MCID: MTR005
MIFTS: 59

Mitral Valve Prolapse malady

Genetic diseases, Cardiovascular diseases, Fetal diseases, Rare diseases categories
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Summaries for Mitral Valve Prolapse

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MedlinePlus:33 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards based summary: Mitral Valve Prolapse, also known as barlows syndrome, is related to autonomic dysfunction and mood disorder. An important gene associated with Mitral Valve Prolapse is FBN1 (fibrillin 1), and among its related pathways are Arf6 signaling events and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cv 11974 and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and thyroid, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:65 Mitral valve prolapse (aka primary form of myxomatous degeneration of the mitral valve aka floppy mitral... more...

Description from OMIM:46 157700

Aliases & Classifications for Mitral Valve Prolapse

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Mitral Valve Prolapse, Aliases & Descriptions:

Name: Mitral Valve Prolapse 8 10 44 33
Barlows Syndrome 8 62
 
Mitral Valve Prolapse Syndrome 62
Floppy Mitral Valve 8


Classifications:



External Ids:

Disease Ontology8 DOID:988
NCIt39 C50655
MeSH34 D008945
OMIM46 157700

Related Diseases for Mitral Valve Prolapse

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Diseases in the Mitral Valve Prolapse family:

Familial Mitral Valve Prolapse

Diseases related to Mitral Valve Prolapse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic dysfunction30.6DBH, SLC6A2
2mood disorder30.4SLC6A2, DBH
3pulmonary hypertension30.3AGT, BMP4
4hypertension30.2AGTR1, AGT, DBH
5endocarditis10.8
6aneurysm10.8
7familial mitral valve prolapse10.7
8atrial septal aneurysm10.7
9marfan syndrome10.7
10panic disorder10.7
11neurocirculatory asthenia10.6
12cerebritis10.6
13infective endocarditis10.6
14ischemia10.5
15thromboembolism10.5
16keratoconus10.5
17hypermobility syndrome10.5
18anxiety disorder10.5
19migraine10.5
20myocarditis10.5
21thyroiditis10.5
22hypogonadism mitral valve prolapse mental retardation10.5
23mitral valve prolapse, familial, x-linked10.5
24hypogonadism - mitral valve prolapse - intellectual disability10.5
25oppositional defiant disorder10.4SLC6A2
26systemic lupus erythematosus10.4
27type vi ehlers-danlos syndrome10.4
28type i ehlers-danlos syndrome10.4
29rheumatic fever10.4
30endomyocardial fibrosis10.4
31hypertrophic cardiomyopathy10.4
32stickler syndrome10.4
33brain disease10.4
34esophagitis10.4
35lupus erythematosus10.4
36pneumothorax10.4
37congenital contractural arachnodactyly10.4
38mass syndrome10.4
39mitral valve prolapse, familial, autosomal dominant10.4
40stickler syndrome type 110.4
41spontaneous pneumothorax10.4
42left ventricular outflow tract obstruction10.4
43mental retardation10.4
44primary spontaneous pneumothorax10.4
45dysautonomia10.4
46myotonia10.4
47syncope10.4
48mitral valve prolapse, myxomatous 210.4
49mitral valve prolapse, myxomatous 310.4
50mitral valve prolapse, myxomatous 110.4

Graphical network of the top 20 diseases related to Mitral Valve Prolapse:



Diseases related to mitral valve prolapse

Symptoms for Mitral Valve Prolapse

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Clinical features from OMIM:

157700

Drugs & Therapeutics for Mitral Valve Prolapse

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Drug clinical trials:

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Search NIH Clinical Center for Mitral Valve Prolapse

Genetic Tests for Mitral Valve Prolapse

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Anatomical Context for Mitral Valve Prolapse

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MalaCards organs/tissues related to Mitral Valve Prolapse:

32
Heart, Lung, Thyroid, Testes, Brain, Skin, Bone, Kidney, Liver

Animal Models for Mitral Valve Prolapse or affiliated genes

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MGI Mouse Phenotypes related to Mitral Valve Prolapse:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0AGT, DBH, FBN1
2MP:00053678.4AGTR1, AGT, BMP4, FBN1
3MP:00107718.1SLC6A2, BMP4, DBH, FBN1
4MP:00053798.1FBN1, DBH, TSHR, BMP4
5MP:00053897.9FBN1, TSHR, BMP4, AGT
6MP:00053857.5FBN1, DBH, BMP4, SLC6A2, AGT, AGTR1
7MP:00053867.4FBN1, DBH, TSHR, BMP4, SLC6A2, AGT
8MP:00036317.4FBN1, DBH, TSHR, BMP4, SLC6A2, AGT
9MP:00107687.3FBN1, DBH, TSHR, BMP4, AGT, AGTR1
10MP:00053787.0AGTR1, FBN1, DBH, TSHR, BMP4, SLC6A2
11MP:00053767.0FBN1, DBH, TSHR, BMP4, SLC6A2, AGT

Publications for Mitral Valve Prolapse

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Articles related to Mitral Valve Prolapse:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Electrocardiographic changes in mitral valve prolapse syndrome. (24753827)
2014
2
Comparison of the ventricle muscle proteome between patients with rheumatic heart disease and controls with mitral valve prolapse: HSP 60 may be a specific protein in RHD. (24738046)
2014
3
High prevalence of 'mitral valve prolapse syndrome' (MVPS) among older children and adolescents in a contained population. (23684344)
2013
4
Minimally invasive repair of posterior leaflet mitral valve prolapse with the "respect" approach. (24349991)
2013
5
Mitral valve prolapse with left atrial enlargement out of proportion to mitral regurgitation. (22953664)
2012
6
Patient education series. Mitral valve prolapse. (22456215)
2012
7
Diagnosing mitral valve prolapse by improving the predictive power of classifiers. (21819741)
2011
8
My perfectly healthy, athletic brother died at age 38 in his sleep from mitral valve prolapse, which caused sudden cardiac death. My sister and I are worried it could be hereditary. (23019721)
2011
9
Cellular pathology of mitral valve prolapse. (19375355)
2010
10
Clinical and diagnostic significance of measurement of blood activity of endopeptidases and their inhibitors in youths with mitral valve prolapse. (21161039)
2010
11
The flap over mitral valve prolapse. A billowing mitral valve poses trouble mainly when it gets leaky. (20503533)
2009
12
Joint hypermobility in patients with mitral valve prolapse. (19851660)
2009
13
Submitral left ventricular aneurysm presenting as a "strange" mitral valve prolapse. (19303585)
2009
14
A new approach to the treatment of mitral valve prolapse using the MitroFast valvular stenting device. (19218263)
2009
15
Anxiety and mood disorder in young males with mitral valve prolapse. (21197339)
2008
16
Sex differences in morphology and outcomes of mitral valve prolapse. (19047025)
2008
17
Angiotensinogen M235T associated with mitral valve prolapse in young Han Chinese male. (18794618)
2008
18
The use of Magne B6 in order to increase compensatory-adaptive possibilities in youths with primary mitral valve prolapse]. (18756751)
2008
19
The prevalence of mitral valve prolapse in patients undergoing echocardiography for clinical reason. (17292985)
