MCID: MTR005
MIFTS: 59

Mitral Valve Prolapse malady

Genetic diseases, Cardiovascular diseases, Fetal diseases, Rare diseases categories
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Summaries for Mitral Valve Prolapse

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34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards: Mitral Valve Prolapse, also known as mitral valve prolapse syndrome, is related to mood disorder and hypercholesterolemia. An important gene associated with Mitral Valve Prolapse is FBN1 (fibrillin 1), and among its related pathways are Arf6 signaling events and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cv 11974 and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:65 Mitral valve prolapse (aka primary form of myxomatous degeneration of the mitral valve aka floppy mitral... more...

Description from OMIM:47 157700

Aliases & Classifications for Mitral Valve Prolapse

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 47OMIM
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Classifications:



Aliases & Descriptions:

mitral valve prolapse 8 10 45 34
mitral valve prolapse syndrome 62
floppy mitral valve 8
barlows syndrome 8


External Ids:

Disease Ontology8 DOID:988
MeSH35 D008945
NCIt40 C50655
OMIM47 157700

Related Diseases for Mitral Valve Prolapse

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17GeneCards, 18GeneDecks
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Diseases in the Mitral Valve Prolapse family:

Familial Mitral Valve Prolapse

Diseases related to Mitral Valve Prolapse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1mood disorder30.4SLC6A2, DBH
2hypercholesterolemia30.4FBN1, AGT, AGTR1
3coronary artery disease30.3AGTR1, AGT, FBN1
4hypertension30.3AGTR1, AGT, DBH
5endocarditis10.8
6aneurysm10.8
7familial mitral valve prolapse10.7
8panic disorder10.7
9marfan syndrome10.7
10atrial septal aneurysm10.7
11neurocirculatory asthenia10.6
12cerebritis10.6
13infective endocarditis10.5
14ischemia10.5
15thromboembolism10.5
16hypertrophic cardiomyopathy10.5
17hypermobility syndrome10.5
18anxiety disorder10.5
19migraine10.5
20myocarditis10.5
21thyroiditis10.5
22hypogonadism mitral valve prolapse mental retardation10.5
23mitral valve prolapse, familial, x-linked10.5
24hypogonadism - mitral valve prolapse - intellectual disability10.5
25rheumatic fever10.4
26rheumatic heart disease10.4
27endomyocardial fibrosis10.4
28type vi ehlers-danlos syndrome10.4
29type i ehlers-danlos syndrome10.4
30systemic lupus erythematosus10.4
31stickler syndrome10.4
32brain disease10.4
33esophagitis10.4
34keratoconus10.4
35lupus erythematosus10.4
36pneumothorax10.4
37mass syndrome10.4
38mitral valve prolapse, familial, autosomal dominant10.4
39stickler syndrome type 110.4
40spontaneous pneumothorax10.4
41left ventricular outflow tract obstruction10.4
42mental retardation10.4
43primary spontaneous pneumothorax10.4
44dysautonomia10.4
45myotonia10.4
46syncope10.4
47mitral valve prolapse, myxomatous 210.4
48mitral valve prolapse, myxomatous 310.4
49mitral valve prolapse, myxomatous 110.4
50subvalvular aortic stenosis10.3

Graphical network of the top 20 diseases related to Mitral Valve Prolapse:



Diseases related to mitral valve prolapse

Symptoms for Mitral Valve Prolapse

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47OMIM
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Clinical features from OMIM:

157700

Drugs & Therapeutics for Mitral Valve Prolapse

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mitral Valve Prolapse

Search NIH Clinical Center for Mitral Valve Prolapse

Genetic Tests for Mitral Valve Prolapse

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Anatomical Context for Mitral Valve Prolapse

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33MalaCards
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MalaCards organs/tissues related to Mitral Valve Prolapse:

33
Heart, Lung, Testes, Thyroid, Skin, Brain, Liver, Bone, Kidney

Animal Models for Mitral Valve Prolapse or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mitral Valve Prolapse:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0AGT, DBH, FBN1
2MP:00053678.4AGTR1, AGT, BMP4, FBN1
3MP:00107718.1SLC6A2, BMP4, DBH, FBN1
4MP:00053798.1FBN1, DBH, TSHR, BMP4
5MP:00053897.9FBN1, TSHR, BMP4, AGT
6MP:00053857.5FBN1, DBH, BMP4, SLC6A2, AGT, AGTR1
7MP:00053867.4FBN1, DBH, TSHR, BMP4, SLC6A2, AGT
8MP:00036317.4FBN1, DBH, TSHR, BMP4, SLC6A2, AGT
9MP:00107687.3FBN1, DBH, TSHR, BMP4, AGT, AGTR1
10MP:00053787.0AGTR1, FBN1, DBH, TSHR, BMP4, SLC6A2
11MP:00053767.0FBN1, DBH, TSHR, BMP4, SLC6A2, AGT

Publications for Mitral Valve Prolapse

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52PubMed
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Articles related to Mitral Valve Prolapse:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
High prevalence of 'mitral valve prolapse syndrome' (MVPS) among older children and adolescents in a contained population. (23684344)
2013
2
Minimally invasive repair of posterior leaflet mitral valve prolapse with the "respect" approach. (24349991)
2013
3
Mitral valve prolapse with left atrial enlargement out of proportion to mitral regurgitation. (22953664)
2012
4
Patient education series. Mitral valve prolapse. (22456215)
2012
5
Diagnosing mitral valve prolapse by improving the predictive power of classifiers. (21819741)
2011
6
My perfectly healthy, athletic brother died at age 38 in his sleep from mitral valve prolapse, which caused sudden cardiac death. My sister and I are worried it could be hereditary. (23019721)
2011
7
Cellular pathology of mitral valve prolapse. (19375355)
2010
8
Clinical and diagnostic significance of measurement of blood activity of endopeptidases and their inhibitors in youths with mitral valve prolapse. (21161039)
2010
9
The flap over mitral valve prolapse. A billowing mitral valve poses trouble mainly when it gets leaky. (20503533)
2009
10
Joint hypermobility in patients with mitral valve prolapse. (19851660)
2009
11
Submitral left ventricular aneurysm presenting as a "strange" mitral valve prolapse. (19303585)
2009
12
A new approach to the treatment of mitral valve prolapse using the MitroFast valvular stenting device. (19218263)
2009
13
Anxiety and mood disorder in young males with mitral valve prolapse. (21197339)
2008
14
Sex differences in morphology and outcomes of mitral valve prolapse. (19047025)
2008
15
Angiotensinogen M235T associated with mitral valve prolapse in young Han Chinese male. (18794618)
2008
16
The use of Magne B6 in order to increase compensatory-adaptive possibilities in youths with primary mitral valve prolapse]. (18756751)
2008
17
The prevalence of mitral valve prolapse in patients undergoing echocardiography for clinical reason. (17292985)
2007
18
Ask the doctor. In a new study I heard about, people who had leaky mitral valves but no symptoms benefited from an operation to fix the valve. Many of the people in the study had mitral valve prolapse, as I do, but my doctor says I don't have a heart murmur. Would surgery help me? (15898152)
2005
19
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
20
Mitral valve prolapse in Cavalier King Charles spaniel: a review and case study. (15785126)
2005
21
Adult women with mitral valve prolapse are more flexible. (16183767)
2005
22
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
23
Joint hypermobility syndrome and mitral valve prolapse in panic disorder. (15380857)
2004
24
Prevention of sudden death in mitral valve prolapse. (15736577)
2004
25
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (12578333)
2003
26
Angiotensin II type 1 receptor gene adenine/cytosine1166 polymorphism is not associated with mitral valve prolapse syndrome in Taiwan Chinese. (11999641)
2002
27
Lack of association between transforming growth factor-beta1 gene polymorphisms and mitral valve prolapse in Taiwan Chinese. (12150293)
2002
28
Heart rate variability and QT dispersion in mitral valve prolapse. (11327046)
2001
29
Pseudoaneurysm of gastroduodenal artery associated with mitral valve prolapse presenting as haemobilia. (11963328)
2001
30
Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs. (10867222)
2000
31
Echocardiography for mitral valve prolapse? (9924490)
1999
32
Epidemiology and inheritance of mitral valve prolapse in Dachshunds. (10499729)
1999
33
Relation between QT dispersion and ventricular arrhythmias in uncomplicated isolated mitral valve prolapse. (10614836)
1999
34
Comment on thyrotropin receptor gene and mitral valve prolapse. (10487723)
1999
35
A potential mechanism for mitral valve prolapse syndrome. (9475583)
1998
36
Mitral valve prolapse syndrome. Nonpharmacologic management. (9444178)
1997
37
Incidence and risk factors for mitral valve prolapse in severe adolescent idiopathic scoliosis. (9326688)
1997
38
Bartter's syndrome, supraventricular tachycardia, mitral valve prolapse, and asthma: a therapeutic challenge. (9030679)
1997
39
Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. (9070556)
1997
40
Mitral valve prolapse. (8648654)
1996
41
Clinical spectrum of skeletal abnormalities and mitral valve prolapse and their clinical implications. (17372429)
1996
42
Chest pain in mitral valve prolapse. (8681999)
1995
43
Exercise-induced mitral regurgitation and antibiotic prophylaxis against infective endocarditis in mitral valve prolapse. (7642881)
1995
44
Combined mitral valve prolapse and atrial septal aneurysm. A cause for embolic events. (7698964)
1994
45
Auscultation for mitral valve prolapse. (7968113)
1994
46
Genetic segregation analysis of familial mitral valve prolapse shows no linkage to fibrillar collagen genes. (2930669)
1989
47
Klinefelter's syndrome and mitral valve prolapse. an echocardiographic study in twenty-two patients. (6743777)
1984
48
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
49
Where are the diseases of yesteryear? DaCosta's syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and the mitral valve prolapse syndrome. (770030)
1976
50
Familial mitral valve prolapse and myotonic dystrophy. (937918)
1976

Variations for Mitral Valve Prolapse

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Expression for genes affiliated with Mitral Valve Prolapse

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Prolapse

Search GEO for disease gene expression data for Mitral Valve Prolapse.

Pathways for genes affiliated with Mitral Valve Prolapse

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50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 55Reactome, 53QIAGEN
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Compounds for genes affiliated with Mitral Valve Prolapse

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1cv 11974459.9AGT, AGTR1
2aliskiren45 1110.9AGTR1, AGT
3cgp42112a459.9AGT, AGTR1
4saralasin459.8AGT, AGTR1
5eprosartan45 29 1111.8AGT, AGTR1
6pd12331945 2910.8AGTR1, AGT
7olmesartan45 29 1111.7AGT, AGTR1
8benazepril45 51 1111.6AGTR1, AGT
9mhpg459.5SLC6A2, DBH
10lisinopril45 51 24 1112.5AGT, AGTR1
11haloperidol45 51 29 3 1113.4AGT, AGTR1, SLC6A2
12amine459.4FBN1, SLC6A2, DBH
13cgmp45 2910.3SLC6A2, AGT, AGTR1
14catecholamine459.3DBH, AGTR1, SLC6A2
15adenine45 24 1111.2TSHR, AGT, AGTR1
16inositol 1,4,5 trisphosphate459.2AGT, AGTR1, TSHR
17tgf beta1459.1FBN1, BMP4, AGTR1
18propylthiouracil45 3 1111.0TSHR, DBH
19cytosine45 2410.0TSHR, AGTR1, SLC6A2, AGT
20vas-a458.9AGT, BMP4, DBH
21epinephrine45 24 1110.9AGTR1, AGT, SLC6A2, DBH
22norepinephrine45 24 1110.9AGT, AGTR1, DBH, SLC6A2
23lysine458.9FBN1, AGTR1, TSHR, DBH
24acetylcholine45 51 29 24 1112.9DBH, AGTR1, AGT, SLC6A2
25superoxide45 249.8DBH, AGT, SLC6A2, AGTR1
26acth458.8AGT, AGTR1, DBH, TSHR
27sucrose45 24 1110.8AGTR1, AGT, TSHR, DBH
28progesterone45 29 61 24 1112.6FBN1, TSHR, BMP4, SLC6A2
29heparin45 29 24 1111.6AGTR1, FBN1, AGT, BMP4
30deoxyribonucleic acid458.6AGTR1, AGT, TSHR, BMP4
31arginine458.5AGTR1, TSHR, FBN1, AGT
32glutamate458.5DBH, FBN1, AGTR1, SLC6A2, TSHR
33alanine458.5DBH, AGTR1, FBN1, SLC6A2, TSHR
34pd 98,059458.5AGT, SLC6A2, BMP4, DBH
35hydrogen45 249.4TSHR, DBH, AGTR1, SLC6A2, AGT
36sodium45 249.4AGTR1, AGT, SLC6A2, TSHR, DBH
37glucose458.3AGTR1, AGT, TSHR, DBH, SLC6A2
38estrogen458.3BMP4, FBN1, SLC6A2, AGTR1, TSHR
39dexamethasone45 51 29 1111.2DBH, BMP4, AGT, AGTR1
40vegf458.2AGTR1, AGT, TSHR, BMP4
41dopamine45 29 24 1111.1DBH, BMP4, SLC6A2, AGT, AGTR1
42adenylate458.0TSHR, BMP4, SLC6A2, AGT, DBH
43lipid458.0AGTR1, AGT, SLC6A2, TSHR, FBN1, DBH
44oligonucleotide458.0AGT, SLC6A2, BMP4, TSHR, DBH
45phosphatidylinositol457.9DBH, TSHR, BMP4, AGT, AGTR1
46forskolin45 51 119.6BMP4, TSHR, SLC6A2, AGT, AGTR1, DBH
47cysteine457.2FBN1, AGTR1, AGT, SLC6A2, TSHR, BMP4
48serine457.2AGTR1, SLC6A2, TSHR, DBH, FBN1, AGT
49tyrosine457.2BMP4, TSHR, AGTR1, FBN1, AGT, DBH
50calcium45 51 24 1110.2AGT, DBH, FBN1, TSHR, BMP4, SLC6A2

GO Terms for genes affiliated with Mitral Valve Prolapse

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16Gene Ontology
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Cellular components related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1AGT, BMP4, DBH, FBN1

Biological processes related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:0338649.8AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:0020349.8AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:0020189.8AGTR1, AGT
4regulation of renal sodium excretionGO:0358139.8AGTR1, AGT
5positive regulation of cholesterol esterificationGO:0108739.8AGT, AGTR1
6low-density lipoprotein particle remodelingGO:0343749.8AGT, AGTR1
7positive regulation of cellular protein metabolic processGO:0322709.8AGTR1, AGT
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
9regulation of vasoconstrictionGO:0192299.7AGTR1, AGT
10positive regulation of reactive oxygen species metabolic processGO:20003799.7AGT, AGTR1
11response to painGO:0482659.7SLC6A2, DBH
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.5AGT, AGTR1
13regulation of cell growthGO:0015589.5AGTR1, AGT
14renal system processGO:0030149.4BMP4, AGT
15blood vessel remodelingGO:0019749.4AGT, DBH
16positive regulation of inflammatory responseGO:0507299.4AGTR1, AGT
17positive regulation of endothelial cell migrationGO:0105959.2AGT, BMP4
18regulation of cell proliferationGO:0421279.2AGTR1, AGT, DBH
19G-protein coupled receptor signaling pathwayGO:0071869.2AGTR1, AGT, TSHR
20extracellular matrix organizationGO:0301988.9FBN1, BMP4, AGT
21branching involved in ureteric bud morphogenesisGO:0016588.8AGT, BMP4
22kidney developmentGO:0018228.7AGTR1, AGT, BMP4, FBN1

Molecular functions related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.4AGTR1, AGT, SLC6A2, BMP4, TSHR, FBN1

Products for genes affiliated with Mitral Valve Prolapse

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  • Antibodies
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Sources for Mitral Valve Prolapse

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet