniques. ( 28203540 )
2017
18
Mid-term results of mitral valve repair using flexible bands versus complete rings in patients with degenerative mitral valve disease: a prospective, randomized study. ( 29237465 )
2017
19
Should high risk patients with concomitant severe aortic stenosis and mitral valve disease undergo double valve surgery in the TAVR era? ( 29284509 )
2017
20
Prof. Tohru Asai & Prof. Taweesak Chotivatanapong: treatment of mitral valve disease. ( 28890880 )
2017
21
Serum proteomic profiles in CKCS with Mitral valve disease. ( 28173805 )
2017
22
Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease. ( 28111138 )
2017
23
Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease. ( 28453968 )
2017
24
Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration. ( 28132441 )
2017
25
Polymorphisms in the serotonin transporter protein gene in Maltese dogs with degenerative mitral valve disease. ( 28693307 )
2017
26
Mitral Valve Disease: a Comprehensive Review. ( 28688022 )
2017
27
A retrospective study of degenerative mitral valve disease in small-breed dogs: Survival and prognostic variables. ( 28057898 )
2017
28
Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease. ( 28705792 )
2017
29
Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays. ( 28449360 )
2017
30
Complex robotic correction for complex degenerative mitral valve disease. ( 28203546 )
2017
31
Review of Diagnostic and Therapeutic Approach to Canine Myxomatous Mitral Valve Disease. ( 29056705 )
2017
32
Real-Time 3-Dimensional Echocardiographic Assessment of Effective Regurgitant Orifice Area in Dogs With Myxomatous Mitral Valve Disease. ( 28109120 )
2017
33
Two-dimensional echocardiographic estimates of left atrial function in healthy dogs and dogs with myxomatous mitral valve disease. ( 29111284 )
2017
34
Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model. ( 28804599 )
2017
35
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
36
Should pre-operative left atrial volume receive more consideration in patients with degenerative mitral valve disease undergoing mitral valve surgery? ( 27855288 )
2017
37
Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease. ( 28380134 )
2017
38
The Cox-Maze IV procedure for atrial fibrillation is equally efficacious in patients with rheumatic and degenerative mitral valve disease. ( 28583297 )
2017
39
Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease. ( 28478943 )
2017
40
Tricuspid annular plane systolic excursion in dogs with myxomatous mitral valve disease with and without pulmonary hypertension. ( 28579307 )
2017
41
Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging. ( 28540065 )
2017
42
Pulmonary hypertension and mitral valve disease: Still a beast. ( 28411749 )
2017
43
Diagnostic accuracy of electrocardiographic P wave related parameters in the assessment of left atrial size in dogs with degenerative mitral valve disease. ( 28845021 )
2017
44
Correlation between serum homocysteine concentration and severity of mitral valve disease in dogs. ( 28345991 )
2017
45
Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study. ( 28734620 )
2017
46
Surgical ablation for atrial fibrillation in mitral valve disease: impact of the maze procedure. ( 29240882 )
2017
47
Use of a Minimally Invasive Cardiac Output Monitor to Optimise Haemodynamics in a Patient with Mitral Valve Disease Undergoing Cerebrovascular Surgery. ( 29062560 )
2017
48
Cardiomyocyte marker expression in dogs with left atrial enlargement due to dilated cardiomyopathy or myxomatous mitral valve disease. ( 28612341 )
2017
49
Assessment of Left Atrial Deformation and Function by 2-Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease. ( 28455877 )
2017
50
Concomitant or Staged Transcatheter Treatment for Severe Combined Aortic and Mitral Valve Disease. ( 28579347 )
2017

Variations for Mitral Valve Disease

Expression for Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for Mitral Valve Disease

Pathways related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 ADAM17 AKT1 CXCR4 FBN1 IL10 IL4
2
Show member pathways
13.52 AGT AGTR1 AKT1 CXCR4 IL10 IL4
3
Show member pathways
13.38 AKT1 CXCR4 IL10 IL4 NOS3 PTK2
4
Show member pathways
13.3 AKT1 FBN1 MMP1 MMP13 PTK2 TGFB2
5
Show member pathways
13.27 AKT1 CXCR4 IL10 IL4 PTK2 TGFB2
6
Show member pathways
12.77 AGT AGTR1 AKT1 CXCR4 NOS3 PTK2
7
Show member pathways
12.66 ADAM17 FBN1 MMP1 MMP13 TGFB2 TGFB3
8
Show member pathways
12.64 ACE AGT AGTR1 AKT1 IL4 PTK2
9
Show member pathways
12.55 AGTR1 AKT1 IL10 NOS3 PTK2
10
Show member pathways
12.53 AKT1 MMP1 MMP13 NOS3 PTK2
11
Show member pathways
12.48 ACE AKT1 IL10 TGFB2 TGFB3
12
Show member pathways
12.45 AKT1 PTK2 TGFB2 TGFB3
13
Show member pathways
12.45 AKT1 NPPA TGFB2 TGFB3
14
Show member pathways
12.3 AKT1 IL4 MMP1 MMP13
15 12.28 AGTR1 AKT1 CXCR4 IL4 MMP1 PTK2
16 12.2 AKT1 IL10 TGFB2 TGFB3
17
Show member pathways
12.17 CXCR4 FBN1 MMP1 MMP13 PTK2
18 12.15 AKT1 MMP1 TGFB2 TGFB3
19
Show member pathways
12.07 AKT1 IL10 IL4 TGFB2 TGFB3
20
Show member pathways
12.04 AKT1 IL10 TGFB2 TGFB3
21 11.92 AKT1 IL10 IL4 MMP1
22 11.86 AKT1 TGFB2 TGFB3
23 11.84 AKT1 NOS3 PTK2
24
Show member pathways
11.83 IL4 TGFB2 TGFB3
25 11.82 MMP1 TGFB2 TGFB3
26 11.81 AGTR1 AKT1 CXCR4 IL10
27
Show member pathways
11.78 AKT1 NOS3 PTK2
28 11.78 IL10 PTK2 TGFB2 TGFB3
29 11.77 AKT1 IL4 MMP1
30 11.73 AKT1 CXCR4 PTK2
31 11.72 MMP13 NOS3 TGFB2 TGFB3
32
Show member pathways
11.71 FBN1 TGFB2 TGFB3
33
Show member pathways
11.66 ACE AGT AGTR1 NOS3
34 11.65 AKT1 MMP13 TGFB2
35 11.64 ACE AGT AGTR1
36 11.63 AKT1 IL10 IL4
37 11.56 ADAM17 AGER AKT1
38
Show member pathways
11.56 AKT1 PTK2 TGFB2 TGFB3
39 11.5 IL10 TGFB2 TGFB3
40 11.49 AGER AKT1 MMP13 NOS3
41 11.44 IL10 IL4 TGFB2 TGFB3
42 11.38 AKT1 PTK2 TGFB2 TGFB3
43
Show member pathways
11.32 IL10 TGFB2 TGFB3
44 11.2 AKT1 TGFB2 TGFB3
45 11.1 AGER AGTR1 AKT1 NOS3 TGFB2 TGFB3
46 11.07 AKT1 NOS3 PTK2
47 10.96 FBN1 IL10 IL4 PTK2 TGFB2 TGFB3
48 10.84 IL4 TGFB2 TGFB3
49 10.51 IL4 TGFB2 TGFB3

GO Terms for Mitral Valve Disease

Cellular components related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ACE AGT FBN1 IL10 IL4 MMP13
2 extracellular region GO:0005576 9.7 ACE AGER AGT FBN1 IL10 IL4
3 extracellular matrix GO:0031012 9.1 FBN1 MMP1 MMP13 NPPA TGFB2 TGFB3

Biological processes related to Mitral Valve Disease according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.95 FBN1 MMP1 MMP13 NPPA
2 aging GO:0007568 9.9 AGT AKT1 IL10 TGFB3
3 positive regulation of protein phosphorylation GO:0001934 9.89 ADAM17 AGER AKT1 PTK2
4 transforming growth factor beta receptor signaling pathway GO:0007179 9.87 PTK2 TGFB2 TGFB3
5 female pregnancy GO:0007565 9.86 AGT NPPA TGFB3
6 response to organic substance GO:0010033 9.86 AKT1 IL10 SLC6A4
7 positive regulation of cell growth GO:0030307 9.85 ADAM17 AKT1 TGFB2
8 extracellular matrix disassembly GO:0022617 9.84 FBN1 MMP1 MMP13
9 cellular response to mechanical stimulus GO:0071260 9.84 AGT AKT1 NPPA
10 B cell differentiation GO:0030183 9.81 ADAM17 IL10 IL4
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 AGT PTK2 TGFB2
12 regulation of receptor activity GO:0010469 9.8 AGT FBN1 IL10 IL4 NPPA TGFB2
13 epidermal growth factor receptor signaling pathway GO:0007173 9.79 ADAM17 AKT1 PTK2
14 positive regulation of cell cycle GO:0045787 9.72 IL10 SLC6A4 TGFB2
15 regulation of blood vessel diameter GO:0097746 9.69 ACE AGTR1
16 low-density lipoprotein particle remodeling GO:0034374 9.68 AGT AGTR1
17 nitric oxide biosynthetic process GO:0006809 9.68 AKT1 NOS3
18 angiotensin maturation GO:0002003 9.67 ACE AGT
19 blood vessel remodeling GO:0001974 9.67 ACE AGT NOS3
20 neutrophil mediated immunity GO:0002446 9.66 ACE ADAM17
21 salivary gland morphogenesis GO:0007435 9.65 TGFB2 TGFB3
22 negative regulation of organ growth GO:0046621 9.65 PTK2 SLC6A4
23 response to fluid shear stress GO:0034405 9.64 AKT1 NOS3
24 positive regulation of cholesterol esterification GO:0010873 9.64 AGT AGTR1
25 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.62 ADAM17 AKT1
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 IL4
27 regulation of blood pressure GO:0008217 9.62 ACE AGT NOS3 NPPA
28 type 2 immune response GO:0042092 9.61 IL10 IL4
29 regulation of vasoconstriction GO:0019229 9.61 ACE AGT AGTR1
30 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGT AGTR1
31 negative regulation of macrophage cytokine production GO:0010936 9.58 TGFB2 TGFB3
32 regulation of blood vessel size GO:0050880 9.58 AGT NOS3 NPPA
33 renin-angiotensin regulation of aldosterone production GO:0002018 9.57 AGT AGTR1
34 regulation of isotype switching GO:0045191 9.56 IL10 IL4
35 kidney development GO:0001822 9.55 ACE AGT AGTR1 FBN1 TGFB2
36 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.54 AGT AGTR1
37 positive regulation of cellular protein metabolic process GO:0032270 9.54 AGT AGTR1 AKT1
38 regulation of renal sodium excretion GO:0035813 9.52 AGT AGTR1
39 regulation of complement-dependent cytotoxicity GO:1903659 9.51 IL10 TGFB2
40 regulation of renal output by angiotensin GO:0002019 9.48 ACE AGT
41 uterine wall breakdown GO:0042704 9.46 TGFB2 TGFB3
42 response to hypoxia GO:0001666 9.17 ADAM17 AGER CXCR4 NPPA SLC6A4 TGFB2
43 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
44 positive regulation of cell proliferation GO:0008284 10.07 ADAM17 AGT AKT1 PTK2 TGFB2

Molecular functions related to Mitral Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 IL10 IL4 TGFB2 TGFB3
2 metallopeptidase activity GO:0008237 9.56 ACE ADAM17 MMP1 MMP13
3 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFB3
4 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB2 TGFB3
5 growth factor activity GO:0008083 9.02 AGT IL10 IL4 TGFB2 TGFB3
6 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1

Sources for Mitral Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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