MCID: MXD014
MIFTS: 24

Mixed Ductal-Endocrine Carcinoma malady

Cancer category

Summaries for Mixed Ductal-Endocrine Carcinoma

Sources:
33MalaCards
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MalaCards: Mixed Ductal-Endocrine Carcinoma is related to papillary carcinoma and pancreatic endocrine carcinoma. An important gene associated with Mixed Ductal-Endocrine Carcinoma is SYP (synaptophysin), and among its related pathways is Selected targets of Oct-3/4. The compounds clomiphene citrate and glutaraldehyde have been mentioned in the context of this disorder. Affiliated tissues include liver and pancreas.

Aliases & Classifications for Mixed Ductal-Endocrine Carcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

mixed ductal-endocrine carcinoma 8 61


External Ids:

Disease Ontology8 DOID:7716
SNOMED-CT57 999000, 396892009
NCIt40 C6879

Related Diseases for Mixed Ductal-Endocrine Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mixed Ductal-Endocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.6KRT19, SYP
2pancreatic endocrine carcinoma10.3
3pancreatic ductal carcinoma10.3
4gastrinoma10.3
5zollinger-ellison syndrome10.3
6bile duct carcinoma10.3
7pancreatic endocrine tumors10.3
8sertoli cell tumor10.0SYP
9medulloepithelioma10.0SYP
10leydig cell tumor10.0CGB5
11extragonadal germ cell tumor10.0CGB5
12thymic carcinoma10.0SYP
13ganglioneuroma10.0SYP
14dysgerminoma10.0CGB5
15gynecomastia10.0CGB5
16germinoma10.0CGB5, CGB
17placental site trophoblastic tumor10.0CGB, CGB5
18large cell carcinoma10.0CGB5, SYP
19endodermal sinus tumor10.0CGB5, CGB
20gestational trophoblastic tumor10.0CGB5, CGB
21hyperthyroidism10.0CGB5, CGB
22prostate cancer10.0TERT, CGB
23pituitary adenoma10.0SYP, CGB7
24deficiency anemia10.0CGB, CGB5
25hyperprolactinemia10.0CGB5, CGB
26oxyphilic adenoma10.0SYP, KRT19
27neuroendocrine carcinoma10.0SYP, KRT19
28ectopic pregnancy10.0CGB, CGB7, CGB5
29pregnancy loss10.0CGB7, CGB5, CGB
30gestational trophoblastic neoplasm10.0CGB5, CGB7, CGB
31neural tube defects10.0CGB7, CGB5, CGB
32embryonal cancer10.0CGB7, CGB5, CGB
33thyroid cancer10.0TERT, KRT19
34adenoameloblastoma10.0TERT, KRT19
35down syndrome10.0CGB, CGB7, CGB5
36seminoma10.0CGB, CGB7, CGB5
37factor v leiden thrombophilia10.0CGB7, CGB5, CGB
38pre-eclampsia10.0CGB, CGB7, CGB5
39sarcoma10.0CGB5, CGB, TERT
40lung cancer10.0KRT19, SYP
41cryptococcosis10.0CGB8, CGB7, CGB5, CGB
42choriocarcinoma10.0CGB5, CGB7, CGB
43pancreatic cancer10.0TERT, KRT19, SYP
44non-small cell lung carcinoma10.0SYP, KRT19, TERT
45lung benign neoplasm10.0KRT19, SYP, TERT
46neuroendocrine tumor10.0SYP, KRT19
47bladder carcinoma10.0KRT19, CGB, TERT
48brain cancer10.0CGB5, SYP, CGB, TERT
49cholangiocarcinoma10.0CGB, KRT19, TERT
50teratoma10.0CGB5, CGB7, CGB, TERT

Graphical network of the top 20 diseases related to Mixed Ductal-Endocrine Carcinoma:



Diseases related to mixed ductal-endocrine carcinoma

Clinical Features for Mixed Ductal-Endocrine Carcinoma

Drugs & Therapeutics for Mixed Ductal-Endocrine Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mixed Ductal-Endocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Mixed Ductal-Endocrine Carcinoma

Search NIH Clinical Center for Mixed Ductal-Endocrine Carcinoma

Search CenterWatch for Mixed Ductal-Endocrine Carcinoma

Genetic Tests for Mixed Ductal-Endocrine Carcinoma

Anatomical Context for Mixed Ductal-Endocrine Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Mixed Ductal-Endocrine Carcinoma:

33
Liver, Pancreas

Animal Models for Mixed Ductal-Endocrine Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mixed Ductal-Endocrine Carcinoma

Sources:
51PubMed
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Articles related to Mixed Ductal-Endocrine Carcinoma:

idTitleAuthorsYear
1
Mixed ductal-endocrine carcinoma of pancreas. (22696627)
2011
2
Mixed ductal-endocrine carcinoma of the pancreas occurring as a double cancer: report of a case. (22026308)
2011
3
Mixed ductal-endocrine carcinoma of the pancreas metastatic to the liver. (21311316)
2011
4
A case of mixed ductal-endocrine carcinoma of the pancreas. (21424939)
2011
5
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. (20182344)
2010
6
Mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression. (18161862)
2008
7
Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. (18453301)
2008
8
Minute mixed ductal-endocrine carcinoma of the pancreas with predominant intraductal growth. (12685552)
2002
9
Mixed ductal-endocrine carcinoma of the pancreas: a possible pathogenic mechanism for arrhythmogenic right ventricular cardiomyopathy. (10656740)
2000
10
Mixed ductal-endocrine carcinoma of the pancreas presenting as gastrinoma with Zollinger-Ellison syndrome: an autopsy case with a 24-year survival period. (10628803)
1999

Genetic Variations for Mixed Ductal-Endocrine Carcinoma

Expression for genes affiliated with Mixed Ductal-Endocrine Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Ductal-Endocrine Carcinoma

Search GEO for disease gene expression data for Mixed Ductal-Endocrine Carcinoma.

Pathways for genes affiliated with Mixed Ductal-Endocrine Carcinoma

Sources:
12EMD Millipore
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Pathways related to Mixed Ductal-Endocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CGB, CGB7

Compounds for genes affiliated with Mixed Ductal-Endocrine Carcinoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Mixed Ductal-Endocrine Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1clomiphene citrate459.8CGB5, CGB
2glutaraldehyde459.8SYP, CGB5
3ifosfamide45 1110.7CGB, CGB5
4smcc459.6KRT19, SYP
5leucovorin45 50 1111.5CGB, CGB5
6b 723459.5SYP, KRT19
7oestriol459.3CGB5, CGB7, CGB
8hematoxylin459.3KRT19, SYP
9ctp459.3CGB, CGB7, CGB5
10bleomycin45 1110.2CGB5, CGB7, CGB
11methotrexate45 50 1111.2CGB5, CGB7, CGB
12gnrh459.2CGB, CGB7, CGB5
1317beta-hydroxysteroid459.0KRT19, CGB5
14ribonucleic acid458.9TERT, KRT19, CGB5
15paclitaxel45 50 1110.9TERT, KRT19, CGB5
16genistein45 29 60 2 11 2413.8CGB5, SYP, TERT
17glycogen45 249.8CGB5, SYP, KRT19
18cysteine458.8CGB7, CGB, SYP, TERT
19creatinine458.6KRT19, SYP, CGB, CGB5
20paraffin458.6TERT, KRT19, SYP, CGB5
21etoposide45 50 60 1111.5CGB5, CGB7, CGB, SYP, TERT
22lactate458.4CGB5, CGB7, CGB, KRT19
23vegf458.2CGB5, CGB, SYP, KRT19, TERT
24estradiol45 11 2410.1CGB5, CGB7, CGB, SYP, KRT19
25progesterone45 60 29 11 2412.1CGB5, CGB7, CGB, SYP, KRT19
26retinoic acid45 249.0CGB5, CGB7, SYP, KRT19, TERT
27cisplatin45 50 60 1110.7TERT, KRT19, SYP, CGB, CGB7, CGB5
28testosterone45 60 11 2410.6CGB5, CGB7, CGB, SYP, KRT19, TERT

GO Terms for genes affiliated with Mixed Ductal-Endocrine Carcinoma

Products for genes affiliated with Mixed Ductal-Endocrine Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mixed Ductal-Endocrine Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet