MCID: MTR005
MIFTS: 55

Mitral Valve Prolapse malady

Summaries for Mitral Valve Prolapse

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Mitral valve prolapse (mvp) occurs when one of your heart's valves doesn't work properly. the flaps of the valve are "floppy" and don't close tightly. most people who have the condition are born with it. it also tends to run in families. most of the time, mvp doesn't cause any problems. rarely, blood can leak the wrong way through the floppy valve. this can cause palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast) shortness of breath cough fatigue, dizziness, or anxiety migraine headaches chest discomfort most people who have mitral valve prolapse (mvp) don't need treatment because they don't have symptoms and complications. if you need treatment for mvp, medicines can help relieve symptoms or prevent complications. very few people will need surgery to repair or replace the mitral valve. mvp puts you at risk for infective endocarditis, a kind of heart infection. to prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. now, only people at high risk of endocarditis need the antibiotics. nih: national heart, lung, and blood institute

MalaCards: Mitral Valve Prolapse, also known as mitral valve prolapse syndrome, is related to panic disorder and marfan syndrome. An important gene associated with Mitral Valve Prolapse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Monoamine Transport and Elastic fibre formation. The compounds glutamate and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and thyroid, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:63 Mitral valve prolapse (aka primary form of myxomatous degeneration of the mitral valve aka floppy mitral... more...

Description from OMIM:46 157700

Aliases & Classifications for Mitral Valve Prolapse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

mitral valve prolapse 8 10 44 33
mitral valve prolapse syndrome 60
floppy mitral valve 8
barlows syndrome 8


External Ids:

Disease Ontology8 DOID:988
OMIM46 157700
NCIt39 C50655
MeSH34 D008945

Related Diseases for Mitral Valve Prolapse

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17GeneCards, 18GeneDecks
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Diseases in the Mitral Valve Prolapse family:

Familial Mitral Valve Prolapse

Diseases related to Mitral Valve Prolapse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.9SLC6A2
2marfan syndrome30.9COL3A1, FBN1, ELN
3ischemia30.7AGT, PF4, MMP3, SLC6A2, GSR
4migraine30.6DBH
5hypermobility syndrome30.6TNXB, TNXA
6mitral valve insufficiency30.6PDLIM1, FBN1
7thyroiditis30.6TSHR
8pneumothorax30.5COL3A1
9aortic valve stenosis30.3PDLIM1, ELN
10aortic aneurysm30.3FBN1
11hypertension30.3AGTR1, AGT, DBH
12ehlers-danlos syndrome type iv30.3COL3A1, ELN
13arthritis30.3FBN1, AGTR1, MMP3, LACTB
14asthma30.3GSR, MMP3
15connective tissue disease30.3COL3A1, TNXB, FBN1, ELN
16ehlers-danlos syndrome30.3COL3A1, TNXA, TNXB, FBN1, ELN
17coronary artery disease30.3COL3A1, FBN1, AGTR1, AGT, PF4, MMP3
18mitral valve disease10.9
19heart valve prolapse10.8
20endocarditis10.7
21aortic valve prolapse10.7
22neurocirculatory asthenia10.6
23cerebritis10.5
24anxiety disorder10.5
25heart valve disease10.5
26infective endocarditis10.5
27familial mitral valve prolapse10.5
28mitral valve stenosis10.4
29tricuspid valve prolapse10.4
30hypertrophic cardiomyopathy10.4
31myocarditis10.4
32mitral valve prolapse, familial, x-linked10.4
33hypogonadism mitral valve prolapse mental retardation10.4
34hypogonadism - mitral valve prolapse - intellectual deficit10.4
35polyvalvular heart disease syndrome10.4
36rheumatic fever10.3
37type vi ehlers-danlos syndrome10.3
38type i ehlers-danlos syndrome10.3
39systemic lupus erythematosus10.3
40endomyocardial fibrosis10.3
41adult syndrome10.3
42stickler syndrome10.3
43brain disease10.3
44esophagitis10.3
45keratoconus10.3
46lupus erythematosus10.3
47rheumatic disease of mitral valve10.3
48congenital contractural arachnodactyly10.3
49stickler syndrome type 110.3
50stratton-garcia-young syndrome10.3

Graphical network of the top 20 diseases related to Mitral Valve Prolapse:



Diseases related to mitral valve prolapse

Clinical Features for Mitral Valve Prolapse

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46OMIM
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Clinical features from OMIM:

157700

Drugs & Therapeutics for Mitral Valve Prolapse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mitral Valve Prolapse

Drug clinical trials:

Search ClinicalTrials for Mitral Valve Prolapse

Search NIH Clinical Center for Mitral Valve Prolapse

Search CenterWatch for Mitral Valve Prolapse

Genetic Tests for Mitral Valve Prolapse

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Anatomical Context for Mitral Valve Prolapse

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32MalaCards
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MalaCards organs/tissues related to Mitral Valve Prolapse:

32
Heart, Lung, Thyroid, Testes, Brain, Skin, Bone, Kidney, Liver

Animal Models for Mitral Valve Prolapse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mitral Valve Prolapse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.9FBN1, AGTR1, AGT, DBH, GSR, BMP4
2MP:00053769.1ELN, COL3A1, BMP4, FBN1, AGTR1, AGT

Publications for Mitral Valve Prolapse

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50PubMed
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Articles related to Mitral Valve Prolapse:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Mean platelet volume may be elevated in mitral valve prolapse and associated with the severity of prolapse. (23064218)
2013
2
Pre-operative CT coronary angiography in patients with mitral valve prolapse referred for surgical repair: comparison of accuracy, radiation dose and cost versus invasive coronary angiography. (22959395)
2013
3
A near 100% repair rate for mitral valve prolapse is achievable in a reference center: implications for future guidelines. (22698565)
2012
4
Classic mitral valve prolapse causes enlargement in left ventricle even in the absence of significant mitral regurgitation. (22044562)
2012
5
Classic and non-classic forms of mitral valve prolapse. (22214735)
2012
6
Successful surgical repair of mitral valve prolapse endocarditis: a case report and review of the current literature. (21478131)
2011
7
Clinical and diagnostic significance of measurement of blood activity of endopeptidases and their inhibitors in youths with mitral valve prolapse. (21161039)
2010
8
Postoperative echocardiographic followup for patients with mitral valve prolapse is essential after mitral valve repair. (20060607)
2010
9
Current concepts in mitral valve prolapse--diagnosis and management. (20702064)
2010
10
Mitral-valve repair for mitral-valve prolapse. (19955526)
2009
11
Echocardiographic assessment of 537 dogs with mitral valve prolapse and leaflet involvement. (19697608)
2009
12
Anxiety and mood disorder in young males with mitral valve prolapse. (21197339)
2008
13
Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients. (17765638)
2007
14
Prevalence of mitral valve prolapse in primary spontaneous pneumothorax. (17064962)
2006
15
Abnormalities of ventricular repolarization in mitral valve prolapse. (16029380)
2005
16
Silent cerebral infarct in patients with mitral valve prolapse. (16223699)
2005
17
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
18
Joint hypermobility syndrome and mitral valve prolapse in panic disorder. (15380857)
2004
19
A report case of sudden cardiac death in a young adult male from northeastern part of Thailand with mitral valve prolapse. (15217187)
2004
20
Lack of association between perlecan gene intron 6 BamHI polymorphism and risk of mitral valve prolapse in Taiwan Chinese. (14973356)
2004
21
Prevalence of mitral valve prolapse in ethnic groups. (15100753)
2004
22
Ischemic mitral valve prolapse: mechanisms and implications for valve repair. (15541971)
2004
23
Evaluation of mitral valve prolapse using newly developed real-time three-dimensional echocardiographic system with real-time volume rendering. (12602481)
2003
24
Complications of mitral valve prolapse. (12060909)
2002
25
Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study. (12383578)
2002
26
Anaesthesia for caesarean section in a patient with Ehlers-Danlos syndrome and mitral valve prolapse. (15321609)
2001
27
Mitral valve prolapse: a review of the literature. (11419477)
2001
28
Successful surgical ablation of sustained ventricular tachycardia associated with mitral valve prolapse guided by a multielectrode basket catheter. (11449580)
2001
29
Increased platelet aggregation response in Cavalier King Charles Spaniels with mitral valve prolapse. (11380029)
2001
30
Mitral valve prolapse: past misconceptions and future research directions. (11747853)
2001
31
Very long-term survival and durability of mitral valve repair for mitral valve prolapse. (11568020)
2001
32
Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs. (10867222)
2000
33
Radionuclide esophageal transit test to detect esophageal disorders in patients with mitral valve prolapse. (10919158)
2000
34
The treatment of mitral valve prolapse syndrome in a nurse-managed outpatient mitral valve prolapse clinic. (11072285)
2000
35
Severe mitral regurgitation due to mitral valve prolapse: risk factors for development, progression, and need for mitral valve surgery. (10955376)
2000
36
Mitral valve repair vs replacement for mitral valve prolapse with severe mitral regurgitation. (10952353)
2000
37
Perspectives on mitral-valve prolapse. (10387961)
1999
38
Mitral valve prolapse vs flail leaflets. (9519333)
1998
39
Mitral valve prolapse syndrome. Nonpharmacologic management. (9444178)
1997
40
Evaluation of mitral valve prolapse by four-dimensional echocardiography. (9006300)
1997
41
Extensive use of artificial chordae for repairing diffuse mitral valve prolapse. (8784025)
1996
42
Clinical features of subjects with mitral valve prolapse: a study with 24-hour ambulatory blood pressure monitoring. (8894256)
1996
43
Mitral valve prolapse. (8907809)
1995
44
Mitral valve prolapse in 3-year-old healthy Cavalier King Charles Spaniels. An echocardiographic study. (8548691)
1995
45
Combined mitral valve prolapse and atrial septal aneurysm. A cause for embolic events. (7698964)
1994
46
Brachydactyly, mesomelia, mental retardation, aortic dilatation, mitral valve prolapse, and characteristic face. (8484398)
1993
47
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. (8323254)
1993
48
Postinflammatory mitral and aortic valve prolapse: a clinical and pathological study. (3594777)
1987
49
Chaotic atrial tachycardia in the mitral valve prolapse syndrome. (6637775)
1983
50
Left ventricular relaxation, mitral valve prolapse, and intracardiac conduction in myotonia atrophica: assessment by digitized echocardiography and noninvasive His bundle recording. (7090987)
1982

Genetic Variations for Mitral Valve Prolapse

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Expression for genes affiliated with Mitral Valve Prolapse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mitral Valve Prolapse

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Pathways for genes affiliated with Mitral Valve Prolapse

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Mitral Valve Prolapse

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7FBN1, AGTR1, SLC6A2
2norepinephrine44 11 2412.6SLC6A2, DBH
3vas-a4410.6BMP4, AGT, DBH
4forskolin44 49 1112.6AGT, TSHR, DBH, AGTR1
5deoxyribonucleic acid4410.5TSHR, AGT, AGTR1, BMP4
6cytosine44 2411.5SLC6A2, TSHR, AGT, AGTR1
7amine4410.4ELN, DBH, FBN1, SLC6A2
8adenine44 11 2412.4AGT, GSR, TSHR, MMP3, AGTR1
9heparin44 28 11 2413.4ELN, AGT, FBN1, MMP3, PF4
10chondroitin sulfate44 2411.4FBN1, PF4, MMP3, ELN
11superoxide44 2411.3DBH, AGT, AGTR1, PF4, SLC6A2
12heparan sulfate44 2411.3BMP4, ELN, B3GAT3, PF4, FBN1
13nacl4410.3PF4, MMP3, TSHR, ELN, DBH
14glycosaminoglycan4410.3ELN, MMP3, B3GAT3, PF4
15oxygen44 2411.3FBN1, AGT, PF4, DBH
16chloramphenicol44 2 1112.3TSHR, ELN, DBH, MMP3, LACTB
17epinephrine44 11 2412.3DBH, AGTR1, AGT, GSR, SLC6A2, PF4
18ascorbic acid44 2411.3FBN1, DBH, ELN, MMP3, GSR, BMP4
19n acetylcysteine4410.3ELN, GSR, AGTR1, AGT, MMP3
20tgf beta14410.3BMP4, MMP3, ELN, PF4, FBN1, AGTR1
21gold4410.3MMP3, AGTR1, FBN1, TNXA
22acetylcholine44 49 28 11 2414.3PF4, DBH, AGT, AGTR1, SLC6A2, MMP3
23quinacrine44 1111.3GSR, PF4, MMP3
24dopamine44 28 11 2413.2PF4, DBH, AGT, AGTR1, BMP4, SLC6A2
25nifedipine44 49 28 1113.2AGTR1, AGT, ELN, PF4
26indomethacin44 59 28 1113.2AGT, PF4, MMP3, ELN, GSR
27histamine44 28 2412.2SLC6A2, MMP3, PF4, DBH, ELN
28pge24410.2AGT, PF4, MMP3, BMP4, DBH, GSR
29fibrinogen4410.2ELN, PF4, AGT, AGTR1, TNXB, TNXA
30cv 119744410.2AGT, AGTR1
31adenylate4410.2SLC6A2, AGT, DBH, PF4, GSR, TSHR
32pd 98,0594410.2MMP3, SLC6A2, DBH, AGT, BMP4
33cgmp44 2811.2AGTR1, AGT, SLC6A2, ELN
34lysine4410.2TSHR, TNXA, ELN, FBN1, PF4, AGTR1
35creatinine4410.1ELN, AGTR1, AGT, PF4, MMP3, GSR
36estrogen4410.1GSR, SLC6A2, MMP3, TSHR, AGTR1, FBN1
37sodium44 2411.1AGTR1, AGT, DBH, PF4, TSHR, TNXA
38vegf4410.1MMP3, PF4, AGT, AGTR1, BMP4, TSHR
39h2o24410.1GSR, AGT, AGTR1, TNXA, ELN, DBH
40arginine4410.0AGTR1, AGT, PF4, TSHR, GSR, ELN
41serine4410.0ELN, TSHR, DBH, FBN1, AGTR1, AGT
42genistein44 28 59 2 11 2415.0AGTR1, AGT, MMP3, GSR, ELN
43tyrosine449.9AGT, TSHR, BMP4, FBN1, SLC6A2, AGTR1
44glucose449.9DBH, TSHR, SLC6A2, MMP3, PF4, AGT
45lipid449.9GSR, FBN1, AGTR1, MMP3, AGT, TSHR
46cysteine449.8DBH, AGT, FBN1, BMP4, PF4, MMP3
47alanine449.8ELN, TNXA, FBN1, AGTR1, DBH, PF4
48steroid449.8TNXB, BMP4, AGT, PF4, SLC6A2, TNXA
49estradiol44 11 2411.7AGTR1, TSHR, MMP3, PF4, AGT
50calcium44 49 11 2412.7AGTR1, FBN1, BMP4, DBH, PDLIM1, AGT

GO Terms for genes affiliated with Mitral Valve Prolapse

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16Gene Ontology
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Cellular components related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.9ELN, MMP3, FBN1, BMP4, TNXB
2extracellular regionGO:0055769.6BMP4, FBN1, AGT, DBH, PF4, MMP3
3extracellular spaceGO:0056159.4COL3A1, TNXB, BMP4, FBN1, AGT, PF4

Biological processes related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.6AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.5AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.5AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGT
5positive regulation of cholesterol esterificationGO:01087310.5AGT, AGTR1
6positive regulation of macrophage derived foam cell differentiationGO:01074410.4PF4, AGT, AGTR1
7blood vessel remodelingGO:00197410.4ELN, DBH, AGT
8extracellular fibril organizationGO:04320610.4TNXB, COL3A1
9response to painGO:04826510.3SLC6A2, DBH
10cell-matrix adhesionGO:00716010.3COL3A1, TNXB, AGT
11low-density lipoprotein particle remodelingGO:03437410.3AGT, AGTR1
12kidney developmentGO:00182210.3BMP4, AGTR1, AGT
13positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
14extracellular matrix organizationGO:03019810.2ELN, COL3A1, BMP4, FBN1, AGT, MMP3
15regulation of cell proliferationGO:0421279.9AGTR1, AGT, DBH

Molecular functions related to Mitral Valve Prolapse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00520110.2ELN, FBN1, COL3A1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1

Products for genes affiliated with Mitral Valve Prolapse

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  • Antibodies
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Sources for Mitral Valve Prolapse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet