MCID: MXD014
MIFTS: 29

Mixed Ductal-Endocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Mixed Ductal-Endocrine Carcinoma

MalaCards integrated aliases for Mixed Ductal-Endocrine Carcinoma:

Name: Mixed Ductal-Endocrine Carcinoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7716
NCIt 46 C6879
SNOMED-CT 64 396892009 999000
UMLS 69 C1301048

Summaries for Mixed Ductal-Endocrine Carcinoma

MalaCards based summary : Mixed Ductal-Endocrine Carcinoma is related to zollinger-ellison syndrome and gastrinoma. An important gene associated with Mixed Ductal-Endocrine Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Adhesion and Cell adhesion_Cell-matrix glycoconjugates. Affiliated tissues include pancreas and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mixed Ductal-Endocrine Carcinoma

Diseases related to Mixed Ductal-Endocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 zollinger-ellison syndrome 30.5 CHGA GAST SST
2 gastrinoma 30.5 CHGA GAST SST
3 autoimmune atrophic gastritis 10.7 CHGA GAST
4 ureter small cell carcinoma 10.6 CHGA SYP
5 gastric gastrinoma 10.6 ENO2 GAST
6 acinar cell cystadenocarcinoma 10.6 CHGA SYP
7 intracranial primitive neuroectodermal tumor 10.6 CHGA ENO2
8 peritoneal serous adenocarcinoma 10.6 CHGA SYP
9 cellular ependymoma 10.6 CHGA SYP
10 primary hepatic neuroendocrine carcinoma 10.6 CHGA SYP
11 gastrointestinal neuroendocrine tumor 10.6 CHGA SYP
12 malignant sertoli cell tumor 10.6 ENO2 SYP
13 sensory organ benign neoplasm 10.5 ENO2 SYP
14 ovarian carcinosarcoma 10.5 ENO2 SYP
15 non-functioning pancreatic endocrine tumor 10.5 CHGA GAST SYP
16 goblet cell carcinoid 10.5 CHGA ENO2 GAST
17 central nervous system primitive neuroectodermal neoplasm 10.5 ENO2 SYP
18 urinary bladder small cell neuroendocrine carcinoma 10.5 CHGA ENO2 SYP
19 cerebellum cancer 10.5 ENO2 SYP
20 auditory system cancer 10.5 CHGA ENO2 SYP
21 pilomatrix carcinoma 10.5 ENO2 MUC1
22 small cell carcinoma of the bladder 10.5 CHGA ENO2 SYP
23 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA ENO2 SYP
24 subependymal glioma 10.5 ENO2 SYP
25 pylorospasm 10.5 GAST SST
26 olfactory nerve neoplasm 10.5 CHGA ENO2 SYP
27 intracranial cysts 10.5 ENO2 MUC1
28 cauda equina neoplasm 10.5 CHGA ENO2 SYP
29 pancreatic intraductal papillary-mucinous neoplasm 10.5 MUC1 MUC6
30 pineocytoma 10.5 CHGA ENO2 SYP
31 cerebral neuroblastoma 10.4 ENO2 SYP
32 malignant glandular tumor of peripheral nerve sheath 10.4 SST SYP
33 papillary ependymoma 10.4 CHGA ENO2 SYP
34 cranial nerve malignant neoplasm 10.4 CHGA ENO2 SYP
35 central neurocytoma 10.4 CHGA ENO2 SYP
36 type c thymoma 10.4 SST SSTR2
37 tumor of exocrine pancreas 10.4 MUC1 MUC6
38 pancreatic islet cell tumors 10.4 GAST SST
39 granulosa cell tumor of the ovary 10.4 CHGA ENO2 SYP
40 cerebellar liponeurocytoma 10.4 CHGA ENO2 SYP
41 nodular ganglioneuroblastoma 10.4 CHGA ENO2
42 ganglioglioma 10.4 CHGA ENO2 SYP
43 clear cell meningioma 10.4 CHGA MUC1
44 extraosseous chondrosarcoma 10.4 ENO2 SYP
45 gastritis 10.4 CHGA GAST MUC6
46 lung combined type small cell carcinoma 10.4 NCAM1 SYP
47 benign ependymoma 10.4 ENO2 SYP
48 chronic ethmoiditis 10.4 MUC1 MUC6
49 multiple mucosal neuroma 10.4 ENO2 NCAM1
50 ureter, cancer of 10.4 CHGA SYP TERT

Graphical network of the top 20 diseases related to Mixed Ductal-Endocrine Carcinoma:



Diseases related to Mixed Ductal-Endocrine Carcinoma

Symptoms & Phenotypes for Mixed Ductal-Endocrine Carcinoma

GenomeRNAi Phenotypes related to Mixed Ductal-Endocrine Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.66 SSTR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.66 CGB8 CGB3 CGB7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.66 CGB3 CGB7 CGB8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.66 SSTR2 CGB3 CGB7 CGB8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.66 SSTR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.66 SSTR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.66 SSTR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.66 CGB3 CGB7 CGB8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.66 SSTR2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.66 SSTR2 CGB3 CGB7 CGB8

MGI Mouse Phenotypes related to Mixed Ductal-Endocrine Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 CALB2 CHGB CHL1 ENO2 NCAM1 SMAD4

Drugs & Therapeutics for Mixed Ductal-Endocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Mixed Ductal-Endocrine Carcinoma

Genetic Tests for Mixed Ductal-Endocrine Carcinoma

Anatomical Context for Mixed Ductal-Endocrine Carcinoma

MalaCards organs/tissues related to Mixed Ductal-Endocrine Carcinoma:

38
Pancreas, Liver

Publications for Mixed Ductal-Endocrine Carcinoma

Articles related to Mixed Ductal-Endocrine Carcinoma:

# Title Authors Year
1
Mixed ductal-endocrine carcinoma of pancreas. ( 22696627 )
2011
2
A case of mixed ductal-endocrine carcinoma of the pancreas. ( 21424939 )
2011
3
Mixed ductal-endocrine carcinoma of the pancreas occurring as a double cancer: report of a case. ( 22026308 )
2011
4
Mixed ductal-endocrine carcinoma of the pancreas metastatic to the liver. ( 21311316 )
2011
5
Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. ( 18453301 )
2008
6
Mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression. ( 18161862 )
2008
7
Minute mixed ductal-endocrine carcinoma of the pancreas with predominant intraductal growth. ( 12685552 )
2002
8
Mixed ductal-endocrine carcinoma of the pancreas: a possible pathogenic mechanism for arrhythmogenic right ventricular cardiomyopathy. ( 10656740 )
2000
9
Mixed ductal-endocrine carcinoma of the pancreas presenting as gastrinoma with Zollinger-Ellison syndrome: an autopsy case with a 24-year survival period. ( 10628803 )
1999

Variations for Mixed Ductal-Endocrine Carcinoma

Expression for Mixed Ductal-Endocrine Carcinoma

Search GEO for disease gene expression data for Mixed Ductal-Endocrine Carcinoma.

Pathways for Mixed Ductal-Endocrine Carcinoma

Pathways related to Mixed Ductal-Endocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 CEACAM5 MUC1 NCAM1
2 10.39 CEACAM5 MUC1 NCAM1
3 9.8 GAST MUC6

GO Terms for Mixed Ductal-Endocrine Carcinoma

Cellular components related to Mixed Ductal-Endocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.4 CEACAM5 CGB3 CGB7 CGB8 CHGA CHGB

Biological processes related to Mixed Ductal-Endocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.55 CGB3 CGB7 CGB8 SST SSTR2
2 regulation of receptor activity GO:0010469 9.43 CGB3 CGB7 CGB8 CHGB GAST SST
3 female gamete generation GO:0007292 8.8 CGB3 CGB7 CGB8

Molecular functions related to Mixed Ductal-Endocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 CGB3 CGB7 CHGB GAST SST

Sources for Mixed Ductal-Endocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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