2007
20
Ask the doctor. In a new study I heard about, people who had leaky mitral valves but no symptoms benefited from an operation to fix the valve. Many of the people in the study had mitral valve prolapse, as I do, but my doctor says I don't have a heart murmur. Would surgery help me? (15898152)
2005
21
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
22
Mitral valve prolapse in Cavalier King Charles spaniel: a review and case study. (15785126)
2005
23
Adult women with mitral valve prolapse are more flexible. (16183767)
2005
24
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
25
Joint hypermobility syndrome and mitral valve prolapse in panic disorder. (15380857)
2004
26
Prevention of sudden death in mitral valve prolapse. (15736577)
2004
27
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (12578333)
2003
28
Angiotensin II type 1 receptor gene adenine/cytosine1166 polymorphism is not associated with mitral valve prolapse syndrome in Taiwan Chinese. (11999641)
2002
29
Mitral valve prolapse: old beliefs yield to new knowledge. (12430974)
2002
30
Lack of association between transforming growth factor-beta1 gene polymorphisms and mitral valve prolapse in Taiwan Chinese. (12150293)
2002
31
Heart rate variability and QT dispersion in mitral valve prolapse. (11327046)
2001
32
Pseudoaneurysm of gastroduodenal artery associated with mitral valve prolapse presenting as haemobilia. (11963328)
2001
33
Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs. (10867222)
2000
34
Echocardiography for mitral valve prolapse? (9924490)
1999
35
Epidemiology and inheritance of mitral valve prolapse in Dachshunds. (10499729)
1999
36
Relation between QT dispersion and ventricular arrhythmias in uncomplicated isolated mitral valve prolapse. (10614836)
1999
37
A potential mechanism for mitral valve prolapse syndrome. (9475583)
1998
38
Mitral valve prolapse syndrome. Nonpharmacologic management. (9444178)
1997
39
Incidence and risk factors for mitral valve prolapse in severe adolescent idiopathic scoliosis. (9326688)
1997
40
Bartter's syndrome, supraventricular tachycardia, mitral valve prolapse, and asthma: a therapeutic challenge. (9030679)
1997
41
Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. (9070556)
1997
42
Mitral valve prolapse. (8648654)
1996
43
Clinical spectrum of skeletal abnormalities and mitral valve prolapse and their clinical implications. (17372429)
1996
44
Chest pain in mitral valve prolapse. (8681999)
1995
45
Exercise-induced mitral regurgitation and antibiotic prophylaxis against infective endocarditis in mitral valve prolapse. (7642881)
1995
46
Combined mitral valve prolapse and atrial septal aneurysm. A cause for embolic events. (7698964)
1994
47
Klinefelter's syndrome and mitral valve prolapse. an echocardiographic study in twenty-two patients. (6743777)
1984
48
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
49
Where are the diseases of yesteryear? DaCosta's syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and the mitral valve prolapse syndrome. (770030)
1976
50
Familial mitral valve prolapse and myotonic dystrophy. (937918)
1976

Variations for Mitral Valve Prolapse

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Expression for genes affiliated with Mitral Valve Prolapse

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Expression patterns in normal tissues for genes affiliated with Mitral Valve Prolapse

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Pathways for genes affiliated with Mitral Valve Prolapse

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Compounds for genes affiliated with Mitral Valve Prolapse

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Compounds related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1cv 11974449.9AGT, AGTR1
2aliskiren44 1110.9AGTR1, AGT
3cgp42112a449.9AGT, AGTR1
4saralasin449.8AGT, AGTR1
5eprosartan44 28 1111.8AGT, AGTR1
6pd12331944 2810.8AGTR1, AGT
7olmesartan44 28 1111.7AGT, AGTR1
8benazepril44 50 1111.6AGTR1, AGT
9mhpg449.5SLC6A2, DBH
10lisinopril44 50 24 1112.5AGT, AGTR1
11haloperidol44 50 28 2 1113.4AGT, AGTR1, SLC6A2
12amine449.4FBN1, SLC6A2, DBH
13cgmp44 2810.3SLC6A2, AGT, AGTR1
14catecholamine449.3DBH, AGTR1, SLC6A2
15adenine44 24 1111.2TSHR, AGT, AGTR1
16inositol 1,4,5 trisphosphate449.2AGT, AGTR1, TSHR
17tgf beta1449.1FBN1, BMP4, AGTR1
18propylthiouracil44 2 1111.0TSHR, DBH
19cytosine44 2410.0TSHR, AGTR1, SLC6A2, AGT
20vas-a448.9AGT, BMP4, DBH
21epinephrine44 24 1110.9AGTR1, AGT, SLC6A2, DBH
22norepinephrine44 24 1110.9AGT, AGTR1, DBH, SLC6A2
23lysine448.9FBN1, AGTR1, TSHR, DBH
24acetylcholine44 50 28 24 1112.9DBH, AGTR1, AGT, SLC6A2
25superoxide44 249.8DBH, AGT, SLC6A2, AGTR1
26acth448.8AGT, AGTR1, DBH, TSHR
27sucrose44 24 1110.8AGTR1, AGT, TSHR, DBH
28progesterone44 28 61 24 1112.6FBN1, TSHR, BMP4, SLC6A2
29heparin44 28 24 1111.6AGTR1, FBN1, AGT, BMP4
30deoxyribonucleic acid448.6AGTR1, AGT, TSHR, BMP4
31arginine448.5AGTR1, TSHR, FBN1, AGT
32glutamate448.5DBH, FBN1, AGTR1, SLC6A2, TSHR
33alanine448.5DBH, AGTR1, FBN1, SLC6A2, TSHR
34pd 98,059448.5AGT, SLC6A2, BMP4, DBH
35hydrogen44 249.4TSHR, DBH, AGTR1, SLC6A2, AGT
36sodium44 249.4AGTR1, AGT, SLC6A2, TSHR, DBH
37glucose448.3AGTR1, AGT, TSHR, DBH, SLC6A2
38estrogen448.3BMP4, FBN1, SLC6A2, AGTR1, TSHR
39dexamethasone44 50 28 1111.2DBH, BMP4, AGT, AGTR1
40vegf448.2AGTR1, AGT, TSHR, BMP4
41dopamine44 28 24 1111.1DBH, BMP4, SLC6A2, AGT, AGTR1
42adenylate448.0TSHR, BMP4, SLC6A2, AGT, DBH
43lipid448.0AGTR1, AGT, SLC6A2, TSHR, FBN1, DBH
44oligonucleotide448.0AGT, SLC6A2, BMP4, TSHR, DBH
45phosphatidylinositol447.9DBH, TSHR, BMP4, AGT, AGTR1
46forskolin44 50 119.6BMP4, TSHR, SLC6A2, AGT, AGTR1, DBH
47cysteine447.2FBN1, AGTR1, AGT, SLC6A2, TSHR, BMP4
48serine447.2AGTR1, SLC6A2, TSHR, DBH, FBN1, AGT
49tyrosine447.2BMP4, TSHR, AGTR1, FBN1, AGT, DBH
50calcium44 50 24 1110.2AGT, DBH, FBN1, TSHR, BMP4, SLC6A2

GO Terms for genes affiliated with Mitral Valve Prolapse

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Cellular components related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1AGT, BMP4, DBH, FBN1

Biological processes related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:0020349.8AGT, AGTR1
2positive regulation of NAD(P)H oxidase activityGO:0338649.8AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:0020189.8AGT, AGTR1
4regulation of renal sodium excretionGO:0358139.8AGTR1, AGT
5positive regulation of cholesterol esterificationGO:0108739.8AGTR1, AGT
6low-density lipoprotein particle remodelingGO:0343749.8AGT, AGTR1
7positive regulation of cellular protein metabolic processGO:0322709.8AGT, AGTR1
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
9regulation of vasoconstrictionGO:0192299.7AGT, AGTR1
10positive regulation of reactive oxygen species metabolic processGO:20003799.7AGTR1, AGT
11response to painGO:0482659.7DBH, SLC6A2
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.5AGT, AGTR1
13regulation of cell growthGO:0015589.5AGTR1, AGT
14renal system processGO:0030149.4BMP4, AGT
15blood vessel remodelingGO:0019749.4AGT, DBH
16positive regulation of inflammatory responseGO:0507299.4AGT, AGTR1
17positive regulation of endothelial cell migrationGO:0105959.2BMP4, AGT
18regulation of cell proliferationGO:0421279.2DBH, AGTR1, AGT
19G-protein coupled receptor signaling pathwayGO:0071869.2TSHR, AGTR1, AGT
20extracellular matrix organizationGO:0301988.9FBN1, BMP4, AGT
21branching involved in ureteric bud morphogenesisGO:0016588.8BMP4, AGT
22kidney developmentGO:0018228.7BMP4, FBN1, AGT, AGTR1

Molecular functions related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.4AGTR1, AGT, SLC6A2, BMP4, TSHR, FBN1

Products for genes affiliated with Mitral Valve Prolapse

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Sources for Mitral Valve Prolapse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet