MCID: MTR005
MIFTS: 55

Mitral Valve Prolapse malady

Summaries for Mitral Valve Prolapse

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards: Mitral Valve Prolapse, also known as mitral valve prolapse syndrome, is related to panic disorder and marfan syndrome. An important gene associated with Mitral Valve Prolapse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Monoamine Transport and Elastic fibre formation. The compounds glutamate and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and thyroid, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:63 Mitral valve prolapse (aka primary form of myxomatous degeneration of the mitral valve aka floppy mitral... more...

Description from OMIM:46 157700

Aliases & Classifications for Mitral Valve Prolapse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

mitral valve prolapse 8 10 44 33
mitral valve prolapse syndrome 60
floppy mitral valve 8
barlows syndrome 8


External Ids:

Disease Ontology8 DOID:988
OMIM46 157700
NCIt39 C50655
MeSH34 D008945

Related Diseases for Mitral Valve Prolapse

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17GeneCards, 18GeneDecks
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Diseases in the Mitral Valve Prolapse family:

Familial Mitral Valve Prolapse

Diseases related to Mitral Valve Prolapse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.9SLC6A2
2marfan syndrome30.9COL3A1, FBN1, ELN
3ischemia30.7AGT, PF4, MMP3, SLC6A2, GSR
4migraine30.6DBH
5hypermobility syndrome30.6TNXB, TNXA
6mitral valve insufficiency30.6PDLIM1, FBN1
7thyroiditis30.6TSHR
8pneumothorax30.5COL3A1
9aortic valve stenosis30.3PDLIM1, ELN
10aortic aneurysm30.3FBN1
11hypertension30.3AGTR1, AGT, DBH
12ehlers-danlos syndrome type iv30.3COL3A1, ELN
13arthritis30.3FBN1, AGTR1, MMP3, LACTB
14asthma30.3GSR, MMP3
15connective tissue disease30.3COL3A1, TNXB, FBN1, ELN
16ehlers-danlos syndrome30.3COL3A1, TNXA, TNXB, FBN1, ELN
17coronary artery disease30.3COL3A1, FBN1, AGTR1, AGT, PF4, MMP3
18mitral valve disease10.9
19heart valve prolapse10.8
20endocarditis10.7
21aortic valve prolapse10.7
22neurocirculatory asthenia10.6
23cerebritis10.5
24anxiety disorder10.5
25heart valve disease10.5
26infective endocarditis10.5
27familial mitral valve prolapse10.5
28mitral valve stenosis10.4
29tricuspid valve prolapse10.4
30hypertrophic cardiomyopathy10.4
31myocarditis10.4
32mitral valve prolapse, familial, x-linked10.4
33hypogonadism mitral valve prolapse mental retardation10.4
34hypogonadism - mitral valve prolapse - intellectual deficit10.4
35polyvalvular heart disease syndrome10.4
36rheumatic fever10.3
37type vi ehlers-danlos syndrome10.3
38type i ehlers-danlos syndrome10.3
39systemic lupus erythematosus10.3
40endomyocardial fibrosis10.3
41adult syndrome10.3
42stickler syndrome10.3
43brain disease10.3
44esophagitis10.3
45keratoconus10.3
46lupus erythematosus10.3
47rheumatic disease of mitral valve10.3
48congenital contractural arachnodactyly10.3
49stickler syndrome type 110.3
50stratton-garcia-young syndrome10.3

Graphical network of the top 20 diseases related to Mitral Valve Prolapse:



Diseases related to mitral valve prolapse

Clinical Features for Mitral Valve Prolapse

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Sources:
46OMIM
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Clinical features from OMIM:

157700

Drugs & Therapeutics for Mitral Valve Prolapse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mitral Valve Prolapse

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Prolapse

Search NIH Clinical Center for Mitral Valve Prolapse

Search CenterWatch for Mitral Valve Prolapse

Genetic Tests for Mitral Valve Prolapse

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Anatomical Context for Mitral Valve Prolapse

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32MalaCards
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MalaCards organs/tissues related to Mitral Valve Prolapse:

32
Heart, Lung, Thyroid, Testes, Brain, Skin, Bone, Kidney, Liver

Animal Models for Mitral Valve Prolapse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mitral Valve Prolapse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.9BMP4, FBN1, AGTR1, AGT, DBH, GSR
2MP:00053769.1COL3A1, BMP4, FBN1, AGTR1, AGT, DBH

Publications for Mitral Valve Prolapse

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50PubMed
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Articles related to Mitral Valve Prolapse:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Repair of posterior mitral valve prolapse with a novel leaflet plication clip in an animal model. (24210830)
2014
2
Characterization of mitral valve prolapse with cardiac computed tomography: comparison to echocardiographic and intraoperative findings. (21604082)
2012
3
Mitral valve prolapse is the commonest cause of mitral regurgitation in contemporary China. (21056486)
2011
4
Surgical treatment of anterior mitral valve prolapse using artificial chordae loop. (21163143)
2010
5
Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. (19804471)
2010
6
Submitral left ventricular aneurysm presenting as a "strange" mitral valve prolapse. (19303585)
2009
7
Relationship of heart rate turbulence, heart rate variability and the number of ventricular premature beats in patients with mitral valve prolapse and non-significant regurgitation. (18603315)
2009
8
Electrocardiographic abnormalities in young athletes with mitral valve prolapse. (19455568)
2009
9
Mitral valve prolapse: a deeper look. (19225572)
2008
10
How does the use of polytetrafluoroethylene neochordae for posterior mitral valve prolapse (loop technique) compare with leaflet resection? A prospective randomized trial. (19026803)
2008
11
Three-dimensional echocardiography in patient with mitral valve prolapse. (18709254)
2008
12
Imbalance in the antioxidant defense system as a possible cause of decreased compensatory and adaptive reserves in youths with mitral valve prolapse. (18239773)
2007
13
Mitral valve prolapse: now you see it; now you don't: recalling the discovery, rise and decline of a diagnosis. (17196476)
2007
14
"Adjustable" artificial chordal replacement for repair of mitral valve prolapse. (16564319)
2006
15
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
16
Experimental stenting of the posterior mitral leaflet to correct prolapse in mitral valve insufficiency. (16112933)
2005
17
Mitral valve prolapse syndrome health concerns, symptoms, and treatments. (15870233)
2005
18
Localization and quantification of mitral valve prolapse using three-dimensional echocardiography. (15556817)
2004
19
Mitral valve prolapse associated with ostium secundum atrial septal defect--a functional disorder. (15139697)
2004
20
Anomalous origin of the left coronary artery from the pulmonary artery accompanied by mitral valve prolapse and regurgitation: Surgical implication of dobutamine stress echocardiography. (14712191)
2004
21
Cerebral ischemic events after diagnosis of mitral valve prolapse: a community-based study of incidence and predictive factors. (12738894)
2003
22
Multiplane transesophageal echocardiography performed according to the guidelines of the American Society of Echocardiography in patients with mitral valve prolapse, flail, and endocarditis: diagnostic accuracy in the identification of mitral regurgitant defects by correlation with surgical findings. (12514636)
2003
23
Anomaly of the origin of the left coronary artery in children: presentation as mitral valve prolapse with mitral insufficiency and normal left ventricular function. (12674666)
2003
24
Sudden death in mitral valve prolapse and severe mitral regurgitation. Is chordal rupture an indication to early surgery? (12813402)
2003
25
Degenerative mitral valve disease with emphasis on mitral valve prolapse. (12369588)
2002
26
Mitral valve prolapse and cardiac arrhythmias. (11984033)
2002
27
Relationship between IFN-gamma production by blood lymphocytes and constitutional personality features of patients with idiopathic mitral valve prolapse. (11550034)
2001
28
Comparison of mitral valve prolapse in dogs and humans. (11199900)
2001
29
Angiotensin II type 1 receptor gene polymorphism and mitral valve prolapse syndrome. (10618569)
2000
30
Assessment of left ventricular systolic function in patients with idiopathic mitral valve prolapse using dobutamine stress echocardiography. (11061058)
2000
31
Mitral valve prolapse: the merchant of venice or much ado about nothing? (10653667)
2000
32
Mitral valve prolapse in the dog: a model of mitral valve prolapse in man. (10946060)
2000
33
Mitral valve prolapse and medical testing. (10445991)
1999
34
A family study of anterior mitral leaflet thickness and mitral valve prolapse. (9761102)
1998
35
Bartter's syndrome, supraventricular tachycardia, mitral valve prolapse, and asthma: a therapeutic challenge. (9030679)
1997
36
Signal averaged electrocardiogram after exercise in patients with mitral valve prolapse. (9249612)
1997
37
Clinical spectrum of skeletal abnormalities and mitral valve prolapse and their clinical implications. (17372429)
1996
38
Cardiovascular reactivity of mitral valve prolapse patients during experimental stress exposure: evidence for a functional nature of cardiovascular symptoms. (8831859)
1996
39
Clinical and echocardiographic features of mitral valve prolapse patients in a local population. (8942249)
1996
40
Is there increased sympathetic activity in patients with mitral valve prolapse? (8945059)
1996
41
Recent developments in the diagnosis and management of mitral valve prolapse. (7787275)
1995
42
Mitral valve prolapse in a case of Marfan syndrome with congenital cardiac disease, chronic obstructive pulmonary disease and schizophrenia. (7567172)
1995
43
Renin-aldosterone regulation during upright posture in young men with mitral valve prolapse syndrome. (7655681)
1995
44
Changes in effective regurgitant orifice throughout systole in patients with mitral valve prolapse. A clinical study using the proximal isovelocity surface area method. (7586265)
1995
45
Mitral valve prolapse in patients with paroxysmal supraventricular tachycardia. (7810502)
1995
46
Spectrum of regurgitation jets in mitral valve prolapse. (8605441)
1995
47
Mitral valve prolapse syndrome, panic disorder and agoraphobia. (2594620)
1989
48
An unusual instance of mitral valve prolapse in endomyocardial fibrosis. (745154)
1978
49
Where are the diseases of yesteryear? DaCosta's syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and the mitral valve prolapse syndrome. (770030)
1976
50
Prolapsed mitral valve associated with the Holt-Oram syndrome. (1116403)
1975

