MCID: MTR012
MIFTS: 56

Mitral Valve Disease malady

Cardiovascular diseases category

Summaries for Mitral Valve Disease

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MalaCards: Mitral Valve Disease, also known as mitral and aortic valve disease, unspecified, is related to congestive heart failure and hypertension. An important gene associated with Mitral Valve Disease is NPPA (natriuretic peptide A), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds norepinephrine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Mitral Valve Disease

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

mitral valve disease 8
mitral and aortic valve disease, unspecified 8
mitral and aortic valve disease nos 8
disease of mitral and aortic valves 8
diseases of mitral valve 60


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Disease Ontology8 DOID:61
ICD9CM27 424.0
NCIt39 C78446
ICD1025 I05.9, I39.0

Related Diseases for Mitral Valve Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure30.8NPPA, AGTR1, AGT, ACE
2hypertension30.8NPPA, AGTR1, AGT, NOS3, ACE
3coronary artery disease30.7NPPA, AGTR1, AGT, CXCR4, NOS3, ACE
4mitral valve prolapse30.6AGTR1
5mitral valve stenosis30.5NPPA, SELP
6dilated cardiomyopathy30.3NPPA, ACE
7migraine30.1TPH1
8arteriosclerosis30.1NOS3
9nephrotic syndrome30.1ACE, AGT, NPPA
10ischemia30.1SELP, NOS3, AGT, AKT1
11chronic kidney failure30.1NPPA, AGTR1, AGT, NOS3, ACE
12ischemic heart disease30.1NPPA, AGTR1, AGT, NOS3, ACE, SELP
13essential hypertension30.1SELP, ACE, NOS3, AGT, AGTR1, NPPA
14type 2 diabetes mellitus30.1AKT1, AGTR1, AGT, NOS3, ACE, SELP
15diabetes mellitus30.1NPPA, AKT1, AGTR1, AGT, NOS3, ACE
16rheumatic disease of mitral valve10.9
17aortic disease10.8
18pulmonary valve disease10.8
19heart valve disease10.8
20vein disease10.6
21rheumatic tricuspid valve disease10.3
22aneurysm disease10.3
23bronchial disease10.3
24endocarditis10.3
25marfan syndrome10.2
26rheumatic pulmonary valve disease10.2
27brain disease10.2
28collagen disease10.2
29infective endocarditis10.2
30respiratory failure10.2
31ventricular septal defect10.2
32williams syndrome10.2
33axenfeld-rieger syndrome10.1
34hyperlucent lung10.1
35pulmonary edema10.1
36cerebritis10.1
37systemic lupus erythematosus10.1
38intracranial aneurysm10.1
39polyarteritis nodosa10.1
40coats disease10.1
41splenic abscess10.1
42dissecting aortic aneurysm10.1
43coronary thrombosis10.1
44end stage renal failure10.1
45rheumatic mitral valve incompetence10.1
46thoracic aortic aneurysm10.1
47familial hypercholesterolemia10.1
48aortic aneurysm10.1
49kidney disease10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Mitral Valve Disease:



Diseases related to mitral valve disease

Clinical Features for Mitral Valve Disease

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Drugs & Therapeutics for Mitral Valve Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mitral Valve Disease

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Disease

Search NIH Clinical Center for Mitral Valve Disease

Search CenterWatch for Mitral Valve Disease

Genetic Tests for Mitral Valve Disease

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Anatomical Context for Mitral Valve Disease

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32MalaCards
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MalaCards organs/tissues related to Mitral Valve Disease:

32
Heart, Lung, Brain, Endothelial, Kidney, Testes, Smooth muscle, Thyroid, Skin

Animal Models for Mitral Valve Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mitral Valve Disease:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2AGTR1, AGT, ACE
2MP:00053759.2TPH1, ACE, AGT
3MP:00053888.4AKT1, CXCR4, NOS3, TPH1
4MP:00053907.9TPH1, SELP, NOS3, CXCR4, AKT1
5MP:00053697.7NPPA, AKT1, AGT, CXCR4, NOS3, TPH1
6MP:00053707.6AKT1, AGT, NOS3, ACE, SELP
7MP:00053977.3NPPA, AKT1, CXCR4, NOS3, ACE, SELP
8MP:00053876.9AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
9MP:00053866.9AKT1, AGT, NOS3, ACE, SELP, TPH1
10MP:00107686.6AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
11MP:00053786.6AKT1, AGTR1, AGT, CXCR4, NOS3, ACE
12MP:00053856.3TPH1, NPPA, AKT1, AGTR1, AGT, CXCR4
13MP:00053766.3NPPA, AKT1, AGTR1, AGT, CXCR4, NOS3

Publications for Mitral Valve Disease

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Sources:
50PubMed
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Articles related to Mitral Valve Disease:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Echocardiography in mitral valve disease. Preface. (23743080)
2013
2
The diagnostic relevance of NT-proBNP and proANP 31-67 measurements in staging of myxomatous mitral valve disease in dogs. (23614733)
2013
3
Histopathological characteristics and oxidative injury secondary to atrial fibrillation in the left atrial appendages of patients with different forms of mitral valve disease. (23158365)
2013
4
Massive left atrial calcification, tracheobronchopathia osteoplastica and mitral paravalvular leak associated with cardiac rheumatic disease and previous mitral valve replacement. (23659878)
2013
5
Developmental basis for filamin-A-associated myxomatous mitral valve disease. (22843703)
2012
6
Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease. (23113772)
2012
7
Re: Spratt J. Non-resectional repair of myxomatous mitral valve disease: the 'American Correction'. J Heart Valve Dis 2011;20:407-414. (21863654)
2011
8
Comparisons of 2- and 3-dimensional echocardiographic methods for estimation of left atrial size in dogs with and without myxomatous mitral valve disease. (22092623)
2011
9
Surgery for asymptomatic degenerative aortic and mitral valve disease. (21243010)
2011
10
Survival and durability of mitral valve repair surgery for degenerative mitral valve disease. (21793922)
2011
11
Cardiac troponin I is associated with severity of myxomatous mitral valve disease, age, and C-reactive protein in dogs. (20002554)
2010
12
Association of serum fetuin-A with valvular calcium concentration in rheumatic mitral valve disease. (21053744)
2010
13
Long-term outcomes after surgery for rheumatic mitral valve disease: valve repair versus mechanical valve replacement. (20036134)
2010
14
Effect of hydroxymethylglutaryl coenzyme-a reductase inhibitors on the long-term progression of rheumatic mitral valve disease. (20439789)
2010
15
Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease. (19912520)
2010
16
Randomized study of surgical isolation of the pulmonary veins for correction of permanent atrial fibrillation associated with mitral valve disease. (19619795)
2009
17
Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease. (18789461)
2009
18
Etiologic classification of degenerative mitral valve disease: Barlow's disease and fibroelastic deficiency. (17870001)
2007
19
Three-dimensional echocardiography in mitral valve disease. (16293531)
2005
20
Long-term results of cryoablation with a new cryoprobe to eliminate chronic atrial fibrillation associated with mitral valve disease. (15683531)
2005
21
Outcome of the modified maze procedure for atrial fibrillation combined with rheumatic mitral valve disease using cryoablation. (17670373)
2005
22
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
23
Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds. (12650472)
2003
24
Pulmonary vein isolation for chronic atrial fibrillation associated with mitral valve disease: the midterm results. (12027794)
2002
25
Preface. Atrial fibrillation in patients undergoing surgery for mitral valve disease. (12232855)
2002
26
Degenerative mitral valve disease with emphasis on mitral valve prolapse. (12369588)
2002
27
Ventricular septal defect with congenital mitral valve disease: long-term results of corrective surgery. (11999091)
2002
28
Efficacy of an additional MAZE procedure using cooled-tip radiofrequency ablation in patients with chronic atrial fibrillation and mitral valve disease. A randomized, prospective trial. (11922646)
2002
29
Combined mitral valve and coronary artery surgery: ischemic versus non-ischemic mitral valve disease. (11463543)
2001
30
Surgical strategy for severe tricuspid valve regurgitation complicated by advanced mitral valve disease: long-term outcome of tricuspid valve supra-annular implantation in eighty-eight cases. (10917943)
2000
31
Pulmonary parenchymal manifestations of mitral valve disease. (10464803)
1999
32
The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. (9699573)
1998
33
Subcellular distribution of prostaglandin-E2 and prostaglandin-F2 alpha in atrial tissue from patients with mitral valve disease. (10029898)
1998
34
BehAset's disease ('Silk Route disease') and mitral valve prolapse. (9643280)
1998
35
Left atrial reduction for chronic atrial fibrillation associated with mitral valve disease. (9692479)
1998
36
Contractile behaviour and intracellular calcium during afterloaded contraction in mitral valve disease. (9477460)
1997
37
Left atrial spontaneous echo contrast as a predictor of systemic arterial embolization in rheumatic mitral valve disease: a transesophageal echocardiographic study. (8908628)
1996
38
Left atrial spontaneous echo contrast assessed by TEE in patients with either native mitral valve disease or mitral valve replacement. (8333979)
1993
39
Ultrastructure and biosynthetic activity of polyploid atrial myocytes in patients with mitral valve disease. (1533947)
1992
40
Myocardial beta-adrenoceptor changes in heart failure: concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease. (2569001)
1989
41
Detection of left atrial thrombi by two-dimensional echocardiography and surgical correlation in 148 patients with mitral valve disease. (2741835)
1989
42
An integrated study employing histopathological, immunohistocytochemical and radioimmunoassay analyses of atrial natriuretic peptide in the right and left atria in patients with mitral valve disease. (2977197)
1988
43
Coexistent mitral valve disease with left-to-right shunt at the atrial level: clinical profile, hemodynamics, and surgical considerations in 67 consecutive patients. (3687695)
1987
44
Anomalous mitral arcade: a rare cause of mitral valve disease in an adult. (3567708)
1987
45
Smoke-like echo in the left atrial cavity in mitral valve disease: its features and significance. (4031288)
1985
46
Right ventricular function at rest and during exercise in aortic and mitral valve disease. (3964806)
1985
47
Afterload mismatch in aortic and mitral valve disease: implications for surgical therapy. (3882814)
1985
48
The effect of surgical therapy on covariate-survival relationships in patients with mitral valve disease. (7262813)
1981
49
Repeated mitral valve replacement in the growing child with congenital mitral valve disease. (7366244)
1980
50
Disturbance of respiratory muscle function in patients with mitral valve disease. (7446552)
1980

Genetic Variations for Mitral Valve Disease

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Expression for genes affiliated with Mitral Valve Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Disease

Search GEO for disease gene expression data for Mitral Valve Disease.

Pathways for genes affiliated with Mitral Valve Disease

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AGT
2
Hide members
10.0NOS3
3
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9.6AGT, AGTR1
49.1NOS3, AKT1
5
Hide members
9.1NOS3, AKT1
69.1AKT1, NOS3
78.8NOS3, AKT1, NPPA
8
Development PDGF signaling via STATs and NF-kB
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8.8AKT1, AGTR1, NOS3
98.4NOS3, CXCR4, AKT1, NPPA
10
Hide members
8.3CXCR4, AGT, AGTR1, AKT1
11
Hide members
8.1AKT1, AGTR1, AGT, ACE
12
Hide members
7.8NOS3, CXCR4, AGT, AGTR1, AKT1

Compounds for genes affiliated with Mitral Valve Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5TPH1
2estrogen4410.5TPH1
3losartan44 49 28 1112.6NPPA, AGT, SELP
4trandolapril44 1110.5ACE, NPPA, AGTR1
5cilazapril44 1110.5NPPA, AGTR1, ACE
6fosinopril44 1110.5NPPA, AGTR1, ACE
7ramipril44 1110.4ACE, NPPA, AGTR1
8aliskiren44 1110.3AGT, ACE, AGTR1
9isosorbide dinitrate44 49 1111.3NOS3, ACE, NPPA
10saralasin449.3ACE, AGT, AGTR1
11eprosartan44 28 1111.3ACE, AGTR1, AGT
12enalaprilat449.3NPPA, ACE, AGT
13kt 582344 2810.3NOS3, SELP, NPPA
14pd12331944 2810.3AGT, AGTR1, ACE
15olmesartan44 28 1111.3AGTR1, ACE, AGT
16metoprolol44 28 49 11 2413.3ACE, NPPA, NOS3
17chymostatin449.2AGTR1, AGT, ACE
18nitrendipine44 49 28 1112.2NPPA, AGTR1, ACE
19sele449.1AGT, SELP, ACE
20quinapril44 1110.1ACE, SELP, NPPA, AGTR1
21atenolol44 28 49 11 2413.1AGTR1, ACE, AGT
22benazepril44 1110.1AGT, AGTR1, NPPA, ACE
23lisinopril44 11 2411.1AGTR1, NPPA, AGT, ACE
24enalapril44 49 1111.0AGTR1, NPPA, AGT, ACE
25carvedilol44 49 28 1112.0ACE, NPPA, AGTR1, NOS3
26valsartan44 59 28 1111.9ACE, AGTR1, AGT, SELP
27telmisartan44 28 1110.9ACE, AGTR1, AGT
28sodium nitroprusside448.9TPH1, SELP, NOS3, AGTR1, NPPA
29guanylate448.7NOS3, NPPA, AGTR1, AGT
30doxazosin44 119.7AGTR1, ACE, SELP
31nitroglycerin44 119.6ACE, NPPA, AGTR1, SELP, NOS3
32perindopril44 49 1110.6AGT, AGTR1, NPPA, ACE, NOS3
33amlodipine44 49 11 2411.6NPPA, AGTR1, AGT, NOS3, ACE
34ang ii448.5NPPA, AGTR1, NOS3, ACE, AGT
35aspirin44 49 28 2411.4SELP, ACE, NOS3, AGTR1, CXCR4
36candesartan44 28 1110.4AGTR1, SELP, ACE, AGT, NOS3
37l-nmma448.3NOS3, AGT, AKT1, NPPA, AGTR1
38phenylephrine44 28 11 2411.3NPPA, NOS3, AGT, AGTR1, AKT1
39atorvastatin44 49 28 11 2412.2NOS3, SELP, AGT, AKT1
40simvastatin44 49 59 28 11 2413.2NOS3, AGT, AGTR1, AKT1, SELP
41sb 20358044 599.1AGT, AGTR1, CXCR4, NOS3, AKT1
42actinomycin d448.0AKT1, AGT, CXCR4, AGTR1, NOS3
43epinephrine44 11 2410.0NPPA, SELP, CXCR4, AGT, AKT1, AGTR1
44ly294002448.0AGT, SELP, CXCR4, NOS3, AKT1
45creatinine447.7AKT1, NPPA, SELP, ACE, AGTR1, AGT
46acetylcholine44 49 28 11 2411.7AKT1, AGT, NOS3, ACE, TPH1, AGTR1
47vegf447.4SELP, NOS3, CXCR4, AGT, AGTR1, AKT1
48nitric oxide44 11 249.3ACE, SELP, AGT, NPPA, AGTR1, NOS3
49prostacyclin447.3NOS3, NPPA, AKT1, AGTR1, AGT, ACE
50arginine447.1TPH1, NPPA, AKT1, SELP, AGTR1, AGT

GO Terms for genes affiliated with Mitral Valve Disease

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16Gene Ontology
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Cellular components related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0SELP, ACE, CXCR4

Biological processes related to Mitral Valve Disease according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:0338649.9AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:0020349.9AGTR1, AGT
3renin-angiotensin regulation of aldosterone productionGO:0020189.9AGT, AGTR1
4regulation of renal sodium excretionGO:0358139.9AGT, AGTR1
5positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
6low-density lipoprotein particle remodelingGO:0343749.8AGTR1, AGT
7regulation of blood vessel sizeGO:0508809.8NPPA, NOS3
8regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8ACE, AGTR1
9regulation of vasodilationGO:0423129.7AGTR1, ACE
10positive regulation of macrophage derived foam cell differentiationGO:0107449.7AGT, AGTR1
11regulation of renal output by angiotensinGO:0020199.7ACE, AGT
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.6AGT, AGTR1
13angiotensin maturationGO:0020039.6ACE, AGT
14nitric oxide mediated signal transductionGO:0072639.5NOS3, AGT
15positive regulation of reactive oxygen species metabolic processGO:20003799.5AGT, AGTR1
16response to fluid shear stressGO:0344059.4AKT1, NOS3
17nitric oxide biosynthetic processGO:0068099.3NOS3, AKT1
18regulation of blood pressureGO:0082179.3NPPA, NOS3, ACE
19regulation of vasoconstrictionGO:0192299.3ACE, AGT, AGTR1
20kidney developmentGO:0018229.2ACE, AGT, AGTR1
21nitric oxide metabolic processGO:0462099.2NOS3, AKT1
22blood vessel remodelingGO:0019749.2AGT, NOS3, ACE
23regulation of nitric-oxide synthase activityGO:0509999.1AKT1, NOS3
24positive regulation of cellular protein metabolic processGO:0322709.1AGT, AGTR1, AKT1
25germ cell developmentGO:0072818.9CXCR4, AKT1
26G-protein coupled receptor signaling pathwayGO:0071868.7CXCR4, AGT, AGTR1, AKT1

Molecular functions related to Mitral Valve Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.5ACE, AGTR1
2acetyltransferase activator activityGO:0106989.3AGT, AGTR1

Products for genes affiliated with Mitral Valve Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitral Valve Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet