MCID: MTR002
MIFTS: 45

Mitral Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Mitral Valve Insufficiency

MalaCards integrated aliases for Mitral Valve Insufficiency:

Name: Mitral Valve Insufficiency 12 42 14 69
Mitral Regurgitation 12 29 52
Congenital Insufficiency of Mitral Valve 12 69
Congenital Mitral Insufficiency 12
Congenital Mitral Regurgitation 12
Mitral Valve Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11502
ICD10 33 Q23.3
ICD9CM 35 396.3 746.6
MeSH 42 D008944

Summaries for Mitral Valve Insufficiency

MalaCards based summary : Mitral Valve Insufficiency, also known as mitral regurgitation, is related to artery disease and macrothrombocytopenia with mitral valve insufficiency. An important gene associated with Mitral Valve Insufficiency is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Alanine, aspartate and glutamate metabolism. The drugs Ranolazine and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver.

Related Diseases for Mitral Valve Insufficiency

Diseases in the Mitral Valve Disease family:

Mitral Valve Insufficiency

Diseases related to Mitral Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 artery disease 30.5 CRELD1 FBN1 NPPB
2 macrothrombocytopenia with mitral valve insufficiency 12.1
3 cardiospondylocarpofacial syndrome 11.3
4 mitral valve disease 11.2
5 mitral valve prolapse, familial, x-linked 11.0
6 mitral valve prolapse 2 11.0
7 mitral valve prolapse, myxomatous 1 11.0
8 ehlers-danlos syndrome, cardiac valvular form 11.0
9 pyriform sinus cancer 10.7 NPPA NPPB
10 atrial septal defect 7, with or without av conduction defects 10.7 ACE NPPA
11 hypodontia of incisors and premolars 10.7 ACE NPPA
12 macroglossia 10.7 CRELD1 NPPB
13 clitoris cancer 10.7 ACE NPPA
14 lateral myocardial infarction 10.7 NPPB SULT1E1
15 epithelial predominant pulmonary blastoma 10.7 ACE NPPA
16 vascular erectile tumor 10.7 NPPA NPPB
17 aortopulmonary window 10.6 ACE FBN1
18 trichinosis 10.6 ACE NPPB
19 testicular germ cell tumor non-seminomatous 10.6 CRELD1 FBN1 NPPB
20 cervical adenosquamous carcinoma 10.6 ACE SAMHD1
21 islet cell tumor 10.6 ACE NPPB
22 chylocele of tunica vaginalis 10.6 ACE NPPA
23 pleomorphic liposarcoma 10.5 ACE FBN1 NPPB
24 synovial chondromatosis 10.5 ACE NPPA NPPB
25 idiopathic juxtafoveal retinal telangiectasia 10.5 ACE NPPA NPPB
26 placental abruption 10.5 ACE NPPB
27 thoracic spinal canal and spinal cord meningioma 10.5 ACE FBN1 NPPA
28 cutis laxa, autosomal dominant 10.5 FBN1 PDLIM1
29 voyeurism 10.5 ACE SAMHD1
30 adult respiratory distress syndrome 10.5 ACE NPPA NPPB
31 craniosynostosis 10.5 ACE NPPA NPPB
32 myopia 10.5 ACE NPPA
33 broad ligament malignant neoplasm 10.4 ACE NPPB
34 lymphadenitis 10.3 ACE NPPA
35 pyogenic arthritis, pyoderma gangrenosum and acne 10.3 ACE NPPA
36 localized chondrosarcoma 10.3 EFS SULT1E1
37 hypothyroidism, congenital nongoitrous, 5 10.3 CRELD1 FBN1 NPPA NPPB
38 acrofrontofacionasal dysostosis 10.3 ACE NPPA NPPB
39 opiate dependence 10.1 ACE SAMHD1
40 inferior myocardial infarction 10.0 IL4I1 SULT1E1
41 xanthogranulomatous pyelonephritis 10.0 ACE CRELD1 FBN1 NPPA NPPB
42 congenital unguarded mitral orifice 10.0
43 mitral valve agenesis 10.0
44 cleft mitral valve 10.0
45 trophoblastic neoplasm 9.9 CRELD1 FBN1 IL4I1
46 abducens nerve disease 9.9 HCK SAMHD1
47 atrioventricular septal defect 9.8
48 cor triatriatum 9.8
49 tendinitis 9.7
50 hemolytic anemia 9.7

Graphical network of the top 20 diseases related to Mitral Valve Insufficiency:



Diseases related to Mitral Valve Insufficiency

Symptoms & Phenotypes for Mitral Valve Insufficiency

Drugs & Therapeutics for Mitral Valve Insufficiency

Drugs for Mitral Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 710)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
2
Amlodipine Approved Phase 4 88150-42-9 2162
3
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
4
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
5
Ranibizumab Approved Phase 4 347396-82-1 459903
6
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
7
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
8
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
9
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
10
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3 37350-58-6, 51384-51-1 4171
11
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
12
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
13
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
14
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2 99-66-1 3121
15
Antipyrine Approved Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
16
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
17
Cocaine Approved, Illicit Phase 4,Phase 1 50-36-2 5760 446220
18
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
19
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
20
Insulin Detemir Approved Phase 4 169148-63-4 5311023
21
Infliximab Approved Phase 4,Phase 2 170277-31-3
22
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
23
Warfarin Approved Phase 4,Phase 1 81-81-2 6691 54678486
24
Candesartan Approved Phase 4 139481-59-7 2541
25
Phosphocreatine Approved Phase 4 67-07-2 587
26
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
27
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19982-08-2 4054
28
Cosyntropin Approved Phase 4 16960-16-0 16129617
29
Etomidate Approved Phase 4 33125-97-2 36339 667484
30
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
31
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
32
Citalopram Approved Phase 4 59729-33-8 2771
33
Eszopiclone Approved Phase 4 138729-47-2 969472
34
Cilostazol Approved Phase 4 73963-72-1 2754
35
Ticlopidine Approved Phase 4,Phase 3,Phase 1 55142-85-3 5472
36
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
37
Donepezil Approved Phase 4,Phase 3 120014-06-4 3152
38
Galantamine Approved Phase 4 357-70-0 9651
39
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
40
Argatroban Approved, Investigational Phase 4 74863-84-6 152951
41
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
42
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
43
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
44
Thrombin Approved Phase 4
45
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
46
Gliclazide Approved Phase 4 21187-98-4 3475
47
Insulin Glargine Approved Phase 4,Phase 2 160337-95-1
48
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
49
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
50
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124

Interventional clinical trials:

(show top 50) (show all 1254)

id Name Status NCT ID Phase Drugs
1 Surgical Treatment of Ischemic Mitral Regurgitation Unknown status NCT01368575 Phase 4
2 Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery Unknown status NCT01431222 Phase 4
3 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
4 Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Unknown status NCT01046604 Phase 4 Lovaza group
5 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
6 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
7 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
8 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
9 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
10 Master Study for the Investigation of Safety and Efficacy of the SIELLO Pacemaker Leads Unknown status NCT00943046 Phase 4
11 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
12 Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children Unknown status NCT01878994 Phase 4
13 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
14 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
15 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
16 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4 Candesartan;atacand;Placebo
17 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. Completed NCT00166400 Phase 4 metoprolol succinate
18 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
19 CG Future® Annuloplasty Ring/Band Clinical Trial Completed NCT01074671 Phase 4
20 The Use of Paravertebral Block for Cardiac Surgery Completed NCT02180893 Phase 4
21 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed NCT00933608 Phase 4 memantine;Placebo
22 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
23 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
24 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed NCT00826111 Phase 4 Eszopiclone;Placebo
25 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
26 Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Completed NCT00478478 Phase 4
27 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
28 Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder Completed NCT00181883 Phase 4 quetiapine
29 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
30 Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate Completed NCT00593112 Phase 4 OROS methylphenidate
31 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
32 Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease Completed NCT00551161 Phase 4 memantine
33 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Completed NCT01372748 Phase 4
34 Argatroban for Preventing Occlusion and Restenosis After Extracranial Vertebral Artery Stenting Completed NCT01980316 Phase 4 Argatroban;non-argatroban treated group
35 Quetiapine Related Neurochemical Changes as Measured by Magnetic Resonance Spectroscopy in Schizophrenia Completed NCT00797927 Phase 4 quetiapine
36 Depakote ER in Bipolar Depression Completed NCT00186186 Phase 4 Depakote ER
37 Biomarker Assessment of Glutamatergic Target Engagement Completed NCT02134951 Phase 4 Ketamine;Normal saline
38 Comparison of the Administration of Levosimendan and Placebo in the Preparation of Critical Patients for Heart Surgery Completed NCT01595737 Phase 4 Levosimendan;Placebo
39 Attenuation of Corticosteroid Induced Hippocampal Changes Completed NCT01656187 Phase 4 Memantine;Placebo
40 Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke Completed NCT00153946 Phase 4 Edaravone
41 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed NCT00678574 Phase 4 fluoxetine
42 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
43 Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes Completed NCT00736515 Phase 4 Gliclazide MR and Insulin Glargine Injection;Biosynthetic Human Insulin Injection
44 Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder Completed NCT00626340 Phase 4 MDD diagnosis and Estrogen treatment;MDD diagnosis and Fluoxetine treatment;MDD diagnosis with both Estrogen and Fluoxetine treatment;No depression and estrogen treatment
45 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
46 Premedication for ERCP With Midazolam or Tramadol Completed NCT02436980 Phase 4 Tramadol;Midazolam
47 Valproic Acid Sodium Salt in Bipolar Disorder Completed NCT00431522 Phase 4 Valproic acid, sodium salt
48 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
49 Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction Completed NCT02626494 Phase 4 N-Acetylcystein;Placebo
50 Minocycline for Bipolar Depression Completed NCT01514422 Phase 4 Minocycline

Search NIH Clinical Center for Mitral Valve Insufficiency

Cochrane evidence based reviews: mitral valve insufficiency

Genetic Tests for Mitral Valve Insufficiency

Genetic tests related to Mitral Valve Insufficiency:

id Genetic test Affiliating Genes
1 Mitral Regurgitation 29

Anatomical Context for Mitral Valve Insufficiency

MalaCards organs/tissues related to Mitral Valve Insufficiency:

39
Brain, Heart, Liver, Breast, Prostate, Testes, Skeletal Muscle

Publications for Mitral Valve Insufficiency

Articles related to Mitral Valve Insufficiency:

(show all 48)
id Title Authors Year
1
DOK7 congenital myasthenia may be associated with severe mitral valve insufficiency. ( 28716243 )
2017
2
Three Cases of Aneurysmatic Coronary Fistulas Associated With Mitral Valve Insufficiency. ( 28528052 )
2017
3
Cardiac remodelling and function with primary mitral valve insufficiency studied by magnetic resonance imaging. ( 26758406 )
2016
4
Surgical Repair of Congenital Left Atrial Aneurysm and Mitral Valve Insufficiency in a Four-Year-Old Child. ( 27956709 )
2016
5
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency. ( 26733738 )
2016
6
Occurrence of mitral valve insufficiency in clinically healthy Beagle dogs. ( 26599093 )
2015
7
Review of mitral valve insufficiency: repair or replacement. ( 24672698 )
2014
8
Comparison of the novel Medtentia double helix mitral annuloplasty system with the Carpentier-Edwards Physio annuloplasty ring: morphological and functional long-term outcome in a mitral valve insufficiency sheep model. ( 23566678 )
2013
9
Clinical assessment of systolic myocardial deformations in dogs with chronic mitral valve insufficiency using two-dimensional speckle-tracking echocardiography. ( 23429036 )
2013
10
Surgical reconstruction techniques for mitral valve insufficiency from lesions with restricted leaflet motion in infants and children. ( 22169677 )
2012
11
Evaluation of homocysteine levels in dogs with chronic mitral valve insufficiency. ( 22811561 )
2012
12
High-grade mitral valve insufficiency after fracture of the Mitrofix prosthesis. ( 21982121 )
2011
13
Accessory left atrial chordae: an unusual cause of mitral valve insufficiency. ( 19660254 )
2010
14
Mitral valve growth after posterior annular stabilization with untreated autologous pericardial strip in children with mitral valve insufficiency. ( 20971267 )
2010
15
Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency. ( 19652480 )
2009
16
Diagnosis of acute mitral valve insufficiency using emergency bedside echocardiography. ( 19549012 )
2009
17
Ventricular fibrillation in acute mitral valve insufficiency caused by chordae tendineae rupture: report of a surgically corrected case. ( 19283885 )
2009
18
Severe mitral valve insufficiency after transcatheter atrial septal defect closure with the amplatzer septal occluder: a device-related complication. ( 20078713 )
2009
19
De novo 18q deletion with mitral valve insufficiency. ( 18990980 )
2008
20
Mitral valve insufficiency: suspension of the posterior leaflet to the mitral annuloplasty ring. ( 18222224 )
2008
21
Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency. ( 17916031 )
2007
22
Degenerative mitral valve insufficiency long term after heart transplantation: clinical and surgical considerations. ( 17484457 )
2007
23
Decreased systolic function and inadequate hypertrophy in large and small breed dogs with chronic mitral valve insufficiency. ( 17338151 )
2007
24
Mitral valve insufficiency and left ventricular remodeling in identical twins. ( 16733180 )
2006
25
Experimental stenting of the posterior mitral leaflet to correct prolapse in mitral valve insufficiency. ( 16112933 )
2005
26
Echocardiographic estimation of mean left atrial pressure in a canine model of acute mitral valve insufficiency. ( 15515583 )
2004
27
Economic impact of mitral valve plasty versus replacement for mitral valve insufficiency. ( 12813377 )
2003
28
Effects of the ACE inhibitor quinapril on echocardiographic variables in horses with mitral valve insufficiency. ( 15109241 )
2003
29
Long-term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. ( 11568022 )
2001
30
Very long-term results (more than 20 years) of valve repair with carpentier's techniques in nonrheumatic mitral valve insufficiency. ( 11568021 )
2001
31
Acute traumatic mitral valve insufficiency. ( 10421207 )
1999
32
Correlation between clinical and histologic patterns of degenerative mitral valve insufficiency: a histomorphometric study of 130 excised segments. ( 10724505 )
1999
33
Reconstructive surgery in congenital mitral valve insufficiency (Carpentier's techniques): long-term results. ( 9451050 )
1998
34
Pulmonary sequestration presenting as mitral valve insufficiency. ( 9856886 )
1998
35
Giant platelets with abnormal surface glycoproteins: a new familial disorder associated with mitral valve insufficiency. ( 9482416 )
1998
36
Effects of mild mitral valve insufficiency, sodium intake, and place of blood sampling on the renin-angiotensin system in dogs. ( 8659339 )
1996
37
Results of mitral valve reconstruction in mitral valve insufficiency. ( 7775539 )
1994
38
Prevalence of mitral valve insufficiency in cavalier King Charles spaniels. ( 1595150 )
1992
39
In vitro balloon dilatation of mitral valve stenosis: the importance of subvalvar involvement as a cause of mitral valve insufficiency. ( 2039673 )
1991
40
Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. ( 2969307 )
1988
41
Increased mitral valve insufficiency during precordial whoop. ( 3383646 )
1988
42
Mitral valve insufficiency with congestive heart failure in a pukeko. ( 7451347 )
1980
43
Left ventricular angiocardiography in congenital mitral valve insufficiency of the dog. ( 1133066 )
1975
44
EKG of the month. Mitral valve insufficiency. ( 4756262 )
1973
45
Iatrogenic myocardial infarction and mitral valve insufficiency in a llama (Lama glama). ( 5014471 )
1972
46
The effect of acute mitral valve insufficiency on left-heart haemodynamics. ( 5427889 )
1970
47
Treatment of acute mitral valve insufficiency. ( 5269781 )
1970
48
An unusual form of mitral valve insufficiency simulating aortic stenosis. ( 5506636 )
1970

Variations for Mitral Valve Insufficiency

Expression for Mitral Valve Insufficiency

Search GEO for disease gene expression data for Mitral Valve Insufficiency.

Pathways for Mitral Valve Insufficiency

Pathways related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 NPPA NPPB PIK3R2
2 10.8 GLS IL4I1
3 10.3 NPPA NPPB
4 9.88 HCK PIK3R2

GO Terms for Mitral Valve Insufficiency

Biological processes related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.43 NPPA PDLIM1
2 cGMP biosynthetic process GO:0006182 9.4 NPPA NPPB
3 regulation of blood vessel size GO:0050880 9.37 NPPA NPPB
4 regulation of blood vessel diameter GO:0097746 9.26 ACE NPPB
5 receptor guanylyl cyclase signaling pathway GO:0007168 9.16 NPPA NPPB
6 cell growth involved in cardiac muscle cell development GO:0061049 9.02 NPPA
7 regulation of blood pressure GO:0008217 8.8 ACE NPPA NPPB
8 negative regulation of systemic arterial blood pressure GO:0003085 8.65 NPPA

Molecular functions related to Mitral Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphotyrosine binding GO:0001784 9.16 HCK PIK3R2
2 hormone activity GO:0005179 9.13 FBN1 NPPA NPPB
3 peptide hormone receptor binding GO:0051428 8.32 NPPA

Sources for Mitral Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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