Genetic Variations for Mitral Valve Prolapse

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Expression for genes affiliated with Mitral Valve Prolapse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Prolapse

Search GEO for disease gene expression data for Mitral Valve Prolapse.

Pathways for genes affiliated with Mitral Valve Prolapse

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Mitral Valve Prolapse

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7FBN1, AGTR1, SLC6A2
2norepinephrine44 11 2412.6SLC6A2, DBH
3vas-a4410.6BMP4, AGT, DBH
4forskolin44 49 1112.6AGT, TSHR, DBH, AGTR1
5deoxyribonucleic acid4410.5TSHR, AGT, AGTR1, BMP4
6cytosine44 2411.5SLC6A2, TSHR, AGT, AGTR1
7amine4410.4ELN, DBH, FBN1, SLC6A2
8adenine44 11 2412.4AGT, GSR, TSHR, MMP3, AGTR1
9heparin44 28 11 2413.4ELN, AGT, FBN1, MMP3, PF4
10chondroitin sulfate44 2411.4FBN1, PF4, MMP3, ELN
11superoxide44 2411.3DBH, AGT, AGTR1, PF4, SLC6A2
12heparan sulfate44 2411.3BMP4, ELN, B3GAT3, PF4, FBN1
13nacl4410.3PF4, MMP3, TSHR, ELN, DBH
14glycosaminoglycan4410.3ELN, MMP3, B3GAT3, PF4
15oxygen44 2411.3FBN1, AGT, PF4, DBH
16chloramphenicol44 2 1112.3TSHR, ELN, DBH, MMP3, LACTB
17epinephrine44 11 2412.3DBH, AGTR1, AGT, GSR, SLC6A2, PF4
18ascorbic acid44 2411.3FBN1, DBH, ELN, MMP3, GSR, BMP4
19n acetylcysteine4410.3ELN, GSR, AGTR1, AGT, MMP3
20tgf beta14410.3BMP4, MMP3, ELN, PF4, FBN1, AGTR1
21gold4410.3MMP3, AGTR1, FBN1, TNXA
22acetylcholine44 49 28 11 2414.3PF4, DBH, AGT, AGTR1, SLC6A2, MMP3
23quinacrine44 1111.3GSR, PF4, MMP3
24dopamine44 28 11 2413.2PF4, DBH, AGT, AGTR1, BMP4, SLC6A2
25nifedipine44 49 28 1113.2AGTR1, AGT, ELN, PF4
26indomethacin44 59 28 1113.2AGT, PF4, MMP3, ELN, GSR
27histamine44 28 2412.2SLC6A2, MMP3, PF4, DBH, ELN
28pge24410.2AGT, PF4, MMP3, BMP4, DBH, GSR
29fibrinogen4410.2ELN, PF4, AGT, AGTR1, TNXB, TNXA
30cv 119744410.2AGT, AGTR1
31adenylate4410.2SLC6A2, AGT, DBH, PF4, GSR, TSHR
32pd 98,0594410.2MMP3, SLC6A2, DBH, AGT, BMP4
33cgmp44 2811.2AGTR1, AGT, SLC6A2, ELN
34lysine4410.2TSHR, TNXA, ELN, FBN1, PF4, AGTR1
35creatinine4410.1ELN, AGTR1, AGT, PF4, MMP3, GSR
36estrogen4410.1GSR, SLC6A2, MMP3, TSHR, AGTR1, FBN1
37sodium44 2411.1AGTR1, AGT, DBH, PF4, TSHR, TNXA
38vegf4410.1MMP3, PF4, AGT, AGTR1, BMP4, TSHR
39h2o24410.1GSR, AGT, AGTR1, TNXA, ELN, DBH
40arginine4410.0AGTR1, AGT, PF4, TSHR, GSR, ELN
41serine4410.0ELN, TSHR, DBH, FBN1, AGTR1, AGT
42genistein44 28 59 2 11 2415.0AGTR1, AGT, MMP3, GSR, ELN
43tyrosine449.9AGT, TSHR, BMP4, FBN1, SLC6A2, AGTR1
44glucose449.9DBH, TSHR, SLC6A2, MMP3, PF4, AGT
45lipid449.9GSR, FBN1, AGTR1, MMP3, AGT, TSHR
46cysteine449.8DBH, AGT, FBN1, BMP4, PF4, MMP3
47alanine449.8ELN, TNXA, FBN1, AGTR1, DBH, PF4
48steroid449.8TNXB, BMP4, AGT, PF4, SLC6A2, TNXA
49estradiol44 11 2411.7AGTR1, TSHR, MMP3, PF4, AGT
50calcium44 49 11 2412.7AGTR1, FBN1, BMP4, DBH, PDLIM1, AGT

GO Terms for genes affiliated with Mitral Valve Prolapse

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16Gene Ontology
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Cellular components related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.9ELN, MMP3, FBN1, BMP4, TNXB
2extracellular regionGO:0055769.6BMP4, FBN1, AGT, DBH, PF4, MMP3
3extracellular spaceGO:0056159.4COL3A1, TNXB, BMP4, FBN1, AGT, PF4

Biological processes related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.6AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.5AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.5AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGT
5positive regulation of cholesterol esterificationGO:01087310.5AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.4PF4, AGT, AGTR1
7blood vessel remodelingGO:00197410.4ELN, DBH, AGT
8extracellular fibril organizationGO:04320610.4TNXB, COL3A1
9response to painGO:04826510.3SLC6A2, DBH
10cell-matrix adhesionGO:00716010.3COL3A1, TNXB, AGT
11low-density lipoprotein particle remodelingGO:03437410.3AGT, AGTR1
12kidney developmentGO:00182210.3BMP4, AGTR1, AGT
13positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
14extracellular matrix organizationGO:03019810.2ELN, COL3A1, BMP4, FBN1, AGT, MMP3
15regulation of cell proliferationGO:0421279.9AGTR1, AGT, DBH

Molecular functions related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00520110.2ELN, FBN1, COL3A1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1

Products for genes affiliated with Mitral Valve Prolapse

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Sources for Mitral Valve Prolapse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet