MCID: MTR002
MIFTS: 46

Mitral Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Insufficiency

MalaCards integrated aliases for Mitral Valve Insufficiency:

Name: Mitral Valve Insufficiency 12 41 14 69
Mitral Regurgitation 12 28 51
Congenital Insufficiency of Mitral Valve 12 69
Congenital Mitral Insufficiency 12
Congenital Mitral Regurgitation 12
Mitral Valve Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11502
ICD10 32 Q23.3
ICD9CM 34 396.3 746.6
MeSH 41 D008944

Summaries for Mitral Valve Insufficiency

MalaCards based summary : Mitral Valve Insufficiency, also known as mitral regurgitation, is related to mitral valve disease and orthostatic intolerance. An important gene associated with Mitral Valve Insufficiency is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Cardiomyocyte Differentiation through BMP Receptors. The drugs Ranolazine and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related phenotype is cardiovascular system.

Related Diseases for Mitral Valve Insufficiency

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 mitral valve disease 32.7 ACE FBN1 NPPA
2 orthostatic intolerance 32.3 DCHS1 FBN1 PDLIM1
3 congestive heart failure 30.2 ACE NPPA NPPB
4 coronary artery anomaly 30.1 ACE NPPA NPPB
5 mitral valve stenosis 29.1 CEP57 CRELD1 HCK NPPA NPPB SAMHD1
6 macrothrombocytopenia with mitral valve insufficiency 12.2
7 mitral valve prolapse 1 11.7
8 cardiospondylocarpofacial syndrome 11.5
9 mitral valve prolapse, familial, x-linked 11.1
10 ehlers-danlos syndrome, cardiac valvular type 11.1
11 mitral valve prolapse 2 11.1
12 central sleep apnea 10.5 NPPA NPPB
13 hypoaldosteronism 10.5 ACE NPPA
14 renal artery disease 10.4 ACE NPPA
15 ebstein anomaly 10.4 CRELD1 NPPB
16 vasculogenic impotence 10.4 ACE NPPA
17 inferior myocardial infarction 10.4 NPPB SULT1E1
18 syncope 10.4 NPPA NPPB
19 aortic coarctation 10.4 ACE FBN1
20 diastolic heart failure 10.4 ACE NPPB
21 tricuspid valve disease 10.4 CRELD1 FBN1 NPPB
22 tricuspid valve insufficiency 10.4 CRELD1 FBN1 NPPB
23 anterolateral myocardial infarction 10.3 ACE NPPA NPPB
24 aortic valve insufficiency 10.3 ACE FBN1 NPPB
25 syndrome of inappropriate antidiuretic hormone 10.3 ACE NPPA NPPB
26 optic nerve sheath meningioma 10.3 ACE SAMHD1
27 malignant hypertension 10.3 ACE NPPA
28 idiopathic edema 10.3 ACE NPPA NPPB
29 ischemic heart disease 10.3 ACE NPPB
30 patent ductus arteriosus 1 10.3 CRELD1 NPPB
31 acute myocardial infarction 10.3 ACE NPPA NPPB
32 malignant essential hypertension 10.3 ACE SAMHD1
33 systolic heart failure 10.3 ACE NPPB
34 supravalvular aortic stenosis 10.2 FBN1 PDLIM1
35 tetralogy of fallot 10.2 CRELD1 FBN1 NPPA NPPB
36 posterior myocardial infarction 10.2 IL4I1 SULT1E1
37 cleft mitral valve 10.1
38 congenital unguarded mitral orifice 10.1
39 mitral valve agenesis 10.1
40 tricuspid valve stenosis 10.1 CRELD1 FBN1 IL4I1
41 hepatorenal syndrome 10.1 ACE NPPA
42 anteroseptal myocardial infarction 10.1 EFS SULT1E1
43 atrial fibrillation 10.0 ACE NPPA NPPB
44 renal hypertension 10.0 ACE NPPB
45 heart disease 9.9 ACE CRELD1 FBN1 NPPA NPPB
46 aging 9.8
47 tendinitis 9.8
48 hemolytic anemia 9.8
49 arteries, anomalies of 9.8
50 ventricular fibrillation, paroxysmal familial, 1 9.8

Graphical network of the top 20 diseases related to Mitral Valve Insufficiency:



Diseases related to Mitral Valve Insufficiency

Symptoms & Phenotypes for Mitral Valve Insufficiency

MGI Mouse Phenotypes related to Mitral Valve Insufficiency:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.23 ACE CRELD1 DCHS1 FBN1 HCK NPPA

Drugs & Therapeutics for Mitral Valve Insufficiency

Drugs for Mitral Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 738)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4 95635-55-5, 142387-99-3 56959
2
Amlodipine Approved Phase 4 88150-42-9 2162
3
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
4
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
5
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
6
Liraglutide Approved Phase 4,Phase 2 204656-20-2 44147092
7
Ranibizumab Approved Phase 4 347396-82-1 459903
8
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
9
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
10
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
11
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
12
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
13
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
14
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1 120202-66-6, 113665-84-2 60606
15
Ticlopidine Approved Phase 4,Phase 3,Phase 1 55142-85-3 5472
16
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 46507594 772
17
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2 99-66-1 3121
18
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
19
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
20
Cocaine Approved, Illicit Phase 4,Phase 1 50-36-2 446220 5760
21
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
22
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
23
Insulin Detemir Approved Phase 4 169148-63-4 5311023
24
Infliximab Approved Phase 4,Phase 2 170277-31-3
25
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 4091 14219
26
Warfarin Approved Phase 4,Phase 1 81-81-2 54678486 6691
27
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 51384-51-1, 37350-58-6 4171
28
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
29
Acetylcholine Approved Phase 4 51-84-3 187
30
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19982-08-2 4054
31
Cosyntropin Approved Phase 4 16960-16-0 16129617
32
Etomidate Approved Phase 4 33125-97-2 667484 36339
33
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 657311 5754
34
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
35
Citalopram Approved Phase 4 59729-33-8 2771
36
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
37
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
38
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
39
Donepezil Approved Phase 4,Phase 3 120014-06-4 3152
40
Galantamine Approved Phase 4 357-70-0 9651
41
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
42
Argatroban Approved, Investigational Phase 4 74863-84-6 152951
43
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
44
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
45
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
46
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
47
Thrombin Approved, Investigational Phase 4
48
Gliclazide Approved Phase 4 21187-98-4 3475
49
Insulin Glargine Approved Phase 4,Phase 2 160337-95-1
50
Midazolam Approved, Illicit Phase 4 59467-70-8 4192

Interventional clinical trials:

(show top 50) (show all 1317)

# Name Status NCT ID Phase Drugs
1 Surgical Treatment of Ischemic Mitral Regurgitation Unknown status NCT01368575 Phase 4
2 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
3 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
4 ACTIV- Exercise Intervention in Healthy Young Men Unknown status NCT00401791 Phase 4
5 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4 Lovaza group
6 Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis Unknown status NCT01956409 Phase 4 18F-FCH;Magnevist
7 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
8 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
9 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
10 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
11 Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism Unknown status NCT02721888 Phase 4 Liraglutide;MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
12 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
13 Master Study for the Investigation of Safety and Efficacy of the SIELLO Pacemaker Leads Unknown status NCT00943046 Phase 4
14 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
15 Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children Unknown status NCT01878994 Phase 4
16 Effectiveness and Safety of Yiqitongluo Granule for Stroke Unknown status NCT02604654 Phase 4 Yiqitongluo granule
17 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
18 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
19 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
20 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation Completed NCT02687932 Phase 4 LCZ696;Valsartan
21 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4 Candesartan;atacand;Placebo
22 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
23 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
24 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
25 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
26 Functional Effects of Botox on the Brain Using MRS and fMRI Completed NCT03373162 Phase 4 onabotulinumtoxinA
27 Evaluation Of HUK in Acute Stroke Patients: MRS and CTP Completed NCT03431909 Phase 4 Human urinary kallidinogenase (HUK);aspirin® , clopidogrel® , atorvastatin®
28 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed NCT00933608 Phase 4 memantine;Placebo
29 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
30 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
31 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed NCT00826111 Phase 4 Eszopiclone;Placebo
32 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
33 Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Completed NCT00478478 Phase 4
34 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
35 Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder Completed NCT00181883 Phase 4 quetiapine
36 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
37 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
38 Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate Completed NCT00593112 Phase 4 OROS methylphenidate
39 Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease Completed NCT00551161 Phase 4 memantine
40 Argatroban for Preventing Occlusion and Restenosis After Extracranial Vertebral Artery Stenting Completed NCT01980316 Phase 4 Argatroban;non-argatroban treated group
41 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Completed NCT01372748 Phase 4
42 Biomarker Assessment of Glutamatergic Target Engagement Completed NCT02134951 Phase 4 Ketamine;Normal saline
43 Quetiapine Related Neurochemical Changes as Measured by Magnetic Resonance Spectroscopy in Schizophrenia Completed NCT00797927 Phase 4 quetiapine
44 Comparison of the Administration of Levosimendan and Placebo in the Preparation of Critical Patients for Heart Surgery Completed NCT01595737 Phase 4 Levosimendan;Placebo
45 Depakote ER in Bipolar Depression Completed NCT00186186 Phase 4 Depakote ER
46 Attenuation of Corticosteroid Induced Hippocampal Changes Completed NCT01656187 Phase 4 Memantine;Placebo
47 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed NCT00678574 Phase 4 fluoxetine
48 Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke Completed NCT00153946 Phase 4 Edaravone
49 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
50 Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes Completed NCT00736515 Phase 4 Gliclazide MR and Insulin Glargine Injection;Biosynthetic Human Insulin Injection

Search NIH Clinical Center for Mitral Valve Insufficiency

Cochrane evidence based reviews: mitral valve insufficiency

Genetic Tests for Mitral Valve Insufficiency

Genetic tests related to Mitral Valve Insufficiency:

# Genetic test Affiliating Genes
1 Mitral Regurgitation 28

Anatomical Context for Mitral Valve Insufficiency

MalaCards organs/tissues related to Mitral Valve Insufficiency:

38
Brain, Heart, Liver, Prostate, Testes, Skeletal Muscle, Bone

Publications for Mitral Valve Insufficiency

Articles related to Mitral Valve Insufficiency:

(show all 50)
# Title Authors Year
1
Repair Techniques for Mitral Valve Insufficiency in Children. ( 29425524 )
2018
2
DOK7 congenital myasthenia may be associated with severe mitral valve insufficiency. ( 28716243 )
2017
3
Inheritance Impacts Mitral Valve Insufficiency. ( 28993408 )
2017
4
Three Cases of Aneurysmatic Coronary Fistulas Associated With Mitral Valve Insufficiency. ( 28528052 )
2017
5
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency. ( 26733738 )
2016
6
Surgical Repair of Congenital Left Atrial Aneurysm and Mitral Valve Insufficiency in a Four-Year-Old Child. ( 27956709 )
2016
7
Cardiac remodelling and function with primary mitral valve insufficiency studied by magnetic resonance imaging. ( 26758406 )
2016
8
Occurrence of mitral valve insufficiency in clinically healthy Beagle dogs. ( 26599093 )
2015
9
Review of mitral valve insufficiency: repair or replacement. ( 24672698 )
2014
10
Clinical assessment of systolic myocardial deformations in dogs with chronic mitral valve insufficiency using two-dimensional speckle-tracking echocardiography. ( 23429036 )
2013
11
Comparison of the novel Medtentia double helix mitral annuloplasty system with the Carpentier-Edwards Physio annuloplasty ring: morphological and functional long-term outcome in a mitral valve insufficiency sheep model. ( 23566678 )
2013
12
Surgical reconstruction techniques for mitral valve insufficiency from lesions with restricted leaflet motion in infants and children. ( 22169677 )
2012
13
Evaluation of homocysteine levels in dogs with chronic mitral valve insufficiency. ( 22811561 )
2012
14
High-grade mitral valve insufficiency after fracture of the Mitrofix prosthesis. ( 21982121 )
2011
15
Accessory left atrial chordae: an unusual cause of mitral valve insufficiency. ( 19660254 )
2010
16
Mitral valve growth after posterior annular stabilization with untreated autologous pericardial strip in children with mitral valve insufficiency. ( 20971267 )
2010
17
Diagnosis of acute mitral valve insufficiency using emergency bedside echocardiography. ( 19549012 )
2009
18
Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency. ( 19652480 )
2009
19
Severe mitral valve insufficiency after transcatheter atrial septal defect closure with the amplatzer septal occluder: a device-related complication. ( 20078713 )
2009
20
Ventricular fibrillation in acute mitral valve insufficiency caused by chordae tendineae rupture: report of a surgically corrected case. ( 19283885 )
2009
21
De novo 18q deletion with mitral valve insufficiency. ( 18990980 )
2008
22
Mitral valve insufficiency: suspension of the posterior leaflet to the mitral annuloplasty ring. ( 18222224 )
2008
23
Decreased systolic function and inadequate hypertrophy in large and small breed dogs with chronic mitral valve insufficiency. ( 17338151 )
2007
24
Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency. ( 17916031 )
2007
25
Degenerative mitral valve insufficiency long term after heart transplantation: clinical and surgical considerations. ( 17484457 )
2007
26
Mitral valve insufficiency and left ventricular remodeling in identical twins. ( 16733180 )
2006
27
Experimental stenting of the posterior mitral leaflet to correct prolapse in mitral valve insufficiency. ( 16112933 )
2005
28
Echocardiographic estimation of mean left atrial pressure in a canine model of acute mitral valve insufficiency. ( 15515583 )
2004
29
Economic impact of mitral valve plasty versus replacement for mitral valve insufficiency. ( 12813377 )
2003
30
Effects of the ACE inhibitor quinapril on echocardiographic variables in horses with mitral valve insufficiency. ( 15109241 )
2003
31
Very long-term results (more than 20 years) of valve repair with carpentier's techniques in nonrheumatic mitral valve insufficiency. ( 11568021 )
2001
32
Long-term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. ( 11568022 )
2001
33
Acute traumatic mitral valve insufficiency. ( 10421207 )
1999
34
Correlation between clinical and histologic patterns of degenerative mitral valve insufficiency: a histomorphometric study of 130 excised segments. ( 10724505 )
1999
35
Pulmonary sequestration presenting as mitral valve insufficiency. ( 9856886 )
1998
36
Reconstructive surgery in congenital mitral valve insufficiency (Carpentier's techniques): long-term results. ( 9451050 )
1998
37
Giant platelets with abnormal surface glycoproteins: a new familial disorder associated with mitral valve insufficiency. ( 9482416 )
1998
38
Effects of mild mitral valve insufficiency, sodium intake, and place of blood sampling on the renin-angiotensin system in dogs. ( 8659339 )
1996
39
Results of mitral valve reconstruction in mitral valve insufficiency. ( 7775539 )
1994
40
Prevalence of mitral valve insufficiency in cavalier King Charles spaniels. ( 1595150 )
1992
41
In vitro balloon dilatation of mitral valve stenosis: the importance of subvalvar involvement as a cause of mitral valve insufficiency. ( 2039673 )
1991
42
Increased mitral valve insufficiency during precordial whoop. ( 3383646 )
1988
43
Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. ( 2969307 )
1988
44
Mitral valve insufficiency with congestive heart failure in a pukeko. ( 7451347 )
1980
45
Left ventricular angiocardiography in congenital mitral valve insufficiency of the dog. ( 1133066 )
1975
46
EKG of the month. Mitral valve insufficiency. ( 4756262 )
1973
47
Iatrogenic myocardial infarction and mitral valve insufficiency in a llama (Lama glama). ( 5014471 )
1972
48
Treatment of acute mitral valve insufficiency. ( 5269781 )
1970
49
An unusual form of mitral valve insufficiency simulating aortic stenosis. ( 5506636 )
1970
50
The effect of acute mitral valve insufficiency on left-heart haemodynamics. ( 5427889 )
1970

Variations for Mitral Valve Insufficiency

Expression for Mitral Valve Insufficiency

Search GEO for disease gene expression data for Mitral Valve Insufficiency.

Pathways for Mitral Valve Insufficiency

Pathways related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 NPPA NPPB PIK3R2
2 10.3 NPPA NPPB
3 9.88 HCK PIK3R2

GO Terms for Mitral Valve Insufficiency

Biological processes related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.43 ACE DCHS1 FBN1
2 cGMP biosynthetic process GO:0006182 9.37 NPPA NPPB
3 regulation of blood vessel size GO:0050880 9.32 NPPA NPPB
4 regulation of blood vessel diameter GO:0097746 9.16 ACE NPPB
5 receptor guanylyl cyclase signaling pathway GO:0007168 8.96 NPPA NPPB
6 regulation of blood pressure GO:0008217 8.8 ACE NPPA NPPB

Molecular functions related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 FBN1 NPPA NPPB
2 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Mitral Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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