MCID: MTR005
MIFTS: 54

Mitral Valve Prolapse malady

Summaries for Mitral Valve Prolapse

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards: Mitral Valve Prolapse, also known as mitral valve prolapse syndrome, is related to marfan syndrome and panic disorder. An important gene associated with Mitral Valve Prolapse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Monoamine Transport and Elastic fibre formation. The compounds glutamate and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:64 Mitral valve prolapse (aka primary form of myxomatous degeneration of the mitral valve aka floppy mitral... more...

Description from OMIM:47 157700

Aliases & Classifications for Mitral Valve Prolapse

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 47OMIM, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

mitral valve prolapse 8 10 45 34
mitral valve prolapse syndrome 61
floppy mitral valve 8
barlows syndrome 8


External Ids:

Disease Ontology8 DOID:988
OMIM47 157700
NCIt40 C50655
MeSH35 D008945

Related Diseases for Mitral Valve Prolapse

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Mitral Valve Prolapse family:

familial mitral valve prolapse

Diseases related to Mitral Valve Prolapse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1marfan syndrome31.0COL3A1, FBN1, ELN
2panic disorder30.9SLC6A2
3hypermobility syndrome30.6TNXB, TNXA
4mitral valve insufficiency30.5PDLIM1, FBN1
5aortic valve stenosis30.4PDLIM1, ELN
6aortic aneurysm30.3FBN1
7autonomic dysfunction30.3DBH, SLC6A2
8ehlers-danlos syndrome type iv30.3COL3A1, ELN
9thyroiditis30.3TSHR
10hypercholesterolemia30.3AGT, AGTR1, FBN1
11arthritis30.3FBN1, AGTR1, MMP3, LACTB
12asthma30.3GSR, MMP3
13coronary artery disease,30.3COL3A1, FBN1, AGTR1, AGT, PF4, MMP3
14pulmonary disease, chronic obstructive30.3ELN, GSR, LACTB
15aortic valve prolapse10.7
16familial mitral valve prolapse10.7
17atrial septal aneurysm10.7
18neurocirculatory asthenia10.6
19n syndrome10.6
20anxiety disorder10.5
21mitral valve stenosis10.4
22tricuspid valve prolapse10.4
23hypertrophic cardiomyopathy10.4
24mitral valve prolapse, familial, x-linked10.4
25hypogonadism mitral valve prolapse mental retardation10.4
26mitral valve prolapse, myxomatous 110.4
27hypogonadism - mitral valve prolapse - intellectual deficit10.4
28polyvalvular heart disease syndrome10.4
29rheumatic fever10.4
30type vi ehlers-danlos syndrome10.4
31type i ehlers-danlos syndrome10.4
32systemic lupus erythematosus10.4
33endomyocardial fibrosis10.4
34adult syndrome10.4
35stickler syndrome10.4
36brain disease10.4
37congenital contractural arachnodactyly10.4
38stickler syndrome type 110.4
39young syndrome10.4
40stratton-garcia-young syndrome10.4
41left ventricular noncompaction10.4
42mass syndrome10.4
43mitral valve prolapse, familial, autosomal dominant10.4
44spontaneous pneumothorax10.4
45left ventricular outflow tract obstruction10.4
46mental retardation10.4
47primary spontaneous pneumothorax10.4
48dysautonomia10.4
49myotonia10.4
50syncope10.4

Graphical network of the top 20 diseases related to Mitral Valve Prolapse:



Diseases related to mitral valve prolapse

Clinical Features for Mitral Valve Prolapse

Sources:
47OMIM
See all sources

Clinical features from OMIM:

157700

Drugs & Therapeutics for Mitral Valve Prolapse

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mitral Valve Prolapse

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Prolapse

Search NIH Clinical Center for Mitral Valve Prolapse

Search CenterWatch for Mitral Valve Prolapse

Genetic Tests for Mitral Valve Prolapse

Anatomical Context for Mitral Valve Prolapse

Sources:
33MalaCards
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MalaCards organs/tissues related to Mitral Valve Prolapse:

33
Skin, Liver, Brain, Kidney, Lung, Heart, Skeletal muscle, Thyroid, T cells, B cells

Animal Models for Mitral Valve Prolapse or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Mitral Valve Prolapse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.9FBN1, AGTR1, AGT, DBH, GSR, BMP4
2MP:00053769.1ELN, COL3A1, BMP4, FBN1, AGTR1, AGT

Publications for Mitral Valve Prolapse

Sources:
51PubMed
See all sources

Articles related to Mitral Valve Prolapse:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
High prevalence of 'mitral valve prolapse syndrome' (MVPS) among older children and adolescents in a contained population. (23684344)
2013
2
Characterization of mitral valve prolapse with cardiac computed tomography: comparison to echocardiographic and intraoperative findings. (21604082)
2012
3
My perfectly healthy, athletic brother died at age 38 in his sleep from mitral valve prolapse, which caused sudden cardiac death. My sister and I are worried it could be hereditary. (23019721)
2011
4
Rothia dentocariosa endocarditis with mitral valve prolapse: case report and brief review. (21311946)
2011
5
Mitral valve prolapse is the commonest cause of mitral regurgitation in contemporary China. (21056486)
2011
6
Cellular pathology of mitral valve prolapse. (19375355)
2010
7
Prevalence of mitral valve prolapse and associated valvular regurgitations in healthy teenagers undergoing screening echocardiography. (20664768)
2010
8
Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. (19804471)
2010
9
Electrocardiographic abnormalities in young athletes with mitral valve prolapse. (19455568)
2009
10
Comparison of real time two-dimensional with live/real time three-dimensional transesophageal echocardiography in the evaluation of mitral valve prolapse and chordae rupture. (18986397)
2008
11
Mitral valve prolapse: a deeper look. (19225572)
2008
12
How does the use of polytetrafluoroethylene neochordae for posterior mitral valve prolapse (loop technique) compare with leaflet resection? A prospective randomized trial. (19026803)
2008
13
QT dispersion and diastolic functions in differential diagnosis of primary mitral valve prolapse and rheumatic mitral valve prolapse. (17917767)
2008
14
Three-dimensional echocardiography in patient with mitral valve prolapse. (18709254)
2008
15
Imbalance in the antioxidant defense system as a possible cause of decreased compensatory and adaptive reserves in youths with mitral valve prolapse. (18239773)
2007
16
Mitral valve prolapse: now you see it; now you don't: recalling the discovery, rise and decline of a diagnosis. (17196476)
2007
17
"Adjustable" artificial chordal replacement for repair of mitral valve prolapse. (16564319)
2006
18
Frequency of atrial fibrillation in patients having mitral valve repair or replacement for pure mitral regurgitation secondary to mitral valve prolapse. (16563912)
2006
19
Experimental stenting of the posterior mitral leaflet to correct prolapse in mitral valve insufficiency. (16112933)
2005
20
Mitral valve prolapse syndrome health concerns, symptoms, and treatments. (15870233)
2005
21
Mitral valve prolapse associated with ostium secundum atrial septal defect--a functional disorder. (15139697)
2004
22
Multiplane transesophageal echocardiography performed according to the guidelines of the American Society of Echocardiography in patients with mitral valve prolapse, flail, and endocarditis: diagnostic accuracy in the identification of mitral regurgitant defects by correlation with surgical findings. (12514636)
2003
23
Anomaly of the origin of the left coronary artery in children: presentation as mitral valve prolapse with mitral insufficiency and normal left ventricular function. (12674666)
2003
24
Sudden death in mitral valve prolapse and severe mitral regurgitation. Is chordal rupture an indication to early surgery? (12813402)
2003
25
Mitral valve prolapse: old beliefs yield to new knowledge. (12430974)
2002
26
Mitral valve prolapse: the Merchant of Venice or the Tales of Hoffman? (11741366)
2002
27
Echocardiographic features of extreme mitral valve prolapse vs mitral valve aneurysm. (11981583)
2002
28
Degenerative mitral valve disease with emphasis on mitral valve prolapse. (12369588)
2002
29
Mitral valve prolapse and cardiac arrhythmias. (11984033)
2002
30
Mitral valve prolapse and thromboembolic events. (11344843)
2001
31
Relationship between IFN-gamma production by blood lymphocytes and constitutional personality features of patients with idiopathic mitral valve prolapse. (11550034)
2001
32
Comparison of mitral valve prolapse in dogs and humans. (11199900)
2001
33
Assessment of left ventricular systolic function in patients with idiopathic mitral valve prolapse using dobutamine stress echocardiography. (11061058)
2000
34
Mitral valve prolapse: the merchant of venice or much ado about nothing? (10653667)
2000
35
Mitral valve prolapse in the dog: a model of mitral valve prolapse in man. (10946060)
2000
36
Relation between QT dispersion and ventricular arrhythmias in uncomplicated isolated mitral valve prolapse. (10614836)
1999
37
Comment on thyrotropin receptor gene and mitral valve prolapse. (10487723)
1999
38
Mitral valve prolapse and medical testing. (10445991)
1999
39
Images in cardiovascular medicine. Leaflet-dependent spectrum of regurgitant jet in mitral valve prolapse. (9498545)
1998
40
Signal averaged electrocardiogram after exercise in patients with mitral valve prolapse. (9249612)
1997
41
Cardiovascular reactivity of mitral valve prolapse patients during experimental stress exposure: evidence for a functional nature of cardiovascular symptoms. (8831859)
1996
42
Clinical and echocardiographic features of mitral valve prolapse patients in a local population. (8942249)
1996
43
Is there increased sympathetic activity in patients with mitral valve prolapse? (8945059)
1996
44
Mitral valve prolapse in a case of Marfan syndrome with congenital cardiac disease, chronic obstructive pulmonary disease and schizophrenia. (7567172)
1995
45
Histopathologic studies of innervation of normal and prolapsed human mitral valves. (8581192)
1995
46
Changes in effective regurgitant orifice throughout systole in patients with mitral valve prolapse. A clinical study using the proximal isovelocity surface area method. (7586265)
1995
47
Mitral valve prolapse in patients with paroxysmal supraventricular tachycardia. (7810502)
1995
48
Spectrum of regurgitation jets in mitral valve prolapse. (8605441)
1995
49
Auscultation for mitral valve prolapse. (7968113)
1994
50
Klinefelter's syndrome and mitral valve prolapse. an echocardiographic study in twenty-two patients. (6743777)
1984

Genetic Variations for Mitral Valve Prolapse

Expression for genes affiliated with Mitral Valve Prolapse

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mitral Valve Prolapse

Search GEO for disease gene expression data for Mitral Valve Prolapse.

Pathways for genes affiliated with Mitral Valve Prolapse

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Mitral Valve Prolapse

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1glutamate4510.7SLC6A2, AGTR1, FBN1
2norepinephrine45 11 2412.6DBH, SLC6A2
3vas-a4510.6BMP4, AGT, DBH
4forskolin45 50 1112.6AGTR1, AGT, DBH, TSHR
5deoxyribonucleic acid4510.5TSHR, AGT, AGTR1, BMP4
6cytosine45 2411.5AGTR1, AGT, SLC6A2, TSHR
7amine4510.4ELN, SLC6A2, DBH, FBN1
8adenine45 11 2412.4AGTR1, AGT, MMP3, TSHR, GSR
9heparin45 29 11 2413.4FBN1, AGT, PF4, MMP3, ELN
10chondroitin sulfate45 2411.4FBN1, PF4, MMP3, ELN
11superoxide45 2411.3AGTR1, AGT, DBH, PF4, SLC6A2
12heparan sulfate45 2411.3BMP4, FBN1, PF4, B3GAT3, ELN
13nacl4510.3ELN, TSHR, MMP3, PF4, DBH
14glycosaminoglycan4510.3ELN, MMP3, B3GAT3, PF4
15oxygen45 2411.3FBN1, AGT, DBH, PF4
16gold4510.3TNXA, FBN1, AGTR1, MMP3
17chloramphenicol45 2 1112.3DBH, MMP3, LACTB, TSHR, ELN
18epinephrine45 11 2412.3AGTR1, AGT, DBH, PF4, SLC6A2, GSR
19ascorbic acid45 2411.3BMP4, FBN1, DBH, MMP3, GSR, ELN
20n acetylcysteine4510.3ELN, GSR, MMP3, AGT, AGTR1
21tgf beta14510.3BMP4, FBN1, AGTR1, PF4, MMP3, ELN
22acetylcholine45 50 29 11 2414.3AGTR1, AGT, DBH, PF4, MMP3, SLC6A2
23quinacrine45 1111.3GSR, MMP3, PF4
24dopamine45 29 11 2413.2BMP4, AGTR1, AGT, DBH, PF4, SLC6A2
25nifedipine45 50 29 1113.2AGTR1, AGT, PF4, ELN
26indomethacin45 60 29 1113.2AGT, PF4, MMP3, GSR, ELN
27histamine45 29 2412.2ELN, SLC6A2, MMP3, PF4, DBH
28pge24510.2BMP4, AGT, DBH, PF4, MMP3, GSR
29fibrinogen4510.2TNXA, TNXB, AGTR1, AGT, PF4, ELN
30cv 119744510.2AGT, AGTR1
31adenylate4510.2BMP4, AGT, DBH, PF4, SLC6A2, TSHR
32pd 98,0594510.2BMP4, AGT, DBH, MMP3, SLC6A2
33cgmp45 2911.2AGTR1, AGT, SLC6A2, ELN
34lysine4510.2TNXA, FBN1, AGTR1, DBH, PF4, TSHR
35creatinine4510.1TNXA, AGTR1, AGT, PF4, MMP3, GSR
36estrogen4510.1BMP4, FBN1, AGTR1, MMP3, SLC6A2, TSHR
37sodium45 2411.1TNXA, AGTR1, AGT, DBH, PF4, MMP3
38vegf4510.1BMP4, AGTR1, AGT, PF4, MMP3, TSHR
39h2o24510.1TNXA, AGTR1, AGT, DBH, GSR, ELN
40arginine4510.0TNXA, FBN1, AGTR1, AGT, PF4, TSHR
41serine4510.0FBN1, AGTR1, AGT, DBH, MMP3, SLC6A2
42genistein45 29 60 2 11 2415.0ELN, GSR, MMP3, AGT, AGTR1
43tyrosine459.9BMP4, FBN1, AGTR1, AGT, DBH, PF4
44glucose459.9AGTR1, AGT, DBH, PF4, MMP3, SLC6A2
45lipid459.9AGT, AGTR1, FBN1, TNXA, DBH, PF4
46cysteine459.8AGT, AGTR1, FBN1, BMP4, DBH, PF4
47alanine459.8ELN, TNXA, FBN1, AGTR1, DBH, PF4
48steroid459.8TNXA, TNXB, BMP4, AGT, PF4, SLC6A2
49estradiol45 11 2411.7AGTR1, AGT, PF4, MMP3, TSHR
50calcium45 50 11 2412.7PDLIM1, TNXA, BMP4, FBN1, AGTR1, AGT

GO Terms for genes affiliated with Mitral Valve Prolapse

Sources:
16Gene Ontology
See all sources

Cellular components related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.9FBN1, MMP3, ELN, TNXB, BMP4
2extracellular regionGO:0055769.6COL3A1, BMP4, FBN1, AGT, DBH, PF4
3extracellular spaceGO:0056159.4AGT, MMP3, FBN1, BMP4, TNXB, PF4

Biological processes related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.6AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.5AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.5AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGT
5positive regulation of cholesterol esterificationGO:01087310.5AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.4PF4, AGT, AGTR1
7blood vessel remodelingGO:00197410.4ELN, DBH, AGT
8extracellular fibril organizationGO:04320610.4TNXB, COL3A1
9response to painGO:04826510.3SLC6A2, DBH
10cell-matrix adhesionGO:00716010.3COL3A1, TNXB, AGT
11low-density lipoprotein particle remodelingGO:03437410.3AGT, AGTR1
12kidney developmentGO:00182210.3BMP4, AGTR1, AGT
13positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
14extracellular matrix organizationGO:03019810.2ELN, COL3A1, BMP4, FBN1, AGT, MMP3
15regulation of cell proliferationGO:0421279.9AGTR1, AGT, DBH

Molecular functions related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00520110.2ELN, FBN1, COL3A1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1

Products for genes affiliated with Mitral Valve Prolapse

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mitral Valve Prolapse

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet